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Receptor
PDB id Resolution Class Description Source Keywords
5T9F 1.99 Å EC: 1.3.1.13 PREPHENATE DEHYDROGENASE N222D MUTANT FROM SOYBEAN GLYCINE MAX DEHYDROGENASE TYROSINE BIOSYNTHESIS OXIDOREDUCTASE
Ref.: MOLECULAR BASIS OF THE EVOLUTION OF ALTERNATIVE TYR BIOSYNTHETIC ROUTES IN PLANTS. NAT. CHEM. BIOL. V. 13 1029 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
TYR B:302;
A:302;
 Valid;
Valid;
 none;
none;
 ic50 = 4.7 mM
181.189 C9 H11 N O3 c1cc(...
NAP A:301;
B:301;
 Valid;
Valid;
 none;
none;
 submit data
743.405 C21 H28 N7 O17 P3 c1cc(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5T9F 1.99 Å EC: 1.3.1.13 PREPHENATE DEHYDROGENASE N222D MUTANT FROM SOYBEAN GLYCINE MAX DEHYDROGENASE TYROSINE BIOSYNTHESIS OXIDOREDUCTASE
Ref.: MOLECULAR BASIS OF THE EVOLUTION OF ALTERNATIVE TYR BIOSYNTHETIC ROUTES IN PLANTS. NAT. CHEM. BIOL. V. 13 1029 2017
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 5WHX - CIT C6 H8 O7 C(C(=O)O)C....
2 5T95 ic50 = 5.9 mM TYR C9 H11 N O3 c1cc(ccc1C....
3 5T9F ic50 = 4.7 mM TYR C9 H11 N O3 c1cc(ccc1C....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 5WHX - CIT C6 H8 O7 C(C(=O)O)C....
2 5T95 ic50 = 5.9 mM TYR C9 H11 N O3 c1cc(ccc1C....
3 5T9F ic50 = 4.7 mM TYR C9 H11 N O3 c1cc(ccc1C....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 5WHX - CIT C6 H8 O7 C(C(=O)O)C....
2 5T95 ic50 = 5.9 mM TYR C9 H11 N O3 c1cc(ccc1C....
3 5T9F ic50 = 4.7 mM TYR C9 H11 N O3 c1cc(ccc1C....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: TYR; Similar ligands found: 30
No: Ligand ECFP6 Tc MDL keys Tc
1 TYR 1 1
2 DTY 1 1
3 TYC 0.694444 0.78125
4 PFF 0.657895 0.741935
5 4BF 0.615385 0.741935
6 PHI 0.615385 0.741935
7 TFQ 0.595238 0.666667
8 0A1 0.585366 0.9
9 7N8 0.585366 0.666667
10 4AF 0.585366 0.827586
11 4CF 0.571429 0.733333
12 PHE 0.564103 0.814815
13 DPN 0.564103 0.814815
14 34H 0.564103 0.666667
15 PBF 0.531915 0.8
16 PTR 0.521739 0.675
17 AEG 0.513514 0.689655
18 DAH 0.5 0.84375
19 3NF 0.478261 0.764706
20 TYE 0.475 0.8
21 IYR 0.468085 0.818182
22 YOF 0.468085 0.818182
23 4HP 0.447368 0.642857
24 2LT 0.444444 0.794118
25 485 0.442623 0.613636
26 E42 0.433962 0.9
27 33S 0.416667 0.741935
28 HPP 0.414634 0.655172
29 NAL 0.411765 0.766667
30 AZY 0.4 0.658537
Ligand no: 2; Ligand: NAP; Similar ligands found: 123
No: Ligand ECFP6 Tc MDL keys Tc
1 NAP 1 1
2 NA0 0.881356 0.986301
3 TAP 0.872881 0.934211
4 NDO 0.840336 0.972603
5 NAD 0.811966 0.986111
6 N01 0.733871 0.958904
7 A3D 0.712 0.972603
8 NBP 0.707692 0.935065
9 NHD 0.68254 0.958904
10 NJP 0.661417 0.972973
11 NFD 0.658915 0.934211
12 NXX 0.619048 0.959459
13 DND 0.619048 0.959459
14 AMP NAD 0.606061 0.958904
15 ZID 0.605839 0.972603
16 NAQ 0.59854 0.922078
17 ATR 0.59292 0.917808
18 NAE 0.591241 0.946667
19 NDE 0.58042 0.986301
20 A22 0.571429 0.958904
21 NAJ 0.567164 0.986111
22 A2R 0.563025 0.932432
23 NDC 0.561644 0.922078
24 NA7 0.552846 0.907895
25 ODP 0.551471 0.935065
26 A2P 0.539823 0.930556
27 8ID 0.537313 0.910256
28 NPW 0.525547 0.8875
29 NZQ 0.521739 0.910256
30 CNA 0.521739 0.959459
31 NDP 0.514493 0.922078
32 PO4 PO4 A A A A PO4 0.503937 0.930556
33 1DG 0.503401 0.922078
34 DG1 0.503401 0.922078
35 TXP 0.5 0.922078
36 NMN AMP PO4 0.492958 0.921053
37 XNP 0.492958 0.875
38 25L 0.492308 0.958904
39 25A 0.492063 0.972222
40 NMN 0.486726 0.888889
41 NGD 0.485714 0.935065
42 9JJ 0.481707 0.8875
43 2AM 0.477876 0.891892
44 ADP 0.458333 0.945205
45 PAP 0.451613 0.931507
46 A2D 0.445378 0.945205
47 AN2 0.442623 0.932432
48 7L1 0.441558 0.777778
49 ADP PO3 0.44 0.944444
50 SAP 0.44 0.896104
51 AGS 0.44 0.896104
52 M33 0.439024 0.906667
53 AR6 AR6 0.438849 0.945205
54 BA3 0.438017 0.945205
55 OAD 0.43609 0.92
56 ADP BMA 0.43609 0.92
57 DQV 0.435714 0.958904
58 HEJ 0.435484 0.945205
59 ATP 0.435484 0.945205
60 OOB 0.435115 0.958904
61 B4P 0.434426 0.945205
62 AP5 0.434426 0.945205
63 GAP 0.433071 0.92
64 0WD 0.432432 0.922078
65 2A5 0.432 0.87013
66 5FA 0.432 0.945205
67 AQP 0.432 0.945205
68 AT4 0.430894 0.907895
69 00A 0.428571 0.909091
70 DAL AMP 0.427481 0.932432
71 CA0 0.427419 0.92
72 ADP ALF 0.426357 0.871795
73 ALF ADP 0.426357 0.871795
74 9X8 0.425373 0.871795
75 ACP 0.424 0.92
76 NAJ PZO 0.423841 0.897436
77 9SN 0.423358 0.897436
78 ADP VO4 0.423077 0.932432
79 VO4 ADP 0.423077 0.932432
80 WAQ 0.422222 0.884615
81 V3L 0.421875 0.945205
82 ACQ 0.421875 0.92
83 ADQ 0.421053 0.92
84 AR6 0.420635 0.918919
85 APR 0.420635 0.918919
86 ATP A A A 0.42029 0.958333
87 CO7 0.419753 0.786517
88 3OD 0.419118 0.92
89 1ZZ 0.419118 0.841463
90 DLL 0.41791 0.958904
91 AD9 0.417323 0.92
92 NAX 0.416667 0.875
93 OVE 0.416667 0.857143
94 MYR AMP 0.416058 0.841463
95 AV2 0.415385 0.868421
96 A3P 0.414634 0.944444
97 NNR 0.414414 0.72973
98 OMR 0.413793 0.831325
99 6YZ 0.412214 0.92
100 ANP 0.410853 0.92
101 A1R 0.410448 0.860759
102 ABM 0.409836 0.893333
103 A 0.408333 0.944444
104 AMP 0.408333 0.944444
105 SON 0.408 0.933333
106 PPS 0.407692 0.829268
107 5AL 0.407692 0.932432
108 NAI 0.406897 0.909091
109 7D3 0.406504 0.857143
110 ADX 0.404762 0.829268
111 ATF 0.40458 0.907895
112 3UK 0.404412 0.945946
113 TYR AMP 0.404255 0.921053
114 AMP DBH 0.404255 0.894737
115 139 0.402685 0.875
116 50T 0.401575 0.906667
117 SRP 0.401515 0.907895
118 A A 0.40146 0.972222
119 B5V 0.40146 0.933333
120 A3R 0.4 0.860759
121 3AM 0.4 0.90411
122 B5M 0.4 0.921053
123 FA5 0.4 0.933333
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5T9F; Ligand: NAP; Similar sites found with APoc: 715
This union binding pocket(no: 1) in the query (biounit: 5t9f.bio2) has 38 residues
No: Leader PDB Ligand Sequence Similarity
1 2WD7 NAP None
2 1VL8 NAP None
3 1H5Q NAP None
4 4USI AKG None
5 3HGM ATP None
6 5O3Q CMP None
7 2VZ0 NAP None
8 2VZ0 D64 None
9 2AG5 NAD None
10 2BOS GLA GAL GLC None
11 2BOS GLA GAL GLC NBU None
12 2W47 UNF None
13 2DT5 NAD 1.10701
14 1LUA NAP 1.10701
15 4E5N NAD 1.47601
16 5IN4 GDP 1.47601
17 5IN4 6CK 1.47601
18 5IN4 NAP 1.47601
19 2I6U CP 1.47601
20 2CVQ NDP 1.47601
21 1XG5 NAP 1.47601
22 4OSP NAP 1.52091
23 1O5I NAD 1.60643
24 2EWM NAD 1.60643
25 2BD0 NAP 1.63934
26 3NOJ PYR 1.68067
27 4ZO3 C6L 1.70068
28 3GFB NAD 1.84502
29 1O0S NAI 1.84502
30 1D1T NAD 1.84502
31 1HDG NAD 1.84502
32 1DRV A3D 1.84502
33 1XF1 CIT 1.84502
34 1E3I CXF 1.84502
35 1ZH8 NAP 1.84502
36 3VYW SAM 1.84502
37 3U4C NDP 1.84502
38 3WXB NDP 1.84502
39 4ITU 1HS 1.85874
40 4ITU NAI 1.85874
41 3RFV 15L 1.87266
42 3RFV NAI 1.87266
43 1E3W NAD 1.91571
44 1U7T NAD 1.91571
45 1U7T TDT 1.91571
46 1E6W NAD 1.92308
47 1UZN NAP 2.02429
48 3LN9 FLC 2.15827
49 1NXJ TLA 2.18579
50 5L4S NAP 2.20126
51 5L4S 6KX 2.20126
52 2CVZ NDP 2.21402
53 1NVT NAP 2.21402
54 3KB6 NAD 2.21402
55 1LDM NAD 2.21402
56 1VL0 NAI 2.21402
57 1UXG FUM 2.21402
58 1UXG NAD 2.21402
59 1F8F NAD 2.21402
60 1YS4 NAP 2.21402
61 5KKA 6V0 2.21402
62 2FZW NAD 2.21402
63 3KO8 NAD 2.21402
64 2JHF NAD 2.21402
65 1U3U BNF 2.21402
66 1U3U NAD 2.21402
67 1X7D ORN 2.21402
68 6A0S NDP 2.21402
69 6A0S HSE 2.21402
70 1TB4 PEJ 2.21402
71 4XB2 HSE 2.21402
72 4ZVV NAD 2.21402
73 3ZV6 4HB 2.21402
74 3ZV6 NAD 2.21402
75 4XZ3 COA 2.21402
76 4ZVV GN0 2.21402
77 1X7D NAD 2.21402
78 4XB2 NDP 2.21402
79 1EK6 NAI 2.21402
80 1GZ6 NAI 2.21402
81 6BWL NAD 2.21402
82 1EK6 UPG 2.21402
83 4EUE NAI 2.21402
84 1V59 NAD 2.21402
85 5HV7 RBL 2.21402
86 2B4Q NAP 2.21402
87 4K5S FAD 2.21402
88 3JQ7 NAP 2.21402
89 1ZBQ NAD 2.21402
90 3QWI CUE 2.22222
91 3QWI NAP 2.22222
92 5D4V SAH 2.23881
93 2EV9 NAP 2.28137
94 2EV9 SKM 2.28137
95 5G6U TRP 2.29885
96 1GEG NAD 2.34375
97 3ICC NAP 2.35294
98 1F9A ATP 2.38095
99 4CJX NAP 2.50784
100 1V6A TRE 2.58303
101 6C4M NAP 2.58303
102 4Y9D NAI 2.58303
103 1OMO NAD 2.58303
104 3A06 NDP 2.58303
105 9LDT NAD 2.58303
106 1F8G NAD 2.58303
107 5W3K NDP 2.58303
108 5W3K 9TY 2.58303
109 1N7G GDR 2.58303
110 1CDO NAD 2.58303
111 2V5K OXM 2.58303
112 4XDY NAI 2.58303
113 5DN9 NAD 2.58303
114 1WVG APR 2.58303
115 4RQU NAD 2.58303
116 4J1Q NDP 2.58303
117 1LDN NAD 2.58303
118 1N7G NDP 2.58303
119 6C4N NAP 2.58303
120 5ZI2 ADP 2.58303
121 1BDB NAD 2.58303
122 5ZEC NAP 2.58303
123 5ZI2 NAD 2.58303
124 5Y77 FAD 2.58303
125 5TOW ADN 2.58303
126 5TOW NAI 2.58303
127 9LDB NAD 2.58303
128 5THQ NDP 2.58303
129 1VKO NAD 2.58303
130 5ZXD ATP 2.58303
131 1SAY PYR 2.58303
132 1ML4 PAL 2.58303
133 4O1M NAD 2.58303
134 3A06 FOM 2.58303
135 1I0B PEL 2.58303
136 1X87 NAD 2.58303
137 1BXK NAD 2.58303
138 1NFQ NAI 2.69231
139 3A28 NAD 2.71318
140 4B5W PYR 2.73438
141 3ORF NAD 2.78884
142 3CYQ AMU 2.89855
143 4NBT NAD 2.91667
144 1KYQ NAD 2.95203
145 3ICS ADP 2.95203
146 3ICT ADP 2.95203
147 2HJR APR 2.95203
148 2D2I NAP 2.95203
149 1WP4 NDP 2.95203
150 3OND NAD 2.95203
151 3OND ADN 2.95203
152 5LD5 NAD 2.95203
153 4YCA NDP 2.95203
154 2NAD NAD 2.95203
155 3C1O NAP 2.95203
156 5E4R NAP 2.95203
157 1OC2 TDX 2.95203
158 1OC2 NAD 2.95203
159 3L4S NAD 2.95203
160 4GKV NAD 2.95203
161 5AHO TLA 2.95203
162 3L4S 3PG 2.95203
163 1RM0 D6P 2.95203
164 1W6U NAP 2.95203
165 1RM0 NAI 2.95203
166 1W73 NAP 2.95203
167 1W8D NAP 2.95203
168 1LLU NAD 2.95203
169 1SOW NAD 2.95203
170 5O42 9JW 2.95203
171 5O42 BGC 2.95203
172 5O42 NAD 2.95203
173 1Z45 NAD 2.95203
174 1RYD NDP 2.95203
175 4XDZ NDP 2.95203
176 2QZZ EMF 2.95203
177 4DPL NAP 2.95203
178 1PZG A3D 2.95203
179 1H6C NDP 2.95203
180 2QZZ NAP 2.95203
181 4EDF UPG 2.95203
182 1H6C SIN 2.95203
183 2NVK NAP 2.95203
184 5FEU NAP 2.95203
185 6DNT NAD 2.95203
186 5D63 FUC GLA GLA 2.95203
187 5NMX NAP 2.95203
188 5E5U MLI 3.01508
189 5EPO NAP 3.05344
190 2J83 BAT 3.05344
191 5FFF NAP 3.11284
192 3SJ7 NDP 3.1746
193 1C3V NDP 3.26531
194 2BKA NDP 3.30579
195 1P77 ATR 3.32103
196 1QMG APX 3.32103
197 1DLJ UGA 3.32103
198 1DLJ NAI 3.32103
199 1LC3 NAD 3.32103
200 2BGM NAJ 3.32103
201 4JJF FE9 3.32103
202 1RM4 NDP 3.32103
203 1UWK NAD 3.32103
204 1UWK URO 3.32103
205 1H2B NAJ 3.32103
206 4E13 NAD 3.32103
207 1Y1P NMN AMP PO4 3.32103
208 1WMA NDP 3.32103
209 1WMA AB3 3.32103
210 2I3G NAP 3.32103
211 4TSK NDP 3.32103
212 4PVD NDP 3.32103
213 5OVL NAP 3.32103
214 6F9Q NAD 3.32103
215 3HB5 NAP 3.32103
216 3WLE NAD 3.32103
217 4XYB NDP 3.32103
218 5B4T NAD 3.32103
219 5B4T 3HR 3.32103
220 3LU1 NAD 3.32103
221 5GSN NAP 3.32103
222 1I2B USQ 3.32103
223 1I2B NAD 3.32103
224 1I2B UPG 3.32103
225 2YY7 NAD 3.32103
226 1KOL NAD 3.32103
227 4HXY NDP 3.32103
228 3O26 NDP 3.32103
229 5L4L NAP 3.32103
230 5VRH PLM 3.32103
231 5F5N NAD 3.32103
232 4JJF N2I 3.32103
233 1E5Q NDP 3.32103
234 4YAG NAI 3.32103
235 3Q3C NAD 3.34448
236 1ZEM NAD 3.43511
237 3UWV 2PG 3.44828
238 4JK3 NAD 3.4749
239 4NBW NAD 3.50195
240 5OVK NDP 3.51562
241 4FN4 NAD 3.54331
242 1YQD NAP 3.55191
243 2Q46 NAP 3.55731
244 1J5P NAD 3.55731
245 5FI3 NAP 3.64146
246 2JAP NDP 3.64372
247 2JAH NDP 3.64372
248 2G5C NAD 3.69004
249 6F3N ADN 3.69004
250 6F3N NAD 3.69004
251 1GV0 NAD 3.69004
252 6F3M NAD 3.69004
253 5L53 NAP 3.69004
254 5Z21 NAI 3.69004
255 5CAE SIN 3.69004
256 2B4R AES 3.69004
257 1KEV NDP 3.69004
258 2B4R NAD 3.69004
259 1AE1 NAP 3.69004
260 6CEP OXM 3.69004
261 2YVJ NAI 3.69004
262 6CEP NAD 3.69004
263 1HKU NAD 3.69004
264 1GUZ NAD 3.69004
265 6HKE MLT 3.69004
266 5CAE COA 3.69004
267 1SC6 NAD 3.69004
268 6HKE LMR 3.69004
269 1RKX NAD 3.69004
270 6EGU 43Y 3.69004
271 1B8U NAD 3.69004
272 1OBB NAD 3.69004
273 1OF8 G3P 3.69004
274 3V1U NAD 3.69004
275 4AU8 Z3R 3.69004
276 1LTH NAD 3.69004
277 1DIG NAP 3.69004
278 3TY3 GGG 3.69004
279 2YVF FAD 3.69004
280 2YVF NAD 3.69004
281 1N5D NDP 3.69004
282 2GV8 NDP 3.69004
283 3W68 4PT 3.7594
284 2Q2V NAD 3.92157
285 3SJU NDP 3.94265
286 2FDW D3G 3.9916
287 3BAZ NAP 4.05904
288 1KJ8 GAR 4.05904
289 2CDU ADP 4.05904
290 2O4C NAD 4.05904
291 4B4U NAP 4.05904
292 2A92 NAI 4.05904
293 5MQ6 NDP 4.05904
294 3VPH NAD 4.05904
295 5MSO NAP 4.05904
296 1G0N PHH 4.05904
297 1G0N NDP 4.05904
298 1KEW TYD 4.05904
299 1KEW NAD 4.05904
300 1J49 NAD 4.05904
301 1V8B NAD 4.05904
302 6AA8 NAD 4.05904
303 5N6C NAD 4.05904
304 1C1X NAD 4.05904
305 4L8V NAP 4.05904
306 3VPH OXM 4.05904
307 5O98 NAP 4.05904
308 4ZRN UPG 4.05904
309 6CI9 NAP 4.05904
310 2FR1 NDP 4.05904
311 1JA9 NDP 4.05904
312 4PIV NDP 4.05904
313 1BW9 NAD 4.05904
314 3H5N ATP 4.05904
315 1T26 NAI 4.05904
316 1T26 GBD 4.05904
317 1YKF NAP 4.05904
318 1BXG NAD 4.05904
319 4ZRN NAD 4.05904
320 5JCM ISD 4.05904
321 5JCM FAD 4.05904
322 5JCM NAD 4.05904
323 3I6I NDP 4.05904
324 5AX9 4KT 4.05904
325 1XHL NDP 4.05904
326 2ZKJ ADP 4.05904
327 1C3M MAN MAN 4.08163
328 3AY6 NAI 4.08922
329 3AY6 BGC 4.08922
330 5NM7 GLY 4.13534
331 2AG8 NAP 4.18251
332 2DKN NAI 4.31373
333 2ZJ1 NAD 4.42804
334 1LJ8 NAD 4.42804
335 2ZJ1 ARJ 4.42804
336 5X20 NAD 4.42804
337 1M2W NAD 4.42804
338 1EZ4 NAD 4.42804
339 5U5N NAD 4.42804
340 5X9D 80F 4.42804
341 5K4W THR 4.42804
342 1ZQ9 SAM 4.42804
343 5K4W NAI 4.42804
344 4OM8 NAD 4.42804
345 4MP8 MLI 4.42804
346 4MP8 NAD 4.42804
347 5GWT NAD 4.42804
348 4PLT NAI 4.42804
349 3WBF NAP 4.42804
350 3WBF API 4.42804
351 4PLT OXM 4.42804
352 5Z2L NDP 4.42804
353 2B5W NAP 4.42804
354 2GZ3 NAP 4.42804
355 3O9Z AKG 4.42804
356 3O9Z NAD 4.42804
357 5GWT SIN 4.42804
358 4C3Y FAD 4.42804
359 1Y8Q ATP 4.42804
360 4D42 NAP 4.42804
361 4D42 W0I 4.42804
362 5T2U NAP 4.43548
363 2VOH CIT 4.4586
364 1FWV SGA MAG FUC 4.47761
365 2DTX BMA 4.54545
366 3WV8 ATP 4.58716
367 4J4H NAI 4.6332
368 4J4H 1J1 4.6332
369 1MUU NAD 4.79705
370 5M67 3D1 4.79705
371 5M67 ADE 4.79705
372 5M67 NAD 4.79705
373 1Z82 NDP 4.79705
374 1O6Z NAD 4.79705
375 3CIF NAD 4.79705
376 3S5W NAP 4.79705
377 3ULK NDP 4.79705
378 1EQ2 ADQ 4.79705
379 5O9F 9ON 4.79705
380 5O9F NAD 4.79705
381 2C29 NAP 4.79705
382 3UOY FAD 4.79705
383 3UOY NAP 4.79705
384 1UDB NAD 4.79705
385 1UDB UFG 4.79705
386 4G5H UD7 4.79705
387 4G5H NAP 4.79705
388 1J0X NAD 4.79705
389 4GNI ATP 4.79705
390 3OJO NAD 4.79705
391 5YAP NAI 4.79705
392 5U8U FAD 4.79705
393 2C29 DQH 4.79705
394 1EQ2 NAP 4.79705
395 5GUD NDP 4.79705
396 5OD2 GLC 4.79705
397 5X68 FAD 4.79705
398 2XVE FAD 4.79705
399 5YAP 8S0 4.79705
400 3CIF G3H 4.79705
401 1IY8 NAD 4.86891
402 1R37 NAD 4.89914
403 1PR9 NAP 4.91803
404 3D3W NAP 4.91803
405 5A1T OXM 4.98534
406 5A1T NAI 4.98534
407 5YSS NAD 5.07812
408 2VT3 ATP 5.11628
409 2WSB NAD 5.11811
410 1A5Z NAD 5.16605
411 3H8V ATP 5.16605
412 1GZ4 ATP 5.16605
413 1MV8 NAD 5.16605
414 5XQL C2E 5.16605
415 4YT4 FE9 5.16605
416 5A04 BGC 5.16605
417 5A04 NDP 5.16605
418 1WPQ NAD 5.16605
419 1NYT NAP 5.16605
420 3VZS NAP 5.16605
421 5NUF NAD 5.16605
422 1PL6 572 5.16605
423 4J7U NAP 5.16605
424 4J7U YTZ 5.16605
425 5KVS NAP 5.16605
426 5YU3 PRO 5.16605
427 5YU3 NAD 5.16605
428 1PL6 NAD 5.16605
429 1Z6Z NAP 5.16605
430 5NUE NAD 5.16605
431 2FYF PLP 5.16605
432 1ONX ASP 5.16605
433 4OPC PGT 5.16605
434 3VZS CAA 5.16605
435 4W6Z 8ID 5.16605
436 4OPC FDA 5.16605
437 1PGP 6PG 5.16605
438 4RF2 NAP 5.16605
439 3ETG NDP 5.16605
440 3ETG GLU 5.16605
441 2CFC NAD 5.2
442 1I36 NAP 5.30303
443 3RKR NAP 5.34351
444 1CER NAD 5.53506
445 3V1Y NAD 5.53506
446 1GAD NAD 5.53506
447 2GSD NAD 5.53506
448 3WMX NAD 5.53506
449 2VHW NAI 5.53506
450 3CMC NAD 5.53506
451 4U7W NDP 5.53506
452 1EBF NAD 5.53506
453 5O0J GLC 5.53506
454 3ITJ CIT 5.53506
455 1PS9 NAP 5.53506
456 1K3T BRZ 5.53506
457 4AP3 FAD 5.53506
458 4AP3 NAP 5.53506
459 2RAB NAD 5.53506
460 2QRK AMP 5.53506
461 3T3Z 9PL 5.53506
462 5A96 GTP 5.62249
463 4URF NAD 5.64516
464 3KLJ FAD 5.71429
465 2OOR NAD 5.74713
466 4CQM NAP 5.74713
467 2AE2 PTO 5.76923
468 2AE2 NAP 5.76923
469 1OAA OAA 5.79151
470 1YJQ NAP 5.90406
471 4KQW NAP 5.90406
472 4R5M NAP 5.90406
473 1HYE NAP 5.90406
474 2NU8 COA 5.90406
475 4R1S NAP 5.90406
476 4R5M 4NO 5.90406
477 1GQ2 NAP 5.90406
478 5UR0 NAD 5.90406
479 1SB8 UD2 5.90406
480 4M3P HCS 5.90406
481 2JL1 NAP 5.90406
482 3L6C MLI 5.90406
483 1SB8 NAD 5.90406
484 3AFN NAP 5.90406
485 4UP4 GAL NAG 5.90406
486 2DBZ NAP 5.98802
487 5N2I NAP 6.03448
488 4II2 ATP 6.13497
489 4O0L NDP 6.18182
490 5OCM NAP 6.27306
491 5UAV NDP 6.27306
492 5UAV TFB 6.27306
493 4KOA NDP 6.27306
494 1DSS NAD 6.27306
495 4Z0H NAD 6.27306
496 2IZ1 ATR 6.27306
497 1DJN ADP 6.27306
498 3THR C2F 6.27306
499 2YYY NAP 6.27306
500 4OOE FOM 6.27306
501 4OOE NDP 6.27306
502 6A3J SOE 6.27306
503 1P0F NAP 6.27306
504 6ER9 FAD 6.27306
505 4PLG OXM 6.27306
506 4PLG NAI 6.27306
507 5VN0 NAI 6.27306
508 6A3J NAI 6.27306
509 1RPN NDP 6.27306
510 2Y6Q FAD 6.27306
511 6ER9 NAP 6.27306
512 1Q19 SSC 6.27306
513 1XCL SAH 6.38298
514 3NUG NAD 6.47773
515 2ZAT NAP 6.53846
516 2GL0 ADN 6.58683
517 2DFV NAD 6.64207
518 5Z75 NAD 6.64207
519 3JQG NAP 6.64207
520 4CM8 NAP 6.64207
521 3JQA NAP 6.64207
522 3BMQ NAP 6.64207
523 3BMO NAP 6.64207
524 4CM4 NAP 6.64207
525 3CH6 NAP 6.64207
526 3CH6 311 6.64207
527 1XSE NDP 6.64207
528 3JQF NAP 6.64207
529 5JDI NAP 6.64207
530 4CMI NAP 6.64207
531 4CLR NAP 6.64207
532 3JQB NAP 6.64207
533 3JQ9 NAP 6.64207
534 5JCJ NAP 6.64207
535 5JDC NAP 6.64207
536 3T31 DCQ 6.64207
537 3T31 FAD 6.64207
538 1GY8 NAD 6.64207
539 4K26 NDP 6.64207
540 5K6A NAP 6.64207
541 3BMN NAP 6.64207
542 3UCL NAP 6.64207
543 4CM9 NAP 6.64207
544 5Y1G AKB 6.64207
545 5Y1G NAD 6.64207
546 3JQ8 NAP 6.64207
547 4FC7 COA 6.64207
548 4FC7 NAP 6.64207
549 4CLO NAP 6.64207
550 4CME NAP 6.64207
551 1UP7 NAD 6.64207
552 4K26 SFF 6.64207
553 4QED NAP 6.85484
554 1FK8 NAD 7.00389
555 4JBI NDP 7.01107
556 1E7S NAP 7.01107
557 2VYN NAD 7.01107
558 1YKJ FAD 7.01107
559 1YKJ PHB 7.01107
560 4Q9N NAI 7.01107
561 3WGT FAD 7.01107
562 1U1I NAD 7.14286
563 1NPD NAD 7.38007
564 1VI2 NAD 7.38007
565 3FWN ATR 7.38007
566 5KMS NAD 7.38007
567 2C5A GDC 7.38007
568 2C5A NAD 7.38007
569 3EJW PAV 7.38007
570 1VM6 NAD 7.45614
571 5Z2F NAP 7.54717
572 5GT9 NAP 7.60456
573 1PJS NAD 7.74908
574 5BSH PRO 7.74908
575 3A4V NAD 7.74908
576 3A4V PYR 7.74908
577 3H9E NAD 7.74908
578 5BJX NAD 7.74908
579 2GN4 UD1 7.74908
580 2GN4 NDP 7.74908
581 5MDH NAD 7.74908
582 5BJX UDP 7.74908
583 4MDH NAD 7.74908
584 4GLL NAD 7.74908
585 4ZA2 NAD 7.90514
586 5JE8 NAD 8.11808
587 2IXB A2G 8.11808
588 2IXB NAD 8.11808
589 2GLX NDP 8.11808
590 4TQG NDP 8.11808
591 1H82 GZZ 8.11808
592 3OID NDP 8.11808
593 1ORR NAD 8.11808
594 1H82 FAD 8.11808
595 4D3F NAP 8.48709
596 6BII NAP 8.48709
597 4UP3 NDP 8.48709
598 5H81 NAP 8.48709
599 1X14 NAD 8.48709
600 3L9W GSH 8.48709
601 1NVM NAD 8.48709
602 3O03 NAP 8.48709
603 1FGX U5P 8.48709
604 1XKQ NDP 8.48709
605 3L9W AMP 8.48709
606 5WQP NAP 8.54701
607 5WQP NCA 8.54701
608 2VWT PYR 8.61423
609 2AHR NAP 8.85609
610 5G4L NDP 8.85609
611 3GEG NAD 8.90688
612 4NBU NAI 9.2
613 3NJ4 AFX 9.22509
614 3NJ4 NAD 9.22509
615 2PK3 A2R 9.22509
616 3B20 NAD 9.22509
617 4XQC 13D 9.22509
618 4XQC NAD 9.22509
619 1WDK NAD 9.22509
620 5XWV NDP 9.22509
621 5XWV 8H6 9.22509
622 2QTZ FAD 9.22509
623 5AOV NAP 9.22619
624 1MJH ATP 9.25926
625 1Q7B NAP 9.42623
626 3K5I AIR 9.5941
627 1R6D NAD 9.5941
628 1R6D DAU 9.5941
629 2F2U M77 9.5941
630 5WUW NAP 9.5941
631 3H4V NAP 9.5941
632 2GDZ NAD 9.5941
633 3GD4 NAD 9.5941
634 4D79 ATP 9.9631
635 4RDH AMP 9.9631
636 4RDI ATP 9.9631
637 1N1G BCP 9.9631
638 1Q0H NDP 9.9631
639 1Q0H FOM 9.9631
640 5ZZ6 ADP 10.0962
641 4IF4 BEF 10.0962
642 5ZZ6 NAD 10.0962
643 1GR0 NAD 10.3321
644 5OJL TXP 10.4027
645 1O94 ADP 10.6061
646 1O94 AMP 10.6061
647 4KVL PLM 10.7011
648 6C4T NA7 10.7011
649 4YAC NAI 10.7011
650 2GCG NDP 10.7011
651 2CDC XYP 10.7011
652 2CDC XYS 10.7011
653 2CDC NAP 10.7011
654 5YEC ATP 10.9244
655 3HAD NAD 11.0701
656 3DAG FEG 11.0701
657 5ZI9 FLC 11.1538
658 2HK9 NAP 11.4391
659 2RH4 EMO 11.4391
660 1F06 2NP 11.4391
661 1F06 NDP 11.4391
662 1C0I FAD 11.4391
663 1C0I BE2 11.4391
664 5CG1 NAD BBN 11.4391
665 2HK9 ATR 11.4391
666 5VKT NAP 11.6022
667 3TN7 NJP 11.6732
668 5J5Z FAD 11.8081
669 5OOH NAP 12.1359
670 5OOH 9ZZ 12.1359
671 5EES NAP 12.1457
672 5U5G NAP 12.1771
673 1CF2 NAP 12.1771
674 3OA2 NAD 12.1771
675 1JAY NAP 12.2642
676 4D04 NAP 12.5461
677 4D04 FAD 12.5461
678 1GEE NAD 12.6437
679 5GZ6 NDP 12.9151
680 5GZ6 7C3 12.9151
681 2Q0L NAP 12.9151
682 5KHD C2E 13.1868
683 4KP7 NAP 13.2841
684 3WQQ NDP 13.2841
685 3WQQ IB3 13.2841
686 4BVA T3 13.2841
687 4BVA NDP 13.2841
688 4KP7 1UQ 13.2841
689 3QV1 NAD 13.4146
690 5Z20 NAI 13.6531
691 1HYH NAD 13.6531
692 2DC1 NAD 13.9831
693 4ZGS NAD 14.0221
694 3RJ5 NAD 14.5669
695 1EDO NAP 14.7541
696 5Y8L HUI 14.7601
697 5Y8L NAD 14.7601
698 2PRG BRL 14.7727
699 2RI1 GLP 14.8936
700 5XVH NAP 15.4982
701 3ABI NAD 15.8672
702 3GGO ENO 16.6052
703 3GGO NAI 16.6052
704 3TWO NDP 16.6052
705 4TM3 FAD 18.0812
706 5AYV KPL 18.4466
707 5AYV NAP 18.4466
708 5EIN NAP 20.3704
709 1LSS NAD 22.8571
710 2HMT NAI 23.6111
711 2PV7 NAD 25.8303
712 3B1F NAD 28.7823
713 2F1K NAP 29.5203
714 5L95 AMP 38.75
715 3B1J NAD 40
Pocket No.: 2; Query (leader) PDB : 5T9F; Ligand: TYR; Similar sites found with APoc: 738
This union binding pocket(no: 2) in the query (biounit: 5t9f.bio2) has 39 residues
No: Leader PDB Ligand Sequence Similarity
1 2WD7 NAP None
2 1VL8 NAP None
3 2BOS GLA GAL GLC NBU None
4 1H5Q NAP None
5 4USI AKG None
6 2AG5 NAD None
7 3HGM ATP None
8 2VZ0 D64 None
9 2VZ0 NAP None
10 1LUA NAP 1.10701
11 2DT5 NAD 1.10701
12 4E5N NAD 1.47601
13 5IN4 GDP 1.47601
14 5IN4 6CK 1.47601
15 5IN4 NAP 1.47601
16 2CVQ NDP 1.47601
17 2I6U CP 1.47601
18 1XG5 NAP 1.47601
19 4OSP NAP 1.52091
20 1O5I NAD 1.60643
21 2EWM NAD 1.60643
22 2BD0 NAP 1.63934
23 3NOJ PYR 1.68067
24 4ZO3 C6L 1.70068
25 3GFB NAD 1.84502
26 1O0S NAI 1.84502
27 1D1T NAD 1.84502
28 1HDG NAD 1.84502
29 1DRV A3D 1.84502
30 1E3I CXF 1.84502
31 1XF1 CIT 1.84502
32 1ZH8 NAP 1.84502
33 3VYW SAM 1.84502
34 3U4C NDP 1.84502
35 3WXB NDP 1.84502
36 2Q1S NAI 1.84502
37 4ITU 1HS 1.85874
38 4ITU NAI 1.85874
39 3RFV 15L 1.87266
40 3RFV NAI 1.87266
41 1E3W NAD 1.91571
42 1U7T NAD 1.91571
43 1U7T TDT 1.91571
44 1E6W NAD 1.92308
45 1UZN NAP 2.02429
46 3LN9 FLC 2.15827
47 1NXJ TLA 2.18579
48 5L4S 6KX 2.20126
49 5L4S NAP 2.20126
50 2CVZ NDP 2.21402
51 1NVT NAP 2.21402
52 1LDM NAD 2.21402
53 1VL0 NAI 2.21402
54 1UXG NAD 2.21402
55 1UXG FUM 2.21402
56 1F8F NAD 2.21402
57 3KB6 NAD 2.21402
58 1YS4 NAP 2.21402
59 5KKA 6V0 2.21402
60 2JHF NAD 2.21402
61 3KO8 NAD 2.21402
62 2FZW NAD 2.21402
63 1U3U BNF 2.21402
64 1U3U NAD 2.21402
65 6A0S HSE 2.21402
66 6A0S NDP 2.21402
67 4XB2 HSE 2.21402
68 1X7D ORN 2.21402
69 1TB4 PEJ 2.21402
70 4ZVV NAD 2.21402
71 3ZV6 4HB 2.21402
72 3ZV6 NAD 2.21402
73 4XZ3 COA 2.21402
74 4ZVV GN0 2.21402
75 1EK6 NAI 2.21402
76 1X7D NAD 2.21402
77 1V59 NAD 2.21402
78 6BWL NAD 2.21402
79 2B4Q NAP 2.21402
80 1EK6 UPG 2.21402
81 4EUE NAI 2.21402
82 1GZ6 NAI 2.21402
83 3BRE C2E 2.21402
84 3JQ7 NAP 2.21402
85 4XB2 NDP 2.21402
86 4K5S FAD 2.21402
87 1ZBQ NAD 2.21402
88 3QWI CUE 2.22222
89 3QWI NAP 2.22222
90 5D4V SAH 2.23881
91 1SNY NAP 2.24719
92 2EV9 NAP 2.28137
93 2EV9 SKM 2.28137
94 4KWI NAP 2.28137
95 4KWI 1TJ 2.28137
96 1GEG NAD 2.34375
97 3ICC NAP 2.35294
98 4CJX NAP 2.50784
99 1V6A TRE 2.58303
100 4Y9D NAI 2.58303
101 6C4M NAP 2.58303
102 1F8G NAD 2.58303
103 1OMO NAD 2.58303
104 9LDT NAD 2.58303
105 3A06 NDP 2.58303
106 1CDO NAD 2.58303
107 5W3K NDP 2.58303
108 5W3K 9TY 2.58303
109 2V5K OXM 2.58303
110 1N7G GDR 2.58303
111 1BXK NAD 2.58303
112 1WVG APR 2.58303
113 4XDY NAI 2.58303
114 4J1Q NDP 2.58303
115 5DN9 NAD 2.58303
116 4RQU NAD 2.58303
117 5ZEC NAP 2.58303
118 1LDN NAD 2.58303
119 1BDB NAD 2.58303
120 1N7G NDP 2.58303
121 2J5V PCA 2.58303
122 5Y77 FAD 2.58303
123 5ZI2 ADP 2.58303
124 6C4N NAP 2.58303
125 5ZI2 NAD 2.58303
126 5THQ NDP 2.58303
127 9LDB NAD 2.58303
128 5TOW NAI 2.58303
129 5TOW ADN 2.58303
130 1VKO NAD 2.58303
131 4O1M NAD 2.58303
132 1SAY PYR 2.58303
133 1ML4 PAL 2.58303
134 1LDN FBP 2.58303
135 3A06 FOM 2.58303
136 5ZXD ATP 2.58303
137 1X87 NAD 2.58303
138 1VJT NAD 2.58303
139 1NFQ NAI 2.69231
140 3A28 NAD 2.71318
141 4B5W PYR 2.73438
142 3ORF NAD 2.78884
143 1UAY ADN 2.89256
144 3CYQ AMU 2.89855
145 4NBT NAD 2.91667
146 1KYQ NAD 2.95203
147 3ICS ADP 2.95203
148 2HJR APR 2.95203
149 3ICT ADP 2.95203
150 2D2I NAP 2.95203
151 5LD5 NAD 2.95203
152 1WP4 NDP 2.95203
153 3OND NAD 2.95203
154 3OND ADN 2.95203
155 4YCA NDP 2.95203
156 3L4S NAD 2.95203
157 2NAD NAD 2.95203
158 3C1O NAP 2.95203
159 3L4S 3PG 2.95203
160 5AHO TLA 2.95203
161 1RM0 D6P 2.95203
162 5E4R NAP 2.95203
163 4GKV NAD 2.95203
164 1OC2 TDX 2.95203
165 1OC2 NAD 2.95203
166 1W6U NAP 2.95203
167 1W8D NAP 2.95203
168 1SOW NAD 2.95203
169 5O42 BGC 2.95203
170 5O42 NAD 2.95203
171 5O42 9JW 2.95203
172 1W73 NAP 2.95203
173 1RM0 NAI 2.95203
174 1LLU NAD 2.95203
175 1Z45 NAD 2.95203
176 1RYD NDP 2.95203
177 4DPL NAP 2.95203
178 1PZG A3D 2.95203
179 2NVK NAP 2.95203
180 5FEU NAP 2.95203
181 1H6C NDP 2.95203
182 4EDF UPG 2.95203
183 4XDZ NDP 2.95203
184 1H6C SIN 2.95203
185 6DNT NAD 2.95203
186 2QZZ EMF 2.95203
187 2QZZ NAP 2.95203
188 5NMX NAP 2.95203
189 6EL3 NAP 2.95203
190 5E5U MLI 3.01508
191 5EPO NAP 3.05344
192 2J83 BAT 3.05344
193 5FFF NAP 3.11284
194 6A46 DCM 3.125
195 3SJ7 NDP 3.1746
196 1C3V NDP 3.26531
197 2BKA NDP 3.30579
198 1P77 ATR 3.32103
199 1QMG APX 3.32103
200 1DLJ UGA 3.32103
201 1DLJ NAI 3.32103
202 1LC3 NAD 3.32103
203 2BGM NAJ 3.32103
204 1RM4 NDP 3.32103
205 1Y1P NMN AMP PO4 3.32103
206 4JJF FE9 3.32103
207 1H2B NAJ 3.32103
208 1UWK URO 3.32103
209 1UWK NAD 3.32103
210 4E13 NAD 3.32103
211 4JJF N2I 3.32103
212 3LU1 NAD 3.32103
213 1WMA AB3 3.32103
214 1WMA NDP 3.32103
215 4PVD NDP 3.32103
216 5OVL NAP 3.32103
217 6F9Q NAD 3.32103
218 2I3G NAP 3.32103
219 3WLE NAD 3.32103
220 3TTN SPD 3.32103
221 2YY7 NAD 3.32103
222 5GSN NAP 3.32103
223 3HB5 NAP 3.32103
224 4TSK NDP 3.32103
225 5L4L NAP 3.32103
226 5B4T 3HR 3.32103
227 5B4T NAD 3.32103
228 4XYB NDP 3.32103
229 1I2B UPG 3.32103
230 1I2B NAD 3.32103
231 1I2B USQ 3.32103
232 3O26 NDP 3.32103
233 4HXY NDP 3.32103
234 1KOL NAD 3.32103
235 4YAG NAI 3.32103
236 1A27 NAP 3.32103
237 1E5Q NDP 3.32103
238 4UBT 3G6 3.32103
239 1U8X NAD 3.32103
240 5F5N NAD 3.32103
241 3Q3C NAD 3.34448
242 3BPX SAL 3.37838
243 1ZEM NAD 3.43511
244 2XOC ADE 3.44828
245 4JK3 NAD 3.4749
246 4NBW NAD 3.50195
247 5OVK NDP 3.51562
248 2BO4 FLC 3.52645
249 4FN4 NAD 3.54331
250 1YQD NAP 3.55191
251 2Q46 NAP 3.55731
252 1J5P NAD 3.55731
253 5FI3 NAP 3.64146
254 2JAP NDP 3.64372
255 2JAH NDP 3.64372
256 2G5C NAD 3.69004
257 6F3N ADN 3.69004
258 6F3N NAD 3.69004
259 1GV0 NAD 3.69004
260 6F3M NAD 3.69004
261 5L53 NAP 3.69004
262 2B4R AES 3.69004
263 5Z21 NAI 3.69004
264 2B4R NAD 3.69004
265 1AE1 NAP 3.69004
266 2YVJ NAI 3.69004
267 6CEP OXM 3.69004
268 6CEP NAD 3.69004
269 6HKE MLT 3.69004
270 5CAE SIN 3.69004
271 1KEV NDP 3.69004
272 3V1U NAD 3.69004
273 1HKU NAD 3.69004
274 1GUZ NAD 3.69004
275 1O5Q PYR 3.69004
276 1B8U NAD 3.69004
277 1SC6 NAD 3.69004
278 1RKX NAD 3.69004
279 5CAE COA 3.69004
280 1OBB NAD 3.69004
281 1ZGS XMM 3.69004
282 4AU8 Z3R 3.69004
283 1LTH NAD 3.69004
284 1N5D NDP 3.69004
285 2GV8 NDP 3.69004
286 1DIG NAP 3.69004
287 2GVC FAD 3.69004
288 2YVF NAD 3.69004
289 2YVF FAD 3.69004
290 1VQW FAD 3.69004
291 6EGU 43Y 3.69004
292 1RL4 BRR 3.7234
293 3W68 4PT 3.7594
294 2Q2V NAD 3.92157
295 3SJU NDP 3.94265
296 3BAZ NAP 4.05904
297 1KJ8 GAR 4.05904
298 2CDU ADP 4.05904
299 5MSO NAP 4.05904
300 2O4C NAD 4.05904
301 2A92 NAI 4.05904
302 5MQ6 NDP 4.05904
303 1G0N PHH 4.05904
304 1G0N NDP 4.05904
305 4B4U NAP 4.05904
306 1KEW NAD 4.05904
307 1KEW TYD