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Receptor
PDB id Resolution Class Description Source Keywords
5URY 2.1 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF FRIZZLED 5 CRD IN COMPLEX WITH PAM HOMO SAPIENS FRIZZLED 5 CRD SIGNALING PROTEIN
Ref.: UNSATURATED FATTY ACYL RECOGNITION BY FRIZZLED RECE MEDIATES DIMERIZATION UPON WNT LIGAND BINDING. PROC. NATL. ACAD. SCI. V. 114 4147 2017 U.S.A.
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NAG FUC FUC FUC A:201;
Invalid;
none;
submit data n/a n/a n/a n/a
PAM B:201;
A:205;
Valid;
Valid;
none;
none;
submit data
254.408 C16 H30 O2 CCCCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5URY 2.1 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF FRIZZLED 5 CRD IN COMPLEX WITH PAM HOMO SAPIENS FRIZZLED 5 CRD SIGNALING PROTEIN
Ref.: UNSATURATED FATTY ACYL RECOGNITION BY FRIZZLED RECE MEDIATES DIMERIZATION UPON WNT LIGAND BINDING. PROC. NATL. ACAD. SCI. V. 114 4147 2017 U.S.A.
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1443 families.
1 5URZ - BOG C14 H28 O6 CCCCCCCCO[....
2 5URY - PAM C16 H30 O2 CCCCCCC=C/....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1205 families.
1 5URZ - BOG C14 H28 O6 CCCCCCCCO[....
2 5URY - PAM C16 H30 O2 CCCCCCC=C/....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1039 families.
1 5URZ - BOG C14 H28 O6 CCCCCCCCO[....
2 5URY - PAM C16 H30 O2 CCCCCCC=C/....
3 5URV - NER C24 H46 O2 CCCCCCCCC=....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: PAM; Similar ligands found: 54
No: Ligand ECFP6 Tc MDL keys Tc
1 VCA 1 1
2 PAM 1 1
3 ELA 0.939394 1
4 OLA 0.939394 1
5 NER 0.939394 1
6 MYZ 0.852941 0.954545
7 EIC 0.725 0.956522
8 ODD 0.675 0.956522
9 X90 0.666667 0.954545
10 TDA 0.666667 0.954545
11 STE 0.666667 0.954545
12 EW8 0.666667 0.954545
13 F15 0.666667 0.954545
14 MYR 0.666667 0.954545
15 F23 0.666667 0.954545
16 DCR 0.666667 0.954545
17 11A 0.666667 0.954545
18 DAO 0.666667 0.954545
19 KNA 0.666667 0.954545
20 PLM 0.666667 0.954545
21 DKA 0.666667 0.954545
22 OCA 0.636364 0.954545
23 RCL 0.625 0.88
24 LNL 0.613636 0.869565
25 SHV 0.606061 0.909091
26 KTC 0.564103 0.84
27 ODT 0.555556 0.826087
28 T25 0.54717 0.709677
29 AZ1 0.53125 0.615385
30 10X 0.529412 0.645161
31 6NA 0.529412 0.863636
32 10Y 0.529412 0.645161
33 3X1 0.525 0.863636
34 243 0.519231 0.846154
35 MVC 0.519231 0.617647
36 VA 0.511111 0.692308
37 OLC 0.490566 0.617647
38 OLB 0.490566 0.617647
39 ACD 0.488889 0.956522
40 EOD 0.468085 0.677419
41 78N 0.444444 0.617647
42 78M 0.444444 0.617647
43 3LA 0.44186 0.769231
44 LEA 0.441176 0.772727
45 T24 0.438596 0.769231
46 BRC 0.435897 0.64
47 M12 0.428571 0.833333
48 MPG 0.425926 0.617647
49 9OD 0.422222 0.72
50 14V 0.413043 0.714286
51 BMJ 0.4 0.913043
52 D0G 0.4 0.913043
53 14U 0.4 0.678571
54 BNV 0.4 0.913043
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5URY; Ligand: PAM; Similar sites found with APoc: 460
This union binding pocket(no: 1) in the query (biounit: 5ury.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 3RWP ABQ None
2 4KVX ACO None
3 5XJ7 87O None
4 3GWN FAD None
5 1AWI PRO PRO PRO PRO PRO PRO PRO PRO PRO PRO None
6 2ZFZ ARG None
7 5JPH COA None
8 3GWL FAD None
9 1LAF ARG None
10 1D1G NDP None
11 1M4I COA None
12 1M4I KAN None
13 1M4I PAP None
14 2BME GNP None
15 4OAS 2SW None
16 3KFC 61X None
17 4WT2 3UD None
18 6FS8 E4Z None
19 4LXQ TYD None
20 4LXQ FON None
21 2QZO KN1 None
22 3ZCB ATP None
23 2QE4 JJ3 None
24 6ARJ SAH None
25 1G16 GDP None
26 5XJ8 NKO None
27 1IY8 NAD None
28 2WPW ACO None
29 4HBM 0Y7 None
30 3KPE TM3 None
31 1QAW TRP None
32 1EYQ NAR None
33 1NJF AGS None
34 2WPX ACO None
35 3ZC7 ATP None
36 1DMH LIO None
37 2YI0 YI0 None
38 5T2Z 017 None
39 4CNK FAD 1.36986
40 1GHE ACO 1.36986
41 3EWK FAD 1.36986
42 1AXW MTX 1.36986
43 3QKT ANP 1.36986
44 4UA3 COA 1.36986
45 2DT9 THR 1.36986
46 3T50 FMN 1.5625
47 4AVB ACO 2.05479
48 1V0C KNC 2.05479
49 1V0C ACO 2.05479
50 4BFW ZVW 2.05479
51 5K53 STE 2.05479
52 5FQK 6NT 2.05479
53 5B0I BOG 2.05479
54 3WYJ H78 2.05479
55 4B7X NAP 2.05479
56 1ZAP A70 2.05479
57 2IYA UDP 2.05479
58 6C28 WCA 2.05479
59 5UC1 486 2.05479
60 5EEH SAH 2.05479
61 3MBG FAD 2.15827
62 5CQG 55C 2.73973
63 2Z7I 742 2.73973
64 1TMX HGX 2.73973
65 3D9F N6C 2.73973
66 4J7U NAP 2.73973
67 2ZKJ ADP 2.73973
68 3D9F FAD 2.73973
69 1OAA OAA 2.73973
70 5V2J 7WV 2.73973
71 5V2J UDP 2.73973
72 5J6A P46 2.73973
73 2P4Y C03 2.73973
74 5UR6 8KM 2.73973
75 2HFP NSI 2.73973
76 4U9W COA 2.73973
77 1G0N NDP 2.73973
78 1G0N PHH 2.73973
79 2C0U FAD NBT 2.73973
80 5AE2 FYC 2.73973
81 5AE2 FAD 2.73973
82 4J7U YTZ 2.73973
83 2AG5 NAD 2.73973
84 4WP9 ZDA 2.73973
85 1V9N NDP 2.73973
86 1W78 ADP 2.73973
87 1N1G BCP 2.73973
88 1W78 PD8 2.73973
89 1Q2C COA 2.73973
90 3E2M E2M 2.73973
91 2RH4 EMO 3.2491
92 3D78 NBB 3.36134
93 5LOF 70R 3.42466
94 4AT0 FAD 3.42466
95 2VTD LKM 3.42466
96 1ITZ TPP 3.42466
97 4C3Y ANB 3.42466
98 3G5N PB2 3.42466
99 1TKB N1T 3.42466
100 3DFR NDP 3.42466
101 5EOB 5QQ 3.42466
102 1SR7 MOF 3.42466
103 1SVK ALF GDP 3.42466
104 5OYH T99 3.42466
105 1JGT CMA 3.42466
106 1JGT APC 3.42466
107 2Z5F A3P 3.42466
108 1ZDU P3A 3.42466
109 1YOK P6L 3.42466
110 1LPD ADE 3.42466
111 2CK3 ADP 3.42466
112 1BH2 GSP 3.42466
113 3QVV 3QV 3.42466
114 3QVV A3P 3.42466
115 2OM2 GDP 3.42466
116 1Y3A GDP 3.42466
117 4C3Y FAD 3.42466
118 3IA4 NDP 3.7037
119 3IA4 MTX 3.7037
120 4US3 TRP 4.10959
121 3RG9 NDP 4.10959
122 3RG9 WRA 4.10959
123 3HIW C2X 4.10959
124 2VCH UDP 4.10959
125 2R5N TPP 4.10959
126 2R5N R5P 4.10959
127 2R5N RP5 4.10959
128 3F8K COA 4.10959
129 3HBF MYC 4.10959
130 3HBF UDP 4.10959
131 1OZH HE3 4.10959
132 4KCL H4B 4.10959
133 4KCL H44 4.10959
134 1KNR FAD 4.10959
135 5YS9 FAD 4.10959
136 3EEL 53T 4.10959
137 4H6U ACO 4.10959
138 2C1X UDP 4.10959
139 1U70 MTX 4.10959
140 1U70 NDP 4.10959
141 4PJT 2YQ 4.10959
142 4UXH T5A 4.10959
143 1G3M A3P 4.10959
144 1G3M PCQ 4.10959
145 4HE2 AMP 4.10959
146 2Q7V FAD 4.10959
147 1BGQ RDC 4.10959
148 1LFD GNP 4.10959
149 3PMA SCR 4.10959
150 1Z6T ADP 4.10959
151 4C5N ACP 4.10959
152 1AQU A3P 4.10959
153 1NVM NAD 4.10959
154 4M4Q 21A 4.10959
155 4UXL 5P8 4.10959
156 1KQP ADJ 4.10959
157 1JA9 PYQ 4.10959
158 1T36 U 4.10959
159 4ONC 40B 4.10959
160 3AB4 THR 4.10959
161 5UQW GDP 4.10959
162 2C5L GTP 4.10959
163 6EOA FMN 4.10959
164 3QBT GNP 4.28571
165 3U2U UDP 4.56274
166 5LJ0 6XX 4.61538
167 1QO8 FAD 4.79452
168 1U72 NDP 4.79452
169 1U72 MTX 4.79452
170 2O3Z AI7 4.79452
171 6EOP F15 4.79452
172 3ZUY TCH 4.79452
173 1LLF F23 4.79452
174 4C2X NHW 4.79452
175 6EDV COA 4.79452
176 2WSA 646 4.79452
177 2WSA MYA 4.79452
178 1DR1 NAP 4.79452
179 1DR1 HBI 4.79452
180 3HWW AKG 4.79452
181 5MU6 MYA 4.79452
182 5MU6 KFK 4.79452
183 4PPU TYR 4.79452
184 4OIV XX9 4.79452
185 3CRZ NAP 4.79452
186 4Z87 GDP 4.79452
187 3FSJ D7K 4.79452
188 3QWI CUE 4.79452
189 4Q9M FPP 4.79452
190 4Q9M 2ZW 4.79452
191 2QV7 ADP 4.79452
192 4WOP CTP 4.79452
193 3VBK 0FX 4.79452
194 1WQ1 GDP 4.79452
195 4DP3 MMV 4.79452
196 4DP3 NDP 4.79452
197 1UA7 ACI GLD GLC ACI G6D BGC 4.79452
198 5W7U GY8 4.79452
199 1TAD ALF 4.79452
200 1TAD GDP 4.79452
201 2FZH DH1 4.79452
202 4ZON 4Q1 4.79452
203 6DIO NAD 4.79452
204 4AG9 COA 4.79452
205 6AU6 GDP 4.79452
206 3SCM LGN 4.79452
207 3VBK COA 4.79452
208 1E96 GTP 4.79452
209 3QXC ATP 4.79452
210 6FCX FAD 4.79452
211 5HGZ ACO 4.79452
212 3I53 SAH 4.79452
213 5J62 FMN 4.79452
214 3Q72 GNP 4.79452
215 5HH0 COA 4.79452
216 4NSQ COA 4.79452
217 1XNG ATP 4.79452
218 2WKQ FMN 4.79452
219 2ZJ5 ADP 4.79452
220 3X1M COA 5.03145
221 2VBU CDP 5.14706
222 1Q9I FAD 5.47945
223 1Q9I TEO 5.47945
224 2AE2 PTO 5.47945
225 2AE2 NAP 5.47945
226 3LN0 52B 5.47945
227 5W6Y TRP 5.47945
228 6EXS C3H 5.47945
229 4CJX NAP 5.47945
230 2X7J TPP 5.47945
231 4ELG 52J 5.47945
232 4KCF AKM 5.47945
233 3SFI 3SF 5.47945
234 5AJU RP5 5.47945
235 5EOW FAD 5.47945
236 5LX9 OLB 5.47945
237 4GYW UDP 5.47945
238 2VK4 TPP 5.47945
239 1IYK MYA 5.47945
240 4X1T UDP 5.47945
241 1F5V FMN 5.47945
242 4J56 FAD 5.47945
243 5G5G MCN 5.47945
244 1M7Y PPG 5.47945
245 3N7H DE3 5.6
246 5OBY ANP 5.61497
247 2EVL GAL SPH EIC 6.16438
248 4XPL ACO 6.16438
249 3WR7 COA 6.16438
250 6BA2 7KM 6.16438
251 1YKI NFZ 6.16438
252 5ESO TDP 6.16438
253 5ESO ISC 6.16438
254 1Q19 SSC 6.16438
255 1AOE NDP 6.16438
256 1AOE GW3 6.16438
257 3D2M COA 6.16438
258 2VSU ACO 6.16438
259 4A1O JLN 6.16438
260 1I1D 16G 6.16438
261 1I1D COA 6.16438
262 2NUN ADP 6.16438
263 1SC6 NAD 6.16438
264 5OBU ANP 6.16438
265 5GUD NDP 6.16438
266 4U0S ADP 6.16438
267 5GUD CIT 6.16438
268 2H7C COA 6.16438
269 3APT FAD 6.16438
270 2VHJ ADP 6.16438
271 3P0K FAD 6.16438
272 6CRK GDP 6.16438
273 3ZCN ATP 6.16438
274 3P7N FMN 6.16438
275 5FJJ MAN 6.16438
276 2CE7 ADP 6.16438
277 4OGQ 2WM 6.16438
278 5LWY OLB 6.72269
279 1NHX FTB 6.84932
280 1NHX PEP 6.84932
281 2GMV UN8 6.84932
282 5NTP 98E 6.84932
283 5WL1 D3D 6.84932
284 5WL1 CUY 6.84932
285 3KC1 2T6 6.84932
286 5ND5 TPP 6.84932
287 5DM1 5D7 6.84932
288 2JJK R15 6.84932
289 5Y9D FAD 6.84932
290 4P3H 25G 6.84932
291 5HWO HMG 6.84932
292 2GWH A3P 6.84932
293 2IHU TP9 6.84932
294 3F4F UMP 6.84932
295 2ZW5 COA 6.84932
296 5ODQ FAD 6.84932
297 4NB5 2JT 6.84932
298 2C6Q NDP 6.84932
299 4XDA ADP 6.84932
300 2C6Q IMP 6.84932
301 5N81 8Q2 6.84932
302 6A5Y 9R0 6.84932
303 5C5H 4YB 6.84932
304 1IHU ADP 6.84932
305 1IHU AF3 6.84932
306 4P7U 1PS 7.14286
307 2HJ3 FAD 7.2
308 5LS7 ACO 7.31707
309 2DRC MTX 7.53425
310 4OJ8 2TQ 7.53425
311 1P0H ACO 7.53425
312 1P0H COA 7.53425
313 4UMX NAP 7.53425
314 4UMX VVS 7.53425
315 3NW7 LGV 7.53425
316 4OJ8 AKG 7.53425
317 5WO4 B7V 7.53425
318 4TWP AXI 7.53425
319 1GPE FAD 7.53425
320 1UBY DMA 7.53425
321 5EYK 5U5 7.53425
322 2WOJ ADP ALF 7.53425
323 3ZS9 ADP ALF 7.53425
324 3RUV ANP 7.53425
325 1OQC FAD 8
326 6HH6 A3R 8.21918
327 5OLZ T4E 8.21918
328 2CNT COA 8.21918
329 2BL9 NDP 8.21918
330 4PVV HO4 8.21918
331 4ITM ATP 8.21918
332 2ZCQ B65 8.21918
333 2ACV UDP 8.21918
334 5ZYN FAD 8.21918
335 2BL9 CP6 8.21918
336 4LY9 S6P 8.21918
337 4LY9 1YY 8.21918
338 2X06 NAD 8.21918
339 2GZ3 NAP 8.21918
340 6BK3 UDP 8.21918
341 2AQJ TRP 8.21918
342 3MDV CL6 8.21918
343 4GO7 THR 8.21918
344 4RC8 STE 8.21918
345 1S7N COA 8.21918
346 4WRI OKA 8.21918
347 1GQ2 NAP 8.21918
348 3S2U UD1 8.21918
349 1NLI ADE 8.90411
350 2NXW TPP 8.90411
351 1J3I WRA 8.90411
352 1R9J TPP 8.90411
353 1GP2 GDP 8.90411
354 3AB3 GDP 8.90411
355 1J3I NDP 8.90411
356 5KDO GDP 8.90411
357 3PFD FDA 8.90411
358 4YSX FAD 8.90411
359 2JLD AG1 8.90411
360 3OKI OKI 8.90411
361 1GOT GDP 8.90411
362 2PZ8 APC 8.90411
363 3F7Z 34O 8.90411
364 2WOE AR6 8.90411
365 4XB4 45D 8.90411
366 4PFW MAN MAN BMA BMA BMA BMA 8.90411
367 4PNE SAH 8.90411
368 1V3S ATP 9.48276
369 2VBF TPP 9.58904
370 2YNE YNE 9.58904
371 2YNE NHW 9.58904
372 2YNC YNC 9.58904
373 4OHU NAD 9.58904
374 4OHU 2TK 9.58904
375 1JUV NDP 9.58904
376 1OYJ GSH 9.58904
377 1FQK GDP 9.58904
378 2OFW ADX 9.58904
379 1ZPD DPX 9.58904
380 2G86 UMP 10.274
381 4KXL 6C6 10.274
382 4P5E N6P 10.274
383 2BIF BOG 10.274
384 3WQM B29 10.274
385 4R2I ANP 10.274
386 2ODE ALF GDP 10.6383
387 3IX9 MTX 10.9589
388 4M7V RAR 10.9589
389 3NRR D16 10.9589
390 2BW7 APC 10.9589
391 4RJK TDL 10.9589
392 3NRR NAP 10.9589
393 3OZ2 OZ2 10.9589
394 4R57 ACO 10.9589
395 4RJK TPP 10.9589
396 5WKC TP9 11.6438
397 2ZPA ACO 12.3288
398 2Q8M AMP 12.3288
399 2DC1 CIT 12.3288
400 4HCX NDP 12.3288
401 5K0S 0OU 12.3288
402 2DYS PGV 12.7753
403 5ZCO PGV 12.7753
404 5Z84 TGL 12.7753
405 5Z84 PGV 12.7753
406 2DYR PGV 12.7753
407 5ZCO TGL 12.7753
408 3RET SAL 12.8713
409 4KM2 TOP 13.0137
410 4KM2 ATR 13.0137
411 2CIG 1DG 13.0137
412 5UI2 EQ3 13.0137
413 1YRO GDU 13.0137
414 2R40 EPH 13.0137
415 4LAE 1VM 13.1737
416 4LAE NAP 13.1737
417 4LIK CIT 13.6986
418 3W9F I3P 13.6986
419 4FG8 ATP 13.6986
420 1FQJ GDP 14.2857
421 3KDU NKS 14.3836
422 2CWH PYC 14.3836
423 2CWH NDP 14.3836
424 2W9S NDP 14.3836
425 1K7L 544 14.3836
426 1JBW ACQ 14.3836
427 1NLM UD1 14.3836
428 1QPB TPP 14.3836
429 1BOB ACO 14.3836
430 1MZC FPP 15.0685
431 1MZC BNE 15.0685
432 4M73 SAH 15.0685
433 5HRA DAS 15.0685
434 2YC5 6BC 15.7534
435 1P72 ADP 15.7534
436 2YYJ 4HP 15.7534
437 2YYJ FAD 15.7534
438 4ZVV GN0 17.1233
439 4ZVV NAD 17.1233
440 5L3V GDP 17.1233
441 3CX8 GSP 17.8082
442 5MT9 SRO 19.0476
443 5MT9 ARG 19.0476
444 1H9G COA MYR 19.1781
445 3KJS NAP 19.1781
446 2VSS ACO 19.1781
447 3KJS DQ1 19.1781
448 3V66 D3A 19.1781
449 5CSM TRP 19.863
450 1CS4 GSP 19.863
451 1CS4 FOK 19.863
452 1CS4 101 19.863
453 4B6C B5U 19.863
454 4EIL NDP 20.5479
455 4EIL FOL 20.5479
456 1I00 UMP 21.9178
457 1I00 D16 21.9178
458 1RLZ NAD 23.2877
459 4EN4 GT0 26.7123
460 5GK9 ACO 40
Pocket No.: 2; Query (leader) PDB : 5URY; Ligand: PAM; Similar sites found with APoc: 67
This union binding pocket(no: 2) in the query (biounit: 5ury.bio1) has 10 residues
No: Leader PDB Ligand Sequence Similarity
1 2JDC CAO None
2 5AAV GW5 None
3 1QSM ACO None
4 4WUJ FMN None
5 5K52 OCD 1.36986
6 2A3I C0R 2.05479
7 3QKD HI0 2.20994
8 5YJF SAH 3.42466
9 2B4D COA 3.42466
10 4I4B NAD 3.42466
11 5WX3 COA 3.42466
12 2PR5 FMN 3.78788
13 2WET FAD 4.10959
14 3UR0 SVR 4.10959
15 4U31 MVP 4.10959
16 5B4B LP5 4.10959
17 1CLU DBG 4.10959
18 3OZV ECN 4.79452
19 3OZV FAD 4.79452
20 3F8D FAD 4.79452
21 1XVB BHL 4.79452
22 5MW4 5JU 4.79452
23 5AWM ANP 4.79452
24 3RGA ILD 4.79452
25 3G08 FEE 4.79452
26 5FB3 NDP 4.79452
27 1E1O LYS 4.79452
28 5KBZ 3B2 5.47945
29 1E6E FAD 5.47945
30 3A16 PXO 5.47945
31 1XDY MTE 5.47945
32 2DT5 NAD 6.16438
33 5A4W QCT 6.16438
34 2APC UDM 6.16438
35 4RPO T6C 6.16438
36 1USR DAN 6.16438
37 4G2R H1L 6.16438
38 3GGO NAI 6.16438
39 2PT9 S4M 6.84932
40 2PT9 2MH 6.84932
41 4YRY FAD 6.84932
42 2I7C AAT 6.84932
43 4B7H NDP 6.84932
44 3BEJ MUF 7.53425
45 4FJU NAI 7.53425
46 5FAL COA 7.53425
47 5FAL SKT 7.53425
48 4FJU GLV 7.53425
49 2FGE ALA ALA LEU THR ARG ALA 7.53425
50 3QCJ NX4 8.21918
51 5U3B 7TD 8.21918
52 4UDB CV7 8.21918
53 3RUU 37G 8.21918
54 2X5W K2B 8.40909
55 1EGD FAD 8.90411
56 5TUX ECH 8.90411
57 4MIB 28M 9.58904
58 5I34 IMP 9.58904
59 3O55 FAD 9.6
60 2Y31 SMQ 10.274
61 1JQI FAD 10.274
62 2PA4 UPG 11.6438
63 5ZZ6 NAD 12.3288
64 2RHQ GAX 13.6986
65 1XK9 P34 13.6986
66 3DCT 064 14.2857
67 4QC6 30N 14.3836
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