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Receptor
PDB id Resolution Class Description Source Keywords
5LVP 2.5 Å EC: 2.7.11.1 HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH AN HM-PEPTIDE BOUND PIF-POCKET HOMO SAPIENS PROTEIN KINASE ALLOSTERIC REGULATION SMALL COMPOUNDS PIF-TRANSFERASE
Ref.: BIDIRECTIONAL ALLOSTERIC COMMUNICATION BETWEEN THE ATP-BINDING SITE AND THE REGULATORY PIF POCKET IN P PROTEIN KINASE. CELL CHEM BIOL V. 23 1193 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL B:402;
C:402;
Invalid;
Invalid;
none;
none;
submit data
35.453 Cl [Cl-]
ATP D:500;
A:500;
B:401;
C:401;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
507.181 C10 H16 N5 O13 P3 c1nc(...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LVP 2.5 Å EC: 2.7.11.1 HUMAN PDK1 KINASE DOMAIN IN COMPLEX WITH AN HM-PEPTIDE BOUND PIF-POCKET HOMO SAPIENS PROTEIN KINASE ALLOSTERIC REGULATION SMALL COMPOUNDS PIF-TRANSFERASE
Ref.: BIDIRECTIONAL ALLOSTERIC COMMUNICATION BETWEEN THE ATP-BINDING SITE AND THE REGULATORY PIF POCKET IN P PROTEIN KINASE. CELL CHEM BIOL V. 23 1193 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 5LVP - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 5LVP - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 5LVP - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ATP; Similar ligands found: 422
No: Ligand ECFP6 Tc MDL keys Tc
1 HEJ 1 1
2 ATP 1 1
3 5FA 0.985507 1
4 AQP 0.985507 1
5 AP5 0.927536 0.971831
6 B4P 0.927536 0.971831
7 BA3 0.913043 0.971831
8 ADP 0.9 1
9 A2D 0.884058 0.971831
10 AGS 0.84 0.945946
11 SAP 0.84 0.945946
12 6YZ 0.833333 0.972222
13 AT4 0.810811 0.958904
14 AN2 0.810811 0.985915
15 25L 0.809524 0.985915
16 AR6 0.802632 0.971831
17 APR 0.802632 0.971831
18 M33 0.8 0.958333
19 ACQ 0.794872 0.972222
20 TAT 0.794872 0.958904
21 T99 0.794872 0.958904
22 AD9 0.792208 0.972222
23 ACP 0.789474 0.972222
24 AMP 0.788732 0.971429
25 A 0.788732 0.971429
26 ANP 0.772152 0.972222
27 CA0 0.753247 0.945205
28 ADX 0.753247 0.873418
29 A22 0.746988 0.985915
30 50T 0.74359 0.958333
31 PRX 0.734177 0.893333
32 APC 0.734177 0.958904
33 ABM 0.733333 0.917808
34 ATF 0.731707 0.958904
35 ITT 0.730769 0.943662
36 7D4 0.730769 0.905405
37 ADQ 0.729412 0.945205
38 A3R 0.729412 0.907895
39 AP2 0.714286 0.958904
40 A12 0.714286 0.958904
41 A1R 0.709302 0.907895
42 SRA 0.706667 0.918919
43 5AL 0.698795 0.931507
44 HFD 0.695122 0.945946
45 9X8 0.693182 0.92
46 OAD 0.693182 0.945205
47 AU1 0.6875 0.972222
48 SRP 0.682353 0.906667
49 G5P 0.680851 0.921053
50 25A 0.678161 0.971831
51 3OD 0.677778 0.945205
52 4AD 0.670455 0.92
53 G3A 0.670213 0.921053
54 00A 0.662921 0.883117
55 RBY 0.662651 0.932432
56 ADP PO3 0.662651 0.943662
57 ADV 0.662651 0.932432
58 BIS 0.659341 0.933333
59 8QN 0.659091 0.931507
60 5SV 0.659091 0.848101
61 OOB 0.659091 0.931507
62 GTA 0.65625 0.886076
63 UP5 0.653061 0.92
64 AMO 0.651685 0.932432
65 PAJ 0.651685 0.884615
66 2A5 0.650602 0.918919
67 MAP 0.647727 0.945946
68 3AT 0.647059 0.971831
69 AHX 0.644444 0.896104
70 DLL 0.644444 0.931507
71 ATR 0.642857 0.971429
72 PAP 0.642857 0.985714
73 PTJ 0.641304 0.896104
74 7D3 0.6375 0.905405
75 3UK 0.637363 0.918919
76 SON 0.634146 0.932432
77 A4P 0.633663 0.843373
78 ALF ADP 0.632184 0.87013
79 ADP ALF 0.632184 0.87013
80 PR8 0.630435 0.85
81 WAQ 0.630435 0.883117
82 LAD 0.630435 0.860759
83 B5V 0.630435 0.906667
84 AFH 0.628866 0.884615
85 LMS 0.628205 0.82716
86 GAP 0.627907 0.893333
87 DTP 0.627907 0.905405
88 VO4 ADP 0.625 0.931507
89 ADP VO4 0.625 0.931507
90 TXA 0.623656 0.932432
91 ME8 0.623656 0.839506
92 1ZZ 0.623656 0.839506
93 NB8 0.623656 0.896104
94 FYA 0.623656 0.905405
95 DQV 0.622449 0.958333
96 T5A 0.621359 0.841463
97 ADN 0.619718 0.84507
98 RAB 0.619718 0.84507
99 XYA 0.619718 0.84507
100 DAL AMP 0.611111 0.905405
101 9SN 0.610526 0.871795
102 48N 0.61 0.896104
103 AP0 0.607843 0.896104
104 9ZD 0.604396 0.907895
105 9ZA 0.604396 0.907895
106 FA5 0.604167 0.906667
107 B5M 0.604167 0.894737
108 YAP 0.604167 0.894737
109 B5Y 0.604167 0.894737
110 NAI 0.60396 0.907895
111 6V0 0.60396 0.896104
112 TXD 0.60396 0.907895
113 DND 0.60396 0.932432
114 NXX 0.60396 0.932432
115 NAX 0.60396 0.873418
116 ADP BMA 0.602151 0.918919
117 A2R 0.6 0.985915
118 OMR 0.598039 0.851852
119 TXE 0.598039 0.907895
120 XAH 0.597938 0.839506
121 7DT 0.593023 0.985714
122 AOC 0.592593 0.821918
123 4UV 0.591837 0.894737
124 DDS 0.590909 0.878378
125 139 0.590476 0.873418
126 CNA 0.584906 0.932432
127 6AD 0.58427 0.909091
128 5AS 0.583333 0.77907
129 5N5 0.581081 0.819444
130 GA7 0.58 0.906667
131 4UU 0.58 0.894737
132 4TC 0.576923 0.896104
133 ADJ 0.575472 0.851852
134 5CD 0.573333 0.805556
135 A4D 0.573333 0.819444
136 RGT 0.571429 0.958904
137 A3P 0.571429 0.971429
138 7D5 0.56962 0.878378
139 LAQ 0.568627 0.839506
140 F2R 0.564815 0.864198
141 80F 0.563636 0.841463
142 YLP 0.563107 0.819277
143 A A 0.5625 0.944444
144 UPA 0.561905 0.907895
145 AV2 0.56044 0.917808
146 COD 0.559633 0.811765
147 4UW 0.557692 0.860759
148 JB6 0.556701 0.883117
149 3AM 0.555556 0.929577
150 ATP A A A 0.555556 0.930556
151 A2P 0.552941 0.957143
152 TYM 0.552381 0.906667
153 NA7 0.552083 0.958904
154 EP4 0.551282 0.753247
155 MYR AMP 0.55102 0.817073
156 PPS 0.549451 0.873418
157 YLC 0.54717 0.839506
158 YLB 0.54717 0.819277
159 NAD 0.545455 0.931507
160 DAT 0.545455 0.905405
161 TYR AMP 0.544554 0.87013
162 G5A 0.544444 0.77907
163 M2T 0.544304 0.734177
164 DTA 0.544304 0.786667
165 3DH 0.54321 0.773333
166 128 0.542857 0.776471
167 AHZ 0.538462 0.817073
168 GTP 0.537634 0.92
169 SSA 0.537634 0.8
170 MTA 0.5375 0.773333
171 IOT 0.537037 0.831325
172 A3D 0.535714 0.918919
173 ARG AMP 0.533981 0.829268
174 7MD 0.533981 0.8625
175 AR6 AR6 0.533981 0.917808
176 YLA 0.53211 0.819277
177 AMP DBH 0.529412 0.893333
178 IMO 0.529412 0.929577
179 TAD 0.528846 0.884615
180 AYB 0.527273 0.809524
181 A5A 0.526882 0.807229
182 HDV 0.526882 0.893333
183 TSB 0.526316 0.819277
184 EAD 0.525424 0.873418
185 2AM 0.52439 0.943662
186 6RE 0.52381 0.759494
187 7DD 0.522727 0.985714
188 V3L 0.521739 0.971831
189 AVV 0.520833 0.896104
190 BTX 0.517857 0.841463
191 NAE 0.517241 0.894737
192 52H 0.515789 0.77907
193 54H 0.515789 0.788235
194 VMS 0.515789 0.788235
195 NSS 0.515464 0.8
196 BT5 0.513274 0.831325
197 NAQ 0.512821 0.871795
198 ZAS 0.511905 0.766234
199 J7C 0.511628 0.769231
200 A3N 0.511628 0.786667
201 5X8 0.511111 0.763158
202 53H 0.510417 0.77907
203 8X1 0.510417 0.752809
204 5CA 0.510417 0.8
205 NVA LMS 0.510204 0.752809
206 ARU 0.510204 0.860759
207 AF3 ADP 3PG 0.509259 0.8375
208 ZID 0.508475 0.918919
209 P1H 0.508197 0.851852
210 OVE 0.505882 0.905405
211 S4M 0.505747 0.666667
212 LEU LMS 0.50505 0.752809
213 LPA AMP 0.504673 0.817073
214 7MC 0.504587 0.841463
215 DZD 0.5 0.884615
216 FB0 0.5 0.804598
217 MAO 0.5 0.759036
218 DSZ 0.5 0.8
219 LSS 0.5 0.761364
220 DSH 0.5 0.725
221 P5A 0.5 0.744444
222 NDE 0.495935 0.932432
223 N0B 0.495798 0.819277
224 M24 0.495726 0.85
225 YLY 0.495726 0.809524
226 NJP 0.495575 0.945946
227 9K8 0.49505 0.714286
228 MGP 0.494737 0.884615
229 6C6 0.494624 0.881579
230 NAJ PZO 0.491379 0.848101
231 0WD 0.491228 0.921053
232 6G0 0.489583 0.884615
233 GJV 0.488636 0.75
234 6FA 0.488189 0.841463
235 5AD 0.486842 0.746479
236 KAA 0.485149 0.752809
237 GSU 0.485149 0.77907
238 71V 0.483146 0.907895
239 NEC 0.482759 0.746667
240 A3G 0.482759 0.8
241 ODP 0.482456 0.909091
242 FAS 0.48062 0.851852
243 FAD 0.48062 0.851852
244 7D7 0.480519 0.743243
245 FDA 0.480315 0.833333
246 N6P 0.48 0.915493
247 2SA 0.479167 0.932432
248 GP3 0.478723 0.921053
249 4TA 0.478261 0.807229
250 SFG 0.478261 0.75
251 G A A A 0.478261 0.871795
252 AMP NAD 0.478261 0.905405
253 NPW 0.477876 0.886076
254 NDP 0.477876 0.921053
255 NDC 0.47619 0.871795
256 YSA 0.47619 0.77907
257 NAJ PYZ 0.475 0.807229
258 MGO 0.474227 0.860759
259 GDP 0.473684 0.92
260 NZQ 0.473684 0.909091
261 TXP 0.473684 0.921053
262 6IA 0.473684 0.8375
263 A7D 0.472527 0.776316
264 SFD 0.469231 0.734043
265 A5D 0.468085 0.786667
266 SA8 0.468085 0.707317
267 ZDA 0.468085 0.864865
268 12D 0.46789 0.785714
269 PGS 0.467391 0.883117
270 MHZ 0.467391 0.697674
271 8PZ 0.466667 0.8
272 62F 0.466165 0.8625
273 DA 0.465909 0.878378
274 D5M 0.465909 0.878378
275 GGZ 0.464646 0.825
276 SAH 0.463158 0.74359
277 SAI 0.463158 0.734177
278 FAY 0.462687 0.8625
279 Y3J 0.4625 0.726027
280 PO4 PO4 A A A A PO4 0.460784 0.902778
281 AAM 0.460674 0.971429
282 RFL 0.459259 0.821429
283 SMM 0.459184 0.686047
284 HF7 0.459184 0.893333
285 AMZ 0.458824 0.916667
286 C2R 0.458824 0.90411
287 SAM 0.458333 0.690476
288 A3S 0.456522 0.810811
289 FNK 0.455224 0.804598
290 U A 0.453782 0.907895
291 7C5 0.453704 0.818182
292 EEM 0.453608 0.690476
293 AAT 0.453608 0.707317
294 XNP 0.452991 0.873418
295 A G 0.452991 0.883117
296 PRT 0.45283 0.931507
297 AIR 0.451219 0.901408
298 62X 0.45098 0.666667
299 DCA 0.45 0.823529
300 ETB 0.45 0.833333
301 GSP 0.45 0.873418
302 U A G G 0.449153 0.883117
303 NIA 0.448276 0.822785
304 A3T 0.446809 0.821918
305 A A A 0.446602 0.905405
306 K15 0.446602 0.682353
307 PUA 0.446281 0.884615
308 6K6 0.445545 0.930556
309 GEK 0.445545 0.7375
310 4YB 0.445455 0.761364
311 S7M 0.444444 0.690476
312 Z5A 0.443548 0.77907
313 1DG 0.443548 0.921053
314 DG1 0.443548 0.921053
315 0T1 0.442623 0.823529
316 COA 0.442623 0.823529
317 WSA 0.442478 0.788235
318 8BR 0.43956 0.906667
319 8Q2 0.438596 0.772727
320 101 0.438202 0.878378
321 IDP 0.4375 0.918919
322 NVA 2AD 0.4375 0.759494
323 9JJ 0.435714 0.8625
324 NAP 0.435484 0.945205
325 APU 0.434783 0.894737
326 A U 0.434783 0.87013
327 7RP 0.433333 0.928571
328 A6D 0.432692 0.722892
329 AMX 0.432 0.833333
330 J7V 0.432 0.833333
331 TAP 0.432 0.907895
332 COS 0.432 0.804598
333 CAO 0.432 0.795455
334 30N 0.432 0.752688
335 V1N 0.431193 0.917808
336 649 0.429825 0.744444
337 P5F 0.429577 0.823529
338 NA0 0.428571 0.932432
339 SCO 0.428571 0.823529
340 CMX 0.428571 0.823529
341 7RA 0.428571 0.957747
342 0UM 0.427184 0.698795
343 GAV 0.427184 0.884615
344 QQY 0.426966 0.815789
345 1RB 0.426966 0.885714
346 ACK 0.426966 0.861111
347 G1R 0.425743 0.907895
348 GCP 0.425743 0.896104
349 FAM 0.425197 0.804598
350 FCX 0.425197 0.795455
351 ACO 0.425197 0.795455
352 GNH 0.424242 0.907895
353 F2N 0.423611 0.813953
354 GKE 0.422018 0.884615
355 GDD 0.422018 0.884615
356 GDC 0.422018 0.884615
357 HAX 0.421875 0.804598
358 3AD 0.421687 0.805556
359 9GM 0.421569 0.896104
360 GNP 0.421569 0.896104
361 FA9 0.42069 0.864198
362 TM1 0.420561 0.77381
363 KB1 0.420561 0.698795
364 H6Y 0.42 0.945205
365 2MC 0.419847 0.769231
366 3KK 0.418605 0.804598
367 FYN 0.418605 0.823529
368 S8M 0.417476 0.759494
369 7L1 0.417323 0.795455
370 2VA 0.416667 0.8
371 26A 0.416667 0.763158
372 NHD 0.416667 0.905405
373 QQX 0.41573 0.805195
374 CA6 0.415385 0.729167
375 OXK 0.415385 0.804598
376 COK 0.415385 0.804598
377 SOP 0.415385 0.804598
378 MCD 0.415385 0.804598
379 YE1 0.413534 0.813953
380 RMB 0.413043 0.873239
381 FAI 0.413043 0.916667
382 AS 0.413043 0.833333
383 CO6 0.412214 0.804598
384 1VU 0.412214 0.795455
385 CMC 0.412214 0.804598
386 NMX 0.412214 0.76087
387 SXZ 0.411215 0.710843
388 ANZ 0.410714 0.8
389 SCA 0.410448 0.804598
390 CAJ 0.409091 0.804598
391 SCD 0.409091 0.823529
392 EO7 0.408602 0.788235
393 D3Y 0.407767 0.789474
394 CC5 0.407407 0.816901
395 KH3 0.40708 0.674419
396 A C A C 0.406504 0.848101
397 SLU 0.406504 0.770115
398 G 0.40625 0.906667
399 5GP 0.40625 0.906667
400 A1S 0.406015 0.804598
401 IVC 0.406015 0.813953
402 MLC 0.406015 0.804598
403 3HC 0.406015 0.813953
404 1HE 0.406015 0.786517
405 BCO 0.406015 0.804598
406 GTG 0.405405 0.886076
407 NMN AMP PO4 0.404959 0.87013
408 3D1 0.404762 0.773333
409 3L1 0.404762 0.773333
410 2BA 0.404255 0.915493
411 CMP 0.404255 0.901408
412 VRT 0.40404 0.769231
413 SO8 0.40404 0.789474
414 MCA 0.402985 0.795455
415 COO 0.402985 0.804598
416 CAA 0.402985 0.813953
417 3NZ 0.401869 0.782051
418 G2R 0.401869 0.884615
419 ZZB 0.4 0.77381
420 2FA 0.4 0.813333
421 MC4 0.4 0.76087
422 2CP 0.4 0.795455
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LVP; Ligand: ATP; Similar sites found with APoc: 455
This union binding pocket(no: 1) in the query (biounit: 5lvp.bio4) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 6E2B PT7 None
2 2YJ0 420 None
3 2P3B 3TL None
4 1SQL GUN 1.36986
5 4G9N NGA 1.3986
6 1E6W NAD 1.53846
7 2VPQ ANP 1.60772
8 5ABH YWN 1.60772
9 1QIN GIP 1.63934
10 3ZV6 NAD 1.77936
11 4B1L FRU 1.81818
12 4U98 ACP 1.92926
13 2HGS ADP 1.92926
14 1OX5 1PR 1.92926
15 4OUJ LBT 1.9544
16 5C1P ADP 1.96078
17 5C1P DAL DAL 1.96078
18 5A5W GUO 1.97628
19 2GQS ADP 2.1097
20 2GQS C2R 2.1097
21 1ONI BEZ 2.17391
22 4K49 HFQ 2.20588
23 5VZ0 ADP 2.2508
24 1VA6 P2S 2.2508
25 1VA6 ADP 2.2508
26 3X01 AMP 2.2508
27 5LIA 6XN 2.2508
28 5XWV NDP 2.2508
29 1P6O HPY 2.48447
30 1TZD ADP 2.57235
31 4OCJ NDG 2.57235
32 3K5I ADP 2.57235
33 4OYA 1VE 2.57235
34 1W2D 4IP 2.57235
35 1W2D ADP 2.57235
36 4PU5 ANP 2.57235
37 3K5I AIR 2.57235
38 1D6H COA 2.57235
39 1E4E ADP 2.57235
40 5ZCT ANP 2.61438
41 3ZS7 ATP 2.66667
42 1Y7P RIP 2.69058
43 5DYO FLU 2.83019
44 4OCV ANP 2.89389
45 4O4F ATP 2.89389
46 4O4F IHP 2.89389
47 5MRH Q9Z 2.89389
48 2AQX ATP 2.89389
49 1M0W ANP 2.89389
50 1T36 ADP 2.89389
51 4PIV NDP 2.89389
52 3WXL ADP 2.89575
53 4RDL FUC GAL NDG FUC 2.92208
54 4ZS4 ATP 2.9316
55 6E8I PTR 2.95858
56 5KBE IPH 3.05677
57 3VNM SDD 3.07167
58 5ETR APC 3.10559
59 5ETR 5RW 3.10559
60 2RDE C2E 3.18725
61 3UDZ ADP 3.21543
62 2V58 LZJ 3.21543
63 1IA9 ANP 3.21543
64 3ETH ATP 3.21543
65 6FL8 ADP 3.21543
66 6FL8 TIY 3.21543
67 4PZ6 GMP 3.21543
68 5KD6 LBU 3.21543
69 3PDT ADP 3.27273
70 3FXU TSU 3.27869
71 3PAK MAN 3.37838
72 3NZ1 3NY 3.44828
73 3ZJX BOG 3.46021
74 1ZTH ADP 3.48837
75 1ZP9 ATP 3.48837
76 6DW2 HD4 3.52941
77 5OES ADP 3.53698
78 3ZXR P3S 3.53698
79 3ZXR IQ1 3.53698
80 5TT6 ATP 3.53698
81 3V4S ADP 3.53698
82 3KAL ADP 3.53698
83 3V4S ATP 3.53698
84 1F52 ADP 3.53698
85 4G5H UD7 3.53698
86 4G5H NAP 3.53698
87 5KJW 53C 3.53698
88 4HPP GLU 3.53698
89 3VPC ADP 3.5461
90 1S68 AMP 3.61446
91 4L4J NAG NAG BMA MAN NAG 3.61991
92 5EJL C2E 3.62903
93 5FS0 5JC 3.79147
94 3TM0 ANP 3.80228
95 3TM0 B31 3.80228
96 2Q7D ANP 3.85852
97 1MJT ITU 3.85852
98 6H3O FAD 3.85852
99 5OLK DTP 3.85852
100 3AFN NAP 3.87597
101 3CBC DBS 4.0404
102 2CFM AMP 4.09982
103 1GSA ADP 4.11392
104 5LXB 7A9 4.13223
105 2BKK ADP 4.14201
106 5EQY 5RA 4.18006
107 1PK8 ATP 4.18006
108 1AUX AGS 4.18006
109 4XYM A12 4.18006
110 4XZ3 ACP 4.18006
111 5TDF ADP 4.18006
112 5AXH GLC GLC GLC GLC 4.18006
113 2GQR ADP 4.21941
114 6CGD AKN 4.2623
115 6CGD GNP 4.2623
116 5LJB RTL 4.44444
117 6GNO XDI 4.44444
118 4YEE 4CQ 4.44444
119 4RT1 C2E 4.46429
120 5Z2L NDP 4.4898
121 1EHI ADP 4.50161
122 3WO0 ALA 4.50161
123 3WO0 ADP 4.50161
124 3KJS NAP 4.50161
125 4B7X NAP 4.50161
126 3HQP OXL 4.50161
127 1JG3 ADN 4.68085
128 5YK1 ANP 4.82315
129 3WVR AMP 4.82315
130 1SDW IYT 4.82315
131 2B56 U5P 4.82315
132 4WOE 3S5 4.82315
133 5G48 1FL 4.82315
134 5FLJ QUE 4.83871
135 4R78 AMP 4.85437
136 5C8W PCG 4.8951
137 5YJS SAL 5.12821
138 3LVW GSH 5.14469
139 1Z2P I3S 5.14469
140 1Z2P ACP 5.14469
141 5T96 79J 5.14469
142 3OV6 MK0 5.14469
143 3F5A SIA GAL NAG 5.28455
144 3OJI PYV 5.29101
145 4WOP CTP 5.33333
146 4C5N PXL 5.43478
147 4C5N ACP 5.43478
148 3ORQ ADP 5.46624
149 2YW2 ATP 5.46624
150 1ZB6 GST 5.46624
151 1FFU FAD 5.52147
152 5CPR 539 5.59701
153 4HXY NDP 5.70776
154 2XG5 EC5 5.78035
155 2XG5 EC2 5.78035
156 1U6R IOM 5.78778
157 4TVD BGC 5.78778
158 2WBV SIA 5.82011
159 4NJH 2K8 6.08696
160 4NJH SAM 6.08696
161 3W0O ADP 6.10932
162 3W0O HY0 6.10932
163 3PN1 IVH 6.10932
164 4X3R 686 6.10932
165 5LRT ADP 6.10932
166 4ZOH FAD 6.11511
167 4CQM NAP 6.14754
168 2HKA C3S 6.15385
169 3AB4 THR 6.17978
170 3TDV GDP 6.20915
171 6F97 FAD 6.43087
172 3SJU NDP 6.45161
173 5MW8 ATP 6.75241
174 5VLQ ANP 6.75241
175 5COU ATP 6.75241
176 6C1S EFV 6.75241
177 3KYF 5GP 5GP 6.92641
178 2YG2 S1P 6.97674
179 2YG2 FLC 6.97674
180 3SHR CMP 7.02341
181 2PYW ADP 7.07396
182 2YRX AMP 7.07396
183 5AE9 OKO 7.07396
184 6EZ6 C5Z 7.07396
185 3VPB ADP 7.14286
186 1G51 AMP 7.24138
187 2W5P CL8 7.38255
188 5I35 ANP 7.3955
189 4RF7 ARG 7.3955
190 4FE2 AIR 7.45098
191 4FE2 ADP 7.45098
192 4FMJ SIA GAL 7.61246
193 4FMJ SIA 7.61246
194 1ZEM NAD 7.63359
195 4OAV ACP 7.71704
196 5FJN FAD 7.71704
197 5FJN BE2 7.71704
198 5I39 FAD 7.71704
199 1TQP ATP 7.80142
200 1IOW ADP 7.84314
201 1IOW PHY 7.84314
202 4O1P ANP 8.03859
203 5LXT ACP 8.07292
204 3M3E GAL A2G NPO 8.07453
205 2ZL7 FUC GAL NGA 8.13559
206 2QX0 PH2 8.1761
207 2Y88 2ER 8.19672
208 5T9C G3P 8.20895
209 2FR6 URI 8.21918
210 2FR6 CTN 8.21918
211 4GYI ADP 8.36013
212 3DNT ATP 8.36013
213 5C4L 4XR 8.68167
214 2PUL ACP 8.68167
215 5C4L SIS 8.68167
216 3UG4 AHR 8.68167
217 4DFU QUE 8.68167
218 3E7S AT2 8.68167
219 4LO2 GAL BGC 8.84354
220 4NZN 2OU 9.09091
221 4NZN ANP 9.09091
222 3H0L ADP 9.57447
223 3B6R CRN 9.6463
224 2A8Y MTA 9.6463
225 2QF7 AGS 9.6463
226 5K2M ADP 9.89011
227 1RZ1 NAD 9.93789
228 6AM8 PLT 9.96785
229 3HUJ AGH 10.101
230 5Y4R C2E 10.3448
231 1I82 BGC BGC 10.582
232 5XLY C2E 11.2782
233 3LQV ADE 11.3043
234 4R38 RBF 11.4286
235 4AZW ATP 11.5756
236 1OBD ATP 11.7647
237 4Q5H ANP 11.8421
238 1GT4 UNA 12.5786
239 2CUL FAD 13.7931
240 3HAV ATP 14.0468
241 1KJ8 GAR 14.1479
242 1KJ8 ATP 14.1479
243 3VPD ANP 14.5907
244 1QY1 PRZ 15.5172
245 5KO1 6UY 15.5477
246 3TII ANP 15.7556
247 3KO0 TFP 16.8317
248 3VHE 42Q 17.6849
249 5GZ9 ANP 17.7049
250 2IF8 ADP 18.328
251 4CS9 AMP 19.0476
252 2BOS GLA GAL 19.1176
253 4XMF HSM 20
254 6FYL 3NG 20.5788
255 3VSV XYS 21.2219
256 3H9R TAK 21.865
257 6GIN IR2 22.5914
258 5DZT AMP 23.1511
259 2QLU ADE 23.7942
260 5VC5 96M 24.9135
261 5CKW ANP 25.0804
262 3KMW ATP 25.0923
263 5C03 AGS 26.3666
264 4IX4 ADP 26.3666
265 4WOV 3SM 26.3666
266 4WW7 AMP 26.6667
267 2J0B UDP 26.6667
268 3RG9 WRA 26.6667
269 3RG9 NDP 26.6667
270 3NW7 LGV 28.3388
271 5JFS 6K0 28.5714
272 4FL3 ANP 28.9389
273 5OKT 9XK 28.9389
274 1K3A ACP 29.097
275 5WO4 B7V 29.1391
276 4GJ3 0XP 29.1391
277 4H3P ANP 29.2605
278 3VRY B43 29.2605
279 4QTB 38Z 29.582
280 5EOB 5QQ 29.582
281 3C1X CKK 29.582
282 1OPK P16 29.582
283 5BVE 4VG 29.582
284 3LXN MI1 29.9035
285 3GNI ATP 29.9035
286 5DBX ANP 29.9035
287 3UIM ANP 29.9035
288 1Y57 MPZ 29.9035
289 4KBA 1QM 29.9035
290 1IR3 ANP 30.0654
291 4H3Q ANP 30.2251
292 5MY8 RXZ 30.2251
293 4E1Z 0MX 30.2405
294 4AT3 LTI 30.4348
295 5JKG 6LF 30.5466
296 5WNL STU 30.5466
297 4E93 GUI 30.5466
298 6ES0 BW8 30.5466
299 6C7Y ADP 30.7692
300 4Y93 746 30.8682
301 3PP0 03Q 30.8682
302 5T8O 76Z 30.8682
303 2CSN CKI 30.9764
304 6FYV 3NG 31.1897
305 1VJY 460 31.5113
306 5U6C 7YS 31.5113
307 3G5D 1N1 31.8182
308 4IDT T28 31.8328
309 5CEO 50D 32
310 5X8I SQZ 32.1543
311 5HCY 60D 32.1543
312 6G33 5ID 32.1543
313 4Y85 499 32.2289
314 5JGA 6KC 32.4759
315 5NKB 8ZT 32.6797
316 4YMJ 4EJ 32.8947
317 5UR1 YY9 33.119
318 5USZ SKE 33.218
319 3E8N VRA 33.3333
320 3E8N ATP 33.3333
321 3SLS ANP 33.3333
322 4CLI 5P8 33.3333
323 4XH0 ADP 33.3333
324 1I7L ATP 33.3333
325 2IO8 ADP 33.3333
326 6GWR FEW 33.3333
327 3I0O ADP 33.3333
328 2R7K AMZ 33.3333
329 2R7K ACP 33.3333
330 5IM3 DTP 33.3333
331 1COY FAD 33.3333
332 4CIB 7UZ 33.3333
333 4AZ3 S35 33.3333
334 4AG8 AXI 33.4405
335 4ASE AV9 33.4405
336 5QIN J2V 33.4405
337 2OO8 RAJ 33.4405
338 4CSV STI 33.4545
339 3PLS ANP 33.557
340 2HK5 1BM 33.7037
341 3RI1 3RH 33.7621
342 5MJA 7O3 33.7705
343 2OFV 242 33.935
344 3SXS PP2 33.9552
345 2PVF ACP 34.0836
346 5N87 N66 34.0836
347 3LXK MI1 34.0836
348 4P5Z Q7M 34.0836
349 1JPA ANP 34.0836
350 1U59 STU 34.1463
351 3SRV S19 34.296
352 5TO8 7FM 34.3972
353 3GQI ACP 34.4051
354 3HMO STU 34.4051
355 5ZTN CUR 34.4051
356 6GU6 1QK 34.4371
357 5HQ0 LZ9 34.4371
358 2XVD AS6 34.4371
359 5HES 032 34.5277
360 4TWP AXI 34.6863
361 4UXL 5P8 34.7267
362 6GQM F8H 34.7267
363 4F4P 0SB 34.7985
364 4CRL C1I 35.0482
365 4EWH T77 35.2727
366 4RFM 3P6 35.3383
367 1U5R ATP 35.3698
368 2A19 ANP 35.5634
369 2X2M X2M 35.6913
370 5Y86 HRM 36.0129
371 4U0I 0LI 36.0129
372 5FBN 5WF 36.5314
373 2Y6O 1N1 36.7698
374 2WU6 DKI 36.9775
375 3KRL KRL 36.9775
376 4QMN DB8 36.9775
377 5H2U 1N1 37.0787
378 6CZ3 FLJ 37.5
379 3EKK GS2 37.785
380 3BU5 ATP 37.9085
381 6A1G 9OL 37.9421
382 3ALN ANP 38.2637
383 5EH0 5NW 38.7597
384 3GC0 AMP 38.9058
385 5AWM ANP 38.9068
386 1V0O INR 39.5833
387 4K33 ACP 40
388 5LPZ ADP 40
389 4BTK DTQ 40
390 5LPB ADP 40
391 4CYI ATP 40
392 2VQD AP2 40
393 2QK4 ATP 40
394 4MV1 ADP 40
395 3VOT ADP 40
396 5NJI 8Z2 40
397 5TA6 79D 40.5145
398 4BHN BH9 40.5145
399 4I6H 1C8 40.5844
400 1BYG STU 40.6475
401 3IGO ANP 40.836
402 1OUK 084 40.836
403 4LOO SB4 40.836
404 3FC2 IBI 40.8955
405 3TTI KBI 41.1576
406 2B9F ADP 41.1576
407 2B9I ADP 41.1576
408 2B9J ADP 41.1576
409 4WHZ 3NL 41.1576
410 3PTG 932 41.1576
411 2B9H ADP 41.1576
412 3BZ3 YAM 41.3043
413 3HZT J60 41.4791
414 2VZ6 FEF 41.4791
415 5EKO N17 41.4791
416 4YZC STU 41.4791
417 4AU8 Z3R 41.5541
418 4NST ADP 41.8006
419 3E7O 35F 41.8006
420 4UX9 ANP 42.1222
421 6E2O S0L 42.3729
422 4IZY 1J2 42.4437
423 2BPM 529 42.7184
424 2V7O DRN 42.7653
425 1CM8 ANP 42.7653
426 1UNH IXM 42.8082
427 3O0G 3O0 42.8082
428 6CMJ F6J 43.0868
429 2WEL K88 43.0868
430 4CFU 2WC 43.2343
431 4AUA 4AU 43.3225
432 6GUE FB8 43.3775
433 4BCM T7Z 43.5216
434 4BCQ TJF 43.5216
435 4BCN T9N 43.6667
436 3GC8 B45 44.0514
437 2XMY CDK 44.2953
438 5LMK 6ZK 44.4444
439 2VN9 GVD 44.5183
440 2WEI VGG 44.9477
441 5EFQ ADP 45.3376
442 2F57 23D 45.3376
443 2ZV2 609 45.6376
444 1O9U ADZ 45.6592
445 1ZY5 ANP 46.2046
446 4ONA UW1 46.3022
447 3F7Z 34O 46.6238
448 3ZRM ZRM 46.6238
449 2H8H H8H 46.6667
450 2JLD AG1 46.9453
451 4NM5 ADP 46.9453
452 1PHK ATP 47.9866
453 4PNI KQQ 48.5531
454 4L9I 8PR 48.5531
455 4FG8 ATP 49.8392
Pocket No.: 2; Query (leader) PDB : 5LVP; Ligand: ATP; Similar sites found with APoc: 65
This union binding pocket(no: 2) in the query (biounit: 5lvp.bio2) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 5G6U TRP 1.91571
2 1YFS ALA 1.92926
3 4Y30 49L 1.92926
4 4Y30 SAH 1.92926
5 5WKR NAR 2.24215
6 2Z49 AMG 2.2508
7 4DP3 MMV 2.2508
8 1F1V DHY 2.2508
9 4DP3 NDP 2.2508
10 6ARJ BW4 2.57235
11 3ZGJ RMN 2.57235
12 6ARJ SAH 2.57235
13 5B4T 3HR 2.69231
14 5B4T NAD 2.69231
15 3A4V PYR 2.83912
16 3A4V NAD 2.83912
17 1IY8 NAD 2.99625
18 1I1D 16G 3.10559
19 1SU2 ATP 3.14465
20 3QWI CUE 3.33333
21 2RI1 GLP 3.40426
22 2XZ9 PYR 3.53698
23 3I7V ATP 3.73134
24 2WTX UDP 3.85852
25 2WTX VDO 3.85852
26 6DZN AE3 3.9823
27 4XF6 ADP 4.0293
28 2J62 GSZ 4.18006
29 6CI9 NAP 4.2471
30 5TBM 79A 4.34783
31 3H2K BOG 4.82315
32 5TOW NAI 5.14469
33 5TOW ADN 5.14469
34 1ZB6 DIN 5.46624
35 2ZAT NAP 5.46624
36 1BGQ RDC 5.77778
37 2P3C 3TL 6.06061
38 2QS8 MET 6.10932
39 5XWC NAP 6.10932
40 5XWC 2IT 6.10932
41 5XWC 8GL 6.10932
42 6G47 SIA 6.2201
43 2X34 UQ8 6.62983
44 2X32 OTP 6.70391
45 4FHD 0TT 6.75241
46 4FHD EEM 6.75241
47 4K37 SAM 6.75241
48 1JJE BYS 8.03859
49 3ZXE PGZ 8.68167
50 4GN8 ASO 9.36455
51 3KTA AP5 9.89011
52 3UOY FAD 9.96785
53 3UOY NAP 9.96785
54 5Y72 DST 10.9325
55 1CBK ROI 13.125
56 5A89 FMN 13.4615
57 3OCP CMP 14.3885
58 2BOS GLA GAL GLC 19.1176
59 2GTF P1R 20
60 1KDK DHT 26.6667
61 5H68 AGS 26.6667
62 3E85 BSU 26.6667
63 3HRD FAD 26.6667
64 3FSM 2NC 33.3333
65 1VQ2 DDN 46.6667
Pocket No.: 3; Query (leader) PDB : 5LVP; Ligand: ATP; Similar sites found with APoc: 43
This union binding pocket(no: 3) in the query (biounit: 5lvp.bio1) has 17 residues
No: Leader PDB Ligand Sequence Similarity
1 4J6O CIT 1.51515
2 1EDO NAP 1.63934
3 3VY6 BGC BGC 2.12766
4 4CTA ATP 2.2508
5 2C29 NAP 2.37389
6 1H5Q NAP 2.64151
7 2DTX BMA 2.65152
8 5GUD NDP 2.89389
9 1T26 NAI 2.89389
10 1T26 GBD 2.89389
11 5GUD 2IT 2.89389
12 2VD9 IN5 2.89389
13 2VD9 EPC 2.89389
14 5GT9 NAP 3.04183
15 5KD6 6C7 3.21543
16 4B0T ADP 3.53698
17 1KR3 113 3.87931
18 2Q2V NAD 3.92157
19 4XF6 LIP 4.0293
20 4XF6 INS 4.0293
21 5WUW NAP 4.52962
22 1XVB BHL 5.46624
23 4IE6 UN9 5.46624
24 4HXY ACA 5.70776
25 2VQ5 HBA 5.97015
26 3L9R L9R 6.00707
27 4J1Q NDP 6.10932
28 5GWT NAD 6.11511
29 5GWT SIN 6.11511
30 4O33 3PG 6.43087
31 4O33 TZN 6.43087
32 1RM6 FAD 6.43087
33 5G4L NDP 7.34266
34 3A28 NAD 8.13953
35 1DZK PRZ 8.9172
36 1XEX ATP 10.4396
37 5ML3 DL3 24.8322
38 2V2V V12 26.6667
39 1F5F DHT 26.6667
40 4A0S NAP 26.6667
41 3KA2 2NC 33.3333
42 5OJI ISN 40
43 5OJI NAP 40
Pocket No.: 4; Query (leader) PDB : 5LVP; Ligand: ATP; Similar sites found with APoc: 27
This union binding pocket(no: 4) in the query (biounit: 5lvp.bio3) has 18 residues
No: Leader PDB Ligand Sequence Similarity
1 5HV7 RBL 1.60772
2 1EK6 NAI 1.92926
3 1EK6 UPG 1.92926
4 1GQG DCD 1.92926
5 2QL9 CIT 2.31214
6 4LY9 S6P 2.57235
7 4LY9 1YY 2.57235
8 5NM7 GLY 3.38346
9 3A7R LAQ 3.53698
10 4W6Z ETF 3.85852
11 4UWH JXM 5.14469
12 5UR6 8KM 5.52486
13 3LXI CAM 5.78778
14 5E65 5N6 GAL 5.78778
15 5E62 Z3Q GAL 5N6 5.78778
16 4OIT MAN 6.19469
17 5HP8 PYR 6.45161
18 4NG2 OHN 7.06522
19 6D6L FY4 7.64706
20 3KIF GDL 8.49057
21 4K55 H6P 8.87097
22 4KM2 ATR 8.93855
23 1I1E DM2 9.32476
24 5A89 ADP 13.4615
25 1VRP IOM 14.791
26 6EOM ALA LYS 26.6667
27 1T3Q FAD 33.3333
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