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Receptor
PDB id Resolution Class Description Source Keywords
6C1S 2.31 Å EC: 2.7.1.153 PHOSPHOINOSITIDE 3-KINASE GAMMA BOUND TO AN PYRROLOPYRIDINON INHIBITOR HOMO SAPIENS KINASE INHIBITOR TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DESIGN AND SYNTHESIS OF A NOVEL SERIES OF ORALLY BIOAVAILABLE, CNS-PENETRANT, ISOFORM SELECTIVE PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K GAMMA ) INHIB WITH POTENTIAL FOR THE TREATMENT OF MULTIPLE SCLERO J. MED. CHEM. V. 61 5245 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 A:1204;
A:1202;
A:1205;
A:1203;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
EFV A:1201;
Valid;
none;
Ki = 0.004 uM
376.369 C19 H16 N6 O3 COc1c...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6C1S 2.31 Å EC: 2.7.1.153 PHOSPHOINOSITIDE 3-KINASE GAMMA BOUND TO AN PYRROLOPYRIDINON INHIBITOR HOMO SAPIENS KINASE INHIBITOR TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: DESIGN AND SYNTHESIS OF A NOVEL SERIES OF ORALLY BIOAVAILABLE, CNS-PENETRANT, ISOFORM SELECTIVE PHOSPHOINOSITIDE 3-KINASE GAMMA (PI3K GAMMA ) INHIB WITH POTENTIAL FOR THE TREATMENT OF MULTIPLE SCLERO J. MED. CHEM. V. 61 5245 2018
Members (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 4FUL - 0VU C22 H23 N5 O3 S c1cc(cc(c1....
2 4ANW ic50 = 18 nM O92 C18 H14 Cl F2 N5 O3 S CNC(=O)c1c....
3 4WWP ic50 = 0.12 uM 3VE C22 H18 Cl N7 Cc1c(cccn1....
4 6AUD - BWY C25 H34 N6 O2 S CC(C)n1c(n....
5 4ANV ic50 = 441 nM 751 C28 H28 N4 O4 S COc1ccc(cc....
6 5JHB Kd = 873 nM 6K5 C18 H21 Cl F3 N7 O2 c1c(c(cnc1....
7 5G55 - 3QH C20 H18 N4 O Cc1ccc(cc1....
8 1E7V - LY2 C19 H17 N O3 c1ccc(cc1)....
9 2CHX - 090 C18 H16 N5 O3 COc1ccc2c(....
10 4WWO ic50 = 0.038 uM 3VD C22 H16 Cl F N6 C[C@@H](c1....
11 1E8Z - STU C28 H26 N4 O3 C[C@@]12[C....
12 3R7Q ic50 = 0.108 uM FAV C19 H14 Cl N O2 S CN(c1ccccc....
13 4GB9 - 0WR C28 H39 N9 O2 CC(C)(C1CC....
14 3ENE Ki = 0.57 uM NPZ C16 H13 N5 Cn1c2c(c(n....
15 3LJ3 ic50 = 43 nM WYE C22 H22 N4 O4 Cn1cc(c2c1....
16 2V4L ic50 = 1.5 uM ABJ C14 H15 N5 O CC(C)n1c2c....
17 6C1S Ki = 0.004 uM EFV C19 H16 N6 O3 COc1cc(cnc....
18 4HVB - 19P C24 H26 N6 O3 Cc1ccc(cn1....
19 1E8W - QUE C15 H10 O7 c1cc(c(cc1....
20 1E8X - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
21 3ZVV ic50 = 915 uM XAZ C8 H10 N4 Cc1cc(n2c(....
70% Homology Family (21)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 4 families.
1 4FUL - 0VU C22 H23 N5 O3 S c1cc(cc(c1....
2 4ANW ic50 = 18 nM O92 C18 H14 Cl F2 N5 O3 S CNC(=O)c1c....
3 4WWP ic50 = 0.12 uM 3VE C22 H18 Cl N7 Cc1c(cccn1....
4 6AUD - BWY C25 H34 N6 O2 S CC(C)n1c(n....
5 4ANV ic50 = 441 nM 751 C28 H28 N4 O4 S COc1ccc(cc....
6 5JHB Kd = 873 nM 6K5 C18 H21 Cl F3 N7 O2 c1c(c(cnc1....
7 5G55 - 3QH C20 H18 N4 O Cc1ccc(cc1....
8 1E7V - LY2 C19 H17 N O3 c1ccc(cc1)....
9 2CHX - 090 C18 H16 N5 O3 COc1ccc2c(....
10 4WWO ic50 = 0.038 uM 3VD C22 H16 Cl F N6 C[C@@H](c1....
11 1E8Z - STU C28 H26 N4 O3 C[C@@]12[C....
12 3R7Q ic50 = 0.108 uM FAV C19 H14 Cl N O2 S CN(c1ccccc....
13 4GB9 - 0WR C28 H39 N9 O2 CC(C)(C1CC....
14 3ENE Ki = 0.57 uM NPZ C16 H13 N5 Cn1c2c(c(n....
15 3LJ3 ic50 = 43 nM WYE C22 H22 N4 O4 Cn1cc(c2c1....
16 2V4L ic50 = 1.5 uM ABJ C14 H15 N5 O CC(C)n1c2c....
17 6C1S Ki = 0.004 uM EFV C19 H16 N6 O3 COc1cc(cnc....
18 4HVB - 19P C24 H26 N6 O3 Cc1ccc(cn1....
19 1E8W - QUE C15 H10 O7 c1cc(c(cc1....
20 1E8X - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
21 3ZVV ic50 = 915 uM XAZ C8 H10 N4 Cc1cc(n2c(....
50% Homology Family (41)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 2WXP ic50 = 3 nM GD9 C23 H27 N7 O3 S2 CS(=O)(=O)....
2 2WXL ic50 = 4.6 nM ZS4 C19 H21 F2 N7 O2 c1ccc2c(c1....
3 2WXO ic50 = 90 nM ZZP C22 H19 F N4 O4 S COC1=CC(=C....
4 6Q74 - HKN C22 H24 N4 O4 S Cc1nc(cn1C....
5 5T2B ic50 = 5 nM 74O C19 H18 N8 Cn1c(nc(n1....
6 2WXF ic50 = 180 nM 039 C21 H15 Cl N6 O2 S COc1ccccc1....
7 6FTN ic50 = 200 nM E78 C20 H23 N3 O2 S Cc1cc(cc2c....
8 5NCZ ic50 = 0.79 nM 8TN C24 H25 N7 O S CC1=CSC2=C....
9 4XE0 ic50 = 19 nM 40L C22 H18 F N7 O CC[C@@H](C....
10 2X38 ic50 = 130 nM IC8 C22 H19 N7 O Cc1ccccc1N....
11 5AE9 Ki = 0.0794 nM OKO C24 H28 N6 O5 S C[C@@H]1CN....
12 5AE8 Ki = 0.126 nM VVX C26 H28 N6 O CC(C)N1CCN....
13 6Q73 - HKK C11 H13 Cl N2 O3 S CS(=O)(=O)....
14 5T2I ic50 = 2 nM 74J C20 H19 N9 O Cn1c(nc(n1....
15 2WXG ic50 = 0.7 nM ZZN C28 H22 F N7 O2 Cc1ccccc1N....
16 5NCY ic50 = 0.4 nM 8TK C21 H18 N6 O S CC1=CSC2=C....
17 6Q6Y - HKQ C17 H13 Cl N2 O2 S c1ccc(cc1)....
18 4FUL - 0VU C22 H23 N5 O3 S c1cc(cc(c1....
19 4ANW ic50 = 18 nM O92 C18 H14 Cl F2 N5 O3 S CNC(=O)c1c....
20 4WWP ic50 = 0.12 uM 3VE C22 H18 Cl N7 Cc1c(cccn1....
21 6AUD - BWY C25 H34 N6 O2 S CC(C)n1c(n....
22 4ANV ic50 = 441 nM 751 C28 H28 N4 O4 S COc1ccc(cc....
23 5JHB Kd = 873 nM 6K5 C18 H21 Cl F3 N7 O2 c1c(c(cnc1....
24 5G55 - 3QH C20 H18 N4 O Cc1ccc(cc1....
25 1E7V - LY2 C19 H17 N O3 c1ccc(cc1)....
26 2CHX - 090 C18 H16 N5 O3 COc1ccc2c(....
27 4WWO ic50 = 0.038 uM 3VD C22 H16 Cl F N6 C[C@@H](c1....
28 1E8Z - STU C28 H26 N4 O3 C[C@@]12[C....
29 3R7Q ic50 = 0.108 uM FAV C19 H14 Cl N O2 S CN(c1ccccc....
30 4GB9 - 0WR C28 H39 N9 O2 CC(C)(C1CC....
31 3ENE Ki = 0.57 uM NPZ C16 H13 N5 Cn1c2c(c(n....
32 3LJ3 ic50 = 43 nM WYE C22 H22 N4 O4 Cn1cc(c2c1....
33 2V4L ic50 = 1.5 uM ABJ C14 H15 N5 O CC(C)n1c2c....
34 6C1S Ki = 0.004 uM EFV C19 H16 N6 O3 COc1cc(cnc....
35 4HVB - 19P C24 H26 N6 O3 Cc1ccc(cn1....
36 1E8W - QUE C15 H10 O7 c1cc(c(cc1....
37 1E8X - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
38 3ZVV ic50 = 915 uM XAZ C8 H10 N4 Cc1cc(n2c(....
39 6EZ6 - C5Z C26 H30 N6 O4 CC(C)N1CCN....
40 5UBR - 85S C26 H30 N8 O2 CC(=O)N1CC....
41 5DXT Ki = 0.2 nM 5H5 C19 H22 N6 O3 C[C@@H](C(....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: EFV; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 EFV 1 1
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6C1S; Ligand: EFV; Similar sites found with APoc: 640
This union binding pocket(no: 1) in the query (biounit: 6c1s.bio1) has 34 residues
No: Leader PDB Ligand Sequence Similarity
1 4ZH7 FUC GAL NAG GAL FUC 0.736648
2 3UG4 AHR 0.992063
3 3KLL MAL 1.13285
4 5L2R MLA 1.15894
5 2CXG GLC GLC 1.16618
6 4FG8 ATP 1.26984
7 1U6R ADP 1.31579
8 2D24 XYS XYS 1.37615
9 2YAB AMP 1.38504
10 4RF7 ARG 1.39276
11 4FL3 ANP 1.41732
12 1CT9 GLN 1.44665
13 5WNL STU 1.46199
14 4GYI ADP 1.51134
15 5Y86 HRM 1.53061
16 3PN1 IVH 1.57233
17 4OCV ANP 1.58311
18 1PK8 ATP 1.65877
19 4RD0 GDP 1.68675
20 3ETH ATP 1.69014
21 5MW8 ATP 1.69851
22 4OAV ACP 1.71674
23 2I4O ATP 1.74672
24 2HGS ADP 1.75077
25 2YRX AMP 1.77384
26 4Y85 499 1.80723
27 2HK5 1BM 1.85185
28 4TVD BGC 1.85376
29 1IXE COA 1.85676
30 4ONA UW1 1.8595
31 5VLQ ANP 1.86757
32 1I7E IBS 1.88679
33 4P5Z Q7M 1.93906
34 3TTI KBI 1.93966
35 3N75 G4P 1.95804
36 2P69 PLP 1.96078
37 5OD2 GLC 1.96507
38 4EE7 PIS 1.97368
39 4YZC STU 1.97531
40 5CKW ANP 1.99557
41 1RE8 BD2 2
42 4BTV RB3 2.03488
43 3X01 AMP 2.03562
44 4ITH RCM 2.04082
45 3HMO STU 2.04678
46 4ZGP ADP 2.04778
47 3PP0 03Q 2.07101
48 2GU8 796 2.07715
49 5FXD H7Y 2.09125
50 4O1P ANP 2.09205
51 4WOE ADP 2.09497
52 5C9P FUC 2.09974
53 1QPR PPC 2.11268
54 3VOT ADP 2.11765
55 4GC1 MAN MAN 2.17391
56 3VRY B43 2.20264
57 1SDW IYT 2.2293
58 5N87 N66 2.23642
59 1AUX AGS 2.2508
60 2WQN ADP 2.25806
61 4DXD 9PC 2.27273
62 5NKB 8ZT 2.28758
63 3EPO MP5 2.28758
64 3ZW2 NAG GAL FUC 2.29885
65 3ZW2 GLA NAG GAL FUC 2.29885
66 4YMJ 4EJ 2.30263
67 3MF2 AMP 2.31214
68 5BV3 M7G 2.31884
69 4AZW ATP 2.33546
70 4WHZ 3NL 2.33766
71 5COU ATP 2.35294
72 3HZT J60 2.35546
73 5YF9 NIO 2.35988
74 4G17 0VN 2.42424
75 4IZY 1J2 2.43902
76 2Z9I GLY ALA THR VAL 2.46914
77 1T36 ADP 2.47168
78 5UIU 8CG 2.47678
79 3PTG 932 2.47934
80 6FYL 3NG 2.47934
81 5H9P TD2 2.53165
82 4NFE BEN 2.53165
83 4LOC OXM 2.53165
84 5TT6 ATP 2.53807
85 3C0G 3AM 2.5641
86 3V4S ATP 2.58398
87 1F9V ADP 2.59366
88 4ZS4 ATP 2.60586
89 5C3R AKG 2.62391
90 5C3R HMU 2.62391
91 2GVJ DGB 2.64766
92 4M8D 23J 2.6616
93 4Y0X ADP 2.66667
94 6GZD LCI 2.6738
95 4LHD GLY 2.67765
96 3WVR AMP 2.68456
97 3GC8 B45 2.7027
98 4I9B NAD 2.70793
99 6F3G CJN 2.71186
100 5EH0 5NW 2.71318
101 5EXK 5AD 2.71903
102 3T3Z 9PL 2.73109
103 5DMZ ADP 2.73973
104 3UIM ANP 2.76074
105 4JGP PYR 2.76498
106 5USZ SKE 2.76817
107 4LH7 1X8 2.78638
108 4WNP 3RJ 2.78746
109 1U59 STU 2.78746
110 2PZI AXX 2.79001
111 4UXL 5P8 2.79503
112 5MUA GAL 2.7972
113 5I35 ANP 2.79898
114 3WG3 A2G GAL NAG FUC 2.80899
115 5OMY 9YE 2.8133
116 1SGJ OAA 2.8169
117 1GSA ADP 2.8481
118 5JGA 6KC 2.85714
119 2X2M X2M 2.86624
120 5ODY 9SK 2.89855
121 2IO8 ADP 2.90792
122 3PDT ADP 2.90909
123 2XN3 ID8 2.91545
124 6BFN DL1 2.92398
125 6GW4 CHO 2.9316
126 3E8N ATP 2.93255
127 3E8N VRA 2.93255
128 4JR7 GNP 2.94118
129 4CYI ATP 2.96804
130 4CVC PQQ 2.97203
131 3JU6 ANP 2.97297
132 4B3J COA 2.97767
133 2F2U M77 2.98507
134 6GIN IR2 2.99003
135 2H8H H8H 2.99065
136 5HCY 60D 3.02115
137 2PUL ACP 3.02267
138 5ZTN CUR 3.0303
139 3PB9 1BN 3.0303
140 4H3P ANP 3.03867
141 4H3Q ANP 3.03867
142 5KJW 53C 3.0445
143 5BVE 4VG 3.04709
144 1GPM AMP 3.04762
145 3AKK ADP 3.07692
146 4U98 ACP 3.0837
147 5VZ0 ADP 3.0896
148 6GI2 8SW 3.0896
149 2G30 ALA ALA PHE 3.10078
150 5LI9 ACP 3.14286
151 3G5D 1N1 3.14685
152 1JJE BYS 3.15315
153 5H4S RAM 3.16901
154 4D4U FUC GAL NAG 3.1746
155 2GC0 PAN 3.19149
156 1I7L ATP 3.23625
157 1Q6O LG6 3.24074
158 4RDL FUC GAL NDG FUC 3.24675
159 3PE2 E1B 3.2641
160 5C1P ADP 3.26797
161 3KRL KRL 3.28358
162 2V9M CIT 3.28467
163 3SLS ANP 3.28947
164 1VJY 460 3.30033
165 2C49 ADN 3.31126
166 3VMG 9CA 3.31633
167 3UDG TMP 3.32226
168 1OFL NGK GCD 3.3264
169 2JLD AG1 3.33333
170 1CKM GTP 3.33333
171 1CKN GTP 3.33333
172 3ALN ANP 3.36391
173 3DRW AMP 3.37553
174 4FF8 14S 3.40557
175 1VRP ADP 3.41207
176 3B6R ADP 3.41207
177 4DFU QUE 3.41615
178 4XV1 904 3.42466
179 6CMJ F6J 3.42679
180 2QCS ANP 3.43643
181 5EOB 5QQ 3.44828
182 1EHI ADP 3.44828
183 4XCB AKG 3.44828
184 2RIO ADP 3.45622
185 2JAJ D20 3.46021
186 3K5I ADP 3.47395
187 5QIN J2V 3.48101
188 4YZN 4K5 3.48432
189 5C03 AGS 3.50877
190 5C5T AKG 3.50877
191 4WNK 453 3.51171
192 4F9U PBD 3.52564
193 3ORK AGS 3.53698
194 1Y57 MPZ 3.53982
195 1CM8 ANP 3.54223
196 4QMN DB8 3.54839
197 6FYV 3NG 3.56083
198 1IA9 ANP 3.57143
199 2ZL4 ALA ALA ALA ALA 3.57143
200 4AUA 4AU 3.58306
201 4Y93 746 3.58744
202 4CQE CQE 3.59712
203 3VSV XYS 3.60502
204 3EXS 5RP 3.61991
205 5W4W 9WG 3.62538
206 4KBA 1QM 3.62538
207 4OUC 5ID 3.64146
208 6G34 5ID 3.64146
209 2OJW ADP 3.64583
210 1M0W ANP 3.66599
211 4CLI 5P8 3.66972
212 6GNO XDI 3.7037
213 1NKI PPF 3.7037
214 4NM5 ADP 3.71353
215 4WB6 ATP 3.71429
216 5M4Q PRO 3.71901
217 3SXS PP2 3.73134
218 2Q7D ANP 3.75723
219 4EUU BX7 3.76176
220 4WOV 3SM 3.78549
221 1LNM DTX 3.80435
222 2AQX ATP 3.80623
223 5OKT 9XK 3.82166
224 4XGX ADP 3.82353
225 1JPA ANP 3.84615
226 4YGF AZM 3.84615
227 3RE4 TO1 3.87597
228 3A6T 8OG 3.87597
229 5O5Y GLC 3.87931
230 5KO1 6UY 3.88693
231 5HES 032 3.90879
232 4IJP 1EH 3.91061
233 4QTB 38Z 3.94737
234 1ZY5 ANP 3.9604
235 3LXK MI1 3.97554
236 5NFB 8VT 3.97727
237 5YK1 ANP 3.9823
238 3GGF GVD 3.98671
239 3F7Z 34O 4
240 1ULE GLA GAL NAG 4
241 2Z3U CRR 4
242 1O9U ADZ 4
243 3HAV ATP 4.01338
244 4NW6 2NS 4.02477
245 2XMY CDK 4.02685
246 1PHK ATP 4.02685
247 2BMB PMM 4.0367
248 5DEY 59T 4.0404
249 3WV6 GAL BGC 4.05405
250 4IPH 1FJ 4.06504
251 5TKJ ALA VAL GLY ILE GLY ALA VAL PHE 4.0724
252 3LXN MI1 4.08805
253 4RHS SIA SIA GAL 4.09836
254 2F57 23D 4.10095
255 5H2U 1N1 4.11985
256 5OES ADP 4.14079
257 6A1G 9OL 4.16667
258 6CZ3 FLJ 4.16667
259 5TA6 79D 4.18994
260 2QK4 ATP 4.20354
261 4AVB CMP 4.2042
262 4BG4 ADP 4.21348
263 4I6H 1C8 4.22078
264 4OCJ NDG 4.22164
265 5GLT BGC GAL NAG GAL 4.22535
266 3NW7 LGV 4.23453
267 3GC0 AMP 4.25532
268 1Q8Y ADE 4.28954
269 1Q8Y ADP 4.28954
270 4GJ3 0XP 4.30464
271 2OFV 242 4.33213
272 1K3A ACP 4.34783
273 1LSH PLD 4.38871
274 4PU5 ANP 4.41501
275 5FPX GLY SER SER HIS HIS HIS HIS HIS 4.42478
276 5XVG 8FX 4.43686
277 4KS7 X4Z 4.45205
278 3F5A SIA GAL NAG 4.47154
279 3FC2 IBI 4.47761
280 5JSP DQY 4.47761
281 5VCV 1N1 4.50161
282 1I7A PHE 4.5045
283 6BXI ANP 4.5045
284 3ZXE PGZ 4.51128
285 3FHI ANP 4.54545
286 6GVZ CHO 4.59016
287 6AC9 ANP 4.59459
288 5GMD AMP 4.61538
289 3ANY 2A3 4.63576
290 5WO4 B7V 4.63576
291 4I94 ANP 4.66667
292 4AT3 LTI 4.68227
293 5MY8 RXZ 4.69974
294 6EAC ANP 4.71311
295 1KGI T4A 4.72441
296 1J3R 6PG 4.73684
297 5EQY 5RA 4.73815
298 5OCG 9R5 4.7619
299 5FIT AP2 4.7619
300 2WBV SIA 4.7619
301 4LO2 GAL BGC 4.7619
302 4E93 GUI 4.77454
303 4DS8 A8S 4.78469
304 5MN0 A8S 4.78469
305 2Y6O 1N1 4.811
306 4D1J DGJ 4.81482
307 2B9F ADP 4.81586
308 2B9H ADP 4.81586
309 2B9I ADP 4.81586
310 2B9J ADP 4.81586
311 2GTE VA 4.83871
312 1I1E DM2 4.84037
313 5CPR 539 4.85075
314 3ZGJ RMN 4.85175
315 6CGD GNP 4.91803
316 6CGD AKN 4.91803
317 3IGO ANP 4.93827
318 4Z87 GDP 4.95238
319 3SAO DBH 5
320 3SAO NKN 5
321 1CBK ROI 5
322 5JDA AMP 5.01393
323 4MNS 2AX 5.03145
324 5M06 ADP 5.07246
325 5U6C 7YS 5.07937
326 3TXO 07U 5.09915
327 3Q60 ATP 5.12129
328 4TWP AXI 5.16605
329 5FBN 5WF 5.16605
330 4PNI KQQ 5.16934
331 3T4L ZEA 5.18518
332 2YKL NLD 5.18868
333 6FA4 D1W 5.20231
334 1Z0N BCD 5.20833
335 3MTW M3R 5.21092
336 1OBD ATP 5.22876
337 2PYW ADP 5.2381
338 3FW3 GLC 5.26316
339 3JRS A8S 5.28846
340 3OJI PYV 5.29101
341 5IGI GMP 5.31561
342 2BKK ADP 5.32544
343 1UYY BGC BGC 5.34351
344 2FUE M1P 5.34351
345 3SRV S19 5.41516
346 6E08 NAP 5.43689
347 4CSV STI 5.45455
348 2Z48 NGA 5.45829
349 2YNE NHW 5.46875
350 2YNE YNE 5.46875
351 4F4P 0SB 5.49451
352 4R78 AMP 5.50162
353 2IF8 ADP 5.50964
354 5V3D FCN 5.51724
355 4ZU5 THM 5.55556
356 3SCH TB6 5.55556
357 4OTH DRN 5.57185
358 4YEF 4CQ 5.61798
359 1S68 AMP 5.62249
360 3KYF 5GP 5GP 5.62771
361 4H6B 10X 5.64103
362 4H6B 10Y 5.64103
363 4K55 H6P 5.64516
364 4XJ6 GH3 5.65111
365 3A76 SPD 5.68182
366 6F5W KG1 5.69106
367 6E1Q CFA 5.71429
368 4L9I 8PR 5.75397
369 3TII ANP 5.78947
370 6GQM F8H 5.79268
371 4JH6 FCN 5.7971
372 4YBN FAD 5.80357
373 1ZTH ADP 5.81395
374 1ZP9 ATP 5.81395
375 6EOM ALA LYS 5.83039
376 1E4E ADP 5.8309
377 5AWM ANP 5.83756
378 4IAW LIZ 5.85106
379 4UBS DIF 5.85242
380 3EKK GS2 5.86319
381 5VC5 96M 5.88235
382 5TPV TYD 5.88235
383 2NV2 GLN 5.88235
384 4YLZ LAT NAG GAL 5.88235
385 6GUE FB8 5.97015
386 2PVF ACP 5.98802
387 2BPM 529 6.03774
388 2W5P CL8 6.04027
389 3VPD ANP 6.04982
390 5JZJ AN2 6.06061
391 5J75 6GQ 6.06061
392 3UDZ ADP 6.08519
393 4X7Q 3YR 6.08974
394 4F9C 0SX 6.09418
395 4BCQ TJF 6.10687
396 4BCN T9N 6.10687
397 4CFU 2WC 6.10687
398 4BCM T7Z 6.10687
399 1P0Z FLC 6.10687
400 2YW2 ATP 6.13208
401 4INI AMP 6.15385
402 3DGY 2GP 6.18557
403 4E1Z 0MX 6.18557
404 3I0O ADP 6.19469
405 1ZHS NAG NAG BMA MAN MAN 6.19469
406 5LMK 6ZK 6.20155
407 4UAL 3FV 6.20525
408 2Z7R STU 6.23053
409 4USF 6UI 6.25
410 5L8L ADP 6.31579
411 4UX9 ANP 6.31868
412 2VDF OCT 6.32411
413 6EWZ APC 6.32911
414 3V8S 0HD 6.34146
415 3VPC ADP 6.38298
416 1KJ1 MAN 6.42202
417 3RFA SAM 6.43564
418 4FOU C2E 6.43939
419 4FOJ C2E 6.43939
420 6E2O S0L 6.44068
421 5NLD LBT 6.47482
422 2C5S AMP 6.53753
423 1U5R ATP 6.6092
424 2R09 4IP 6.62824
425 5EW9 5VC 6.64207
426 5X8I SQZ 6.6474
427 4YEE 4CQ 6.66667
428 3RI1 3RH 6.70927
429 6CQF F97 6.73401
430 5TO8 7FM 6.73759
431 3RWP ABQ 6.75241
432 5LVP ATP 6.75241
433 4AU8 Z3R 6.75676
434 4K33 ACP 6.76923
435 6G33 5ID 6.78466
436 3TKI S25 6.81115
437 2PVN P63 6.81818
438 3THR C2F 6.82594
439 2HY0 306 6.8323
440 5VX9 FUC GAL NAG GAL BGC 6.8323
441 5DRB 5FJ 6.87285
442 4L3L 5FI 6.90789
443 1B4P GPS 6.91244
444 4MOB ADP 6.92771
445 4XH0 ADP 6.94789
446 5DH3 5BS 6.98413
447 4FK7 P34 6.9869
448 4MA6 28E 7.00637
449 3QRC SCR 7.00637
450 4IDT T28 7.02247
451 3GQI ACP 7.05521
452 5A6N U7E 7.06714
453 5UR1 YY9 7.07396
454 3KN5 ANP 7.07692
455 2HRL SIA GAL SIA BGC NGA CEQ 7.08661
456 1TQP ATP 7.0922
457 5TDF ADP 7.09877
458 4IX4 ADP 7.14286
459 5T8O 76Z 7.16332
460 3DLS ADP 7.16418
461 6D61 4AA 7.17949
462 5YJS SAL 7.17949
463 3GNI ATP 7.19794
464 4U44 3D9 7.22892
465 5LFV SIA GAL NAG 7.25552
466 3KDJ A8S 7.27848
467 2OG7 SIN 7.28291
468 2J7T 274 7.28477
469 5JOP GAL BGC NAG GAL 7.30594
470 2YAK OSV 7.36842
471 3OQJ 3CX 7.393
472 5JKG 6LF 7.3955
473 3FHR P4O 7.44048
474 5KEW 6SB 7.44681
475 3IDB ANP 7.45342
476 5IH9 6BF 7.46269
477 4BFM ANP 7.48503
478 4BHN BH9 7.48503
479 2P7Q GG6 7.5188
480 5FU3 BGC BGC BGC 7.54717
481 5UPK ANP 7.56757
482 5XQW 8EU 7.58294
483 1UF5 CDT 7.59076
484 1BHX ASP PHE GLU GLU ILE 7.61905
485 5B09 4MX 7.69231
486 2BS5 BGC GAL FUC 7.77778
487 4BT5 23B 7.7821
488 5AX9 4KT 7.79221
489 3LXI CAM 7.83848
490 2X2T GAL NGA 7.84314
491 5EZU MYR 7.86517
492 5GZ9 ANP 7.86885
493 3ORQ ADP 7.95756
494 3AJ4 SEP 8.03571
495 6CZI 38E 8.03571
496 2CSN CKI 8.08081
497 3TDV GDP 8.16993
498 1RV1 IMZ 8.23529
499 4A4X JUP 8.24373
500 3H9R TAK 8.25688
501 4RFM 3P6 8.27068
502 3DAK ANP 8.27586
503 3W0O HY0 8.30946
504 3W0O ADP 8.30946
505 5KK4 44E 8.33333
506 2WEI VGG 8.36237
507 1XE7 GUN 8.37438
508 5LXT ACP 8.39161
509 4WB7 ATP 8.39506
510 5C4L 4XR 8.41121
511 4S1D 41M 8.41121
512 3SJK LYS PRO VAL LEU ARG THR ALA 8.42105
513 4Y24 TD2 8.44156
514 2ZQO NGA 8.46154
515 4XBA GMP 8.5
516 4XBA 5GP 8.5
517 5MJA 7O3 8.52459
518 2VFT SOR 8.53081
519 4BTK DTQ 8.60534
520 2XVD AS6 8.60927
521 4IXW IXW 8.66142
522 5WSY 7UC 8.67052
523 1KJ8 ATP 8.69565
524 4EWH T77 8.72727
525 2JDR L20 8.77193
526 2JDR GLY ARG PRO ARG THR THR SER PHE ALA GLU 8.77193
527 1IS3 LAT 8.88889
528 3T0W DIW 8.94309
529 5Y4R C2E 8.96552
530 3JQ3 ADP 9.01639
531 2ZV2 609 9.0604
532 4C2V YJA 9.09091
533 2XOC ADP 9.1954
534 2XOC ADE 9.1954
535 3KMW ATP 9.30233
536 4NFN 2KC 9.38511
537 3O0G 3O0 9.39597
538 6GU6 1QK 9.52381
539 5HQ0 LZ9 9.52381
540 1JBU BEN 9.52381
541 5G1X ADP 9.52381
542 4WW7 AMP 9.62567
543 3TY5 ATP 9.68523
544 3TY5 ADP 9.68523
545 3P7N FMN 9.68992
546 3M2W L8I 9.699
547 2WU6 DKI 9.71129
548 4OIT MAN 9.73451
549 1TZD ADP 9.81818
550 2QL9 CIT 9.82659
551 1ELI PYC 10.0257
552 5YW5 ADE 10.0559
553 3PLS ANP 10.0671
554 5ZCT ANP 10.1307
555 4K3H 1OM 10.1695
556 6F9G PUT 10.2804
557 2A19 ANP 10.2857
558 2R5T ANP 10.4558
559 2VZ6 FEF 10.5431
560 6FOF LAT 10.7143
561 4XZ3 ACP 10.8696
562 4XYM A12 10.8696
563 1W2D ADP 10.9434
564 2VN9 GVD 10.9635
565 4N70 2HX 10.9756
566 1XJD STU 11.0145
567 4OIC A8S 11.1111
568 1BYG STU 11.1511
569 1OUK 084 11.2022
570 3VV1 GAL FUC 11.25
571 5XLY C2E 11.2782
572 4LOO SB4 11.3573
573 1RGE 2GP 11.4583
574 3CY2 MB9 11.465
575 4NST ADP 11.5672
576 5EFQ ADP 11.5672
577 3DNT ATP 11.5909
578 3TPV ADE 11.5909
579 3OYW TDG 11.9403
580 3AQV TAK 11.9565
581 1PVC ILE SER GLU VAL 11.9601
582 1V0O INR 12.1528
583 1H2T GDP 7MG 12.1795
584 3MPB FRU 12.1951
585 4RYV ZEA 12.2581
586 4LRJ ANP 12.426
587 6BXL SAM 12.963
588 2V7O DRN 13.0952
589 4Q5H ANP 13.1579
590 3N1S 5GP 13.4454
591 1JE1 GMP 13.5593
592 4RJD TFP 13.6364
593 4URS C2E 13.8298
594 3VPB ADP 14.2857
595 4OH4 ANP 14.4144
596 1UNH IXM 14.4231
597 5LPZ ADP 14.4578
598 6C7Y ADP 14.5299
599 5TBM 79A 14.7826
600 4CQK PIO 14.8936
601 3H0L ADP 14.8936
602 6DZN AE3 15.0235
603 5N0L ILE 15.0943
604 4RT1 C2E 15.1786
605 3BZ3 YAM 15.2174
606 1C1L GAL BGC 15.3285
607 3LQV ADE 15.3846
608 1D1G MTX 15.4762
609 5Y80 IRE 15.5405
610 3ZRM ZRM 15.625
611 1Y2F WAI 15.8273
612 1N5S ADL 16.0714
613 2XK9 XK9 16.1491
614 5LPB ADP 16.2162
615 3PAK MAN 16.2162
616 1ECM TSA 16.5138
617 2BVE PH5 16.8067
618 5K2M ADP 16.9811
619 5ODT ADP 17.3913
620 2R0H CTO 17.6829
621 3E5A VX6 18.1818
622 4B1W LAB 18.75
623 4ASE AV9 19.2635
624 3PVW QRX 20.2703
625 6C0T EE4 21.0375
626 5LXM ADP 21.0526
627 6E2B PT7 21.0526
628 5YRV 5AD 21.1679
629 4Y8D 49J 21.4286
630 5UKL SIX 24.1935
631 1DCP HBI 25
632 4EBZ NAG NAG NAG NAG 26.4151
633 4DC2 ADE 28.5714
634 5MT9 SRO 28.5714
635 3MN5 LAB 28.9474
636 5EYK 5U5 30.5085
637 3BU5 ATP 33.3333
638 4C2W ANP 34.6154
639 4UWH JXM 35.4409
640 5LI1 ANP 40
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