Receptor
PDB id Resolution Class Description Source Keywords
5T46 1.53 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF THE HUMAN EIF4E-EIF4G COMPLEX HOMO SAPIENS TRANSLATION GENE REGULATION CAP BINDING PROTEIN 4E-BINDINPROTEIN TRANSLATION INITIATION EIF4F
Ref.: THE STRUCTURES OF EIF4E-EIF4G COMPLEXES REVEAL AN E INTERFACE TO REGULATE TRANSLATION INITIATION. MOL.CELL V. 64 467 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL C:304;
C:305;
C:303;
C:306;
C:302;
A:303;
A:302;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
MGP C:301;
A:301;
Valid;
Valid;
none;
none;
submit data
538.215 C11 H19 N5 O14 P3 C[n+]...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5T46 1.53 Å NON-ENZYME: TRANSCRIPT_TRANSLATE CRYSTAL STRUCTURE OF THE HUMAN EIF4E-EIF4G COMPLEX HOMO SAPIENS TRANSLATION GENE REGULATION CAP BINDING PROTEIN 4E-BINDINPROTEIN TRANSLATION INITIATION EIF4F
Ref.: THE STRUCTURES OF EIF4E-EIF4G COMPLEXES REVEAL AN E INTERFACE TO REGULATE TRANSLATION INITIATION. MOL.CELL V. 64 467 2016
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 309 families.
1 5T46 - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 263 families.
1 5T46 - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 221 families.
1 5T46 - MGP C11 H19 N5 O14 P3 C[n+]1cn(c....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: MGP; Similar ligands found: 82
No: Ligand ECFP6 Tc MDL keys Tc
1 MGP 1 1
2 6G0 0.986667 1
3 G7M 0.794872 0.987013
4 GTG 0.741935 0.974684
5 GTA 0.71875 0.974684
6 MG7 0.653846 0.884615
7 MGO 0.619565 0.901235
8 GTP 0.619565 0.961039
9 GDP 7MG 0.592233 0.949367
10 GP3 0.55914 0.936709
11 GDP 0.553191 0.961039
12 GSP 0.525253 0.91358
13 MGQ 0.514852 0.925
14 GAV 0.5 0.925
15 GNH 0.5 0.948718
16 MGV 0.5 0.880952
17 G1R 0.5 0.948718
18 01G 0.495327 0.870588
19 9GM 0.49505 0.936709
20 GNP 0.49505 0.936709
21 JSQ 0.494845 0.841463
22 HFD 0.494845 0.841463
23 HEJ 0.494737 0.884615
24 ATP 0.494737 0.884615
25 5FA 0.489583 0.884615
26 AQP 0.489583 0.884615
27 GCP 0.485149 0.936709
28 G5P 0.477477 0.936709
29 7DT 0.474227 0.871795
30 G2R 0.471698 0.925
31 5GP 0.46875 0.948052
32 ITT 0.46875 0.835443
33 G 0.46875 0.948052
34 G3A 0.468468 0.936709
35 0O2 0.46729 0.948052
36 AJQ 0.466102 0.926829
37 GDC 0.463636 0.925
38 GDD 0.463636 0.925
39 GKE 0.463636 0.925
40 Y9Z 0.463636 0.892857
41 GMV 0.460784 0.936709
42 GDR 0.459459 0.949367
43 GFB 0.459459 0.949367
44 DGT 0.456311 0.888889
45 GPD 0.45614 0.914634
46 6CK 0.455357 0.902439
47 G2P 0.451923 0.925
48 B4P 0.447917 0.860759
49 AP5 0.447917 0.860759
50 JB2 0.447368 0.949367
51 GKD 0.447368 0.925
52 8GT 0.445545 0.843373
53 NGD 0.445378 0.949367
54 GPG 0.440367 0.925
55 BA3 0.4375 0.860759
56 GH3 0.433962 0.935897
57 ADP 0.43299 0.884615
58 6YZ 0.432692 0.8625
59 GP2 0.431373 0.925
60 GDX 0.431034 0.936709
61 MGT 0.428571 0.837209
62 YGP 0.428571 0.891566
63 RGT 0.428571 0.875
64 IDP 0.425743 0.935065
65 JB3 0.425 0.9375
66 A4P 0.425 0.83908
67 CAG 0.424 0.894118
68 25L 0.423423 0.873418
69 A2D 0.416667 0.860759
70 7DD 0.414141 0.871795
71 6AD 0.413462 0.855422
72 SAP 0.411765 0.841463
73 AGS 0.411765 0.841463
74 G3D 0.411215 0.948052
75 G2Q 0.409091 0.925
76 ALF 5GP 0.40566 0.879518
77 TPG 0.40458 0.853933
78 ACQ 0.403846 0.8625
79 ANP 0.403846 0.8625
80 G4P 0.40367 0.948052
81 C1Z 0.401786 0.948052
82 2MD 0.4 0.860465
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5T46; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5t46.bio2) has 10 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5T46; Ligand: MGP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 5t46.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
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