Receptor
PDB id Resolution Class Description Source Keywords
6GX6 2 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF IMP3 RRM12 IN COMPLEX WITH RNA (ACAC) HOMO SAPIENS RNA RECOGNITION MOTIF (RRM) IMP3 IGF2BP3 CRYSTAL STRUCTURBINDING PROTEIN
Ref.: STRUCTURAL BASIS OF IMP3 RRM12 RECOGNITION OF RNA. RNA V. 24 1659 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:203;
A:201;
A:204;
A:202;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
PO4 A:205;
Invalid;
none;
submit data
94.971 O4 P [O-]P...
A C A C B:1;
Valid;
Atoms found LESS than expected: % Diff = 0;
Kd = 4.7 uM
1203.8 n/a P(=O)...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6GX6 2 Å NON-ENZYME: BINDING CRYSTAL STRUCTURE OF IMP3 RRM12 IN COMPLEX WITH RNA (ACAC) HOMO SAPIENS RNA RECOGNITION MOTIF (RRM) IMP3 IGF2BP3 CRYSTAL STRUCTURBINDING PROTEIN
Ref.: STRUCTURAL BASIS OF IMP3 RRM12 RECOGNITION OF RNA. RNA V. 24 1659 2018
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 544 families.
1 6FQR Kd = 35 uM C C C C n/a n/a
2 6GX6 Kd = 4.7 uM A C A C n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 420 families.
1 6FQR Kd = 35 uM C C C C n/a n/a
2 6GX6 Kd = 4.7 uM A C A C n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 319 families.
1 6FQR Kd = 35 uM C C C C n/a n/a
2 6GX6 Kd = 4.7 uM A C A C n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: A C A C ; Similar ligands found: 117
No: Ligand ECFP6 Tc MDL keys Tc
1 A C A C 1 1
2 U A C C 0.926606 0.986842
3 A U C C 0.865546 1
4 A U 0.697479 0.973684
5 A G U U 0.686131 0.962025
6 U A A U 0.682171 0.935897
7 C C C C 0.675926 0.907895
8 A G U 0.661765 0.962025
9 A G C C 0.638462 0.936709
10 G C 0.634921 0.949367
11 C C 0.633027 0.894737
12 G C C C 0.619403 0.925
13 U A 0.590909 0.935897
14 A A 0.584746 0.871795
15 G G G C 0.58209 0.9375
16 G A A A 0.580153 0.924051
17 ATP A 0.578512 0.907895
18 ATP A A A 0.578512 0.907895
19 G G G RPC 0.548872 0.924051
20 U A G G 0.540741 0.911392
21 A A A 0.53719 0.860759
22 A G 0.533333 0.911392
23 APU 0.530303 0.923077
24 A3P 0.508929 0.846154
25 G U 0.5 0.949367
26 PAP 0.495726 0.835443
27 APC G U 0.489362 0.864198
28 3AM 0.481818 0.833333
29 PAX 0.479452 0.857143
30 0WD 0.478571 0.876543
31 CAR 0.477064 0.846154
32 C 0.477064 0.846154
33 C5P 0.477064 0.846154
34 GAP 0.475 0.897436
35 ADP MG 0.474138 0.894737
36 UP5 0.474074 0.923077
37 PPS 0.471074 0.75
38 4TC 0.467153 0.9
39 CDP 0.464912 0.835443
40 7XL 0.462185 0.8375
41 CTP C C C C 0.459259 0.857143
42 CSV 0.453846 0.85
43 CSQ 0.453846 0.85
44 ADP BMA 0.453125 0.897436
45 ATP MG 0.446281 0.894737
46 ADP PO3 0.446281 0.894737
47 UPA 0.446043 0.935897
48 2TM 0.445378 0.804878
49 MYR AMP 0.442748 0.802326
50 PUA 0.442177 0.865854
51 C3P 0.441441 0.833333
52 C5G 0.440945 0.860759
53 CTP 0.440678 0.835443
54 HF4 0.440678 0.835443
55 VO4 ADP 0.44 0.860759
56 ADP VO4 0.44 0.860759
57 A 0.438596 0.846154
58 AMP 0.438596 0.846154
59 CPA 0.435714 0.901235
60 DAL AMP 0.433071 0.884615
61 ADP ALF 0.432 0.829268
62 ALF ADP 0.432 0.829268
63 GPC 0.431507 0.880952
64 PO4 PO4 A A A A PO4 0.430769 0.881579
65 9BG 0.430556 0.876543
66 ADP 0.428571 0.848101
67 NMN AMP PO4 0.427586 0.923077
68 UDP ALA FGA CYS DAL DAL MUB C C A9Z 0.426667 0.817204
69 0RC 0.42623 0.817073
70 CDC 0.425197 0.761364
71 LQJ 0.422222 0.871795
72 A12 0.420168 0.817073
73 AP2 0.420168 0.817073
74 TYR AMP 0.419118 0.875
75 4TA 0.417808 0.879518
76 NAJ PYZ 0.417219 0.857143
77 C2G 0.416 0.848101
78 CXY 0.415385 0.8375
79 A2D 0.415254 0.871795
80 ABM 0.415254 0.825
81 45A 0.415254 0.825
82 PRX 0.414634 0.804878
83 AN2 0.413223 0.8375
84 NAI 0.411348 0.8875
85 APC MG 0.41129 0.871795
86 AGS 0.41129 0.807229
87 SAP 0.41129 0.807229
88 CTN 0.411215 0.779221
89 AR3 0.411215 0.779221
90 CDM 0.410853 0.797619
91 A22 0.410853 0.860759
92 SRA 0.410256 0.804878
93 NAJ PZO 0.409396 0.9
94 AMP DBH 0.408759 0.85
95 BA3 0.408333 0.871795
96 A2P 0.408333 0.833333
97 25A 0.407692 0.871795
98 ACP 0.406504 0.82716
99 ATP 0.406504 0.848101
100 HEJ 0.406504 0.848101
101 B4P 0.404959 0.871795
102 AP5 0.404959 0.871795
103 T99 0.404762 0.817073
104 TAT 0.404762 0.817073
105 LPA AMP 0.404255 0.802326
106 DG DA DC DG 0.403614 0.903614
107 AQP 0.403226 0.848101
108 APC 0.403226 0.817073
109 5FA 0.403226 0.848101
110 U U 0.403101 0.820513
111 ARG AMP 0.402878 0.857143
112 AR6 AR6 0.402878 0.896104
113 Z5A 0.402597 0.870588
114 AT4 0.401639 0.817073
115 SON 0.401639 0.839506
116 ATR 0.4 0.822785
117 7D5 0.4 0.790123
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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