Receptor
PDB id Resolution Class Description Source Keywords
2WA4 2.5 Å EC: 1.14.11.30 FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE HOMO SAPIENS HYDROXYLASE DIOXYGENASE TRANSCRIPTION OXIDOREDUCTASE TRANSCRIPTION ACTIVATOR/INHIBITOR HYPOXIA
Ref.: STRUCTURAL BASIS FOR BINDING OF CYCLIC 2-OXOGLUTARA ANALOGUES TO FACTOR-INHIBITING HYPOXIA-INDUCIBLE FA BIOORG. MED. CHEM. LETT. V. 20 6125 2010
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
069 A:400;
A:401;
Valid;
Valid;
none;
none;
ic50 = 18 uM
153.135 C7 H7 N O3 c1cc(...
FE2 A:350;
Part of Protein;
none;
submit data
55.845 Fe [Fe+2...
SO4 A:402;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2WA4 2.5 Å EC: 1.14.11.30 FACTOR INHIBITING HIF-1 ALPHA WITH N,3-DIHYDROXYBENZAMIDE HOMO SAPIENS HYDROXYLASE DIOXYGENASE TRANSCRIPTION OXIDOREDUCTASE TRANSCRIPTION ACTIVATOR/INHIBITOR HYPOXIA
Ref.: STRUCTURAL BASIS FOR BINDING OF CYCLIC 2-OXOGLUTARA ANALOGUES TO FACTOR-INHIBITING HYPOXIA-INDUCIBLE FA BIOORG. MED. CHEM. LETT. V. 20 6125 2010
Members (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 5OPC ic50 = 29 uM A1Z C14 H11 Cl N2 O4 c1cc(cc(c1....
2 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
3 1MZF - AKG C5 H6 O5 C(CC(=O)O)....
4 2CGN - SIN C4 H6 O4 C(CC(=O)O)....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4Z2W - AKG C5 H6 O5 C(CC(=O)O)....
7 5OP8 ic50 = 66 uM A1H C13 H14 N8 O2 c1cn(nn1)C....
8 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
9 4Z1V - OGA C4 H5 N O5 C(C(=O)O)N....
10 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
11 5OP6 ic50 = 21 uM A0W C19 H27 N3 O6 C1CCC(CC1)....
12 1MZE - TAR C4 H6 O6 [C@H]([C@@....
13 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
14 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....
70% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 5OPC ic50 = 29 uM A1Z C14 H11 Cl N2 O4 c1cc(cc(c1....
2 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
3 1MZF - AKG C5 H6 O5 C(CC(=O)O)....
4 2CGN - SIN C4 H6 O4 C(CC(=O)O)....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4Z2W - AKG C5 H6 O5 C(CC(=O)O)....
7 5OP8 ic50 = 66 uM A1H C13 H14 N8 O2 c1cn(nn1)C....
8 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
9 4Z1V - OGA C4 H5 N O5 C(C(=O)O)N....
10 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
11 5OP6 ic50 = 21 uM A0W C19 H27 N3 O6 C1CCC(CC1)....
12 1MZE - TAR C4 H6 O6 [C@H]([C@@....
13 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
14 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....
50% Homology Family (14)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 5OPC ic50 = 29 uM A1Z C14 H11 Cl N2 O4 c1cc(cc(c1....
2 2W0X ic50 = 625 uM PD2 C7 H5 N O4 c1cnc(cc1C....
3 1MZF - AKG C5 H6 O5 C(CC(=O)O)....
4 2CGN - SIN C4 H6 O4 C(CC(=O)O)....
5 2WA4 ic50 = 18 uM 069 C7 H7 N O3 c1cc(cc(c1....
6 4Z2W - AKG C5 H6 O5 C(CC(=O)O)....
7 5OP8 ic50 = 66 uM A1H C13 H14 N8 O2 c1cn(nn1)C....
8 2WA3 ic50 = 1 mM A29 C8 H6 O4 c1cc(cc(c1....
9 4Z1V - OGA C4 H5 N O5 C(C(=O)O)N....
10 4AI8 ic50 > 100 uM DZA C6 H12 N2 O3 CN(C)NC(=O....
11 5OP6 ic50 = 21 uM A0W C19 H27 N3 O6 C1CCC(CC1)....
12 1MZE - TAR C4 H6 O6 [C@H]([C@@....
13 2YDE ic50 = 189 uM S2G C5 H8 O5 C(CC(=O)O)....
14 2YC0 ic50 = 1500 uM 2HG C5 H8 O5 C(CC(=O)O)....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 069; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 069 1 1
2 GQZ 0.428571 0.702703
3 BHO 0.421053 0.8
Similar Ligands (3D)
Ligand no: 1; Ligand: 069; Similar ligands found: 1363
No: Ligand Similarity coefficient
1 J9T 1.0000
2 7MU 0.9987
3 ISZ 0.9744
4 ASC 0.9739
5 A29 0.9722
6 NIZ 0.9712
7 CFI 0.9691
8 GAB 0.9678
9 3OC 0.9671
10 LNR 0.9660
11 45L 0.9643
12 FBM 0.9643
13 2AL 0.9638
14 3AB 0.9636
15 4CS 0.9633
16 WCE 0.9633
17 GJZ 0.9625
18 SHA 0.9622
19 3NT 0.9617
20 GZL 0.9612
21 53C 0.9610
22 3HB 0.9607
23 I1E 0.9606
24 FEH 0.9602
25 EDR 0.9594
26 PZI 0.9581
27 HQJ 0.9567
28 6TZ 0.9564
29 F9P 0.9559
30 SAF 0.9548
31 JFJ 0.9544
32 L5V 0.9535
33 LDP 0.9523
34 4NC 0.9520
35 PHU 0.9515
36 INO 0.9515
37 OVV 0.9511
38 TPA 0.9500
39 M4T 0.9497
40 263 0.9496
41 P9P 0.9495
42 R20 0.9494
43 DHB 0.9492
44 XX2 0.9487
45 BRT 0.9487
46 8GC 0.9485
47 NMJ 0.9481
48 JLZ 0.9479
49 E35 0.9477
50 3AL 0.9477
51 5HN 0.9475
52 ORO 0.9475
53 RJY 0.9474
54 VXX 0.9472
55 93K 0.9455
56 M3H 0.9447
57 9TW 0.9445
58 CHB 0.9442
59 FHB 0.9439
60 NNO 0.9438
61 3BZ 0.9438
62 4P5 0.9430
63 4A3 0.9429
64 DOR 0.9427
65 L99 0.9426
66 HDH 0.9425
67 MYJ 0.9421
68 QSB 0.9411
69 2HO 0.9408
70 173 0.9408
71 ES2 0.9408
72 KTA 0.9406
73 97T 0.9399
74 4V2 0.9397
75 PKU 0.9393
76 MNN 0.9391
77 IHB 0.9388
78 FBW 0.9387
79 AX3 0.9385
80 J6W 0.9385
81 3HM 0.9384
82 1DJ 0.9383
83 D1X 0.9383
84 EOL 0.9382
85 DIN 0.9374
86 FBB 0.9374
87 3LR 0.9374
88 3HP 0.9374
89 OW4 0.9371
90 VNL 0.9371
91 OVM 0.9371
92 4JQ 0.9370
93 PAC 0.9369
94 R9Y 0.9369
95 BZ3 0.9367
96 K2T 0.9366
97 J9N 0.9365
98 ONR 0.9361
99 XQ0 0.9360
100 DE5 0.9359
101 MXN 0.9359
102 J9Q 0.9358
103 PEA 0.9353
104 0F9 0.9353
105 1M2 0.9353
106 AL0 0.9352
107 ALE 0.9350
108 XDE 0.9350
109 BEN 0.9347
110 2EC 0.9346
111 FAN 0.9344
112 2BG 0.9342
113 HHA 0.9342
114 BEZ 0.9342
115 Q88 0.9340
116 MLT 0.9338
117 HY1 0.9335
118 SMN 0.9334
119 GTQ 0.9331
120 XIY 0.9330
121 PIM 0.9329
122 MRW 0.9328
123 L22 0.9327
124 3HA 0.9326
125 MPV 0.9325
126 OXC 0.9324
127 3F0 0.9324
128 92P 0.9323
129 PBC 0.9322
130 4HM 0.9322
131 3BU 0.9321
132 1P3 0.9321
133 KJU 0.9320
134 H4E 0.9318
135 LYL 0.9318
136 EV0 0.9317
137 B2J 0.9317
138 QX4 0.9317
139 3Z8 0.9316
140 6RQ 0.9315
141 H7Y 0.9315
142 NCA 0.9315
143 CXF 0.9314
144 XCZ 0.9312
145 51R 0.9310
146 3PF 0.9309
147 94W 0.9308
148 URC 0.9308
149 2LY 0.9307
150 SKM 0.9304
151 OK7 0.9303
152 TT4 0.9303
153 I3A 0.9303
154 F31 0.9300
155 8OZ 0.9300
156 9R5 0.9299
157 03V 0.9298
158 8WT 0.9298
159 QBK 0.9297
160 268 0.9296
161 NYL 0.9296
162 AS3 0.9294
163 IWT 0.9294
164 B62 0.9293
165 DBH 0.9293
166 52C 0.9293
167 AJV 0.9292
168 MQN 0.9290
169 3MB 0.9290
170 3C4 0.9290
171 42J 0.9289
172 ES5 0.9288
173 4ME 0.9288
174 AW5 0.9288
175 6PC 0.9288
176 OTR 0.9287
177 SX1 0.9286
178 2ZM 0.9282
179 DHK 0.9281
180 OCH 0.9280
181 86J 0.9280
182 TAG 0.9280
183 X0V 0.9279
184 GRO 0.9279
185 BAM 0.9278
186 0TU 0.9277
187 OVP 0.9276
188 BNF 0.9276
189 2HQ 0.9275
190 717 0.9275
191 GDE 0.9273
192 PEL 0.9273
193 TGX 0.9272
194 44V 0.9271
195 AC0 0.9271
196 2F6 0.9271
197 M1Z 0.9270
198 TYL 0.9270
199 0HN 0.9269
200 BHA 0.9268
201 COU 0.9266
202 UNU 0.9266
203 3M0 0.9265
204 OMD 0.9265
205 1P8 0.9264
206 KOJ 0.9264
207 1A7 0.9263
208 DQU 0.9263
209 V55 0.9263
210 DOB 0.9262
211 NIO 0.9262
212 5GU 0.9262
213 EUG 0.9261
214 XDK 0.9259
215 ABI 0.9259
216 2AQ 0.9258
217 8ZE 0.9257
218 C2Y 0.9256
219 PIY 0.9256
220 15E 0.9255
221 H42 0.9254
222 PZA 0.9253
223 4FS 0.9250
224 VGD 0.9250
225 GVG 0.9249
226 A7W 0.9248
227 AX7 0.9247
228 M4E 0.9246
229 6ME 0.9245
230 LT2 0.9244
231 JZ7 0.9243
232 1F1 0.9243
233 0P6 0.9243
234 5QY 0.9242
235 KT7 0.9240
236 OGA 0.9240
237 HJH 0.9239
238 0FO 0.9238
239 0HO 0.9238
240 NBZ 0.9238
241 34D 0.9237
242 BNS 0.9237
243 36R 0.9236
244 4JT 0.9235
245 8TX 0.9235
246 RM1 0.9234
247 MUA 0.9233
248 CEE 0.9233
249 OAA 0.9233
250 XAZ 0.9232
251 SAL 0.9232
252 QSH 0.9231
253 ET2 0.9230
254 KUF 0.9230
255 8WO 0.9230
256 QMP 0.9229
257 5XC 0.9229
258 2LP 0.9229
259 JZ4 0.9228
260 XHP 0.9227
261 PHE 0.9226
262 N2Z 0.9225
263 CWJ 0.9224
264 4YO 0.9224
265 SOR 0.9222
266 SD4 0.9222
267 4M0 0.9219
268 F4E 0.9219
269 QY9 0.9219
270 264 0.9218
271 VGL 0.9218
272 GYE 0.9217
273 PSJ 0.9217
274 AC6 0.9217
275 O2A 0.9214
276 5OB 0.9213
277 4ZA 0.9213
278 258 0.9212
279 HSO 0.9211
280 5M0 0.9211
281 ABV 0.9210
282 PRA 0.9210
283 PRZ 0.9210
284 5RG 0.9209
285 AKG 0.9208
286 BSX 0.9207
287 LPK 0.9207
288 FGZ 0.9207
289 LMR 0.9207
290 92K 0.9206
291 EGR 0.9206
292 FA0 0.9203
293 3DO 0.9203
294 4WL 0.9203
295 3A9 0.9203
296 54D 0.9202
297 K34 0.9202
298 5WV 0.9202
299 5VM 0.9201
300 8XL 0.9201
301 ZBT 0.9200
302 5NI 0.9200
303 FP1 0.9200
304 9TZ 0.9199
305 HX3 0.9199
306 5WZ 0.9197
307 54G 0.9197
308 G3E 0.9196
309 N2I 0.9196
310 7N0 0.9196
311 AOS 0.9195
312 6FZ 0.9195
313 463 0.9195
314 A13 0.9195
315 BE2 0.9195
316 C2A 0.9195
317 YCP 0.9194
318 CWS 0.9193
319 7VP 0.9193
320 S2P 0.9191
321 OTW 0.9191
322 5RN 0.9190
323 F0J 0.9190
324 PPY 0.9188
325 D48 0.9188
326 CLW 0.9188
327 3ID 0.9188
328 SS1 0.9187
329 EKZ 0.9186
330 2MI 0.9184
331 AEH 0.9184
332 2FY 0.9184
333 4PN 0.9183
334 7ME 0.9183
335 SE2 0.9182
336 TIU 0.9182
337 RMN 0.9182
338 4FH 0.9182
339 SRO 0.9180
340 PDC 0.9179
341 TZL 0.9178
342 NTN 0.9178
343 8CM 0.9176
344 R2P 0.9176
345 6NT 0.9176
346 44W 0.9175
347 BCU 0.9175
348 RSO 0.9174
349 URS 0.9173
350 MWP 0.9173
351 HIS 0.9172
352 MS9 0.9172
353 2A9 0.9171
354 O45 0.9171
355 XBT 0.9171
356 3U4 0.9171
357 J5I 0.9170
358 GLY GLY 0.9169
359 4Z4 0.9169
360 4SX 0.9169
361 23J 0.9169
362 E7Z 0.9168
363 YRL 0.9167
364 MVN 0.9166
365 ICO 0.9166
366 BTY 0.9165
367 BZ2 0.9165
368 PD2 0.9165
369 2HC 0.9164
370 FBJ 0.9163
371 SS2 0.9163
372 FE DB1 0.9161
373 C9E 0.9159
374 5JL 0.9159
375 6CS 0.9158
376 DMD 0.9158
377 ES6 0.9158
378 QSC 0.9157
379 5CU 0.9157
380 XM0 0.9156
381 CH9 0.9156
382 JBK 0.9155
383 PAB 0.9155
384 ZXD 0.9154
385 49F 0.9154
386 Q6T 0.9153
387 PHB 0.9152
388 B55 0.9151
389 5JQ 0.9151
390 TH7 0.9151
391 3NY 0.9150
392 NCT 0.9150
393 4FA 0.9148
394 6NI 0.9143
395 XQI 0.9142
396 7B4 0.9142
397 ASP 0.9141
398 SYC 0.9140
399 2D0 0.9140
400 2HU 0.9140
401 HX4 0.9140
402 9RW 0.9140
403 GLO 0.9139
404 5NU 0.9139
405 FOT 0.9139
406 HPS 0.9138
407 AHR 0.9137
408 3QM 0.9136
409 DHS 0.9136
410 K5W 0.9136
411 DHY 0.9135
412 5RO 0.9134
413 1Y6 0.9133
414 KDV 0.9132
415 N3W 0.9132
416 2FQ 0.9131
417 HL5 0.9130
418 3SK 0.9129
419 42C 0.9128
420 MR1 0.9128
421 NPO 0.9127
422 9FL 0.9127
423 1AL 0.9125
424 QBM 0.9124
425 0W1 0.9122
426 JAW 0.9121
427 QUS 0.9121
428 ES7 0.9120
429 GOJ 0.9119
430 ESP 0.9119
431 270 0.9118
432 AH8 0.9118
433 ZZ3 0.9116
434 PBZ 0.9114
435 SJ5 0.9114
436 DHI 0.9113
437 PH2 0.9113
438 HHR 0.9113
439 SRT 0.9111
440 SR1 0.9111
441 4AA 0.9111
442 FA1 0.9111
443 75K 0.9110
444 BNL 0.9110
445 N8Y 0.9109
446 8NX 0.9109
447 PO6 0.9108
448 KBB 0.9107
449 0BP 0.9105
450 B85 0.9105
451 IFP 0.9105
452 BGC 0.9105
453 E7S 0.9104
454 JB5 0.9101
455 2AK 0.9099
456 1P7 0.9099
457 HBD 0.9099
458 PBA 0.9098
459 JND 0.9098
460 JAE 0.9095
461 F05 0.9095
462 BDP 0.9095
463 TSS 0.9093
464 PNZ 0.9092
465 AMH 0.9091
466 P72 0.9091
467 7WV 0.9091
468 SOL 0.9090
469 DYA 0.9090
470 CK1 0.9089
471 DEE 0.9087
472 B3U 0.9087
473 ODO 0.9087
474 7W4 0.9086
475 G4D 0.9086
476 EMZ 0.9085
477 LEU 0.9085
478 JG8 0.9084
479 271 0.9084
480 HIC 0.9083
481 DHR 0.9083
482 GIF 0.9083
483 IP0 0.9083
484 7WG 0.9082
485 261 0.9082
486 DNF 0.9082
487 BZX 0.9082
488 ICB 0.9081
489 1WC 0.9081
490 EN1 0.9081
491 ISN 0.9080
492 14J 0.9080
493 JDN 0.9078
494 XX3 0.9078
495 XUL 0.9077
496 JB8 0.9077
497 M58 0.9075
498 TEO 0.9075
499 GLU 0.9074
500 46P 0.9074
501 1WD 0.9074
502 SDD 0.9073
503 P92 0.9073
504 AOT 0.9072
505 0N7 0.9072
506 M6W 0.9072
507 3FH 0.9072
508 PRY 0.9071
509 KKN 0.9070
510 428 0.9070
511 HL4 0.9068
512 4TU 0.9068
513 BE7 0.9067
514 EA1 0.9067
515 S76 0.9067
516 YTX 0.9067
517 M2K 0.9066
518 MUC 0.9066
519 Z5P 0.9066
520 VNJ 0.9063
521 CPZ 0.9063
522 2RH 0.9061
523 AKH 0.9061
524 FK8 0.9061
525 8IG 0.9060
526 4XV 0.9060
527 2HG 0.9060
528 RNS 0.9059
529 4LV 0.9059
530 BZE 0.9059
531 P80 0.9058
532 COI 0.9057
533 CK2 0.9057
534 MSR 0.9057
535 XRG 0.9056
536 1QP 0.9055
537 PQ0 0.9055
538 HHH 0.9054
539 FQI 0.9054
540 HMH 0.9054
541 3HG 0.9053
542 HQ9 0.9053
543 SSB 0.9052
544 MEQ 0.9052
545 3IT 0.9051
546 IJZ 0.9051
547 NDH 0.9050
548 M1Q 0.9048
549 1IT 0.9048
550 M45 0.9048
551 GAL 0.9047
552 HA5 0.9046
553 J9W 0.9046
554 IF7 0.9045
555 JKE 0.9044
556 ESX 0.9044
557 KDG 0.9044
558 PJW 0.9043
559 UGC 0.9042
560 7NI 0.9041
561 0JD 0.9041
562 HQD 0.9041
563 PMB 0.9041
564 1L5 0.9040
565 Z82 0.9040
566 DI6 0.9039
567 RNT 0.9038
568 7OD 0.9038
569 CWM 0.9038
570 CXH 0.9036
571 4HC 0.9035
572 DBX 0.9035
573 GLN 0.9035
574 9FE 0.9033
575 9CA 0.9031
576 FBU 0.9031
577 BPY 0.9030
578 APZ 0.9030
579 DGJ 0.9030
580 ADZ 0.9030
581 4XR 0.9029
582 GLC 0.9029
583 X0W 0.9026
584 MJ2 0.9024
585 9MG 0.9023
586 HCI 0.9022
587 A09 0.9022
588 MED 0.9021
589 BHH 0.9021
590 AJY 0.9021
591 DGL 0.9020
592 2IT 0.9020
593 JF6 0.9020
594 5MK 0.9020
595 11S 0.9018
596 SPA 0.9017
597 ES0 0.9016
598 KMT 0.9016
599 R8S 0.9016
600 AVI 0.9016
601 5MI 0.9016
602 ESI 0.9016
603 FB2 0.9015
604 PCA 0.9014
605 1XA 0.9014
606 13P 0.9014
607 F9Y 0.9013
608 IAC 0.9013
609 3R6 0.9013
610 F60 0.9012
611 EYK 0.9012
612 2EH 0.9011
613 7MX 0.9011
614 61M 0.9011
615 HGA 0.9010
616 8G0 0.9010
617 JXN 0.9010
618 YZM 0.9010
619 RUY 0.9009
620 BEA 0.9009
621 SVD 0.9009
622 GTR 0.9009
623 2PG 0.9009
624 S2G 0.9008
625 GLY CYS 0.9008
626 7VS 0.9008
627 3ZB 0.9007
628 TZF 0.9006
629 24W 0.9006
630 6Q3 0.9006
631 AEF 0.9006
632 14O 0.9005
633 4MA 0.9005
634 5H1 0.9004
635 9KH 0.9004
636 NOY 0.9003
637 ONH 0.9002
638 NOJ 0.9001
639 OHP 0.9001
640 F12 0.9001
641 SHI 0.9000
642 B40 0.9000
643 LYS 0.9000
644 5QX 0.9000
645 JTH 0.9000
646 826 0.8998
647 KTW 0.8997
648 2A7 0.8997
649 8W9 0.8996
650 5XB 0.8996
651 TTL 0.8995
652 2K4 0.8995
653 XYL 0.8994
654 RB5 0.8994
655 JYD 0.8994
656 PEP 0.8994
657 ASO 0.8993
658 7HQ 0.8993
659 9ZE 0.8991
660 D3G 0.8991
661 2CK 0.8991
662 CTL 0.8991
663 TWO 0.8990
664 36Y 0.8990
665 5B1 0.8990
666 DGN 0.8989
667 DFB 0.8989
668 FB1 0.8989
669 UFO 0.8988
670 4XS 0.8987
671 SW7 0.8987
672 IV2 0.8987
673 RAT 0.8987
674 C2U 0.8986
675 7C3 0.8985
676 AZ9 0.8984
677 AJ2 0.8984
678 1SQ 0.8984
679 GXY 0.8984
680 4SV 0.8983
681 DA4 0.8982
682 UFV 0.8982
683 DHC 0.8981
684 1LQ 0.8981
685 QDK 0.8981
686 HLZ 0.8981
687 6AI 0.8981
688 AY4 0.8980
689 LT1 0.8980
690 C1M 0.8979
691 293 0.8979
692 APG 0.8979
693 NCD 0.8979
694 DYT 0.8977
695 INE 0.8977
696 8GK 0.8977
697 AGK 0.8976
698 FUD 0.8976
699 1KP 0.8974
700 KDF 0.8974
701 4M4 0.8973
702 OW7 0.8972
703 ES9 0.8971
704 H4N 0.8971
705 ZZT 0.8971
706 RBJ 0.8971
707 5MB 0.8970
708 7WR 0.8970
709 6M9 0.8970
710 FYU 0.8969
711 R9S 0.8969
712 TSR 0.8968
713 N4B 0.8968
714 FDR 0.8967
715 AQO 0.8967
716 SNU 0.8966
717 Q24 0.8966
718 PBN 0.8966
719 DRL 0.8966
720 DQA 0.8966
721 4MU 0.8965
722 FK1 0.8965
723 12T 0.8965
724 DEW 0.8964
725 4HP 0.8964
726 ANN 0.8963
727 NLE 0.8962
728 0W8 0.8962
729 ISD 0.8962
730 JXZ 0.8961
731 I3E 0.8961
732 ADA 0.8961
733 GCU 0.8959
734 A5E 0.8958
735 PMF 0.8958
736 DIR 0.8958
737 ORN 0.8957
738 15N 0.8957
739 GUA 0.8957
740 PRF 0.8956
741 T2D 0.8955
742 SYN 0.8955
743 CFA 0.8955
744 MNP 0.8955
745 XQG 0.8954
746 SLS 0.8954
747 6M4 0.8954
748 7W1 0.8953
749 CTS 0.8953
750 PE0 0.8952
751 AZ8 0.8952
752 FA3 0.8952
753 6KT 0.8951
754 3QV 0.8950
755 FBV 0.8950
756 RD4 0.8950
757 4XF 0.8948
758 1NP 0.8946
759 E5X 0.8946
760 KJH 0.8945
761 DIE 0.8945
762 I4B 0.8945
763 TCA 0.8944
764 XAN 0.8944
765 BPN 0.8943
766 HIO 0.8942
767 IT2 0.8941
768 UNJ 0.8941
769 AMQ 0.8940
770 YPN 0.8940
771 1LN 0.8940
772 ZZZ 0.8940
773 TZM 0.8940
774 TLA 0.8940
775 S7S 0.8939
776 R8V 0.8938
777 M5K 0.8938
778 GLY PRO 0.8938
779 G2F 0.8937
780 6OT 0.8937
781 GCO 0.8937
782 IFL 0.8936
783 Q71 0.8936
784 XXG 0.8936
785 TZE 0.8936
786 VOH 0.8935
787 DAL DAL 0.8934
788 GUN 0.8933
789 G5V 0.8933
790 4BY 0.8932
791 4NM 0.8932
792 HBA 0.8932
793 60P 0.8932
794 QWN 0.8931
795 XLS 0.8931
796 ONL 0.8931
797 174 0.8930
798 IPB 0.8930
799 FUM 0.8930
800 CN0 0.8929
801 ASN 0.8927
802 GZQ 0.8927
803 MEW 0.8925
804 MO8 0.8925
805 A3M 0.8925
806 0FK 0.8923
807 M0Q 0.8923
808 SN4 0.8923
809 JYB 0.8923
810 OKG 0.8922
811 4LW 0.8922
812 8U3 0.8922
813 JZ5 0.8921
814 39O 0.8920
815 82I 0.8919
816 5SG 0.8918
817 NFM 0.8917
818 0LH 0.8917
819 N5J 0.8916
820 4BZ 0.8915
821 5IQ 0.8915
822 HMU 0.8915
823 40E 0.8914
824 4YS 0.8911
825 O72 0.8911
826 12Q 0.8910
827 UNC 0.8910
828 AMC 0.8910
829 M6Z 0.8909
830 4ZC 0.8908
831 ZME 0.8907
832 GGL 0.8906
833 QIC 0.8906
834 42A 0.8906
835 HQT 0.8905
836 CIT 0.8905
837 1LM 0.8904
838 P7Y 0.8903
839 259 0.8903
840 SXS 0.8903
841 HJP 0.8902
842 SIN 0.8902
843 3DM 0.8902
844 3XX 0.8900
845 1DW 0.8900
846 DS0 0.8900
847 SKA 0.8899
848 JPZ 0.8898
849 SEP 0.8898
850 HXX 0.8898
851 8H8 0.8897
852 M3E 0.8896
853 4VY 0.8896
854 II6 0.8893
855 1PT 0.8893
856 NPY 0.8892
857 IFM 0.8891
858 KTJ 0.8890
859 ROR 0.8889
860 CIY 0.8889
861 PJL 0.8889
862 KJY 0.8888
863 GF4 0.8888
864 E1T 0.8888
865 4A5 0.8888
866 1H1 0.8887
867 HSM 0.8887
868 DIU 0.8886
869 SYV 0.8886
870 KP6 0.8886
871 GBD 0.8886
872 4VP 0.8885
873 ES1 0.8884
874 4P0 0.8884
875 QPR 0.8882
876 QXW 0.8882
877 0RW 0.8880
878 JRB 0.8880
879 GLA 0.8878
880 9DG 0.8875
881 ABN 0.8875
882 PH3 0.8874
883 SAN 0.8872
884 DBJ 0.8871
885 QUZ 0.8871
886 6LW 0.8870
887 MAJ 0.8869
888 AEG 0.8869
889 TSU 0.8869
890 KMH 0.8868
891 4BL 0.8867
892 HBX 0.8866
893 23A 0.8864
894 NGT 0.8864
895 3SL 0.8864
896 RBL 0.8863
897 8NY 0.8863
898 2UZ 0.8862
899 LCN 0.8861
900 5Q0 0.8860
901 M6H 0.8860
902 795 0.8859
903 RIB 0.8859
904 7Q1 0.8857
905 3YP 0.8857
906 X05 0.8854
907 GAG 0.8853
908 5VL 0.8853
909 Q02 0.8852
910 24B 0.8852
911 1DV 0.8852
912 TZC 0.8852
913 3PG 0.8851
914 BPU 0.8851
915 SVN 0.8851
916 8S0 0.8851
917 1Z6 0.8850
918 HHI 0.8850
919 Q03 0.8849
920 GV9 0.8848
921 HNL 0.8848
922 6VD 0.8848
923 F06 0.8847
924 CLZ 0.8847
925 4AV 0.8846
926 OXZ 0.8845
927 2FT 0.8845
928 DHQ 0.8845
929 B57 0.8845
930 X48 0.8844
931 LGC 0.8844
932 1GP 0.8841
933 209 0.8841
934 GAF 0.8841
935 LYN 0.8841
936 SWA 0.8840
937 HQY 0.8839
938 7BC 0.8838
939 8GL 0.8838
940 URO 0.8837
941 9EW 0.8836
942 1SA 0.8834
943 FF3 0.8834
944 DPN 0.8834
945 G3F 0.8833
946 G3P 0.8833
947 FCR 0.8832
948 M5H 0.8830
949 TYR 0.8830
950 PYJ 0.8830
951 5AC 0.8830
952 P3K 0.8829
953 MET 0.8828
954 SYM 0.8828
955 M1A 0.8827
956 FBS 0.8827
957 TP5 0.8827
958 X0U 0.8826
959 492 0.8826
960 AZF 0.8826
961 FRU 0.8825
962 149 0.8825
963 1GN 0.8824
964 A9P 0.8824
965 2FG 0.8824
966 HX2 0.8823
967 GLY ALA 0.8823
968 HC4 0.8823
969 B09 0.8821
970 5WY 0.8820
971 PRO 0.8820
972 F2W 0.8819
973 ZYR 0.8819
974 9BF 0.8819
975 GCB 0.8818
976 XIZ 0.8817
977 9ON 0.8816
978 HDL 0.8816
979 AZA 0.8816
980 KW8 0.8815
981 GZ2 0.8814
982 TRA 0.8813
983 K7M 0.8813
984 TLM 0.8812
985 NGO 0.8811
986 0XT 0.8811
987 X6X 0.8810
988 92G 0.8809
989 4J8 0.8809
990 IGA 0.8808
991 L13 0.8807
992 3OL 0.8806
993 EHM 0.8806
994 6HO 0.8806
995 GWM 0.8805
996 PEQ 0.8805
997 0V5 0.8805
998 PYC 0.8802
999 GJP 0.8801
1000 B5D 0.8801
1001 HH8 0.8801
1002 363 0.8801
1003 CXP 0.8800
1004 7B3 0.8800
1005 ALA ALA 0.8799
1006 B24 0.8799
1007 TTY 0.8799
1008 PZM 0.8798
1009 G3H 0.8798
1010 36M 0.8798
1011 AAS 0.8798
1012 HF2 0.8798
1013 KBG 0.8797
1014 NFA 0.8797
1015 LZM 0.8797
1016 GIV 0.8796
1017 DAS 0.8796
1018 5F5 0.8795
1019 PXL 0.8795
1020 4XH 0.8795
1021 15L 0.8795
1022 HFA 0.8794
1023 PYF 0.8793
1024 8HC 0.8792
1025 GO2 0.8792
1026 D07 0.8791
1027 MBG 0.8791
1028 N7I 0.8791
1029 BP7 0.8790
1030 SNE 0.8789
1031 36E 0.8788
1032 MAQ 0.8787
1033 TYE 0.8786
1034 2O6 0.8786
1035 S24 0.8785
1036 PEY 0.8785
1037 32X 0.8784
1038 NAG 0.8783
1039 AN0 0.8782
1040 NVU 0.8782
1041 R67 0.8780
1042 NPA 0.8780
1043 NSP 0.8779
1044 CFP 0.8777
1045 VM1 0.8777
1046 EOU 0.8776
1047 F69 0.8776
1048 EVA 0.8775
1049 HH5 0.8775
1050 8NB 0.8774
1051 APS 0.8774
1052 BP9 0.8773
1053 4RU 0.8772
1054 GP9 0.8772
1055 ALL 0.8772
1056 BK9 0.8772
1057 NID 0.8770
1058 YH7 0.8770
1059 FHC 0.8770
1060 OHG 0.8770
1061 67N 0.8769
1062 APY 0.8769
1063 A2F 0.8768
1064 6R8 0.8768
1065 JZ3 0.8768
1066 HNK 0.8767
1067 IOP 0.8767
1068 IZC 0.8767
1069 152 0.8766
1070 6AP 0.8766
1071 FDK 0.8766
1072 IHG 0.8766
1073 P84 0.8765
1074 UAN 0.8764
1075 M44 0.8764
1076 F81 0.8764
1077 SC2 0.8764
1078 0NX 0.8763
1079 X11 0.8762
1080 I38 0.8762
1081 GXL 0.8762
1082 344 0.8761
1083 RSF 0.8761
1084 FDB 0.8760
1085 6DP 0.8760
1086 14W 0.8760
1087 51F 0.8760
1088 K97 0.8760
1089 0GZ 0.8760
1090 XXP 0.8759
1091 1HN 0.8758
1092 SME 0.8758
1093 AN3 0.8757
1094 FOA 0.8756
1095 OXQ 0.8756
1096 GCS 0.8754
1097 DX4 0.8754
1098 IDM 0.8754
1099 JF1 0.8753
1100 SQ7 0.8753
1101 2K8 0.8751
1102 HPA 0.8751
1103 MZB 0.8750
1104 EWG 0.8750
1105 BQ2 0.8750
1106 ARP 0.8750
1107 OOG 0.8750
1108 EXD 0.8749
1109 A9O 0.8749
1110 X1R 0.8748
1111 5LA 0.8748
1112 KYA 0.8748
1113 HSE 0.8747
1114 M1H 0.8747
1115 9RH 0.8746
1116 DE3 0.8745
1117 PGH 0.8745
1118 B60 0.8741
1119 141 0.8740
1120 C21 0.8740
1121 282 0.8739
1122 AZG 0.8738
1123 9CL 0.8738
1124 HBO 0.8737
1125 XSP 0.8737
1126 GZ3 0.8736
1127 TOF 0.8736
1128 6J9 0.8736
1129 LEL 0.8736
1130 HPT 0.8736
1131 6L6 0.8735
1132 NDG 0.8734
1133 B4O 0.8734
1134 SYA 0.8734
1135 SHF 0.8733
1136 5TY 0.8732
1137 MNM 0.8731
1138 EYV 0.8731
1139 K6V 0.8731
1140 1MR 0.8730
1141 ADE 0.8730
1142 9UL 0.8730
1143 DNC 0.8729
1144 PFL 0.8729
1145 TIH 0.8728
1146 AMS 0.8728
1147 NXA 0.8727
1148 1BN 0.8727
1149 GJS 0.8726
1150 6XI 0.8726
1151 RHU 0.8726
1152 6M1 0.8726
1153 2CQ 0.8724
1154 HLD 0.8724
1155 MEV 0.8723
1156 H33 0.8723
1157 LAO 0.8721
1158 6GU 0.8721
1159 JBE 0.8718
1160 FH2 0.8716
1161 AHN 0.8715
1162 0OC 0.8715
1163 MLE 0.8715
1164 2H5 0.8713
1165 WOO 0.8712
1166 GZ8 0.8711
1167 0FN 0.8708
1168 4NB 0.8707
1169 56D 0.8707
1170 MAN 0.8704
1171 6QF 0.8702
1172 ROI 0.8702
1173 TAR 0.8702
1174 FBA 0.8701
1175 FLC 0.8701
1176 30G 0.8700
1177 AMR 0.8700
1178 SNO 0.8700
1179 XEN 0.8700
1180 RNO 0.8699
1181 ICF 0.8699
1182 MQB 0.8698
1183 S8D 0.8698
1184 DRG 0.8697
1185 HKD 0.8697
1186 MXD 0.8697
1187 JBN 0.8696
1188 2BX 0.8695
1189 FPI 0.8695
1190 3MV 0.8694
1191 SOE 0.8694
1192 X8Z 0.8693
1193 3MG 0.8693
1194 4JL 0.8691
1195 G2H 0.8690
1196 JP2 0.8690
1197 SPV 0.8688
1198 1XM 0.8688
1199 I6G 0.8687
1200 C2B 0.8687
1201 M0W 0.8686
1202 45C 0.8686
1203 2ZQ 0.8686
1204 HLR 0.8685
1205 150 0.8685
1206 68A 0.8684
1207 HYP 0.8682
1208 SMV 0.8682
1209 290 0.8681
1210 GBN 0.8681
1211 P4B 0.8681
1212 MAH 0.8680
1213 CFF 0.8680
1214 28N 0.8680
1215 DEN 0.8676
1216 V1T 0.8675
1217 0R0 0.8674
1218 AFR 0.8673
1219 25W 0.8673
1220 1U6 0.8673
1221 TRC 0.8672
1222 47J 0.8671
1223 BOA 0.8670
1224 IOS 0.8669
1225 HHS 0.8668
1226 791 0.8667
1227 2PC 0.8667
1228 LQ2 0.8666
1229 HA7 0.8663
1230 1XN 0.8663
1231 ICT 0.8663
1232 MCO 0.8662
1233 27B 0.8662
1234 1WG 0.8661
1235 4I8 0.8661
1236 OA3 0.8660
1237 WOT 0.8660
1238 IPZ 0.8659
1239 SHG 0.8659
1240 ATX 0.8658
1241 41K 0.8658
1242 6F0 0.8658
1243 7O4 0.8657
1244 PPT 0.8655
1245 X6P 0.8654
1246 NF3 0.8653
1247 55D 0.8653
1248 549 0.8652
1249 CCV 0.8650
1250 JR2 0.8650
1251 NK 0.8649
1252 H8N 0.8648
1253 3CR 0.8648
1254 HY3 0.8648
1255 TC7 0.8647
1256 SWD 0.8647
1257 HCS 0.8646
1258 JU2 0.8646
1259 286 0.8645
1260 2AS 0.8644
1261 091 0.8643
1262 DX3 0.8643
1263 GVY 0.8642
1264 7ZE 0.8642
1265 OTD 0.8642
1266 2KA 0.8642
1267 PY7 0.8642
1268 ANC 0.8641
1269 PA1 0.8640
1270 2TQ 0.8640
1271 4JM 0.8640
1272 GDL 0.8639
1273 JA8 0.8638
1274 BPW 0.8637
1275 EVF 0.8635
1276 8K2 0.8635
1277 2D8 0.8632
1278 10L 0.8631
1279 B53 0.8631
1280 MES 0.8630
1281 T9G 0.8630
1282 9DA 0.8629
1283 W81 0.8628
1284 3VX 0.8628
1285 7HP 0.8626
1286 6ZX 0.8626
1287 B2Y 0.8622
1288 2DR 0.8621
1289 273 0.8621
1290 IND 0.8617
1291 1CO 0.8617
1292 HNH 0.8617
1293 LLQ 0.8617
1294 SLC 0.8615
1295 MT0 0.8614
1296 6MP 0.8614
1297 JBH 0.8614
1298 VK3 0.8614
1299 MZT 0.8613
1300 NBE 0.8613
1301 9SE 0.8611
1302 XYD 0.8610
1303 DLT 0.8608
1304 M4S 0.8605
1305 37T 0.8605
1306 JZ9 0.8600
1307 MZG 0.8600
1308 TH0 0.8600
1309 WBU 0.8598
1310 GRE 0.8597
1311 LKA 0.8597
1312 9HX 0.8596
1313 QIV 0.8595
1314 PGA 0.8594
1315 1DU 0.8593
1316 BDF 0.8592
1317 BCP 0.8591
1318 MCT 0.8590
1319 4JJ 0.8590
1320 495 0.8590
1321 SBK 0.8587
1322 BZI 0.8587
1323 H76 0.8587
1324 LZ1 0.8586
1325 NQ 0.8585
1326 N91 0.8584
1327 9X7 0.8584
1328 ENO 0.8584
1329 BMA 0.8582
1330 NHG 0.8581
1331 AIN 0.8580
1332 AAN 0.8579
1333 KFH 0.8577
1334 Q77 0.8575
1335 CCU 0.8575
1336 MWJ 0.8572
1337 BTE 0.8571
1338 URP 0.8571
1339 5JC 0.8571
1340 N9J 0.8568
1341 FBT 0.8568
1342 PYQ 0.8567
1343 LFR 0.8565
1344 0CU 0.8564
1345 4HO 0.8562
1346 X09 0.8560
1347 LDU 0.8559
1348 QBS 0.8554
1349 JF2 0.8554
1350 7WA 0.8553
1351 1MC 0.8550
1352 ES4 0.8543
1353 40F 0.8543
1354 Q7A 0.8541
1355 49O 0.8540
1356 PM6 0.8530
1357 DNA 0.8523
1358 ITN 0.8521
1359 BP1 0.8520
1360 AVA 0.8517
1361 5NE 0.8514
1362 XCG 0.8513
1363 TMG 0.8510
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2WA4; Ligand: 069; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2wa4.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2WA4; Ligand: 069; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2wa4.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 2WA4; Ligand: 069; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 2wa4.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 2WA4; Ligand: 069; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 2wa4.bio1) has 25 residues
No: Leader PDB Ligand Sequence Similarity
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