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Receptor
PDB id Resolution Class Description Source Keywords
5TUK 1.85 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF TETRACYCLINE DESTRUCTASE TET(51) UNCULTURED BACTERIUM FAD-BINDING TETRACYCLINE-INACTIVATING OXIDOREDUCTASE ACTIVOXIDOREDUCTASE
Ref.: PLASTICITY, DYNAMICS, AND INHIBITION OF EMERGING TETRACYCLINE RESISTANCE ENZYMES. NAT. CHEM. BIOL. V. 13 730 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL D:401;
A:401;
B:401;
C:401;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
FAD B:402;
A:402;
D:402;
C:402;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
785.55 C27 H33 N9 O15 P2 Cc1cc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5TUK 1.85 Å EC: 2.-.-.- CRYSTAL STRUCTURE OF TETRACYCLINE DESTRUCTASE TET(51) UNCULTURED BACTERIUM FAD-BINDING TETRACYCLINE-INACTIVATING OXIDOREDUCTASE ACTIVOXIDOREDUCTASE
Ref.: PLASTICITY, DYNAMICS, AND INHIBITION OF EMERGING TETRACYCLINE RESISTANCE ENZYMES. NAT. CHEM. BIOL. V. 13 730 2017
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 269 families.
1 5TUK - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 237 families.
1 5TUF ic50 = 83.2 uM TDC C22 H22 N2 O7 Cc1c2cccc(....
2 5TUI - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
3 5TUE - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
4 5TUK - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 187 families.
1 5TUF ic50 = 83.2 uM TDC C22 H22 N2 O7 Cc1c2cccc(....
2 5TUI - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
3 5TUE - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
4 5TUK - FAD C27 H33 N9 O15 P2 Cc1cc2c(cc....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: FAD; Similar ligands found: 128
No: Ligand ECFP6 Tc MDL keys Tc
1 FAD 1 1
2 FAS 1 1
3 FAY 0.859259 0.9875
4 RFL 0.852941 0.963855
5 6FA 0.794118 0.987654
6 FAE 0.751773 0.987654
7 SFD 0.651007 0.860215
8 FDA 0.641892 0.906977
9 FNK 0.602564 0.876405
10 62F 0.572327 0.939024
11 F2N 0.566265 0.886364
12 FMN 0.543307 0.876543
13 FA9 0.526316 0.939759
14 6YU 0.516304 0.860215
15 P6G FDA 0.511628 0.908046
16 FAD NBT 0.508876 0.83871
17 A2D 0.504065 0.875
18 P5F 0.491329 0.941176
19 FAD CNX 0.488506 0.8125
20 AR6 0.488372 0.851852
21 APR 0.488372 0.851852
22 AGS 0.484615 0.811765
23 SAP 0.484615 0.811765
24 M33 0.484375 0.864198
25 BA3 0.484127 0.875
26 HEJ 0.48062 0.851852
27 ATP 0.48062 0.851852
28 ADP 0.480315 0.851852
29 B4P 0.480315 0.875
30 AP5 0.480315 0.875
31 ANP 0.477273 0.831325
32 AQP 0.476923 0.851852
33 5FA 0.476923 0.851852
34 48N 0.469388 0.902439
35 OAD 0.467626 0.876543
36 9X8 0.467626 0.833333
37 FAD NBA 0.467033 0.793814
38 GTA 0.465753 0.892857
39 AN2 0.465116 0.841463
40 AT4 0.465116 0.821429
41 AD9 0.462121 0.831325
42 3OD 0.460993 0.876543
43 RBF 0.460938 0.790123
44 FB0 0.460606 0.835165
45 139 0.460526 0.858824
46 AP0 0.46 0.835294
47 A22 0.459854 0.864198
48 ACP 0.458015 0.853659
49 8QN 0.456522 0.864198
50 PRX 0.454545 0.831325
51 A3R 0.453237 0.86747
52 A1R 0.453237 0.86747
53 G3A 0.452055 0.902439
54 T5A 0.45098 0.872093
55 G5P 0.44898 0.902439
56 ATF 0.448529 0.821429
57 50T 0.44697 0.819277
58 6YZ 0.445255 0.853659
59 ACQ 0.444444 0.853659
60 CNV FAD 0.443182 0.917647
61 ADQ 0.442857 0.853659
62 PAJ 0.442857 0.847059
63 5AL 0.441176 0.864198
64 ADX 0.439394 0.775281
65 CA0 0.439394 0.853659
66 A4P 0.437909 0.831461
67 25L 0.4375 0.864198
68 P33 FDA 0.436464 0.817204
69 5SV 0.435714 0.793103
70 OMR 0.434211 0.818182
71 TXE 0.434211 0.890244
72 ABM 0.434109 0.829268
73 A 0.433071 0.82716
74 AMP 0.433071 0.82716
75 4AD 0.432624 0.855422
76 ADJ 0.432258 0.818182
77 B5M 0.431507 0.878049
78 B5Y 0.431507 0.878049
79 BIS 0.430556 0.802326
80 SRA 0.429688 0.788235
81 AFH 0.42953 0.825581
82 NXX 0.427632 0.865854
83 DND 0.427632 0.865854
84 UP5 0.427632 0.878049
85 6V0 0.427632 0.857143
86 TXD 0.427632 0.890244
87 DQV 0.426667 0.8875
88 SRP 0.42446 0.843373
89 PR8 0.423611 0.837209
90 T99 0.423358 0.821429
91 TAT 0.423358 0.821429
92 AMO 0.422535 0.865854
93 TXA 0.42069 0.865854
94 FYA 0.42069 0.864198
95 PTJ 0.42069 0.835294
96 CNA 0.420382 0.865854
97 00A 0.41958 0.823529
98 AHX 0.41958 0.835294
99 MAP 0.41844 0.811765
100 NAI 0.418301 0.845238
101 AU1 0.41791 0.831325
102 A12 0.416667 0.843373
103 AP2 0.416667 0.843373
104 25A 0.415493 0.851852
105 9ZA 0.415493 0.845238
106 9ZD 0.415493 0.845238
107 COD 0.415094 0.842697
108 4TC 0.412903 0.879518
109 APC 0.411765 0.843373
110 ME8 0.410959 0.806818
111 1ZZ 0.410959 0.806818
112 NB8 0.410959 0.835294
113 4UW 0.409091 0.825581
114 NAX 0.409091 0.837209
115 F2R 0.408805 0.850575
116 RBY 0.408759 0.843373
117 ADV 0.408759 0.843373
118 P1H 0.405882 0.818182
119 OOB 0.405594 0.864198
120 LAD 0.40411 0.825581
121 A A 0.40411 0.829268
122 UPA 0.403846 0.86747
123 4UU 0.401316 0.833333
124 GA7 0.401316 0.865854
125 A3D 0.401235 0.876543
126 80F 0.401235 0.808989
127 XAH 0.4 0.806818
128 DLL 0.4 0.864198
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5TUK; Ligand: FAD; Similar sites found with APoc: 736
This union binding pocket(no: 1) in the query (biounit: 5tuk.bio3) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 2DT5 NAD 0.947867
2 4YT4 FE9 1.06667
3 1YS4 NAP 1.12994
4 1KEV NDP 1.4245
5 2AQJ FAD 1.47059
6 2AQJ TRP 1.47059
7 3CGB FAD 1.47059
8 5GSN FAD 1.47059
9 5GSN NAP 1.47059
10 5GSN MMZ 1.47059
11 1X87 NAD 1.47059
12 2NZ2 ASP 1.47059
13 5AHO TLA 1.4881
14 1J0X NAD 1.50602
15 1CER NAD 1.51057
16 2O4C NAD 1.57895
17 1E3I CXF 1.59574
18 4RQU NAD 1.6
19 2GZ3 NAP 1.63934
20 1H2B NAJ 1.67131
21 5LD5 NAD 1.67598
22 2B5W NAP 1.68067
23 1BXK NAD 1.69014
24 4YKG NAD 1.71569
25 4YKG FAD 1.71569
26 5UAO FAD 1.71569
27 5O9F 9ON 1.71569
28 5O9F NAD 1.71569
29 1VKO NAD 1.71569
30 6E1Q CFA 1.71569
31 6GNA FAD 1.73611
32 1LUA NAP 1.74216
33 5YU3 NAD 1.74419
34 5YU3 PRO 1.74419
35 4Z0H NAD 1.79641
36 1LTH NAD 1.88088
37 4ZRN UPG 1.92308
38 4ZRN NAD 1.92308
39 5YF1 SFG 1.9337
40 3AYI FAD 1.96078
41 3AYI HCI 1.96078
42 1VJT NAD 1.96078
43 3Q9T FAY 1.96078
44 5GUD NDP 1.96078
45 5GUD 2IT 1.96078
46 5TOW NAI 1.9656
47 5TOW ADN 1.9656
48 5Z20 NAI 2.02899
49 2QRK AMP 2.03046
50 5Y8L NAD 2.0339
51 1R6D NAD 2.07715
52 1R6D DAU 2.07715
53 1RYI GOA 2.09424
54 1RYI FAD 2.09424
55 1ZQ9 SAM 2.10526
56 4E5N NAD 2.12121
57 3QPB R1P 2.12766
58 4MO2 FAD 2.17391
59 4MO2 FDA 2.17391
60 1XHC FAD 2.17984
61 3W6X HZP 2.18341
62 1KYQ NAD 2.18978
63 2V6G NAP 2.1978
64 3GD4 FAD 2.20588
65 1KNR FAD 2.20588
66 3GD4 NAD 2.20588
67 4BV6 FAD 2.20588
68 2WET FAD 2.20588
69 2CDU FAD 2.20588
70 1DJN ADP 2.20588
71 4MOP 2H5 2.20588
72 5OC1 FAD 2.20588
73 3UCL NAP 2.20588
74 6H3O FAD 2.20588
75 3UCL FAD 2.20588
76 3UCL CYH 2.20588
77 2JB2 PHE 2.20588
78 2JB2 FAD 2.20588
79 2CDU ADP 2.20588
80 2ZJ1 NAD 2.20588
81 2ZJ1 ARJ 2.20588
82 1RM0 NAI 2.20588
83 1RM0 D6P 2.20588
84 2JHP SAH 2.20588
85 5MLR NAP 2.20588
86 5MLR GRQ 2.20588
87 1PJS NAD 2.20588
88 1K3T BRZ 2.22841
89 4UP4 NDG 2.24439
90 3DXY SAM 2.29358
91 4JJF FE9 2.32558
92 4ZCC NAI 2.38095
93 4ZCC FAD 2.38095
94 2VHW NAI 2.38727
95 5OCM NAP 2.4055
96 2JHF NAD 2.40642
97 5G48 1FL 2.40642
98 1D1T NAD 2.41287
99 1PZG A3D 2.41692
100 1GAD NAD 2.42424
101 5EYY MDM 2.44898
102 1OFL ASG GCD 2.45098
103 4B63 FAD 2.45098
104 4B63 NAP 2.45098
105 4B63 ORN 2.45098
106 3X0V FAD 2.45098
107 5VN0 NAI 2.45098
108 5EB4 FAD 2.45098
109 5VN0 FAD 2.45098
110 6F97 FAD 2.45098
111 1GZ4 ATP 2.45098
112 1V8B NAD 2.45098
113 2QGI UDP 2.45098
114 1T9D P22 2.45098
115 2IYF UDP 2.45098
116 5YAP NAI 2.45098
117 5YAP 8S0 2.45098
118 2I7C AAT 2.4735
119 5UAV NDP 2.48447
120 5UAV TFB 2.48447
121 3DAG FEG 2.51397
122 1EBF NAD 2.51397
123 4CNK FAD 2.55754
124 1X7D ORN 2.57143
125 1X7D NAD 2.57143
126 1P77 ATR 2.57353
127 1GV0 NAD 2.58065
128 1GUZ NAD 2.58065
129 5NII FAD 2.589
130 1WDI CIT 2.6087
131 4M37 SAH 2.62391
132 5NM7 GLY 2.63158
133 4NTD FAD 2.64706
134 3B1J NAD 2.65487
135 3B20 NAD 2.65487
136 3OND ADN 2.66393
137 3OND NAD 2.66393
138 4GKV NAD 2.67857
139 5OJL TXP 2.68456
140 3FPF TNA 2.68456
141 3FPF MTA 2.68456
142 5F1V 3VN 2.6936
143 6CEP OXM 2.69461
144 6CEP NAD 2.69461
145 4MDH NAD 2.69461
146 1E1M FAD 2.69608
147 1E1M NAP 2.69608
148 3ICS FAD 2.69608
149 3ICR FAD 2.69608
150 3ICT FAD 2.69608
151 5MBX FAD 2.69608
152 5MBX SP5 2.69608
153 2R4J 13P 2.69608
154 2R4J FAD 2.69608
155 3ICT ADP 2.69608
156 3ICS ADP 2.69608
157 3L9W AMP 2.69608
158 3QVP FAD 2.69608
159 1P9B HDA 2.69608
160 3L9W GSH 2.69608
161 4ZVV GN0 2.71084
162 4ZVV NAD 2.71084
163 9LDB NAD 2.71084
164 9LDT NAD 2.71084
165 1LDM NAD 2.73556
166 1SOW NAD 2.7439
167 1WP4 NDP 2.76817
168 2CVZ NDP 2.76817
169 5A96 GTP 2.81124
170 3H5N ATP 2.83286
171 5TC4 NAD 2.8481
172 1OC2 NAD 2.87356
173 1OC2 TDX 2.87356
174 4EMI NAD 2.92683
175 4EMI FAD 2.92683
176 1GPE FAD 2.94118
177 1GQ2 NAP 2.94118
178 1ZGS XMM 2.94118
179 4XZ3 COA 2.94118
180 5X62 SAH 2.94118
181 4XYM COA 2.94118
182 5X9D 80F 2.96053
183 1N1G BCP 3.00546
184 4GNC ASO 3.01003
185 5N2I NAP 3.01724
186 5D63 FUC GLA GLA 3.07167
187 5ZHO A2G GLA FUC 3.08642
188 1OMO NAD 3.10559
189 1F8G NAD 3.125
190 6HL7 CP 3.16092
191 1J5P NAD 3.16206
192 1D4D FAD 3.18627
193 2RAB NAD 3.18627
194 2RAB FAD 3.18627
195 3CGD FAD 3.18627
196 3CGD COA 3.18627
197 3CGD NAD 3.18627
198 2HQM FAD 3.18627
199 1COY AND 3.18627
200 1COY FAD 3.18627
201 3K7M FAD 3.18627
202 5TTJ FAD 3.18627
203 5HSA FAS 3.18627
204 6F7L FAD 3.18627
205 5U5G NAP 3.18627
206 4EDF UPG 3.18627
207 2Q0L NAP 3.21543
208 2Q0L FAD 3.21543
209 1P0F NAP 3.21716
210 3K5I AIR 3.22581
211 1DLJ NAI 3.23383
212 1DLJ UGA 3.23383
213 1RJW ETF 3.24484
214 5BSH PRO 3.2491
215 5BJX UDP 3.27869
216 5BJX NAD 3.27869
217 5O4J 9KH 3.28467
218 5O4J PJL 3.28467
219 5O4J SAH 3.28467
220 1YKJ PHB 3.29949
221 1YKJ FAD 3.29949
222 1HDG NAD 3.31325
223 3AB1 FAD 3.33333
224 2GTF P1R 3.33333
225 1HKU NAD 3.35196
226 5D4V SAH 3.35821
227 3KLJ FAD 3.37662
228 5WGR FAD 3.43137
229 4AP3 NAP 3.43137
230 4AP3 FAD 3.43137
231 3GDN HBX 3.43137
232 3GDN FAD 3.43137
233 5G3U FDA 3.43137
234 5G3U ITW 3.43137
235 3LAD FAD 3.43137
236 1MUU NAD 3.43137
237 1Q9I FAD 3.43137
238 1Q9I TEO 3.43137
239 1MV8 NAD 3.43137
240 6C4T NA7 3.43137
241 3ETG GLU 3.43137
242 3ETG NDP 3.43137
243 3ETG GTP 3.43137
244 6C4M NAP 3.43137
245 4RLQ 3SK 3.43137
246 5ZI2 NAD 3.47826
247 5CAE COA 3.51438
248 6F5W KG1 3.52304
249 3O9Z AKG 3.52564
250 3O9Z NAD 3.52564
251 2BOI MFU 3.53982
252 5JCM ISD 3.54767
253 5JCM NAD 3.54767
254 5JCM FAD 3.54767
255 2CDC XYP 3.55191
256 2CDC XYS 3.55191
257 2CDC NAP 3.55191
258 1UXG FUM 3.55987
259 1UXG NAD 3.55987
260 1RM4 NDP 3.56083
261 5NUE NAD 3.61446
262 5NUF NAD 3.61446
263 4ZGS NAD 3.62694
264 1YJQ NAP 3.63036
265 1ZK7 FAD 3.64026
266 1B8U NAD 3.64742
267 5N6C NAD 3.66667
268 4TXI FAD 3.67647
269 4M52 M52 3.67647
270 4M52 FAD 3.67647
271 2A8X FAD 3.67647
272 1MO9 KPC 3.67647
273 1MO9 FAD 3.67647
274 2BRY FAD 3.67647
275 1NAA ABL 3.67647
276 1NAA 6FA 3.67647
277 2YVF FAD 3.67647
278 2YVF NAD 3.67647
279 2YVJ FAD 3.67647
280 5NA1 FAD 3.67647
281 2YVJ NAI 3.67647
282 1PS9 FAD 3.67647
283 4Z24 FAD 3.67647
284 1PS9 NAP 3.67647
285 1Y8Q ATP 3.67647
286 5GZ6 7C3 3.68098
287 5GZ6 NDP 3.68098
288 3FG2 FAD 3.71287
289 5UR0 NAD 3.72493
290 1CDO NAD 3.74332
291 1U3U NAD 3.74332
292 1U3U BNF 3.74332
293 3ZNN FAD 3.7464
294 3ZNN 4WL 3.7464
295 3WGT FAD 3.7464
296 3WGT QSC 3.7464
297 1O94 ADP 3.75
298 3V1Y NAD 3.85757
299 1SAY PYR 3.87812
300 5EJ2 NAD 3.8961
301 1DSS NAD 3.9039
302 2DKH FAD 3.92157
303 2DKH 3HB 3.92157
304 1Q1R FAD 3.92157
305 4IV9 FAD 3.92157
306 3NJ4 NAD 3.92157
307 3NJ4 AFX 3.92157
308 1UP7 NAD 3.92157
309 4HA6 FAD 3.93701
310 5FJN FAD 3.94737
311 5FJN BE2 3.94737
312 1O6Z NAD 3.9604
313 5JE8 NAD 3.97351
314 4YRY FAD 3.98551
315 4YRY NAD 3.98551
316 5O42 NAD 4.0146
317 5O42 9JW 4.0146
318 5O42 BGC 4.0146
319 2PV7 NAD 4.02685
320 1JQ3 AAT 4.05405
321 6GNC FAD 4.08163
322 5H81 NAP 4.11311
323 6DWI HD4 4.11523
324 4XDY NAI 4.14201
325 5U8U FAD 4.158
326 5JWC FAD 4.16667
327 2GMH FAD 4.16667
328 1QMG APX 4.16667
329 3CBG SAH 4.16667
330 4NTC FAD 4.1791
331 1GVF PGH 4.1958
332 5KMS NAD 4.19753
333 5KMS FAD 4.19753
334 1PL6 572 4.21348
335 1PL6 NAD 4.21348
336 1DIG NAP 4.24837
337 2RI1 GLP 4.25532
338 4Y9D NAI 4.2623
339 5N0J FAD 4.2735
340 3GFB NAD 4.28571
341 2FZW NAD 4.28954
342 3TWO NDP 4.31034
343 5W75 SUC 4.33673
344 2B4R NAD 4.34783
345 2B4R AES 4.34783
346 3IHG FAD 4.41176
347 5MQ6 NDP 4.41176
348 1P1C SAH 4.41176
349 3NYC FAD 4.46194
350 3NYC IAR 4.46194
351 4BVA NDP 4.47761
352 4BVA T3 4.47761
353 2VYN NAD 4.49102
354 3CMC NAD 4.49102
355 4KOA NDP 4.5045
356 1HYH NAD 4.53074
357 2I3G NAP 4.54545
358 1UAY ADN 4.54545
359 1U1I NAD 4.59184
360 4JK3 NAD 4.6332
361 1NVM NAD 4.63768
362 2QA1 FAD 4.65686
363 4YSX FAD 4.65686
364 2NVK FAD 4.65686
365 2NVK NAP 4.65686
366 4D04 FAD 4.65686
367 4D04 NAP 4.65686
368 1QO8 FAD 4.65686
369 2VVM FAD 4.65686
370 4D7E FAD 4.65686
371 2VVL FAD 4.65686
372 1VI2 NAD 4.66667
373 5DN9 NAD 4.67033
374 1E6E FAD 4.6875
375 5TCI MLI 4.71014
376 6EL3 NAP 4.72441
377 3G89 SAM 4.81928
378 1VM6 NAD 4.82456
379 1NPD NAD 4.86111
380 4W6Z 8ID 4.89914
381 4JDR FAD 4.90196
382 4OPC FDA 4.90196
383 4OPC PGT 4.90196
384 5NMX NAP 4.90196
385 4DSG FAD 4.90196
386 4DSG UDP 4.90196
387 5NMX FAD 4.90196
388 1WDK NAD 4.90196
389 1X14 NAD 4.90196
390 5OFW 9TW 4.93274
391 2XZ9 PYR 4.93827
392 4E13 NAD 4.947
393 3QJ4 FAD 4.97076
394 4CJX NAP 5.01567
395 4J4H NAI 5.01931
396 4J4H 1J1 5.01931
397 4DN8 BMA 5.12821
398 5BRT FAD 5.14706
399 5BRT CH9 5.14706
400 6FP4 FAD 5.14706
401 6FP4 E1T 5.14706
402 5I39 FAD 5.14706
403 2GVC FAD 5.14706
404 2GV8 FAD 5.14706
405 5M67 ADE 5.14706
406 5M67 NAD 5.14706
407 5M67 3D1 5.14706
408 4CP8 MLI 5.14706
409 2GV8 NDP 5.14706
410 1YBH P22 5.14706
411 3SSO SAH 5.14706
412 4D3F NAP 5.16129
413 4USI AKG 5.19481
414 3N8K D1X 5.23256
415 3LLZ GAL NGA 5.26316
416 1RP0 AHZ 5.28169
417 1O0S NAI 5.28926
418 5BVA FAD 5.39216
419 5J5Z FAD 5.39216
420 3NTD FAD 5.39216
421 3NTA FAD 5.39216
422 1LVL FAD 5.39216
423 3NT6 FAD 5.39216
424 5J7X FAD 5.39216
425 1LVL NAD 5.39216
426 2XVE FAD 5.39216
427 1VQW FAD 5.39216
428 2F5Z FAD 5.39216
429 2VTD LKM 5.39216
430 2XVF FAD 5.39216
431 6FA4 D1W 5.39216
432 4YCA NDP 5.44218
433 3ABI NAD 5.47945
434 1NYT NAP 5.53506
435 2Q7V FAD 5.53846
436 4USQ FAD 5.54017
437 4MP8 NAD 5.60472
438 4MP8 MLI 5.60472
439 1FEC FAD 5.63725
440 6ER9 FAD 5.63725
441 6ER9 NAP 5.63725
442 1YY5 FAD 5.63725
443 6C4N NAP 5.63725
444 1V6A TRE 5.63725
445 5Z21 NAI 5.63725
446 5N53 8NB 5.64103
447 1H5Q NAP 5.66038
448 1SC6 NAD 5.69307
449 1J49 NAD 5.70571
450 4UP3 FAD 5.73248
451 4UP3 NDP 5.73248
452 2DFV NAD 5.76369
453 5ZZ6 NAD 5.76923
454 5ZZ6 ADP 5.76923
455 1C0I FAD 5.78512
456 1C0I BE2 5.78512
457 2D2I NAP 5.78947
458 3HDY FDA 5.79345
459 3HDY GDU 5.79345
460 3HDY FAD 5.79345
461 5AYV KPL 5.82524
462 5AYV NAP 5.82524
463 3FPZ AHZ 5.82822
464 3CIF NAD 5.84958
465 3CIF G3H 5.84958
466 4REP FAD 5.85859
467 3G5S FAD 5.88235
468 1V59 FAD 5.88235
469 5TS5 FAD 5.88235
470 1RSG FAD 5.88235
471 4YNU LGC 5.88235
472 4YNU FAD 5.88235
473 1V59 NAD 5.88235
474 3NKS FAD 5.88235
475 2RGH FAD 5.88235
476 4KP7 1UQ 5.88235
477 4KP7 NAP 5.88235
478 4EA7 JB2 5.90909
479 4EA7 COA 5.90909
480 1NVT NAP 5.92335
481 5J60 FAD 5.9375
482 3CTY FAD 5.95611
483 4PLG NAI 5.98802
484 4PLG OXM 5.98802
485 4RPL FAD 6.01504
486 4RPL 3UC 6.01504
487 6GAR FAD 6.01719
488 4PLT NAI 6.0423
489 4PLT OXM 6.0423
490 3E1T FAD 6.05469
491 2F1K NAP 6.09319
492 3QV1 NAD 6.09756
493 1JNR FAD 6.12745
494 2WPF WPF 6.12745
495 2WPF FAD 6.12745
496 2IVD FAD 6.12745
497 2RGO FAD 6.12745
498 2YG3 FAD 6.12745
499 4CQM NAP 6.14754
500 5JY6 NAD 6.17978
501 1T26 GBD 6.21118
502 1T26 NAI 6.21118
503 2A92 NAI 6.23053
504 3SAO DBH 6.25
505 1F06 NDP 6.25
506 1F06 2NP 6.25
507 1I8T FAD 6.26703
508 1YQD NAP 6.28415
509 3HVJ 705 6.33484
510 4USR FAD 6.37119
511 4B4U NAP 6.37255
512 3WLE NAD 6.37255
513 4A69 I0P 6.38298
514 3GF4 UPG 6.41026
515 3GF4 FAD 6.41026
516 3WV8 ATP 6.42202
517 5ZBC FAD 6.43016
518 2CUL FAD 6.46552
519 4JNA FAD 6.47059
520 4RSL FAD 6.51685
521 5ZI9 FLC 6.53846
522 4EMJ FAD 6.54206
523 3L4S NAD 6.54762
524 3L4S 3PG 6.54762
525 3QFA FAD 6.55106
526 3WBF NAP 6.55738
527 3WBF API 6.55738
528 1HDR NAD 6.55738
529 4K5S FAD 6.61765
530 4K5S PM0 6.61765
531 3SQP FAD 6.61765
532 5JCA NDP 6.61765
533 5JCA FAD 6.61765
534 1VDC FAD 6.61765
535 4XQC 13D 6.61765
536 4XQC NAD 6.61765
537 1REO FAD 6.61765
538 1TDF FAD 6.64557
539 1TDF NAP 6.64557
540 1ELI PYC 6.6838
541 2NXE SAM 6.69291
542 5KKA 6V0 6.73077
543 1F8F NAD 6.73854
544 2G5C NAD 6.76157
545 2HK9 ATR 6.86275
546 1H82 GZZ 6.86275
547 1H82 FAD 6.86275
548 2HK9 NAP 6.86275
549 2FKA BEF 6.97674
550 5ZYN FAD 7.00637
551 2CVQ NDP 7.03364
552 5YB7 ORN 7.06897
553 5YB7 FAD 7.06897
554 3S5W FAD 7.10784
555 6A3J NAI 7.10784
556 6A3J SOE 7.10784
557 3S5W NAP 7.10784
558 3GRU AMP 7.11864
559 3A06 NDP 7.18085
560 3KIH GDL 7.2165
561 2EV9 SKM 7.22433
562 2EV9 NAP 7.22433
563 2B9W FAD 7.31132
564 4TM3 FAD 7.35294
565 2VT3 ATP 7.35294
566 5X20 NAD 7.37179
567 2NAD NAD 7.37913
568 5EIN NAP 7.40741
569 2OOR NAD 7.55208
570 1NM5 NAD 7.55208
571 1L7E NAI 7.55208
572 6BQ6 TER 7.55287
573 5YEC ATP 7.56302
574 1LDN NAD 7.59494
575 2IZ1 ATR 7.59804
576 1UWK URO 7.59804
577 1UWK NAD 7.59804
578 1OBB NAD 7.59804
579 6F3M NAD 7.6087
580 6F3N ADN 7.62712
581 6F3N NAD 7.62712
582 5THQ NDP 7.72059
583 3LZW NAP 7.83133
584 3LZW FAD 7.83133
585 2ZXI FAD 7.84314
586 5K0A FAD 7.87879
587 1KEW NAD 8.03324
588 1TL2 NDG 8.05085
589 3LXD FAD 8.08823
590 3HAD NAD 8.11688
591 3FUU ADN 8.11808
592 1BXG NAD 8.14607
593 1BW9 NAD 8.14607
594 1C3V NDP 8.16327
595 1C1X NAD 8.16901
596 3EGI ADP 8.25243
597 2Q46 NAP 8.3004
598 1BZL FAD 8.33333
599 1BZL GCG 8.33333
600 2IID FAD 8.33333
601 2IID PHE 8.33333
602 1I36 NAP 8.33333
603 3QDY A2G GAL 8.39161
604 3QDT A2G GAL 8.39161
605 5EZ7 FAD 8.41837
606 3AXB PRO 8.48214
607 3AXB FAD 8.48214
608 1EZ4 NAD 8.49057
609 1JAY NAP 8.49057
610 4FWE FAD 8.54271
611 1YQZ FAD 8.57843
612 3RNM FAD 8.62069
613 4XB2 NDP 8.65672
614 4XB2 HSE 8.65672
615 4D79 ATP 8.69565
616 2JDU MFU 8.69565
617 4OM8 NAD 8.73786
618 4HSU FAD 8.76289
619 4GUT FAD 8.76289
620 4GUS FAD 8.76289
621 4L8V NAP 8.90208
622 1FWV SGA MAG FUC 8.95522
623 2GUC MAN 9.01639
624 2NU5 NAG 9.01639
625 2HYR BGC GLC 9.01639
626 2NUO BGC 9.01639
627 2GUD BMA 9.01639
628 2GUD MAN 9.01639
629 4H53 SLB 9.02062
630 1KOL NAD 9.04523
631 4C3Y FAD 9.31373
632 4C3Y ANB 9.31373
633 4RDI ATP 9.375
634 4RDH AMP 9.375
635 1PN0 FAD 9.55882
636 1PN0 IPH 9.55882
637 4X9M FAD 9.55882
638 4MIG G3F 9.55882
639 2NPX FAD 9.55882
640 2NPX NAD 9.55882
641 5TWB FAD 9.59302
642 3F8D FAD 9.59752
643 5DF1 NAP 9.78261
644 5DF1 58X 9.78261
645 5BUK FAD 9.80392
646 3GMB FAD 9.80392
647 4U8P FDA 9.80392
648 4U8P UDP 9.80392
649 2Q1S NAI 9.81432
650 1FL2 FAD 10
651 3AD8 NAD 10.101
652 3AD8 PYC 10.101
653 3AD8 FAD 10.101
654 2AG8 NAP 10.2662
655 2BOS GLA GAL GLC NBU 10.2941
656 2BOS GLA GAL GLC 10.2941
657 3VPH OXM 10.3226
658 3VPH NAD 10.3226
659 1A5Z NAD 10.3448
660 4YUW S4M 10.5263
661 4YUW 4JU 10.5263
662 2FWP ICR 10.5392
663 2DC1 NAD 10.5932
664 3B1F NAD 10.6897
665 2GSD NAD 10.6965
666 5HXI FAD 10.8179
667 5HXI 5HN 10.8179
668 6GAS FAD 10.8761
669 5EES NAP 10.9312
670 3ITJ FAD 10.9467
671 3ITJ CIT 10.9467
672 2GAG NAD 10.9524
673 2GAG FOA 10.9524
674 2GAG FAD 10.9524
675 5MIT FAD 11.0092
676 5MIT NAP 11.0092
677 6AA8 NAD 11.2583
678 1VL0 NAI 11.3014
679 3KIF GDL 11.3208
680 4J56 FAD 11.4035
681 3GGO NAI 11.465
682 3GGO ENO 11.465
683 5CSS G3P 11.9469
684 3H8V ATP 11.9863
685 1GR0 NAD 11.9891
686 2C7G ODP 12.0098
687 2C7G FAD 12.0098
688 5A1T NAI 12.0235
689 2HJR APR 12.1951
690 3UOY NAP 12.2549
691 3UOY FAD 12.2549
692 3OZ2 FAD 12.3426
693 3A27 SAM 12.8676
694 1GTE FAD 13.4804
695 3OJO NAD 14.2157
696 1GET FAD 14.4608
697 1GET NAP 14.4608
698 4AT0 FAD 14.4608
699 1JG3 ADN 14.4681
700 5C2N NAG 14.5833
701 3ORF NAD 14.741
702 1LLU NAD 15.2047
703 5ODQ FAD 15.7143
704 2HMT NAI 16.6667
705 3H9E NAD 16.763
706 3T31 DCQ 16.9118
707 3T31 FAD 16.9118
708 1R37 NAD 17.0029
709 2Z3Y F2N 18.3824
710 5KOX FAD 18.8725
711 5KOX RFP 18.8725
712 5F6U 5VK 19.7452
713 5AN1 GSH 20.5479
714 5YRI GLC GLC 21.1268
715 5YRF GLC GLC 21.1268
716 1LSS NAD 21.4286
717 2E5V FAD 22.549
718 5L95 AMP 22.9391
719 4II2 ATP 25.3012
720 6AIN FAD 25.3589
721 5EVY FAD 28.6765
722 4BJZ P3A 29.717
723 4BJZ FAD 29.717
724 5X68 FAD 31.7136
725 4EIP FAD 32.8431
726 4EIP K2C 32.8431
727 6FHO FAD 33.584
728 5Y77 FAD 35.0951
729 2RGJ FAD 35.3234
730 5EOW FAD 35.5556
731 4J36 FAD 40.1961
732 4J36 1HR 40.1961
733 5MZI FAD 40.1961
734 5MZI FYK 40.1961
735 2Y6Q I7T 42.4623
736 2Y6Q FAD 42.4623
Pocket No.: 2; Query (leader) PDB : 5TUK; Ligand: FAD; Similar sites found with APoc: 13
This union binding pocket(no: 2) in the query (biounit: 5tuk.bio1) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 6BK3 UDP 1.96078
2 2AOT SAH 2.05479
3 3W9F I3P 2.69231
4 2D5A COA 3.47222
5 6EV2 BGC 4.5045
6 4B2D SER 4.65686
7 5A1S FLC 5.63725
8 5C9P FUC 6.29921
9 5FUI APY 6.81818
10 4X7Y SAH 8.0292
11 3W68 4PT 8.27068
12 1OD3 BGC BGC 17.8571
13 4R3U 5AD 29.1139
Pocket No.: 3; Query (leader) PDB : 5TUK; Ligand: FAD; Similar sites found with APoc: 9
This union binding pocket(no: 3) in the query (biounit: 5tuk.bio4) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 4XYB NDP 1.27877
2 2GND MAN MMA 2.38095
3 1ON3 DXX 4.41176
4 3QH2 3NM 4.97738
5 5OF1 SAL 7.14286
6 3QDX A2G GAL 8.39161
7 3KP6 SAL 9.27152
8 3OFK SAH 12.5
9 2ZHZ ATP 15.3005
Pocket No.: 4; Query (leader) PDB : 5TUK; Ligand: FAD; Similar sites found with APoc: 94
This union binding pocket(no: 4) in the query (biounit: 5tuk.bio2) has 31 residues
No: Leader PDB Ligand Sequence Similarity
1 2Z48 NGA 1.71569
2 1ZEM NAD 1.9084
3 4DPL NAP 1.94986
4 3N75 G4P 1.96078
5 5WP5 SAH 1.96078
6 1XF1 CIT 1.96078
7 5Y8L HUI 2.0339
8 4UP4 NAG 2.24439
9 4DMG SAM 2.29008
10 4YAC NAI 2.3569
11 3DMH SAM 2.3622
12 4R5M NAP 2.39362
13 1FUR MLT 2.45098
14 3X0D SAH 2.45098
15 1IM8 SAI 2.45902
16 5E5U MLT 2.51256
17 5E9W SAH 2.5641
18 2P69 PLP 2.61438
19 4M38 SAH 2.62391
20 5FA5 MTA 2.69608
21 3PT9 SAH 2.69608
22 5MDH NAD 2.7027
23 3ESS 18N 2.94118
24 4I7E PEP 3.1348
25 2VAR AMP 3.19489
26 4DCM SAM 3.2
27 3A4T SFG 3.28467
28 5T9E NAP 3.32103
29 2EB5 OXL 3.37079
30 4OEV OXL 3.43137
31 3PGU OLA 3.43137
32 5ZI2 ADP 3.47826
33 1L1E SAH 3.48432
34 2XVM SAH 3.51759
35 3CL7 HYN 3.57143
36 4XDA ADP 3.8835
37 1DL5 SAH 4.10095
38 3KB6 NAD 4.19162
39 2O07 MTA 4.27632
40 2O07 SPD 4.27632
41 4C4A SAH 4.41176
42 2YX1 SFG 4.46429
43 3MAG SAH 4.56026
44 3GFS FMN 4.5977
45 4XDZ NDP 4.66472
46 1XCL SAH 4.68085
47 1BGV GLU 5.14706
48 3AKK ADP 5.23077
49 3VSE SAH 5.77889
50 2P39 SCR 5.80645
51 2PT9 S4M 5.919
52 2PT9 2MH 5.919
53 4XUC SAM 5.9633
54 4XUC 43G 5.9633
55 3G2O SAM 6.02007
56 2JGV ADP 6.06061
57 1GZ6 NAI 6.26959
58 3NOJ PYR 6.30252
59 3WQQ NDP 6.35246
60 3WQQ IB3 6.35246
61 2FK8 SAM 6.60377
62 3BAZ NAP 6.60661
63 3A25 SAM 6.64452
64 1DCP HBI 6.73077
65 2ZIF SAM 6.73401
66 2JBH 5GP 6.86275
67 3CYQ AMU 7.24638
68 5KVS NAP 7.27273
69 2P4Q FLC 7.35294
70 3RGG AIR 7.54717
71 3LCC SAH 7.65957
72 4MCC 21X 7.72358
73 1HE1 AF3 7.95455
74 1CF2 NAP 8.01187
75 2G30 ALA ALA PHE 8.13953
76 4R6W PC 8.13953
77 1C3V PDC 8.16327
78 4YAG NAI 8.65052
79 5FIT AP2 8.84354
80 2IXE ATP 9.22509
81 2YYY NAP 9.62099
82 1C4Q GLA GAL BGC 10.1449
83 1XXA ARG 10.2564
84 2FWP CIT 10.5392
85 5XVH NAP 10.7843
86 1EJ0 SAM 11.6667
87 2VDV SAM 12.6016
88 3HP8 SUC 12.7273
89 3AI3 SOE 13.308
90 4QTU SAM 14.0741
91 5Z2F PDC 14.3396
92 5ZW3 SAH 17.3333
93 5E8J SAH 20.4545
94 3DUW SAH 26.4574
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