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Receptor
PDB id Resolution Class Description Source Keywords
5MWE 2.02 Å NON-ENZYME: OTHER COMPLEX BETWEEN THE LEUCINE ZIPPER (LZ, RESIDUES 490-567) AN CENTROSOMIN-MOTIF 2 (CM2) DOMAINS OF DROSOPHILA MELANOGASTEC ENTROSOMIN (CNN) DROSOPHILA MELANOGASTER CENTROSOME CENTRIOLE COILED-COIL MITOSIS CELL CYCLE
Ref.: STRUCTURAL BASIS FOR MITOTIC CENTROSOME ASSEMBLY IN CELL V. 169 1078 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
TCE B:1201;
Valid;
Atoms found LESS than expected: % Diff = 0;
submit data
250.186 C9 H15 O6 P C(CP(...
ZN A:1201;
Part of Protein;
none;
submit data
65.409 Zn [Zn+2...
EDO D:601;
C:601;
Invalid;
Invalid;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5MWE 2.02 Å NON-ENZYME: OTHER COMPLEX BETWEEN THE LEUCINE ZIPPER (LZ, RESIDUES 490-567) AN CENTROSOMIN-MOTIF 2 (CM2) DOMAINS OF DROSOPHILA MELANOGASTEC ENTROSOMIN (CNN) DROSOPHILA MELANOGASTER CENTROSOME CENTRIOLE COILED-COIL MITOSIS CELL CYCLE
Ref.: STRUCTURAL BASIS FOR MITOTIC CENTROSOME ASSEMBLY IN CELL V. 169 1078 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5MWE - TCE C9 H15 O6 P C(CP(CCC(=....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 5MWE - TCE C9 H15 O6 P C(CP(CCC(=....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 5MWE - TCE C9 H15 O6 P C(CP(CCC(=....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: TCE; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 TCE 1 1
2 SIN 0.45 0.625
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5MWE; Ligand: TCE; Similar sites found with APoc: 538
This union binding pocket(no: 1) in the query (biounit: 5mwe.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
1 1NU4 MLA None
2 6BYM HC3 None
3 5LX9 OLB None
4 2GWH PCI None
5 3SFI 3SF None
6 4GFD 0YB None
7 5LWY OLA None
8 4COL DTP None
9 6EKZ SNP None
10 5NM7 GLY None
11 2XCG XCG None
12 6GL8 F3Q None
13 2AX9 BHM None
14 4ZGM 32M None
15 4WG0 CHD None
16 3V49 PK0 None
17 3IIS PID None
18 3ROE THM None
19 3GWN FAD None
20 5F1R 42O None
21 5XFV FMN None
22 6CHP F0Y None
23 3E3U NVC None
24 4LAE NAP None
25 4LAE 1VM None
26 1POC GEL None
27 3NT6 COA None
28 3COW 52H None
29 4IAE 1DX None
30 5MT9 SRO None
31 1N9L FMN None
32 2ZFZ ARG None
33 3P9T TCL None
34 1UO5 PIH None
35 2FV5 541 None
36 1UKZ ADP None
37 1MT1 AG2 None
38 5MT9 ARG None
39 4L1F COS None
40 2HJ3 FAD None
41 2JBZ COA None
42 2Z6D FMN None
43 3N7S 3N7 None
44 6MPT C30 None
45 4DXJ 0M9 None
46 4P3H 25G None
47 1N8V BDD None
48 3FS1 ALA ALA LEU ALA ALA LEU LEU ALA ALA None
49 1PCA CIT None
50 4CJX 9L9 None
51 3R9C ECL None
52 4AZJ SEP PLP None
53 1ZEI CRS None
54 1TMX HGX None
55 2EW5 Y12 None
56 1QG6 TCL None
57 1QG6 NAD None
58 4F4S EFO None
59 4GCZ FMN None
60 1S17 GNR None
61 1IZE IVA VAL VAL STA ALA STA None
62 6AYH C3G None
63 3NTA COA None
64 1G27 BB1 None
65 1JQI CAA None
66 4QC6 30N None
67 1N13 AG2 None
68 3KP6 SAL None
69 1UO4 PIH None
70 2I0G I0G 2.46914
71 4XDA ADP 2.46914
72 2YJD YJD 2.46914
73 3VHZ SOG 2.46914
74 3OKI OKI 3.7037
75 5K7H IVC 3.7037
76 3BQD DAY 3.7037
77 5UC1 486 3.7037
78 5G3N X28 3.7037
79 1NHZ 486 3.7037
80 1U3D FAD 3.7037
81 5G5W R8C 3.7037
82 3BEJ MUF 3.7037
83 4P6X HCY 3.7037
84 4LSJ LSJ 3.7037
85 4OIV XX9 3.7037
86 5KBZ 3B2 3.7037
87 4UNR QZE 3.7037
88 4O1Z MXM 4.28571
89 1ZPD CIT 4.28571
90 4ZUL UN1 4.28571
91 2BHZ MAL 4.28571
92 2H7C COA 4.28571
93 3WYJ H78 4.93827
94 3X1M COA 4.93827
95 4CVZ TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 4.93827
96 2PX8 MGT 4.93827
97 2JJK R15 4.93827
98 1LBT T80 4.93827
99 2CIX CEJ 4.93827
100 2EV1 OLA 5.71429
101 5UNJ RJW 5.71429
102 1YUC EPH 5.71429
103 1ZDU P3A 5.71429
104 1YOK P6L 5.71429
105 3KMZ EQO 6.17284
106 1YKD CMP 6.17284
107 5M36 9SZ 6.17284
108 4OPC PGT 6.17284
109 5H94 LYS MET ASN THR GLN PHE THR ALA VAL 6.17284
110 3LLI FAD 6.17284
111 2UW1 GVM 6.17284
112 5UR6 8KM 6.17284
113 1ZED PNP 6.17284
114 5C1M CLR 6.17284
115 5AB7 MLC 6.17284
116 3T50 FMN 6.17284
117 5UGW GSH 6.17284
118 5V3Y 5V8 6.17284
119 5C1M OLC 6.17284
120 5C1M 4VO 6.17284
121 3VRV YSD 7.14286
122 1OVD FMN 7.14286
123 1OVD ORO 7.14286
124 4IS0 1R4 7.14286
125 3TGE TGE 7.14286
126 4M73 SAH 7.14286
127 3R1V AZB 7.14286
128 4M73 M72 7.14286
129 1KY8 NAP 7.14286
130 1NTV ASN PHE ASP ASN PRO VAL TYR ARG LYS THR 7.14286
131 2PX6 DH9 7.14286
132 3WQM B29 7.14286
133 5A8E XTK 7.14286
134 1FK5 OLA 7.40741
135 3FZG SAM 7.40741
136 4QWT ACD 7.40741
137 6CB2 OLC 7.40741
138 4M0R 644 7.40741
139 1NP7 FAD 7.40741
140 3E70 GDP 7.40741
141 1OW4 2AN 7.40741
142 3E7O 35F 7.40741
143 2XN3 ID8 7.40741
144 2B56 U5P 7.40741
145 5AWV GHP 3MY 3FG GHP GHP OMY 3FG NAG MAN 7.40741
146 5AZC PGT 8.57143
147 6ESN BWE 8.57143
148 5NTW 98N 8.57143
149 5B4B LP5 8.57143
150 5X8Q 82R 8.57143
151 2C78 PUL 8.57143
152 5NI5 8YB 8.57143
153 5NTP 98E 8.57143
154 5APK 76E 8.57143
155 5IXK 6EW 8.57143
156 4WPF 3SN 8.57143
157 5DUF G7A 8.57143
158 1GHE ACO 8.57143
159 5IKR ID8 8.57143
160 5E4R NAP 8.57143
161 2Z7I 742 8.57143
162 2E2R 2OH 8.64198
163 5N9T 8QQ 8.64198
164 5ZM0 FAD 8.64198
165 1YMT DR9 8.64198
166 3UR0 SVR 8.64198
167 2Q1H AS4 8.64198
168 4BNU 9KQ 8.64198
169 1YP0 PEF 8.64198
170 1OQC FAD 8.64198
171 4QJR PIZ 8.64198
172 4WGF HX2 8.64198
173 5X93 K87 8.64198
174 1XVB BHL 8.64198
175 2RH1 CLR 8.64198
176 1XVB 3BR 8.64198
177 2WPX ACO 8.64198
178 3SJH LAR 8.64198
179 2XFH CL6 8.64198
180 4Q9M 2ZW 8.64198
181 1ZDT PEF 8.64198
182 3U5S FAD 8.64198
183 3RMK BML 8.64198
184 4Q9M FPP 8.64198
185 3F5K CE5 8.64198
186 5UWA 8ND 8.64198
187 4V1F BQ1 9.30233
188 1PZO CBT 9.87654
189 3V66 D3A 9.87654
190 5C2H 4PX 9.87654
191 2X5W K2B 9.87654
192 3C3N FMN 9.87654
193 5C2H 4XU 9.87654
194 5LOF 70R 9.87654
195 2R40 EPH 9.87654
196 4INW 1EY 9.87654
197 3HSS MLA 9.87654
198 6C7D EOJ 9.87654
199 2R40 20E 9.87654
200 4CRL C1I 9.87654
201 1G2N EPH 9.87654
202 2HHP FLC 10
203 1KPG 16A 10
204 3ETG GWD 10
205 4UDB CV7 10
206 5L7G 6QE 10
207 5MW4 5JU 10
208 5HCV 60R 10
209 4NKW PLO 10
210 5MWY YNU 10
211 1KPH 10A 10
212 5Y6Q MCN 10
213 2A3I C0R 10
214 2D5X L35 10
215 2QJY SMA 10
216 3E2M E2M 10
217 5FM0 WAQ 10
218 4JE7 BB2 10
219 5L7G LYS SER LEU LEU GLN GLN LEU LEU THR GLU 10
220 5DY5 5GR 11.1111
221 3ICT COA 11.1111
222 5M37 9SZ 11.1111
223 3ICS COA 11.1111
224 5TIV A3P 11.1111
225 2Y31 SMQ 11.1111
226 1N5S ADL 11.1111
227 2VBQ BSJ 11.1111
228 3MBG FAD 11.1111
229 3O55 FAD 11.1111
230 2HFK E4H 11.1111
231 5G57 6M5 11.1111
232 2BP1 FLC 11.1111
233 4RC8 STE 11.4286
234 2BJ4 OHT 11.4286
235 2QE4 JJ3 11.4286
236 3ET1 ET1 11.4286
237 3KDU NKS 11.4286
238 2X24 X24 11.4286
239 1K7L 544 11.4286
240 5AAV GW5 11.4286
241 4F7E 0SH 11.4286
242 4U0S ADP 11.4286
243 2VVT I24 11.4286
244 4H07 IPH 11.4286
245 4UCC ZKW 11.4286
246 1W96 S1A 11.4286
247 4E2J MOF 11.4286
248 5ECP JAA 11.4286
249 5ECP MET 11.4286
250 5ECP ATP 11.4286
251 5UFS 1TA 11.4286
252 2ZMF CMP 11.4286
253 4MGB XDH 11.4286
254 4F06 PHB 11.4286
255 1JR8 FAD 11.4286
256 2YPO PHE 11.4286
257 4MGA 27L 11.4286
258 4TV1 36M 11.4286
259 1IID NHM 11.4286
260 4H6Q TFB 11.4286
261 4TUZ 36J 11.4286
262 1FCH TYR GLN SER LYS LEU 11.4286
263 4Q9N NAI 11.4286
264 2NPA MMB 11.4286
265 4MGD 27N 11.4286
266 3EE4 MYR 12.3457
267 5CC2 CKA 12.3457
268 4OKZ 3E9 12.3457
269 2BIF BOG 12.3457
270 6F68 4EU 12.3457
271 3T58 FAD 12.3457
272 5XJ7 87O 12.3457
273 1HG4 LPP 12.3457
274 6FK3 PPI 12.3457
275 6F68 GSH 12.3457
276 2JG1 ANP 12.3457
277 5XJ8 NKO 12.3457
278 5CHR 4NC 12.3457
279 3SQP 3J8 12.3457
280 5DH3 5BS 12.3457
281 5BYK A3P 12.8571
282 5BYK OAQ 12.8571
283 1MHC FME TYR PHE ILE ASN ILE LEU THR LEU 12.8571
284 1FO0 ILE ASN PHE ASP PHE ASN THR ILE 12.8571
285 3JRX S1A 12.8571
286 1LEK GLU GLN TYR LYS PHE TYR SER VAL 12.8571
287 3SDV 911 12.8571
288 5T2Z 017 12.8571
289 5SYN 71T 12.8571
290 1M13 HYF 12.8571
291 5JFL NAD 12.8571
292 2E9L PLM 12.8571
293 2E9L BGC 12.8571
294 2E9L OLA 12.8571
295 2HZL PYR 12.8571
296 4MRP GSH 12.8571
297 6BVM EBV 13.5802
298 4URX FK1 13.5802
299 6D59 FVJ 13.5802
300 6D56 FVM 13.5802
301 6D5G FVD 13.5802
302 6D5H FV7 13.5802
303 1LN1 DLP 13.5802
304 1T0S BML 13.5802
305 6D55 FWA 13.5802
306 6BVJ EAS 13.5802
307 6BVL EBY 13.5802
308 6BVI EC4 13.5802
309 6BVK EAV 13.5802
310 2P1C GG3 13.5802
311 5LGA 6VH 14.2857
312 5NWI TYR PHE SER SEP ASN 14.2857
313 4I6G FAD 14.2857
314 1ZT1 PHE GLU ALA ASN GLY ASN LEU ILE 14.2857
315 1Y4Z PCI 14.2857
316 1NQ7 HIS LYS ILE LEU HIS ARG LEU LEU GLN GLU 14.2857
317 4WRI OKA 14.2857
318 4X8D AVI 14.2857
319 4OB6 S2T 14.2857
320 4Q0A GLY HIS LYS ILE LEU HIS ARG LEU LEU GLN 14.2857
321 3JRS A8S 14.2857
322 3GST GPR 14.2857
323 5LJ0 6XX 14.8148
324 3LN0 52B 14.8148
325 3RWP ABQ 14.8148
326 3AI3 SOE 14.8148
327 1R6N 434 14.8148
328 4KVL PLM 14.8148
329 1TFZ 869 14.8148
330 4C2X NHW 14.8148
331 5V13 JH3 14.8148
332 2O5L MNR 15.7143
333 4R38 RBF 15.7143
334 1QZR ANP 15.7143
335 2WCJ M21 15.7143
336 1IYK MYA 15.7143
337 3UVD MB3 15.7143
338 2IZ1 RES 15.7143
339 2C3Q GTX 15.7143
340 2O3Z AI7 15.7143
341 3NTD COA 16.0494
342 6CS8 F9Y 16.0494
343 2YNC YNC 16.0494
344 2FP2 TSA 16.0494
345 4EI7 GDP 16.0494
346 3EKK GS2 16.0494
347 3HRD MCN 16.0494
348 2ZCQ B65 17.1429
349 1RM6 PCD 17.1429
350 3D04 SAK 17.1429
351 3HP9 CF1 17.1429
352 2J4K U5P 17.1429
353 2ZKJ ADP 17.1429
354 3GZ9 D32 17.284
355 4PGK Y69 17.284
356 4O4Z N2O 17.284
357 3QCJ NX4 17.284
358 1Y7I SAL 17.284
359 1TZD ADP 17.284
360 2Y69 CHD 17.4603
361 1DKF BMS 18.5185
362 6F6E PLM 18.5185
363 4G31 0WH 18.5185
364 1DKF OLA 18.5185
365 4NAT ADP 18.5185
366 6A5Y 9CR 18.5185
367 6A5Y 9R0 18.5185
368 4NAT 2W5 18.5185
369 3FAL REA 18.5185
370 6BA2 7KM 18.5185
371 4POJ 2VP 18.5185
372 4M8E 29V 18.5185
373 3HB5 E2B 18.5185
374 2UXI G50 18.5714
375 2Q2Y MKR 18.5714
376 2Q2Y ADP 18.5714
377 1SR7 MOF 18.5714
378 3B9Z CO2 18.5714
379 1N20 3AG 18.5714
380 5CX6 CDP 18.5714
381 1UBY DMA 18.5714
382 4OAR 2S0 18.5714
383 5K7K 6RJ 18.5714
384 3STD MQ0 18.5714
385 5UQK U2F 18.5714
386 5Z1N PEF 18.5714
387 4IGH ORO 19.7531
388 4IGH 1EA 19.7531
389 4IGH FMN 19.7531
390 4OGQ 2WD 19.7531
391 4OGQ 7PH 19.7531
392 4OGQ 1O2 19.7531
393 4W97 UCA 19.7531
394 4OGQ 3WM 19.7531
395 5U98 1KX 20
396 6GH1 ARG LEU PRO ALA LYS ALA PRO LEU LEU 20
397 1OLM VTQ 20
398 5WL1 CUY 20
399 5ZKC 3C0 20
400 3WCA FPS 20
401 5WL1 D3D 20
402 6BJ3 ILE PRO LEU THR GLU GLU ALA GLU LEU 20
403 5T70 THR SER ASN LEU GLN GLU GLN ILE GLY TRP 20
404 3QFJ LEU LEU PHE GLY PHE PRO VAL TYR VAL 20
405 6C1R EFD 20
406 5C0C ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 20
407 1OGA GLY ILE LEU GLY PHE VAL PHE THR LEU 20
408 3QDJ ALA ALA GLY ILE GLY ILE LEU THR VAL 20
409 5ISZ GLY ILE LEU GLY PHE VAL PHE THR LEU 20
410 5JHD GLY ILE LEU GLY PHE VAL PHE THR LEU 20
411 5XS3 VAL ARG SER ARG ARG CYS LEU ARG LEU 20
412 3OV6 MK0 20
413 4X6F 3XU 20
414 5OLK DTP 20
415 2YCJ C2F 20.9877
416 5LU5 M7P 20.9877
417 2BCG GER 21.4286
418 5IKH 6BW 21.4286
419 5W7D PX8 21.4286
420 4YC9 4C1 21.4286
421 1KJM ALA GLN PHE SER ALA SER ALA SER ARG 21.4286
422 1BC5 SAH 21.4286
423 5OCA 9QZ 22.2222
424 1T27 PCW 22.2222
425 6D6L FY4 22.2222
426 5WP5 SAH 22.2222
427 2HFP NSI 22.8571
428 3B1M KRC 22.8571
429 3G9E RO7 22.8571
430 3FUR Z12 22.8571
431 1AUA BOG 22.8571
432 1FM9 570 22.8571
433 1RDT 570 22.8571
434 3H0A D30 22.8571
435 5N69 2OW 22.8571
436 1I0B PEL 22.8571
437 3KRO DST 22.8571
438 3KRO IPE 22.8571
439 1FM9 9CR 22.8571
440 3WDM ADN 22.8571
441 5TWO 7MV 22.8571
442 5WP4 SAH 22.8571
443 2DYR PGV 23.4043
444 2DYR TGL 23.4043
445 5ZCO TGL 23.4043
446 5Z84 PSC 23.4043
447 2DYS TGL 23.4043
448 5ZCO PEK 23.4043
449 5W97 CHD 23.4043
450 5Z84 PGV 23.4043
451 5Z84 TGL 23.4043
452 5ZCO PGV 23.4043
453 2DYS PGV 23.4043
454 5Z84 CHD 23.4043
455 2DYR PEK 23.4043
456 2DYS PEK 23.4043
457 5ZCO CHD 23.4043
458 5ZCO PSC 23.4043
459 3CXH SMA 23.4568
460 5MBC FMN 23.4568
461 6BQC LOP 23.4568
462 5XJD 87L 23.4568
463 1EZV SMA 23.4568
464 3G08 FEE 24.2857
465 3QUZ QUV 24.2857
466 3RUG DB6 24.2857
467 3SCM LGN 24.2857
468 3QKD HI0 24.2857
469 5LIA 6XN 24.2857
470 1HK8 DGT 24.2857
471 3TDC 0EU 24.2857
472 5Y02 HBX 24.2857
473 4XCP PLM 24.2857
474 2YOO K2B 24.2857
475 5Y02 MXN 24.2857
476 1DEK DGP 24.2857
477 2PV7 NAD 24.2857
478 5B0I BOG 24.2857
479 6CAY ERG 24.6914
480 3GWT 066 24.6914
481 1XMU ROF 24.6914
482 1XMY ROL 24.6914
483 5OHJ 9VE 24.6914
484 5HCN DAO 24.6914
485 4DR9 BB2 24.6914
486 1XM4 PIL 24.6914
487 4LPG 1MV 25.7143
488 3RDE OYP 25.7143
489 2WYA HMG 25.7143
490 1N1G BCP 25.7143
491 1T3Q MCN 25.7143
492 1JQ9 PHE LEU SER TYR LYS 25.7143
493 4Q86 AMP 25.9259
494 3G4G D71 25.9259
495 1XON PIL 25.9259
496 5K52 OCD 25.9259
497 2VL8 UDP 25.9259
498 3G58 988 25.9259
499 2VL8 CTS 25.9259
500 4ZAL 4LR 25.9259
501 4ZAL FNR 25.9259
502 2VAT COA 25.9259
503 1LOX RS7 27.1429
504 1OUK 084 27.1429
505 4LY9 S6P 27.1429
506 4LY9 1YY 27.1429
507 2WME NAP 27.1429
508 5K53 STE 27.1605
509 4XVX P33 FDA 27.1605
510 2WPB ZZI 28.3951
511 5W7B MYR 28.5714
512 3ET3 ET1 28.5714
513 2P4Y C03 28.5714
514 3LDW ZOL 30
515 3CGD FAD 30
516 3CGD NAD 30
517 3CGD COA 30
518 4ELG 52I 30
519 3LDW IPE 30
520 1UHK CZN 30
521 4ELG 52J 30
522 2OI9 GLN LEU SER PRO PHE PRO PHE ASP LEU 31.4286
523 1BII ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 31.4286
524 5IVX ARG GLY PRO GLY ARG ALA PHE VAL THR ILE 31.4286
525 2XSU PIE 32.0988
526 1RQJ RIS 32.0988
527 4WZ8 3W7 32.8571
528 2BVL UDP 32.8571
529 2BVL GLC 32.8571
530 5N5U 7N8 35.7143
531 2Z3U CRR 35.7143
532 1D5Z ACE ALC ARG ALA ODA SER LEU NH2 37.1429
533 3QCP FAD 38.5714
534 3KPX CZH 38.5714
535 4Z87 GDP 39.5062
536 3IQE F42 42.8571
537 3GN8 DEX 47.619
538 1M2Z DEX 47.619
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