Home
Faq
Browse
Search
Download
Contact Us
Help?
For full functionality of this site it is necessary to enable JavaScript. Here are the
instructions how to enable JavaScript in your web browser
.
Showing PDB: 6z10
Navigate
Expand All
|
Collapse All
Receptor
|
Ligand
|
View in 3D
Family:
90%
|
70%
|
50%
|
site
External Links
|
Download
Structure Biounit | Ligand Information
PDB :
.ZIP
|
.CSV
Family 90% :
.ZIP
|
.CSV
Class :
.ZIP
|
.CSV
Found one PDB record: 6XVW
Receptor
PDB id
Resolution
Class
Description
Source
Keywords
6z10
2.27 Å
NON-ENZYME:
SIGNAL_HORMONE
CRYSTAL STRUCTURE OF A HUMANIZED (K18E, K269N) RAT SUCCINATE SUCNR1 (GPR91) IN COMPLEX WITH A NANOBODY AND ANTAGONIST
RATTUS NORVEGICUS
G PROTEIN-COUPLED RECEPTOR GPCR SUCCINATE RECEPTOR MEMBRANE
Ref.:
DISCOVERY AND OPTIMIZATION OF NOVEL SUCNR1 INHIBITO DESIGN OF ZWITTERIONIC DERIVATIVES WITH A SALT BRID THE IMPROVEMENT OF ORAL EXPOSURE. J.MED.CHEM. V. 63 9856 2020
Ligand
Ligand
Chain:Residue
Validity
Ligand Warnings
Binding Data
NGL Viewer
Molecular Weight (Da)
Formula
SMILES
OLC
A:412;
A:405;
A:411;
A:408;
A:403;
A:404;
A:413;
A:409;
A:402;
A:410;
A:407;
A:406;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
356.54
C21 H40 O4
CCCCC...
SO4
A:414;
Invalid;
none;
submit data
96.063
O4 S
[O-]S...
Q4T
A:401;
Valid;
none;
submit data
518.912
C26 H22 Cl F3 N2 O4
c1cc(...
CL
A:415;
Invalid;
none;
submit data
35.453
Cl
[Cl-]
View in 3D viewer
90% Homology Family
Leader
PDB id
Resolution
Class
Description
Source
Keywords
6RNK
1.94 Å
NON-ENZYME:
SIGNAL_HORMONE
CRYSTAL STRUCTURE OF A HUMANIZED (K18E, K269N) RAT SUCCINATE SUCNR1 (GPR91) IN COMPLEX WITH A NANOBODY AND ANTAGONIST NF
RATTUS NORVEGICUS
SUCNR1 GPR91 GPCR G-PROTEIN COUPLED RECEPTOR NANOBODY ANTAGONIST SUCCINATE COMPLEX MEMBRANE PROTEIN
Ref.:
STRUCTURAL BASIS OF SPECIES-SELECTIVE ANTAGONIST BI THE SUCCINATE RECEPTOR. NATURE V. 574 581 2019
Members (3)
No:
PDB id
Binding Data
Representative ligand
Formula
Smiles
The
Class
containing this family consists of a total of
289
families.
1
6IBB
-
H95
C6 H14 O2
C[C@H](CC[....
2
6Z10
-
Q4T
C26 H22 Cl F3 N2 O4
c1cc(c(c(c....
3
6RNK
-
KAZ
C27 H29 N3 O3
CN1CCN(CC1....
70% Homology Family (3)
No:
PDB id
Binding Data
Representative ligand
Formula
Smiles
The
Class
containing this family consists of a total of
214
families.
1
6IBB
-
H95
C6 H14 O2
C[C@H](CC[....
2
6Z10
-
Q4T
C26 H22 Cl F3 N2 O4
c1cc(c(c(c....
3
6RNK
-
KAZ
C27 H29 N3 O3
CN1CCN(CC1....
50% Homology Family (3)
No:
PDB id
Binding Data
Representative ligand
Formula
Smiles
The
Class
containing this family consists of a total of
181
families.
1
6IBB
-
H95
C6 H14 O2
C[C@H](CC[....
2
6Z10
-
Q4T
C26 H22 Cl F3 N2 O4
c1cc(c(c(c....
3
6RNK
-
KAZ
C27 H29 N3 O3
CN1CCN(CC1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: Q4T; Similar ligands found: 1
No:
Ligand
ECFP6 Tc
MDL keys Tc
1
Q4T
1
1
Similar Ligands (3D)
Ligand no: 1; Ligand: Q4T; Similar ligands found: 0
No:
Ligand
Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6RNK; Ligand: KAZ; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6rnk.bio1) has
19 residues
No:
Leader PDB
Ligand
Sequence Similarity
APoc FAQ