Receptor
PDB id Resolution Class Description Source Keywords
4LM2 1.55 Å EC: 3.1.4.17 CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT462 HOMO SAPIENS FRAGMENT SCREENING HYDROLASE HYDROLASE-HYDROLASE INHIBITOR
Ref.: IDENTIFICATION AND OPTIMIZATION OF PDE10A INHIBITOR FRAGMENT-BASED SCREENING BY NANOCALORIMETRY AND X-R CRYSTALLOGRAPHY. J BIOMOL SCREEN V. 19 497 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NI A:901;
A:902;
B:902;
B:901;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
58.693 Ni [Ni+2...
8ZE A:900;
Valid;
none;
Ki = 940 uM
166.174 C9 H10 O3 c1cc2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C2H 2.09 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 6-CHLORO-N-[(2,4-DIMETHYLTHIAZOL-5-YL)M METHYL-2-[3-(2-QUINOLYL)PROPOXY]PYRIMIDIN-4-AMINE HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Members (67)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
70% Homology Family (77)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
68 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
69 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
70 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
71 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
72 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
73 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
74 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
75 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
76 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
77 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
50% Homology Family (230)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 2CHM ic50 = 5.5 nM 3P4 C23 H29 N6 O3 CCc1c2c([n....
2 3TGG - 0H3 C23 H31 N5 O4 CCCOCCN1c2....
3 3HDZ ic50 = 51 nM PD6 C18 H19 N3 O CCCCN1C=CC....
4 3TGE ic50 = 0.07 nM TGE C24 H32 N6 O4 CCCOCCN1c2....
5 3B2R - VDN C23 H32 N6 O4 S CCCc1nc(c2....
6 2H44 ic50 = 1.7 uM 7CA C27 H32 O10 C[C@H]1[C@....
7 2H42 ic50 = 2.4 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
8 1T9S - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
9 4MD6 ic50 = 17 nM 24E C22 H15 N O3 S c1ccc2c(c1....
10 1UHO Kd ~ 0.6 nM VDN C23 H32 N6 O4 S CCCc1nc(c2....
11 1UDT Kd ~ 0.5 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
12 1RKP - IBM C10 H14 N4 O2 CC(C)CN1c2....
13 4IA0 ic50 = 77 nM 5BB C25 H37 Br N4 O4 S CCCCCCCCC1....
14 3SIE ic50 = 13.3 nM 5BO C20 H27 Br N4 O4 S CCCOc1ccc(....
15 3HC8 ic50 = 2.9 nM PD4 C24 H32 N6 O4 CCCOCCN1c2....
16 1XP0 ic50 = 0.001 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
17 1XOZ ic50 = 0.0012 uM CIA C22 H19 N3 O4 CN1CC(=O)N....
18 6L6E - E6L C23 H26 Cl N7 O3 COc1ccc(cc....
19 4I9Z ic50 = 18.2 nM 5BA C23 H31 Br N4 O3 CCCOc1ccc(....
20 1TBF - VIA C22 H30 N6 O4 S CCCc1c2c(n....
21 4OEX Kd = 0.000000064 M 5EO C20 H28 N4 O4 S CCCOc1ccc(....
22 4G2Y ic50 > 1000 nM NI5 C21 H28 N4 O4 S CCCOc1ccc(....
23 4OEW Kd = 0.000000064 M 5IO C20 H27 I N4 O4 S CCCOc1ccc(....
24 1Y2B ic50 = 82 uM DEE C8 H12 N2 O2 CCOC(=O)c1....
25 6IMD ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
26 1TBB - ROL C16 H21 N O3 COc1ccc(cc....
27 4W1O - 3GJ C19 H17 Cl2 N3 O4 CCc1cc(on1....
28 5LBO - 6M5 C33 H40 N6 O4 COc1ccc(cc....
29 6IMT ic50 = 0.25 uM AK0 C22 H23 F N2 O3 COc1cc2c(c....
30 6RCW - JX2 C30 H33 N3 O4 COc1ccc(cc....
31 6HWO Ki = 0.00000079 M FFZ C28 H29 N3 O3 CC(C)N1C(=....
32 6IMI ic50 = 26.1 uM AH6 C13 H17 N O3 CCOc1cc2c(....
33 6IMB ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
34 1ZKN - IBM C10 H14 N4 O2 CC(C)CN1c2....
35 6NJJ - KR7 C21 H15 Cl F3 N O2 c1cc(cc(c1....
36 3SL4 ic50 = 0.027 uM JN4 C21 H21 N3 O4 S C=CNC(=O)N....
37 1XOQ ic50 = 0.68 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
38 1Y2E ic50 = 0.16 uM 5DE C14 H17 N3 O2 CCOC(=O)c1....
39 1PTW - AMP C10 H14 N5 O7 P c1nc(c2c(n....
40 6FTW - E6Z C25 H29 N3 O3 COc1ccc(cc....
41 5WQA ic50 = 0.011 uM J20 C36 H26 O5 COc1ccc(cc....
42 1Y2D ic50 = 2 uM 4DE C15 H18 N2 O3 CCOC(=O)c1....
43 6F8W ic50 = 23 uM D0E C22 H29 N3 O4 COc1ccc(cc....
44 6AKR - A0O C15 H16 O3 CC(=CCc1c(....
45 1XON ic50 = 0.021 nM PIL C18 H18 Cl2 N2 O3 COc1ccc(cc....
46 6NJH - KRD C19 H18 Cl N5 O CCc1nc(nc(....
47 1TB7 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
48 6FDC ic50 = 2.3 uM DD5 C22 H29 F2 N3 O4 c1cc(c(cc1....
49 6IND ic50 = 0.24 uM AKO C23 H26 N2 O3 Cc1ccc2c(c....
50 6INK ic50 = 0.27 uM AKU C22 H24 N2 O3 COc1cc2c(c....
51 6IMR ic50 = 4.3 uM AJX C23 H26 N2 O3 COc1cc2c(c....
52 1XOR ic50 = 0.39 uM ZAR C12 H10 F2 N2 O3 COc1cc(ccc....
53 3G4K ic50 = 288 nM ROL C16 H21 N O3 COc1ccc(cc....
54 1Y2C ic50 = 0.27 uM 3DE C14 H17 N2 O2 CCOC(=O)c1....
55 2FM0 ic50 = 0.4 nM M98 C23 H18 F8 N2 O4 S c1cc(c[n+]....
56 6KJZ ic50 = 420 nM MKU C24 H26 O6 CC(=CCc1c2....
57 6F8T ic50 = 7 uM CZT C22 H34 N2 O5 C[C@@H]1CN....
58 1Y2K ic50 = 0.021 uM 7DE C14 H15 N3 O4 CCOC(=O)c1....
59 1XOM ic50 = 0.011 uM CIO C20 H25 N O4 COc1ccc(cc....
60 6KK0 ic50 = 17 nM M36 C31 H36 O8 CC(=CCc1c2....
61 2PW3 - CMP C10 H12 N5 O6 P c1nc(c2c(n....
62 6IM6 ic50 = 20.7 uM AH3 C13 H17 N O3 CCOc1cc2c(....
63 1Q9M ic50 = 0.33 uM ROL C16 H21 N O3 COc1ccc(cc....
64 4WCU ic50 = 3 nM 3KQ C24 H22 Cl2 N2 O5 COc1ccc(c(....
65 6F8U ic50 = 0.8 uM CZQ C21 H28 F2 N2 O5 C[C@@H]1CN....
66 6INM ic50 = 0.51 uM AKU C22 H24 N2 O3 COc1cc2c(c....
67 2FM5 ic50 = 43 nM M99 C23 H18 F8 N2 O4 S c1cc(c[n+]....
68 3G4I - D71 C19 H13 N5 O4 c1cc(cc(c1....
69 6F6U ic50 = 16 uM CV8 C21 H30 N2 O5 C[C@@H]1CN....
70 6F8V ic50 = 16 uM D0B C24 H33 N3 O4 C[C@@H]1CN....
71 6IMO ic50 = 0.65 uM AJL C21 H22 N2 O3 COc1cc2c(c....
72 3G4L ic50 = 5.8 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
73 4G2J ic50 = 11 nM 0WF C21 H25 N5 O2 C[C@H](C1=....
74 3K3H - BYE C15 H12 Cl F3 N4 O C[C@@H](CC....
75 3DY8 - IBM C10 H14 N4 O2 CC(C)CN1c2....
76 3DYN - PCG C10 H12 N5 O7 P c1nc2c(n1[....
77 3DYQ - PCG C10 H12 N5 O7 P c1nc2c(n1[....
78 3JSW ic50 = 66 nM JAR C20 H25 N5 O C[C@@H]1C[....
79 3DYS - IBM C10 H14 N4 O2 CC(C)CN1c2....
80 4E90 ic50 = 8 nM 7RG C20 H25 N7 O2 C[C@@H]1C[....
81 5U7K ic50 = 7.1 nM 7Y1 C20 H22 N6 O CCCOc1cncc....
82 6CYD ic50 = 2 nM FKG C16 H15 F3 N4 O2 CC1=Nc2c(c....
83 5TZA ic50 = 0.001 uM 7OG C22 H21 N5 O Cc1cc(n2c(....
84 6C7G ic50 = 18.2 nM EOY C31 H34 Cl N5 O2 Cc1c2nnc(n....
85 5VP0 ic50 = 0.61 nM 9GJ C19 H18 F4 N4 O5 COC[C@H](c....
86 5U00 ic50 = 0.002 uM 7OV C18 H15 F3 I N5 O Cc1cc(n2c(....
87 5U7I ic50 = 66.6 nM 7XS C20 H25 N5 O2 CC(C)Cc1c2....
88 5U7J ic50 = 389.6 nM 7XV C18 H22 N4 O2 CC(C)Cc1nn....
89 5XKM ic50 = 24 nM 87R C18 H17 F3 N4 O2 CC[C@H](c1....
90 6B98 Ki = 22.4 uM D07 C7 H8 Cl N5 CNc1c2cnn(....
91 6B96 Ki = 14.3 nM CZV C15 H11 Cl F3 N5 c1cc(ccc1C....
92 5U7D ic50 = 0.5 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
93 6ZQZ ic50 = 24 nM QOQ C18 H19 Cl F2 N6 Cc1cc(cc(n....
94 5TZX ic50 = 0.052 uM 7OY C18 H15 Cl F3 N5 O Cc1cc(n2c(....
95 6C7I ic50 = 0.38 nM EP7 C22 H22 Cl N5 O2 Cc1c2nnc(n....
96 6CYB ic50 = 0.96 nM FKV C16 H12 F6 N4 O2 C[C@@H](c1....
97 6B97 Ki = 0.237 uM CZY C15 H13 Cl F3 N5 C[C@H](c1c....
98 5TZZ ic50 = 0.014 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
99 5VP1 ic50 = 0.51 nM 9GA C22 H22 F3 N7 O3 Cc1cn2c(c(....
100 4HTX ic50 = 4.7 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
101 6EZF - C6Z C11 H8 Cl2 N2 S c1cc(c(cc1....
102 5TZ3 ic50 = 0.14 uM 7OM C22 H22 N6 O Cc1cc(n2c(....
103 5TZH ic50 = 0.679 uM 7OP C18 H16 F3 N5 O Cc1cc(n2c(....
104 6ZND ic50 = 66 nM QMZ C20 H23 N5 O4 COc1cc(cc(....
105 5TZC ic50 = 0.008 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
106 3ITU ic50 = 40 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
107 6C7F ic50 = 0.00000001 M EOS C22 H22 Cl N5 O2 Cc1c2nnc(n....
108 6C7E ic50 = 0.24 nM EOG C18 H14 Cl N5 O Cc1c2nnc(n....
109 6C7J ic50 = 1.32 nM EPV C25 H28 Cl N5 O2 Cc1c2nnc(n....
110 4JIB ic50 = 45 nM 1L6 C23 H28 N6 O2 CCC(C)(C)c....
111 5U7L ic50 = 4.9 nM 7Y4 C24 H30 N8 CCc1ccc(cc....
112 4D09 ic50 = 1.7 nM 788 C24 H19 N5 O Cc1c2nnc(n....
113 6C7D ic50 = 0.17 nM EOJ C27 H26 Cl N5 O Cc1c2nnc(n....
114 5TZW ic50 = 0.987 uM 7P4 C18 H15 F4 N5 O Cc1cc(n2c(....
115 6CYC ic50 = 14 nM FKJ C15 H13 F3 N4 O3 C[C@@H](c1....
116 4D08 ic50 = 10 nM Q2T C24 H28 N6 O2 CCCCOc1cc(....
117 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
118 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
119 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
120 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
121 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
122 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
123 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
124 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
125 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
126 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
127 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
128 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
129 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
130 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
131 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
132 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
133 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
134 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
135 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
136 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
137 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
138 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
139 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
140 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
141 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
142 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
143 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
144 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
145 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
146 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
147 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
148 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
149 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
150 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
151 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
152 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
153 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
154 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
155 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
156 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
157 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
158 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
159 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
160 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
161 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
162 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
163 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
164 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
165 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
166 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
167 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
168 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
169 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
170 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
171 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
172 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
173 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
174 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
175 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
176 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
177 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
178 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
179 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
180 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
181 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
182 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
183 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
184 5LAQ Ki = 0.63 nM 6M5 C33 H40 N6 O4 COc1ccc(cc....
185 3SHZ ic50 = 35.9 nM 5CO C20 H27 Cl N4 O4 S CCCOc1ccc(....
186 4G2W ic50 = 1.6 nM NI0 C22 H32 N4 O4 S CCCOc1ccc(....
187 3QI4 ic50 = 117.2 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
188 4QGE Ki = 0.5 nM 35O C20 H24 N6 O3 C[C@H](C(=....
189 3QI3 - PDB C15 H12 Cl F3 N4 O C[C@H](CC1....
190 4Y86 ic50 = 58 nM 49E C18 H20 Cl N5 O CC(c1ccc(c....
191 3ECN ic50 = 698 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
192 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
193 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
194 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
195 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
196 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
197 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
198 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
199 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
200 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
201 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
202 2QYK ic50 = 3.3 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
203 3GWT ic50 = 7.94 pM 066 C27 H26 N4 O5 S Cc1cc(cc2c....
204 3WD9 ic50 = 8.3 nM QPC C24 H27 N5 O2 CC(C)(C)CN....
205 4KP6 ic50 = 0.87 nM 1S1 C12 H17 N9 CCC(CC)(C#....
206 4NW7 ic50 = 237 nM 2O5 C20 H17 Cl N4 O2 c1cc(cc(c1....
207 3FRG ic50 = 3.98 nM SK4 C18 H17 N3 O4 S COc1cccc(c....
208 1RO9 - 8BR C10 H13 Br N5 O7 P c1nc(c2c(n....
209 1XOT ic50 = 3.8 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
210 1XLX ic50 = 0.025 uM CIO C20 H25 N O4 COc1ccc(cc....
211 3O57 ic50 = 79.4 pM ZG2 C29 H34 N6 O3 CCn1c2c(cn....
212 3HMV - HBT C17 H17 N3 O4 S C[C@H]1CCc....
213 3O56 ic50 = 794 pM ZG1 C21 H27 N7 O3 CCn1c2c(cn....
214 1XLZ ic50 = 0.96 uM FIL C15 H20 N2 O4 C/C(=NOC(=....
215 1XN0 ic50 = 0.57 uM ROL C16 H21 N O3 COc1ccc(cc....
216 1TB5 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
217 3D3P ic50 = 3.1 nM 20A C21 H25 N5 O2 CCn1c2c(cn....
218 3W5E ic50 = 11 nM NVW C25 H28 N4 O3 S CC(C)(C)NC....
219 4MYQ ic50 = 32 nM 19T C19 H18 Cl N3 O2 S CCc1c(nc(n....
220 2QYL ic50 = 0.65 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
221 1XOS ic50 = 20 uM VIA C22 H30 N6 O4 S CCCc1c2c(n....
222 1XM6 ic50 = 0.42 uM 5RM C14 H19 N O4 CCCOc1cc(c....
223 1RO6 Ki ~ 375 nM ROL C16 H21 N O3 COc1ccc(cc....
224 1Y2H ic50 = 0.056 uM 6DE C14 H15 Cl N2 O2 CCOC(=O)c1....
225 1ROR - AMP C10 H14 N5 O7 P c1nc(c2c(n....
226 5UOY ic50 = 0.027 uM 8HM C24 H27 N5 O3 S COc1ccc(cc....
227 5W6E ic50 = 9.1 nM 0NY C17 H21 N5 O2 Cc1cc([nH]....
228 5B25 Ki = 0.058 nM 4QJ C29 H26 F N7 O CN1C(=O)c2....
229 5UP0 ic50 = 0.46 uM 8HP C18 H15 Cl N4 O S c1cc(ccc1C....
230 3G4G ic50 = 19 nM D71 C19 H13 N5 O4 c1cc(cc(c1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 8ZE; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 8ZE 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: 8ZE; Similar ligands found: 1408
No: Ligand Similarity coefficient
1 N2I 0.9992
2 KDV 0.9907
3 5OB 0.9879
4 BCU 0.9871
5 BZ3 0.9858
6 5XC 0.9853
7 MR1 0.9847
8 2BG 0.9829
9 ES5 0.9805
10 6NT 0.9790
11 JB5 0.9779
12 F9Y 0.9778
13 4FS 0.9771
14 0HN 0.9770
15 SLS 0.9769
16 I3A 0.9769
17 1F1 0.9767
18 0JD 0.9762
19 03V 0.9761
20 2AQ 0.9749
21 XIY 0.9749
22 94W 0.9745
23 CWJ 0.9742
24 OCH 0.9742
25 1M2 0.9738
26 E1T 0.9733
27 3NY 0.9729
28 0HO 0.9726
29 9ZE 0.9724
30 JAW 0.9722
31 N8Y 0.9717
32 COU 0.9716
33 2ZM 0.9715
34 H42 0.9711
35 ESX 0.9706
36 4JQ 0.9704
37 6NI 0.9698
38 15N 0.9693
39 9R5 0.9689
40 ESP 0.9683
41 3A9 0.9664
42 MRW 0.9656
43 BZ2 0.9646
44 J6W 0.9633
45 2HU 0.9625
46 KJU 0.9625
47 K2T 0.9622
48 5NI 0.9619
49 CLW 0.9615
50 JDN 0.9614
51 MQN 0.9611
52 0TU 0.9611
53 R9Y 0.9608
54 ICB 0.9607
55 FBB 0.9606
56 ANN 0.9605
57 JB8 0.9603
58 ES2 0.9601
59 ABI 0.9600
60 0FN 0.9596
61 4YO 0.9592
62 1P8 0.9589
63 PNZ 0.9587
64 6RQ 0.9586
65 36R 0.9585
66 ABV 0.9580
67 11S 0.9579
68 CWS 0.9576
69 NIZ 0.9576
70 9FL 0.9573
71 ET2 0.9568
72 AX7 0.9567
73 1IT 0.9563
74 GJP 0.9562
75 0P6 0.9558
76 9CA 0.9555
77 TSS 0.9555
78 JAE 0.9554
79 6KT 0.9552
80 H4N 0.9548
81 6FZ 0.9547
82 6VD 0.9547
83 4JT 0.9546
84 92P 0.9544
85 FK1 0.9543
86 K97 0.9543
87 X0U 0.9539
88 173 0.9535
89 2EC 0.9534
90 2HQ 0.9533
91 7W1 0.9531
92 ES9 0.9528
93 7HQ 0.9528
94 M4E 0.9527
95 SRO 0.9527
96 C2Y 0.9526
97 4RU 0.9521
98 BHO 0.9520
99 1HN 0.9519
100 5VM 0.9516
101 27B 0.9516
102 4WL 0.9515
103 DIN 0.9514
104 RM1 0.9514
105 ICO 0.9513
106 CFI 0.9512
107 HA5 0.9510
108 5MI 0.9510
109 ISZ 0.9509
110 MEW 0.9508
111 CTL 0.9507
112 BSX 0.9505
113 2LY 0.9504
114 4NM 0.9497
115 2MI 0.9496
116 5GU 0.9496
117 SYV 0.9496
118 KUF 0.9494
119 ESI 0.9494
120 BGC 0.9494
121 IAC 0.9493
122 5WV 0.9492
123 717 0.9492
124 M5K 0.9491
125 BPN 0.9491
126 8NY 0.9489
127 JND 0.9487
128 4HC 0.9487
129 VGD 0.9485
130 Z82 0.9485
131 5RN 0.9484
132 5MB 0.9484
133 4P5 0.9484
134 12Q 0.9482
135 ZYR 0.9481
136 F60 0.9480
137 A7W 0.9480
138 KJH 0.9479
139 0FK 0.9479
140 15E 0.9479
141 J9W 0.9479
142 OVM 0.9478
143 P92 0.9477
144 8XL 0.9474
145 4BL 0.9474
146 14O 0.9473
147 5H1 0.9469
148 8HC 0.9467
149 SKA 0.9463
150 TTL 0.9463
151 TH7 0.9461
152 4FA 0.9461
153 BZX 0.9459
154 8WT 0.9458
155 AN3 0.9457
156 AQO 0.9456
157 OW4 0.9454
158 4BY 0.9453
159 4BZ 0.9453
160 3Z8 0.9451
161 5QY 0.9450
162 AZ8 0.9449
163 2K4 0.9449
164 3MB 0.9449
165 SNO 0.9447
166 8WO 0.9447
167 4HM 0.9446
168 NPO 0.9445
169 MS9 0.9442
170 D48 0.9440
171 DE5 0.9439
172 HMH 0.9438
173 PXL 0.9438
174 TGX 0.9437
175 2HC 0.9436
176 GO2 0.9436
177 9FE 0.9436
178 BZJ 0.9435
179 AMH 0.9433
180 4M0 0.9433
181 3ZB 0.9433
182 I1E 0.9431
183 G3E 0.9430
184 SHA 0.9430
185 PHB 0.9429
186 A7H 0.9428
187 E7S 0.9427
188 5QX 0.9427
189 LDP 0.9427
190 BHA 0.9425
191 TT4 0.9425
192 M2K 0.9424
193 UNJ 0.9424
194 PBA 0.9423
195 5RO 0.9422
196 KOJ 0.9421
197 6AI 0.9421
198 Q24 0.9420
199 M6N 0.9420
200 RNO 0.9419
201 M1Q 0.9419
202 3PF 0.9417
203 174 0.9416
204 JA8 0.9416
205 7W4 0.9416
206 PH2 0.9416
207 J9Q 0.9414
208 DOB 0.9413
209 BK9 0.9413
210 1P7 0.9412
211 12T 0.9410
212 INO 0.9410
213 HQT 0.9409
214 KYA 0.9409
215 SKF 0.9409
216 2FY 0.9408
217 E5X 0.9407
218 270 0.9405
219 APS 0.9405
220 TSR 0.9405
221 5CU 0.9405
222 ES7 0.9404
223 EVF 0.9404
224 XQ0 0.9403
225 YRL 0.9401
226 ISN 0.9399
227 4ZA 0.9398
228 EUG 0.9398
229 5NU 0.9397
230 HDH 0.9397
231 PAB 0.9397
232 J5I 0.9395
233 EYV 0.9395
234 FA0 0.9393
235 86J 0.9393
236 BNF 0.9393
237 7ME 0.9392
238 F4E 0.9392
239 BEA 0.9387
240 PE0 0.9387
241 PEY 0.9385
242 IV2 0.9383
243 XM0 0.9382
244 F31 0.9380
245 NDH 0.9379
246 SE2 0.9378
247 259 0.9376
248 8CM 0.9376
249 5B1 0.9375
250 4MA 0.9375
251 KTW 0.9374
252 AJ2 0.9372
253 4MU 0.9369
254 PBZ 0.9367
255 JG8 0.9364
256 3DM 0.9363
257 4TU 0.9361
258 92K 0.9360
259 SW7 0.9360
260 DNF 0.9360
261 428 0.9360
262 EA1 0.9359
263 GLC 0.9358
264 OW7 0.9356
265 5LA 0.9354
266 MAJ 0.9351
267 FDR 0.9347
268 3R6 0.9346
269 NOJ 0.9346
270 P72 0.9345
271 IWT 0.9344
272 R8S 0.9343
273 4AA 0.9342
274 MSR 0.9342
275 DQU 0.9338
276 PRF 0.9336
277 7VS 0.9336
278 DHB 0.9335
279 TYL 0.9334
280 HHR 0.9334
281 GTQ 0.9333
282 826 0.9330
283 1L5 0.9329
284 OVP 0.9328
285 HBD 0.9326
286 42A 0.9326
287 FUD 0.9325
288 J9N 0.9324
289 URC 0.9324
290 5TY 0.9323
291 PQ0 0.9322
292 ODO 0.9321
293 AJV 0.9319
294 FBM 0.9317
295 MVN 0.9317
296 67N 0.9314
297 HX3 0.9314
298 36E 0.9313
299 0F9 0.9313
300 4NB 0.9312
301 LQ2 0.9312
302 TZF 0.9310
303 B62 0.9309
304 BTY 0.9307
305 8W9 0.9305
306 UAN 0.9304
307 CPZ 0.9303
308 KKN 0.9302
309 LNR 0.9302
310 2O6 0.9301
311 QX4 0.9301
312 1A7 0.9300
313 1Y6 0.9299
314 N1E 0.9297
315 93K 0.9296
316 JLZ 0.9295
317 CH9 0.9295
318 SNU 0.9293
319 44W 0.9293
320 GOJ 0.9293
321 PPY 0.9291
322 XAN 0.9289
323 PJW 0.9288
324 P9P 0.9286
325 DMD 0.9285
326 Q88 0.9285
327 54G 0.9285
328 2HO 0.9284
329 XHP 0.9284
330 J9T 0.9283
331 1DW 0.9282
332 NNO 0.9280
333 V55 0.9280
334 M1E 0.9280
335 3VX 0.9279
336 HBO 0.9279
337 CHB 0.9279
338 AC6 0.9278
339 3ID 0.9277
340 2AK 0.9277
341 C1M 0.9276
342 EN1 0.9274
343 AA 0.9273
344 8TX 0.9272
345 LZM 0.9271
346 QWN 0.9270
347 A29 0.9269
348 2A9 0.9268
349 44V 0.9267
350 V1T 0.9266
351 YH7 0.9261
352 DRG 0.9261
353 MWP 0.9260
354 GNM 0.9258
355 L14 0.9258
356 8H8 0.9258
357 B55 0.9257
358 069 0.9257
359 268 0.9256
360 CWM 0.9255
361 M1A 0.9255
362 HQJ 0.9255
363 68A 0.9254
364 FDB 0.9254
365 4I8 0.9254
366 HX4 0.9254
367 FEH 0.9253
368 B57 0.9251
369 GUN 0.9250
370 OTW 0.9249
371 ANF 0.9249
372 QXW 0.9248
373 2K8 0.9248
374 XAZ 0.9246
375 HHS 0.9246
376 HMU 0.9245
377 6QF 0.9244
378 FHB 0.9243
379 F9P 0.9243
380 6ME 0.9242
381 FYU 0.9242
382 2FQ 0.9241
383 KT7 0.9241
384 JP2 0.9240
385 M0Q 0.9240
386 4NC 0.9239
387 LT2 0.9239
388 ZZT 0.9239
389 XX2 0.9238
390 RJY 0.9237
391 AHR 0.9237
392 8IG 0.9236
393 5JQ 0.9236
394 MYJ 0.9236
395 4A3 0.9235
396 H5B 0.9235
397 HH5 0.9234
398 GCS 0.9234
399 AES 0.9234
400 0BP 0.9232
401 M3H 0.9232
402 M4T 0.9231
403 2LP 0.9231
404 OTR 0.9231
405 N91 0.9230
406 97T 0.9230
407 PHE 0.9229
408 8OZ 0.9228
409 VNL 0.9228
410 327 0.9225
411 61M 0.9225
412 AZ9 0.9224
413 ALE 0.9223
414 XDE 0.9223
415 HQD 0.9223
416 3R4 0.9222
417 EXD 0.9222
418 PHU 0.9222
419 DHR 0.9222
420 9TW 0.9222
421 MPV 0.9222
422 S7G 0.9221
423 ES0 0.9220
424 0FO 0.9219
425 1XM 0.9219
426 THA 0.9219
427 3BU 0.9219
428 42J 0.9218
429 0N7 0.9217
430 A5E 0.9217
431 M45 0.9216
432 75K 0.9216
433 3HM 0.9216
434 261 0.9215
435 3QV 0.9211
436 AOT 0.9211
437 E7Z 0.9211
438 5RG 0.9209
439 S0E 0.9208
440 AEF 0.9208
441 P9E 0.9207
442 JTH 0.9207
443 GVG 0.9207
444 CLZ 0.9206
445 GAB 0.9206
446 M0W 0.9203
447 4ME 0.9203
448 I3E 0.9202
449 S7J 0.9202
450 BOA 0.9201
451 7VP 0.9201
452 82I 0.9200
453 VK3 0.9200
454 7B4 0.9198
455 1KP 0.9196
456 52C 0.9195
457 PD2 0.9195
458 0W1 0.9194
459 DRL 0.9194
460 NYL 0.9193
461 7MU 0.9192
462 RNT 0.9192
463 M4S 0.9191
464 BCP 0.9191
465 EUE 0.9190
466 L99 0.9189
467 DIE 0.9189
468 5M0 0.9189
469 F0J 0.9188
470 IHB 0.9188
471 SN4 0.9186
472 OA3 0.9185
473 DNA 0.9185
474 6AP 0.9183
475 9DG 0.9183
476 UFO 0.9183
477 G3F 0.9182
478 4KL 0.9181
479 OVV 0.9181
480 KBZ 0.9179
481 L5V 0.9179
482 JYB 0.9178
483 DEW 0.9178
484 3NT 0.9178
485 9MG 0.9177
486 A7N 0.9176
487 6GU 0.9176
488 BNL 0.9175
489 GZL 0.9174
490 5WU 0.9174
491 PIM 0.9174
492 NQ 0.9173
493 BQ2 0.9172
494 8NX 0.9171
495 KTJ 0.9170
496 XQG 0.9170
497 NFM 0.9170
498 MD6 0.9169
499 IFL 0.9169
500 0CU 0.9168
501 PDC 0.9168
502 DBX 0.9168
503 2CK 0.9167
504 4LW 0.9167
505 APZ 0.9164
506 2KA 0.9163
507 PZM 0.9163
508 HC4 0.9163
509 F05 0.9163
510 24B 0.9163
511 TTY 0.9162
512 2FX 0.9162
513 N2M 0.9162
514 5VL 0.9162
515 KJY 0.9161
516 CKA 0.9160
517 4XF 0.9160
518 LPK 0.9158
519 YPN 0.9157
520 PRZ 0.9157
521 IOS 0.9156
522 4XR 0.9156
523 NSP 0.9156
524 2D0 0.9155
525 258 0.9155
526 DHY 0.9155
527 ANC 0.9154
528 INE 0.9154
529 5JL 0.9152
530 GAL 0.9152
531 14J 0.9151
532 FP1 0.9150
533 DEE 0.9150
534 R20 0.9150
535 264 0.9148
536 1QP 0.9146
537 0LH 0.9146
538 ZEC 0.9144
539 4VY 0.9143
540 RXA 0.9142
541 L22 0.9142
542 NID 0.9142
543 DHC 0.9140
544 EOL 0.9139
545 MO8 0.9139
546 4Z4 0.9139
547 DX4 0.9138
548 HLZ 0.9138
549 ONR 0.9137
550 6CS 0.9137
551 ASC 0.9136
552 AZA 0.9136
553 JF1 0.9136
554 M1H 0.9136
555 6FB 0.9135
556 DBH 0.9134
557 PQK 0.9133
558 PKU 0.9133
559 VXX 0.9132
560 QBK 0.9132
561 263 0.9132
562 HSO 0.9132
563 PIY 0.9131
564 QIV 0.9130
565 GO8 0.9129
566 5MK 0.9129
567 IPB 0.9128
568 KMY 0.9127
569 NLA 0.9127
570 6M9 0.9125
571 Y3L 0.9125
572 FCR 0.9122
573 SX1 0.9122
574 FK8 0.9121
575 GXY 0.9121
576 3M0 0.9121
577 RNS 0.9120
578 NPY 0.9119
579 45L 0.9119
580 Z5P 0.9119
581 M6Z 0.9118
582 HBA 0.9118
583 X0V 0.9114
584 209 0.9113
585 BIK 0.9110
586 4M4 0.9110
587 HIS 0.9108
588 LR5 0.9106
589 8S0 0.9106
590 4NZ 0.9105
591 DHK 0.9105
592 ST2 0.9104
593 TSU 0.9104
594 2QC 0.9104
595 T9G 0.9104
596 PZI 0.9103
597 BDP 0.9103
598 8NB 0.9102
599 3AE 0.9102
600 FQI 0.9102
601 8G0 0.9101
602 6TZ 0.9100
603 DVQ 0.9099
604 FBF 0.9099
605 4XV 0.9099
606 DGJ 0.9098
607 NAG 0.9097
608 K34 0.9096
609 OAA 0.9095
610 36Y 0.9094
611 SKM 0.9094
612 36M 0.9093
613 B60 0.9093
614 XYL 0.9092
615 H7Y 0.9092
616 RB5 0.9092
617 MAQ 0.9092
618 344 0.9092
619 GDE 0.9091
620 4JC 0.9090
621 PO6 0.9089
622 XCG 0.9089
623 AZG 0.9088
624 R9S 0.9088
625 XDK 0.9087
626 5WZ 0.9086
627 FF2 0.9085
628 4VP 0.9085
629 E35 0.9084
630 QSB 0.9084
631 TPA 0.9084
632 6M4 0.9084
633 QUZ 0.9083
634 PFL 0.9083
635 TAG 0.9082
636 GLO 0.9082
637 23J 0.9082
638 290 0.9081
639 9TZ 0.9081
640 Q02 0.9079
641 GJZ 0.9079
642 TXW 0.9078
643 JF2 0.9078
644 JFJ 0.9077
645 A2F 0.9077
646 FAN 0.9077
647 3J8 0.9074
648 AEH 0.9074
649 GCU 0.9074
650 H8N 0.9073
651 3BZ 0.9072
652 SAF 0.9070
653 DIU 0.9070
654 H33 0.9069
655 QPR 0.9068
656 7B3 0.9067
657 3DO 0.9066
658 RD4 0.9065
659 FHC 0.9065
660 5GT 0.9062
661 TMG 0.9062
662 4XS 0.9062
663 R8V 0.9061
664 363 0.9058
665 HY1 0.9057
666 IGA 0.9057
667 NCT 0.9055
668 1U6 0.9055
669 6LW 0.9054
670 TCA 0.9054
671 C9E 0.9053
672 H4E 0.9053
673 3XX 0.9053
674 LYL 0.9053
675 W81 0.9053
676 3HB 0.9053
677 BE2 0.9053
678 DBJ 0.9052
679 NOY 0.9051
680 B53 0.9050
681 ASO 0.9050
682 TYR 0.9050
683 PRY 0.9050
684 ZON 0.9049
685 HA7 0.9049
686 IF7 0.9048
687 4J8 0.9048
688 SWA 0.9048
689 3IT 0.9048
690 NVU 0.9048
691 MUA 0.9044
692 SAN 0.9044
693 AX3 0.9044
694 ZZZ 0.9043
695 ARP 0.9043
696 0W8 0.9043
697 SAL 0.9043
698 AJY 0.9041
699 3HA 0.9041
700 R2P 0.9040
701 GCB 0.9040
702 AM4 0.9039
703 GF4 0.9039
704 9RW 0.9039
705 O2A 0.9038
706 3F0 0.9038
707 PRA 0.9038
708 YZM 0.9037
709 SMN 0.9036
710 PAC 0.9035
711 SR1 0.9033
712 EVA 0.9033
713 5NE 0.9032
714 Q6T 0.9030
715 SOE 0.9030
716 GCO 0.9028
717 Z13 0.9027
718 CK2 0.9026
719 39O 0.9026
720 7ZE 0.9026
721 1LQ 0.9026
722 HKD 0.9025
723 X0W 0.9024
724 XRG 0.9024
725 QWW 0.9023
726 OMD 0.9022
727 PEL 0.9022
728 BPY 0.9021
729 WOO 0.9021
730 XBT 0.9021
731 4SX 0.9020
732 CFP 0.9019
733 2FG 0.9019
734 7MX 0.9017
735 0XT 0.9017
736 QUS 0.9016
737 LCN 0.9016
738 RMN 0.9015
739 PEA 0.9015
740 53C 0.9015
741 EKZ 0.9014
742 G2F 0.9014
743 LGC 0.9013
744 C2U 0.9013
745 ALL 0.9012
746 CTS 0.9012
747 2H5 0.9012
748 PYQ 0.9011
749 QX2 0.9011
750 DHQ 0.9011
751 KTA 0.9010
752 NMJ 0.9009
753 APG 0.9009
754 JBZ 0.9008
755 4CM 0.9008
756 5WY 0.9007
757 JZ4 0.9007
758 4V2 0.9006
759 LKA 0.9006
760 DX3 0.9005
761 URO 0.9002
762 TOF 0.9001
763 0RW 0.9000
764 ZB1 0.8999
765 NF3 0.8999
766 141 0.8998
767 CXH 0.8998
768 SOR 0.8996
769 OK7 0.8993
770 G5V 0.8993
771 RAT 0.8993
772 42C 0.8992
773 O72 0.8992
774 XIZ 0.8992
775 EGR 0.8992
776 0NX 0.8991
777 M5H 0.8990
778 1Z6 0.8990
779 BPU 0.8989
780 7WR 0.8989
781 PFB 0.8989
782 JBH 0.8988
783 AY4 0.8987
784 2ZQ 0.8987
785 5NS 0.8987
786 535 0.8987
787 24W 0.8986
788 5IQ 0.8985
789 2AL 0.8985
790 IOP 0.8983
791 1NP 0.8983
792 4FH 0.8983
793 3U4 0.8983
794 ES1 0.8982
795 IFP 0.8982
796 795 0.8979
797 TIU 0.8979
798 7NI 0.8979
799 NPA 0.8978
800 4YS 0.8976
801 091 0.8976
802 VOH 0.8976
803 F4K 0.8975
804 FBS 0.8975
805 GLA 0.8975
806 8GC 0.8975
807 SG2 0.8974
808 3WA 0.8974
809 5SG 0.8973
810 HQY 0.8973
811 N4E 0.8973
812 OGA 0.8973
813 1SQ 0.8972
814 SQ7 0.8971
815 1AL 0.8971
816 G4D 0.8971
817 HCI 0.8971
818 HHH 0.8970
819 30G 0.8969
820 QMP 0.8968
821 FE DB1 0.8967
822 AAS 0.8966
823 XYP 0.8966
824 SXS 0.8965
825 CXF 0.8965
826 HDL 0.8964
827 HHI 0.8964
828 DPZ 0.8963
829 7O4 0.8963
830 9EW 0.8963
831 M5E 0.8962
832 SQ4 0.8962
833 ADZ 0.8961
834 3AB 0.8961
835 AKG 0.8960
836 FRU 0.8959
837 1PT 0.8959
838 5Q0 0.8958
839 N5J 0.8958
840 AMS 0.8958
841 JBK 0.8958
842 HHA 0.8957
843 AKH 0.8957
844 OQC 0.8957
845 CSN 0.8955
846 3MG 0.8955
847 FLV 0.8955
848 B56 0.8954
849 ZHA 0.8954
850 57O 0.8952
851 CFA 0.8951
852 5JC 0.8951
853 K4V 0.8951
854 ADA 0.8950
855 ST3 0.8948
856 TWO 0.8948
857 GAF 0.8948
858 149 0.8948
859 MNM 0.8947
860 XX3 0.8946
861 F1A 0.8945
862 NDG 0.8945
863 DFB 0.8945
864 NIO 0.8944
865 BRT 0.8943
866 23A 0.8943
867 SHG 0.8941
868 15L 0.8938
869 2JK 0.8938
870 4CS 0.8937
871 CXP 0.8937
872 D07 0.8936
873 X6X 0.8936
874 46P 0.8935
875 3W8 0.8935
876 DNC 0.8934
877 EV0 0.8933
878 HNT 0.8933
879 ES6 0.8933
880 BGU 0.8932
881 M1Z 0.8931
882 9AP 0.8931
883 M78 0.8930
884 1LM 0.8928
885 P80 0.8926
886 X05 0.8925
887 2F6 0.8924
888 MLT 0.8924
889 S2P 0.8923
890 LDR 0.8923
891 JPZ 0.8923
892 TH0 0.8923
893 DHS 0.8923
894 DA4 0.8923
895 BEN 0.8923
896 BAM 0.8922
897 NDM 0.8921
898 ROI 0.8921
899 2BX 0.8921
900 VNJ 0.8921
901 6N4 0.8920
902 37T 0.8919
903 SVN 0.8919
904 KBG 0.8918
905 9BF 0.8918
906 WCE 0.8918
907 X09 0.8918
908 7MW 0.8917
909 8U3 0.8917
910 51R 0.8917
911 AEG 0.8916
912 5XB 0.8916
913 BMA 0.8915
914 GZ2 0.8914
915 K82 0.8914
916 BEZ 0.8914
917 FIX 0.8913
918 ZBT 0.8913
919 NBZ 0.8913
920 1WC 0.8912
921 1VK 0.8912
922 EMZ 0.8911
923 MXN 0.8910
924 RBL 0.8910
925 9KT 0.8910
926 NCA 0.8910
927 HH8 0.8909
928 3VS 0.8909
929 4XH 0.8909
930 A2G 0.8908
931 LZ2 0.8908
932 2CQ 0.8908
933 GWM 0.8907
934 S60 0.8907
935 HPS 0.8907
936 RHU 0.8907
937 NGT 0.8906
938 SRT 0.8905
939 DK1 0.8905
940 5WX 0.8905
941 3VQ 0.8904
942 20J 0.8904
943 C2B 0.8904
944 8GK 0.8903
945 56D 0.8901
946 2GS 0.8901
947 MQB 0.8901
948 1DJ 0.8900
949 FA1 0.8900
950 IQ5 0.8899
951 XEN 0.8897
952 B5D 0.8896
953 NGO 0.8896
954 MNN 0.8894
955 G12 0.8894
956 KIB 0.8893
957 KIA 0.8893
958 GXL 0.8893
959 HL4 0.8892
960 4JE 0.8892
961 54X 0.8892
962 MZG 0.8891
963 ZXD 0.8891
964 X11 0.8890
965 SSC 0.8885
966 JXN 0.8885
967 JBQ 0.8884
968 ITE 0.8884
969 URS 0.8884
970 MCT 0.8883
971 C53 0.8883
972 FBA 0.8883
973 YTX 0.8883
974 PH3 0.8882
975 QMS 0.8882
976 X48 0.8881
977 PUE 0.8880
978 HRM 0.8880
979 I2E 0.8880
980 N0Z 0.8878
981 Q71 0.8878
982 6PC 0.8878
983 AFR 0.8877
984 SYE 0.8877
985 KP6 0.8876
986 9UL 0.8875
987 P7Y 0.8874
988 JXW 0.8873
989 EYK 0.8872
990 7N0 0.8872
991 D3G 0.8871
992 5HN 0.8871
993 GIV 0.8871
994 NOK 0.8870
995 P3K 0.8869
996 LXC 0.8869
997 27Y 0.8867
998 4SV 0.8867
999 GTR 0.8867
1000 3C4 0.8865
1001 LI6 0.8864
1002 4JM 0.8863
1003 FGZ 0.8863
1004 MWJ 0.8863
1005 4CL 0.8863
1006 4LV 0.8863
1007 E1P 0.8863
1008 CUW 0.8862
1009 PXM 0.8862
1010 UNU 0.8862
1011 GNL 0.8861
1012 NSG 0.8861
1013 BZE 0.8861
1014 GDL 0.8860
1015 3OC 0.8860
1016 F81 0.8859
1017 IJZ 0.8859
1018 OHP 0.8859
1019 K7M 0.8857
1020 AZM 0.8856
1021 N7I 0.8854
1022 7I2 0.8854
1023 4ZC 0.8854
1024 0R0 0.8854
1025 4JJ 0.8851
1026 B85 0.8851
1027 GHM 0.8850
1028 JZ2 0.8850
1029 ZZA 0.8850
1030 K22 0.8847
1031 HNK 0.8847
1032 3FH 0.8847
1033 CEE 0.8847
1034 NGW 0.8846
1035 LVD 0.8846
1036 GVY 0.8846
1037 GYE 0.8846
1038 CIT 0.8845
1039 2CZ 0.8844
1040 PZA 0.8844
1041 MNP 0.8844
1042 B41 0.8843
1043 F2W 0.8842
1044 AAN 0.8842
1045 AMR 0.8841
1046 BA5 0.8840
1047 K3Q 0.8839
1048 Q7A 0.8839
1049 PBC 0.8839
1050 SYA 0.8838
1051 TYE 0.8837
1052 QAT 0.8837
1053 1SS 0.8837
1054 28N 0.8837
1055 BR9 0.8836
1056 UFV 0.8836
1057 3Z7 0.8836
1058 DPT 0.8835
1059 UEG 0.8835
1060 MP5 0.8834
1061 JKE 0.8833
1062 ZME 0.8832
1063 HLR 0.8831
1064 2FT 0.8830
1065 ODK 0.8830
1066 XBZ 0.8829
1067 QY9 0.8828
1068 VGL 0.8828
1069 45C 0.8827
1070 TRP 0.8827
1071 4JL 0.8827
1072 PPT 0.8827
1073 P81 0.8826
1074 XLS 0.8824
1075 BP7 0.8822
1076 5FN 0.8822
1077 86L 0.8822
1078 1DV 0.8822
1079 RUY 0.8821
1080 GC2 0.8821
1081 MB1 0.8820
1082 4HO 0.8819
1083 DDU 0.8819
1084 ZYQ 0.8819
1085 CN0 0.8816
1086 K5W 0.8816
1087 FH2 0.8814
1088 XUL 0.8813
1089 PHH 0.8812
1090 QBM 0.8812
1091 K17 0.8812
1092 FOT 0.8811
1093 S24 0.8810
1094 GZ8 0.8809
1095 5GV 0.8809
1096 E3D 0.8808
1097 XQI 0.8806
1098 6Q3 0.8804
1099 9PY 0.8804
1100 5MH 0.8803
1101 2YU 0.8802
1102