Receptor
PDB id Resolution Class Description Source Keywords
4AHS 1.75 Å EC: 2.7.7.7 PARALLEL SCREENING OF A LOW MOLECULAR WEIGHT COMPOUND LIBRAR DIFFERENCES IN METHODOLOGY AFFECT HIT IDENTIFICATION HUMAN IMMUNODEFICIENCY VIRUS TRANSFERASE
Ref.: PARALLEL SCREENING OF LOW MOLECULAR WEIGHT FRAGMENT LIBRARIES: DO DIFFERENCES IN METHODOLOGY AFFECT HIT IDENTIFICATION? J.BIOMOL.SCREEN V. 18 147 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACT A:1213;
B:1213;
B:1214;
B:1215;
B:1216;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data
59.044 C2 H3 O2 CC(=O...
AKH A:1216;
B:1218;
Valid;
Valid;
none;
none;
submit data
162.142 C9 H6 O3 c1cc2...
EDO A:1214;
B:1217;
Invalid;
Invalid;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
GOL A:1215;
Invalid;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SO4 A:1211;
A:1212;
B:1211;
B:1212;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4E1N 2 Å EC: 2.7.7.7 CRYSTAL STRUCTURE OF HIV-1 INTEGRASE WITH A NON-CATAYLTIC SI INHIBITOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 HIV-1 INTEGRASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: NEW CLASS OF HIV-1 INTEGRASE (IN) INHIBITORS WITH A MODE OF ACTION. J.BIOL.CHEM. V. 287 21189 2012
Members (146)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 21 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
70% Homology Family (148)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
147 4E1M ic50 = 215 nM TQ2 C24 H27 N O3 Cc1ccc(cc1....
148 5HRN - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
50% Homology Family (148)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
147 4E1M ic50 = 215 nM TQ2 C24 H27 N O3 Cc1ccc(cc1....
148 5HRN - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: AKH; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 AKH 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: AKH; Similar ligands found: 1202
No: Ligand Similarity coefficient
1 Q6T 1.0000
2 7NI 0.9975
3 42C 0.9922
4 5WY 0.9879
5 2ZQ 0.9782
6 7ZE 0.9769
7 4ME 0.9762
8 HHA 0.9753
9 NID 0.9712
10 ICO 0.9712
11 3HA 0.9711
12 BGC 0.9707
13 UNC 0.9706
14 INE 0.9704
15 PDC 0.9693
16 FE DB1 0.9691
17 3F0 0.9690
18 QPR 0.9673
19 5RN 0.9673
20 G3F 0.9672
21 FOT 0.9672
22 HJP 0.9669
23 DBH 0.9661
24 3IT 0.9655
25 XQG 0.9651
26 HLZ 0.9643
27 EVA 0.9634
28 8XQ 0.9630
29 BDP 0.9628
30 7VS 0.9623
31 M1E 0.9622
32 GLC 0.9618
33 8S0 0.9609
34 7HQ 0.9609
35 M2K 0.9595
36 12B 0.9591
37 NTM 0.9586
38 I3A 0.9575
39 DBJ 0.9574
40 EA1 0.9574
41 GCS 0.9571
42 5RG 0.9571
43 G5V 0.9570
44 AZA 0.9570
45 6CS 0.9568
46 5M0 0.9568
47 IJZ 0.9566
48 NQ 0.9566
49 3M0 0.9565
50 JBK 0.9562
51 5WX 0.9562
52 XAN 0.9561
53 GUN 0.9560
54 VNL 0.9558
55 HNQ 0.9556
56 RXA 0.9552
57 LGC 0.9548
58 9DG 0.9543
59 92K 0.9534
60 GAL 0.9533
61 9TZ 0.9531
62 F12 0.9531
63 ORO 0.9530
64 M1H 0.9524
65 IGA 0.9524
66 GCU 0.9523
67 VK3 0.9511
68 LSA 0.9511
69 141 0.9510
70 APZ 0.9510
71 GTQ 0.9509
72 Z5P 0.9502
73 PYQ 0.9498
74 3MB 0.9496
75 AZ8 0.9494
76 O2A 0.9492
77 OXC 0.9492
78 C2U 0.9490
79 JKZ 0.9488
80 6AP 0.9484
81 XYP 0.9484
82 URC 0.9481
83 JBQ 0.9480
84 2LY 0.9476
85 GDE 0.9476
86 OVM 0.9475
87 M0Q 0.9474
88 A2F 0.9474
89 15L 0.9473
90 GCB 0.9473
91 4CS 0.9473
92 AZG 0.9472
93 1AL 0.9471
94 TTY 0.9471
95 NVU 0.9471
96 3HB 0.9470
97 CFP 0.9466
98 C2Y 0.9463
99 N5J 0.9463
100 TEP 0.9462
101 PE0 0.9457
102 MT0 0.9454
103 CCB 0.9451
104 495 0.9451
105 AJ2 0.9446
106 SAL 0.9446
107 6GU 0.9444
108 5Q0 0.9443
109 MHK 0.9441
110 IPZ 0.9441
111 GV9 0.9440
112 ES1 0.9439
113 KIB 0.9439
114 KBG 0.9438
115 5SG 0.9436
116 YSO 0.9435
117 TSR 0.9434
118 M5K 0.9434
119 M6N 0.9433
120 4HC 0.9433
121 IFM 0.9432
122 1NP 0.9432
123 3DO 0.9430
124 54G 0.9430
125 1LQ 0.9430
126 8TX 0.9427
127 9MG 0.9426
128 8GK 0.9426
129 AQO 0.9425
130 5IQ 0.9424
131 9KT 0.9424
132 4YS 0.9423
133 3WA 0.9421
134 DOR 0.9418
135 GOG 0.9417
136 1XM 0.9415
137 MT5 0.9412
138 HQY 0.9410
139 TVP 0.9409
140 HZQ 0.9408
141 SRO 0.9406
142 1SQ 0.9405
143 FBG 0.9404
144 BE2 0.9404
145 92P 0.9402
146 290 0.9401
147 JPZ 0.9400
148 DFB 0.9400
149 AIN 0.9399
150 MUA 0.9399
151 HXX 0.9399
152 B55 0.9398
153 37T 0.9397
154 MEW 0.9395
155 23J 0.9395
156 DNF 0.9394
157 RM1 0.9393
158 Q88 0.9392
159 3NT 0.9389
160 DX4 0.9389
161 OW4 0.9388
162 DNC 0.9388
163 G2F 0.9387
164 1XN 0.9386
165 24W 0.9385
166 34D 0.9384
167 23A 0.9384
168 GIO 0.9384
169 NTZ 0.9384
170 2AL 0.9382
171 8GC 0.9380
172 0CU 0.9379
173 NOJ 0.9376
174 12Q 0.9376
175 12M 0.9375
176 ZZ8 0.9374
177 SJ5 0.9374
178 D1X 0.9374
179 3MG 0.9373
180 Q24 0.9373
181 S76 0.9372
182 3MA 0.9371
183 CFF 0.9369
184 YH7 0.9368
185 NCD 0.9367
186 PXL 0.9367
187 GAB 0.9367
188 BTY 0.9367
189 AZ9 0.9367
190 JUG 0.9367
191 J9W 0.9366
192 PFB 0.9362
193 ADK 0.9362
194 ASO 0.9361
195 DRL 0.9360
196 A7W 0.9360
197 M1A 0.9359
198 OMD 0.9358
199 ISE 0.9358
200 TTL 0.9357
201 2D0 0.9355
202 AHR 0.9354
203 NOY 0.9351
204 4AA 0.9351
205 X09 0.9351
206 AW5 0.9351
207 BK9 0.9350
208 67N 0.9350
209 3AB 0.9348
210 5RO 0.9347
211 GYE 0.9344
212 DHK 0.9343
213 6F0 0.9342
214 3FH 0.9341
215 OVV 0.9341
216 GTR 0.9340
217 K5W 0.9340
218 BOA 0.9340
219 DIE 0.9339
220 GRE 0.9337
221 5MK 0.9336
222 4TU 0.9336
223 4SV 0.9333
224 KFH 0.9332
225 HPA 0.9328
226 6M4 0.9325
227 DIU 0.9323
228 NMJ 0.9323
229 1X7 0.9322
230 53C 0.9321
231 0P6 0.9320
232 PHT 0.9320
233 HLD 0.9319
234 UAN 0.9319
235 7W1 0.9319
236 M1Q 0.9317
237 ADE 0.9315
238 25W 0.9315
239 329 0.9312
240 LYL 0.9310
241 5QX 0.9310
242 XX2 0.9309
243 7WR 0.9309
244 II6 0.9308
245 5HN 0.9308
246 75K 0.9307
247 MRW 0.9307
248 HQT 0.9305
249 G1O 0.9305
250 HQD 0.9302
251 39A 0.9301
252 SHG 0.9300
253 KT7 0.9300
254 9DA 0.9299
255 G6D 0.9298
256 CWM 0.9298
257 B62 0.9297
258 4P0 0.9297
259 LZM 0.9294
260 42A 0.9294
261 ES0 0.9294
262 9HX 0.9294
263 GCW 0.9293
264 IFL 0.9292
265 4NC 0.9292
266 5OB 0.9292
267 BTE 0.9292
268 6MP 0.9291
269 BMA 0.9289
270 XAZ 0.9289
271 P3K 0.9288
272 IP0 0.9288
273 ADA 0.9284
274 PRZ 0.9282
275 MYJ 0.9282
276 FDB 0.9281
277 ES4 0.9281
278 0N7 0.9280
279 B60 0.9280
280 OXZ 0.9279
281 HH8 0.9279
282 261 0.9279
283 PD2 0.9278
284 DHB 0.9277
285 PM6 0.9275
286 BP1 0.9275
287 NFQ 0.9274
288 LCN 0.9274
289 6M1 0.9274
290 7HP 0.9274
291 LI6 0.9273
292 UEG 0.9273
293 KBB 0.9272
294 V55 0.9272
295 K3Q 0.9269
296 2MN 0.9269
297 0W8 0.9268
298 CWS 0.9266
299 INO 0.9266
300 8CM 0.9263
301 ES6 0.9263
302 4XH 0.9263
303 JKE 0.9263
304 SX1 0.9262
305 7WV 0.9262
306 X8D 0.9261
307 M0W 0.9260
308 0GZ 0.9259
309 KUF 0.9259
310 6BL 0.9257
311 2H5 0.9256
312 SYA 0.9254
313 HA7 0.9253
314 8IG 0.9253
315 10L 0.9253
316 8G0 0.9252
317 DIN 0.9252
318 D07 0.9252
319 CIT 0.9252
320 B57 0.9251
321 3OC 0.9248
322 ASC 0.9246
323 7WA 0.9246
324 3BZ 0.9242
325 QSH 0.9242
326 F0J 0.9240
327 2ZV 0.9239
328 3DM 0.9236
329 SKM 0.9236
330 BEA 0.9236
331 SHA 0.9235
332 FA0 0.9235
333 OW7 0.9233
334 5JQ 0.9233
335 3U4 0.9232
336 DOB 0.9231
337 4HM 0.9228
338 MO8 0.9228
339 IOS 0.9228
340 94B 0.9228
341 6VD 0.9228
342 RD4 0.9227
343 BHA 0.9227
344 TSS 0.9226
345 WCE 0.9225
346 MAQ 0.9225
347 0LH 0.9224
348 HH5 0.9224
349 PXM 0.9223
350 209 0.9223
351 2A7 0.9222
352 1WD 0.9222
353 5NS 0.9222
354 2LP 0.9221
355 NNO 0.9221
356 93K 0.9221
357 FLV 0.9221
358 DBX 0.9219
359 NDH 0.9215
360 2FG 0.9215
361 EYK 0.9215
362 2HO 0.9214
363 5CU 0.9214
364 ALL 0.9212
365 P9P 0.9212
366 MWP 0.9212
367 ADZ 0.9211
368 H33 0.9210
369 XHP 0.9209
370 JLZ 0.9209
371 E7Z 0.9208
372 BCP 0.9208
373 4M0 0.9208
374 AZF 0.9208
375 091 0.9208
376 SKA 0.9207
377 BRT 0.9207
378 226 0.9204
379 INS 0.9204
380 6ME 0.9203
381 LXC 0.9203
382 1LM 0.9201
383 GLT 0.9199
384 3NY 0.9198
385 SVN 0.9198
386 OTW 0.9196
387 0FO 0.9196
388 X05 0.9195
389 FHB 0.9194
390 32X 0.9194
391 4M4 0.9193
392 FP1 0.9193
393 KJH 0.9193
394 CHB 0.9193
395 B53 0.9193
396 44W 0.9191
397 PEY 0.9191
398 F31 0.9190
399 7B4 0.9189
400 KJY 0.9189
401 948 0.9188
402 R8S 0.9188
403 CN0 0.9186
404 4MU 0.9186
405 4A3 0.9185
406 OTD 0.9185
407 EUG 0.9184
408 3ID 0.9184
409 LKA 0.9183
410 MAN 0.9181
411 3AL 0.9181
412 5NE 0.9181
413 X6X 0.9180
414 PA1 0.9180
415 M4E 0.9179
416 149 0.9179
417 ZWZ 0.9178
418 CTS 0.9178
419 QSB 0.9178
420 82I 0.9176
421 FGZ 0.9176
422 KLW 0.9175
423 WOO 0.9171
424 5NU 0.9169
425 FH2 0.9167
426 A13 0.9167
427 0HO 0.9167
428 1GN 0.9165
429 BZX 0.9165
430 3HM 0.9164
431 IV2 0.9164
432 DMJ 0.9163
433 O72 0.9163
434 4ZC 0.9162
435 DQU 0.9161
436 5JL 0.9161
437 680 0.9161
438 GOX 0.9160
439 3Z8 0.9160
440 KYD 0.9158
441 3R6 0.9157
442 CTL 0.9155
443 C9E 0.9155
444 OVP 0.9155
445 GIV 0.9154
446 OA3 0.9154
447 J9T 0.9154
448 6NT 0.9154
449 GLA 0.9153
450 JBH 0.9153
451 PX7 0.9152
452 0HN 0.9152
453 JTH 0.9152
454 KYA 0.9150
455 SR4 0.9148
456 3SK 0.9148
457 67X 0.9146
458 44V 0.9144
459 NDM 0.9142
460 DHQ 0.9141
461 6DP 0.9140
462 SOE 0.9140
463 KKN 0.9140
464 FDK 0.9139
465 6XI 0.9138
466 60Q 0.9138
467 LDR 0.9138
468 FBT 0.9138
469 QAS 0.9138
470 BZ3 0.9137
471 NLA 0.9137
472 HFB 0.9137
473 TOF 0.9134
474 2EC 0.9134
475 MZB 0.9133
476 2AK 0.9130
477 4Z4 0.9129
478 G4D 0.9129
479 JIF 0.9128
480 ZVO 0.9128
481 FYU 0.9126
482 FBV 0.9126
483 F5B 0.9125
484 QMS 0.9124
485 SWA 0.9124
486 ENL 0.9123
487 EXO 0.9122
488 IAC 0.9122
489 TIU 0.9121
490 GTL 0.9120
491 9PY 0.9120
492 ISN 0.9120
493 SXS 0.9119
494 F81 0.9117
495 COU 0.9117
496 4XV 0.9116
497 9TW 0.9115
498 RPQ 0.9112
499 D3M 0.9111
500 SOR 0.9110
501 LZ2 0.9108
502 GJS 0.9108
503 QBK 0.9107
504 52C 0.9106
505 MNM 0.9106
506 03V 0.9106
507 GZL 0.9101
508 KIA 0.9099
509 TRA 0.9097
510 EQT 0.9097
511 BCF 0.9097
512 GZ8 0.9096
513 1P3 0.9095
514 9EW 0.9095
515 QAT 0.9095
516 K17 0.9095
517 MVN 0.9094
518 ZZ3 0.9094
519 1F1 0.9092
520 TAR 0.9090
521 FBU 0.9090
522 QX4 0.9090
523 RNS 0.9089
524 ARP 0.9089
525 AS3 0.9089
526 APS 0.9088
527 1P7 0.9088
528 6LW 0.9085
529 MSN 0.9085
530 DPZ 0.9085
531 I6G 0.9085
532 4FS 0.9083
533 3RK 0.9082
534 9AP 0.9081
535 MBG 0.9078
536 HA5 0.9077
537 IHB 0.9077
538 FB1 0.9077
539 2ZM 0.9076
540 SVD 0.9075
541 BBF 0.9075
542 XXR 0.9075
543 NGO 0.9074
544 VNJ 0.9074
545 DQN 0.9073
546 DMD 0.9073
547 GAF 0.9072
548 3Z7 0.9069
549 XQ0 0.9069
550 GM7 0.9068
551 KGK 0.9065
552 M5N 0.9065
553 0F9 0.9064
554 2AQ 0.9064
555 NGT 0.9063
556 R8V 0.9063
557 GLF 0.9063
558 2DR 0.9062
559 B2J 0.9061
560 GXL 0.9061
561 6R8 0.9061
562 069 0.9061
563 JBE 0.9061
564 293 0.9059
565 3PF 0.9059
566 5XC 0.9058
567 OCH 0.9058
568 MVL 0.9057
569 86J 0.9057
570 FUL 0.9057
571 PZI 0.9056
572 TBS 0.9055
573 IBF 0.9055
574 F05 0.9053
575 YIO 0.9051
576 QUZ 0.9051
577 IPB 0.9051
578 4JT 0.9050
579 N7P 0.9050
580 JB5 0.9049
581 L7T 0.9049
582 14O 0.9049
583 6M9 0.9048
584 YQA 0.9048
585 ZB1 0.9047
586 7FF 0.9046
587 QM1 0.9046
588 CLZ 0.9045
589 PQK 0.9045
590 FRU 0.9045
591 EJZ 0.9045
592 3XX 0.9045
593 7VJ 0.9044
594 HIO 0.9044
595 9KH 0.9043
596 QIC 0.9043
597 4XS 0.9042
598 2KA 0.9042
599 ZXD 0.9042
600 5WV 0.9042
601 GTZ 0.9041
602 2FQ 0.9041
603 JZ3 0.9041
604 5WU 0.9039
605 8VN 0.9039
606 4KL 0.9039
607 5H1 0.9039
608 2K4 0.9038
609 H42 0.9037
610 06B 0.9036
611 R9S 0.9035
612 ES5 0.9035
613 ONR 0.9034
614 EOL 0.9034
615 BNT 0.9034
616 GT0 0.9033
617 6NI 0.9033
618 N8P 0.9032
619 KOJ 0.9031
620 3RI 0.9030
621 BPU 0.9030
622 ABI 0.9030
623 GIM 0.9030
624 HMU 0.9030
625 1DW 0.9029
626 0RW 0.9028
627 FBW 0.9028
628 JR2 0.9027
629 PHH 0.9027
630 XYL 0.9026
631 RB5 0.9026
632 173 0.9026
633 PCI 0.9026
634 51R 0.9025
635 7MH 0.9024
636 FLC 0.9023
637 G3E 0.9022
638 5NI 0.9021
639 F60 0.9021
640 NK 0.9019
641 VXX 0.9019
642 28N 0.9019
643 7W4 0.9017
644 MJ2 0.9017
645 6AI 0.9015
646 9FL 0.9015
647 UFO 0.9013
648 HTP 0.9012
649 ZON 0.9012
650 AJV 0.9010
651 AFR 0.9009
652 XYS 0.9009
653 GLY PRO 0.9009
654 5MI 0.9007
655 HMH 0.9006
656 LT2 0.9005
657 NPY 0.9004
658 TAG 0.9004
659 5MB 0.9003
660 GOO 0.9003
661 ES7 0.9000
662 SRT 0.9000
663 4XR 0.8998
664 7CT 0.8996
665 H6B 0.8995
666 97T 0.8995
667 FA3 0.8994
668 N8Y 0.8994
669 18N 0.8994
670 GIF 0.8992
671 FUC 0.8992
672 PFL 0.8991
673 KTA 0.8991
674 286 0.8990
675 HLR 0.8990
676 0JD 0.8988
677 BR8 0.8988
678 GCV 0.8987
679 AUD 0.8986
680 FHN 0.8985
681 EV0 0.8985
682 7B3 0.8983
683 MS9 0.8983
684 2HU 0.8983
685 QX2 0.8983
686 QWW 0.8979
687 MIG 0.8978
688 XCZ 0.8978
689 RIB 0.8978
690 AGK 0.8978
691 8WT 0.8978
692 TFU 0.8975
693 BSX 0.8975
694 5B1 0.8975
695 4SX 0.8975
696 MR1 0.8974
697 DQA 0.8973
698 SWD 0.8973
699 UFV 0.8970
700 ES9 0.8969
701 0R0 0.8969
702 3C2 0.8968
703 3A9 0.8965
704 2HQ 0.8964
705 7ME 0.8963
706 MQB 0.8963
707 4AV 0.8962
708 AEZ 0.8962
709 ZYR 0.8962
710 DEE 0.8961
711 VOH 0.8961
712 8OZ 0.8961
713 1QP 0.8960
714 8HC 0.8960
715 45L 0.8960
716 M3Q 0.8959
717 TWO 0.8959
718 8ZE 0.8957
719 V6F 0.8956
720 MT8 0.8955
721 SYV 0.8955
722 FBB 0.8954
723 XXP 0.8953
724 GCO 0.8953
725 463 0.8952
726 8WO 0.8951
727 6UA 0.8951
728 3C1 0.8950
729 ABV 0.8950
730 TRC 0.8949
731 N2Z 0.8949
732 PRF 0.8949
733 5QY 0.8948
734 2SX 0.8947
735 SE2 0.8946
736 24B 0.8946
737 JAE 0.8945
738 2FY 0.8942
739 2TQ 0.8940
740 7MU 0.8940
741 2D3 0.8939
742 H4N 0.8938
743 JAW 0.8935
744 57O 0.8935
745 TLA 0.8934
746 11S 0.8934
747 AX2 0.8934
748 BCU 0.8933
749 1P8 0.8933
750 ODO 0.8933
751 RSF 0.8933
752 IFP 0.8932
753 T6C 0.8932
754 AX7 0.8931
755 PQ0 0.8930
756 M6Z 0.8929
757 Q7A 0.8929
758 15N 0.8927
759 270 0.8927
760 J5I 0.8926
761 1PT 0.8925
762 FK1 0.8924
763 HQJ 0.8923
764 MBD 0.8923
765 H7Y 0.8921
766 L3Q 0.8920
767 R8A 0.8920
768 0MK 0.8919
769 64C 0.8918
770 RMN 0.8918
771 HKD 0.8918
772 EMZ 0.8916
773 A29 0.8916
774 F69 0.8915
775 DGJ 0.8913
776 ICT 0.8910
777 ET2 0.8910
778 F3B 0.8909
779 LNR 0.8906
780 39U 0.8906
781 2A9 0.8904
782 RAM 0.8904
783 ZZT 0.8903
784 13X 0.8903
785 HIS 0.8903
786 BEZ 0.8900
787 LDP 0.8900
788 F9Y 0.8898
789 EKZ 0.8898
790 KJU 0.8897
791 D48 0.8897
792 SF9 0.8896
793 KP6 0.8894
794 Q71 0.8893
795 NCA 0.8893
796 RM4 0.8891
797 1U1 0.8891
798 7A3 0.8891
799 XM0 0.8891
800 3AY 0.8891
801 8H8 0.8890
802 CBF 0.8889
803 QWN 0.8889
804 JFD 0.8888
805 39O 0.8887
806 N2I 0.8887
807 GAG 0.8887
808 RIP 0.8887
809 2CL 0.8887
810 BEN 0.8886
811 AH8 0.8885
812 K2P 0.8884
813 2CK 0.8883
814 X0V 0.8883
815 VGD 0.8883
816 5ZE 0.8882
817 ALA PRO 0.8881
818 FPK 0.8881
819 BDF 0.8881
820 JFJ 0.8880
821 7D2 0.8877
822 0FK 0.8876
823 LFR 0.8874
824 K2T 0.8874
825 JND 0.8873
826 PH2 0.8872
827 AY4 0.8872
828 HQ9 0.8870
829 MMA 0.8870
830 XQK 0.8870
831 SR1 0.8869
832 DNA 0.8868
833 NIO 0.8868
834 5AN 0.8868
835 60P 0.8867
836 95Z 0.8866
837 47J 0.8863
838 C2A 0.8863
839 NIZ 0.8862
840 ARB 0.8858
841 NPO 0.8857
842 BAM 0.8856
843 P92 0.8856
844 MB1 0.8855
845 JB8 0.8855
846 ES2 0.8855
847 9FE 0.8854
848 30G 0.8854
849 8XL 0.8852
850 4FH 0.8851
851 J01 0.8850
852 PYG 0.8849
853 3FA 0.8849
854 3CE 0.8847
855 6PC 0.8846
856 ERH 0.8846
857 JZ4 0.8845
858 PRY 0.8844
859 FXH 0.8843
860 LT8 0.8842
861 4JQ 0.8842
862 JDN 0.8841
863 LAO 0.8841
864 8VE 0.8840
865 W81 0.8837
866 MFB 0.8837
867 2CM 0.8837
868 1LN 0.8836
869 K8X 0.8835
870 IF7 0.8834
871 MCT 0.8834
872 36R 0.8833
873 8NY 0.8833
874 9CA 0.8832
875 PBA 0.8832
876 AMG 0.8832
877 5GU 0.8831
878 FUF 0.8829
879 E1T 0.8829
880 PEZ 0.8828
881 FEH 0.8827
882 2PG 0.8827
883 1WG 0.8827
884 LT3 0.8826
885 XSP 0.8826
886 CLW 0.8825
887 2C9 0.8825
888 J9Q 0.8824
889 K32 0.8824
890 6OT 0.8823
891 GMN 0.8823
892 QUS 0.8822
893 JXN 0.8821
894 2ZX 0.8821
895 OXQ 0.8821
896 NBZ 0.8821
897 HX3 0.8820
898 UNU 0.8820
899 FCB 0.8818
900 JZ1 0.8818
901 UQ 0.8817
902 URF 0.8817
903 GBD 0.8816
904 I1N 0.8814
905 1WC 0.8813
906 5AC 0.8812
907 49O 0.8811
908 1U6 0.8810
909 20J 0.8809
910 6MH 0.8808
911 61M 0.8807
912 YCP 0.8807
913 3TJ 0.8806
914 5CL 0.8805
915 2MI 0.8804
916 K22 0.8804
917 MWM 0.8804
918 PHU 0.8803
919 QXW 0.8803
920 PZA 0.8802
921 PHB 0.8800
922 GXY 0.8800
923 JXZ 0.8798
924 NSP 0.8798
925 TH7 0.8798
926 WDL 0.8796
927 B5D 0.8795
928 DUB 0.8795
929 FAN 0.8795
930 EDR 0.8794
931 MFU 0.8794
932 6JN 0.8794
933 5VJ 0.8793
934 4ZE 0.8793
935 7N0 0.8792
936 FDR 0.8791
937 URQ 0.8791
938 H76 0.8790
939 TZE 0.8788
940 5VM 0.8788
941 W8G 0.8788
942 1IT 0.8786
943 4YO 0.8786
944 CKU 0.8785
945 3GQ 0.8785
946 ROI 0.8785
947 PAB 0.8785
948 DHS 0.8780
949 64K 0.8779
950 2CQ 0.8779
951 RHU 0.8779
952 NTN 0.8776
953 2MY 0.8774
954 CFI 0.8774
955 K6X 0.8773
956 AX3 0.8772
957 0FN 0.8772
958 RSO 0.8772
959 REL 0.8770
960 CWJ 0.8769
961 4AN 0.8769
962 5OF 0.8768
963 790 0.8767
964 DEN 0.8766
965 4HO 0.8765
966 JA8 0.8764
967 FA6 0.8764
968 MQN 0.8761
969 N3W 0.8761
970 AC6 0.8761
971 6RQ 0.8760
972 8WZ 0.8760
973 HY3 0.8760
974 G12 0.8759
975 PBC 0.8758
976 TM4 0.8757
977 H62 0.8756
978 BHO 0.8756
979 FUD 0.8755
980 FBM 0.8753
981 KDF 0.8753
982 DRG 0.8753
983 M2H 0.8753
984 BNS 0.8753
985 2CG 0.8752
986 8W9 0.8752
987 WBU 0.8752
988 3R9 0.8751
989 M3S 0.8750
990 0TU 0.8750
991 BSP 0.8748
992 150 0.8748
993 HHT 0.8747
994 CDV 0.8747
995 XXG 0.8747
996 2YU 0.8747
997 PJW 0.8746
998 ATH 0.8745
999 IBM 0.8745
1000 QSC 0.8745
1001 PAC 0.8745
1002 BZF 0.8745
1003 FLM 0.8743
1004 9ZE 0.8741
1005 PSV 0.8741
1006 TDR 0.8741
1007 260 0.8741
1008 P72 0.8740
1009 ESI 0.8740
1010 6KX 0.8739
1011 XBZ 0.8739
1012 XIY 0.8739
1013 IND 0.8739
1014 FA1 0.8738
1015 0RN 0.8738
1016 9UL 0.8737
1017 NEQ 0.8737
1018 HHR 0.8734
1019 DHY 0.8734
1020 JG8 0.8733
1021 R9Y 0.8733
1022 ICP 0.8733
1023 3MC 0.8732
1024 2AC 0.8732
1025 TBP 0.8732
1026 VGL 0.8731
1027 OHP 0.8728
1028 7I2 0.8727
1029 4P5 0.8727
1030 BZI 0.8727
1031 DA4 0.8726
1032 FCA 0.8726
1033 9R5 0.8725