Receptor
PDB id Resolution Class Description Source Keywords
6GH9 2.09 Å EC: 3.4.19.12 USP15 CATALYTIC DOMAIN IN COMPLEX WITH SMALL MOLECULE HOMO SAPIENS PROTEASE UBIQUITIN UBIQUITIN SPECIFIC PROTEASE INHIBITORMITOXANTRONE HYDROLASE
Ref.: THE STRUCTURE OF THE DEUBIQUITINASE USP15 REVEALS A MISALIGNED CATALYTIC TRIAD AND AN OPEN UBIQUITIN-BI CHANNEL. J. BIOL. CHEM. V. 293 17362 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DMS A:1002;
 Invalid;
 none;
 submit data
78.133 C2 H6 O S CS(=O...
MIX A:1003;
 Valid;
 none;
 submit data
444.481 C22 H28 N4 O6 c1cc(...
ZN A:1001;
 Part of Protein;
 none;
 submit data
65.409 Zn [Zn+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6GH9 2.09 Å EC: 3.4.19.12 USP15 CATALYTIC DOMAIN IN COMPLEX WITH SMALL MOLECULE HOMO SAPIENS PROTEASE UBIQUITIN UBIQUITIN SPECIFIC PROTEASE INHIBITORMITOXANTRONE HYDROLASE
Ref.: THE STRUCTURE OF THE DEUBIQUITINASE USP15 REVEALS A MISALIGNED CATALYTIC TRIAD AND AN OPEN UBIQUITIN-BI CHANNEL. J. BIOL. CHEM. V. 293 17362 2018
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 6GH9 - MIX C22 H28 N4 O6 c1cc(c2c(c....
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 6GH9 - MIX C22 H28 N4 O6 c1cc(c2c(c....
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 6GH9 - MIX C22 H28 N4 O6 c1cc(c2c(c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: MIX; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 MIX 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: MIX; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6GH9; Ligand: MIX; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6gh9.bio1) has 8 residues
No: Leader PDB Ligand Sequence Similarity
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