Receptor
PDB id Resolution Class Description Source Keywords
6Y8B 1.54 Å EC: 2.7.11.1 14-3-3 SIGMA IN COMPLEX WITH PHOSPHORYLATED CASPASE{PS139} P HOMO SAPIENS 14-3-3 CASPASE{PS139} COMPLEX PROTEIN PROTEIN BINDING PPROTEIN INTERACTIONS
Ref.: A NEW SOAKING PROCEDURE FOR X-RAY CRYSTALLOGRAPHIC STRUCTURAL DETERMINATION OF PROTEIN-PEPTIDE COMPLEX ACTA CRYSTALLOGR.,SECT.F V. 76 501 2020
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG A:301;
A:303;
A:302;
 Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
 submit data
24.305 Mg [Mg+2...
TYR ASP LEU SEP LEU PRO PHE PRO P:136;
 Valid;
 Atoms found LESS than expected: % Diff = 0.014;
 submit data
1013.05 n/a P(=O)...
CL A:304;
 Invalid;
 none;
 submit data
35.453 Cl [Cl-]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6HHP 1.8 Å EC: 2.7.11.1 TERNARY COMPLEX OF ESTROGEN RECEPTOR ALPHA PEPTIDE AND 14-3- C42 MUTANT BOUND TO DISULFIDE FRAGMENT PPI STABILIZER 1 HOMO SAPIENS PROTEIN-PROTEIN INTERACTION FRAGMENT STABILIZER PROTEIN B
Ref.: SITE-DIRECTED FRAGMENT-BASED SCREENING FOR THE DISC PROTEIN-PROTEIN INTERACTION STABILIZERS. J. AM. CHEM. SOC. V. 141 3524 2019
Members (63)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 133 families.
1 6Y3W - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 O85 n/a n/a
2 6HKB - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
3 6FI5 Kd = 3 uM THR PRO SEP LEU PRO DAL 60H n/a n/a
4 5BTV Kd = 140 uM GLY SEP LEU GLY n/a n/a
5 6W0L - ALA ARG VAL SER MET ARG ARG MET SEP ASN n/a n/a
6 6XWD Kd = 2.18 uM ASN LYS ASN ALA ASN SEP SER PRO VAL n/a n/a
7 4Y32 ic50 = 90.1 uM ARG THR PRO SEP LEU PRO THR 49F n/a n/a
8 4Y5I ic50 = 301.3 uM ACE ARG THR PRO SEP LEU PRO THR PIP n/a n/a
9 6FBB - SER ARG SEP SER PRO n/a n/a
10 5N5W - 8OE C11 H8 Cl2 N2 O c1cc(ccc1N....
11 6FBY Kd = 9.3 uM ACE ARG THR PRO SEP LEU PRO GLY D4H n/a n/a
12 6Y3M - GLN SER TYR TPO VAL n/a n/a
13 6HHP Kd = 32 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
14 4DHS - Y03 C14 H12 Cl2 N O5 P c1ccc(c(c1....
15 6Y3S - ASN ALA ARG SER ALA SEP PHE SER GLN GLY n/a n/a
16 6GHP - ACE LYS ARG ARG LYS SEP VAL n/a n/a
17 4DHO - Y09 C15 H16 N O6 P COc1cccc(c....
18 6Y8A - ARG SER LEU SEP ALA PRO GLY ASN n/a n/a
19 6Y8E - ARG SER PHE SEP GLU PRO PHE GLY n/a n/a
20 3IQV Kd = 6.6 uM FSC C36 H56 O12 C[C@@H]1[C....
21 4IEA Kd = 346 nM ARG SER ALA SEP GLU PRO SER LEU n/a n/a
22 6HN2 - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
23 6Y58 Kd = 15.8 uM VAL TYR ARG SER LEU SEP PHE GLU n/a n/a
24 6FAW Kd = 2.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3K n/a n/a
25 5N75 - ARG SER HIS SEP SER PRO ALA SER LEU GLN n/a n/a
26 4DHN - 0KC C13 H18 N O5 P c1ccc(c(c1....
27 3MHR - ARG ALA HIS SEP SER PRO ALA SER LEU GLN n/a n/a
28 4DHP - Y07 C15 H12 Cl F3 N O5 P c1ccc(c(c1....
29 3LW1 Kd = 16.3 uM PHE LYS TPO GLU GLY PRO ASP SER ASP n/a n/a
30 3SP5 Kd = 0.56 uM LYS ARG ARG LYS SEP VAL n/a n/a
31 4DHU - 0KH C14 H12 Cl2 N O5 P c1ccc(c(c1....
32 6HMT Kd = 92 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
33 6Y1D - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 n/a n/a
34 6XY5 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O4E n/a n/a
35 3O8I - M1T C7 H14 O4 COCC(=O)CC....
36 6Y18 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O68 n/a n/a
37 6TJM - NE5 C24 H16 N2 O8 c1ccc(cc1)....
38 5OEH - 9SZ C42 H32 O8 P2 c1ccc2c(c1....
39 4DHT - 0KG C14 H20 N O5 P c1ccc(c(c1....
40 6HKF - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
41 6Y3O - ARG LYS LEU SEP LEU GLN GLU ARG n/a n/a
42 6Y8D - VAL GLU HIS SEP LEU ASP ASN LYS n/a n/a
43 5LU1 - ARG ARG ALA SEP ALA PRO LEU PRO n/a n/a
44 3IQJ Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
45 4FR3 Kd = 0.07 uM 0V4 C27 H44 O8 C[C@@H]1[C....
46 5HF3 Kd = 13.4 uM ACE ARG THR PRO SEP LEU PRO THR 60H n/a n/a
47 5N5R - NV1 C13 H20 N2 O Cc1cccc(c1....
48 4DHM - 0KB C15 H13 F3 N O5 P c1ccc(c(c1....
49 4DAT - SER SER PHE TYR PRO SEP ALA GLU GLY n/a n/a
50 6Y8B - TYR ASP LEU SEP LEU PRO PHE PRO n/a n/a
51 6FI4 Kd = 2.2 uM PRO SEP LEU PRO DVA 60H n/a n/a
52 3IQU - GLN ARG SER THR SEP THR n/a n/a
53 4DHQ - Y06 C14 H13 Cl N O5 P c1ccc(c(c1....
54 4DHR - Y04 C14 H13 Cl N O5 P c1ccc(c(c1....
55 4Y3B ic50 = 90.1 uM 49F C7 H15 N O COCC[C@@H]....
56 5N5T - SER HIS SEP SER PRO ALA SER LEU n/a n/a
57 6HMU - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
58 6XXC - LYS ARG ARG ARG LYS SEP CYS GLN ALA O3W n/a n/a
59 6FBW Kd = 16.5 uM ARG THR PRO SEP LEU PRO GLY D4K n/a n/a
60 6FAV Kd = 4.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3Q n/a n/a
61 5MXO - FSC C36 H56 O12 C[C@@H]1[C....
62 6TL3 - NJW C24 H17 N3 O7 c1ccc(cc1)....
63 6FAU Kd = 3.6 uM ACE ARG THR PRO SEP LEU PRO GLY D3W n/a n/a
70% Homology Family (79)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 101 families.
1 6Y3W - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 O85 n/a n/a
2 6HKB - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
3 6FI5 Kd = 3 uM THR PRO SEP LEU PRO DAL 60H n/a n/a
4 5BTV Kd = 140 uM GLY SEP LEU GLY n/a n/a
5 6W0L - ALA ARG VAL SER MET ARG ARG MET SEP ASN n/a n/a
6 6XWD Kd = 2.18 uM ASN LYS ASN ALA ASN SEP SER PRO VAL n/a n/a
7 4Y32 ic50 = 90.1 uM ARG THR PRO SEP LEU PRO THR 49F n/a n/a
8 4Y5I ic50 = 301.3 uM ACE ARG THR PRO SEP LEU PRO THR PIP n/a n/a
9 6FBB - SER ARG SEP SER PRO n/a n/a
10 5N5W - 8OE C11 H8 Cl2 N2 O c1cc(ccc1N....
11 6FBY Kd = 9.3 uM ACE ARG THR PRO SEP LEU PRO GLY D4H n/a n/a
12 6Y3M - GLN SER TYR TPO VAL n/a n/a
13 6HHP Kd = 32 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
14 4DHS - Y03 C14 H12 Cl2 N O5 P c1ccc(c(c1....
15 6Y3S - ASN ALA ARG SER ALA SEP PHE SER GLN GLY n/a n/a
16 6GHP - ACE LYS ARG ARG LYS SEP VAL n/a n/a
17 4DHO - Y09 C15 H16 N O6 P COc1cccc(c....
18 6Y8A - ARG SER LEU SEP ALA PRO GLY ASN n/a n/a
19 6Y8E - ARG SER PHE SEP GLU PRO PHE GLY n/a n/a
20 3IQV Kd = 6.6 uM FSC C36 H56 O12 C[C@@H]1[C....
21 4IEA Kd = 346 nM ARG SER ALA SEP GLU PRO SER LEU n/a n/a
22 6HN2 - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
23 6Y58 Kd = 15.8 uM VAL TYR ARG SER LEU SEP PHE GLU n/a n/a
24 6FAW Kd = 2.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3K n/a n/a
25 5N75 - ARG SER HIS SEP SER PRO ALA SER LEU GLN n/a n/a
26 4DHN - 0KC C13 H18 N O5 P c1ccc(c(c1....
27 3MHR - ARG ALA HIS SEP SER PRO ALA SER LEU GLN n/a n/a
28 4DHP - Y07 C15 H12 Cl F3 N O5 P c1ccc(c(c1....
29 3LW1 Kd = 16.3 uM PHE LYS TPO GLU GLY PRO ASP SER ASP n/a n/a
30 3SP5 Kd = 0.56 uM LYS ARG ARG LYS SEP VAL n/a n/a
31 4DHU - 0KH C14 H12 Cl2 N O5 P c1ccc(c(c1....
32 6HMT Kd = 92 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
33 6Y1D - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 n/a n/a
34 6XY5 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O4E n/a n/a
35 3O8I - M1T C7 H14 O4 COCC(=O)CC....
36 6Y18 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O68 n/a n/a
37 6TJM - NE5 C24 H16 N2 O8 c1ccc(cc1)....
38 5OEH - 9SZ C42 H32 O8 P2 c1ccc2c(c1....
39 4DHT - 0KG C14 H20 N O5 P c1ccc(c(c1....
40 6HKF - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
41 6Y3O - ARG LYS LEU SEP LEU GLN GLU ARG n/a n/a
42 6Y8D - VAL GLU HIS SEP LEU ASP ASN LYS n/a n/a
43 5LU1 - ARG ARG ALA SEP ALA PRO LEU PRO n/a n/a
44 3IQJ Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
45 4FR3 Kd = 0.07 uM 0V4 C27 H44 O8 C[C@@H]1[C....
46 5HF3 Kd = 13.4 uM ACE ARG THR PRO SEP LEU PRO THR 60H n/a n/a
47 5N5R - NV1 C13 H20 N2 O Cc1cccc(c1....
48 4DHM - 0KB C15 H13 F3 N O5 P c1ccc(c(c1....
49 4DAT - SER SER PHE TYR PRO SEP ALA GLU GLY n/a n/a
50 6Y8B - TYR ASP LEU SEP LEU PRO PHE PRO n/a n/a
51 6FI4 Kd = 2.2 uM PRO SEP LEU PRO DVA 60H n/a n/a
52 3IQU - GLN ARG SER THR SEP THR n/a n/a
53 4DHQ - Y06 C14 H13 Cl N O5 P c1ccc(c(c1....
54 4DHR - Y04 C14 H13 Cl N O5 P c1ccc(c(c1....
55 4Y3B ic50 = 90.1 uM 49F C7 H15 N O COCC[C@@H]....
56 5N5T - SER HIS SEP SER PRO ALA SER LEU n/a n/a
57 6HMU - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
58 6XXC - LYS ARG ARG ARG LYS SEP CYS GLN ALA O3W n/a n/a
59 6FBW Kd = 16.5 uM ARG THR PRO SEP LEU PRO GLY D4K n/a n/a
60 6FAV Kd = 4.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3Q n/a n/a
61 5MXO - FSC C36 H56 O12 C[C@@H]1[C....
62 6TL3 - NJW C24 H17 N3 O7 c1ccc(cc1)....
63 6FAU Kd = 3.6 uM ACE ARG THR PRO SEP LEU PRO GLY D3W n/a n/a
64 1QJB Ki = 416 nM ALA ARG SER HIS SEP TYR PRO ALA n/a n/a
65 6FNA - DWE C50 H66 N6 O20 P2 c1ccc(c(c1....
66 4N84 Kd = 41 nM GLY MKD LEU ASP MKD LEU ASP LEU ALA SER n/a n/a
67 1QJA Kd = 416 nM ARG LEU TYR HIS SEP LEU PRO ALA n/a n/a
68 6FNC - DWK C40 H48 N4 O15 P2 c1ccc(c(c1....
69 6FN9 ic50 = 284 uM DW8 C27 H38 N3 O10 P CCCNC(=O)C....
70 2C1N - ALA ARG LYS SEP THR GLY GLY LYS n/a n/a
71 2V7D Kd = 261 nM LYS SER ALA TPO THR THR VAL MET ASN PRO n/a n/a
72 6FNB - DWQ C59 H84 N6 O22 P2 c1ccc(c(c1....
73 3NKX Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
74 2BR9 - ARG ARG GLN ARG SEP ALA PRO n/a n/a
75 2C63 - ARG ALA ILE SEP LEU PRO n/a n/a
76 5NWI Kd = 0.69 uM TYR PHE SER SEP ASN n/a n/a
77 1O9D Kd = 2.5 uM GLN SER TYR TPO VAL n/a n/a
78 5NWJ - HIS LEU TYR PHE SER SEP ASN n/a n/a
79 3E6Y Kd = 2.5 uM CW1 C34 H52 O12 C[C@@H]1[C....
50% Homology Family (79)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 70 families.
1 6Y3W - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 O85 n/a n/a
2 6HKB - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
3 6FI5 Kd = 3 uM THR PRO SEP LEU PRO DAL 60H n/a n/a
4 5BTV Kd = 140 uM GLY SEP LEU GLY n/a n/a
5 6W0L - ALA ARG VAL SER MET ARG ARG MET SEP ASN n/a n/a
6 6XWD Kd = 2.18 uM ASN LYS ASN ALA ASN SEP SER PRO VAL n/a n/a
7 4Y32 ic50 = 90.1 uM ARG THR PRO SEP LEU PRO THR 49F n/a n/a
8 4Y5I ic50 = 301.3 uM ACE ARG THR PRO SEP LEU PRO THR PIP n/a n/a
9 6FBB - SER ARG SEP SER PRO n/a n/a
10 5N5W - 8OE C11 H8 Cl2 N2 O c1cc(ccc1N....
11 6FBY Kd = 9.3 uM ACE ARG THR PRO SEP LEU PRO GLY D4H n/a n/a
12 6Y3M - GLN SER TYR TPO VAL n/a n/a
13 6HHP Kd = 32 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
14 4DHS - Y03 C14 H12 Cl2 N O5 P c1ccc(c(c1....
15 6Y3S - ASN ALA ARG SER ALA SEP PHE SER GLN GLY n/a n/a
16 6GHP - ACE LYS ARG ARG LYS SEP VAL n/a n/a
17 4DHO - Y09 C15 H16 N O6 P COc1cccc(c....
18 6Y8A - ARG SER LEU SEP ALA PRO GLY ASN n/a n/a
19 6Y8E - ARG SER PHE SEP GLU PRO PHE GLY n/a n/a
20 3IQV Kd = 6.6 uM FSC C36 H56 O12 C[C@@H]1[C....
21 4IEA Kd = 346 nM ARG SER ALA SEP GLU PRO SER LEU n/a n/a
22 6HN2 - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
23 6Y58 Kd = 15.8 uM VAL TYR ARG SER LEU SEP PHE GLU n/a n/a
24 6FAW Kd = 2.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3K n/a n/a
25 5N75 - ARG SER HIS SEP SER PRO ALA SER LEU GLN n/a n/a
26 4DHN - 0KC C13 H18 N O5 P c1ccc(c(c1....
27 3MHR - ARG ALA HIS SEP SER PRO ALA SER LEU GLN n/a n/a
28 4DHP - Y07 C15 H12 Cl F3 N O5 P c1ccc(c(c1....
29 3LW1 Kd = 16.3 uM PHE LYS TPO GLU GLY PRO ASP SER ASP n/a n/a
30 3SP5 Kd = 0.56 uM LYS ARG ARG LYS SEP VAL n/a n/a
31 4DHU - 0KH C14 H12 Cl2 N O5 P c1ccc(c(c1....
32 6HMT Kd = 92 nM ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
33 6Y1D - LYS ARG ARG ARG LYS SEP CYS GLN ALA NH2 n/a n/a
34 6XY5 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O4E n/a n/a
35 3O8I - M1T C7 H14 O4 COCC(=O)CC....
36 6Y18 - LYS ARG ARG ARG LYS SEP CYS GLN ALA O68 n/a n/a
37 6TJM - NE5 C24 H16 N2 O8 c1ccc(cc1)....
38 5OEH - 9SZ C42 H32 O8 P2 c1ccc2c(c1....
39 4DHT - 0KG C14 H20 N O5 P c1ccc(c(c1....
40 6HKF - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
41 6Y3O - ARG LYS LEU SEP LEU GLN GLU ARG n/a n/a
42 6Y8D - VAL GLU HIS SEP LEU ASP ASN LYS n/a n/a
43 5LU1 - ARG ARG ALA SEP ALA PRO LEU PRO n/a n/a
44 3IQJ Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
45 4FR3 Kd = 0.07 uM 0V4 C27 H44 O8 C[C@@H]1[C....
46 5HF3 Kd = 13.4 uM ACE ARG THR PRO SEP LEU PRO THR 60H n/a n/a
47 5N5R - NV1 C13 H20 N2 O Cc1cccc(c1....
48 4DHM - 0KB C15 H13 F3 N O5 P c1ccc(c(c1....
49 4DAT - SER SER PHE TYR PRO SEP ALA GLU GLY n/a n/a
50 6Y8B - TYR ASP LEU SEP LEU PRO PHE PRO n/a n/a
51 6FI4 Kd = 2.2 uM PRO SEP LEU PRO DVA 60H n/a n/a
52 3IQU - GLN ARG SER THR SEP THR n/a n/a
53 4DHQ - Y06 C14 H13 Cl N O5 P c1ccc(c(c1....
54 4DHR - Y04 C14 H13 Cl N O5 P c1ccc(c(c1....
55 4Y3B ic50 = 90.1 uM 49F C7 H15 N O COCC[C@@H]....
56 5N5T - SER HIS SEP SER PRO ALA SER LEU n/a n/a
57 6HMU - ALA GLU GLY PHE PRO ALA TPO VAL n/a n/a
58 6XXC - LYS ARG ARG ARG LYS SEP CYS GLN ALA O3W n/a n/a
59 6FBW Kd = 16.5 uM ARG THR PRO SEP LEU PRO GLY D4K n/a n/a
60 6FAV Kd = 4.7 uM ACE ARG THR PRO SEP LEU PRO GLY D3Q n/a n/a
61 5MXO - FSC C36 H56 O12 C[C@@H]1[C....
62 6TL3 - NJW C24 H17 N3 O7 c1ccc(cc1)....
63 6FAU Kd = 3.6 uM ACE ARG THR PRO SEP LEU PRO GLY D3W n/a n/a
64 1QJB Ki = 416 nM ALA ARG SER HIS SEP TYR PRO ALA n/a n/a
65 6FNA - DWE C50 H66 N6 O20 P2 c1ccc(c(c1....
66 4N84 Kd = 41 nM GLY MKD LEU ASP MKD LEU ASP LEU ALA SER n/a n/a
67 1QJA Kd = 416 nM ARG LEU TYR HIS SEP LEU PRO ALA n/a n/a
68 6FNC - DWK C40 H48 N4 O15 P2 c1ccc(c(c1....
69 6FN9 ic50 = 284 uM DW8 C27 H38 N3 O10 P CCCNC(=O)C....
70 2C1N - ALA ARG LYS SEP THR GLY GLY LYS n/a n/a
71 2V7D Kd = 261 nM LYS SER ALA TPO THR THR VAL MET ASN PRO n/a n/a
72 6FNB - DWQ C59 H84 N6 O22 P2 c1ccc(c(c1....
73 3NKX Kd = 7.5 uM GLN ARG SER THR SEP THR PRO ASN VAL HIS n/a n/a
74 2BR9 - ARG ARG GLN ARG SEP ALA PRO n/a n/a
75 2C63 - ARG ALA ILE SEP LEU PRO n/a n/a
76 5NWI Kd = 0.69 uM TYR PHE SER SEP ASN n/a n/a
77 1O9D Kd = 2.5 uM GLN SER TYR TPO VAL n/a n/a
78 5NWJ - HIS LEU TYR PHE SER SEP ASN n/a n/a
79 3E6Y Kd = 2.5 uM CW1 C34 H52 O12 C[C@@H]1[C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: TYR ASP LEU SEP LEU PRO PHE PRO; Similar ligands found: 101
No: Ligand ECFP6 Tc MDL keys Tc
1 TYR ASP LEU SEP LEU PRO PHE PRO 1 1
2 TYR LEU GLY GLY PRO ASP PHE PRO THR ILE 0.552147 0.853333
3 PHE LEU PRO SER ASP PHE PHE PRO SER VAL 0.540541 0.837838
4 TYR GLN PHE GLY PRO ASP PHE PRO ILE ALA 0.530488 0.837838
5 TYR SEP PRO THR SEP PRO SER 0.521127 0.891892
6 ARG LEU TYR HIS SEP LEU PRO ALA 0.520958 0.8625
7 SER SER PHE TYR PRO SEP ALA GLU GLY 0.516129 0.944444
8 ASP TYR ASN PRO TYR LEU LEU PHE LEU LYS 0.512821 0.84
9 GLN LEU SER PRO PHE PRO PHE ASP LEU 0.509677 0.849315
10 SER ILE TYR PHE TPO PRO GLU LEU TYR ASP 0.505814 0.946667
11 ASP LEU PRO PHE 0.5 0.75
12 VAL ORN LEU DPN PRO VAL ORN LEU DPN PRO 0.5 0.753425
13 ASN ASP TRP LEU LEU PRO SER TYR 0.497041 0.844156
14 TYR MET PHE PRO ASN ALA PRO TYR LEU 0.490798 0.797468
15 PHE ALA PRO GLY ASN TYR PRO ALA LEU 0.47561 0.828947
16 TYR PRO PHE PHE NH2 0.474074 0.75
17 THR PRO SEP LEU PRO DAL 60H 0.470588 0.931507
18 LEU LEU PHE GLY PHE PRO VAL TYR VAL 0.469136 0.821918
19 LEU LEU PHE GLY TYR PRO VAL TYR VAL 0.469136 0.821918
20 PHE ASN PHE PRO GLN ILE THR 0.464516 0.786667
21 THR PRO SEP LEU PRO GLY D4H 0.462963 0.92
22 PHE SER ALA PTR PRO SER GLU GLU ASP 0.461538 0.891892
23 THR PRO SEP LEU PRO GLY D3W 0.460606 0.922078
24 TYR PRO TYR ASP VAL PRO ASP TYR ALA 0.460526 0.861111
25 LEU ASN PHE PRO ILE SER PRO 0.46 0.789474
26 PHE TYR ALA PRO GLU PRO ILE THR SER LEU 0.458824 0.855263
27 PHE LEU PRO HIS ALY TYR ASP VAL LYS LEU 0.458101 0.75641
28 PHE GLU ALA ILE PRO ALA GLU TYR LEU 0.454545 0.821918
29 PHE ALA PRO GLY PHE PHE PRO TYR LEU 0.453988 0.824324
30 HIS LEU TYR PHE SER SEP ASN 0.45283 0.805195
31 TYR LEU GLU PRO GLY PRO VAL THR ALA 0.451219 0.837838
32 HIS SER ILE THR TYR LEU LEU PRO VAL 0.450292 0.807692
33 ASP ASP LEU ASP VAL PRO SER PHE LEU GLN 0.45 0.797297
34 LEU GLN ARG VAL LEU SEP ALA PRO PHE 0.448485 0.797468
35 TYR LEU ALA PRO GLY PRO VAL THR ALA 0.446541 0.826667
36 THR PRO SEP LEU PRO GLY D3K 0.444444 0.8875
37 TYR LEU GLU PRO ALA PRO VAL THR ALA 0.44375 0.837838
38 TYR LEU GLU PRO GLY PRO VAL THR VAL 0.442424 0.837838
39 ARG ARG ALA SEP ALA PRO LEU PRO 0.440994 0.78481
40 LEU LEU PHE GLY LYS PRO VAL TYR VAL 0.440476 0.8
41 LEU TYR ALA SER PRO GLN LEU GLU GLY PHE 0.44 0.863014
42 GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.439024 0.808219
43 LYS LEU PRO ALA GLN PHE TYR ILE LEU 0.436782 0.824324
44 PRO SEP LEU PRO DVA 60H 0.433962 0.90411
45 LEU PRO PRO LEU ASP ILE THR PRO TYR 0.433735 0.849315
46 LEU PHE GLY TYR PRO VAL TYR VAL 0.432099 0.821918
47 PHE PRO THR LYS ASP VAL ALA LEU 0.431138 0.797297
48 TYR PHE SER SEP ASN 0.430556 0.693333
49 ARG THR PRO SEP LEU PRO THR 0.43038 0.820513
50 ARG THR PRO SEP LEU PRO THR 49F 0.43038 0.820513
51 ARG MET PHE PRO ASN ALA PRO TYR LEU 0.430168 0.752941
52 ALA ARG SER HIS SEP TYR PRO ALA 0.429379 0.82716
53 PHE GLU ASP ASN PHE VAL PRO 0.428571 0.76
54 ALA CYS SEP PRO GLN PHE GLY 0.428571 0.8
55 SER THR SEP PRO THR PHE ASN LYS 0.427746 0.853333
56 ASP PHE ALA ASN THR PHE LEU PRO 0.427673 0.824324
57 VAL VAL ARG PRO GLY SER LEU ASP LEU PRO 0.426901 0.746835
58 ARG ALA ILE SEP LEU PRO 0.426471 0.835616
59 ASP TYR GLU PRO ILE PRO GLU GLU ALA PHE 0.424419 0.849315
60 PHE ALA PRO GLY ASN TYI PRO ALA LEU 0.424419 0.777778
61 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.421687 0.727273
62 GLU ASP GLU ASP PHE GLU ILE LEU SEP LEU 0.421687 0.712329
63 GLU GLU ASN ASP PRO ASP TYR 0.42069 0.756757
64 TYR PRO ASN VAL ASN ILE HIS ASN PHE 0.41954 0.818182
65 N7P THR SEP PRO SER TYR SET 0.41875 0.868421
66 GLN ASN TYR PRO ILE VAL GLN 0.41875 0.786667
67 ACE GLU LEU LEU MET VAL PRO ASP MET TYR 0.418182 0.776316
68 ASP SEP TYR GLU VAL LEU ASP LEU 0.417178 0.777778
69 ARG SEP PRO VAL PHE SER 0.416667 0.794872
70 DTY ILE ARG LEU LPD 0.416667 0.721519
71 SER PHE PHE GLU ASP ASN PHE VAL PRO GLU 0.415094 0.8
72 LYS PRO SEP GLN GLU LEU 0.414966 0.849315
73 TYR LEU ASP SER GLY ILE HIS SER GLY ALA 0.414815 0.616438
74 SER HIS SEP SER PRO ALA SER LEU GLN 0.414773 0.844156
75 PHE LYS TPO GLU GLY PRO ASP SER ASP 0.412791 0.849315
76 ACE ARG THR PRO SEP LEU PRO THR 60H 0.411429 0.860759
77 PRO SER TYR SEP PRO THR SEP PRO SER 0.411043 0.891892
78 VAL TYR ARG SER LEU SEP PHE GLU 0.410596 0.689189
79 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.410526 0.766234
80 PHE ASN ARG PRO VAL 0.410256 0.675
81 LYS PRO ILE VAL GLN TYR ASP ASN PHE 0.410112 0.828947
82 ACE LEU TYR ALA SER SER ASN PRO ALA PTR 0.409357 0.934211
83 TYR PRO TYR 0.409091 0.75
84 ARG THR PHE SER PRO THR TYR GLY LEU 0.409091 0.822785
85 ASP TYR ILE ASN THR ASN VAL LEU PRO 0.408537 0.813333
86 ALA ILE ALA TYR PHE ILE PRO ASP GLN ALA 0.406452 0.780822
87 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.406061 0.679487
88 ACE ARG THR PRO SEP LEU PRO THR PIP 0.406061 0.802469
89 LEU PRO PHE ASP LYS THR THR ILE MET 0.405714 0.746835
90 ALA ASP PBF PTR LEU ILE PRO 0.405556 0.906667
91 ARG ALA HIS SEP SER PRO ALA SER LEU GLN 0.404762 0.844156
92 PHE GLN PRO GLN ASN GLY GLN PHE ILE 0.404762 0.736842
93 ASP PHE GLU GLU ILE PRO GLY GLU TYR LEU 0.404494 0.837838
94 SER PRO ILE VAL PRO SER PHE ASP MET 0.403509 0.759494
95 TYR LEU LYS GLU PRO VAL HIS GLY VAL 0.403315 0.789474
96 PHE SER HIS PRO GLN ASN THR 0.402367 0.766234
97 TYR LEU ASP SEP GLY ILE HIS SER GLY ALA 0.402299 0.797468
98 ARG GLN PHE GLY PRO ASP PHE PRO THR ILE 0.402174 0.775
99 ARG SER LEU SEP ALA PRO GLY ASN 0.401235 0.775
100 ARG ARG LEU PRO ILE PHE SER ARG LEU 0.401163 0.7375
101 THR PRO ASP TYR PHE LEU 0.4 0.753425
Similar Ligands (3D)
Ligand no: 1; Ligand: TYR ASP LEU SEP LEU PRO PHE PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
Feedback