Receptor
PDB id Resolution Class Description Source Keywords
4H9G 1.93 Å EC: 3.6.5.3 PROBING EF-TU WITH A VERY SMALL BROMINATED FRAGMENT LIBRARY THE CCA POCKET THERMUS THERMOPHILUS P-LOOP GTPASE GTP BINDING TRNA BINDING RIBOSOME BINDINGTRANSLATION
Ref.: IDENTIFYING LIGAND-BINDING HOT SPOTS IN PROTEINS US BROMINATED FRAGMENTS. ACTA CRYSTALLOGR.,SECT.F V. 69 1060 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
GNP A:501;
Valid;
none;
submit data
522.196 C10 H17 N6 O13 P3 c1nc2...
SO4 A:510;
A:505;
A:511;
A:504;
A:506;
A:507;
A:509;
A:508;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
none;
submit data
96.063 O4 S [O-]S...
MG A:502;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
14J A:512;
Valid;
none;
submit data
190.98 C5 H3 Br O3 c1cc(...
NH4 A:503;
Invalid;
none;
submit data
18.038 H4 N [NH4+...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2C78 1.4 Å EC: 3.6.5.3 EF-TU COMPLEXED WITH A GTP ANALOG AND THE ANTIBIOTIC PULVOMY THERMUS THERMOPHILUS HYDROLASE GTPASE TRANSLATION ELONGATION FACTOR PROTEIN SYANTIBIOTIC GTP-BINDING NUCLEOTIDE-BINDING PHOSPHORYLATIOPROTEIN BIOSYNTHESIS ELONGATION FACTOR
Ref.: STRUCTURAL BASIS OF THE ACTION OF PULVOMYCIN AND GE ELONGATION FACTOR TU. BIOCHEMISTRY V. 45 6846 2006
Members (9)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 4H9G - 14J C5 H3 Br O3 c1cc(oc1C(....
2 4LBZ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
3 4LC0 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
4 1EXM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
5 2C78 - PUL C47 H66 O13 C[C@@H]1[C....
6 1EFT - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 4LBV - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 4LBW - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 1HA3 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
70% Homology Family (18)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 1D2E Kd = 1 uM GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 5W76 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 5W7Q - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
4 1DG1 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
5 2BVN - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
6 1EFC - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
7 6EZE - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
8 4H9G - 14J C5 H3 Br O3 c1cc(oc1C(....
9 4LBZ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
10 4LC0 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
11 1EXM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
12 2C78 - PUL C47 H66 O13 C[C@@H]1[C....
13 1EFT - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
14 4LBV - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
15 4LBW - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
16 1HA3 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
17 4J0Q - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
18 5W75 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
50% Homology Family (15)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 220 families.
1 5W76 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
2 5W7Q - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
3 4H9G - 14J C5 H3 Br O3 c1cc(oc1C(....
4 4LBZ - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
5 4LC0 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
6 1EXM - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
7 2C78 - PUL C47 H66 O13 C[C@@H]1[C....
8 1EFT - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
9 4LBV - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
10 4LBW - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
11 1HA3 - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
12 4J0Q - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
13 1SKQ - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
14 1JNY - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
15 3WYA - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GNP; Similar ligands found: 129
No: Ligand ECFP6 Tc MDL keys Tc
1 9GM 1 1
2 GNP 1 1
3 GDP 0.839506 0.973684
4 GP3 0.82716 0.948718
5 GTP 0.809524 0.973684
6 GNH 0.807229 0.986842
7 GCP 0.77907 0.948718
8 G1R 0.77907 0.961039
9 GSP 0.770115 0.925
10 5GP 0.756098 0.960526
11 G 0.756098 0.960526
12 G2R 0.747253 0.936709
13 GMV 0.747126 0.948718
14 GAV 0.714286 0.936709
15 GP2 0.712644 0.936709
16 G2P 0.711111 0.936709
17 Y9Z 0.708333 0.880952
18 GDD 0.690722 0.936709
19 GKE 0.690722 0.936709
20 GDC 0.690722 0.936709
21 G5P 0.686869 0.948718
22 GPG 0.684211 0.936709
23 GFB 0.683673 0.936709
24 GDR 0.683673 0.936709
25 GTG 0.683673 0.91358
26 GDP BEF 0.681319 0.911392
27 GKD 0.68 0.936709
28 JB2 0.68 0.936709
29 6CK 0.676768 0.91358
30 G3A 0.676768 0.948718
31 GTP MG 0.673913 0.935065
32 GDX 0.673267 0.948718
33 ALF 5GP 0.67033 0.86747
34 YGP 0.663265 0.879518
35 GPD 0.656863 0.902439
36 GDP AF3 0.645833 0.86747
37 GDP ALF 0.645833 0.86747
38 JB3 0.641509 0.925
39 DBG 0.640351 0.974359
40 G3D 0.638298 0.960526
41 G4P 0.625 0.960526
42 GMP 0.621951 0.857143
43 NGD 0.62037 0.936709
44 GGM 0.618182 0.925926
45 0O2 0.616162 0.960526
46 KB7 0.612903 0.807229
47 2MD 0.603604 0.870588
48 CAG 0.60177 0.904762
49 FEG 0.590909 0.858824
50 U2G 0.590909 0.91358
51 GDP 7MG 0.590476 0.888889
52 MGD 0.587719 0.870588
53 ZGP 0.585586 0.848837
54 CG2 0.580357 0.91358
55 KBD 0.568627 0.807229
56 ANP 0.568421 0.922078
57 PGD 0.567797 0.902439
58 MD1 0.567797 0.870588
59 3GP 0.56044 0.922078
60 TPG 0.558333 0.822222
61 GH3 0.55 0.948052
62 KBJ 0.54717 0.77907
63 FE9 0.546219 0.778947
64 GPX 0.539216 0.922078
65 G4M 0.539062 0.860465
66 DGI 0.536082 0.9
67 BGO 0.535088 0.901235
68 IDP 0.53125 0.947368
69 DGT 0.53 0.9
70 2GP 0.526882 0.935065
71 G1R G1R 0.520325 0.901235
72 QBQ 0.515152 0.960526
73 I2C FE2 CMO CMO 0.508197 0.811111
74 AGO 0.504202 0.91358
75 P2G 0.5 0.860759
76 G1G 0.5 0.902439
77 MGP 0.49505 0.936709
78 R5I 0.49505 0.922078
79 R7I 0.49505 0.922078
80 PGD O 0.492063 0.831461
81 6G0 0.490196 0.936709
82 P1G 0.489796 0.85
83 AKW 0.483051 0.869048
84 DG 0.474227 0.8875
85 DGP 0.474227 0.8875
86 IMP 0.463918 0.934211
87 G2Q 0.462963 0.936709
88 CZF 0.460784 0.909091
89 GPC 0.459677 0.858824
90 G C 0.459016 0.878049
91 GTA 0.448276 0.91358
92 G7M 0.444444 0.924051
93 MAP 0.439252 0.898734
94 B4P 0.434343 0.871795
95 ADP 0.434343 0.896104
96 AP5 0.434343 0.871795
97 A2D 0.43299 0.871795
98 AT4 0.43 0.8625
99 SGP 0.425743 0.807229
100 AU1 0.425743 0.922078
101 BA3 0.424242 0.871795
102 APC G U 0.423077 0.864198
103 C2E 0.423077 0.897436
104 35G 0.423077 0.909091
105 PCG 0.423077 0.909091
106 HEJ 0.421569 0.896104
107 ATP 0.421569 0.896104
108 ACQ 0.419048 0.873418
109 5GP 5GP 0.419048 0.860759
110 AQP 0.417476 0.896104
111 5FA 0.417476 0.896104
112 01G 0.417391 0.880952
113 UNP 0.415842 0.810127
114 AN2 0.415842 0.909091
115 6AD 0.415094 0.821429
116 M33 0.411765 0.860759
117 ITT 0.411765 0.846154
118 JSQ 0.409524 0.851852
119 HFD 0.409524 0.851852
120 ACP 0.407767 0.873418
121 KG4 0.407767 0.873418
122 6YZ 0.407407 0.873418
123 AR6 0.403846 0.871795
124 APR 0.403846 0.871795
125 A4P 0.403226 0.848837
126 UCG 0.402985 0.888889
127 M7G A2M G 0.4 0.791209
128 AD9 0.4 0.873418
129 AGS 0.4 0.851852
Ligand no: 2; Ligand: 14J; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 14J 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: GNP; Similar ligands found: 41
No: Ligand Similarity coefficient
1 BEF GDP 0.9966
2 ALF GDP 0.9853
3 BEF ADP 0.9788
4 DTP 0.9719
5 ADP BEF 0.9564
6 ADP ALF 0.9518
7 GDP MG 0.9489
8 ADP AF3 0.9407
9 UTP 0.9203
10 ADP MG 0.9170
11 CTP 0.9164
12 ATF 0.9160
13 MGT 0.9145
14 P5A 0.9069
15 APC 0.8983
16 AMO 0.8940
17 DSZ 0.8934
18 SSA 0.8828
19 TSB 0.8826
20 A12 0.8814
21 ATP MG 0.8808
22 8X1 0.8806
23 PR8 0.8796
24 DAT 0.8750
25 5AL 0.8746
26 MGO 0.8726
27 NSS 0.8721
28 G5A 0.8710
29 3AT 0.8675
30 SRP 0.8665
31 SAM 0.8658
32 TAT 0.8655
33 A5A 0.8651
34 4AD 0.8639
35 KAA 0.8631
36 8DG 0.8607
37 VO4 ADP 0.8602
38 GCP G 0.8590
39 ADX 0.8588
40 ANP MG 0.8566
41 TTP 0.8526
Ligand no: 2; Ligand: 14J; Similar ligands found: 986
No: Ligand Similarity coefficient
1 FQI 0.9964
2 BEN 0.9705
3 NIO 0.9681
4 NCA 0.9676
5 PKU 0.9674
6 BAM 0.9666
7 7WG 0.9662
8 BEZ 0.9661
9 8GC 0.9656
10 UNU 0.9639
11 PRO 0.9633
12 PCA 0.9630
13 AC0 0.9626
14 OAA 0.9626
15 FOA 0.9612
16 PYC 0.9610
17 NMJ 0.9609
18 WCE 0.9598
19 11S 0.9594
20 4CS 0.9594
21 FK1 0.9590
22 H4N 0.9589
23 PBC 0.9587
24 MLT 0.9582
25 OHG 0.9580
26 8NY 0.9579
27 PZA 0.9573
28 3AB 0.9572
29 VGL 0.9571
30 3HB 0.9568
31 6PC 0.9567
32 TP5 0.9566
33 GAB 0.9566
34 TZC 0.9562
35 JBN 0.9558
36 OVV 0.9553
37 QSC 0.9551
38 JAE 0.9551
39 NTN 0.9547
40 NBZ 0.9545
41 53C 0.9544
42 YCP 0.9541
43 ES9 0.9539
44 1DV 0.9539
45 FBJ 0.9535
46 BE7 0.9533
47 5MB 0.9532
48 2PC 0.9531
49 6AI 0.9529
50 BRT 0.9527
51 5MI 0.9526
52 XBT 0.9525
53 3NT 0.9524
54 SMV 0.9521
55 BNS 0.9512
56 DPR 0.9511
57 F60 0.9511
58 3BZ 0.9503
59 NPO 0.9502
60 265 0.9499
61 Z82 0.9499
62 M58 0.9497
63 14O 0.9493
64 5H1 0.9492
65 5HN 0.9483
66 2K4 0.9479
67 C21 0.9479
68 PHB 0.9478
69 54D 0.9476
70 IT2 0.9471
71 BZX 0.9464
72 JAB 0.9461
73 PRS 0.9450
74 UY7 0.9449
75 PAB 0.9449
76 2RH 0.9442
77 174 0.9441
78 MR1 0.9438
79 PBZ 0.9436
80 AC6 0.9426
81 BP9 0.9426
82 HBD 0.9426
83 P72 0.9425
84 SS1 0.9419
85 NIZ 0.9417
86 HYP 0.9416
87 60P 0.9415
88 3OC 0.9411
89 1P3 0.9411
90 UGC 0.9404
91 1Y6 0.9403
92 TH7 0.9397
93 BHO 0.9390
94 DYA 0.9389
95 1P7 0.9377
96 273 0.9376
97 ZBT 0.9367
98 1DU 0.9363
99 GAG 0.9362
100 BZ3 0.9360
101 RSF 0.9357
102 1SA 0.9357
103 717 0.9355
104 5AC 0.9354
105 F9Y 0.9354
106 8K2 0.9350
107 4MA 0.9349
108 HX2 0.9348
109 OXQ 0.9347
110 282 0.9344
111 TZL 0.9336
112 826 0.9336
113 RM1 0.9336
114 5XC 0.9332
115 SW7 0.9332
116 F9P 0.9331
117 5OB 0.9331
118 5B1 0.9330
119 OVM 0.9329
120 GBD 0.9329
121 H42 0.9329
122 COI 0.9326
123 ISZ 0.9326
124 HY3 0.9325
125 3MB 0.9320
126 HY1 0.9316
127 3DO 0.9313
128 TFB 0.9312
129 6M9 0.9308
130 0RW 0.9301
131 LDU 0.9300
132 4FS 0.9299
133 RSO 0.9299
134 OVP 0.9296
135 LMR 0.9294
136 AMC 0.9293
137 2AQ 0.9292
138 JB5 0.9292
139 5JC 0.9283
140 I3A 0.9283
141 TH0 0.9283
142 JZ5 0.9283
143 HBA 0.9283
144 AHR 0.9283
145 SRT 0.9282
146 HIO 0.9282
147 ASP 0.9281
148 JZ9 0.9281
149 RHU 0.9281
150 FBM 0.9280
151 HCS 0.9278
152 HMH 0.9277
153 CFI 0.9276
154 QWN 0.9273
155 2MI 0.9272
156 1DW 0.9271
157 HSE 0.9271
158 DTL 0.9270
159 6M4 0.9265
160 1P8 0.9264
161 IDM 0.9263
162 DEN 0.9263
163 SIN 0.9262
164 FUM 0.9260
165 R8S 0.9259
166 03V 0.9258
167 QXW 0.9257
168 ES5 0.9256
169 SYN 0.9256
170 E5X 0.9253
171 ABN 0.9251
172 MRZ 0.9251
173 IXW 0.9250
174 BZF 0.9249
175 1PT 0.9246
176 OW4 0.9246
177 VGD 0.9244
178 COU 0.9243
179 IND 0.9242
180 BZI 0.9240
181 XYL 0.9239
182 RB5 0.9239
183 CLW 0.9239
184 LZ1 0.9239
185 3U4 0.9238
186 270 0.9238
187 AX7 0.9238
188 GLY GLY 0.9234
189 I1E 0.9234
190 TIU 0.9234
191 PNZ 0.9232
192 HBX 0.9230
193 9YL 0.9229
194 7HQ 0.9229
195 BVC 0.9228
196 36R 0.9227
197 1WD 0.9223
198 7MU 0.9222
199 4JP 0.9222
200 DMD 0.9222
201 ES2 0.9222
202 OCH 0.9222
203 KOJ 0.9222
204 OK7 0.9220
205 FBA 0.9219
206 4SV 0.9217
207 5WV 0.9217
208 4JU 0.9216
209 1DQ 0.9212
210 ABV 0.9212
211 ANN 0.9210
212 XIY 0.9210
213 PYF 0.9209
214 IUR 0.9209
215 51R 0.9209
216 4P5 0.9209
217 9EW 0.9208
218 FAN 0.9208
219 5VM 0.9208
220 MPI 0.9208
221 3F0 0.9207
222 4BZ 0.9207
223 MZG 0.9206
224 XQ0 0.9205
225 2BG 0.9204
226 PY7 0.9203
227 J1Z 0.9201
228 DE5 0.9199
229 47J 0.9197
230 IDH 0.9196
231 5UC 0.9195
232 SAL 0.9195
233 BE2 0.9194
234 4HO 0.9194
235 HSM 0.9194
236 MCT 0.9193
237 F05 0.9193
238 GVH 0.9192
239 4SD 0.9192
240 0CT 0.9191
241 MWJ 0.9191
242 THE 0.9191
243 SNE 0.9190
244 GYE 0.9190
245 0R1 0.9189
246 XUL 0.9189
247 GOJ 0.9188
248 5CU 0.9188
249 HHA 0.9187
250 MRY 0.9186
251 259 0.9186
252 3ID 0.9186
253 4JL 0.9185
254 3M0 0.9185
255 DBH 0.9185
256 4VP 0.9184
257 GLU 0.9184
258 MXN 0.9182
259 JA8 0.9179
260 VNJ 0.9176
261 ET2 0.9174
262 K2T 0.9174
263 ES6 0.9173
264 DOB 0.9171
265 4M0 0.9167
266 2CK 0.9166
267 8H8 0.9166
268 ASN 0.9164
269 4JT 0.9157
270 1MR 0.9156
271 MLA 0.9155
272 4NM 0.9154
273 C2A 0.9152
274 QUZ 0.9152
275 7W4 0.9151
276 8ZE 0.9151
277 NBE 0.9151
278 1MC 0.9151
279 TEO 0.9150
280 69O 0.9149
281 AHB 0.9148
282 5MH 0.9148
283 9CL 0.9145
284 ASO 0.9145
285 BHA 0.9145
286 JZ2 0.9143
287 AMH 0.9143
288 9X7 0.9140
289 FA0 0.9140
290 R2B 0.9139
291 JBK 0.9139
292 XBZ 0.9139
293 TDR 0.9138
294 XCZ 0.9137
295 FPI 0.9137
296 1M2 0.9136
297 MZ0 0.9135
298 J9T 0.9134
299 JKE 0.9134
300 FB2 0.9134
301 TSU 0.9134
302 2YU 0.9134
303 42A 0.9132
304 3HA 0.9130
305 27Y 0.9130
306 URF 0.9128
307 23W 0.9126
308 CYS 0.9125
309 4JM 0.9124
310 HMU 0.9124
311 4CL 0.9122
312 RIB 0.9120
313 7WV 0.9120
314 PZI 0.9120
315 5NU 0.9120
316 2CQ 0.9119
317 4WL 0.9119
318 BCP 0.9118
319 FBB 0.9118
320 PHU 0.9118
321 GUA 0.9118
322 P9P 0.9117
323 DTU 0.9117
324 MWM 0.9116
325 4XR 0.9116
326 TPA 0.9115
327 45L 0.9114
328 DMG 0.9114
329 2MH 0.9113
330 MAE 0.9112
331 BPN 0.9112
332 GTQ 0.9112
333 AL0 0.9112
334 ILE 0.9111
335 XRG 0.9110
336 FPY 0.9110
337 RCO 0.9109
338 43M 0.9107
339 CRS 0.9107
340 4ZE 0.9107
341 WBU 0.9106
342 4JJ 0.9105
343 7N0 0.9105
344 3SL 0.9105
345 FYU 0.9103
346 1WG 0.9102
347 FCR 0.9101
348 MLI 0.9099
349 SVN 0.9099
350 RBL 0.9097
351 24B 0.9097
352 URP 0.9097
353 KKN 0.9096
354 LG4 0.9096
355 BOA 0.9095
356 AKG 0.9094
357 BVG 0.9094
358 ISN 0.9092
359 LZM 0.9092
360 2KT 0.9092
361 BR9 0.9089
362 OKG 0.9088
363 0CU 0.9086
364 6AP 0.9086
365 3HM 0.9086
366 ES7 0.9085
367 XAN 0.9082
368 NVI 0.9081
369 Y8I 0.9081
370 H95 0.9080
371 HX3 0.9080
372 069 0.9080
373 YH7 0.9080
374 2DR 0.9079
375 FBW 0.9079
376 HGQ 0.9079
377 MZW 0.9079
378 P2D 0.9078
379 HQE 0.9078
380 2AC 0.9078
381 HSO 0.9078
382 BML 0.9077
383 1XM 0.9077
384 C5J 0.9076
385 HT4 0.9076
386 ZZT 0.9075
387 PEP 0.9075
388 C2B 0.9074
389 150 0.9074
390 PMB 0.9073
391 4JO 0.9072
392 XM0 0.9071
393 NK 0.9071
394 DHB 0.9071
395 NNO 0.9070
396 SX1 0.9070
397 NPY 0.9069
398 F4Z 0.9069
399 4NC 0.9068
400 9DG 0.9067
401 SN4 0.9067
402 54G 0.9067
403 T2C 0.9066
404 PXY 0.9066
405 A1U 0.9065
406 NSP 0.9065
407 JFJ 0.9064
408 GUN 0.9063
409 APY 0.9063
410 PCR 0.9062
411 7B4 0.9061
412 2HQ 0.9061
413 PYD 0.9060
414 ICP 0.9060
415 XX2 0.9060
416 284 0.9060
417 5MK 0.9059
418 275 0.9059
419 4ZA 0.9057
420 6GU 0.9056
421 TC7 0.9055
422 INO 0.9054
423 HLR 0.9054
424 25R 0.9053
425 LER 0.9052
426 25T 0.9051
427 PZM 0.9049
428 M6W 0.9048
429 M2H 0.9048
430 4ZC 0.9048
431 280 0.9047
432 FW5 0.9046
433 4CH 0.9046
434 TM7 0.9045
435 XYD 0.9043
436 3CH 0.9041
437 HEW 0.9041
438 MLM 0.9041
439 FP1 0.9041
440 4A3 0.9041
441 SHA 0.9041
442 5M0 0.9040
443 P92 0.9040
444 A2F 0.9039
445 SJ5 0.9039
446 B24 0.9038
447 F81 0.9038
448 M4T 0.9037
449 AZA 0.9036
450 ADZ 0.9035
451 N2I 0.9034
452 M1A 0.9034
453 AZG 0.9033
454 DA1 0.9031
455 M3T 0.9030
456 QSB 0.9029
457 9TW 0.9029
458 CWM 0.9028
459 93K 0.9028
460 173 0.9028
461 MAK 0.9027
462 3PY 0.9026
463 MYJ 0.9026
464 34A 0.9026
465 PLQ 0.9025
466 DX4 0.9024
467 BVF 0.9024
468 K34 0.9023
469 0R0 0.9023
470 B3R 0.9022
471 4HS 0.9022
472 AAS 0.9022
473 SS2 0.9021
474 FPN 0.9021
475 2MP 0.9020
476 67N 0.9019
477 JBE 0.9019
478 1DH 0.9019
479 2HG 0.9018
480 XLS 0.9017
481 OTR 0.9017
482 5RG 0.9016
483 PEA 0.9016
484 IHB 0.9015
485 ES0 0.9014
486 HH5 0.9014
487 DGJ 0.9013
488 H8N 0.9013
489 2AL 0.9012
490 ITN 0.9012
491 RJY 0.9012
492 4JN 0.9012
493 2HO 0.9012
494 268 0.9011
495 FHB 0.9010
496 OXZ 0.9009
497 DHR 0.9009
498 HDH 0.9007
499 IFM 0.9006
500 SAN 0.9005
501 TLD 0.9005
502 5GU 0.9003
503 IQ0 0.9003
504 HVQ 0.9003
505 CHB 0.9003
506 AAE 0.9000
507 3Z7 0.8999
508 8WO 0.8998
509 45C 0.8998
510 KIV 0.8996
511 IVA 0.8996
512 ASC 0.8995
513 SER 0.8995
514 RNS 0.8994
515 SD4 0.8992
516 IFL 0.8992
517 HIS 0.8990
518 LG5 0.8990
519 2F6 0.8989
520 9TZ 0.8988
521 NF3 0.8988
522 SYV 0.8987
523 4FA 0.8986
524 6CS 0.8985
525 M6N 0.8984
526 CFP 0.8984
527 PAC 0.8984
528 KDV 0.8983
529 AGK 0.8983
530 IHG 0.8982
531 CYT 0.8982
532 Q88 0.8981
533 4H2 0.8981
534 URA 0.8979
535 DAS 0.8979
536 HPA 0.8978
537 GIF 0.8976
538 ORN 0.8975
539 CXF 0.8974
540 QOS 0.8974
541 LG3 0.8973
542 XQG 0.8973
543 TLA 0.8973
544 MET 0.8972
545 FUD 0.8970
546 LT2 0.8968
547 BGC 0.8967
548 IOL 0.8966
549 KJU 0.8964
550 141 0.8964
551 NOJ 0.8962
552 GLC 0.8961
553 4YO 0.8961
554 SPA 0.8957
555 2EC 0.8955
556 0TU 0.8954
557 TSS 0.8952
558 HHQ 0.8952
559 IGA 0.8951
560 2A9 0.8948
561 CSS 0.8947
562 G3P 0.8940
563 GJZ 0.8939
564 QY9 0.8937
565 0HO 0.8936
566 EUG 0.8935
567 KG7 0.8935
568 ABI 0.8934
569 AEF 0.8933
570 4MV 0.8932
571 2EZ 0.8932
572 JLZ 0.8932
573 2CO 0.8931
574 5QY 0.8930
575 WOT 0.8930
576 FBS 0.8929
577 8GF 0.8927
578 JZ3 0.8926
579 MEW 0.8925
580 51F 0.8925
581 IZC 0.8925
582 PBE 0.8924
583 23A 0.8924
584 CIG 0.8924
585 DOR 0.8923
586 PYJ 0.8922
587 24T 0.8921
588 4J8 0.8921
589 LEU 0.8920
590 ORO 0.8920
591 6NA 0.8919
592 G3E 0.8919
593 0JD 0.8919
594 290 0.8918
595 5JQ 0.8916
596 MQN 0.8915
597 HDA 0.8915
598 CEJ 0.8914
599 PIY 0.8914
600 26D 0.8914
601 7CZ 0.8913
602 RMN 0.8911
603 GZ3 0.8908
604 ABU 0.8907
605 XIX 0.8906
606 86J 0.8906
607 6NI 0.8905
608 8WT 0.8905
609 ABA 0.8904
610 XYP 0.8904
611 3PF 0.8903
612 KUF 0.8903
613 DGY 0.8903
614 5XB 0.8902
615 LXC 0.8902
616 HIU 0.8902
617 CWS 0.8901
618 SKA 0.8901
619 NXA 0.8901
620 ABE 0.8901
621 HYN 0.8901
622 3A9 0.8900
623 LEA 0.8899
624 ADE 0.8898
625 4M4 0.8898
626 AW5 0.8898
627 DFU 0.8898
628 LDP 0.8897
629 6NT 0.8896
630 PG0 0.8894
631 M3H 0.8893
632 YRL 0.8893
633 4HM 0.8891
634 V55 0.8891
635 94W 0.8891
636 4JQ 0.8890
637 CWJ 0.8889
638 JB8 0.8888
639 TAR 0.8886
640 1F1 0.8886
641 H3M 0.8886
642 SSN 0.8884
643 TZE 0.8883
644 M5K 0.8883
645 HQJ 0.8883
646 GLL 0.8882
647 0HN 0.8881
648 2ZM 0.8881
649 OGA 0.8881
650 40E 0.8880
651 FBV 0.8877
652 5NI 0.8876
653 3XX 0.8876
654 2HU 0.8875
655 PEQ 0.8874
656 0V5 0.8874
657 286 0.8874
658 CRN 0.8874
659 JDN 0.8873
660 S2G 0.8873
661 1SP 0.8873
662 3DM 0.8870
663 TYL 0.8869
664 4AA 0.8866
665 7W1 0.8865
666 F0J 0.8864
667 3ZQ 0.8864
668 QX2 0.8863
669 NLE 0.8862
670 IFP 0.8862
671 0TR 0.8862
672 J5I 0.8862
673 DSN 0.8859
674 GLN 0.8858
675 3FH 0.8858
676 ODO 0.8857
677 OW7 0.8856
678 ICF 0.8855
679 9DA 0.8853
680 3BU 0.8853
681 7WA 0.8852
682 MPD 0.8852
683 HC4 0.8851
684 3R6 0.8850
685 OXC 0.8849
686 MS9 0.8849
687 KYD 0.8847
688 VAL 0.8846
689 AZF 0.8846
690 PEL 0.8845
691 AZ8 0.8845
692 PXL 0.8842
693 XAZ 0.8841
694 IPB 0.8840
695 D48 0.8839
696 QWW 0.8839
697 6MP 0.8838
698 ACA 0.8838
699 DIE 0.8837
700 H76 0.8837
701 3NY 0.8837
702 2D0 0.8835
703 DAV 0.8834
704 AQO 0.8834
705 PIM 0.8834
706 2LP 0.8833
707 NDH 0.8833
708 FDB 0.8831
709 P4B 0.8831
710 8OZ 0.8829
711 PE0 0.8829
712 1SH 0.8829
713 GZL 0.8828
714 TTL 0.8828
715 FLA 0.8827
716 3Z8 0.8827
717 PGH 0.8827
718 RIP 0.8825
719 DFB 0.8825
720 DS0 0.8824
721 EA1 0.8824
722 PD2 0.8824
723 FUL 0.8824
724 MRW 0.8824
725 261 0.8824
726 CTL 0.8822
727 GAL 0.8821
728 ZZ3 0.8820
729 7HP 0.8819
730 DGN 0.8819
731 DBX 0.8816
732 13P 0.8815
733 E60 0.8814
734 JZ1 0.8814
735 9MG 0.8813
736 1GP 0.8811
737 3SK 0.8811
738 285 0.8808
739 DUC 0.8805
740 K5W 0.8804
741 8S0 0.8804
742 4HC 0.8803
743 MWP 0.8803
744 DHS 0.8801
745 DIN 0.8801
746 G3H 0.8800
747 5RN 0.8799
748 PGA 0.8798
749 PAH 0.8797
750 0P6 0.8796
751 THR 0.8796
752 10L 0.8796
753 L99 0.8796
754 GP9 0.8795
755 HQT 0.8795
756 9R5 0.8793
757 0MK 0.8792
758 4AP 0.8791
759 KMH 0.8790
760 AJ2 0.8789
761 PM6 0.8788
762 9HX 0.8788
763 A2Q 0.8786
764 XYS 0.8785
765 75K 0.8785
766 271 0.8785
767 IPH 0.8785
768 3AP 0.8785
769 0W8 0.8784
770 T6C 0.8783
771 IV2 0.8783
772 G3F 0.8781
773 5SG 0.8781
774 BDP 0.8780
775 3HG 0.8780
776 2AS 0.8779
777 JAW 0.8778
778 1SQ 0.8777
779 9TY 0.8775
780 FB1 0.8775
781 MBN 0.8772
782 SE2 0.8772
783 URC 0.8772
784 V1L 0.8770
785 KT7 0.8769
786 5IQ 0.8769
787 8CM 0.8769
788 HQY 0.8766
789 BTY 0.8765
790 GXE 0.8765
791 CAQ 0.8764
792 ES4 0.8761
793 HVK 0.8761
794 2AP 0.8761
795 BP1 0.8761
796 SOE 0.8760
797 P3K 0.8760
798 HRZ 0.8759
799 D1X 0.8758
800 A7W 0.8758
801 PDC 0.8757
802 GXY 0.8754
803 82I 0.8753
804 DA4 0.8753
805 TGX 0.8753
806 FUC 0.8752
807 4FH 0.8751
808 HPY 0.8751
809 EQT 0.8751
810 24W 0.8751
811 VNL 0.8749
812 BEW 0.8748
813 R8A 0.8748
814 E7Z 0.8748
815 8G0 0.8747
816 PRY 0.8746
817 A29 0.8743
818 1LQ 0.8743
819 I3E 0.8742
820 CIZ 0.8742
821 5Q0 0.8741
822 CMS 0.8741
823 N5J 0.8741
824 BNF 0.8738
825 5JL 0.8736
826 X0V 0.8736
827 CP 0.8735
828 LNO 0.8735
829 GRE 0.8734
830 S0H 0.8734
831 278 0.8731
832 ICO 0.8731
833 7VD 0.8731
834 LGA 0.8730
835 DIU 0.8729
836 CYH 0.8728
837 CXL 0.8728
838 ES1 0.8724
839 CEE 0.8723
840 JND 0.8722
841 B55 0.8719
842 M4S 0.8719
843 6RQ 0.8719
844 F31 0.8718
845 4YS 0.8717
846 1NP 0.8716
847 G6D 0.8716
848 M2K 0.8713
849 40O 0.8713
850 5QX 0.8711
851 EYK 0.8711
852 BTE 0.8710
853 6X8 0.8709
854 15E 0.8708
855 4XH 0.8708
856 DQY 0.8708
857 HH8 0.8706
858 HAI 0.8706
859 6M1 0.8706
860 6F0 0.8704
861 EKZ 0.8703
862 12Q 0.8702
863 DXX 0.8701
864 BUB 0.8700
865 O72 0.8699
866 OXE 0.8698
867 JPZ 0.8697
868 7VS 0.8693
869 TMT 0.8691
870 2ZV 0.8690
871 LPK 0.8689
872 C2U 0.8687
873 X1S 0.8686
874 N8Y 0.8686
875 DHK 0.8685
876 TBP 0.8685
877 2CH 0.8684
878 IWT 0.8683
879 L5V 0.8683
880 S76 0.8681
881 SOR 0.8681
882 SWA 0.8680
883 TMZ 0.8678
884 25W 0.8677
885 TB6 0.8675
886 A09 0.8675
887 4JC 0.8675
888 42J 0.8673
889 3MC 0.8673
890 GCS 0.8671
891 2IM 0.8671
892 8TX 0.8670
893 PYG 0.8670
894 SNO 0.8668
895 GOL 0.8666
896 4Z4 0.8664
897 9PO 0.8662
898 4XX 0.8662
899 A13 0.8661
900 QMP 0.8659
901 OPE 0.8659
902 HTS 0.8659
903 ECE 0.8659
904 KBB 0.8657
905 8CL 0.8653
906 F4E 0.8652
907 1AN 0.8650
908 JBH 0.8649
909 AJV 0.8648
910 6MH 0.8647
911 ARB 0.8647
912 92Z 0.8647
913 PAE 0.8647
914 1LM 0.8646
915 L89 0.8646
916 6TZ 0.8646
917 FP2 0.8643
918 1XN 0.8643
919 DRL 0.8642
920 BZ2 0.8642
921 HHN 0.8642
922 PQK 0.8640
923 6VD 0.8640
924 AG2 0.8639
925 9FE 0.8633
926 MBD 0.8632
927 3CE 0.8631
928 2PG 0.8629
929 2CM 0.8629
930 RNO 0.8627
931 35C 0.8626
932 B53 0.8626
933 93Q 0.8624
934 15N 0.8623
935 9FL 0.8623
936 J6W 0.8621
937 MUA 0.8621
938 8LG 0.8620
939 2AF 0.8620
940 HA5 0.8618
941 2MY 0.8613
942 HJP 0.8612
943 KJH 0.8610
944 SWD 0.8610
945 J9N 0.8610
946 M1Q 0.8610
947 SRO 0.8609
948 KJY 0.8608
949 OTW 0.8607
950 SAR 0.8607
951 B57 0.8606
952 7MH 0.8606
953 CPZ 0.8605
954 938 0.8603
955 32X 0.8602
956 2C9 0.8602
957 ICB 0.8602
958 E1T 0.8601
959 PBA 0.8601
960 A8C 0.8600
961 MSR 0.8600
962 SKM 0.8599
963 QSH 0.8597
964 R9Y 0.8594
965 CHT 0.8590
966 MPV 0.8590
967 4SX 0.8587
968 DBB 0.8582
969 3MH 0.8578
970 DHQ 0.8572
971 TM4 0.8571
972 9CA 0.8570
973 3FA 0.8569
974 7EX 0.8568
975 152 0.8566
976 FOT 0.8562
977 Q6T 0.8559
978 5RO 0.8558
979 JZ0 0.8558
980 DEE 0.8556
981 J9Q 0.8555
982 ODV 0.8550
983 SNU 0.8546
984 BAE 0.8542
985 52C 0.8541
986 PUT 0.8540
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2C78; Ligand: PUL; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2c78.bio1) has 54 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2C78; Ligand: GNP; Similar sites found with APoc: 240
This union binding pocket(no: 2) in the query (biounit: 2c78.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
1 5GOE GDP 1.97531
2 5CK5 GDP 2.21519
3 5CK5 GDP 2.21519
4 6AU6 GDP 2.91777
5 3EC1 GDP 2.98103
6 4M9Q GNP 3.0837
7 4M9Q GNP 3.0837
8 4M9Q GNP 3.0837
9 3N5C GDP 3.08642
10 3N5C GDP 3.08642
11 3GJ3 GDP 3.16742
12 3GJ0 GDP 3.16742
13 1Z06 GNP 3.1746
14 2G77 GDP 3.20988
15 6HDU GTP 3.26087
16 6HDU GTP 3.26087
17 1MR3 G3D 3.31492
18 5M04 GDP 3.33333
19 1TAD GDP 3.39506
20 1TAD ALF 3.39506
21 1Z0A GDP 3.44828
22 1Z0A GDP 3.44828
23 1Z0A GDP 3.44828
24 1Z0A GDP 3.44828
25 1Z0A GDP 3.44828
26 1Z0A GDP 3.44828
27 1Z0A GDP 3.44828
28 1Z0A GDP 3.44828
29 3M1I GTP 3.45679
30 2FFQ GSP 3.50877
31 6A8D GDP 3.64583
32 2XTZ GSP 3.67232
33 2XTZ GSP 3.67232
34 2XTZ GSP 3.67232
35 6HH2 GDP 3.88889
36 6IZW GSP 3.94089
37 2GCO GNP 3.9801
38 2GCO GNP 3.9801
39 6H17 GSP 3.9801
40 3GJ5 GDP 4.0724
41 3GJ8 GDP 4.0724
42 3GJ5 GDP 4.0724
43 3GJ4 GDP 4.0724
44 3GJ4 GDP 4.0724
45 4LC1 GDP 4.1543
46 4LC1 GDP 4.1543
47 3MJH GTP 4.16667
48 3MJH GTP 4.16667
49 1FZQ GDP 4.41989
50 6G14 G4P 4.42177
51 6G14 G4P 4.42177
52 2Y8E GNP 4.46927
53 2Y8E GNP 4.46927
54 4NON GDP 4.61538
55 2X77 GDP 4.7619
56 2X77 GDP 4.7619
57 4D0N GDP 4.86486
58 6BCB GSP 4.86486
59 1RE0 GDP 4.87805
60 6HXU GTP 4.91803
61 4U5X GNP 5.05618
62 3MD0 GDP 5.07042
63 2WIC GNP 5.24345
64 5JCP GDP ALF 5.2506
65 1YZQ GNP 5.29412
66 3W5J GDP 5.39216
67 1O3Y GTP 5.42169
68 2J59 GTP 5.42169
69 2J59 GTP 5.42169
70 2J59 GTP 5.42169
71 2J59 GTP 5.42169
72 2J59 GTP 5.42169
73 2J59 GTP 5.42169
74 1O3Y GTP 5.42169
75 1J2J GTP 5.42169
76 4DKX GDP 5.55556
77 1RYH GNP 5.91133
78 1I4D GDP 6.25
79 6ZAY GDP 6.34921
80 6ZAY GDP 6.34921
81 3SBD GNP 6.41711
82 2BME GNP 6.45161
83 2BME GNP 6.45161
84 2BME GNP 6.45161
85 2BME GNP 6.45161
86 3Q85 GNP 6.50888
87 3Q85 GNP 6.50888
88 6BC0 GSP 6.66667
89 2CJW GDP 6.77083
90 2CJW GDP 6.77083
91 1Z0K GTP 7.24638
92 1Z0K GTP 7.24638
93 2WMO GTP 7.36842
94 4DCT GDP 7.40741
95 4HDO GNP 7.45342
96 2HT6 GDP 7.47126
97 1F6B GDP 7.57576
98 1F6B GDP 7.57576
99 4KVG GTP 7.69231
100 5UWQ GNP 7.69231
101 5UWO GNP 7.69231
102 5UWS GNP 7.69231
103 5O74 GDP 7.77778
104 5O74 GDP 7.77778
105 5O74 GDP 7.77778
106 5O74 GDP 7.77778
107 4HAT GNP 7.85714
108 6X2Y GNP 7.85714
109 6X2U GNP 7.85714
110 1NVV GNP 7.90123
111 6D5E GNP 7.90123
112 6D5J GNP 7.90123
113 6D5G GNP 7.90123
114 6BVJ GNP 7.90123
115 6D5W GNP 7.90123
116 6D5H GNP 7.90123
117 6V9J GNP 7.90123
118 6BVK GNP 7.90123
119 3NKV GNP 8
120 1ZJ6 G3D 8.02139
121 1ZJ6 G3D 8.02139
122 6IF2 GTP 8.06452
123 6IF3 GTP 8.06452
124 1UAD GNP 8.08081
125 1MKY GDP 8.14815
126 3AQ4 GDP 8.15217
127 5WDR GNP 8.18713
128 1YZG GDP 8.37989
129 3WYF GTP 8.40336
130 3WYF GTP 8.40336
131 3T5G GDP 8.55263
132 5BXQ GDP 8.66142
133 5BXQ GDP 8.66142
134 5BXQ GDP 8.66142
135 1NRJ GTP 9.17431
136 2W2X GSP 9.18919
137 2W2X GSP 9.18919
138 5EE5 GTP 9.35672
139 2C5L GTP 9.40171
140 2C5L GTP 9.40171
141 1DS6 GDP 9.44444
142 3RAB GNP 9.46746
143 1YRB GDP 9.54198
144 1YRB GDP 9.54198
145 4GOJ GNP 9.58333
146 4GOJ GNP 9.58333
147 4ZI2 GNP 9.62963
148 4ZI2 GNP 9.62963
149 3TKL GTP 9.69388
150 6SGE GTP 9.70149
151 4YLG GDP 9.82659
152 4BAS GNP 10.0503
153 4BAS GNP 10.0503
154 2RCN GDP 10.0559
155 1YVD GNP 10.0592
156 2FJU GSP 10.1235
157 4D0G GTP 10.1449
158 1ZC3 GNP 10.6195
159 5TB5 GDP 10.8108
160 2EW1 GNP 10.9453
161 2A5J GDP 10.9948
162 2FH5 GTP 11.215
163 2FH5 GTP 11.215
164 2FH5 GTP 11.215
165 6BCA GSP 11.2583
166 6BCA GSP 11.2583
167 3CNL GNP 11.4504
168 3QBT GNP 11.4943
169 3QBT GNP 11.4943
170 4LHW GNP 11.4943
171 3QBT GNP 11.4943
172 3QBT GNP 11.4943
173 1M2O GNP 12.1053
174 1M2O GNP 12.1053
175 1M2O GNP 12.1053
176 5LEF GTP 12.1212
177 3GJ7 GDP 12.2449
178 5DI3 GNP 12.4324
179 5DI3 GNP 12.4324
180 3DOE GTP 12.5
181 1Z08 GNP 12.9412
182 1VG8 GNP 13.0435
183 1VG8 GNP 13.0435
184 2QTV GNP 13.7725
185 1S8F GDP 14.1243
186 1S8F GDP 14.1243
187 1S8F GDP 14.1243
188 4NCN GTP 14.321
189 4NCN GTP 14.321
190 1VG1 GDP 14.5946
191 1VG9 GDP 14.5946
192 5WLB GNP 14.7059
193 5Z2M GTP 14.7727
194 6UKA GNP 14.8148
195 3T12 GDP ALF 15.1515
196 3T1O GDP 15.1515
197 1WDT GTP 15.3086
198 3Q72 GNP 15.6627
199 1TU3 GNP 15.7895
200 1TU3 GNP 15.7895
201 1TU3 GNP 15.7895
202 1TU3 GNP 15.7895
203 1TU3 GNP 15.7895
204 1UPT GTP 16.6667
205 1UPT GTP 16.6667
206 1UPT GTP 16.6667
207 1UPT GTP 16.6667
208 4TMZ GSP 16.8116
209 4TMZ GSP 16.8116
210 6JFK GDP 18.2716
211 3WYG GTP 18.4211
212 5FG3 GDP 19.0123
213 1R4A GNP 19.6078
214 1R4A GNP 19.6078
215 1R4A GNP 19.6078
216 1R4A GNP 19.6078
217 1KSH GDP 19.8925
218 4KAX GTP 20.1183
219 2W83 GTP 20.6061
220 2W83 GTP 20.6061
221 2W83 GTP 20.6061
222 5UPK GNP 20.8333
223 4R98 GNH 21.0332
224 6ZRN GNP 22.0339
225 3PCR GTP 22.2222
226 6ZSJ GNP 22.4359
227 3CH5 GDP 23.0769
228 3PQC GDP 23.5897
229 2A5F GTP 23.8342
230 1CXZ GSP 26.7442
231 2WJG GDP 27.6596
232 2WJG GDP 27.6596
233 4B47 GDP 29.7521
234 4RD0 GDP 32.0988
235 2QN6 GDP 32.3457
236 5H7J GCP 34.321
237 5H7K GDP 35.0126
238 4ZKD GDP 36.5432
239 1KK1 GNP 39.7531
240 5UWU GNP 45
APoc FAQ
Feedback