Receptor
PDB id Resolution Class Description Source Keywords
6D2Z 1.18 Å EC: 3.1.4.- STRUCTURE OF HUMAN USB1 WITH URIDINE-ADENOSINE, INACTIVE H20 HOMO SAPIENS EXONUCLEASE U6 SNRNA 2H PHOSPHODIESTERASE SUPERFAMILY HYDHYDROLASE-RNA COMPLEX
Ref.: STRUCTURAL AND MECHANISTIC BASIS FOR PREFERENTIAL DEADENYLATION OF U6 SNRNA BY USB1. NUCLEIC ACIDS RES. V. 46 11488 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:301;
Invalid;
none;
submit data
35.453 Cl [Cl-]
U A C:1;
Valid;
Atoms found LESS than expected: % Diff = 0;
submit data
636.384 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6D30 1.17 Å EC: 3.1.4.- STRUCTURE OF HUMAN USB1 WITH URIDINE-URIDINE, INACTIVE H208Q HOMO SAPIENS EXONUCLEASE U6 SNRNA 2H PHOSPHODIESTERASE SUPERFAMILY HYDHYDROLASE-RNA COMPLEX
Ref.: STRUCTURAL AND MECHANISTIC BASIS FOR PREFERENTIAL DEADENYLATION OF U6 SNRNA BY USB1. NUCLEIC ACIDS RES. V. 46 11488 2018
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 11 families.
1 6D30 - U U n/a n/a
2 6D2Z - U A n/a n/a
3 6D31 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 6D30 - U U n/a n/a
2 6D2Z - U A n/a n/a
3 6D31 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 6D30 - U U n/a n/a
2 6D2Z - U A n/a n/a
3 6D31 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: U A ; Similar ligands found: 191
No: Ligand ECFP6 Tc MDL keys Tc
1 U A 1 1
2 U A A U 0.854701 1
3 A U 0.741379 0.960526
4 A U C C 0.707692 0.935897
5 A A 0.684685 0.933333
6 A G U U 0.673913 0.925
7 A G U 0.649635 0.925
8 U U 0.645455 0.88
9 UP5 0.644628 0.960526
10 4TC 0.634146 0.935897
11 UPA 0.634146 0.948052
12 U U U U 0.633027 0.866667
13 APU 0.616 0.960526
14 A C A C 0.590909 0.935897
15 U A C C 0.578947 0.948052
16 G A A A 0.568182 0.8875
17 139 0.557252 0.9125
18 A G 0.556391 0.898734
19 ATP A A A 0.552846 0.92
20 ATP A 0.552846 0.92
21 U A G G 0.552239 0.898734
22 G U 0.545455 0.9125
23 ADP MG 0.526786 0.906667
24 GAP 0.525862 0.884615
25 ADP BMA 0.512195 0.884615
26 ADP PO3 0.508621 0.906667
27 ATP MG 0.508621 0.906667
28 G G 0.507812 0.911392
29 G C C C 0.496552 0.936709
30 DAL AMP 0.491803 0.896104
31 UTP U U U 0.491667 0.826667
32 ALF ADP 0.491667 0.839506
33 ADP ALF 0.491667 0.839506
34 A 0.490909 0.906667
35 AMP 0.490909 0.906667
36 MYR AMP 0.488189 0.811765
37 ADP VO4 0.487603 0.896104
38 VO4 ADP 0.487603 0.896104
39 PUA 0.482517 0.924051
40 G G G C 0.482517 0.949367
41 4TA 0.478571 0.890244
42 ADP 0.478261 0.907895
43 SFB 0.477941 0.769231
44 45A 0.477876 0.858974
45 ABM 0.477876 0.858974
46 A2D 0.477876 0.907895
47 A A A 0.47619 0.871795
48 PRX 0.474576 0.8375
49 AN2 0.474138 0.896104
50 SRA 0.473214 0.860759
51 AGS 0.470588 0.8625
52 APC MG 0.470588 0.883117
53 SAP 0.470588 0.8625
54 A12 0.469565 0.873418
55 BA3 0.469565 0.907895
56 AP2 0.469565 0.873418
57 Z5A 0.469388 0.858824
58 APC G U 0.468531 0.851852
59 AP5 0.465517 0.907895
60 B4P 0.465517 0.907895
61 TYR AMP 0.462121 0.886076
62 AT4 0.461538 0.873418
63 ADQ 0.460317 0.884615
64 G3A 0.458647 0.8875
65 CA0 0.457627 0.884615
66 ADX 0.457627 0.8
67 AU1 0.457627 0.884615
68 M33 0.457627 0.871795
69 A22 0.456 0.921053
70 ATF 0.455285 0.873418
71 ARG AMP 0.455224 0.823529
72 G5P 0.455224 0.8875
73 ACP 0.453782 0.884615
74 HEJ 0.453782 0.907895
75 ATP 0.453782 0.907895
76 KG4 0.453782 0.884615
77 50T 0.453782 0.871795
78 5AS 0.452991 0.736264
79 25A 0.452381 0.933333
80 8LH 0.451613 0.873418
81 AMP DBH 0.451128 0.860759
82 T99 0.45082 0.873418
83 TAT 0.45082 0.873418
84 ANP 0.45082 0.884615
85 G C 0.450704 0.9125
86 5FA 0.45 0.907895
87 U2G 0.45 0.901235
88 AQP 0.45 0.907895
89 APC 0.45 0.873418
90 AR6 0.45 0.883117
91 APR 0.45 0.883117
92 NAJ PZO 0.448276 0.911392
93 HQG 0.448 0.896104
94 AD9 0.446281 0.884615
95 ADV 0.446281 0.85
96 RBY 0.446281 0.85
97 LPA AMP 0.445255 0.811765
98 AR6 AR6 0.444444 0.907895
99 PO4 PO4 A A A A PO4 0.44186 0.893333
100 9X8 0.44186 0.839506
101 5SV 0.440945 0.797619
102 4UV 0.440298 0.910256
103 A G C C 0.439189 0.924051
104 ACQ 0.439024 0.884615
105 TXE 0.438849 0.923077
106 LMS 0.438596 0.77907
107 PAJ 0.4375 0.831325
108 A3R 0.4375 0.829268
109 4AD 0.4375 0.886076
110 T5A 0.43662 0.879518
111 8LE 0.435484 0.8625
112 5AL 0.435484 0.896104
113 4UU 0.433824 0.910256
114 MAP 0.433071 0.8625
115 8LQ 0.433071 0.873418
116 UDP ALA FGA CYS DAL DAL MUB C C A9Z 0.433036 0.806452
117 A4P 0.432624 0.858824
118 25L 0.431818 0.921053
119 GTA 0.430657 0.878049
120 6YZ 0.428571 0.884615
121 9SN 0.428571 0.864198
122 AF3 ADP 3PG 0.428571 0.831325
123 SRP 0.428571 0.873418
124 AMP NAD 0.427586 0.921053
125 AHZ 0.427536 0.811765
126 PR8 0.427481 0.821429
127 NAJ PYZ 0.426667 0.86747
128 A1R 0.426357 0.829268
129 AMO 0.426357 0.873418
130 SON 0.425 0.897436
131 1ZZ 0.424242 0.811765
132 BIS 0.424242 0.851852
133 3OD 0.424242 0.884615
134 AHX 0.423077 0.841463
135 6V0 0.421429 0.911392
136 TXD 0.421429 0.898734
137 NAI 0.421429 0.923077
138 G G G RPC 0.42069 0.911392
139 A3P 0.420168 0.906667
140 OAD 0.419847 0.884615
141 OOB 0.418605 0.921053
142 8QN 0.418605 0.896104
143 9ZA 0.418605 0.875
144 OZV 0.418605 0.883117
145 9ZD 0.418605 0.875
146 UPU 0.418033 0.842105
147 NAD 0.417808 0.946667
148 WAQ 0.416667 0.851852
149 LAD 0.416667 0.831325
150 AP0 0.415493 0.8875
151 B5Y 0.414815 0.886076
152 C C C C 0.414062 0.846154
153 DU DU DU DU BRU DA DU 0.41358 0.835294
154 NB8 0.413534 0.841463
155 PTJ 0.413534 0.864198
156 JB6 0.413534 0.851852
157 FYA 0.413534 0.871795
158 7MD 0.413043 0.811765
159 DLL 0.412214 0.921053
160 00A 0.412214 0.875
161 A3D 0.412162 0.934211
162 XAH 0.411765 0.811765
163 PAX 0.411765 0.91358
164 NAX 0.411348 0.888889
165 4UW 0.411348 0.876543
166 PAP 0.41129 0.894737
167 U3P 0.410714 0.815789
168 UA3 0.410714 0.815789
169 CSV 0.410448 0.814815
170 CSQ 0.410448 0.814815
171 UDP UDP 0.410256 0.84
172 DQV 0.410072 0.921053
173 3UK 0.409091 0.909091
174 ADN 0.407407 0.766234
175 XYA 0.407407 0.766234
176 RAB 0.407407 0.766234
177 CTP C C C C 0.407143 0.844156
178 AOC 0.40678 0.792208
179 H1Q 0.406504 0.87013
180 B5V 0.406015 0.897436
181 3AM 0.405172 0.868421
182 B5M 0.404412 0.886076
183 ME8 0.402985 0.811765
184 TXA 0.402985 0.873418
185 AFH 0.402878 0.831325
186 UCG 0.402597 0.9
187 C C 0.401575 0.857143
188 DND 0.401408 0.922078
189 NXX 0.401408 0.922078
190 NAE 0.401316 0.910256
191 8X1 0.4 0.731183
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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