Receptor
PDB id Resolution Class Description Source Keywords
6ALO 1.79 Å EC: 1.14.11.41 VIOC L-ARGININE HYDROXYLASE BOUND TO FE(II), L-ARGININE, AND PEROXYSUCCINATE INTERMEDIATE STREPTOMYCES VINACEUS HYDROXYLASE 2-OXO-GLUTARATE IRON OXIDOREDUCTASE
Ref.: VISUALIZING THE REACTION CYCLE IN AN IRON(II)- AND 2-(OXO)-GLUTARATE-DEPENDENT HYDROXYLASE. J. AM. CHEM. SOC. V. 139 13830 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
OKG A:403;
 Valid;
 none;
 submit data
133.079 C4 H5 O5 C(CC(...
FE2 A:401;
 Part of Protein;
 none;
 submit data
55.845 Fe [Fe+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WBQ 1.1 Å EC: 1.14.11.41 CRYSTAL STRUCTURE OF VIOC IN COMPLEX WITH (2S,3S)- HYDROXYARGININE STREPTOMYCES VINACEUS OXIDOREDUCTASE NON-HEME FE(II) HYDROXYLASE CBETA- HYDROXYLATION L-ARGININE OXYGENASE NRPS VIOMYCIN ALPHA-KETOGLUTARATE
Ref.: STRUCTURAL BASIS FOR THE ERYTHRO-STEREOSPECIFICITY OF THE L-ARGININE OXYGENASE VIOC IN VIOMYCIN BIOSYNTHESIS. FEBS J. V. 276 3669 2009
Members (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6DAX - HRG C7 H16 N4 O2 C(CCNC(=N)....
2 2WBO - TLA C4 H6 O6 [C@@H]([C@....
3 6ALP - SIN C4 H6 O4 C(CC(=O)O)....
4 2WBP - SIN C4 H6 O4 C(CC(=O)O)....
5 6ALO - OKG C4 H5 O5 C(CC(=O)O[....
6 6MP9 - JX7 C6 H11 N3 O3 [H]/N=C(/N....
7 6ALM - AKG C5 H6 O5 C(CC(=O)O)....
8 6Y0N - AKG C5 H6 O5 C(CC(=O)O)....
9 6DB2 - SIN C4 H6 O4 C(CC(=O)O)....
10 6ALN - AKG C5 H6 O5 C(CC(=O)O)....
11 6ALQ - SIN C4 H6 O4 C(CC(=O)O)....
12 6MP8 - DAR C6 H15 N4 O2 C(C[C@H](C....
13 6DAZ - SIN C4 H6 O4 C(CC(=O)O)....
14 6ALR - SIN C4 H6 O4 C(CC(=O)O)....
15 6Y12 - ZZU C6 H14 N4 O3 C(CNC(=N)N....
16 2WBQ - ZZU C6 H14 N4 O3 C(CNC(=N)N....
70% Homology Family (16)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6DAX - HRG C7 H16 N4 O2 C(CCNC(=N)....
2 2WBO - TLA C4 H6 O6 [C@@H]([C@....
3 6ALP - SIN C4 H6 O4 C(CC(=O)O)....
4 2WBP - SIN C4 H6 O4 C(CC(=O)O)....
5 6ALO - OKG C4 H5 O5 C(CC(=O)O[....
6 6MP9 - JX7 C6 H11 N3 O3 [H]/N=C(/N....
7 6ALM - AKG C5 H6 O5 C(CC(=O)O)....
8 6Y0N - AKG C5 H6 O5 C(CC(=O)O)....
9 6DB2 - SIN C4 H6 O4 C(CC(=O)O)....
10 6ALN - AKG C5 H6 O5 C(CC(=O)O)....
11 6ALQ - SIN C4 H6 O4 C(CC(=O)O)....
12 6MP8 - DAR C6 H15 N4 O2 C(C[C@H](C....
13 6DAZ - SIN C4 H6 O4 C(CC(=O)O)....
14 6ALR - SIN C4 H6 O4 C(CC(=O)O)....
15 6Y12 - ZZU C6 H14 N4 O3 C(CNC(=N)N....
16 2WBQ - ZZU C6 H14 N4 O3 C(CNC(=N)N....
50% Homology Family (25)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6DAX - HRG C7 H16 N4 O2 C(CCNC(=N)....
2 2WBO - TLA C4 H6 O6 [C@@H]([C@....
3 6ALP - SIN C4 H6 O4 C(CC(=O)O)....
4 2WBP - SIN C4 H6 O4 C(CC(=O)O)....
5 6ALO - OKG C4 H5 O5 C(CC(=O)O[....
6 6MP9 - JX7 C6 H11 N3 O3 [H]/N=C(/N....
7 6ALM - AKG C5 H6 O5 C(CC(=O)O)....
8 6Y0N - AKG C5 H6 O5 C(CC(=O)O)....
9 6DB2 - SIN C4 H6 O4 C(CC(=O)O)....
10 6ALN - AKG C5 H6 O5 C(CC(=O)O)....
11 6ALQ - SIN C4 H6 O4 C(CC(=O)O)....
12 6MP8 - DAR C6 H15 N4 O2 C(C[C@H](C....
13 6DAZ - SIN C4 H6 O4 C(CC(=O)O)....
14 6ALR - SIN C4 H6 O4 C(CC(=O)O)....
15 6Y12 - ZZU C6 H14 N4 O3 C(CNC(=N)N....
16 2WBQ - ZZU C6 H14 N4 O3 C(CNC(=N)N....
17 6DAW - ARG C6 H15 N4 O2 C(C[C@@H](....
18 4M2G - 2OR C6 H15 N4 O4 C([C@H]([C....
19 4M26 - ZZU C6 H14 N4 O3 C(CNC(=N)N....
20 4M2E - HRG C7 H16 N4 O2 C(CCNC(=N)....
21 4M2C - DAR C6 H15 N4 O2 C(C[C@H](C....
22 4M25 - AKG C5 H6 O5 C(CC(=O)O)....
23 4M2F - GGB C5 H12 N4 O3 [H]/N=C(N)....
24 4M27 - ARG C6 H15 N4 O2 C(C[C@@H](....
25 4NE0 - SIN C4 H6 O4 C(CC(=O)O)....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: OKG; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 OKG 1 1
2 SIN 0.454545 0.7
Similar Ligands (3D)
Ligand no: 1; Ligand: OKG; Similar ligands found: 591
No: Ligand Similarity coefficient
1 URP 0.9748
2 AKG 0.9746
3 FUM 0.9732
4 MAE 0.9721
5 S2G 0.9690
6 OGA 0.9668
7 MUC 0.9647
8 GLY GLY 0.9644
9 HBA 0.9639
10 2HG 0.9632
11 GUA 0.9621
12 9J3 0.9619
13 GLU 0.9615
14 NF3 0.9614
15 DE5 0.9603
16 GLN 0.9595
17 DGN 0.9594
18 HX2 0.9591
19 DQY 0.9591
20 OAA 0.9541
21 NMG 0.9540
22 2IT 0.9522
23 4MV 0.9517
24 G3P 0.9513
25 0VT 0.9506
26 DAV 0.9502
27 SHO 0.9496
28 SHF 0.9494
29 4VP 0.9493
30 13P 0.9483
31 URO 0.9483
32 ASP 0.9480
33 HDA 0.9473
34 BHH 0.9466
35 ZGL 0.9463
36 MLT 0.9453
37 DGL 0.9443
38 6NA 0.9440
39 LTL 0.9436
40 CRN 0.9430
41 H95 0.9421
42 OEG 0.9419
43 AL0 0.9416
44 9X6 0.9415
45 MEQ 0.9400
46 XRG 0.9395
47 EOU 0.9391
48 HTX 0.9389
49 PHB 0.9388
50 PGA 0.9388
51 URQ 0.9385
52 PGH 0.9379
53 ROR 0.9377
54 IOM 0.9373
55 PZM 0.9366
56 LMR 0.9364
57 UGC 0.9362
58 ASN 0.9358
59 SD4 0.9354
60 HSO 0.9350
61 HIS 0.9350
62 OK7 0.9348
63 PAB 0.9347
64 NPO 0.9345
65 4JL 0.9334
66 VKC 0.9334
67 DAS 0.9323
68 AC6 0.9319
69 TYL 0.9316
70 X1S 0.9310
71 GP9 0.9308
72 G3H 0.9302
73 XUL 0.9300
74 98J 0.9296
75 TEO 0.9293
76 R9M 0.9292
77 9ON 0.9289
78 PG3 0.9289
79 PAC 0.9286
80 N6C 0.9285
81 6JN 0.9284
82 HL5 0.9279
83 HSE 0.9276
84 FBJ 0.9274
85 7BC 0.9272
86 49F 0.9271
87 TZL 0.9270
88 ZBT 0.9267
89 650 0.9267
90 9X7 0.9266
91 GGL 0.9263
92 ONL 0.9261
93 1Y6 0.9259
94 EHM 0.9258
95 7WG 0.9256
96 ITN 0.9255
97 XLS 0.9254
98 TLA 0.9254
99 P72 0.9252
100 PEP 0.9248
101 DZA 0.9245
102 XYL 0.9244
103 129 0.9243
104 BP9 0.9240
105 NXA 0.9232
106 ISZ 0.9231
107 4MA 0.9230
108 SRT 0.9230
109 PBZ 0.9229
110 IXW 0.9227
111 1GP 0.9226
112 HSM 0.9224
113 9YL 0.9224
114 HPN 0.9223
115 XBT 0.9223
116 COI 0.9222
117 4FA 0.9220
118 HYA 0.9217
119 3OM 0.9210
120 K6H 0.9210
121 TAR 0.9206
122 PIM 0.9205
123 ORN 0.9203
124 Z82 0.9194
125 8EW 0.9194
126 RBL 0.9193
127 HG3 0.9192
128 GJZ 0.9191
129 J9N 0.9190
130 CFI 0.9189
131 HPV 0.9188
132 HBD 0.9187
133 3SL 0.9186
134 TCA 0.9184
135 717 0.9182
136 4SD 0.9178
137 XIZ 0.9175
138 4LR 0.9175
139 LNO 0.9172
140 FBM 0.9172
141 DYA 0.9171
142 MSR 0.9169
143 NLE 0.9169
144 LEA 0.9167
145 7OD 0.9166
146 LEU 0.9166
147 JYD 0.9163
148 ABU 0.9162
149 PAH 0.9160
150 PHU 0.9159
151 PIY 0.9159
152 PO6 0.9157
153 BHO 0.9157
154 SHV 0.9155
155 HIO 0.9155
156 5XA 0.9154
157 3PG 0.9153
158 K34 0.9152
159 16D 0.9151
160 GOJ 0.9150
161 NTU 0.9150
162 RSO 0.9149
163 PG0 0.9148
164 ANN 0.9147
165 3LR 0.9147
166 6PC 0.9144
167 M45 0.9144
168 YRL 0.9137
169 BEZ 0.9135
170 QY9 0.9132
171 OHG 0.9131
172 HE2 0.9130
173 ACA 0.9128
174 AG2 0.9128
175 I1E 0.9125
176 LYS 0.9124
177 FQI 0.9124
178 YIV 0.9122
179 MED 0.9122
180 4WL 0.9121
181 40E 0.9120
182 SPA 0.9119
183 5FX 0.9118
184 4ZA 0.9115
185 NIZ 0.9114
186 54D 0.9113
187 GPJ 0.9112
188 TIU 0.9111
189 HHI 0.9110
190 SNU 0.9110
191 MRY 0.9109
192 PNZ 0.9107
193 SSN 0.9106
194 HP6 0.9102
195 RNS 0.9101
196 2CO 0.9101
197 3PP 0.9100
198 1SA 0.9100
199 K6V 0.9098
200 CPZ 0.9095
201 PRA 0.9094
202 SEP 0.9092
203 BEN 0.9092
204 S8V 0.9091
205 DAL DAL 0.9090
206 SPV 0.9089
207 NCA 0.9089
208 14J 0.9088
209 BAM 0.9086
210 CXF 0.9084
211 KQY 0.9083
212 GAB 0.9083
213 ACH 0.9082
214 CCU 0.9082
215 OVV 0.9079
216 PSE 0.9077
217 CHH 0.9076
218 7A8 0.9076
219 2RH 0.9075
220 SME 0.9075
221 F9P 0.9075
222 DYT 0.9072
223 ICF 0.9070
224 3YP 0.9067
225 E5X 0.9066
226 NIO 0.9066
227 PEL 0.9065
228 4P5 0.9065
229 8OZ 0.9062
230 TZF 0.9060
231 FAN 0.9060
232 CEE 0.9058
233 GPF 0.9058
234 7C3 0.9056
235 QDK 0.9056
236 173 0.9055
237 F4E 0.9053
238 M6W 0.9052
239 BUB 0.9051
240 TPA 0.9050
241 HL4 0.9050
242 SGL 0.9049
243 JZ5 0.9049
244 PKU 0.9047
245 PBC 0.9045
246 6XA 0.9045
247 3OL 0.9044
248 BPN 0.9044
249 1DV 0.9043
250 174 0.9039
251 SN4 0.9039
252 MHN 0.9039
253 O8Y 0.9038
254 XIY 0.9038
255 M4T 0.9037
256 LER 0.9036
257 HX4 0.9034
258 CCD 0.9031
259 0L1 0.9031
260 3HG 0.9031
261 C1M 0.9029
262 PH3 0.9028
263 RB5 0.9028
264 1P3 0.9026
265 1P8 0.9025
266 J9T 0.9025
267 MET 0.9025
268 GLY ALA 0.9024
269 CXP 0.9023
270 HDH 0.9023
271 KMH 0.9021
272 HCI 0.9021
273 FK8 0.9018
274 MZT 0.9013
275 RMN 0.9012
276 826 0.9010
277 4NC 0.9010
278 PZI 0.9007
279 7N0 0.9003
280 SW7 0.9002
281 PEA 0.9002
282 3HB 0.9000
283 CYX 0.8998
284 2EH 0.8997
285 4NM 0.8997
286 A8C 0.8995
287 268 0.8995
288 DLY 0.8995
289 BNL 0.8995
290 AOT 0.8993
291 OSE 0.8993
292 INO 0.8993
293 UNU 0.8992
294 QMP 0.8991
295 36Y 0.8990
296 AEF 0.8988
297 URS 0.8987
298 CCE 0.8986
299 PHE 0.8985
300 BZ3 0.8985
301 A5E 0.8985
302 DIR 0.8985
303 PPR 0.8984
304 AMH 0.8982
305 HQJ 0.8981
306 5XC 0.8976
307 BNF 0.8976
308 OCT 0.8974
309 5XB 0.8974
310 DHI 0.8973
311 MPV 0.8972
312 AT3 0.8971
313 3AB 0.8971
314 IWT 0.8970
315 1M2 0.8969
316 2FT 0.8968
317 7VP 0.8968
318 258 0.8967
319 NM3 0.8967
320 NYL 0.8967
321 93K 0.8967
322 PPY 0.8962
323 69O 0.8962
324 PUT 0.8961
325 FEH 0.8961
326 4LW 0.8958
327 H8N 0.8958
328 OPE 0.8958
329 IP8 0.8957
330 3BZ 0.8956
331 KMT 0.8955
332 FW5 0.8955
333 MYJ 0.8954
334 DHB 0.8953
335 FCR 0.8952
336 RNT 0.8948
337 2HO 0.8948
338 J0Z 0.8947
339 152 0.8946
340 MAH 0.8942
341 HY1 0.8942
342 L5V 0.8940
343 GRO 0.8940
344 RUJ 0.8939
345 AMS 0.8935
346 3S5 0.8934
347 4JT 0.8930
348 P9P 0.8929
349 ES2 0.8928
350 R2P 0.8927
351 R20 0.8927
352 RB0 0.8924
353 069 0.8922
354 NM2 0.8921
355 M3H 0.8921
356 MR1 0.8919
357 GVG 0.8917
358 B3U 0.8913
359 MSE 0.8913
360 TIH 0.8910
361 6NI 0.8907
362 HIC 0.8902
363 4JM 0.8901
364 4LV 0.8900
365 OOG 0.8899
366 1SH 0.8897
367 IHB 0.8895
368 XX2 0.8894
369 X1R 0.8891
370 GWM 0.8889
371 ESX 0.8888
372 ALA ALA 0.8887
373 MHO 0.8886
374 8GL 0.8886
375 9TW 0.8884
376 HGA 0.8882
377 FOC 0.8881
378 2BG 0.8881
379 45L 0.8881
380 TSU 0.8880
381 MEV 0.8880
382 LPK 0.8879
383 BZ2 0.8871
384 GZ3 0.8870
385 AOS 0.8870
386 RTK 0.8868
387 KVV 0.8868
388 OTR 0.8867
389 0BP 0.8867
390 SSB 0.8867
391 FBB 0.8867
392 AEG 0.8866
393 AX7 0.8865
394 5LA 0.8864
395 CHB 0.8864
396 I3E 0.8862
397 FUD 0.8860
398 271 0.8858
399 4J8 0.8858
400 ESP 0.8856
401 FBS 0.8855
402 I38 0.8853
403 M4S 0.8852
404 JAW 0.8852
405 1SP 0.8851
406 6NT 0.8851
407 M6H 0.8850
408 BHL 0.8849
409 SAN 0.8847
410 DPN 0.8846
411 ONH 0.8840
412 0HO 0.8840
413 4A3 0.8839
414 K2T 0.8837
415 JLZ 0.8837
416 NCT 0.8837
417 MPJ 0.8835
418 0HN 0.8832
419 5OB 0.8831
420 5NI 0.8830
421 94W 0.8829
422 266 0.8828
423 SOL 0.8827
424 1X4 0.8826
425 2ZM 0.8825
426 UN1 0.8824
427 8GC 0.8823
428 PSJ 0.8822
429 KDG 0.8821
430 1F1 0.8821
431 9GB 0.8821
432 3HM 0.8820
433 264 0.8819
434 GVM 0.8819
435 3NY 0.8817
436 LYN 0.8817
437 3MB 0.8816
438 F60 0.8816
439 TGX 0.8814
440 ICB 0.8813
441 2HU 0.8811
442 OVM 0.8811
443 Q9Z 0.8810
444 A20 0.8809
445 HFA 0.8808
446 AAS 0.8806
447 SYM 0.8806
448 14O 0.8805
449 N9J 0.8804
450 3QM 0.8802
451 7MU 0.8799
452 AHN 0.8797
453 ABV 0.8797
454 DHR 0.8796
455 SHI 0.8795
456 NMJ 0.8795
457 8WO 0.8793
458 HPS 0.8790
459 FHB 0.8788
460 B40 0.8788
461 HC4 0.8788
462 NNO 0.8784
463 B85 0.8778
464 7UC 0.8777
465 S2P 0.8776
466 11S 0.8775
467 5H1 0.8775
468 F9Y 0.8773
469 A29 0.8773
470 K7M 0.8773
471 ET2 0.8773
472 3A9 0.8768
473 HF2 0.8767
474 I4B 0.8766
475 J9Q 0.8765
476 2F6 0.8763
477 2MI 0.8762
478 HBU 0.8758
479 4HA 0.8755
480 3SS 0.8755
481 JZ7 0.8755
482 ABI 0.8754
483 2K4 0.8753
484 GLO 0.8752
485 AC0 0.8751
486 P80 0.8750
487 PE9 0.8746
488 1L5 0.8746
489 4JQ 0.8746
490 5WZ 0.8746
491 259 0.8744
492 NMH 0.8744
493 SOR 0.8740
494 AML 0.8740
495 4JC 0.8740
496 6TZ 0.8739
497 2HC 0.8734
498 CLW 0.8730
499 OW4 0.8729
500 1CO 0.8729
501 5MI 0.8728
502 N4B 0.8727
503 3BU 0.8727
504 8K2 0.8726
505 1Z6 0.8725
506 O45 0.8725
507 E4P 0.8724
508 ETX 0.8721
509 MLZ 0.8720
510 NFA 0.8720
511 CWJ 0.8717
512 RAT 0.8717
513 KTJ 0.8715
514 PC 0.8715
515 SNO 0.8712
516 NBN 0.8711
517 FK1 0.8710
518 H4N 0.8702
519 SYC 0.8702
520 N2I 0.8701
521 KBZ 0.8701
522 52C 0.8699
523 97T 0.8699
524 JDN 0.8697
525 LT1 0.8696
526 RUY 0.8695
527 4NB 0.8694
528 RNO 0.8692
529 JB8 0.8691
530 GCO 0.8687
531 R67 0.8686
532 A3M 0.8685
533 DHM 0.8685
534 TAG 0.8684
535 LNR 0.8684
536 N2Z 0.8683
537 64Z 0.8683
538 LFC 0.8681
539 BCU 0.8679
540 IFP 0.8675
541 J6W 0.8674
542 2BX 0.8673
543 4YO 0.8672
544 92G 0.8669
545 MQN 0.8669
546 LUQ 0.8669
547 36R 0.8666
548 VGD 0.8665
549 WCE 0.8665
550 GLY CYS 0.8659
551 7O4 0.8658
552 YZM 0.8658
553 MTL 0.8656
554 JFJ 0.8656
555 L14 0.8655
556 FOM 0.8652
557 JF6 0.8652
558 CH9 0.8652
559 L22 0.8650
560 4FS 0.8649
561 5VM 0.8649
562 P81 0.8648
563 6FZ 0.8647
564 DAB 0.8644
565 0TU 0.8642
566 1KA 0.8641
567 COU 0.8637
568 8NY 0.8636
569 NSD 0.8635
570 LQ2 0.8633
571 MD0 0.8626
572 4PN 0.8621
573 03V 0.8615
574 OVP 0.8614
575 X0V 0.8609
576 EKZ 0.8606
577 XDK 0.8604
578 4V2 0.8590
579 OCH 0.8586
580 2AQ 0.8585
581 NLP 0.8571
582 GVY 0.8569
583 ES5 0.8561
584 4FH 0.8558
585 5HN 0.8558
586 4SX 0.8554
587 DTT 0.8554
588 9SE 0.8548
589 YPN 0.8546
590 P7Y 0.8532
591 BRT 0.8523
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2WBQ; Ligand: ZZU; Similar sites found with APoc: 15
This union binding pocket(no: 1) in the query (biounit: 2wbq.bio1) has 29 residues
No: Leader PDB Ligand Sequence Similarity
1 1NX4 AKG 5.66802
2 1NX4 AKG 5.66802
3 1NX4 AKG 5.66802
4 4OJ8 AKG 5.92885
5 6F6J CUW 37.1508
6 6F6J SIN 37.1508
7 6F6J CUW 37.1508
8 6F6J SIN 37.1508
9 6F6J SIN 37.1508
10 6F6J CUW 37.1508
11 6F6J SIN 37.1508
12 6EXF LYS 38.2682
13 1DRY AAG 39.6648
14 1DRY AKG 39.6648
15 2OG7 SIN 40.056
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