Receptor
PDB id Resolution Class Description Source Keywords
5JQ1 1.83 Å NON-ENZYME: SIGNAL_HORMONE EFFICIENT TARGETING OF THE ASIALOGLYCOPROTEIN RECEPTOR BY PO DISPLAY OF A COMPACT GALACTOSAMINE MIMIC HOMO SAPIENS ASIALOGLYCOPROTEIN RECEPTOR CARBOHYDRATES LIVER TARGETINGBINDING PROTEIN
Ref.: EFFICIENT LIVER TARGETING BY POLYVALENT DISPLAY OF LIGAND FOR THE ASIALOGLYCOPROTEIN RECEPTOR. J. AM. CHEM. SOC. V. 139 3528 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CA A:1003;
B:1001;
A:1001;
A:1002;
B:1002;
B:1004;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
none;
none;
submit data
40.078 Ca [Ca+2...
ZPF B:1003;
A:1004;
Valid;
Valid;
none;
none;
submit data
233.218 C9 H15 N O6 CC(=O...
CL A:1005;
Invalid;
none;
submit data
35.453 Cl [Cl-]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5JQ1 1.83 Å NON-ENZYME: SIGNAL_HORMONE EFFICIENT TARGETING OF THE ASIALOGLYCOPROTEIN RECEPTOR BY PO DISPLAY OF A COMPACT GALACTOSAMINE MIMIC HOMO SAPIENS ASIALOGLYCOPROTEIN RECEPTOR CARBOHYDRATES LIVER TARGETINGBINDING PROTEIN
Ref.: EFFICIENT LIVER TARGETING BY POLYVALENT DISPLAY OF LIGAND FOR THE ASIALOGLYCOPROTEIN RECEPTOR. J. AM. CHEM. SOC. V. 139 3528 2017
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 5JPV - LBT C12 H22 O11 C([C@@H]1[....
2 5JQ1 - ZPF C9 H15 N O6 CC(=O)N[C@....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 5JPV - LBT C12 H22 O11 C([C@@H]1[....
2 5JQ1 - ZPF C9 H15 N O6 CC(=O)N[C@....
50% Homology Family (25)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 3P5I - G6S NAG n/a n/a
2 3P5H - BGC BGC n/a n/a
3 4N37 - MMA C7 H14 O6 CO[C@@H]1[....
4 4N34 - 2F8 C9 H17 N O6 CC(=O)N[C@....
5 3P5E - MAN C6 H12 O6 C([C@@H]1[....
6 3P5D - MAN C6 H12 O6 C([C@@H]1[....
7 5G6U ic50 = 0.22 uM YJM C6 H13 N O11 S2 C([C@@H]1[....
8 5VYB - MAN MAN MAN BMA MAN MAN MAN n/a n/a
9 1SL5 - GAL NAG GAL FUC n/a n/a
10 2IT5 - MAN MAN MAN n/a n/a
11 1K9J - NAG MAN MAN MAN NAG n/a n/a
12 1SL4 - MAN MAN MAN MAN n/a n/a
13 2IT6 - MAN MAN n/a n/a
14 1K9I - NAG MAN MAN MAN NAG n/a n/a
15 3VYK Kd = 0.00003 M MMA MAN NAG MAN NAG NAG n/a n/a
16 4KZV - TRE C12 H22 O11 C([C@@H]1[....
17 4ZRV - 4RS C16 H28 O12 CCCC(=O)OC....
18 5KTH - TRE 6X7 6X7 n/a n/a
19 5KTI - TRE 6X6 n/a n/a
20 2OX9 - GAL NAG FUC n/a n/a
21 4ZES Ki = 9.4 mM MMA C7 H14 O6 CO[C@@H]1[....
22 3WH2 - FLC C6 H5 O7 C(C(=O)[O-....
23 5JPV - LBT C12 H22 O11 C([C@@H]1[....
24 5JQ1 - ZPF C9 H15 N O6 CC(=O)N[C@....
25 1SL6 - GAL NDG FUC n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ZPF; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 ZPF 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5JQ1; Ligand: ZPF; Similar sites found with APoc: 1
This union binding pocket(no: 1) in the query (biounit: 5jq1.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
1 4WQQ MAN 45.3901
Pocket No.: 2; Query (leader) PDB : 5JQ1; Ligand: ZPF; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5jq1.bio1) has 12 residues
No: Leader PDB Ligand Sequence Similarity
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