Receptor
PDB id Resolution Class Description Source Keywords
5LWY 2.4 Å NON-ENZYME: SIGNAL_HORMONE REVISED CRYSTAL STRUCTURE OF THE HUMAN ADIPONECTIN RECEPTOR COMPLEX WITH A C18 FREE FATTY ACID HOMO SAPIENS PROGESTIN AND ADIPOQ RECEPTOR FAMILY INTEGRAL MEMBRANE PROTCERAMIDASE MEMBRANE PROTEIN
Ref.: STRUCTURAL INSIGHTS INTO ADIPONECTIN RECEPTORS SUGG CERAMIDASE ACTIVITY. NATURE V. 6 120 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ZN A:401;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
GOL L:201;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
OLB A:407;
A:403;
A:405;
A:408;
A:402;
A:404;
A:409;
A:406;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
356.54 C21 H40 O4 CCCCC...
OLA A:410;
Valid;
none;
submit data
282.461 C18 H34 O2 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5LWY 2.4 Å NON-ENZYME: SIGNAL_HORMONE REVISED CRYSTAL STRUCTURE OF THE HUMAN ADIPONECTIN RECEPTOR COMPLEX WITH A C18 FREE FATTY ACID HOMO SAPIENS PROGESTIN AND ADIPOQ RECEPTOR FAMILY INTEGRAL MEMBRANE PROTCERAMIDASE MEMBRANE PROTEIN
Ref.: STRUCTURAL INSIGHTS INTO ADIPONECTIN RECEPTORS SUGG CERAMIDASE ACTIVITY. NATURE V. 6 120 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 5LWY - OLB C21 H40 O4 CCCCCCCC/C....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 196 families.
1 5LWY - OLB C21 H40 O4 CCCCCCCC/C....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 171 families.
1 5LWY - OLB C21 H40 O4 CCCCCCCC/C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: OLB; Similar ligands found: 63
No: Ligand ECFP6 Tc MDL keys Tc
1 OLB 1 1
2 OLC 1 1
3 MVC 0.958333 1
4 78M 0.9375 1
5 78N 0.9375 1
6 GYM 0.808511 0.969697
7 NKP 0.683333 0.688889
8 1AG 0.62069 1
9 PGW 0.597222 0.733333
10 PGV 0.589041 0.733333
11 DR9 0.589041 0.733333
12 P6L 0.581081 0.733333
13 S12 0.577465 0.627451
14 OZ2 0.573333 0.733333
15 PGM 0.571429 0.727273
16 P3A 0.558442 0.733333
17 NKN 0.533333 0.666667
18 L2C 0.525424 0.828571
19 DGA 0.525424 0.828571
20 DDR 0.525424 0.828571
21 OLA 0.519231 0.617647
22 NER 0.519231 0.617647
23 ELA 0.519231 0.617647
24 L9Q 0.5 0.603774
25 LOP 0.5 0.603774
26 VCA 0.490566 0.617647
27 PAM 0.490566 0.617647
28 ZPE 0.487179 0.603774
29 MPG 0.483871 0.941176
30 TGL 0.482759 0.722222
31 LHG 0.472222 0.711111
32 PGT 0.472222 0.711111
33 1O2 0.46988 0.711111
34 LBR 0.469697 0.805556
35 B7N 0.469136 0.607843
36 PVC 0.46875 0.815789
37 3TF 0.464286 0.711111
38 RCL 0.453125 0.705882
39 G2A 0.446429 0.882353
40 2JT 0.446429 0.882353
41 GP7 0.435294 0.603774
42 2WA 0.432836 0.885714
43 3WM 0.432836 0.885714
44 2WM 0.432836 0.885714
45 1L2 0.428571 0.711111
46 PGK 0.426829 0.666667
47 3PH 0.426471 0.630435
48 6PH 0.426471 0.630435
49 7PH 0.426471 0.630435
50 LPP 0.426471 0.630435
51 AGA 0.421053 0.711111
52 PX2 0.42029 0.608696
53 7P9 0.42029 0.630435
54 SPL 0.41791 0.608696
55 18C 0.41791 0.608696
56 16C 0.41791 0.608696
57 PEK 0.411765 0.603774
58 VA 0.40678 0.617647
59 GGD 0.40625 0.680851
60 8ND 0.405797 0.636364
61 CD4 0.405405 0.666667
62 EIC 0.4 0.647059
63 CDL 0.4 0.622222
Ligand no: 2; Ligand: OLA; Similar ligands found: 51
No: Ligand ECFP6 Tc MDL keys Tc
1 NER 1 1
2 OLA 1 1
3 ELA 1 1
4 PAM 0.939394 1
5 VCA 0.939394 1
6 MYZ 0.852941 0.954545
7 EIC 0.725 0.956522
8 STE 0.71875 0.954545
9 MYR 0.71875 0.954545
10 F23 0.71875 0.954545
11 DAO 0.71875 0.954545
12 11A 0.71875 0.954545
13 TDA 0.71875 0.954545
14 KNA 0.71875 0.954545
15 F15 0.71875 0.954545
16 DKA 0.71875 0.954545
17 DCR 0.71875 0.954545
18 PLM 0.71875 0.954545
19 OCA 0.6875 0.954545
20 ODD 0.675 0.956522
21 RCL 0.625 0.88
22 LNL 0.613636 0.869565
23 SHV 0.606061 0.909091
24 KTC 0.605263 0.84
25 3X1 0.564103 0.863636
26 ODT 0.555556 0.826087
27 T25 0.54717 0.709677
28 AZ1 0.53125 0.615385
29 6NA 0.529412 0.863636
30 10Y 0.529412 0.645161
31 10X 0.529412 0.645161
32 243 0.519231 0.846154
33 OLC 0.519231 0.617647
34 OLB 0.519231 0.617647
35 MVC 0.490566 0.617647
36 ACD 0.488889 0.956522
37 VA 0.478261 0.692308
38 3LA 0.47619 0.769231
39 78N 0.471698 0.617647
40 78M 0.471698 0.617647
41 EOD 0.468085 0.677419
42 MPG 0.45283 0.617647
43 14V 0.444444 0.714286
44 LEA 0.441176 0.772727
45 T24 0.438596 0.769231
46 BRC 0.435897 0.64
47 14U 0.431818 0.678571
48 M12 0.428571 0.833333
49 UNA 0.421053 0.636364
50 8YP 0.421053 0.636364
51 OCD 0.421053 0.636364
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5lwy.bio1) has 3 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5lwy.bio1) has 6 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 5lwy.bio1) has 11 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: 123
This union binding pocket(no: 4) in the query (biounit: 5lwy.bio1) has 18 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5K52 OCD 0.004886 0.42196 2.26415
2 1JR8 FAD 0.009075 0.41112 2.5641
3 5V4R MGT 0.00574 0.44273 3.73832
4 5G3U ITW 0.01647 0.42281 4.6729
5 2HJ3 FAD 0.01166 0.40436 4.8
6 5CSD ACD 0.02045 0.41269 5.03145
7 1U3R 338 0.001285 0.44272 5.60748
8 3B6C SDN 0.003947 0.43506 5.60748
9 4FHT DHB 0.005561 0.43002 5.60748
10 2I0G I0G 0.01406 0.42955 5.60748
11 1YYE 196 0.0022 0.42754 5.60748
12 3E85 BSU 0.03134 0.4034 5.6962
13 3EE4 MYR 0.02883 0.41125 5.88235
14 1HN4 MJI 0.01614 0.43543 6.10687
15 4MRP GSH 0.004457 0.42406 6.50685
16 5AZC PGT 0.01136 0.45032 6.54206
17 3HP9 CF1 0.00499 0.43905 6.72269
18 4O1Z MXM 0.0001517 0.43853 6.72269
19 1M13 HYF 0.006869 0.42833 6.72269
20 3ZLR X0B 0.01722 0.41442 6.72269
21 3QKD HI0 0.01537 0.40037 6.72269
22 4RC8 STE 0.004656 0.42468 6.75676
23 4O4Z N2O 0.007221 0.42228 7.14286
24 3KDU NKS 0.0028 0.45449 7.22022
25 3W54 RNB 0.001343 0.44185 7.47664
26 1F0X FAD 0.0273 0.40641 7.47664
27 2P54 735 0.01638 0.40354 7.49064
28 4XNV BUR 0.02863 0.40019 7.53425
29 2LBD REA 0.0005601 0.47136 7.56302
30 1FCZ 156 0.0004076 0.41019 7.56302
31 1GNI OLA 0.04161 0.44632 8.21918
32 4V3I ASP LEU THR ARG PRO 0.002583 0.45534 8.41121
33 3G9E RO7 0.00335 0.44598 8.41121
34 3WYJ H78 0.02186 0.42789 8.41121
35 5EW9 5VC 0.04017 0.42781 8.41121
36 1DB1 VDX 0.007715 0.42711 8.41121
37 5ECP JAA 0.01836 0.41691 8.41121
38 5ECP MET 0.01836 0.41691 8.41121
39 3ET3 ET1 0.01323 0.40008 8.41121
40 2Z7I 742 0.0179 0.43427 8.56164
41 4DXJ IPE 0.007697 0.42593 9.2437
42 4DXJ 0M9 0.007366 0.42428 9.2437
43 5D59 78M 0.03242 0.4062 9.2437
44 4M8E 29V 0.002475 0.43751 9.34579
45 3LLI FAD 0.005261 0.42849 9.34579
46 1YOK P6L 0.01849 0.41186 9.34579
47 5UI2 EQ3 0.01685 0.41169 9.34579
48 5HGR 45D 0.0197 0.40944 9.34579
49 4ZBR NPS 0.02018 0.40558 9.34579
50 4ZBR DIF 0.0213 0.40558 9.34579
51 1FBY REA 0.01622 0.40082 9.34579
52 1NP7 FAD 0.02145 0.40187 10.084
53 2E9L BGC 0.03376 0.40084 10.084
54 2E9L OLA 0.03376 0.40084 10.084
55 2E9L PLM 0.03229 0.40084 10.084
56 2QA8 GEN 0.0009687 0.44358 10.2804
57 2QZO KN1 0.001679 0.40744 10.2804
58 1TV5 N8E 0.001885 0.46038 10.6164
59 4ORM FMN 0.02998 0.42066 10.6164
60 4ORM 2V6 0.02998 0.42066 10.6164
61 4ORM ORO 0.02998 0.42066 10.6164
62 1RSG FAD 0.009091 0.43408 10.9244
63 4OYA 1VE 0.04058 0.41311 10.9244
64 3QCP FAD 0.003416 0.4359 11.215
65 4B5P ACO 0.01749 0.40355 11.215
66 3RUU 37G 0.003742 0.43701 12.1495
67 5HCV 60R 0.001089 0.40871 12.1495
68 2A3I C0R 0.001278 0.40076 12.1495
69 4MNS 2AX 0.009154 0.43743 12.5786
70 2VZZ SCA 0.01117 0.41557 12.605
71 3LDW ZOL 0.008797 0.42312 13.0841
72 5XDT MB3 0.016 0.41279 13.0841
73 3LDW IPE 0.01427 0.40779 13.0841
74 2GAG FAD 0.04705 0.40032 13.0841
75 2P1C GG3 0.006464 0.42701 13.3562
76 5LIA 6XN 0.03697 0.41701 13.4454
77 4LY9 1YY 0.02953 0.41071 13.4454
78 4LY9 S6P 0.02992 0.40963 13.4454
79 2XXP DSL 0.02568 0.42656 14.0187
80 5B4B LP5 0.001115 0.46366 14.2857
81 4IAE 1DX 0.01254 0.41909 14.2857
82 2D5Z L35 0.04749 0.41591 14.3836
83 1YUC EPH 0.005312 0.43245 14.9533
84 1XVB BHL 0.009174 0.43003 14.9533
85 5IR4 ZPE 0.01236 0.42645 15.126
86 5IKR ID8 0.002297 0.43126 15.8879
87 2Q2Y ADP 0.02049 0.41265 15.8879
88 2Q2Y MKR 0.01959 0.41265 15.8879
89 3ANP DAO 0.01165 0.40914 15.8879
90 3ANP DCC 0.01498 0.40813 15.8879
91 1XRO LEU 0.02302 0.4061 15.9664
92 4OMJ 2TX 0.02485 0.40229 15.9664
93 4QWT ACD 0.007788 0.41892 16.4384
94 5BVE 4VG 0.0375 0.41309 16.8067
95 1YRE COA 0.009491 0.40303 16.8067
96 4HIA FMN 0.01444 0.41609 17.0455
97 2PRG BRL 0.009433 0.40315 17.0455
98 3L9R L9Q 0.02147 0.40652 17.6471
99 5U98 1KX 0.009511 0.44348 18.1818
100 5AAV GW5 0.0006704 0.50042 18.6916
101 2QE4 JJ3 0.009728 0.43852 18.6916
102 3T58 FAD 0.01503 0.41059 18.6916
103 5U3B 7TD 0.004686 0.43373 19.3277
104 3KP6 SAL 0.006979 0.43063 19.6262
105 5H94 LYS MET ASN THR GLN PHE THR ALA VAL 0.0496 0.40063 19.6262
106 4XB4 45D 0.00139 0.44922 20.5607
107 1OQC FAD 0.008587 0.41386 21.6
108 1LEK GLU GLN TYR LYS PHE TYR SER VAL 0.02998 0.42125 21.8487
109 3MBG FAD 0.01163 0.41063 23.741
110 4DM8 REA 0.0009964 0.45597 24
111 1FM9 9CR 0.001508 0.44373 24
112 3BEJ MUF 0.00208 0.44105 24
113 1FM9 570 0.0162 0.40903 24
114 4BNU 9KQ 0.01195 0.40551 24.2991
115 2HFP NSI 0.01039 0.40995 28.5714
116 4X6F 3XU 0.0146 0.41999 31.9328
117 5L2J 70E 0.006155 0.45802 33.6134
118 5L2J 6UL 0.005811 0.45802 33.6134
119 4F7E 0SH 0.02435 0.4089 33.6134
120 3UUD EST 0.0009647 0.44366 46.1538
121 3KMR EQN 0.007754 0.409 46.1538
122 3SCM LGN 0.004548 0.45778 47.6636
123 3QUZ QUV 0.007245 0.44506 47.6636
Pocket No.: 5; Query (leader) PDB : 5LWY; Ligand: OLA; Similar sites found: 46
This union binding pocket(no: 5) in the query (biounit: 5lwy.bio1) has 21 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4GFD 0YB 0.002737 0.42509 2.43902
2 5V4R MGT 0.001929 0.46356 3.73832
3 1RQJ RIS 0.008252 0.40555 3.76712
4 4RHP PEF 0.003497 0.40296 5.10638
5 1MRH FMC 0.01531 0.41146 5.60748
6 1OKC CXT 0.001619 0.41437 5.88235
7 5AZC PGT 0.01471 0.43438 6.54206
8 4UNR QZE 0.004101 0.41767 6.66667
9 3ZLR X0B 0.01097 0.41381 6.72269
10 2QES ADE 0.02224 0.40011 6.72269
11 4O4Z N2O 0.02717 0.40827 7.14286
12 4LZB URA 0.01604 0.40128 7.14286
13 4YGM URA 0.007965 0.40089 7.32759
14 5EW9 5VC 0.04113 0.41867 8.41121
15 4C9G CXT 0.002159 0.41718 8.41121
16 3WYJ H78 0.02545 0.41521 8.41121
17 4V3I ASP LEU THR ARG PRO 0.01969 0.40713 8.41121
18 5KF6 NAD 0.01514 0.40295 8.41121
19 4UCC ZKW 0.00953 0.42652 8.58369
20 5FS0 5JC 0.006005 0.42722 9.00474
21 1QCI ADE 0.01419 0.40451 9.16031
22 3H0A D30 0.004479 0.42036 9.34579
23 4XCP PLM 0.02044 0.40309 10
24 5AHS SIN 0.009487 0.42002 10.2804
25 1YXM ADE 0.02447 0.40968 10.2804
26 2WOX NDP 0.01567 0.4045 10.2804
27 1TV5 N8E 0.01482 0.41901 10.6164
28 5HCN DAO 0.01722 0.40885 11.215
29 3WV1 WHH 0.02186 0.40633 11.7647
30 5N18 8HZ 0.01422 0.41429 11.9266
31 5HCY 60D 0.02183 0.40462 11.9863
32 1JNR FAD 0.04351 0.40897 12.1495
33 3KRO DST 0.01064 0.40213 12.605
34 3KRO IPE 0.01064 0.40213 12.605
35 4LY9 S6P 0.01364 0.41693 13.4454
36 4LY9 1YY 0.01421 0.41693 13.4454
37 3G58 988 0.007556 0.41776 14.0187
38 5GWE GWM 0.01246 0.41148 15.126
39 2FV5 541 0.008279 0.41246 16.8067
40 4CQE CQE 0.01807 0.40374 16.8224
41 3GDN HBX 0.02461 0.40932 18.4874
42 3GDN FAD 0.02283 0.40457 18.4874
43 3JRX S1A 0.002838 0.42084 19.3277
44 4BNU 9KQ 0.0005914 0.45245 24.2991
45 3T03 3T0 0.002528 0.40944 33.3333
46 2DYR PGV 0.01262 0.41099 39.2857
Pocket No.: 6; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 5lwy.bio1) has 3 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 5lwy.bio1) has 9 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 5lwy.bio1) has 9 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 5LWY; Ligand: OLB; Similar sites found: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 5lwy.bio1) has 10 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
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