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Receptor
PDB id Resolution Class Description Source Keywords
6D2Z 1.18 Å EC: 3.1.4.- STRUCTURE OF HUMAN USB1 WITH URIDINE-ADENOSINE, INACTIVE H20 HOMO SAPIENS EXONUCLEASE U6 SNRNA 2H PHOSPHODIESTERASE SUPERFAMILY HYDHYDROLASE-RNA COMPLEX
Ref.: STRUCTURAL AND MECHANISTIC BASIS FOR PREFERENTIAL DEADENYLATION OF U6 SNRNA BY USB1. NUCLEIC ACIDS RES. V. 46 11488 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
CL A:301;
Invalid;
none;
submit data
35.453 Cl [Cl-]
U A C:1;
Valid;
Atoms found LESS than expected: % Diff = 0.023;
submit data
636.384 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6D30 1.17 Å EC: 3.1.4.- STRUCTURE OF HUMAN USB1 WITH URIDINE-URIDINE, INACTIVE H208Q HOMO SAPIENS EXONUCLEASE U6 SNRNA 2H PHOSPHODIESTERASE SUPERFAMILY HYDHYDROLASE-RNA COMPLEX
Ref.: STRUCTURAL AND MECHANISTIC BASIS FOR PREFERENTIAL DEADENYLATION OF U6 SNRNA BY USB1. NUCLEIC ACIDS RES. V. 46 11488 2018
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 9 families.
1 6D30 - U U n/a n/a
2 6D2Z - U A n/a n/a
3 6D31 - A C10 H14 N5 O7 P c1nc(c2c(n....
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 6D30 - U U n/a n/a
2 6D2Z - U A n/a n/a
3 6D31 - A C10 H14 N5 O7 P c1nc(c2c(n....
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 6D30 - U U n/a n/a
2 6D2Z - U A n/a n/a
3 6D31 - A C10 H14 N5 O7 P c1nc(c2c(n....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: U A ; Similar ligands found: 179
No: Ligand ECFP6 Tc MDL keys Tc
1 U A 1 1
2 U A A U 0.854701 1
3 A U 0.741379 0.960526
4 A U C C 0.707692 0.935897
5 A A 0.684685 0.933333
6 A G U U 0.673913 0.925
7 A G U 0.649635 0.925
8 U U 0.645455 0.88
9 UP5 0.644628 0.960526
10 4TC 0.634146 0.935897
11 UPA 0.634146 0.948052
12 U U U U 0.633027 0.866667
13 APU 0.616 0.960526
14 A C A C 0.590909 0.935897
15 U A C C 0.578947 0.948052
16 G A A A 0.568182 0.8875
17 139 0.557252 0.9125
18 A G 0.556391 0.898734
19 ATP A A A 0.552846 0.92
20 U A G G 0.552239 0.898734
21 G U 0.545455 0.9125
22 GAP 0.525862 0.884615
23 ADP BMA 0.512195 0.884615
24 ADP PO3 0.508621 0.906667
25 G G 0.507812 0.911392
26 G C C C 0.496552 0.936709
27 DAL AMP 0.491803 0.896104
28 UTP U U U 0.491667 0.826667
29 ADP ALF 0.491667 0.839506
30 ALF ADP 0.491667 0.839506
31 AMP 0.490909 0.906667
32 A 0.490909 0.906667
33 MYR AMP 0.488189 0.811765
34 ADP VO4 0.487603 0.896104
35 VO4 ADP 0.487603 0.896104
36 PUA 0.482517 0.924051
37 G G G C 0.482517 0.949367
38 4TA 0.478571 0.890244
39 ADP 0.478261 0.907895
40 SFB 0.477941 0.769231
41 ABM 0.477876 0.858974
42 A2D 0.477876 0.907895
43 A A A 0.47619 0.871795
44 PRX 0.474576 0.8375
45 AN2 0.474138 0.896104
46 SRA 0.473214 0.860759
47 SAP 0.470588 0.8625
48 AGS 0.470588 0.8625
49 BA3 0.469565 0.907895
50 AP2 0.469565 0.873418
51 A12 0.469565 0.873418
52 Z5A 0.469388 0.858824
53 APC G U 0.468531 0.851852
54 B4P 0.465517 0.907895
55 AP5 0.465517 0.907895
56 TYR AMP 0.462121 0.886076
57 AT4 0.461538 0.873418
58 ADQ 0.460317 0.884615
59 G3A 0.458647 0.8875
60 ADX 0.457627 0.8
61 M33 0.457627 0.871795
62 CA0 0.457627 0.884615
63 AU1 0.457627 0.884615
64 A22 0.456 0.921053
65 ATF 0.455285 0.873418
66 ARG AMP 0.455224 0.823529
67 G5P 0.455224 0.8875
68 ATP 0.453782 0.907895
69 HEJ 0.453782 0.907895
70 ACP 0.453782 0.884615
71 50T 0.453782 0.871795
72 5AS 0.452991 0.736264
73 25A 0.452381 0.933333
74 AMP DBH 0.451128 0.860759
75 TAT 0.45082 0.873418
76 T99 0.45082 0.873418
77 ANP 0.45082 0.884615
78 G C 0.450704 0.9125
79 U2G 0.45 0.901235
80 5FA 0.45 0.907895
81 APC 0.45 0.873418
82 APR 0.45 0.883117
83 AQP 0.45 0.907895
84 AR6 0.45 0.883117
85 NAJ PZO 0.448276 0.911392
86 AD9 0.446281 0.884615
87 ADV 0.446281 0.85
88 RBY 0.446281 0.85
89 LPA AMP 0.445255 0.811765
90 AR6 AR6 0.444444 0.907895
91 9X8 0.44186 0.839506
92 PO4 PO4 A A A A PO4 0.44186 0.893333
93 5SV 0.440945 0.797619
94 4UV 0.440298 0.910256
95 A G C C 0.439189 0.924051
96 ACQ 0.439024 0.884615
97 TXE 0.438849 0.923077
98 LMS 0.438596 0.77907
99 4AD 0.4375 0.886076
100 PAJ 0.4375 0.831325
101 A3R 0.4375 0.829268
102 T5A 0.43662 0.879518
103 5AL 0.435484 0.896104
104 4UU 0.433824 0.910256
105 MAP 0.433071 0.8625
106 UDP ALA FGA CYS DAL DAL MUB C C A9Z 0.433036 0.806452
107 A4P 0.432624 0.858824
108 25L 0.431818 0.921053
109 GTA 0.430657 0.878049
110 AF3 ADP 3PG 0.428571 0.831325
111 9SN 0.428571 0.864198
112 6YZ 0.428571 0.884615
113 SRP 0.428571 0.873418
114 AMP NAD 0.427586 0.921053
115 AHZ 0.427536 0.811765
116 PR8 0.427481 0.821429
117 NAJ PYZ 0.426667 0.86747
118 A1R 0.426357 0.829268
119 AMO 0.426357 0.873418
120 SON 0.425 0.897436
121 1ZZ 0.424242 0.811765
122 BIS 0.424242 0.851852
123 3OD 0.424242 0.884615
124 AHX 0.423077 0.841463
125 TXD 0.421429 0.898734
126 NAI 0.421429 0.923077
127 6V0 0.421429 0.911392
128 G G G RPC 0.42069 0.911392
129 A3P 0.420168 0.906667
130 OAD 0.419847 0.884615
131 8QN 0.418605 0.896104
132 OOB 0.418605 0.921053
133 9ZA 0.418605 0.875
134 9ZD 0.418605 0.875
135 UPU 0.418033 0.842105
136 NAD 0.417808 0.946667
137 LAD 0.416667 0.831325
138 WAQ 0.416667 0.851852
139 AP0 0.415493 0.8875
140 B5Y 0.414815 0.886076
141 C C C C 0.414062 0.846154
142 DU DU DU DU BRU DA DU 0.41358 0.835294
143 PTJ 0.413534 0.864198
144 NB8 0.413534 0.841463
145 FYA 0.413534 0.871795
146 JB6 0.413534 0.851852
147 7MD 0.413043 0.811765
148 DLL 0.412214 0.921053
149 00A 0.412214 0.875
150 A3D 0.412162 0.934211
151 PAX 0.411765 0.91358
152 XAH 0.411765 0.811765
153 4UW 0.411348 0.876543
154 NAX 0.411348 0.888889
155 PAP 0.41129 0.894737
156 UA3 0.410714 0.815789
157 U3P 0.410714 0.815789
158 CSQ 0.410448 0.814815
159 CSV 0.410448 0.814815
160 UDP UDP 0.410256 0.84
161 DQV 0.410072 0.921053
162 3UK 0.409091 0.909091
163 RAB 0.407407 0.766234
164 ADN 0.407407 0.766234
165 XYA 0.407407 0.766234
166 CTP C C C C 0.407143 0.844156
167 AOC 0.40678 0.792208
168 B5V 0.406015 0.897436
169 3AM 0.405172 0.868421
170 B5M 0.404412 0.886076
171 TXA 0.402985 0.873418
172 ME8 0.402985 0.811765
173 AFH 0.402878 0.831325
174 UCG 0.402597 0.9
175 C C 0.401575 0.857143
176 DND 0.401408 0.922078
177 NXX 0.401408 0.922078
178 NAE 0.401316 0.910256
179 8X1 0.4 0.731183
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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