Receptor
PDB id Resolution Class Description Source Keywords
4J86 1.48 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/YWBP1 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DILYSINE MOTIF ER RETRIEVAL PROTEIN TRANSP
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
THR PHE LYS LYS THR ASN D:1;
C:1;
Valid;
Valid;
none;
none;
submit data
739.872 n/a O=C([...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4J73 1.44 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF BETA'-COP/P25 COMPLEX SACCHAROMYCES CEREVISIAE BETA PROPELLER DILYSINE MOTIF ER RETRIEVAL SIGNAL COATOMERECOGNITION PROTEIN TRANSPORT
Ref.: RULES FOR THE RECOGNITION OF DILYSINE RETRIEVAL MOT COATOMER. EMBO J. V. 32 926 2013
Members (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1579 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
70% Homology Family (10)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1312 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
50% Homology Family (11)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1130 families.
1 4J84 - ALA ARG LYS LEU ASP n/a n/a
2 4J77 - ALA LYS GLU LYS SER ASP n/a n/a
3 4J79 - GLU LYS VAL HIS VAL GLN n/a n/a
4 2YNO - ALA ALA ALA ALA ALA n/a n/a
5 4J73 - PHE GLU ALA LYS LYS LEU VAL n/a n/a
6 4J81 - LYS PRO HIS SER ASP n/a n/a
7 2YNN - CYS THR PHE LYS THR LYS THR ASN n/a n/a
8 4J78 - LYS THR LYS LEU LEU n/a n/a
9 4J82 - LYS SER HIS GLN GLU n/a n/a
10 4J86 - THR PHE LYS LYS THR ASN n/a n/a
11 4J8B - LEU LYS THR LYS LEU LEU n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: THR PHE LYS LYS THR ASN; Similar ligands found: 103
No: Ligand ECFP6 Tc MDL keys Tc
1 THR PHE LYS LYS THR ASN 1 1
2 CYS THR PHE LYS THR LYS THR ASN 0.791209 0.98
3 THR TYR LYS PHE PHE GLU GLN 0.633663 0.851852
4 GLU ASN PRO THR TYR LYS PHE PHE GLU GLN 0.633663 0.851852
5 THR LYS CYS VAL PHE MET 0.6 0.836364
6 TYR GLN GLU SER THR ASP PHE THR PHE LEU 0.561224 0.754717
7 THR LYS ASN TYR LYS GLN PHE SER VAL 0.535088 0.857143
8 SER ILE ILE ASN PHE GLU LYS LEU 0.529915 0.886792
9 THR LYS ASN TYR LYS GLN THR SER VAL 0.525424 0.907407
10 ASP PHE M3L THR ASP 0.523364 0.754098
11 GLU ILE ILE ASN PHE GLU LYS LEU 0.521368 0.865385
12 LYS ALA VAL PHE ASN PHE ALA THR MET 0.516667 0.842105
13 THR ASN GLU PHE TYR ALA 0.514019 0.796296
14 ILE LEU ALA LYS PHE LEU HIS THR LEU 0.512 0.783333
15 GLU ASN GLN LYS GLU TYR PHE PHE 0.509091 0.833333
16 ALA GLU THR PHE 0.505263 0.836735
17 ILE ASN PHE ASP PHE ASN THR ILE 0.504762 0.777778
18 LYS MET ASN THR GLN PHE THR ALA VAL 0.496 0.890909
19 LYS VAL ILE THR PHE ILE ASP LEU 0.491525 0.903846
20 THR LYS THR ALA THR ILE ASN ALA SER 0.490909 0.865385
21 LYS ALA LEU TYR ASN PHE ALA THR MET 0.488372 0.8
22 VAL LYS VAL VAL ALA LYS LYS TYR ARG ASN 0.486957 0.79661
23 THR ASN GLU TYR LYS VAL 0.486239 0.867925
24 LYS ALA VAL TYR ASN PHE ALA THR MET 0.484375 0.8
25 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.484127 0.849057
26 GLU GLN TYR LYS PHE TYR SER VAL 0.483051 0.839286
27 THR PHE ALY SER ILE MET LYS 0.476562 0.807018
28 ALA LYS PHE ARG HIS ASP 0.466667 0.693548
29 LEU LYS THR LYS LEU LEU 0.464646 0.843137
30 SER ILE ILE GLY PHE GLU LYS LEU 0.463415 0.833333
31 SER LEU PHE ASN THR VAL ALA THR LEU 0.462185 0.826923
32 LEU PRO PHE ASP LYS THR THR ILE MET 0.460432 0.716418
33 ILE LYS LEU GLU THR LYS LYS THR LYS LEU 0.46 0.849057
34 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.456 0.872727
35 ALA ILE PHE GLN SER SER MET THR LYS 0.456 0.857143
36 ALA THR ARG ASN PHE SER GLY 0.453782 0.807018
37 LYS ALA THR LYS MLY 0.451613 0.741379
38 PHE LEU ALA TYR LYS 0.451327 0.75
39 GLY ILE LEU GLU PHE VAL PHE THR LEU 0.45 0.814815
40 LEU THR THR LYS LEU THR ASN THR ASN ILE 0.449541 0.849057
41 GLU GLU TYR LEU GLN ALA PHE THR TYR 0.448819 0.75
42 ALA VAL TYR ASN PHE ALA THR MET 0.447154 0.716667
43 ASP PHE GLU GLU ILE 0.446602 0.745098
44 ALA PHE THR SER 0.443299 0.78
45 THR GLU ASN LEU TYR PHE GLN SER GLY THR 0.442748 0.810345
46 ACE ASN TRP GLU THR PHE 0.439024 0.728814
47 GLN VAL ASN PHE LEU GLY LYS 0.439024 0.865385
48 PHE LEU SER TYR LYS 0.438596 0.789474
49 LEU PRO PHE ASP LYS SER THR ILE MET 0.438356 0.705882
50 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.438356 0.758065
51 GLY TYR GLU ASN PRO THR TYR LYS PHE PHE 0.4375 0.738462
52 ASP ASN ARG LEU GLY LEU VAL TYR GLN PHE 0.4375 0.678571
53 GLY ALA GLN THR PHE TYR VAL ASP GLY ALA 0.430894 0.803571
54 FME TYR PHE ILE ASN ILE LEU THR LEU 0.430769 0.721311
55 ILE ARG LYS ILE LEU PHE LEU ASP GLY ILE 0.430657 0.716667
56 LYS THR LYS LEU LEU 0.43 0.843137
57 LEU PRO PHE GLU LYS SER THR VAL MET 0.426573 0.716418
58 LEU ASP GLU GLU THR GLY GLU PHE LEU 0.42623 0.884615
59 THR LYS CYS VAL VAL MET 0.424528 0.781818
60 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.421053 0.741935
61 THR ASN GLU PHE TYR PHE 0.420561 0.722222
62 ALA GLU THR PHE TYR VAL ASP GLY 0.420561 0.672727
63 GLY GLY LYS LYS LYS TYR GLN LEU 0.418803 0.8
64 LYS VAL LEU PHE LEU ASP GLY 0.418803 0.807692
65 SER TRP PHE GLN THR ASP LEU 0.41791 0.721311
66 LYS THR LYS 0.417582 0.857143
67 GLY ARG PHE ALA ALA ALA ILE ALA LYS 0.416 0.724138
68 CYS VAL ASN GLY SER CYS PHE THR VAL 0.416 0.849057
69 PHE LEU SER THR LYS 0.415929 0.865385
70 PHE SER GLN HIS LYS THR SER TPO ILE 0.413793 0.705882
71 GLY GLY LYS LYS LYS TYR LYS LEU 0.410714 0.8
72 VAL ASP SER LYS ASN THR SER SER TRP 0.410448 0.813559
73 LYS ALA VAL TYR ASN LEU ALA THR MET 0.410448 0.827586
74 ACE PHE LYS PHE PSA LEU AAR 0.409449 0.754098
75 ILE LEU ALA LYS PHE LEU HIS GLU LEU 0.409091 0.716667
76 VAL GLN GLN GLU SER SER PHE VAL MET 0.408333 0.785714
77 CYS THR GLU LEU LYS LEU SER ASP TYR 0.407692 0.839286
78 THR ASN GLU PHE ALA PHE 0.407407 0.745098
79 GLY GLN VAL PRO PHE SER LYS GLU GLU CYS 0.407143 0.734375
80 ALA PHE ARG ILE PRO LEU THR ARG 0.407143 0.681159
81 THR ARG ARG GLU THR GLN LEU 0.40708 0.77193
82 LYS LYS SER LYS THR LYS CYS VAL ILE PHE 0.40708 0.792453
83 VAL THR THR ASP ILE GLN VAL LYS VAL 0.40678 0.846154
84 GLY ILE LEU GLY LEU VAL PHE THR LEU 0.406504 0.811321
85 VAL VAL SER HIS PHE ASN ASP 0.406504 0.745763
86 ARG PRO MET THR PHE LYS GLY ALA LEU 0.406452 0.643836
87 CYS VAL PHE MET 0.40566 0.672727
88 GLU THR PHE TYR VAL ASP GLY 0.404959 0.803571
89 ARG ABA GLN ILE PHE ALA ASN ILE 0.404762 0.843137
90 GLY ASP GLU VAL LYS VAL PHE ARG 0.40458 0.754386
91 ILE ASP TRP PHE ASP GLY LYS ASP 0.404412 0.704918
92 LYS TYR LYS 0.40404 0.788462
93 LYS HPE LYS 0.40404 0.795918
94 ALA THR LYS ILE ASP ASN LEU ASP 0.403361 0.849057
95 SER SER ARG LYS GLU TYR TYR ALA 0.403361 0.733333
96 ALA THR VAL ARG THR TYR SER CYS 0.403226 0.737705
97 GLY ALA GLU THR PHE TYR VAL ASP GLY ALA 0.403101 0.789474
98 0Z3 0.401869 0.633333
99 GLU THR VAL ARG PHE GLN SER ASP 0.401515 0.789474
100 PHE PRO THR LYS ASP VAL ALA LEU 0.4 0.774194
101 ASN GLY TYR GLU ASN PRO THR TYR LYS 0.4 0.738462
102 VAL ASN ASP ILE PHE GLU ALA ILE 0.4 0.754717
103 ALA ARG THR M3L GLN THR ALA ALA LYS ALA 0.4 0.681818
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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