Receptor
PDB id Resolution Class Description Source Keywords
3AO1 1.9 Å EC: 2.7.7.7 FRAGMENT-BASED APPROACH TO THE DESIGN OF LIGANDS TARGETING A SITE IN HIV-1 INTEGRASE HUMAN IMMUNODEFICIENCY VIRUS 1 DNA INTEGRATION AIDS INTEGRASE ENDONUCLEASE POLYNUCLEOTITRANSFERASE DNA BINDING VIRAL PROTEIN RNASEH FRAGMENT BVIRAL PROTEIN-TRANSFERASE INHIBITOR COMPLEX
Ref.: FRAGMENT-BASED DESIGN OF LIGANDS TARGETING A NOVEL THE INTEGRASE ENZYME OF HUMAN IMMUNODEFICIENCY VIRU CHEMMEDCHEM V. 6 258 2011
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
BZX A:213;
A:214;
B:1;
Valid;
Valid;
Valid;
none;
none;
none;
Kd = 5.5 mM
138.121 C7 H6 O3 c1cc2...
CD A:1003;
A:1004;
B:1001;
B:1002;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
112.411 Cd [Cd+2...
SO4 A:1;
Invalid;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4E1N 2 Å EC: 2.7.7.7 CRYSTAL STRUCTURE OF HIV-1 INTEGRASE WITH A NON-CATAYLTIC SI INHIBITOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 HIV-1 INTEGRASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: NEW CLASS OF HIV-1 INTEGRASE (IN) INHIBITORS WITH A MODE OF ACTION. J.BIOL.CHEM. V. 287 21189 2012
Members (146)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 21 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
70% Homology Family (148)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
147 4E1M ic50 = 215 nM TQ2 C24 H27 N O3 Cc1ccc(cc1....
148 5HRN - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
50% Homology Family (148)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
147 4E1M ic50 = 215 nM TQ2 C24 H27 N O3 Cc1ccc(cc1....
148 5HRN - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: BZX; Similar ligands found: 4
No: Ligand ECFP6 Tc MDL keys Tc
1 BZX 1 1
2 5XC 0.439024 0.857143
3 0HN 0.418605 0.862069
4 MR1 0.404762 0.676471
Similar Ligands (3D)
Ligand no: 1; Ligand: BZX; Similar ligands found: 1368
No: Ligand Similarity coefficient
1 5H1 1.0000
2 6AI 1.0000
3 14O 1.0000
4 5MI 1.0000
5 5MB 1.0000
6 F60 1.0000
7 2K4 1.0000
8 11S 0.9991
9 ES9 0.9986
10 H4N 0.9954
11 FK1 0.9941
12 JAE 0.9937
13 JB5 0.9870
14 COU 0.9869
15 8NY 0.9863
16 03V 0.9854
17 OCH 0.9852
18 H42 0.9851
19 4FS 0.9850
20 2AQ 0.9849
21 ES5 0.9848
22 ABV 0.9820
23 AX7 0.9790
24 QUZ 0.9776
25 RSF 0.9767
26 DEN 0.9766
27 2CK 0.9761
28 NPO 0.9758
29 5OB 0.9755
30 5WV 0.9751
31 1PT 0.9748
32 XYP 0.9747
33 36R 0.9745
34 CLW 0.9744
35 TH7 0.9743
36 270 0.9742
37 ET2 0.9738
38 6M9 0.9737
39 XQ0 0.9737
40 LXC 0.9736
41 DMD 0.9734
42 0CT 0.9733
43 AHR 0.9732
44 NPY 0.9730
45 JZ9 0.9728
46 BZ3 0.9727
47 4JT 0.9725
48 F05 0.9723
49 1P7 0.9722
50 P92 0.9722
51 AZA 0.9721
52 XAN 0.9721
53 BZI 0.9721
54 M1A 0.9718
55 RM1 0.9717
56 0RW 0.9716
57 ASO 0.9714
58 9DG 0.9714
59 IDM 0.9713
60 GUN 0.9713
61 IND 0.9712
62 9EW 0.9710
63 BZF 0.9709
64 3ID 0.9708
65 ISN 0.9705
66 MCT 0.9704
67 7W4 0.9697
68 6GU 0.9697
69 3DO 0.9693
70 MPI 0.9691
71 0R1 0.9691
72 A2F 0.9689
73 1P8 0.9689
74 5VM 0.9689
75 HLR 0.9687
76 LZ1 0.9685
77 1DW 0.9684
78 ES2 0.9684
79 67N 0.9682
80 SAL 0.9681
81 5B1 0.9680
82 OAA 0.9676
83 2MI 0.9675
84 ES7 0.9674
85 SVN 0.9674
86 PHB 0.9674
87 GVH 0.9673
88 TH0 0.9672
89 4HO 0.9672
90 HH5 0.9670
91 6M4 0.9669
92 8GC 0.9669
93 6AP 0.9668
94 HMH 0.9667
95 KKN 0.9664
96 YH7 0.9663
97 GLC 0.9663
98 I3A 0.9662
99 AZG 0.9661
100 IGA 0.9660
101 YCP 0.9659
102 141 0.9658
103 290 0.9654
104 URF 0.9651
105 LCN 0.9650
106 DX4 0.9648
107 BEZ 0.9648
108 F9Y 0.9646
109 1XM 0.9641
110 6PC 0.9640
111 7HQ 0.9639
112 NOJ 0.9639
113 4SV 0.9638
114 NCA 0.9634
115 MWM 0.9628
116 0CU 0.9626
117 VGD 0.9625
118 NK 0.9624
119 FYU 0.9622
120 1MC 0.9621
121 G2F 0.9616
122 BOA 0.9615
123 BGC 0.9615
124 BEN 0.9615
125 CFP 0.9614
126 4JP 0.9614
127 QWN 0.9610
128 5RG 0.9610
129 BAM 0.9608
130 5NU 0.9603
131 MZG 0.9603
132 XM0 0.9602
133 BE2 0.9601
134 4XR 0.9601
135 NOY 0.9599
136 4HC 0.9596
137 ES6 0.9596
138 IFL 0.9595
139 NIO 0.9594
140 NTN 0.9594
141 BSX 0.9593
142 AZ8 0.9593
143 24B 0.9593
144 4ZE 0.9592
145 HMU 0.9591
146 NBZ 0.9590
147 3U4 0.9589
148 QXW 0.9588
149 FBB 0.9587
150 5JC 0.9587
151 PE0 0.9586
152 K2T 0.9585
153 XBZ 0.9584
154 HHA 0.9582
155 PAB 0.9581
156 BCP 0.9579
157 5CU 0.9578
158 Q88 0.9578
159 3M0 0.9577
160 Q24 0.9575
161 4CS 0.9574
162 TDR 0.9572
163 MEW 0.9568
164 5MH 0.9568
165 M1Q 0.9567
166 8H8 0.9566
167 HBD 0.9564
168 ISZ 0.9563
169 EA1 0.9562
170 4CL 0.9562
171 3F0 0.9558
172 3HB 0.9558
173 J9W 0.9557
174 717 0.9556
175 PCA 0.9553
176 JBK 0.9553
177 GTQ 0.9553
178 MWJ 0.9553
179 4JJ 0.9552
180 1Y6 0.9552
181 WBU 0.9551
182 GAB 0.9551
183 HBA 0.9551
184 86J 0.9549
185 HQY 0.9548
186 0R0 0.9548
187 AC0 0.9548
188 M5K 0.9547
189 3AB 0.9546
190 KOJ 0.9545
191 NSP 0.9542
192 3NT 0.9542
193 2HQ 0.9541
194 LZM 0.9541
195 42A 0.9540
196 27Y 0.9540
197 5HN 0.9539
198 AQO 0.9537
199 2AC 0.9536
200 ZZT 0.9535
201 FE DB1 0.9532
202 2YU 0.9532
203 KJH 0.9530
204 FDB 0.9528
205 DBH 0.9527
206 SYV 0.9527
207 HPA 0.9526
208 5QX 0.9526
209 5SG 0.9525
210 TTL 0.9525
211 URC 0.9524
212 5Q0 0.9524
213 1SQ 0.9523
214 3HA 0.9523
215 A1U 0.9522
216 JZ3 0.9519
217 1WG 0.9517
218 4VP 0.9516
219 BR9 0.9516
220 KUF 0.9515
221 SRT 0.9512
222 G3F 0.9512
223 ES0 0.9512
224 CWM 0.9512
225 5IQ 0.9511
226 275 0.9511
227 BHO 0.9509
228 DOB 0.9509
229 VGL 0.9509
230 1LQ 0.9507
231 NIZ 0.9507
232 UNU 0.9506
233 ES1 0.9505
234 BTY 0.9505
235 4M0 0.9505
236 FPY 0.9504
237 AJ2 0.9502
238 FA0 0.9502
239 IFM 0.9500
240 3PF 0.9500
241 5QY 0.9498
242 BHA 0.9497
243 4JU 0.9497
244 AC6 0.9496
245 7W1 0.9495
246 HT4 0.9495
247 5UC 0.9494
248 PZA 0.9493
249 7B4 0.9493
250 5JQ 0.9492
251 PBC 0.9491
252 12Q 0.9490
253 2BG 0.9488
254 NMJ 0.9487
255 4YS 0.9486
256 OVV 0.9486
257 MLT 0.9486
258 XYD 0.9485
259 ADE 0.9485
260 N5J 0.9484
261 JZ7 0.9484
262 3OC 0.9483
263 FP1 0.9483
264 0P6 0.9483
265 53C 0.9481
266 2EC 0.9480
267 173 0.9480
268 R8S 0.9479
269 B55 0.9479
270 2CQ 0.9478
271 Z82 0.9477
272 FBM 0.9476
273 BTE 0.9476
274 ADZ 0.9475
275 JPZ 0.9474
276 54G 0.9474
277 PYD 0.9473
278 ICP 0.9473
279 BE7 0.9473
280 5M0 0.9472
281 A7W 0.9472
282 1WD 0.9472
283 QOS 0.9470
284 HQT 0.9469
285 75K 0.9469
286 CWS 0.9469
287 6CS 0.9469
288 24W 0.9469
289 OXZ 0.9467
290 PXL 0.9466
291 54D 0.9465
292 XYS 0.9465
293 7WA 0.9464
294 JZ2 0.9464
295 14J 0.9464
296 9MG 0.9464
297 MNN 0.9463
298 GCS 0.9462
299 34A 0.9461
300 8ZE 0.9459
301 M6N 0.9458
302 HSO 0.9457
303 L3Q 0.9457
304 G3E 0.9457
305 CTL 0.9457
306 2MH 0.9456
307 2MP 0.9454
308 JKE 0.9452
309 1NP 0.9451
310 DHB 0.9451
311 CFI 0.9450
312 4XH 0.9450
313 1DJ 0.9449
314 0TR 0.9449
315 TM7 0.9449
316 XIY 0.9448
317 FQI 0.9447
318 SS1 0.9446
319 826 0.9443
320 150 0.9443
321 23A 0.9442
322 10L 0.9440
323 O72 0.9440
324 3BZ 0.9439
325 PBZ 0.9439
326 QSC 0.9438
327 WCE 0.9435
328 HH8 0.9434
329 43M 0.9434
330 8CM 0.9433
331 B53 0.9433
332 XBT 0.9430
333 HIO 0.9429
334 SJ5 0.9426
335 4MA 0.9426
336 4HM 0.9426
337 P72 0.9425
338 Z6J 0.9424
339 VNJ 0.9423
340 THE 0.9423
341 174 0.9422
342 LG4 0.9422
343 G6D 0.9422
344 LT2 0.9421
345 J1Z 0.9421
346 6MP 0.9419
347 4ZC 0.9418
348 MNM 0.9417
349 9DA 0.9416
350 R8A 0.9415
351 KJU 0.9415
352 DIN 0.9414
353 5RN 0.9414
354 JBE 0.9413
355 I1E 0.9413
356 45C 0.9413
357 OXQ 0.9411
358 4P5 0.9409
359 MRW 0.9408
360 GBD 0.9407
361 8S0 0.9407
362 4YO 0.9407
363 PRO 0.9407
364 ES4 0.9406
365 SKA 0.9406
366 7WV 0.9405
367 XYL 0.9404
368 RB5 0.9404
369 HQE 0.9402
370 286 0.9401
371 PLQ 0.9401
372 CRS 0.9401
373 BP1 0.9400
374 BRT 0.9399
375 60P 0.9398
376 PM6 0.9398
377 7CZ 0.9398
378 7HP 0.9397
379 M1E 0.9396
380 NDH 0.9396
381 5MK 0.9396
382 AMC 0.9396
383 D48 0.9396
384 25W 0.9396
385 5GU 0.9394
386 MQN 0.9394
387 JBH 0.9394
388 4JO 0.9394
389 B57 0.9393
390 9HX 0.9391
391 FAN 0.9391
392 SE2 0.9391
393 QBK 0.9391
394 SHA 0.9390
395 1M2 0.9390
396 2D0 0.9390
397 5JL 0.9389
398 XAZ 0.9388
399 8TX 0.9387
400 3DM 0.9387
401 GAG 0.9385
402 CN0 0.9385
403 XQG 0.9384
404 SX1 0.9383
405 82I 0.9383
406 UGC 0.9381
407 BCU 0.9381
408 IUR 0.9381
409 PCR 0.9380
410 4JQ 0.9379
411 9TZ 0.9378
412 MXN 0.9378
413 4NC 0.9378
414 RSO 0.9378
415 1P3 0.9376
416 FBJ 0.9376
417 282 0.9376
418 7N0 0.9375
419 FOA 0.9375
420 JZ1 0.9374
421 LMR 0.9371
422 DA1 0.9371
423 2LP 0.9369
424 M58 0.9369
425 H8N 0.9369
426 GAL 0.9368
427 HY1 0.9367
428 3SK 0.9367
429 F9P 0.9365
430 HY3 0.9365
431 URP 0.9365
432 3XX 0.9365
433 F81 0.9364
434 TP5 0.9364
435 RCO 0.9363
436 FPI 0.9363
437 PYC 0.9361
438 FUL 0.9360
439 DFB 0.9360
440 RIB 0.9359
441 LGC 0.9359
442 SWD 0.9358
443 E5X 0.9357
444 P9P 0.9356
445 0JD 0.9355
446 FPN 0.9355
447 25R 0.9355
448 IDH 0.9354
449 DBJ 0.9354
450 8OZ 0.9354
451 SYN 0.9353
452 HIS 0.9352
453 PXY 0.9351
454 1DU 0.9349
455 EUG 0.9348
456 SMN 0.9348
457 INO 0.9345
458 JLZ 0.9345
459 TLA 0.9344
460 TAR 0.9344
461 J5I 0.9344
462 3MB 0.9344
463 JA8 0.9344
464 N2I 0.9344
465 PY7 0.9343
466 1LM 0.9341
467 EQT 0.9340
468 HBX 0.9340
469 RNS 0.9339
470 0TU 0.9339
471 8IG 0.9338
472 2ZM 0.9338
473 XX2 0.9336
474 RIP 0.9334
475 AGK 0.9332
476 3CH 0.9332
477 R8V 0.9332
478 GRE 0.9331
479 1LN 0.9330
480 TPA 0.9330
481 Y8I 0.9329
482 261 0.9327
483 4HS 0.9326
484 FCA 0.9325
485 PZI 0.9325
486 4JL 0.9325
487 DFU 0.9324
488 GYE 0.9324
489 WOO 0.9324
490 6RQ 0.9323
491 OVM 0.9323
492 5AC 0.9322
493 DRL 0.9322
494 ICO 0.9322
495 CWJ 0.9319
496 51R 0.9319
497 3NY 0.9318
498 NNO 0.9318
499 ZBT 0.9318
500 2A9 0.9317
501 2XX 0.9317
502 0MK 0.9315
503 F4Z 0.9314
504 6NT 0.9314
505 284 0.9314
506 KBG 0.9313
507 KDV 0.9312
508 MYJ 0.9312
509 URA 0.9312
510 FBA 0.9311
511 ABE 0.9311
512 IV2 0.9311
513 4AA 0.9310
514 AFR 0.9308
515 TIU 0.9308
516 ABN 0.9307
517 2PC 0.9307
518 PYG 0.9307
519 MO8 0.9306
520 0HO 0.9304
521 CYT 0.9304
522 DYA 0.9301
523 PYF 0.9301
524 BML 0.9300
525 ALL 0.9298
526 ARB 0.9297
527 KT7 0.9294
528 PKU 0.9294
529 4JM 0.9293
530 RNT 0.9293
531 HGQ 0.9293
532 OK7 0.9292
533 M2K 0.9292
534 9RW 0.9291
535 SW7 0.9291
536 6LW 0.9290
537 LDU 0.9289
538 MWP 0.9289
539 RMN 0.9289
540 2ZV 0.9289
541 IT2 0.9289
542 7VS 0.9289
543 LG3 0.9289
544 M0W 0.9288
545 3HM 0.9288
546 HX3 0.9287
547 G5V 0.9285
548 PHU 0.9285
549 4CH 0.9285
550 TC7 0.9285
551 6M1 0.9285
552 6F0 0.9284
553 HYP 0.9284
554 RHU 0.9284
555 EDG 0.9283
556 3Z7 0.9282
557 AZF 0.9280
558 EHM 0.9279
559 3Z8 0.9279
560 2HO 0.9277
561 4A3 0.9276
562 93K 0.9276
563 FHB 0.9276
564 JIF 0.9276
565 DBX 0.9275
566 BVF 0.9275
567 MZW 0.9275
568 GIF 0.9274
569 SOE 0.9273
570 FUC 0.9273
571 TLD 0.9273
572 ABI 0.9271
573 E7Z 0.9271
574 1F1 0.9270
575 5NI 0.9270
576 JBN 0.9270
577 QX2 0.9267
578 0W8 0.9267
579 DIE 0.9266
580 F0J 0.9266
581 DGJ 0.9264
582 HLZ 0.9264
583 TZC 0.9261
584 BNS 0.9260
585 4JN 0.9259
586 LG5 0.9259
587 PEA 0.9259
588 1XN 0.9258
589 PRY 0.9258
590 B62 0.9258
591 SWA 0.9257
592 265 0.9257
593 4M4 0.9255
594 6NI 0.9254
595 OW4 0.9251
596 PRS 0.9251
597 C21 0.9251
598 1MR 0.9250
599 PNZ 0.9249
600 3ZQ 0.9249
601 GXY 0.9248
602 PAF 0.9247
603 M0Q 0.9246
604 C2B 0.9246
605 9CL 0.9245
606 XUL 0.9245
607 2HU 0.9245
608 AZ9 0.9244
609 DHR 0.9244
610 26D 0.9244
611 JAW 0.9243
612 IF7 0.9241
613 7NI 0.9239
614 DMJ 0.9239
615 3A9 0.9238
616 94W 0.9237
617 F5B 0.9236
618 3RK 0.9236
619 KJY 0.9235
620 1DV 0.9235
621 PZM 0.9233
622 42C 0.9233
623 CTS 0.9233
624 HEW 0.9231
625 Q6T 0.9230
626 T6C 0.9230
627 1AB 0.9229
628 BDP 0.9224
629 B3R 0.9223
630 MBD 0.9222
631 QWW 0.9219
632 32X 0.9219
633 JZ4 0.9218
634 FCR 0.9216
635 XHP 0.9216
636 3WA 0.9216
637 3FH 0.9216
638 4FA 0.9216
639 MRZ 0.9214
640 PBA 0.9214
641 3FA 0.9214
642 J9T 0.9213
643 R2B 0.9212
644 9TW 0.9212
645 BDF 0.9211
646 IPB 0.9210
647 G4D 0.9210
648 7WG 0.9209
649 MUA 0.9208
650 CHB 0.9207
651 4NM 0.9205
652 UNC 0.9205
653 273 0.9205
654 P3K 0.9203
655 47J 0.9201
656 IOL 0.9200
657 JBQ 0.9199
658 6ME 0.9198
659 K34 0.9197
660 UY7 0.9193
661 35C 0.9193
662 QSB 0.9193
663 FBV 0.9192
664 M3T 0.9192
665 92K 0.9190
666 SMV 0.9189
667 ILE 0.9188
668 JZ5 0.9188
669 44V 0.9186
670 RBL 0.9186
671 MAE 0.9186
672 GOO 0.9185
673 6VD 0.9184
674 8WT 0.9184
675 DUC 0.9182
676 X05 0.9181
677 V55 0.9181
678 NQ 0.9181
679 44W 0.9181
680 7MU 0.9180
681 M2H 0.9178
682 DTL 0.9178
683 PA1 0.9177
684 ANN 0.9177
685 ASC 0.9175
686 CIG 0.9175
687 J9Q 0.9175
688 EXO 0.9174
689 ECE 0.9174
690 QX4 0.9174
691 TGX 0.9173
692 9R5 0.9172
693 GLF 0.9171
694 7MH 0.9171
695 HDH 0.9171
696 XXR 0.9171
697 3MC 0.9169
698 COI 0.9169
699 PRZ 0.9169
700 HQD 0.9169
701 4H2 0.9168
702 CAQ 0.9168
703 DHQ 0.9167
704 4WL 0.9166
705 AKH 0.9165
706 MS9 0.9165
707 2C9 0.9165
708 R9S 0.9165
709 H76 0.9164
710 TSU 0.9164
711 8GF 0.9163
712 948 0.9163
713 BEA 0.9163
714 4BZ 0.9161
715 64K 0.9159
716 MAN 0.9158
717 EKZ 0.9158
718 TSS 0.9157
719 VK3 0.9152
720 RXA 0.9152
721 2H5 0.9152
722 2CH 0.9152
723 AMH 0.9151
724 HHQ 0.9151
725 WOT 0.9150
726 HJP 0.9150
727 DPR 0.9150
728 15N 0.9150
729 IHB 0.9149
730 RAM 0.9149
731 TM4 0.9148
732 3CE 0.9147
733 JDN 0.9146
734 JAB 0.9146
735 OXC 0.9145
736 XRG 0.9145
737 GIO 0.9145
738 23W 0.9145
739 ASP 0.9145
740 2DR 0.9143
741 RPQ 0.9142
742 ALO 0.9142
743 GLA 0.9141
744 YHO 0.9141
745 MRY 0.9141
746 6MH 0.9141
747 OTW 0.9140
748 OXE 0.9140
749 DE5 0.9139
750 GMN 0.9139
751 3SL 0.9139
752 2MY 0.9138
753 AKG 0.9138
754 FFP 0.9137
755 N8Y 0.9137
756 PAC 0.9135
757 0FO 0.9135
758 LYL 0.9132
759 5RO 0.9132
760 9FL 0.9132
761 AEF 0.9132
762 259 0.9131
763 MAK 0.9130
764 B60 0.9130
765 2CM 0.9129
766 ODO 0.9129
767 2AK 0.9128
768 SHG 0.9127
769 DQU 0.9124
770 FH2 0.9123
771 OTR 0.9123
772 MVN 0.9123
773 BP9 0.9122
774 JB8 0.9122
775 8WO 0.9122
776 TEP 0.9121
777 BPN 0.9120
778 AAS 0.9118
779 HSE 0.9116
780 QY9 0.9116
781 PEL 0.9115
782 FLM 0.9115
783 M1H 0.9115
784 IMR 0.9114
785 YRL 0.9114
786 FUF 0.9113
787 2A7 0.9112
788 4Z4 0.9112
789 ICF 0.9111
790 280 0.9110
791 EYK 0.9109
792 GAF 0.9108
793 0N7 0.9107
794 TMZ 0.9107
795 KYD 0.9106
796 GCU 0.9106
797 HX2 0.9104
798 NBE 0.9103
799 XLS 0.9103
800 LDP 0.9103
801 GIV 0.9102
802 2FG 0.9102
803 L89 0.9102
804 51F 0.9101
805 BEW 0.9101
806 7ME 0.9099
807 OVP 0.9099
808 C2A 0.9099
809 TFB 0.9099
810 FB1 0.9099
811 6X8 0.9099
812 SAN 0.9096
813 ORO 0.9096
814 GLT 0.9094
815 OHG 0.9094
816 FOT 0.9093
817 X6X 0.9093
818 MAQ 0.9093
819 938 0.9093
820 1AN 0.9092
821 G3P 0.9091
822 G3H 0.9091
823 40O 0.9091
824 ZXD 0.9090
825 AHB 0.9090
826 37T 0.9090
827 HTS 0.9090
828 TEO 0.9089
829 2FY 0.9089
830 SPV 0.9088
831 AJV 0.9088
832 SD4 0.9087
833 4ZA 0.9086
834 5WX 0.9086
835 VNL 0.9085
836 PXM 0.9085
837 FUB 0.9085
838 1XX 0.9084
839 329 0.9083
840 KIV 0.9083
841 069 0.9082
842 FDK 0.9082
843 0LH 0.9082
844 HZQ 0.9080
845 CXF 0.9079
846 IP0 0.9079
847 8LG 0.9079
848 UEG 0.9078
849 DHK 0.9077
850 GXL 0.9077
851 495 0.9077
852 98J 0.9074
853 3R6 0.9074
854 UAN 0.9074
855 NDM 0.9073
856 ISE 0.9073
857 GLL 0.9072
858 JND 0.9071
859 SVD 0.9070
860 69O 0.9068
861 ARA 0.9068
862 S76 0.9067
863 ADK 0.9066
864 JFD 0.9066
865 DHS 0.9066
866 GJZ 0.9065
867 92Z 0.9064
868 268 0.9063
869 M4T 0.9062
870 MT0 0.9062
871 DUB 0.9062
872 TTY 0.9061
873 93Q 0.9060
874 HPY 0.9058
875 R9Y 0.9057
876 DIU 0.9057
877 4XX 0.9057
878 FCB 0.9056
879 97T 0.9056
880 1DQ 0.9056
881 FB2 0.9055
882 SS2 0.9054
883 12M 0.9054
884 4MU 0.9053
885 3MH 0.9053
886 FP2 0.9053
887 XCZ 0.9049
888 LKA 0.9048
889 MLA 0.9048
890 ASN 0.9045
891 FBW 0.9045
892 ICC 0.9042
893 PQ0 0.9042
894 FRU 0.9041
895 DOR 0.9037
896 PYQ 0.9037
897 39A 0.9037
898 2AF 0.9037
899 KPL 0.9035
900 C2U 0.9034
901 PBE 0.9033
902 SIN 0.9033
903 FUM 0.9033
904 149 0.9033
905 GLU 0.9031
906 76X 0.9030
907 INE 0.9029
908 LRH 0.9028
909 9X7 0.9028
910 BK9 0.9027
911 YTB 0.9026
912 3MA 0.9025
913 M3H 0.9024
914 BMA 0.9024
915 HSM 0.9024
916 NID 0.9023
917 JXN 0.9022
918 34D 0.9021
919 2AL 0.9021
920 9TY 0.9020
921 K5W 0.9020
922 F31 0.9020
923 3V4 0.9019
924 IFP 0.9019
925 RM4 0.9019
926 PFB 0.9019
927 PDC 0.9018
928 ARW 0.9017
929 PMB 0.9017
930 3IT 0.9015
931 A29 0.9014
932 L99 0.9014
933 YIO 0.9013
934 9CA 0.9013
935 0FN 0.9012
936 5WY 0.9011
937 MFB 0.9011
938 JZ0 0.9011
939 15E 0.9011
940 DMG 0.9009
941 4TU 0.9007
942 7ZE 0.9007
943 ZB1 0.9007
944 URQ 0.9007
945 PYJ 0.9006
946 SOR 0.9005
947 PRF 0.9004
948 X0V 0.9003
949 INS 0.9001
950 1SA 0.9001
951 TBP 0.9001
952 GDE 0.9001
953 DS0 0.8999
954 II6 0.8999
955 LNR 0.8998
956 APY 0.8997
957 2ZQ 0.8997
958 95Z 0.8996
959 SR1 0.8996
960 LSA 0.8993
961 ZWZ 0.8989
962 9YL 0.8989
963 DNF 0.8988
964 BZ2 0.8988
965 TBS 0.8985
966 SNE 0.8985
967 EVA 0.8985
968 AL0 0.8984
969 3MG 0.8983
970 T9G 0.8983
971 MLI 0.8982
972 H3M 0.8980
973 IJZ 0.8980
974 SXS 0.8980
975 1IT 0.8979
976 TMT 0.8979
977 9ZE 0.8977
978 NK2 0.8975
979 VOH 0.8975
980 QPR 0.8972
981 OA3 0.8972
982 SEJ 0.8971
983 LER 0.8969
984 E1T 0.8969
985 258 0.8968
986 SKM 0.8967
987 52C 0.8967
988 GZL 0.8964
989 4ME 0.8964
990 F12 0.8963
991 J6W 0.8963
992 APZ 0.8962
993 KP6 0.8961
994 SPA 0.8960
995 1GN 0.8960
996 SF9 0.8959
997 DEE 0.8958
998 2TQ 0.8956
999 ESP 0.8956
1000 ADA 0.8955
1001 6UA 0.8954
1002 AW5 0.8953
1003 N2Z 0.8953
1004 ITN 0.8952
1005 P2D 0.8952
1006 1U6 0.8952
1007 45L 0.8951
1008 TZE 0.8950
1009 B24 0.8950
1010 VAL 0.8949
1011 JFJ 0.8946
1012 FLA 0.8944
1013 PEP 0.8943
1014 HA5 0.8943
1015 K17 0.8942
1016 HA7 0.8941
1017 NEQ 0.8939
1018 FBS 0.8938
1019 4P0 0.8936
1020 HQJ 0.8936
1021 MZ0 0.8936
1022 FPK 0.8935
1023 RAT 0.8935
1024 HCS 0.8933
1025 HIU 0.8933
1026 M6W 0.8932
1027 4J8 0.8932
1028 CEJ 0.8932
1029 FK8 0.8930
1030 D1X 0.8930
1031 7VJ 0.8930
1032 5XB 0.8928
1033 PIY 0.8927
1034 25T 0.8927
1035 FBT 0.8926
1036 D07 0.8925
1037