Receptor
PDB id Resolution Class Description Source Keywords
6DO3 2.17 Å NON-ENZYME: OTHER KLHDC2 UBIQUITIN LIGASE IN COMPLEX WITH SELK C-END DEGRON HOMO SAPIENS KELCH REPEAT BETA-PROPELLER DEGRON COMPLEX SUBSTRATE RECE3 UBIQUITIN LIGASE LIGASE
Ref.: RECOGNITION OF THE DIGLYCINE C-END DEGRON BY CRL2KLHDC2UBIQUITIN LIGASE. MOL. CELL V. 72 813 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
PRO PRO PRO MET ALA GLY GLY C:85;
D:85;
 Valid;
Valid;
 none;
none;
 submit data
625.748 n/a S(CCC...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6DO3 2.17 Å NON-ENZYME: OTHER KLHDC2 UBIQUITIN LIGASE IN COMPLEX WITH SELK C-END DEGRON HOMO SAPIENS KELCH REPEAT BETA-PROPELLER DEGRON COMPLEX SUBSTRATE RECE3 UBIQUITIN LIGASE LIGASE
Ref.: RECOGNITION OF THE DIGLYCINE C-END DEGRON BY CRL2KLHDC2UBIQUITIN LIGASE. MOL. CELL V. 72 813 2018
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 6DO3 - PRO PRO PRO MET ALA GLY GLY n/a n/a
2 6DO5 - ILE GLY LEU LEU GLY GLY n/a n/a
3 6DO4 - GLY PRO SER SER GLY GLY n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 6DO3 - PRO PRO PRO MET ALA GLY GLY n/a n/a
2 6DO5 - ILE GLY LEU LEU GLY GLY n/a n/a
3 6DO4 - GLY PRO SER SER GLY GLY n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6DO3 - PRO PRO PRO MET ALA GLY GLY n/a n/a
2 6DO5 - ILE GLY LEU LEU GLY GLY n/a n/a
3 6DO4 - GLY PRO SER SER GLY GLY n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PRO PRO PRO MET ALA GLY GLY; Similar ligands found: 20
No: Ligand ECFP6 Tc MDL keys Tc
1 PRO PRO PRO MET ALA GLY GLY 1 1
2 PRO PRO GLY PRO ALA GLY PRO PRO GLY 0.508621 0.898305
3 PRO PRO PRO VAL PRO PRO ARG ARG ARG ARG 0.5 0.757576
4 PRO PRO PRO PRO PRO PRO PRO PRO PRO LEU 0.485714 0.833333
5 PRO PRO GLY PRO ARG GLY PRO PRO GLY 0.476562 0.784615
6 PRO PRO PRO PRO PRO PRO LEU PRO PRO 0.456897 0.833333
7 PRO PRO GLY PRO GLU GLY PRO PRO GLY 0.45082 0.864407
8 PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG 0.44697 0.85
9 PRO PRO GLY PRO PRO GLY PRO PRO GLY 0.444444 0.847458
10 PRO GLU ALA THR ALA PRO PRO GLU GLU 0.439394 0.84375
11 PRO PRO PRO VAL PRO PRO TYR SER ALA GLY 0.434783 0.8
12 PRO PRO LEU ALA SER LYS 0.421875 0.8
13 PRO LEU GLY GLY 0.417476 0.75
14 MET PRO PRO PRO PRO TPO PRO ARG SER 0.414634 0.710145
15 LEU PRO PRO GLU GLU ARG LEU ILE 0.408759 0.791045
16 MET PRO PRO PRO PRO SEP PRO CYS THR 0.408 0.724638
17 PRO PRO PRO VAL NMC PRO ARG ARG ARG 0.408 0.836066
18 PRO PRO LYS LYS LYS ARG LYS VAL 0.407692 0.742424
19 PRO PRO LYS ARG ILE ALA 0.405797 0.787879
20 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.40146 0.84375
Similar Ligands (3D)
Ligand no: 1; Ligand: PRO PRO PRO MET ALA GLY GLY; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6DO3; Ligand: PRO PRO PRO MET ALA GLY GLY; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6do3.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
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