Receptor
PDB id Resolution Class Description Source Keywords
4LM3 1.49 Å EC: 3.1.4.17 CRYSTAL STRUCTURE OF PDE10A2 WITH FRAGMENT ZT464 HOMO SAPIENS FRAGMENT SCREENING HYDROLASE HYDROLASE-HYDROLASE INHIBITOR
Ref.: IDENTIFICATION AND OPTIMIZATION OF PDE10A INHIBITOR FRAGMENT-BASED SCREENING BY NANOCALORIMETRY AND X-R CRYSTALLOGRAPHY. J BIOMOL SCREEN V. 19 497 2014
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NI A:802;
B:802;
A:803;
B:803;
Part of Protein;
Part of Protein;
Part of Protein;
Part of Protein;
none;
none;
none;
none;
submit data
58.693 Ni [Ni+2...
EDO A:804;
B:801;
A:805;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
9ZE A:801;
Valid;
none;
Ki = 1200 uM
178.185 C10 H10 O3 CC(=O...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C2H 2.09 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 6-CHLORO-N-[(2,4-DIMETHYLTHIAZOL-5-YL)M METHYL-2-[3-(2-QUINOLYL)PROPOXY]PYRIMIDIN-4-AMINE HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Members (67)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
70% Homology Family (77)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
68 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
69 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
70 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
71 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
72 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
73 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
74 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
75 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
76 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
77 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
50% Homology Family (230)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 2CHM ic50 = 5.5 nM 3P4 C23 H29 N6 O3 CCc1c2c([n....
2 3TGG - 0H3 C23 H31 N5 O4 CCCOCCN1c2....
3 3HDZ ic50 = 51 nM PD6 C18 H19 N3 O CCCCN1C=CC....
4 3TGE ic50 = 0.07 nM TGE C24 H32 N6 O4 CCCOCCN1c2....
5 3B2R - VDN C23 H32 N6 O4 S CCCc1nc(c2....
6 2H44 ic50 = 1.7 uM 7CA C27 H32 O10 C[C@H]1[C@....
7 2H42 ic50 = 2.4 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
8 1T9S - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
9 4MD6 ic50 = 17 nM 24E C22 H15 N O3 S c1ccc2c(c1....
10 1UHO Kd ~ 0.6 nM VDN C23 H32 N6 O4 S CCCc1nc(c2....
11 1UDT Kd ~ 0.5 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
12 1RKP - IBM C10 H14 N4 O2 CC(C)CN1c2....
13 4IA0 ic50 = 77 nM 5BB C25 H37 Br N4 O4 S CCCCCCCCC1....
14 3SIE ic50 = 13.3 nM 5BO C20 H27 Br N4 O4 S CCCOc1ccc(....
15 3HC8 ic50 = 2.9 nM PD4 C24 H32 N6 O4 CCCOCCN1c2....
16 1XP0 ic50 = 0.001 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
17 1XOZ ic50 = 0.0012 uM CIA C22 H19 N3 O4 CN1CC(=O)N....
18 6L6E - E6L C23 H26 Cl N7 O3 COc1ccc(cc....
19 4I9Z ic50 = 18.2 nM 5BA C23 H31 Br N4 O3 CCCOc1ccc(....
20 1TBF - VIA C22 H30 N6 O4 S CCCc1c2c(n....
21 4OEX Kd = 0.000000064 M 5EO C20 H28 N4 O4 S CCCOc1ccc(....
22 4G2Y ic50 > 1000 nM NI5 C21 H28 N4 O4 S CCCOc1ccc(....
23 4OEW Kd = 0.000000064 M 5IO C20 H27 I N4 O4 S CCCOc1ccc(....
24 1Y2B ic50 = 82 uM DEE C8 H12 N2 O2 CCOC(=O)c1....
25 6IMD ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
26 1TBB - ROL C16 H21 N O3 COc1ccc(cc....
27 4W1O - 3GJ C19 H17 Cl2 N3 O4 CCc1cc(on1....
28 5LBO - 6M5 C33 H40 N6 O4 COc1ccc(cc....
29 6IMT ic50 = 0.25 uM AK0 C22 H23 F N2 O3 COc1cc2c(c....
30 6RCW - JX2 C30 H33 N3 O4 COc1ccc(cc....
31 6HWO Ki = 0.00000079 M FFZ C28 H29 N3 O3 CC(C)N1C(=....
32 6IMI ic50 = 26.1 uM AH6 C13 H17 N O3 CCOc1cc2c(....
33 6IMB ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
34 1ZKN - IBM C10 H14 N4 O2 CC(C)CN1c2....
35 6NJJ - KR7 C21 H15 Cl F3 N O2 c1cc(cc(c1....
36 3SL4 ic50 = 0.027 uM JN4 C21 H21 N3 O4 S C=CNC(=O)N....
37 1XOQ ic50 = 0.68 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
38 1Y2E ic50 = 0.16 uM 5DE C14 H17 N3 O2 CCOC(=O)c1....
39 1PTW - AMP C10 H14 N5 O7 P c1nc(c2c(n....
40 6FTW - E6Z C25 H29 N3 O3 COc1ccc(cc....
41 5WQA ic50 = 0.011 uM J20 C36 H26 O5 COc1ccc(cc....
42 1Y2D ic50 = 2 uM 4DE C15 H18 N2 O3 CCOC(=O)c1....
43 6F8W ic50 = 23 uM D0E C22 H29 N3 O4 COc1ccc(cc....
44 6AKR - A0O C15 H16 O3 CC(=CCc1c(....
45 1XON ic50 = 0.021 nM PIL C18 H18 Cl2 N2 O3 COc1ccc(cc....
46 6NJH - KRD C19 H18 Cl N5 O CCc1nc(nc(....
47 1TB7 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
48 6FDC ic50 = 2.3 uM DD5 C22 H29 F2 N3 O4 c1cc(c(cc1....
49 6IND ic50 = 0.24 uM AKO C23 H26 N2 O3 Cc1ccc2c(c....
50 6INK ic50 = 0.27 uM AKU C22 H24 N2 O3 COc1cc2c(c....
51 6IMR ic50 = 4.3 uM AJX C23 H26 N2 O3 COc1cc2c(c....
52 1XOR ic50 = 0.39 uM ZAR C12 H10 F2 N2 O3 COc1cc(ccc....
53 3G4K ic50 = 288 nM ROL C16 H21 N O3 COc1ccc(cc....
54 1Y2C ic50 = 0.27 uM 3DE C14 H17 N2 O2 CCOC(=O)c1....
55 2FM0 ic50 = 0.4 nM M98 C23 H18 F8 N2 O4 S c1cc(c[n+]....
56 6KJZ ic50 = 420 nM MKU C24 H26 O6 CC(=CCc1c2....
57 6F8T ic50 = 7 uM CZT C22 H34 N2 O5 C[C@@H]1CN....
58 1Y2K ic50 = 0.021 uM 7DE C14 H15 N3 O4 CCOC(=O)c1....
59 1XOM ic50 = 0.011 uM CIO C20 H25 N O4 COc1ccc(cc....
60 6KK0 ic50 = 17 nM M36 C31 H36 O8 CC(=CCc1c2....
61 2PW3 - CMP C10 H12 N5 O6 P c1nc(c2c(n....
62 6IM6 ic50 = 20.7 uM AH3 C13 H17 N O3 CCOc1cc2c(....
63 1Q9M ic50 = 0.33 uM ROL C16 H21 N O3 COc1ccc(cc....
64 4WCU ic50 = 3 nM 3KQ C24 H22 Cl2 N2 O5 COc1ccc(c(....
65 6F8U ic50 = 0.8 uM CZQ C21 H28 F2 N2 O5 C[C@@H]1CN....
66 6INM ic50 = 0.51 uM AKU C22 H24 N2 O3 COc1cc2c(c....
67 2FM5 ic50 = 43 nM M99 C23 H18 F8 N2 O4 S c1cc(c[n+]....
68 3G4I - D71 C19 H13 N5 O4 c1cc(cc(c1....
69 6F6U ic50 = 16 uM CV8 C21 H30 N2 O5 C[C@@H]1CN....
70 6F8V ic50 = 16 uM D0B C24 H33 N3 O4 C[C@@H]1CN....
71 6IMO ic50 = 0.65 uM AJL C21 H22 N2 O3 COc1cc2c(c....
72 3G4L ic50 = 5.8 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
73 4G2J ic50 = 11 nM 0WF C21 H25 N5 O2 C[C@H](C1=....
74 3K3H - BYE C15 H12 Cl F3 N4 O C[C@@H](CC....
75 3DY8 - IBM C10 H14 N4 O2 CC(C)CN1c2....
76 3DYN - PCG C10 H12 N5 O7 P c1nc2c(n1[....
77 3DYQ - PCG C10 H12 N5 O7 P c1nc2c(n1[....
78 3JSW ic50 = 66 nM JAR C20 H25 N5 O C[C@@H]1C[....
79 3DYS - IBM C10 H14 N4 O2 CC(C)CN1c2....
80 4E90 ic50 = 8 nM 7RG C20 H25 N7 O2 C[C@@H]1C[....
81 5U7K ic50 = 7.1 nM 7Y1 C20 H22 N6 O CCCOc1cncc....
82 6CYD ic50 = 2 nM FKG C16 H15 F3 N4 O2 CC1=Nc2c(c....
83 5TZA ic50 = 0.001 uM 7OG C22 H21 N5 O Cc1cc(n2c(....
84 6C7G ic50 = 18.2 nM EOY C31 H34 Cl N5 O2 Cc1c2nnc(n....
85 5VP0 ic50 = 0.61 nM 9GJ C19 H18 F4 N4 O5 COC[C@H](c....
86 5U00 ic50 = 0.002 uM 7OV C18 H15 F3 I N5 O Cc1cc(n2c(....
87 5U7I ic50 = 66.6 nM 7XS C20 H25 N5 O2 CC(C)Cc1c2....
88 5U7J ic50 = 389.6 nM 7XV C18 H22 N4 O2 CC(C)Cc1nn....
89 5XKM ic50 = 24 nM 87R C18 H17 F3 N4 O2 CC[C@H](c1....
90 6B98 Ki = 22.4 uM D07 C7 H8 Cl N5 CNc1c2cnn(....
91 6B96 Ki = 14.3 nM CZV C15 H11 Cl F3 N5 c1cc(ccc1C....
92 5U7D ic50 = 0.5 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
93 6ZQZ ic50 = 24 nM QOQ C18 H19 Cl F2 N6 Cc1cc(cc(n....
94 5TZX ic50 = 0.052 uM 7OY C18 H15 Cl F3 N5 O Cc1cc(n2c(....
95 6C7I ic50 = 0.38 nM EP7 C22 H22 Cl N5 O2 Cc1c2nnc(n....
96 6CYB ic50 = 0.96 nM FKV C16 H12 F6 N4 O2 C[C@@H](c1....
97 6B97 Ki = 0.237 uM CZY C15 H13 Cl F3 N5 C[C@H](c1c....
98 5TZZ ic50 = 0.014 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
99 5VP1 ic50 = 0.51 nM 9GA C22 H22 F3 N7 O3 Cc1cn2c(c(....
100 4HTX ic50 = 4.7 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
101 6EZF - C6Z C11 H8 Cl2 N2 S c1cc(c(cc1....
102 5TZ3 ic50 = 0.14 uM 7OM C22 H22 N6 O Cc1cc(n2c(....
103 5TZH ic50 = 0.679 uM 7OP C18 H16 F3 N5 O Cc1cc(n2c(....
104 6ZND ic50 = 66 nM QMZ C20 H23 N5 O4 COc1cc(cc(....
105 5TZC ic50 = 0.008 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
106 3ITU ic50 = 40 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
107 6C7F ic50 = 0.00000001 M EOS C22 H22 Cl N5 O2 Cc1c2nnc(n....
108 6C7E ic50 = 0.24 nM EOG C18 H14 Cl N5 O Cc1c2nnc(n....
109 6C7J ic50 = 1.32 nM EPV C25 H28 Cl N5 O2 Cc1c2nnc(n....
110 4JIB ic50 = 45 nM 1L6 C23 H28 N6 O2 CCC(C)(C)c....
111 5U7L ic50 = 4.9 nM 7Y4 C24 H30 N8 CCc1ccc(cc....
112 4D09 ic50 = 1.7 nM 788 C24 H19 N5 O Cc1c2nnc(n....
113 6C7D ic50 = 0.17 nM EOJ C27 H26 Cl N5 O Cc1c2nnc(n....
114 5TZW ic50 = 0.987 uM 7P4 C18 H15 F4 N5 O Cc1cc(n2c(....
115 6CYC ic50 = 14 nM FKJ C15 H13 F3 N4 O3 C[C@@H](c1....
116 4D08 ic50 = 10 nM Q2T C24 H28 N6 O2 CCCCOc1cc(....
117 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
118 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
119 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
120 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
121 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
122 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
123 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
124 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
125 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
126 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
127 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
128 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
129 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
130 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
131 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
132 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
133 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
134 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
135 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
136 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
137 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
138 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
139 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
140 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
141 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
142 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
143 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
144 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
145 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
146 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
147 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
148 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
149 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
150 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
151 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
152 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
153 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
154 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
155 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
156 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
157 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
158 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
159 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
160 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
161 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
162 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
163 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
164 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
165 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
166 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
167 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
168 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
169 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
170 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
171 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
172 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
173 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
174 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
175 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
176 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
177 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
178 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
179 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
180 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
181 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
182 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
183 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
184 5LAQ Ki = 0.63 nM 6M5 C33 H40 N6 O4 COc1ccc(cc....
185 3SHZ ic50 = 35.9 nM 5CO C20 H27 Cl N4 O4 S CCCOc1ccc(....
186 4G2W ic50 = 1.6 nM NI0 C22 H32 N4 O4 S CCCOc1ccc(....
187 3QI4 ic50 = 117.2 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
188 4QGE Ki = 0.5 nM 35O C20 H24 N6 O3 C[C@H](C(=....
189 3QI3 - PDB C15 H12 Cl F3 N4 O C[C@H](CC1....
190 4Y86 ic50 = 58 nM 49E C18 H20 Cl N5 O CC(c1ccc(c....
191 3ECN ic50 = 698 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
192 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
193 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
194 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
195 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
196 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
197 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
198 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
199 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
200 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
201 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
202 2QYK ic50 = 3.3 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
203 3GWT ic50 = 7.94 pM 066 C27 H26 N4 O5 S Cc1cc(cc2c....
204 3WD9 ic50 = 8.3 nM QPC C24 H27 N5 O2 CC(C)(C)CN....
205 4KP6 ic50 = 0.87 nM 1S1 C12 H17 N9 CCC(CC)(C#....
206 4NW7 ic50 = 237 nM 2O5 C20 H17 Cl N4 O2 c1cc(cc(c1....
207 3FRG ic50 = 3.98 nM SK4 C18 H17 N3 O4 S COc1cccc(c....
208 1RO9 - 8BR C10 H13 Br N5 O7 P c1nc(c2c(n....
209 1XOT ic50 = 3.8 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
210 1XLX ic50 = 0.025 uM CIO C20 H25 N O4 COc1ccc(cc....
211 3O57 ic50 = 79.4 pM ZG2 C29 H34 N6 O3 CCn1c2c(cn....
212 3HMV - HBT C17 H17 N3 O4 S C[C@H]1CCc....
213 3O56 ic50 = 794 pM ZG1 C21 H27 N7 O3 CCn1c2c(cn....
214 1XLZ ic50 = 0.96 uM FIL C15 H20 N2 O4 C/C(=NOC(=....
215 1XN0 ic50 = 0.57 uM ROL C16 H21 N O3 COc1ccc(cc....
216 1TB5 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
217 3D3P ic50 = 3.1 nM 20A C21 H25 N5 O2 CCn1c2c(cn....
218 3W5E ic50 = 11 nM NVW C25 H28 N4 O3 S CC(C)(C)NC....
219 4MYQ ic50 = 32 nM 19T C19 H18 Cl N3 O2 S CCc1c(nc(n....
220 2QYL ic50 = 0.65 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
221 1XOS ic50 = 20 uM VIA C22 H30 N6 O4 S CCCc1c2c(n....
222 1XM6 ic50 = 0.42 uM 5RM C14 H19 N O4 CCCOc1cc(c....
223 1RO6 Ki ~ 375 nM ROL C16 H21 N O3 COc1ccc(cc....
224 1Y2H ic50 = 0.056 uM 6DE C14 H15 Cl N2 O2 CCOC(=O)c1....
225 1ROR - AMP C10 H14 N5 O7 P c1nc(c2c(n....
226 5UOY ic50 = 0.027 uM 8HM C24 H27 N5 O3 S COc1ccc(cc....
227 5W6E ic50 = 9.1 nM 0NY C17 H21 N5 O2 Cc1cc([nH]....
228 5B25 Ki = 0.058 nM 4QJ C29 H26 F N7 O CN1C(=O)c2....
229 5UP0 ic50 = 0.46 uM 8HP C18 H15 Cl N4 O S c1cc(ccc1C....
230 3G4G ic50 = 19 nM D71 C19 H13 N5 O4 c1cc(cc(c1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 9ZE; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 9ZE 1 1
2 BXS 0.55102 0.714286
3 AJU 0.520833 0.69697
Similar Ligands (3D)
Ligand no: 1; Ligand: 9ZE; Similar ligands found: 1257
No: Ligand Similarity coefficient
1 SLS 0.9871
2 3A9 0.9853
3 JAW 0.9851
4 1F1 0.9846
5 6NT 0.9845
6 15N 0.9844
7 0JD 0.9839
8 0HO 0.9839
9 0HN 0.9838
10 E1T 0.9829
11 6NI 0.9826
12 2ZM 0.9791
13 JB8 0.9790
14 6KT 0.9776
15 ESP 0.9761
16 5NI 0.9759
17 ABI 0.9757
18 GJP 0.9738
19 0FK 0.9732
20 BZJ 0.9731
21 8ZE 0.9724
22 N2I 0.9708
23 3NY 0.9706
24 BZ2 0.9706
25 ESX 0.9699
26 JDN 0.9695
27 N1E 0.9688
28 GO2 0.9673
29 1L5 0.9667
30 27B 0.9651
31 2HU 0.9645
32 ICB 0.9637
33 SKF 0.9629
34 428 0.9626
35 KYA 0.9623
36 1HN 0.9615
37 MR1 0.9615
38 BCU 0.9613
39 K97 0.9610
40 IAC 0.9601
41 8HC 0.9597
42 5OB 0.9592
43 HA5 0.9590
44 9FE 0.9586
45 9FL 0.9585
46 5XC 0.9584
47 KTW 0.9582
48 PPY 0.9570
49 4RU 0.9569
50 6FZ 0.9569
51 2HC 0.9568
52 BZ3 0.9543
53 KDV 0.9534
54 MAJ 0.9531
55 92P 0.9527
56 BQ2 0.9523
57 DNF 0.9521
58 1IT 0.9517
59 6VD 0.9516
60 9CA 0.9513
61 UNJ 0.9509
62 ICO 0.9508
63 4I8 0.9499
64 N8Y 0.9490
65 XIY 0.9489
66 3ZB 0.9488
67 2BG 0.9487
68 4BL 0.9484
69 9R5 0.9484
70 PJW 0.9477
71 4WL 0.9471
72 4BY 0.9470
73 F31 0.9468
74 5RO 0.9467
75 V1T 0.9465
76 J9Q 0.9464
77 EVF 0.9462
78 12T 0.9459
79 S0E 0.9456
80 PEY 0.9454
81 2O6 0.9454
82 AN3 0.9448
83 94W 0.9442
84 ESI 0.9441
85 LQ2 0.9438
86 C2Y 0.9426
87 TSS 0.9426
88 N2M 0.9424
89 3VX 0.9423
90 5TY 0.9422
91 PD2 0.9422
92 R9Y 0.9419
93 INO 0.9419
94 1M2 0.9415
95 PNZ 0.9413
96 YZM 0.9410
97 RNO 0.9410
98 GNM 0.9404
99 J6W 0.9402
100 SNO 0.9398
101 30G 0.9397
102 4P5 0.9397
103 CWJ 0.9396
104 0F9 0.9390
105 CH9 0.9389
106 DNA 0.9388
107 EUE 0.9386
108 M4E 0.9386
109 A7H 0.9385
110 363 0.9385
111 N91 0.9382
112 DHB 0.9381
113 36E 0.9378
114 HHS 0.9377
115 8XL 0.9376
116 M5E 0.9376
117 IOS 0.9376
118 VNL 0.9375
119 AOT 0.9374
120 P9E 0.9373
121 5RN 0.9371
122 93K 0.9368
123 JND 0.9363
124 F9Y 0.9361
125 8W9 0.9360
126 THA 0.9358
127 4LW 0.9358
128 1A7 0.9356
129 8NX 0.9355
130 ZYR 0.9354
131 KJU 0.9353
132 61M 0.9352
133 X0U 0.9352
134 H42 0.9346
135 I3A 0.9345
136 JP2 0.9343
137 4KL 0.9342
138 SRO 0.9342
139 AA 0.9341
140 TYL 0.9341
141 4NB 0.9338
142 PH2 0.9334
143 M5H 0.9334
144 ANN 0.9331
145 0W1 0.9330
146 NAG 0.9330
147 2LY 0.9328
148 ANF 0.9328
149 2FX 0.9327
150 MD6 0.9323
151 5VL 0.9322
152 M78 0.9320
153 M2K 0.9320
154 EXD 0.9318
155 JF1 0.9317
156 NLA 0.9317
157 6QF 0.9316
158 L22 0.9316
159 DRG 0.9315
160 TT4 0.9315
161 KMY 0.9313
162 JG8 0.9312
163 5GT 0.9310
164 L14 0.9309
165 PDC 0.9309
166 4JQ 0.9308
167 MSR 0.9307
168 OW7 0.9305
169 H5B 0.9302
170 LNR 0.9301
171 P9P 0.9301
172 TMG 0.9301
173 F4E 0.9300
174 A29 0.9297
175 EYV 0.9294
176 2K8 0.9291
177 IHB 0.9290
178 E5X 0.9290
179 CHB 0.9288
180 5LA 0.9288
181 03V 0.9287
182 4ZA 0.9285
183 3R4 0.9281
184 4TU 0.9281
185 ANC 0.9279
186 ODO 0.9278
187 9TW 0.9278
188 259 0.9276
189 IWT 0.9276
190 JTH 0.9276
191 2AQ 0.9273
192 TSR 0.9272
193 FF2 0.9270
194 CKA 0.9268
195 8WT 0.9267
196 AHN 0.9265
197 4HM 0.9265
198 NNO 0.9264
199 QSB 0.9264
200 ARP 0.9263
201 BNL 0.9263
202 ONR 0.9262
203 BK9 0.9260
204 BPY 0.9260
205 6FB 0.9255
206 8WO 0.9255
207 XIZ 0.9255
208 ZON 0.9254
209 2HQ 0.9253
210 4NC 0.9252
211 TTY 0.9252
212 S7J 0.9252
213 OCH 0.9250
214 SG2 0.9250
215 BIK 0.9250
216 RD4 0.9247
217 2KA 0.9247
218 VXX 0.9242
219 CSN 0.9239
220 R20 0.9239
221 68A 0.9238
222 XCG 0.9238
223 HQJ 0.9238
224 1VK 0.9237
225 JF2 0.9237
226 36M 0.9236
227 DEW 0.9235
228 4FS 0.9234
229 4A3 0.9233
230 L99 0.9230
231 ES5 0.9229
232 MYJ 0.9229
233 PO6 0.9228
234 HHR 0.9227
235 NFA 0.9225
236 EN1 0.9221
237 JB5 0.9219
238 2HO 0.9218
239 FDR 0.9217
240 4YO 0.9214
241 LDP 0.9211
242 SNU 0.9208
243 AMH 0.9208
244 52C 0.9207
245 7O4 0.9205
246 A5E 0.9204
247 HBO 0.9202
248 HX4 0.9200
249 COU 0.9199
250 FBF 0.9198
251 FHB 0.9193
252 JLZ 0.9193
253 Z5P 0.9190
254 CPZ 0.9190
255 QMS 0.9189
256 3J8 0.9187
257 3HM 0.9187
258 TGX 0.9187
259 DIN 0.9186
260 E7S 0.9185
261 OW4 0.9185
262 5GU 0.9184
263 ZEC 0.9182
264 TCA 0.9181
265 0TU 0.9180
266 MQN 0.9180
267 3R6 0.9179
268 6TZ 0.9179
269 B56 0.9178
270 KUF 0.9177
271 6RQ 0.9177
272 S2P 0.9177
273 5NE 0.9177
274 Y3L 0.9175
275 4NM 0.9174
276 L5V 0.9174
277 MS9 0.9173
278 DNC 0.9173
279 54X 0.9172
280 MRW 0.9169
281 BGC 0.9169
282 ST2 0.9168
283 EUG 0.9168
284 CWS 0.9166
285 NIZ 0.9164
286 XDK 0.9163
287 VGD 0.9163
288 GO8 0.9162
289 EYJ 0.9161
290 A7W 0.9161
291 8G0 0.9161
292 MPV 0.9161
293 15E 0.9159
294 UFO 0.9159
295 2EC 0.9159
296 1P8 0.9158
297 4BZ 0.9158
298 QIV 0.9155
299 XX2 0.9155
300 92K 0.9155
301 FBB 0.9154
302 42A 0.9154
303 X0V 0.9154
304 AJY 0.9152
305 2FY 0.9151
306 0BP 0.9151
307 5QY 0.9151
308 2BX 0.9151
309 PRZ 0.9150
310 717 0.9150
311 4Z4 0.9150
312 M3H 0.9149
313 E7Z 0.9149
314 RM1 0.9148
315 M45 0.9148
316 M6H 0.9147
317 AZM 0.9147
318 36Y 0.9147
319 D48 0.9146
320 8NB 0.9146
321 PFL 0.9145
322 173 0.9144
323 OVM 0.9143
324 P7Y 0.9139
325 4JT 0.9137
326 BPN 0.9137
327 3Z8 0.9137
328 GLC 0.9137
329 K2T 0.9136
330 BEA 0.9134
331 EA1 0.9134
332 IOP 0.9133
333 2JK 0.9133
334 APS 0.9129
335 86J 0.9129
336 J9W 0.9128
337 DHC 0.9128
338 LL1 0.9127
339 7VP 0.9126
340 GDE 0.9126
341 MEW 0.9125
342 C1M 0.9125
343 TXW 0.9125
344 BP7 0.9123
345 4SX 0.9122
346 JRB 0.9119
347 HDH 0.9117
348 GCU 0.9116
349 G3E 0.9115
350 CTL 0.9115
351 3PF 0.9115
352 J5I 0.9114
353 PH3 0.9112
354 0FN 0.9112
355 KOJ 0.9112
356 5WU 0.9111
357 XHP 0.9111
358 97T 0.9110
359 M1Q 0.9108
360 SE2 0.9107
361 ET2 0.9107
362 FUD 0.9106
363 LT2 0.9102
364 9BF 0.9102
365 2FQ 0.9100
366 3MB 0.9100
367 TTL 0.9100
368 HIS 0.9100
369 ST3 0.9099
370 KF5 0.9098
371 ES2 0.9097
372 DHK 0.9096
373 BHA 0.9096
374 7HQ 0.9095
375 I3E 0.9095
376 9UL 0.9094
377 PBA 0.9093
378 SHA 0.9093
379 X48 0.9092
380 344 0.9091
381 PRF 0.9091
382 4XF 0.9090
383 PIM 0.9090
384 7MX 0.9089
385 7W1 0.9088
386 M6N 0.9088
387 R2P 0.9088
388 44V 0.9087
389 AJ2 0.9086
390 GF4 0.9086
391 BDP 0.9086
392 BSX 0.9085
393 CLW 0.9085
394 4HC 0.9084
395 W81 0.9084
396 GZ2 0.9083
397 1P7 0.9083
398 ISZ 0.9083
399 4FH 0.9083
400 DHY 0.9083
401 NPA 0.9082
402 LZM 0.9082
403 0P6 0.9081
404 NDG 0.9080
405 SKA 0.9080
406 NVU 0.9078
407 HKD 0.9078
408 K4V 0.9076
409 4FA 0.9076
410 KJH 0.9075
411 AMR 0.9075
412 FA0 0.9075
413 FQX 0.9074
414 DQU 0.9074
415 LR5 0.9074
416 BNF 0.9074
417 HC4 0.9073
418 4LV 0.9073
419 PHE 0.9072
420 92G 0.9072
421 AEH 0.9072
422 TIH 0.9071
423 CFA 0.9071
424 AQO 0.9071
425 IV2 0.9070
426 ZHA 0.9070
427 3AE 0.9070
428 HNT 0.9070
429 ALE 0.9070
430 4ME 0.9070
431 PE0 0.9069
432 KW8 0.9069
433 1QP 0.9069
434 DOB 0.9069
435 DE5 0.9068
436 QSH 0.9067
437 BZQ 0.9067
438 QX4 0.9066
439 ZYQ 0.9064
440 SYV 0.9063
441 BHO 0.9063
442 2F6 0.9062
443 OTW 0.9061
444 CFI 0.9060
445 M5K 0.9059
446 M6Z 0.9059
447 3QV 0.9058
448 NID 0.9058
449 8CM 0.9057
450 GHM 0.9057
451 B62 0.9056
452 5QX 0.9056
453 6ME 0.9056
454 ATX 0.9055
455 36R 0.9055
456 4AA 0.9054
457 GDL 0.9054
458 NFM 0.9053
459 OA1 0.9051
460 44W 0.9051
461 H4N 0.9050
462 HQD 0.9049
463 OVP 0.9048
464 5GV 0.9048
465 4V2 0.9047
466 HQT 0.9046
467 KTJ 0.9046
468 M4S 0.9045
469 NCT 0.9045
470 8OZ 0.9045
471 0N7 0.9044
472 9AP 0.9044
473 AEF 0.9042
474 N2Z 0.9042
475 AKG 0.9039
476 7MW 0.9038
477 A7N 0.9038
478 NDH 0.9038
479 N0Z 0.9037
480 EOL 0.9037
481 V55 0.9037
482 GZL 0.9037
483 LDR 0.9036
484 12Q 0.9035
485 FK1 0.9035
486 OQC 0.9035
487 2QC 0.9035
488 7WR 0.9035
489 1KP 0.9034
490 5CU 0.9034
491 4M0 0.9033
492 P81 0.9032
493 795 0.9031
494 2GQ 0.9031
495 5NS 0.9031
496 PQK 0.9030
497 4CM 0.9030
498 GWM 0.9028
499 2CZ 0.9028
500 TZF 0.9028
501 EV2 0.9026
502 DRL 0.9025
503 N9J 0.9025
504 PIY 0.9024
505 YTX 0.9024
506 GCS 0.9024
507 SYA 0.9023
508 TZM 0.9023
509 B4O 0.9023
510 HCI 0.9022
511 GVG 0.9022
512 SKM 0.9021
513 5VM 0.9020
514 4NZ 0.9020
515 AM4 0.9019
516 CXH 0.9018
517 TWO 0.9018
518 AZ8 0.9018
519 DPT 0.9016
520 PQ0 0.9015
521 5XB 0.9015
522 SSC 0.9014
523 7VS 0.9011
524 PUE 0.9007
525 28N 0.9007
526 CK1 0.9006
527 FCD 0.9004
528 4XS 0.9003
529 GOJ 0.9001
530 XDE 0.9000
531 G3F 0.9000
532 DHR 0.8999
533 I1E 0.8998
534 ABV 0.8998
535 J9N 0.8998
536 C82 0.8997
537 MB1 0.8997
538 YRL 0.8997
539 OTR 0.8997
540 QPR 0.8995
541 Q02 0.8995
542 VM1 0.8995
543 ZZA 0.8994
544 8NY 0.8993
545 EKZ 0.8993
546 3VQ 0.8991
547 069 0.8991
548 HFA 0.8990
549 H4B 0.8990
550 0LH 0.8989
551 URC 0.8989
552 ZZZ 0.8988
553 3DM 0.8988
554 6ZW 0.8987
555 XAZ 0.8987
556 ZME 0.8986
557 PHB 0.8986
558 UAN 0.8985
559 JA8 0.8985
560 INE 0.8985
561 J9T 0.8984
562 3VW 0.8983
563 E1P 0.8982
564 LZ2 0.8982
565 IL5 0.8982
566 6DP 0.8981
567 7ME 0.8980
568 AY4 0.8980
569 AX3 0.8980
570 4JC 0.8979
571 7AP 0.8978
572 OGA 0.8978
573 N4E 0.8977
574 D3G 0.8977
575 BZX 0.8977
576 Z13 0.8976
577 MQB 0.8976
578 4AB 0.8975
579 11S 0.8975
580 AZ9 0.8975
581 HBI 0.8974
582 1WC 0.8974
583 5NU 0.8972
584 GAL 0.8972
585 ODK 0.8971
586 4XV 0.8971
587 0FO 0.8970
588 C53 0.8970
589 CK2 0.8968
590 M0Q 0.8968
591 MVN 0.8967
592 LVD 0.8967
593 LEL 0.8966
594 N7I 0.8964
595 DEE 0.8964
596 G14 0.8964
597 4NP 0.8963
598 505 0.8963
599 FA1 0.8963
600 BIO 0.8961
601 56D 0.8960
602 0XT 0.8960
603 XX3 0.8958
604 7I2 0.8958
605 FHC 0.8957
606 3W8 0.8956
607 0OL 0.8955
608 JZA 0.8954
609 091 0.8954
610 7FU 0.8953
611 ES9 0.8953
612 TRP 0.8953
613 39O 0.8952
614 GTR 0.8952
615 MO8 0.8951
616 QBM 0.8951
617 AJV 0.8950
618 PBZ 0.8950
619 FGZ 0.8949
620 0NX 0.8949
621 4NS 0.8948
622 5B1 0.8947
623 3VS 0.8947
624 PRO GLY 0.8946
625 JAE 0.8946
626 NPO 0.8946
627 OA3 0.8945
628 AX7 0.8944
629 HJ7 0.8943
630 22L 0.8943
631 1FE 0.8942
632 7W4 0.8942
633 TYR 0.8942
634 PAB 0.8941
635 HHI 0.8939
636 CLZ 0.8939
637 X11 0.8938
638 5JQ 0.8938
639 PHU 0.8937
640 268 0.8937
641 NOJ 0.8937
642 AC6 0.8937
643 5WY 0.8936
644 23J 0.8936
645 DK1 0.8935
646 SQ4 0.8934
647 5WV 0.8934
648 H2B 0.8932
649 3TC 0.8932
650 F4K 0.8932
651 SN4 0.8931
652 DDU 0.8931
653 XQ0 0.8931
654 6Q3 0.8931
655 PLP 0.8931
656 2HG 0.8931
657 S60 0.8929
658 4MU 0.8929
659 H7Y 0.8927
660 42J 0.8927
661 H4E 0.8927
662 EYY 0.8926
663 M1H 0.8926
664 5OF 0.8924
665 I2E 0.8923
666 8MO 0.8923
667 4VY 0.8922
668 FK8 0.8922
669 PMP 0.8922
670 S7A 0.8921
671 BGU 0.8921
672 1Z6 0.8921
673 8U3 0.8919
674 TCR 0.8919
675 ITE 0.8918
676 EVA 0.8917
677 2A9 0.8916
678 8TX 0.8916
679 HBD 0.8916
680 5F5 0.8915
681 ADA 0.8915
682 5OO 0.8915
683 75K 0.8914
684 TH7 0.8914
685 HSO 0.8914
686 MXD 0.8912
687 BTY 0.8911
688 R8S 0.8911
689 7MU 0.8911
690 M1E 0.8911
691 IPB 0.8910
692 AEG 0.8909
693 S2G 0.8909
694 SYE 0.8908
695 EGR 0.8908
696 9NB 0.8906
697 IQ5 0.8904
698 8S0 0.8904
699 M4T 0.8902
700 CN0 0.8900
701 CXP 0.8899
702 KT7 0.8898
703 KTA 0.8898
704 BHQ 0.8897
705 GCO 0.8897
706 DPN 0.8896
707 F60 0.8896
708 FBM 0.8896
709 Q6T 0.8895
710 K82 0.8894
711 AAN 0.8894
712 DHI 0.8893
713 15L 0.8892
714 HX3 0.8892
715 1XA 0.8892
716 FIX 0.8890
717 B55 0.8890
718 4MB 0.8890
719 NYL 0.8889
720 657 0.8889
721 6HO 0.8889
722 M0W 0.8889
723 MNP 0.8889
724 AMS 0.8888
725 Q88 0.8888
726 49O 0.8887
727 8H8 0.8887
728 RAT 0.8886
729 NGA 0.8886
730 Z82 0.8885
731 ISN 0.8883
732 DJN 0.8883
733 F69 0.8883
734 HRM 0.8882
735 UFV 0.8882
736 BPU 0.8881
737 BZE 0.8880
738 MUA 0.8880
739 Q24 0.8880
740 A5P 0.8880
741 6L6 0.8879
742 SQ7 0.8878
743 FZM 0.8877
744 BNX 0.8876
745 ENO 0.8876
746 3ID 0.8875
747 VOH 0.8874
748 BVA 0.8874
749 IFP 0.8873
750 549 0.8873
751 NOK 0.8872
752 DMD 0.8872
753 3XR 0.8872
754 PXL 0.8872
755 ASC 0.8871
756 2AL 0.8871
757 5MB 0.8870
758 4XR 0.8870
759 EV3 0.8869
760 1AL 0.8869
761 5MI 0.8867
762 TOF 0.8866
763 2AK 0.8866
764 4AV 0.8866
765 FDB 0.8865
766 209 0.8864
767 PRL 0.8864
768 GTQ 0.8864
769 F2W 0.8863
770 HDL 0.8862
771 JCZ 0.8862
772 2MI 0.8861
773 0FR 0.8858
774 3BU 0.8857
775 CIY 0.8857
776 YPN 0.8856
777 TSU 0.8855
778 A2G 0.8854
779 E1K 0.8854
780 42C 0.8854
781 D2G 0.8854
782 RSV 0.8854
783 7ZE 0.8853
784 MWP 0.8853
785 GJZ 0.8853
786 X0W 0.8852
787 BHS 0.8852
788 P80 0.8851
789 258 0.8851
790 K34 0.8851
791 4M4 0.8849
792 GCB 0.8848
793 DX3 0.8848
794 DTR 0.8846
795 2D0 0.8845
796 QIC 0.8845
797 C9E 0.8844
798 B57 0.8842
799 OMD 0.8841
800 ROI 0.8839
801 4MA 0.8839
802 6R8 0.8838
803 FP1 0.8838
804 PPT 0.8838
805 VK3 0.8837
806 3C4 0.8837
807 6AI 0.8836
808 R9S 0.8836
809 ZIQ 0.8835
810 8GK 0.8835
811 MPK 0.8835
812 6ZX 0.8834
813 PZM 0.8834
814 OOG 0.8833
815 LTT 0.8832
816 O2A 0.8831
817 14O 0.8831
818 ES7 0.8830
819 6J9 0.8830
820 HNL 0.8830
821 82I 0.8829
822 IFL 0.8828
823 5JL 0.8828
824 F0J 0.8828
825 J38 0.8827
826 NF3 0.8827
827 54G 0.8827
828 MQG 0.8826
829 APZ 0.8826
830 HNK 0.8825
831 EWG 0.8825
832 261 0.8825
833 FWD 0.8825
834 XI7 0.8824
835 TPA 0.8824
836 1Y6 0.8822
837 SHI 0.8821
838 RNT 0.8820
839 5H1 0.8820
840 86L 0.8818
841 M1Z 0.8818
842 CWM 0.8818
843 GXY 0.8818
844 5V7 0.8818
845 KYN 0.8816
846 XAN 0.8815
847 G12 0.8814
848 0GZ 0.8814
849 LPK 0.8811
850 PAC 0.8811
851 492 0.8810
852 VC3 0.8809
853 80G 0.8808
854 F9P 0.8808
855 DBX 0.8808
856 QMP 0.8808
857 AJG 0.8807
858 HMH 0.8806
859 LGC 0.8806
860 R8V 0.8805
861 XM0 0.8805
862 KKN 0.8804
863 JXW 0.8804
864 9DG 0.8804
865 2K4 0.8802
866 YH7 0.8801
867 E3D 0.8800
868 RKV 0.8799
869 BA5 0.8796
870 M3E 0.8795
871 MS0 0.8795
872 GLU 0.8795
873 GVY 0.8793
874 7MK 0.8792
875 GAB 0.8792
876 NGT 0.8791
877 QWN 0.8791
878 2FG 0.8791
879 NOY 0.8790
880 YE6 0.8790
881 XQG 0.8790
882 QXW 0.8788
883 P92 0.8788
884 6CS 0.8787
885 537 0.8786
886 1XM 0.8786
887 FTV 0.8786
888 P72 0.8785
889 TAG 0.8784
890 3IT 0.8784
891 S24 0.8782
892 270 0.8781
893 H33 0.8780
894 BBK 0.8780
895 6AP 0.8779
896 7FF 0.8778
897 DHS 0.8777
898 QME 0.8775
899 SAN 0.8775
900 6HP 0.8774
901 HPP 0.8774
902 SOR 0.8773
903 PBN 0.8772
904 HNH 0.8772
905 46P 0.8772
906 149 0.8772
907 HHH 0.8771
908 F12 0.8771
909 27K 0.8771
910 JBZ 0.8771
911 9KT 0.8770
912 DVQ 0.8769
913 M3Q 0.8769
914 K7H 0.8769
915 3DO 0.8769
916 PRA 0.8769
917 PFF 0.8768
918 826 0.8768
919 NQ 0.8768
920 GC2 0.8767
921 DGJ 0.8766
922 2H5 0.8766
923 RXA 0.8764
924 9MG 0.8764
925 G2F 0.8763
926 ASO 0.8763
927 QQQ 0.8762
928 2UZ 0.8761
929 RUY 0.8761
930 ZSP 0.8761
931 DTY 0.8760
932 DA4 0.8760
933 174 0.8759
934 4HB 0.8758
935 STX 0.8758
936 9FH 0.8758
937 TU0 0.8756
938 78Y 0.8755
939 2ZQ 0.8754
940 9KZ 0.8754
941 KDG 0.8754
942 24B 0.8754
943 HL4 0.8753
944 FYU 0.8753
945 4R1 0.8752
946 HMU 0.8752
947 HSX 0.8751
948 53C 0.8751
949 ABF 0.8750
950 BOA 0.8750
951 QBK 0.8750
952 K25 0.8749
953 E3X 0.8749
954 ES0 0.8748
955 SR1 0.8748
956 LI6 0.8747
957 B85 0.8747
958 5TZ 0.8747
959 SOE 0.8747
960 TIY 0.8746
961 XFE 0.8745
962 GUN 0.8745
963 7B3 0.8744
964 LZ5 0.8743
965 SW7 0.8742
966 B60 0.8742
967 S0D 0.8742
968 G6P 0.8741
969 PYQ 0.8741
970 ZXD 0.8741
971 S8A 0.8741
972 AKH 0.8741
973 AES 0.8741
974 5M0 0.8740
975 NBG 0.8739
976 NSG 0.8738
977 5RG 0.8738
978 NSP 0.8738
979 LJ3 0.8737
980 FA3 0.8737
981 F06 0.8736
982 AJ1 0.8736
983 DIE 0.8735
984 67X 0.8735
985 FBS 0.8735
986 HBA 0.8735
987 AZA 0.8734
988 A5H 0.8734
989 X8D 0.8733
990 DBH 0.8733
991 TIU 0.8732
992 E35 0.8732
993 5AD 0.8731
994 DAH 0.8730
995 1BN 0.8730
996 PZI 0.8730
997 FE DB1 0.8730
998 WOO 0.8728
999 GLO 0.8728
1000 YZ9 0.8726
1001 XXG 0.8726
1002 IPD 0.8726
1003 4Z3 0.8725
1004 DC5 0.8725
1005 4VS 0.8725
1006 5WT 0.8725
1007 2LW 0.8724
1008 OVV 0.8724
1009 CC5 0.8723
1010 5RP 0.8723
1011 0J4 0.8723
1012 7NI 0.8721
1013 L03 0.8720
1014 STT 0.8719
1015 A6P 0.8718
1016 G1P 0.8718
1017 5B2 0.8718
1018 KLK 0.8718
1019 833 0.8717
1020 JTA 0.8717
1021 4J8 0.8717
1022 GLN 0.8717
1023 6BL 0.8715
1024 SWX 0.8715
1025 0UL 0.8715
1026 A2F 0.8714
1027 KJY 0.8712
1028 EMZ 0.8712
1029 M1A 0.8711
1030 67N 0.8710
1031 LIP 0.8709
1032 CNI 0.8708
1033 KGK 0.8707
1034 4FE 0.8707
1035 BL0 0.8706
1036 DPZ 0.8705
1037 0CU 0.8705
1038 DZA 0.8705
1039 MZM 0.8705
1040 CIT 0.8705
1041 0SY 0.8704
1042 3YP 0.8703
1043 4VP 0.8702
1044 K3Q 0.8700
1045 DBJ 0.8700
1046 MAQ 0.8700
1047 I4D 0.8700
1048 89J 0.8699
1049 BCP 0.8699
1050 FRU 0.8698
1051 5VJ 0.8698
1052 EE8 0.8697
1053 URO 0.8697
1054 TB8 0.8697
1055 2LP 0.8697
1056 MHK 0.8696
1057 6GU 0.8696
1058 JF6 0.8696
1059 JFJ 0.8694
1060 3HB 0.8693
1061 AL0 0.8693
1062 141 0.8692
1063 IF7 0.8691
1064 RMN 0.8691
1065 GNV 0.8690
1066 JR2 0.8689
1067 9PY 0.8688
1068 B21 0.8688
1069 G4D 0.8688
1070 HLD 0.8688
1071 TQU 0.8688
1072 0W8 0.8687
1073 7ZL 0.8687
1074 57O 0.8687
1075 20J 0.8685
1076 K68 0.8684
1077 3M0 0.8684
1078 3NT 0.8683
1079 XXP 0.8682
1080 HPS 0.8681
1081 1DW 0.8681
1082 FLV 0.8680
1083 QBP 0.8679
1084 B5D 0.8679
1085 JU2 0.8678
1086 II4 0.8678
1087 YIE 0.8678
1088 ZZT 0.8678
1089 1QV 0.8677
1090 3HA 0.8677
1091 8XQ 0.8677
1092 GLA 0.8676
1093 R1P 0.8675
1094 BY5 0.8674
1095 FLC 0.8674
1096