Receptor
PDB id Resolution Class Description Source Keywords
4CJV 1.95 Å EC: 2.7.7.7 INTERROGATING HIV INTEGRASE FOR COMPOUNDS THAT BIND- A SAMPL CHALLENGE HUMAN IMMUNODEFICIENCY VIRUS 1 TRANSFERASE STRUCTURE BASED DRUG DESIGN
Ref.: INTERROGATING HIV INTEGRASE FOR COMPOUNDS THAT BIND SAMPL CHALLENGE. J.COMPUT.AIDED MOL.DES. V. 28 347 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GOL B:1214;
A:1211;
Invalid;
Invalid;
none;
none;
submit data
92.094 C3 H8 O3 C(C(C...
SO4 B:1209;
A:1210;
B:1210;
A:1209;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
IV2 B:1215;
A:1212;
Valid;
Valid;
none;
none;
submit data
198.673 C8 H7 Cl N2 S Cc1c(...
ACT B:1211;
B:1213;
B:1212;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
59.044 C2 H3 O2 CC(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4E1N 2 Å EC: 2.7.7.7 CRYSTAL STRUCTURE OF HIV-1 INTEGRASE WITH A NON-CATAYLTIC SI INHIBITOR HUMAN IMMUNODEFICIENCY VIRUS TYPE 1 HIV-1 INTEGRASE TRANSFERASE-TRANSFERASE INHIBITOR COMPLEX
Ref.: NEW CLASS OF HIV-1 INTEGRASE (IN) INHIBITORS WITH A MODE OF ACTION. J.BIOL.CHEM. V. 287 21189 2012
Members (146)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 21 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
70% Homology Family (148)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
147 4E1M ic50 = 215 nM TQ2 C24 H27 N O3 Cc1ccc(cc1....
148 5HRN - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
50% Homology Family (148)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 20 families.
1 4CJU - JNS C16 H12 O4 c1ccc(cc1)....
2 6VLM ic50 = 10 uM R2D C17 H11 Cl N2 O2 S c1ccc2c(c1....
3 4CEB Kd = 1080 uM ZSV C32 H35 N2 O8 COc1ccc(cc....
4 3AVG - ALA ASP LYS ILE ASP ASN LEU ASP n/a n/a
5 4CIE - Y7N C24 H26 N2 O5 c1ccc2c(c1....
6 4LH5 ic50 = 0.23 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
7 5OI8 ic50 = 0.21 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
8 3NFA - CBJ C18 H12 Br N O6 c1cc2c(cc1....
9 3ZSZ - OM2 C22 H27 N2 O5 CC[C@H](C)....
10 4DMN ic50 = 2.3 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
11 3L3V - GLC FRU n/a n/a
12 4CJL - 9PA C20 H30 N2 O5 CC(C)C[C@@....
13 3AVA ic50 = 39.7 uM ALA LEU LYS ILE ASP ASN LEU ASP n/a n/a
14 4CF0 - O5U C28 H34 N2 O7 c1ccc2c(c1....
15 4AHT - Q6T C8 H6 O4 c1cc(c2c(c....
16 4O5B - LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
17 4CER - VL4 C27 H32 N2 O7 CN(Cc1cccc....
18 4CFA - WOP C26 H25 N3 O6 CN(Cc1ccc2....
19 4CJT - HLR C7 H6 N2 O c1ccc2c(c1....
20 4CJ3 - E4F C23 H26 N2 O5 c1ccc2c(c1....
21 4CGF - UJ6 C17 H13 N O5 c1ccc2c(c1....
22 4CJF - RVN C17 H11 N O5 c1ccc2c(c1....
23 5KGW - 7SK C24 H27 N O4 CC(C)(C)O[....
24 3ZSW - ZSW C28 H35 N2 O7 CC[C@@H](C....
25 4O55 ic50 = 5.03 uM LF9 C26 H26 Cl N3 O3 Cc1c(c(c(n....
26 4E1N ic50 = 19 nM TQX C26 H28 F N O4 Cc1c(cc(c2....
27 4CEO - G0T C30 H32 N2 O8 CN(Cc1cccc....
28 3NF7 ic50 = 340 uM CIW C17 H12 Cl N O5 c1cc2c(cc1....
29 3AO2 Kd = 0.17 mM AVX C11 H10 Br N3 O2 Cn1c(cc(n1....
30 3ZT4 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
31 4OVL - 1TD C16 H11 N O3 c1ccc2c(c1....
32 5KRS - 6XI C9 H7 N O2 S c1ccn(c1)c....
33 3AVN - SER HIS LYS ILE ASP ASN LEU ASP n/a n/a
34 4CHY - C5Q C17 H13 N O4 c1ccc2c(c1....
35 3ZSR - O3N C31 H38 N2 O7 C=CCN(Cc1c....
36 4CGI Kd = 752 uM NZL C24 H28 N2 O5 c1ccc2c(c1....
37 3VQE - FMQ C11 H11 F N2 O Cc1c(cnn1c....
38 3AVI - SER LEU LYS ILE ASP ASN MET ASP n/a n/a
39 3VQP - DBJ C9 H10 O3 c1cc(c2c(c....
40 4CK2 - NVU C9 H7 N O3 c1ccc2c(c1....
41 4CJW - CBJ C18 H12 Br N O6 c1cc2c(cc1....
42 3VQ7 - GLC FRU n/a n/a
43 6NCJ ic50 = 0.024 uM KJJ C35 H41 F N2 O4 Cc1c(cc(c2....
44 4CES - NFW C27 H28 N2 O8 CN(Cc1cccc....
45 4CF2 - 3GM C26 H30 N2 O7 c1ccc2c(c1....
46 3AVH - ALA ARG LYS ILE ASP ASN LEU ASP n/a n/a
47 3ZSX - N44 C27 H25 N2 O5 C=CCN(Cc1c....
48 3AVC - SER ASP LYS ILE ASP ASN LEU ASP n/a n/a
49 4O0J ic50 = 13 uM LF8 C27 H30 Cl N O3 Cc1ccc(cc1....
50 3AVM - SER ARG LYS ILE ASP ASN LEU ASP n/a n/a
51 4AHU - ICO C9 H7 N O2 c1ccc2c(c1....
52 5KRT - 6W6 C9 H5 Cl2 N O2 S c1cc(n(c1C....
53 3AVB ic50 = 85.2 uM SER LEU LYS ILE ASP ASN LEU ASP n/a n/a
54 4CJR Kd = 793 uM FYM C27 H28 N2 O7 CN(Cc1cccc....
55 4AHS - AKH C9 H6 O3 c1cc2ccoc2....
56 4CIF - JDX C26 H28 N2 O5 CN(Cc1cccc....
57 3VQ6 - BCK C11 H12 N2 O Cn1c(c(cn1....
58 3ZT0 Kd = 595 nM ZT0 C26 H27 N2 O6 C[NH+](Cc1....
59 3AO5 Kd = 5.9 mM BBY C11 H10 Br N3 O2 Cn1c(cc(n1....
60 4NYF Kd = 49 nM 4BI C22 H22 Cl N O3 Cc1c(c(c2c....
61 4CK3 Kd = 268 uM K1T C19 H28 N2 O5 CC(C)C[C@@....
62 4CEE - B0T C26 H32 N2 O7 CC[C@H](C)....
63 4AH9 - 0MB C13 H16 N4 S c1ccc(cc1)....
64 4TSX Kd = 10.3 uM LF0 C25 H27 N O4 Cc1c(c(c2c....
65 4CJQ Kd = 256 uM VXO C25 H28 N2 O5 CC(C)C[C@@....
66 5OI5 ic50 = 0.19 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
67 1HYZ ic50 = 380 uM TTO C24 H20 As O2 c1ccc(cc1)....
68 4CF1 - IY7 C27 H32 N2 O7 c1ccc2c(c1....
69 4CE9 - O3N C31 H38 N2 O7 C=CCN(Cc1c....
70 3AO4 Kd = 8.5 mM 833 C11 H11 N3 O2 Cn1c(cc(n1....
71 3ZT2 Kd = 1375 uM ZT2 C18 H12 O5 c1ccc2c(c1....
72 4CFB - OM3 C25 H31 N2 O5 C[N@H+](Cc....
73 3VQD - MOK C11 H9 N O3 Cc1c(c(no1....
74 4CHP - IMV C17 H13 N O5 c1ccc2c(c1....
75 3ZT1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
76 3VQ9 - FBB C7 H5 F N2 S c1cc2c(cc1....
77 3VQC - MPK C11 H11 N O2 Cc1c(c(no1....
78 3ZSV - ZSV C32 H35 N2 O8 COc1ccc(cc....
79 4CJP - 4D2 C21 H24 N2 O5 CC(C)C[C@@....
80 4CGG - K5Q C22 H19 N O7 c1ccc2c(c1....
81 6NUJ - L3D C27 H26 N2 O4 Cc1c(c(c2c....
82 4CFC - 7NV C23 H27 N3 O6 CCCCNC(=O)....
83 4CEF - D0T C29 H30 N2 O7 CN(Cc1cccc....
84 3AO1 Kd = 5.5 mM BZX C7 H6 O3 c1cc2c(cc1....
85 3ZT3 Kd = 1435 uM ZT4 C18 H14 O5 c1ccc2c(c1....
86 4CHO - U2Z C12 H15 N3 O Cc1cc(nn1c....
87 3NF9 ic50 = 290 uM CD9 C17 H12 Cl N O5 c1cc2c(cc1....
88 1HYV ic50 > 5 mM TTA C24 H20 As c1ccc(cc1)....
89 3ZSQ Kd = 10.9 uM O4N C31 H34 N2 O6 CCC[C@@H](....
90 4CGD - 8P3 C16 H13 N O3 c1ccc2c(c1....
91 4CF9 - 5EY C22 H20 O7 c1ccc2c(c1....
92 3AVK - SER LEU LYS ILE ASP ASN GLU ASP n/a n/a
93 4CEC - 2SS C29 H34 N2 O7 C=CCN(Cc1c....
94 4CHQ - CWU C18 H16 O5 c1ccc2c(c1....
95 5HRR - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
96 4CGJ - NZL C24 H28 N2 O5 c1ccc2c(c1....
97 3VQB - FBG C9 H7 F O4 c1c(cc(c2c....
98 4GVM ic50 = 1.49 uM LF2 C22 H21 Br Cl N O3 Cc1c(c(c2c....
99 3VQQ - BTE C6 H5 N3 S c1cc(c2c(c....
100 3AVJ - ALA LEU LYS ILE ASP ASN MET ASP n/a n/a
101 4CFD - S8Y C23 H27 N3 O6 CC(C)(C)NC....
102 4JLH ic50 = 15.6 uM 0L9 C19 H15 Br Cl N O3 Cc1c(c(c2c....
103 4CJK - H39 C21 H26 N2 O5 CC(C)C[C@@....
104 4CF8 - V7H C28 H28 N2 O7 c1ccc(cc1)....
105 4CK1 - OM1 C25 H25 N2 O6 COc1ccc(cc....
106 4CHN - ONZ C10 H9 N O5 c1cc(c2c(c....
107 4OJR - 2SQ C26 H28 F N O5 Cc1c(cc(c2....
108 4ID1 - LF0 C25 H27 N O4 Cc1c(c(c2c....
109 6UM8 Ki = 0.17 uM QCG C29 H30 F N3 O4 Cc1c(cc(c2....
110 3VQ8 - BCU C10 H12 O2 c1ccc2c(c1....
111 6LMI - EJ9 C32 H39 N O6 S Cc1ccc(cc1....
112 3OVN Kd = 2.8 mM MPV C8 H9 N3 S Cn1c(cc(n1....
113 3VQ4 - 0NX C10 H9 N O2 c1ccc(cc1)....
114 4CHZ - H75 C13 H13 Br N2 O c1cc(ccc1N....
115 1QS4 ic50 = 2.3 uM 100 C12 H8 Cl N5 O2 c1cc2c(cc1....
116 4CIG Kd = 214 uM X0P C30 H30 N2 O5 CN(Cc1cccc....
117 6EB1 ic50 = 4.65 uM J3M C30 H29 N O4 CC(C)(C)O[....
118 5HRS - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
119 3AV9 ic50 = 435 uM SER ALA LYS ILE ASP ASN LEU ASP n/a n/a
120 4CED - 9NS C29 H30 N2 O8 C=CCN(Cc1c....
121 4CEZ - O3N C31 H38 N2 O7 C=CCN(Cc1c....
122 4AHR - I2E C10 H10 O4 c1cc2c(cc1....
123 3ZSO Kd = 7.6 uM O2N C35 H34 N2 O7 COc1ccc(cc....
124 5HRP - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
125 3AO3 - BMC C12 H10 N2 O4 Cn1c(cc(n1....
126 5OI2 ic50 = 0.17 uM 9VN C24 H31 N O3 S Cc1c(c(c(s....
127 4CJ4 Kd = 432 uM S3G C21 H24 N2 O5 CC(C)C[C@@....
128 4CJS - L0Y C26 H32 N2 O5 CN(Cc1cccc....
129 3ZCM Kd = 519 uM PX3 C28 H28 N2 O6 COc1ccc(cc....
130 3NF6 ic50 = 295 uM IMV C17 H13 N O5 c1ccc2c(c1....
131 4CEA - ZSW C28 H35 N2 O7 CC[C@@H](C....
132 4CJE - Q31 C20 H25 N3 O5 CC(C)C[C@@....
133 4CJ5 Kd = 200 uM 4VW C22 H26 N2 O5 CC(C)C[C@@....
134 3AVL ic50 = 65.8 uM ALA THR LYS ILE ASP ASN LEU ASP n/a n/a
135 4CGH - LOZ C22 H24 N2 O5 c1ccc2c(c1....
136 6LMQ - 940 C31 H38 N2 O6 S Cc1ccc(cc1....
137 3NF8 - CDQ C18 H14 Cl N O5 c1cc2c(cc1....
138 3VQA - MWP C8 H7 N O2 S c1cc2c(cc1....
139 6EB2 ic50 = 0.48 uM J3P C34 H33 N3 O4 CC(C)(C)O[....
140 4CJV - IV2 C8 H7 Cl N2 S Cc1c(ccc2c....
141 3AVF ic50 = 295 uM ASP LEU LYS ILE ASP ASN LEU ASP n/a n/a
142 5OIA ic50 = 0.17 uM 9VK C24 H31 N O3 S Cc1c(c(c(s....
143 3ZSY - OM3 C25 H31 N2 O5 C[N@H+](Cc....
144 4CEQ - QCH C29 H36 N2 O7 CN(Cc1cccc....
145 3VQ5 - MMJ C12 H14 N2 S Cc1c(sc(n1....
146 4AHV - Z5P C10 H11 N3 c1ccc(c(c1....
147 4E1M ic50 = 215 nM TQ2 C24 H27 N O3 Cc1ccc(cc1....
148 5HRN - 65P C31 H32 F2 N2 O4 Cc1c(ccc2c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: IV2; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 IV2 1 1
2 2D0 0.4375 0.888889
Similar Ligands (3D)
Ligand no: 1; Ligand: IV2; Similar ligands found: 1211
No: Ligand Similarity coefficient
1 TTL 0.9830
2 SKA 0.9798
3 7W1 0.9773
4 GCS 0.9773
5 G3F 0.9765
6 BGC 0.9752
7 5QX 0.9718
8 HQT 0.9714
9 12Q 0.9712
10 8S0 0.9679
11 0P6 0.9676
12 CWS 0.9672
13 86J 0.9665
14 8CM 0.9659
15 GLC 0.9658
16 VGD 0.9654
17 JA8 0.9649
18 1P8 0.9648
19 KUF 0.9641
20 ES2 0.9639
21 67N 0.9626
22 PXL 0.9617
23 CLW 0.9596
24 2HQ 0.9589
25 5VM 0.9588
26 CWM 0.9575
27 36R 0.9572
28 SYV 0.9571
29 ET2 0.9569
30 ES0 0.9561
31 Q88 0.9557
32 M1A 0.9554
33 APZ 0.9554
34 AZ9 0.9551
35 H42 0.9544
36 R8V 0.9539
37 03V 0.9534
38 DIN 0.9530
39 BDP 0.9527
40 75K 0.9526
41 4FS 0.9526
42 MS9 0.9524
43 GDE 0.9524
44 K2T 0.9523
45 COU 0.9523
46 A7W 0.9520
47 VK3 0.9519
48 HQD 0.9518
49 FBB 0.9513
50 XAZ 0.9513
51 CTL 0.9512
52 GAL 0.9508
53 ES5 0.9505
54 JB5 0.9505
55 2AQ 0.9500
56 4AA 0.9500
57 URC 0.9500
58 NOJ 0.9499
59 KJU 0.9493
60 MRW 0.9491
61 ODO 0.9489
62 24W 0.9488
63 N8Y 0.9485
64 0N7 0.9484
65 B55 0.9481
66 NQ 0.9476
67 BTY 0.9470
68 RXA 0.9470
69 5JQ 0.9468
70 5JL 0.9461
71 OCH 0.9459
72 209 0.9458
73 GTQ 0.9455
74 1SQ 0.9452
75 KT7 0.9450
76 MQN 0.9449
77 8TX 0.9446
78 3Z8 0.9446
79 B57 0.9445
80 BEA 0.9442
81 54G 0.9439
82 5WV 0.9437
83 5M0 0.9435
84 1NP 0.9434
85 37T 0.9430
86 1LQ 0.9430
87 5RG 0.9427
88 SHG 0.9427
89 H33 0.9426
90 GCU 0.9426
91 J9Q 0.9421
92 ABV 0.9420
93 2H5 0.9419
94 ES1 0.9415
95 5GU 0.9414
96 LGC 0.9413
97 0FN 0.9410
98 DHK 0.9410
99 O72 0.9409
100 2FQ 0.9409
101 FDB 0.9408
102 5Q0 0.9407
103 PQ0 0.9406
104 5SG 0.9406
105 5IQ 0.9406
106 KKN 0.9406
107 5QY 0.9405
108 HQY 0.9404
109 6RQ 0.9404
110 G6D 0.9402
111 RM1 0.9402
112 M2K 0.9398
113 5XC 0.9397
114 1P7 0.9392
115 4M0 0.9392
116 SHA 0.9390
117 4YS 0.9389
118 94W 0.9388
119 CWJ 0.9387
120 7HQ 0.9386
121 M6N 0.9386
122 INE 0.9385
123 5MK 0.9384
124 I3A 0.9384
125 EA1 0.9384
126 8ZE 0.9383
127 8WT 0.9381
128 NDH 0.9380
129 ISN 0.9380
130 JPZ 0.9378
131 97T 0.9377
132 8IG 0.9374
133 ZYR 0.9373
134 3PF 0.9372
135 92K 0.9371
136 3HA 0.9371
137 PHB 0.9371
138 AX7 0.9370
139 N2I 0.9369
140 G3E 0.9369
141 9R5 0.9369
142 4NC 0.9368
143 3F0 0.9368
144 N5J 0.9366
145 15L 0.9366
146 5NU 0.9366
147 4XH 0.9365
148 HDH 0.9365
149 DOB 0.9364
150 R9Y 0.9364
151 2FY 0.9361
152 8WO 0.9360
153 4JQ 0.9358
154 OTW 0.9356
155 SX1 0.9355
156 0TU 0.9354
157 HH8 0.9352
158 39O 0.9352
159 SKM 0.9351
160 6CS 0.9350
161 ES7 0.9348
162 BZ3 0.9347
163 FGZ 0.9347
164 11S 0.9346
165 INO 0.9345
166 FA0 0.9344
167 4MU 0.9344
168 LDP 0.9342
169 XHP 0.9341
170 F81 0.9340
171 5B1 0.9340
172 Q24 0.9338
173 MEW 0.9337
174 8W9 0.9337
175 BHA 0.9336
176 5CU 0.9336
177 QBK 0.9336
178 25W 0.9336
179 NID 0.9334
180 23A 0.9334
181 XYP 0.9334
182 QWW 0.9334
183 4ME 0.9333
184 LKA 0.9333
185 3HM 0.9332
186 NAG 0.9332
187 P92 0.9330
188 P9P 0.9330
189 DQU 0.9329
190 DHB 0.9329
191 ICO 0.9329
192 B62 0.9329
193 3DM 0.9327
194 44W 0.9326
195 2MI 0.9326
196 270 0.9326
197 AQO 0.9325
198 5OB 0.9324
199 GTR 0.9324
200 9FL 0.9322
201 4XV 0.9321
202 7W4 0.9319
203 0FO 0.9319
204 2HO 0.9318
205 4FA 0.9318
206 TTY 0.9317
207 KDV 0.9316
208 AZ8 0.9316
209 D48 0.9316
210 JAE 0.9313
211 4XS 0.9313
212 JLZ 0.9312
213 SOE 0.9312
214 BZX 0.9311
215 NNO 0.9310
216 5RN 0.9310
217 GLA 0.9310
218 XX2 0.9309
219 XQ0 0.9309
220 M5K 0.9306
221 6ME 0.9306
222 B53 0.9305
223 HBD 0.9305
224 FK1 0.9304
225 J5I 0.9304
226 XIY 0.9303
227 AJV 0.9301
228 ES9 0.9301
229 495 0.9300
230 NPO 0.9300
231 4A3 0.9298
232 LZM 0.9298
233 TH7 0.9297
234 M1Q 0.9296
235 93K 0.9294
236 LI6 0.9294
237 DHR 0.9294
238 149 0.9294
239 FHB 0.9293
240 AJ2 0.9293
241 GZL 0.9292
242 H4N 0.9290
243 5MI 0.9289
244 TEP 0.9289
245 DNF 0.9288
246 SE2 0.9288
247 F60 0.9287
248 173 0.9287
249 K32 0.9286
250 9KT 0.9286
251 E7Z 0.9285
252 J6W 0.9284
253 F9Y 0.9283
254 2K4 0.9283
255 3M0 0.9283
256 1M2 0.9282
257 0HO 0.9282
258 K22 0.9281
259 1KP 0.9281
260 42A 0.9280
261 4YO 0.9280
262 7VS 0.9279
263 DMD 0.9279
264 5RO 0.9279
265 1Y6 0.9277
266 HZQ 0.9276
267 3ID 0.9276
268 CLZ 0.9275
269 KJY 0.9275
270 MYJ 0.9274
271 PYQ 0.9274
272 PE0 0.9274
273 5H1 0.9273
274 MT0 0.9272
275 14O 0.9272
276 CHB 0.9272
277 EVA 0.9270
278 MUA 0.9268
279 G5V 0.9267
280 LXC 0.9266
281 PEY 0.9264
282 HMH 0.9264
283 2BG 0.9264
284 4MA 0.9264
285 TOF 0.9263
286 E7S 0.9263
287 DBH 0.9262
288 1IT 0.9262
289 9CA 0.9262
290 4HC 0.9261
291 PAB 0.9261
292 AHR 0.9261
293 0HN 0.9259
294 SOR 0.9259
295 15E 0.9258
296 FE DB1 0.9257
297 NIZ 0.9257
298 PBZ 0.9255
299 PH2 0.9255
300 GIV 0.9255
301 4TU 0.9253
302 6NT 0.9253
303 MVN 0.9252
304 ADE 0.9252
305 J9W 0.9250
306 MR1 0.9250
307 VXX 0.9250
308 6AI 0.9249
309 4Z4 0.9249
310 8NY 0.9249
311 1F1 0.9249
312 3IT 0.9248
313 CH9 0.9248
314 5MB 0.9247
315 2AK 0.9247
316 Z82 0.9247
317 KJH 0.9246
318 92P 0.9242
319 AC6 0.9242
320 6VD 0.9242
321 SWA 0.9242
322 Q6T 0.9241
323 UAN 0.9241
324 174 0.9241
325 HX3 0.9241
326 UFO 0.9241
327 DPZ 0.9240
328 4JT 0.9240
329 HPA 0.9239
330 261 0.9239
331 OTR 0.9236
332 826 0.9235
333 FP1 0.9234
334 CFI 0.9233
335 IHB 0.9232
336 0JD 0.9232
337 FYU 0.9230
338 C2Y 0.9230
339 VNL 0.9230
340 15N 0.9230
341 7NI 0.9229
342 NPY 0.9229
343 10L 0.9226
344 1GN 0.9226
345 1A7 0.9225
346 PNZ 0.9224
347 AZA 0.9222
348 PRF 0.9221
349 ANN 0.9221
350 HHA 0.9220
351 QUZ 0.9220
352 9TW 0.9219
353 QSH 0.9218
354 QX4 0.9218
355 1PT 0.9218
356 ISZ 0.9217
357 4XR 0.9216
358 BHO 0.9214
359 2LY 0.9212
360 B60 0.9211
361 BTE 0.9210
362 7WA 0.9210
363 30G 0.9210
364 6MP 0.9207
365 GUN 0.9207
366 6AP 0.9205
367 0FK 0.9204
368 44V 0.9204
369 ASO 0.9204
370 PZI 0.9204
371 GJP 0.9203
372 5NI 0.9203
373 1DW 0.9203
374 5WY 0.9203
375 TSS 0.9203
376 MSR 0.9203
377 EXO 0.9202
378 8HC 0.9201
379 2EC 0.9200
380 HIS 0.9200
381 V55 0.9199
382 82I 0.9197
383 42C 0.9196
384 4RU 0.9196
385 XQG 0.9195
386 PDC 0.9194
387 1HN 0.9193
388 DRL 0.9191
389 4HM 0.9191
390 9TZ 0.9190
391 2HU 0.9187
392 BE2 0.9187
393 27B 0.9186
394 XM0 0.9185
395 A29 0.9183
396 SAL 0.9183
397 HHR 0.9182
398 9MG 0.9182
399 MAQ 0.9181
400 JTH 0.9181
401 Z5P 0.9180
402 KYA 0.9179
403 KOJ 0.9178
404 AEF 0.9178
405 ESI 0.9177
406 4M4 0.9177
407 GCB 0.9176
408 2FG 0.9176
409 9DA 0.9175
410 SW7 0.9175
411 LT2 0.9175
412 FDR 0.9174
413 P3K 0.9173
414 39A 0.9170
415 XAN 0.9170
416 CTS 0.9170
417 2ZQ 0.9168
418 F12 0.9166
419 1XM 0.9165
420 6KT 0.9165
421 AKH 0.9164
422 CFF 0.9164
423 HLZ 0.9163
424 HJP 0.9161
425 YRL 0.9160
426 E1T 0.9158
427 2ZM 0.9158
428 7HP 0.9158
429 BP1 0.9158
430 ES4 0.9158
431 3NY 0.9157
432 7ZE 0.9156
433 FOT 0.9155
434 M0Q 0.9154
435 G2F 0.9151
436 PFB 0.9150
437 GIO 0.9150
438 52C 0.9150
439 3A9 0.9148
440 JBQ 0.9147
441 9DG 0.9145
442 6NI 0.9144
443 2AL 0.9144
444 0W8 0.9144
445 JAW 0.9143
446 NDM 0.9143
447 MBG 0.9141
448 28N 0.9140
449 F0J 0.9139
450 9HX 0.9136
451 YH7 0.9134
452 MWP 0.9134
453 K17 0.9134
454 EQT 0.9133
455 BOA 0.9132
456 7B4 0.9131
457 M4E 0.9130
458 I1E 0.9129
459 PM6 0.9129
460 ABI 0.9126
461 6GU 0.9126
462 ES6 0.9125
463 3R6 0.9124
464 CFP 0.9124
465 A2F 0.9123
466 141 0.9122
467 XXR 0.9122
468 OVM 0.9121
469 3U4 0.9121
470 4SV 0.9121
471 8H8 0.9121
472 FLV 0.9120
473 IPB 0.9120
474 226 0.9120
475 3MG 0.9120
476 3WA 0.9119
477 TGX 0.9119
478 4P5 0.9119
479 HBA 0.9118
480 MAN 0.9116
481 7MX 0.9116
482 SLS 0.9115
483 NTZ 0.9115
484 GRE 0.9112
485 ORO 0.9111
486 2A9 0.9110
487 NOY 0.9108
488 3MB 0.9107
489 2KA 0.9105
490 1XN 0.9104
491 0F9 0.9104
492 DFB 0.9103
493 BCU 0.9102
494 2CK 0.9101
495 EMZ 0.9100
496 N3W 0.9100
497 4CS 0.9100
498 680 0.9099
499 SXS 0.9099
500 BK9 0.9096
501 IGA 0.9096
502 7VJ 0.9096
503 MO8 0.9095
504 PHU 0.9095
505 UNC 0.9095
506 GXL 0.9095
507 TPA 0.9095
508 7WR 0.9094
509 BPN 0.9093
510 AJY 0.9090
511 TYL 0.9090
512 DBX 0.9089
513 QWN 0.9088
514 JIF 0.9088
515 5WX 0.9087
516 GVG 0.9084
517 F05 0.9083
518 BZ2 0.9081
519 X6X 0.9081
520 GYE 0.9081
521 32X 0.9078
522 ADZ 0.9077
523 SNU 0.9077
524 AZG 0.9076
525 HQJ 0.9076
526 0CU 0.9075
527 IJZ 0.9074
528 LNR 0.9074
529 QPR 0.9074
530 GM7 0.9073
531 R8S 0.9073
532 FUD 0.9073
533 KTW 0.9072
534 HKD 0.9072
535 GAF 0.9072
536 6PC 0.9072
537 SVN 0.9071
538 4KL 0.9071
539 PA1 0.9071
540 JDN 0.9070
541 FBM 0.9070
542 JG8 0.9070
543 9ZE 0.9070
544 GJS 0.9069
545 3FH 0.9069
546 M1H 0.9069
547 GXY 0.9067
548 HH5 0.9067
549 7MU 0.9066
550 9EW 0.9064
551 DX4 0.9063
552 5VL 0.9063
553 IFP 0.9061
554 QXW 0.9060
555 DBJ 0.9060
556 TBS 0.9060
557 6M9 0.9060
558 BPY 0.9058
559 0RW 0.9056
560 JUG 0.9056
561 BCP 0.9056
562 DEE 0.9056
563 6M1 0.9056
564 KIB 0.9055
565 KIA 0.9055
566 ADA 0.9055
567 8GC 0.9054
568 RHU 0.9054
569 LYL 0.9053
570 BEZ 0.9053
571 OXC 0.9052
572 CPZ 0.9051
573 X05 0.9050
574 EUG 0.9049
575 WOO 0.9048
576 NMJ 0.9047
577 BAM 0.9047
578 PKU 0.9046
579 SRO 0.9045
580 EYK 0.9044
581 290 0.9044
582 PXM 0.9044
583 QAT 0.9042
584 LDR 0.9041
585 4BL 0.9041
586 E5X 0.9041
587 JFJ 0.9040
588 IFL 0.9039
589 HMU 0.9039
590 F9P 0.9039
591 2K8 0.9039
592 UNJ 0.9038
593 BEN 0.9038
594 717 0.9037
595 K3Q 0.9037
596 4VP 0.9036
597 8OZ 0.9036
598 ISE 0.9036
599 J9T 0.9033
600 X0V 0.9033
601 42J 0.9032
602 DGJ 0.9032
603 ESP 0.9032
604 DHQ 0.9031
605 ZZT 0.9030
606 BSX 0.9028
607 68A 0.9028
608 PBA 0.9028
609 HLR 0.9027
610 G12 0.9027
611 UFV 0.9027
612 WCE 0.9027
613 NCA 0.9024
614 V1T 0.9023
615 9FE 0.9022
616 FDK 0.9022
617 PHH 0.9021
618 JFD 0.9021
619 FH2 0.9021
620 C2U 0.9020
621 7B3 0.9019
622 4BY 0.9019
623 TZF 0.9019
624 PD2 0.9018
625 9AP 0.9018
626 K97 0.9018
627 3AB 0.9018
628 PJW 0.9016
629 HA5 0.9016
630 7MH 0.9015
631 YIO 0.9014
632 IAC 0.9014
633 428 0.9014
634 34D 0.9011
635 L99 0.9010
636 K5W 0.9009
637 4WL 0.9009
638 AN3 0.9009
639 JKE 0.9008
640 TT4 0.9008
641 3QV 0.9008
642 D1X 0.9008
643 6F0 0.9005
644 JBE 0.9005
645 8NX 0.9005
646 XYS 0.9005
647 PRZ 0.9004
648 S76 0.9004
649 NSP 0.9003
650 YCP 0.9003
651 3HB 0.9002
652 OW4 0.9002
653 ICB 0.9001
654 ALL 0.9001
655 6FZ 0.9001
656 GZ8 0.9000
657 12B 0.9000
658 AW5 0.8999
659 AA 0.8999
660 PX7 0.8998
661 5CL 0.8997
662 OVV 0.8997
663 3ZB 0.8997
664 TWO 0.8997
665 DEN 0.8997
666 FAN 0.8996
667 GF4 0.8995
668 FUL 0.8995
669 KBG 0.8993
670 3NT 0.8993
671 4NM 0.8993
672 T6C 0.8992
673 7WV 0.8991
674 12T 0.8990
675 7ME 0.8990
676 J9N 0.8990
677 PIM 0.8990
678 2LP 0.8989
679 DIE 0.8989
680 N7I 0.8989
681 DMJ 0.8988
682 EKZ 0.8988
683 2F6 0.8988
684 069 0.8987
685 FA3 0.8984
686 GAB 0.8982
687 JZ3 0.8982
688 4SX 0.8982
689 3RK 0.8982
690 EV0 0.8981
691 1WG 0.8980
692 DRG 0.8979
693 4BZ 0.8979
694 2ZV 0.8976
695 8G0 0.8975
696 5HN 0.8973
697 F4E 0.8973
698 K37 0.8972
699 1WD 0.8972
700 4ZC 0.8971
701 53C 0.8970
702 BZJ 0.8968
703 UNU 0.8968
704 NIO 0.8967
705 H8N 0.8967
706 2GS 0.8964
707 PEA 0.8964
708 NVU 0.8963
709 24B 0.8963
710 DOR 0.8962
711 YPN 0.8961
712 ADK 0.8960
713 QAS 0.8960
714 DNC 0.8960
715 AC0 0.8960
716 RAM 0.8959
717 F31 0.8958
718 XBZ 0.8958
719 EN1 0.8958
720 IF7 0.8956
721 OMD 0.8956
722 5NE 0.8956
723 QIC 0.8956
724 PIY 0.8956
725 6TZ 0.8956
726 8XQ 0.8954
727 MCT 0.8953
728 Q71 0.8951
729 GOO 0.8951
730 259 0.8950
731 E3D 0.8950
732 HNQ 0.8949
733 6M4 0.8949
734 ANF 0.8949
735 PBC 0.8949
736 URF 0.8947
737 INS 0.8946
738 QX2 0.8945
739 BZI 0.8945
740 ONR 0.8944
741 1QP 0.8943
742 TH0 0.8943
743 IDM 0.8943
744 4ZA 0.8942
745 NK 0.8941
746 3R4 0.8941
747 3XX 0.8941
748 NBZ 0.8941
749 2A7 0.8940
750 GLT 0.8940
751 1LM 0.8939
752 G1O 0.8938
753 JBK 0.8938
754 4JM 0.8938
755 3Z7 0.8937
756 L5V 0.8936
757 IND 0.8936
758 AMG 0.8935
759 GNM 0.8933
760 PYD 0.8933
761 JBH 0.8932
762 1MC 0.8932
763 4HO 0.8932
764 SNO 0.8931
765 X09 0.8930
766 X0U 0.8930
767 PQK 0.8930
768 OVP 0.8929
769 LSA 0.8928
770 R9S 0.8928
771 ESX 0.8927
772 1AL 0.8926
773 4ZE 0.8926
774 I3E 0.8926
775 BZF 0.8925
776 3DO 0.8925
777 AX3 0.8925
778 DIU 0.8924
779 G4D 0.8924
780 23J 0.8924
781 BDF 0.8923
782 JB8 0.8922
783 KYD 0.8922
784 2CQ 0.8921
785 4FH 0.8921
786 GV9 0.8920
787 BRT 0.8920
788 MZG 0.8920
789 293 0.8918
790 IFM 0.8917
791 3OC 0.8917
792 EGR 0.8916
793 TSU 0.8916
794 3BZ 0.8915
795 D07 0.8914
796 PZA 0.8913
797 DHY 0.8913
798 5LA 0.8911
799 LZ1 0.8911
800 UEG 0.8911
801 X8D 0.8910
802 K6X 0.8910
803 A1U 0.8908
804 2AC 0.8907
805 XXP 0.8907
806 4CL 0.8906
807 IWT 0.8906
808 HXX 0.8906
809 4VY 0.8906
810 4JJ 0.8905
811 QOS 0.8905
812 W81 0.8904
813 0R1 0.8903
814 F5B 0.8902
815 M5H 0.8902
816 MWJ 0.8901
817 3MA 0.8900
818 OA3 0.8900
819 LCN 0.8899
820 H5B 0.8899
821 THA 0.8899
822 BMA 0.8899
823 NCT 0.8898
824 A7H 0.8897
825 OXZ 0.8897
826 SS1 0.8897
827 5TY 0.8896
828 VGL 0.8896
829 ASC 0.8894
830 JZ2 0.8894
831 DNA 0.8893
832 JU2 0.8893
833 K8X 0.8891
834 ZVO 0.8890
835 275 0.8888
836 MWM 0.8888
837 A5E 0.8888
838 K34 0.8888
839 NDG 0.8888
840 6BL 0.8887
841 NTN 0.8886
842 AAS 0.8886
843 A65 0.8886
844 AMH 0.8885
845 EJZ 0.8884
846 XYD 0.8884
847 27Y 0.8883
848 H7Y 0.8880
849 MPI 0.8879
850 RPQ 0.8879
851 5JC 0.8879
852 GOX 0.8879
853 FCR 0.8878
854 FUC 0.8877
855 45L 0.8877
856 8XL 0.8876
857 4JL 0.8876
858 150 0.8874
859 RIB 0.8874
860 34A 0.8873
861 HHS 0.8873
862 EOL 0.8871
863 2HC 0.8871
864 H4E 0.8870
865 2YU 0.8870
866 P72 0.8868
867 WBU 0.8868
868 BR9 0.8868
869 I6G 0.8866
870 2MP 0.8864
871 GVH 0.8864
872 36Y 0.8864
873 BSP 0.8863
874 OAA 0.8862
875 O2A 0.8861
876 TDR 0.8861
877 KTJ 0.8861
878 RB5 0.8860
879 1XA 0.8860
880 BPU 0.8859
881 ZZ8 0.8858
882 RM4 0.8858
883 SAN 0.8858
884 N2Z 0.8855
885 TBP 0.8854
886 MFB 0.8854
887 344 0.8852
888 B5D 0.8852
889 4J8 0.8851
890 PAC 0.8850
891 43M 0.8850
892 R8A 0.8849
893 20J 0.8849
894 SJ5 0.8848
895 PZM 0.8848
896 MAJ 0.8847
897 C2B 0.8846
898 BCF 0.8844
899 ZZZ 0.8843
900 DQN 0.8843
901 YSO 0.8841
902 57O 0.8841
903 0R0 0.8840
904 NGO 0.8840
905 0BP 0.8838
906 12M 0.8837
907 GO2 0.8837
908 GCO 0.8835
909 HT4 0.8834
910 OK7 0.8832
911 0CT 0.8830
912 PFL 0.8830
913 TIU 0.8829
914 BBF 0.8829
915 IBF 0.8828
916 ICP 0.8827
917 VNJ 0.8825
918 RMN 0.8824
919 5MH 0.8823
920 4JO 0.8823
921 QSB 0.8823
922 GBD 0.8822
923 5UC 0.8822
924 7D2 0.8822
925 PHT 0.8821
926 JF2 0.8821
927 XYL 0.8819
928 54X 0.8819
929 45C 0.8818
930 ARB 0.8818
931 AY4 0.8817
932 RNS 0.8817
933 Q02 0.8817
934 HFB 0.8815
935 0XT 0.8813
936 YQA 0.8813
937 NTM 0.8812
938 5NS 0.8812
939 0W1 0.8811
940 ZXD 0.8810
941 FBS 0.8809
942 DQA 0.8809
943 MLT 0.8809
944 HBO 0.8807
945 KGK 0.8807
946 4NB 0.8806
947 HTP 0.8804
948 JF1 0.8803
949 R20 0.8803
950 DX3 0.8801
951 TM7 0.8800
952 C9E 0.8799
953 FBA 0.8799
954 1U6 0.8798
955 VOH 0.8797
956 MPV 0.8797
957 ZBT 0.8797
958 FBT 0.8796
959 MVL 0.8796
960 KLW 0.8795
961 EXD 0.8795
962 BIK 0.8793
963 FCB 0.8793
964 FA1 0.8793
965 EPR 0.8793
966 GIF 0.8792
967 RD4 0.8792
968 FRU 0.8792
969 OGA 0.8792
970 FQI 0.8790
971 RSO 0.8790
972 CXF 0.8789
973 OXQ 0.8788
974 4JC 0.8787
975 CKA 0.8786
976 9PY 0.8786
977 MNM 0.8784
978 RNO 0.8783
979 14J 0.8783
980 ROI 0.8782
981 HA7 0.8781
982 FBV 0.8780
983 GIM 0.8780
984 JZ9 0.8780
985 SYA 0.8780
986 ZB1 0.8780
987 SRT 0.8777
988 CXH 0.8777
989 Y8I 0.8776
990 60P 0.8773
991 6QF 0.8773
992 36E 0.8773
993 OQC 0.8773
994 TC7 0.8772
995 4VS 0.8772
996 M1E 0.8771
997 XRG 0.8771
998 IUR 0.8770
999 06B 0.8770
1000 GAG 0.8770
1001 286 0.8770
1002 DYA 0.8770
1003 L7T 0.8766
1004 AZF 0.8766
1005 PCI 0.8765
1006 F4Z 0.8762
1007 Q7A 0.8761
1008 M3H 0.8761
1009 BNL 0.8761
1010 AIN 0.8761
1011 ZZ3 0.8760
1012 ZWZ 0.8760
1013 OW7 0.8760
1014 K25 0.8760
1015 D3M 0.8760
1016 1P3 0.8760
1017 0TR 0.8759
1018 QSC 0.8759
1019 IOS 0.8758
1020 JP2 0.8757
1021 GDL 0.8757
1022 8NB 0.8756
1023 MT5 0.8756
1024 AGK 0.8755
1025 B56 0.8753
1026 HX4 0.8751
1027 7I2 0.8750
1028 HLD 0.8749
1029 JYB 0.8749
1030 KBB 0.8748
1031 F3B 0.8746
1032 4I8 0.8746
1033 CK2 0.8746
1034 FB1 0.8744
1035 3SK 0.8743
1036 6E8