Receptor
PDB id Resolution Class Description Source Keywords
4NRC 1.86 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPL COMPOUND-3 N01186 HOMO SAPIENS SGC STRUCTURAL GENOMICS CONSORTIUM TRANSCRIPTION BROMODOMACETYLATED LYSINE BINDING PROTEIN KIAA1476 WALP4
Ref.: TARGETING LOW-DRUGGABILITY BROMODOMAINS: FRAGMENT B SCREENING AND INHIBITOR DESIGN AGAINST THE BAZ2B BROMODOMAIN. J.MED.CHEM. V. 56 10183 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:2003;
A:2002;
Invalid;
Invalid;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
2LY A:2001;
Valid;
none;
ic50 = 241 uM
199.227 C8 H9 N O3 S CNC(=...
15P A:2004;
Invalid;
none;
submit data
1529.83 C69 H140 O35 COCCO...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4XUB 1.98 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF THE BROMODOMAIN OF HUMAN BAZ2B IN COMPL BAZ2-ICR CHEMICAL PROBE HOMO SAPIENS TRANSCRIPTION BROMODOMAIN ACETYLATED LYSINE BINDING PROTEIKIAA1476 WALP4 SGC STRUCTURAL GENOMICS CONSORTIUM
Ref.: STRUCTURE ENABLED DESIGN OF BAZ2-ICR, A CHEMICAL PR TARGETING THE BROMODOMAINS OF BAZ2A AND BAZ2B. J.MED.CHEM. V. 58 2553 2015
Members (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 4XUB ic50 = 1.07 uM 43D C19 H18 N8 Cc1cn(nn1)....
2 4XUA ic50 = 26 uM 43C C21 H18 N6 Cc1cn(nn1)....
3 5MGF Kd = 54 uM 7MW C9 H11 N O3 CCC(=O)c1c....
4 5E9I - F60 C8 H7 N O c1cc(cc2c1....
5 6FGT - D9T C14 H21 N3 O2 CN1C=C(C=C....
6 4NRB ic50 = 38 uM 2LX C13 H17 N O3 CNC(=O)c1c....
7 6FH6 - D8Q C9 H13 N3 O2 CN1C=C(C=C....
8 5MGG - 7MU C7 H7 Cl N2 O CNC(=O)c1c....
9 5ORB - JR6 C16 H19 N3 O2 S Cn1c(c2c(n....
10 4NRC ic50 = 241 uM 2LY C8 H9 N O3 S CNC(=O)c1c....
11 6FH7 - EN2 C17 H18 F N3 O3 CN1C=C(C=C....
12 5E9K - 5KX C3 H3 Cl N2 c1cnc([nH]....
13 4NRA Kd = 65 uM 2LW C13 H13 Cl N2 O CC(=O)N1CC....
14 5MGE Kd = 87 uM 7MX C9 H10 Cl N O3 CCOC(=O)C1....
15 4NR9 - ALY C8 H16 N2 O3 CC(=O)NCCC....
16 5E9L - 6AI C7 H7 N3 c1cc2cn[nH....
17 5OR9 ic50 = 88 uM JR5 C18 H21 F N4 O3 S Cn1c(c2c(n....
18 5E74 Kd = 39 uM 5KH C25 H19 F3 N2 O3 Cc1ccc(cc1....
19 5E9M - BAE C6 H13 N O CC(C)(C)C(....
20 6FGU - D9Q C13 H19 N3 O2 CN1C=C(C=C....
21 5DYX - ADE C5 H5 N5 c1[nH]c2c(....
22 5DYU - MZ0 C4 H6 N2 O c1c([nH]cn....
23 5E73 Kd = 23 uM UO1 C19 H18 N2 O3 Cc1ccc(cc1....
70% Homology Family (23)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 4XUB ic50 = 1.07 uM 43D C19 H18 N8 Cc1cn(nn1)....
2 4XUA ic50 = 26 uM 43C C21 H18 N6 Cc1cn(nn1)....
3 5MGF Kd = 54 uM 7MW C9 H11 N O3 CCC(=O)c1c....
4 5E9I - F60 C8 H7 N O c1cc(cc2c1....
5 6FGT - D9T C14 H21 N3 O2 CN1C=C(C=C....
6 4NRB ic50 = 38 uM 2LX C13 H17 N O3 CNC(=O)c1c....
7 6FH6 - D8Q C9 H13 N3 O2 CN1C=C(C=C....
8 5MGG - 7MU C7 H7 Cl N2 O CNC(=O)c1c....
9 5ORB - JR6 C16 H19 N3 O2 S Cn1c(c2c(n....
10 4NRC ic50 = 241 uM 2LY C8 H9 N O3 S CNC(=O)c1c....
11 6FH7 - EN2 C17 H18 F N3 O3 CN1C=C(C=C....
12 5E9K - 5KX C3 H3 Cl N2 c1cnc([nH]....
13 4NRA Kd = 65 uM 2LW C13 H13 Cl N2 O CC(=O)N1CC....
14 5MGE Kd = 87 uM 7MX C9 H10 Cl N O3 CCOC(=O)C1....
15 4NR9 - ALY C8 H16 N2 O3 CC(=O)NCCC....
16 5E9L - 6AI C7 H7 N3 c1cc2cn[nH....
17 5OR9 ic50 = 88 uM JR5 C18 H21 F N4 O3 S Cn1c(c2c(n....
18 5E74 Kd = 39 uM 5KH C25 H19 F3 N2 O3 Cc1ccc(cc1....
19 5E9M - BAE C6 H13 N O CC(C)(C)C(....
20 6FGU - D9Q C13 H19 N3 O2 CN1C=C(C=C....
21 5DYX - ADE C5 H5 N5 c1[nH]c2c(....
22 5DYU - MZ0 C4 H6 N2 O c1c([nH]cn....
23 5E73 Kd = 23 uM UO1 C19 H18 N2 O3 Cc1ccc(cc1....
50% Homology Family (389)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6JJ3 ic50 = 100 nM BS6 C23 H25 N5 O4 S CN1CCN(CC1....
2 6P05 ic50 = 5.9 nM YF2 C30 H28 N6 O3 S CCS(=O)(=O....
3 4IOO - BAE C6 H13 N O CC(C)(C)C(....
4 5I88 Kd = 250 nM 69G C20 H21 N3 O2 C/C=C/CN1C....
5 5DX4 Kd = 0.137 uM E0C C20 H17 Br N2 O4 S CCN1c2ccc(....
6 6JJB ic50 = 49.5 nM BT0 C19 H16 N2 O4 S CN1c2ccc(c....
7 3JVK Kd = 118 uM GLY GLY ALY ALA PRO ARG LYS GLN n/a n/a
8 4HBX ic50 = 1.9 uM 14X C13 H17 N3 O3 S CN1Cc2cc(c....
9 4NUE Ki = 0.15 uM NUE C19 H19 N5 O3 S Cc1cc(c(c(....
10 6SB8 Kd = 0.07 uM L45 C21 H27 N3 O5 S CCN(CC)S(=....
11 5Y94 Kd = 164 nM 8QC C16 H16 Br N3 O4 S Cc1c2cc(c(....
12 6DMJ - 53W C27 H32 N4 O3 Cc1c(c(on1....
13 4HXR ic50 = 4.1 uM 1A4 C13 H10 N2 O3 S3 c1cc(cc(c1....
14 6DML - 9BM C25 H26 N4 O4 Cc1c(c(on1....
15 5TI5 ic50 = 41 uM 7CN C16 H13 Br N2 O3 S c1cc(cc(c1....
16 6VUJ ic50 = 35.2 uM RLY C23 H30 N2 O5 S CCN(CC)S(=....
17 6X7B ic50 = 27 nM ZVP C26 H24 N4 O5 S c1cc(cnc1)....
18 4O7C ic50 = 10 uM 2RK C22 H23 N5 O C1CNCCC1C2....
19 4IOQ - BAQ C4 H7 N O C1CC(=O)NC....
20 4HXK - 1AJ C11 H11 N3 O S c1csc2c1CN....
21 6S6K Kd = 0.18 uM KXK C24 H31 N3 O5 S Cc1c2c(c([....
22 2YEL ic50 = 15.5 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
23 6RWJ Kd = 6.41 uM KLK C12 H16 N2 O2 Cc1c2c(c([....
24 6SA2 Kd = 0.08 uM L25 C22 H27 N3 O6 S Cc1c2c(c([....
25 6XV7 - O2Q C14 H13 F2 N5 Cc1nnc2n1n....
26 4BW4 ic50 = 631 nM 9B6 C22 H16 F3 N5 O4 Cc1c(c(on1....
27 4O72 ic50 = 1 uM 2R4 C25 H19 N O3 S c1ccc2c(c1....
28 5F63 Kd = 12 nM 5W2 C28 H35 Cl F N7 O3 S Cc1cnc(nc1....
29 5HLS ic50 = 0.039 uM 62G C20 H16 Cl N3 O2 Cc1c-2c(on....
30 4HBW ic50 = 4.8 uM 14Z C11 H15 N3 O3 S CCNS(=O)(=....
31 4OGI Kd = 37 nM R78 C28 H39 N7 O3 CC[C@@H]1C....
32 6WW8 - YR0 C31 H32 N6 O4 S CN(C)C(=O)....
33 5TI7 ic50 = 11 uM 7CQ C17 H19 Br N2 O4 S COc1ccc(cc....
34 4J0S ic50 = 0.382 uM 1H3 C18 H17 N O3 Cc1c(c(on1....
35 6Q3Y Kd = 54 nM HG5 C30 H38 N6 O2 CC[C@@H]1C....
36 6SAJ Kd = 0.05 uM L2Z C23 H27 N3 O6 S Cc1c2c(c([....
37 4F3I Kd = 36.1 nM 0S6 C20 H19 Cl N4 O2 S Cc1c(sc-2c....
38 4QZS Kd = 89 nM JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
39 6AFR ic50 = 70 nM 9E3 C13 H10 F N3 O c1cc2c(ccc....
40 4WIV Kd = 550 nM 3P2 C21 H23 N5 O Cc1c(c(on1....
41 6VUF ic50 = 147 uM RLV C14 H20 N2 O3 S CCCNS(=O)(....
42 3P5O Kd = 55.2 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
43 4UIX ic50 = 0.00000001 M TVU C22 H24 N2 O6 S2 CN1C=C(c2c....
44 4HXS ic50 = 4.1 uM 1A3 C16 H14 N2 O3 S2 c1ccc(cc1)....
45 5HM0 ic50 = 0.44 uM 62V C18 H13 Cl N2 O Cc1c-2c(on....
46 5DLX Kd = 2 uM 5D2 C25 H33 Cl N8 O Cc1nnc2n1n....
47 5TI2 ic50 = 24 uM 7CJ C16 H15 F N2 O3 S c1cc(cc(c1....
48 5D3H Kd = 7.9 uM 57G C20 H27 N3 O6 S CCc1c(c([n....
49 6E4A Kd = 44 nM HRY C29 H34 Cl N7 O CN1C=C(C=C....
50 4MEP ic50 = 4.7 uM 24Y C19 H14 Cl N5 O Cc1cccnc1n....
51 4YH4 ic50 = 26 uM Y81 C20 H15 N3 O2 c1ccc(cc1)....
52 5D3N Kd = 9.2 uM L40 C18 H23 N3 O4 S CCc1c(c([n....
53 6C7R Kd = 2.2 nM EO4 C24 H25 N7 O2 Cc1c(c(on1....
54 6WGX ic50 = 0.15 uM U0D C31 H36 F3 N7 Cc1cc(cc(c....
55 6HOV - FER C10 H10 O4 COc1cc(ccc....
56 5D26 Kd = 0.81 uM L28 C19 H26 N4 O5 S CCc1c(c([n....
57 3MUK Kd = 380 uM ALA THR PRK ALA ALA ARG LYS SER n/a n/a
58 4J3I Kd = 8.93 uM 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
59 6X7D ic50 = 388 nM UT4 C19 H18 N2 O4 S c1cc2c(cc1....
60 4QB3 Kd = 3.4 uM 30M C17 H21 N3 O2 CC(=O)NCCC....
61 4LZS Kd = 16 uM L46 C11 H16 N2 O2 CCc1c(c([n....
62 6HDQ ic50 = 5.01 uM FZE C30 H37 F2 N5 O Cc1cc(cnc1....
63 4O71 ic50 = 18 uM CPB C21 H20 Cl N O5 C[N@]1CC[C....
64 4CFL Kd = 1.33 uM 8DQ C19 H18 N2 O2 c1ccc(cc1)....
65 4C67 - L5S C15 H12 N4 S Cc1nnc2n1-....
66 6V1K - 5SW C20 H23 N3 O3 CN1C=C(c2c....
67 4QR3 ic50 = 1.4 uM BNJ C14 H16 N2 O3 S2 c1cc(cc(c1....
68 4ZC9 - 4MW C38 H37 Cl N8 O7 S Cc1c(sc-2c....
69 4MEO - 25V C18 H16 N2 O2 Cc1cc(c2cc....
70 6UVM Kd = 510 uM QJA C11 H13 N O S2 CC(=O)N1CC....
71 4LRG ic50 = 0.026 uM 1XB C20 H18 Cl N3 O2 S Cc1c(sc-2c....
72 6CKS ic50 = 0.015 uM F5Y C23 H23 N3 O4 S CCS(=O)(=O....
73 6DJC Ki = 232.8 nM CF6 C48 H54 Cl2 N10 O2 S2 Cc1c(sc-2c....
74 5TI3 ic50 = 44 uM 7CG C16 H14 Br2 N2 O3 S c1cc(cc(c1....
75 4HXP - 1A5 C10 H10 N2 O3 c1cc(ccc1C....
76 6PSB ic50 = 24 uM Y18 C17 H19 N3 O2 CN1C[C@H](....
77 6CD4 ic50 = 5.14 uM EX1 C33 H42 N8 O3 CC(C)N1c2c....
78 4O7E ic50 = 5.7 uM 2RN C20 H15 N3 O c1ccc(cc1)....
79 4O74 ic50 = 0.025 uM R78 C28 H39 N7 O3 CC[C@@H]1C....
80 4BW2 ic50 = 6.31 uM UTH C24 H24 N4 O3 Cc1c(c(on1....
81 5CS8 ic50 = 2.29 uM EB8 C21 H18 N2 O5 S CCN1c2ccc(....
82 3U5J Kd = 2.46 uM 08H C17 H13 Cl N4 Cc1nnc2n1-....
83 5EIS Kd = 1.8 uM 5OU C14 H13 Cl N4 O2 CCn1cnc2c1....
84 6FO5 Kd = 0.19 uM DZH C25 H26 N6 O5 S CCn1cnc2c1....
85 6V1L Kd = 418 nM 5U6 C20 H23 N3 O3 CN1C=C(c2c....
86 3U5L Kd = 0.64 uM 08K C17 H14 Cl N5 Cc1nnc2n1-....
87 4QR4 ic50 = 0.25 uM BNK C14 H15 Cl N2 O3 S2 c1cc(c(cc1....
88 4O7A ic50 = 19 uM 2RF C16 H10 Cl2 N2 O3 c1cc(cc(c1....
89 5F61 Kd = 35 nM 5W0 C26 H34 F N7 O2 S Cc1cnc(nc1....
90 4HXN - 1A7 C9 H6 F N O S c1ccc(c(c1....
91 6DL2 Ki = 33 nM GUJ C17 H17 N3 O S Cc1c(c2c(s....
92 5Z5U - 96U C12 H10 N4 O2 c1cn(cn1)c....
93 5TI4 ic50 = 26 uM 7CM C16 H14 Cl F N2 O3 S c1cc(cc(c1....
94 5Y8C ic50 = 0.16 uM 8P9 C16 H15 Cl N2 O5 S Cc1c2cc(c(....
95 4NUD Ki < 0.0845 uM NUD C18 H17 N5 O3 S Cc1cc(c(cc....
96 4O7B ic50 = 20 uM 2RJ C26 H26 F N5 O Cc1cccc(c1....
97 5CPE ic50 = 0.45 uM EB2 C20 H24 N2 O3 S CCN1c2ccc(....
98 5MLI ic50 = 130 uM 82I C6 H8 Cl N3 O CNC1=C(C(=....
99 5DW2 Kd = 1.44 uM 5GD C24 H29 N3 O4 Cc1cc(cc(c....
100 5D3P Kd = 7.4 uM 57E C19 H21 N3 O4 S CCc1c(c([n....
101 4PCE ic50 = 7 uM 2N0 C17 H19 N O CCc1cc2c(n....
102 5D25 Kd = 0.46 uM 56M C19 H25 N3 O5 S CCN(CC)S(=....
103 5DLZ Kd = 1.8 uM 5D1 C28 H35 N3 O3 Cc1cccc(c1....
104 5Y8W ic50 = 0.23 uM 8PU C15 H13 Br N2 O5 S Cc1c2cc(c(....
105 4J0R ic50 = 0.386 uM 1H2 C18 H17 N O3 Cc1c(c(on1....
106 6MH7 ic50 = 1.3 uM JQY C26 H27 F N6 Cc1ccc(cc1....
107 5F60 Kd = 43 nM 5VZ C26 H34 Cl N7 O2 S Cc1cnc(nc1....
108 5Z5V ic50 = 287 nM 96X C15 H14 N4 O2 CC(=O)Nc1c....
109 4HXO - 1A6 C11 H10 N4 O S Cc1cc(on1)....
110 5CRM ic50 = 1.09 uM EB5 C15 H16 N2 O3 S CCNS(=O)(=....
111 6YQN ic50 = 0.72 uM P8T C32 H28 Cl N7 O2 S Cc1c(sc-2c....
112 5CQT Kd = 0.124 uM EB3 C19 H22 N2 O3 S CCN1c2ccc(....
113 5KHM Ki = 5.012 nM XNH C25 H33 N7 O3 C[C@@H]1C(....
114 6XV3 - O2B C28 H33 N9 O Cc1nnc2n1c....
115 4Z1S ic50 = 0.79 uM 559 C23 H21 Cl N6 Cc1nnc2n1-....
116 4MR3 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
117 5MKZ ic50 = 20 uM RNK C11 H12 Cl N3 O S Cc1ccsc1CN....
118 5ULA Ki = 77 nM 5MJ C20 H19 Cl N2 O3 CC1=C(CCC1....
119 4O78 ic50 = 4.6 uM SAV C21 H22 N6 O3 Cc1c2ccc(c....
120 6XVC - O32 C22 H21 N5 O2 Cc1nnc2n1c....
121 4OGJ Kd = 164 nM 2TA C27 H36 N6 O3 S Cc1cnc(nc1....
122 5A85 ic50 = 5.01 uM 78J C21 H30 N4 O2 CC1=Cc2ccn....
123 5TI6 ic50 = 21 uM 7CO C16 H14 F2 N2 O3 S c1cc(cc(c1....
124 6MAU - JBS C30 H32 N6 O3 Cc1c(c(on1....
125 6S4B Kd = 0.14 uM KUH C22 H29 N3 O5 S CCN(CC)S(=....
126 6Q3Z Kd = 44 nM HG8 C29 H38 N6 O2 S CC[C@@H]1C....
127 6V0U Kd = 392 nM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
128 6VUC ic50 = 144 uM RLS C16 H22 N2 O3 S CN1C[C@H](....
129 4MR4 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
130 4QR5 ic50 = 0.06 uM BNM C18 H21 N3 O4 S2 c1c(cc(cc1....
131 4MEQ - 25O C12 H11 N5 Cc1cc(n2c(....
132 4O77 ic50 = 2.5 uM 2RE C20 H14 F N3 O c1cc(ccc1c....
133 6XUZ - O1W C24 H33 N9 O2 Cc1nnc2n1c....
134 5EI4 ic50 = 26.4 uM 5NV C17 H17 Cl N8 O2 S CCn1c(nc2c....
135 5CY9 Kd = 0.218 uM E0A C17 H20 N2 O3 S CCCCS(=O)(....
136 6MH1 ic50 = 1.7 uM JQP C26 H27 F N6 Cc1cc(cc(c....
137 5CRZ ic50 = 0.45 uM EB7 C19 H14 Cl F N2 O3 S CCN1c2ccc(....
138 5Y93 ic50 = 2.27 uM 8Q9 C23 H27 Br N4 O7 S Cc1c2cc(c(....
139 5AD2 Kd = 63 nM ETU C24 H30 Cl N7 O2 C[C@@H]1C(....
140 4E96 ic50 = 0.22 uM 0NS C16 H17 N3 O4 S CN1Cc2cc(c....
141 5D0C Kd = 2.34 uM E0B C21 H25 N3 O4 S CCN1c2ccc(....
142 4O7F ic50 = 13 uM 2RQ C25 H24 F N5 O2 COc1ccccc1....
143 5CP5 Kd = 1.234 uM EB0 C19 H15 F N2 O3 S CCN1c2ccc(....
144 4CFK Kd = 1.83 uM LY2 C19 H17 N O3 c1ccc(cc1)....
145 5D3R - 57C C23 H31 N3 O4 S CCCc1c(c([....
146 4NUC Ki = 0.91 uM 435 C19 H18 N4 O3 S Cc1cc(cc(c....
147 4HXL ic50 = 2.2 uM 1A9 C22 H25 N3 O4 S3 c1cc(sc1)S....
148 6CIY ic50 = 0.41 uM F3J C34 H42 N8 O3 CN1CCN(CC1....
149 5D3L Kd = 0.88 uM 57F C21 H29 N3 O5 S CCc1c(c([n....
150 4A9L - P9L C14 H19 N3 O4 S CN1Cc2cc(c....
151 4XYA Kd = 1370 nM 43S C13 H8 Br N5 O c1coc2c1cc....
152 4C66 - H4C C17 H16 Cl N4 S CCc1cc2c(s....
153 6UWU ic50 ~ 70 nM QKP C27 H34 N2 O6 Cc1cc(cc(c....
154 4O76 ic50 = 0.13 uM 1M3 C26 H35 N7 O2 S Cc1cnc(nc1....
155 5LJ2 ic50 = 10 uM 6XW C25 H32 N6 O4 S CC1=Cc2c(c....
156 6CD5 - R4L C35 H44 N8 O3 CN1CCN(CC1....
157 5I80 Kd = 62 nM 67B C17 H17 N3 O2 CN1C=C(c2c....
158 4O75 ic50 = 21 uM 2RC C23 H26 F N6 O9 P CC1(C(=O)N....
159 5NNF - PHE LEU PRO HIS ALY TYR ASP VAL LYS LEU n/a n/a
160 3ZYU ic50 = 0.1 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
161 4Z1Q ic50 = 0.015 uM 558 C23 H21 Cl N6 Cc1nnc2n1-....
162 6SA3 Kd = 0.42 uM L2N C23 H30 N4 O5 S Cc1c2c(c([....
163 5IGK Kd = 41.8 nM BMF C17 H20 N6 O4 S CCOC(=O)Nc....
164 5Y1Y ic50 = 0.98 uM HNQ C9 H6 N2 O3 c1cc2c(ccc....
165 5Z5T - 96R C12 H10 N4 O c1cc2c(cc(....
166 6V1U - QMG C20 H19 N3 O2 Cc1ccc(cc1....
167 5KDH Ki = 0.37 uM 6RX C18 H17 N3 O4 CCN1C2=C([....
168 4PS5 ic50 = 0.29 uM 2TA C27 H36 N6 O3 S Cc1cnc(nc1....
169 5D24 Kd = 5.8 uM L26 C18 H21 N3 O4 CCc1c(c([n....
170 5ACY Kd = 6.4 nM 9S3 C30 H35 N3 O C[C@H]1C[C....
171 5HCL ic50 = 6 mM 5Y9 C4 H9 N O CC(=O)N(C)....
172 5COI ic50 = 2.58 uM 55K C20 H22 N2 O5 S CCN1c2ccc(....
173 6UWX Kd = 290 uM QKD C12 H17 N O2 S2 CCOC(=O)N1....
174 5Y8Y Kd = 82 nM 8PX C16 H15 Br N2 O5 S Cc1c2cc(c(....
175 4HXM ic50 = 0.79 uM 1A8 C17 H17 N3 O4 S3 CCCC(=O)Nc....
176 5F62 Kd = 6.8 nM 5W1 C26 H33 Cl F N7 O2 S Cc1cnc(nc1....
177 5D3S Kd = 1.3 uM 579 C20 H24 F N3 O5 S CCc1c(c([n....
178 6YQP ic50 = 1.35 uM P8N C29 H27 Cl N6 O3 S Cc1c(sc-2c....
179 6AJX Kd = 9.1 uM HCC C15 H12 O4 c1cc(ccc1C....
180 4LYW Kd = 237 nM 21Q C20 H27 N3 O5 S CCc1c(c([n....
181 4HBV ic50 = 23 uM 15E C9 H9 Br N2 O CN1Cc2cc(c....
182 5LUU Kd = 8.63 uM 77X C15 H17 N3 O CCC(=O)N1C....
183 4YH3 ic50 = 26 uM Y80 C24 H20 N2 O3 COc1ccc(cc....
184 6AJV Kd = 9.1 uM HCC C15 H12 O4 c1cc(ccc1C....
185 6CZV ic50 = 0.23 uM FOY C17 H16 N2 O2 Cc1c(c(on1....
186 4X2I ic50 = 0.35 uM 3X0 C18 H17 Cl N4 Cc1nnc2n1-....
187 6CJ1 ic50 = 6.31 uM FND C34 H44 N8 O3 CC[C@H](C)....
188 5F5Z Kd = 86 nM 5VY C26 H35 N7 O2 S Cc1cnc(nc1....
189 6UVJ Kd = 20 uM QJ1 C11 H15 N O2 S2 COC(=O)N1C....
190 6FNX ic50 = 12.6 uM DYZ C14 H14 N4 O2 CCn1cnc2c1....
191 4HBY ic50 = 4.4 uM 13F C15 H15 N3 O3 S CN1Cc2cc(c....
192 5D3J Kd = 5.7 uM L33 C20 H27 N3 O4 S CCc1c(c([n....
193 6AJY Kd = 5.3 uM A0R C16 H14 O4 COc1ccccc1....
194 3MUL - GLY GLY BTK ALA PRO ARG LYS GLN n/a n/a
195 4LR6 ic50 = 33 uM 1XA C10 H10 N2 O Cc1c(c(on1....
196 5AD3 Kd = 7.9 nM K6K C26 H30 N10 O3 CN(CCOc1cc....
197 4PCI ic50 = 7.5 uM 2NJ C16 H16 N2 O CN1c2ccccc....
198 5D3T Kd = 12 uM 56Y C19 H23 N3 O3 CCc1c(c([n....
199 6SAH Kd = 0.26 uM L2W C23 H29 N3 O5 S Cc1c2c(c([....
200 5LJ1 ic50 > 0.0000316 M 6XX C28 H35 F2 N5 O3 Cc1cc(cnc1....
201 4O70 ic50 = 19 uM 1QK C21 H29 N6 O2 CCc1cnn2c1....
202 4XY9 Kd = 4651 nM 43U C12 H10 Br N5 O COc1ccc(cc....
203 3MXF - JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
204 5CFW Kd = 0.78 uM 53W C27 H32 N4 O3 Cc1c(c(on1....
205 5A5S ic50 = 1.3 uM NP8 C20 H23 N5 O2 CC1=Cc2c(c....
206 4UIY ic50 = 0.00000001 M 5V2 C21 H20 F3 N3 O3 S2 CN1C=C(c2c....
207 6PS9 ic50 = 79 uM Y17 C18 H21 N3 O2 CN1C[C@@H]....
208 4LZR Kd = 20 uM LOC C22 H25 N O6 CC(=O)N[C@....
209 6PRT ic50 = 2120 uM OWA C8 H13 N O3 CN1C[C@H](....
210 4BW1 ic50 = 1.26 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
211 6YQO ic50 = 4.53 uM P8Q C33 H36 Cl N7 O4 S Cc1c(sc-2c....
212 4MEN - 25K C15 H17 N5 Cc1ccc(cc1....
213 6CIS ic50 = 0.3 uM X26 C37 H48 N8 O3 CC(C)Oc1cc....
214 6CKR ic50 = 0.05 uM F5V C21 H20 N4 O3 S Cn1cc(cn1)....
215 4UIZ ic50 = 0.00001995 M N1D C22 H25 N3 O6 S2 CN1C=C(c2c....
216 5KJ0 ic50 = 130 nM 6TB C29 H41 N7 O3 CC[C@@H]1C....
217 4KV1 - THR PHE ALY SER ILE MET LYS n/a n/a
218 5EGU Kd = 1.4 uM 5NQ C23 H32 N8 O2 S CCCCc1c(nc....
219 5Y8Z ic50 = 0.62 uM 8Q3 C16 H15 Br N2 O4 S Cc1cc2c(cc....
220 6VUB ic50 = 629 uM RLG C11 H13 N O CN1C[C@H](....
221 4BW3 ic50 = 501 nM 9BM C25 H26 N4 O4 Cc1c(c(on1....
222 3U5K - 08J C18 H13 Cl F N3 Cc1ncc2n1-....
223 6FGH - 6RZ C10 H16 N2 O2 S Cc1c(cccn1....
224 6FG6 - D8Q C9 H13 N3 O2 CN1C=C(C=C....
225 6FGG Kd = 17 uM D9B C18 H20 N4 O4 CN1C=C(C=C....
226 5MGJ Kd = 51 uM 7MX C9 H10 Cl N O3 CCOC(=O)C1....
227 6FGV - D9T C14 H21 N3 O2 CN1C=C(C=C....
228 6FGL ic50 = 24 uM UO1 C19 H18 N2 O3 Cc1ccc(cc1....
229 5OR8 - JR4 C17 H18 F N3 O3 S Cc1cc2c(cc....
230 5FE0 - ALY C8 H16 N2 O3 CC(=O)NCCC....
231 5LVR Kd = 250 uM 78Y C10 H10 N4 O Cc1c(nn(n1....
232 5FDZ Kd = 6.8 uM 5X0 C21 H24 N2 O5 CNC(=O)c1c....
233 5FE1 - 12Q C10 H9 N O CN1c2ccccc....
234 5FE6 Kd = 6910 uM 5WZ C9 H16 N2 O C1CC1C(=O)....
235 5FE2 - 5WV C9 H9 N O CN1Cc2cccc....
236 5FE7 Kd = 488 uM 5WU C10 H14 N2 O2 Cc1c2c(n(n....
237 5FE8 - 5WT C13 H14 N2 O2 CC1=CC(=O)....
238 5FE4 - 5WY C9 H9 N O3 c1cc(c2c(c....
239 5FE9 Kd = 20.98 uM 5WS C12 H14 N2 O3 S CC1=CC(=O)....
240 5FE5 - 2QC C9 H9 N3 S c1cc(ccc1C....
241 5MKX ic50 = 20 uM 82I C6 H8 Cl N3 O CNC1=C(C(=....
242 5LVQ Kd = 73 uM 2LX C13 H17 N O3 CNC(=O)c1c....
243 5FE3 - 5WX C8 H8 N2 O2 COc1cccc2c....
244 6C7Q - EO1 C25 H23 N7 O2 Cc1c(c(on1....
245 2YEM ic50 = 15.5 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
246 5JWM ic50 = 3.09 nM 6ON C54 H66 Cl2 N10 O9 S2 Cc1c(sc-2c....
247 5UOO Ki = 1.4 nM 8FV C26 H21 N5 O2 Cc1c(c(on1....
248 3QZS Kd = 99 uM LYS GLY GLY ALA ALY ARG HIS ARG LYS VAL n/a n/a
249 3QZT - LYS GLY GLY ALA ALY ARG HIS ARG LYS VAL n/a n/a
250 5U6V ic50 = 21 nM 7WY C22 H19 Cl N6 Cc1c-2n(nn....
251 5O3A - 31P C23 H23 Cl N4 O3 CC[C@H]([C....
252 5DFD - 59E C23 H21 N5 O3 Cc1nnc2n1-....
253 5XHK - LDR C13 H9 N O c1ccc2c(c1....
254 5O3D - 9J5 C23 H23 Cl N4 O3 CC[C@H]([C....
255 6YTM Kd = 65 nM PMW C22 H25 Cl N4 O2 S CC[C@H]([C....
256 6VIY Ki = 1.1 nM QYY C27 H29 N3 O5 S CCNC(=O)c1....
257 5IG6 Kd = 213.7 uM 6B3 C27 H18 N2 O4 c1ccc2c(c1....
258 5O3G - 9J8 C25 H26 Cl N5 O2 CCNC(=O)[C....
259 4J1P Kd = 0.206 uM 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
260 5O3I - 9HN C27 H29 Cl N4 O3 Cc1nnc2n1-....
261 5UEW - 87D C20 H20 N2 O5 S CN1C=C(C(=....
262 5O3B - 9HZ C24 H23 Cl N4 O3 Cc1nnc2n1-....
263 5O3E - 9HW C23 H24 Cl N5 O2 CCNC(=O)[C....
264 3ONI - JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
265 6K04 Ki = 3.1 nM CQF C22 H21 Cl N6 Cc1nnc2n1-....
266 5O39 - 31O C22 H21 Cl N4 O3 Cc1nnc2n1-....
267 5O3H - 9HQ C23 H24 Cl N5 O2 CCNC(=O)[C....
268 5O3C - 9J2 C22 H21 Cl N4 O3 Cc1nnc2n1-....
269 4MR6 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
270 6MOA Kd = 2.5 nM JW4 C25 H22 N4 O Cc1ccc2c(c....
271 5DW1 ic50 = 0.08 uM 5GD C24 H29 N3 O4 Cc1cc(cc(c....
272 5DFC - EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
273 4MR5 - 1K0 C20 H22 N2 O5 Cc1cc(cc(c....
274 5O3F - 9HT C24 H26 Cl N5 O2 CC[C@H]([C....
275 2WP1 - LYS ALA PRO ARG ALY GLN LEU ALA THR LYS n/a n/a
276 4FLP Kd = 190.1 nM JQ1 C23 H26 Cl N4 O2 S Cc1c(sc-2c....
277 4KCX Kd = 37 uM 1QK C21 H29 N6 O2 CCc1cnn2c1....
278 4A9I - P9I C15 H13 N2 O C/C(=C/1C=....
279 4UYH ic50 = 0.00000001 M 9S3 C30 H35 N3 O C[C@H]1C[C....
280 4A9H - TVP C12 H15 N O C[C@H]1CCc....
281 4A9F - MB3 C5 H9 N O CN1CCCC1=O
282 4ALG ic50 = 0.5 uM 1GH C23 H21 N5 O3 Cc1c(c(on1....
283 2YEK ic50 = 32.5 nM EAM C22 H22 Cl N5 O2 CCNC(=O)C[....
284 2YDW Kd = 46 nM WSH C25 H21 N5 O2 Cc1nnc2n1-....
285 4A9J - TYL C8 H9 N O2 CC(=O)Nc1c....
286 4A9M ic50 = 0.5 uM P9M C17 H22 N2 O3 S Cc1ccc(cc1....
287 4ALH - A9P C11 H11 N O Cc1c(c(on1....
288 4A9E - 3PF C9 H10 N2 O CN1Cc2cccc....
289 4A9O - A9O C12 H13 N O CCc1c(c(no....
290 4AKN ic50 = 0.79 uM S5B C25 H25 N3 O3 Cc1c(c(on1....
291 4A9N ic50 = 1.5 uM A9N C15 H16 N2 O3 S Cc1ccc(cc1....
292 4KV4 - THR PHE ALY SER ILE MET LYS n/a n/a
293 5UEZ Ki = 970 nM 89G C18 H16 N2 O3 CN1C(=O)C=....
294 6VIX Ki = 1.3 nM QYV C24 H21 F2 N3 O5 S CCNC(=O)c1....
295 5UF0 Ki = 160 uM 89J C12 H13 N3 O CNC1=CC(=O....
296 5UEU - 0S6 C20 H19 Cl N4 O2 S Cc1c(sc-2c....
297 4Z93 Kd = 44.6 nM 4LD C24 H23 N5 O2 Cc1c(c(n[n....
298 5UEY Ki = 5.1 nM 88M C22 H24 F2 N2 O5 S CCOC1=CC(=....
299 5UEX Ki = 1.5 nM 89D C24 H26 F2 N2 O5 S CCS(Nc1ccc....
300 5I8B ic50 = 0.11 uM 69F C23 H22 N2 O2 C[C@@H]1CC....
301 5I8G Kd = 0.03 uM 69E C22 H22 N6 O C[C@@H]1CC....
302 5N18 Kd = 2.1 uM 8HZ C21 H19 N3 O Cc1ccc(cc1....
303 5MLJ Ki = 1.4 nM 9ST C17 H21 Br N4 O CN1C[C@H](....
304 6J3P Kd = 105 nM B8O C21 H25 N5 O3 CN1C[C@H](....
305 6AXQ ic50 = 99000 nM C2Y C10 H9 N O2 COC(=O)c1c....
306 5DBM Kd = 0.35 uM 58N C17 H22 N4 O C[C@@H]1CC....
307 5LPM Kd = 2.77 uM 71Y C20 H23 Cl N2 O3 CCc1c(c([n....
308 5NRW - 96N C21 H22 N2 O2 CCc1c(c([n....
309 3P1D - MB3 C5 H9 N O CN1CCCC1=O
310 5LPJ Kd = 10.1 uM XDM C17 H19 Cl N2 O2 CCc1c(c([n....
311 6FQO ic50 = 0.14 uM E2T C26 H24 N2 O6 CCOc1ccc(c....
312 4TQN Kd = 0.77 uM UL4 C18 H17 N O5 CCOc1ccc(c....
313 6FRF ic50 = 0.04 uM E3T C26 H24 N2 O5 CCOc1ccc(c....
314 5TB6 Kd = 1.53 uM 77X C15 H17 N3 O CCC(=O)N1C....
315 5MQK - QPR C11 H11 N O CC(=O)c1cn....
316 5MQG - F31 C9 H11 N O2 CC(=O)c1cc....
317 5I83 ic50 = 4.1 uM 68Y C18 H20 N2 O2 C[C@@H]1CC....
318 4A9K - TYL C8 H9 N O2 CC(=O)Nc1c....
319 5I86 ic50 = 0.53 uM 69A C18 H19 N3 O2 C[C@@H]1CC....
320 6FR0 ic50 = 0.146 uM E3H C27 H26 N2 O6 CCN1C(=O)C....
321 5NU5 Kd = 0.47 uM 99E C21 H22 N2 O4 CCc1c(c([n....
322 5LPK Kd = 3.06 uM XDM C17 H19 Cl N2 O2 CCc1c(c([n....
323 5MME Kd = 1.4 uM 8Q6 C20 H21 N O6 CCOc1ccc(c....
324 5I89 ic50 = 0.033 uM 69B C21 H22 N4 O C[C@@H]1CC....
325 5NU3 Kd = 0.23 uM 99E C21 H22 N2 O4 CCc1c(c([n....
326 5OWK - 7MX C9 H10 Cl N O3 CCOC(=O)C1....
327 6AY5 ic50 = 69 nM C3V C22 H20 F2 N4 O S Cn1cc(cn1)....
328 5LPL Kd = 12 uM 71X C20 H23 Cl N2 O3 CCc1c(c([n....
329 6FQU ic50 = 2.2 uM E3B C21 H23 F2 N O2 CCOc1ccc(c....
330 6DMK - 2LL C26 H30 N4 O2 Cc1c(c(on1....
331 5MMG Kd = 0.97 uM UT0 C19 H20 N2 O4 S CCOc1ccc(c....
332 5MPN Kd = 0.085 uM YE5 C17 H16 N4 O2 CCOc1ccc(c....
333 5J0D Kd = 134 nM 6F9 C27 H35 N3 O5 CCC(=O)N1C....
334 6AY3 ic50 = 9.5 nM C3J C24 H23 F2 N5 O CNC(=O)c1c....
335 5MPK Kd = 0.003 uM 0BC C21 H18 N6 O3 S CCOc1ccc(c....
336 5CGP Kd = 0.12 uM 53W C27 H32 N4 O3 Cc1c(c(on1....
337 4BJX ic50 = 22 nM 73B C25 H23 Cl N2 O3 C[C@H]1C[C....
338 4UYD ic50 = 79.4 uM V1T C10 H11 N3 O2 CN1c2ccc(c....
339 4XUB ic50 = 1.07 uM 43D C19 H18 N8 Cc1cn(nn1)....
340 4XUA ic50 = 26 uM 43C C21 H18 N6 Cc1cn(nn1)....
341 5MGF Kd = 54 uM 7MW C9 H11 N O3 CCC(=O)c1c....
342 5E9I - F60 C8 H7 N O c1cc(cc2c1....
343 6FGT - D9T C14 H21 N3 O2 CN1C=C(C=C....
344 4NRB ic50 = 38 uM 2LX C13 H17 N O3 CNC(=O)c1c....
345 6FH6 - D8Q C9 H13 N3 O2 CN1C=C(C=C....
346 5MGG - 7MU C7 H7 Cl N2 O CNC(=O)c1c....
347 5ORB - JR6 C16 H19 N3 O2 S Cn1c(c2c(n....
348 4NRC ic50 = 241 uM 2LY C8 H9 N O3 S CNC(=O)c1c....
349 6FH7 - EN2 C17 H18 F N3 O3 CN1C=C(C=C....
350 5E9K - 5KX C3 H3 Cl N2 c1cnc([nH]....
351 4NRA Kd = 65 uM 2LW C13 H13 Cl N2 O CC(=O)N1CC....
352 5MGE Kd = 87 uM 7MX C9 H10 Cl N O3 CCOC(=O)C1....
353 4NR9 - ALY C8 H16 N2 O3 CC(=O)NCCC....
354 5E9L - 6AI C7 H7 N3 c1cc2cn[nH....
355 5OR9 ic50 = 88 uM JR5 C18 H21 F N4 O3 S Cn1c(c2c(n....
356 5E74 Kd = 39 uM 5KH C25 H19 F3 N2 O3 Cc1ccc(cc1....
357 5E9M - BAE C6 H13 N O CC(C)(C)C(....
358 6FGU - D9Q C13 H19 N3 O2 CN1C=C(C=C....
359 5DYX - ADE C5 H5 N5 c1[nH]c2c(....
360 5DYU - MZ0 C4 H6 N2 O c1c([nH]cn....
361 5E73 Kd = 23 uM UO1 C19 H18 N2 O3 Cc1ccc(cc1....
362 7K6R - 9ST C17 H21 Br N4 O CN1C[C@H](....
363 7KDW - WCV C20 H21 N5 O C#CCNc1ncc....
364 7KDZ - WCS C22 H30 N6 O3 S CN(C)CCCOc....
365 7K6S - VYM C13 H16 N2 O c1cc2c(cc1....
366 5A7C ic50 = 0.00018 M 5D4 C10 H20 N2 O2 CC(=O)NCCC....
367 5TPX Kd = 280 nM 7H7 C21 H24 N6 Cc1nnc2n1n....
368 6MO8 - JWD C19 H17 N3 O2 Cc1c(c(on1....
369 6ONY - HWV C28 H30 F N3 O4 CCNC(=O)c1....
370 6JKE - BUX C13 H6 Cl2 N2 O4 c1cc(cc(c1....
371 6MO7 - JWA C19 H25 N3 O4 S Cc1ccc(cc1....
372 6MO9 - JVY C19 H21 N3 O3 S Cc1c(c(on1....
373 3AQA - BYH C17 H16 N4 S2 CN1c2ccccc....
374 6K05 Ki = 95.5 nM CQF C22 H21 Cl N6 Cc1nnc2n1-....
375 5WUU ic50 = 0.81 uM 7UU C18 H18 N2 O3 S CN(CCCNC1=....
376 5N17 Kd = 4.8 uM 8FK C19 H18 N2 O3 S CN1c2ccc(c....
377 5N16 Kd = 5 uM 8FN C22 H15 N5 O2 S c1ccc2c(c1....
378 6VIZ Ki = 120 nM QYY C27 H29 N3 O5 S CCNC(=O)c1....
379 6VIW Ki = 21.6 nM QYV C24 H21 F2 N3 O5 S CCNC(=O)c1....
380 5XXH ic50 = 6.8 uM E0D C18 H20 N2 O4 CC(=O)c1cn....
381 5ML0 - P2L C11 H17 Cl N4 O CN1CCC[C@H....
382 5W0L ic50 = 1.1 nM 9UD C27 H32 F2 N6 O2 CC(=O)N1CC....
383 5W0F ic50 = 16 nM 9U7 C25 H30 N6 O2 CC(=O)N1CC....
384 5W0E ic50 = 0.94 nM 9U4 C27 H33 F2 N7 O2 CNC(=O)N1C....
385 5W0Q ic50 = 18 uM 9UG C12 H16 N2 O2 Cc1ccc2c(c....
386 5W0I ic50 = 1.4 nM 9UA C26 H30 F2 N6 O2 CC(=O)N1CC....
387 5VOM ic50 = 0.79 uM 9GY C24 H23 N3 O4 C[C@H]1CN(....
388 2RI7 - ALA ARG THR MLY GLN THR ALA ARG LYS n/a n/a
389 6J3O Kd = 2.4 uM B4L C13 H19 N5 O CN1CCC[C@H....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 2LY; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 2LY 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: 2LY; Similar ligands found: 1157
No: Ligand Similarity coefficient
1 92P 0.9911
2 C2Y 0.9871
3 4ME 0.9785
4 M4E 0.9752
5 8GK 0.9666
6 1QP 0.9655
7 ICO 0.9642
8 TSS 0.9630
9 5WY 0.9574
10 M6Z 0.9569
11 30G 0.9567
12 M2K 0.9565
13 28N 0.9564
14 5RN 0.9554
15 C9E 0.9550
16 CH9 0.9549
17 Q6T 0.9539
18 F12 0.9533
19 8ZE 0.9504
20 15N 0.9499
21 IAC 0.9498
22 Z5P 0.9497
23 QPR 0.9496
24 DNF 0.9492
25 0JD 0.9489
26 2FY 0.9482
27 KYA 0.9482
28 PDC 0.9478
29 PEY 0.9477
30 AKH 0.9476
31 SRO 0.9476
32 DRG 0.9476
33 6NT 0.9469
34 NID 0.9461
35 ZYR 0.9456
36 VXX 0.9456
37 1F1 0.9443
38 7ZE 0.9441
39 2HU 0.9439
40 KDV 0.9439
41 E1T 0.9437
42 NVU 0.9435
43 E7Z 0.9435
44 HA5 0.9434
45 LNR 0.9434
46 N8Y 0.9432
47 3IT 0.9432
48 8XL 0.9431
49 5RO 0.9426
50 INE 0.9426
51 2ZQ 0.9422
52 BPU 0.9420
53 BK9 0.9415
54 M5H 0.9415
55 PH2 0.9412
56 0HN 0.9411
57 5NI 0.9408
58 HQD 0.9401
59 2ZM 0.9401
60 42C 0.9398
61 J9T 0.9394
62 5NE 0.9394
63 4TU 0.9393
64 0HO 0.9387
65 BGC 0.9383
66 GZL 0.9383
67 9UL 0.9382
68 0F9 0.9377
69 APS 0.9373
70 JAW 0.9373
71 0FO 0.9373
72 3NY 0.9368
73 8HC 0.9365
74 4MU 0.9360
75 9FL 0.9360
76 OW7 0.9357
77 15L 0.9356
78 BDP 0.9356
79 N2I 0.9353
80 6BL 0.9352
81 7VS 0.9352
82 5VL 0.9352
83 CWS 0.9351
84 GO2 0.9350
85 ODO 0.9349
86 9R5 0.9349
87 GDE 0.9348
88 9CA 0.9348
89 EA1 0.9347
90 52C 0.9347
91 1A7 0.9345
92 LDR 0.9344
93 7NI 0.9344
94 64C 0.9344
95 KUF 0.9344
96 3A9 0.9342
97 FE DB1 0.9341
98 5OB 0.9341
99 GCU 0.9341
100 TTY 0.9339
101 GTQ 0.9337
102 92K 0.9336
103 0N7 0.9336
104 M0W 0.9334
105 7MX 0.9330
106 9ZE 0.9328
107 TSR 0.9326
108 6ME 0.9324
109 6NI 0.9319
110 4NC 0.9318
111 XAZ 0.9318
112 XHP 0.9317
113 6KT 0.9316
114 1IT 0.9315
115 9AP 0.9312
116 0FK 0.9311
117 B62 0.9310
118 069 0.9307
119 ABI 0.9306
120 PJW 0.9306
121 NNO 0.9305
122 PD2 0.9303
123 X8D 0.9302
124 G3F 0.9302
125 M0Q 0.9301
126 2FQ 0.9301
127 TTL 0.9301
128 54X 0.9300
129 NLA 0.9300
130 23J 0.9300
131 I3A 0.9296
132 UAN 0.9296
133 6VD 0.9296
134 INO 0.9296
135 GJP 0.9295
136 0LH 0.9292
137 SHA 0.9292
138 61M 0.9292
139 7ME 0.9290
140 DQU 0.9288
141 0P6 0.9287
142 DNA 0.9287
143 BZ3 0.9286
144 SKA 0.9286
145 MS9 0.9284
146 4KL 0.9283
147 JB8 0.9283
148 GCB 0.9283
149 URC 0.9283
150 MVN 0.9281
151 UFO 0.9280
152 MR1 0.9280
153 FLV 0.9279
154 39O 0.9279
155 MUA 0.9278
156 DNC 0.9276
157 091 0.9276
158 3PF 0.9274
159 5RG 0.9271
160 AZ9 0.9270
161 8TX 0.9264
162 2HC 0.9263
163 AA 0.9261
164 44W 0.9260
165 M1H 0.9259
166 F31 0.9259
167 FHB 0.9259
168 5QY 0.9259
169 RM1 0.9259
170 ONR 0.9258
171 THA 0.9258
172 OTW 0.9258
173 APZ 0.9256
174 68A 0.9256
175 MQB 0.9255
176 ARP 0.9254
177 DHB 0.9252
178 6CS 0.9252
179 8G0 0.9251
180 226 0.9251
181 B55 0.9251
182 GLC 0.9250
183 8S0 0.9248
184 GV9 0.9247
185 BPY 0.9247
186 BEA 0.9246
187 FA0 0.9246
188 LDP 0.9245
189 7MU 0.9244
190 MRW 0.9242
191 1HN 0.9241
192 D48 0.9241
193 RXA 0.9239
194 4A3 0.9237
195 173 0.9236
196 209 0.9236
197 7W1 0.9235
198 TOF 0.9233
199 VK3 0.9232
200 W81 0.9231
201 0XT 0.9229
202 JR2 0.9229
203 SKM 0.9228
204 2AL 0.9228
205 AY4 0.9227
206 12Q 0.9226
207 HLZ 0.9224
208 DHK 0.9224
209 CHB 0.9221
210 LZM 0.9220
211 JDN 0.9219
212 HNQ 0.9219
213 ANF 0.9219
214 DIN 0.9218
215 6TZ 0.9217
216 FBB 0.9217
217 5CU 0.9216
218 7HQ 0.9215
219 67Y 0.9215
220 MYJ 0.9214
221 54G 0.9213
222 IV2 0.9212
223 JG8 0.9212
224 8CM 0.9211
225 44V 0.9209
226 VNL 0.9208
227 8XQ 0.9208
228 42A 0.9208
229 M5K 0.9207
230 NQ 0.9207
231 NOJ 0.9207
232 8IG 0.9207
233 3Z8 0.9206
234 93K 0.9206
235 BHA 0.9206
236 2K8 0.9206
237 2EC 0.9205
238 KJU 0.9202
239 7FF 0.9201
240 G3E 0.9200
241 3HM 0.9198
242 2BG 0.9197
243 GCS 0.9196
244 3HA 0.9196
245 5XC 0.9196
246 F9Y 0.9196
247 HQT 0.9193
248 4AA 0.9193
249 27B 0.9193
250 5NS 0.9192
251 BCU 0.9191
252 A7W 0.9191
253 ALE 0.9191
254 MQN 0.9189
255 IOS 0.9188
256 4Z4 0.9186
257 K2T 0.9186
258 FOT 0.9185
259 8W9 0.9185
260 AJ2 0.9183
261 MHK 0.9182
262 PRZ 0.9182
263 75K 0.9182
264 0GZ 0.9181
265 8WT 0.9181
266 HLD 0.9180
267 GAL 0.9179
268 XQG 0.9179
269 SE2 0.9178
270 OW4 0.9173
271 4M0 0.9172
272 TYL 0.9172
273 GNM 0.9172
274 3F0 0.9169
275 2HQ 0.9168
276 2SX 0.9167
277 9FE 0.9167
278 FDR 0.9167
279 UNC 0.9167
280 H5B 0.9167
281 X0U 0.9167
282 DBJ 0.9166
283 CFF 0.9166
284 5M0 0.9165
285 ZME 0.9164
286 4JQ 0.9164
287 FUD 0.9163
288 BTY 0.9163
289 J9Q 0.9161
290 1P7 0.9160
291 37T 0.9159
292 DOB 0.9159
293 MEW 0.9157
294 DPZ 0.9157
295 2HO 0.9157
296 363 0.9157
297 BZ2 0.9155
298 EVA 0.9153
299 AZ8 0.9153
300 3MB 0.9153
301 DBH 0.9153
302 O2A 0.9150
303 TT4 0.9150
304 AIN 0.9148
305 AJV 0.9147
306 ZZZ 0.9147
307 261 0.9147
308 SLS 0.9146
309 IJZ 0.9146
310 ESP 0.9146
311 PXL 0.9146
312 PRF 0.9146
313 9TZ 0.9144
314 6DP 0.9144
315 PBA 0.9143
316 LL1 0.9143
317 PYQ 0.9142
318 4HC 0.9142
319 5JL 0.9142
320 0FN 0.9142
321 9MG 0.9141
322 790 0.9140
323 A29 0.9140
324 HQJ 0.9140
325 JTH 0.9140
326 CTL 0.9139
327 4CS 0.9139
328 6RQ 0.9139
329 7WR 0.9138
330 FP1 0.9138
331 2F6 0.9138
332 2D0 0.9138
333 HHR 0.9137
334 BQ2 0.9136
335 N1E 0.9136
336 M1E 0.9135
337 EYY 0.9133
338 AJY 0.9133
339 5NU 0.9133
340 3HB 0.9132
341 ESX 0.9131
342 57O 0.9131
343 AX3 0.9131
344 3DO 0.9130
345 NDH 0.9130
346 P9P 0.9130
347 Q24 0.9129
348 AQO 0.9129
349 JLZ 0.9129
350 ORO 0.9129
351 ESI 0.9129
352 OMD 0.9129
353 86J 0.9128
354 ICB 0.9128
355 TQU 0.9127
356 JXW 0.9126
357 5QX 0.9124
358 DIE 0.9124
359 R20 0.9124
360 5GU 0.9123
361 9KT 0.9123
362 KTJ 0.9123
363 ES5 0.9122
364 KT7 0.9121
365 ZZ8 0.9119
366 CLZ 0.9119
367 NTZ 0.9119
368 H33 0.9119
369 GTR 0.9118
370 67X 0.9118
371 53C 0.9118
372 DEW 0.9116
373 K3Q 0.9116
374 0TU 0.9116
375 94W 0.9115
376 KTW 0.9115
377 QMS 0.9113
378 E1P 0.9113
379 4RU 0.9112
380 1AL 0.9112
381 LT2 0.9111
382 TVP 0.9110
383 8WO 0.9110
384 4FS 0.9110
385 OVM 0.9109
386 6J9 0.9109
387 J5I 0.9107
388 XIY 0.9106
389 GVG 0.9106
390 I6G 0.9105
391 OVV 0.9105
392 NPA 0.9105
393 MT5 0.9104
394 JB5 0.9104
395 I59 0.9103
396 GAB 0.9102
397 03V 0.9101
398 QBM 0.9099
399 1M2 0.9098
400 2LP 0.9096
401 SAL 0.9095
402 TXW 0.9095
403 4HM 0.9095
404 3R6 0.9094
405 3OC 0.9094
406 LZ2 0.9093
407 KJH 0.9093
408 B60 0.9092
409 XFE 0.9092
410 GLO 0.9092
411 BE2 0.9091
412 3NT 0.9091
413 5B1 0.9090
414 OCH 0.9089
415 EWG 0.9089
416 15E 0.9088
417 2O6 0.9087
418 DHY 0.9087
419 FGZ 0.9086
420 SKF 0.9086
421 1WC 0.9086
422 PHE 0.9085
423 7CT 0.9084
424 BZJ 0.9084
425 LI6 0.9083
426 ET2 0.9083
427 EOL 0.9082
428 6FZ 0.9082
429 PE0 0.9081
430 L5V 0.9081
431 5MK 0.9080
432 H42 0.9080
433 DEE 0.9080
434 M3Q 0.9079
435 QSB 0.9078
436 2AQ 0.9078
437 8OZ 0.9077
438 AN3 0.9077
439 5V7 0.9076
440 TIY 0.9076
441 MAJ 0.9076
442 CFA 0.9076
443 CKA 0.9075
444 COU 0.9075
445 R9Y 0.9074
446 8NX 0.9074
447 MSR 0.9073
448 9TW 0.9069
449 4SX 0.9069
450 YSO 0.9067
451 4YO 0.9065
452 QSH 0.9064
453 4I8 0.9064
454 BB4 0.9063
455 CWJ 0.9063
456 3J8 0.9061
457 L22 0.9061
458 20J 0.9057
459 5JQ 0.9055
460 OVP 0.9054
461 JKE 0.9054
462 IOP 0.9053
463 344 0.9051
464 HBO 0.9050
465 X0V 0.9050
466 ASC 0.9049
467 8GC 0.9049
468 A7H 0.9048
469 M5N 0.9047
470 2KA 0.9046
471 3AB 0.9045
472 TRP 0.9045
473 SAF 0.9045
474 HHS 0.9044
475 ES2 0.9044
476 EN1 0.9043
477 LGC 0.9042
478 OXC 0.9042
479 5OF 0.9042
480 2AK 0.9041
481 HJP 0.9041
482 VM1 0.9041
483 7B3 0.9040
484 C2U 0.9040
485 IHB 0.9040
486 ADA 0.9040
487 DIU 0.9040
488 ANC 0.9040
489 5TY 0.9040
490 NFM 0.9039
491 EKZ 0.9037
492 REL 0.9037
493 DX3 0.9036
494 22L 0.9036
495 PNZ 0.9036
496 VYM 0.9035
497 OA3 0.9035
498 9BF 0.9035
499 6QF 0.9035
500 5VJ 0.9034
501 8MO 0.9033
502 45L 0.9030
503 EYK 0.9030
504 PFL 0.9030
505 7I2 0.9029
506 VGD 0.9029
507 EMZ 0.9026
508 G5V 0.9024
509 NAG 0.9023
510 DTR 0.9022
511 3AL 0.9022
512 3M0 0.9021
513 4SV 0.9020
514 VNJ 0.9020
515 SX1 0.9019
516 HHA 0.9019
517 PQ0 0.9019
518 Q02 0.9019
519 LYL 0.9018
520 PIM 0.9018
521 JA8 0.9017
522 D07 0.9015
523 GYE 0.9015
524 5WX 0.9014
525 1VK 0.9014
526 SHG 0.9012
527 JYT 0.9012
528 JBK 0.9012
529 H7Y 0.9012
530 4M4 0.9012
531 EV0 0.9012
532 IPB 0.9011
533 S8D 0.9010
534 JP2 0.9009
535 OGA 0.9008
536 XX2 0.9007
537 1L5 0.9007
538 XQ0 0.9006
539 D1X 0.9006
540 DOR 0.9005
541 5WV 0.9004
542 F4E 0.9003
543 MAQ 0.9002
544 I2E 0.9002
545 60Q 0.9000
546 ALL 0.9000
547 P7Y 0.9000
548 1P8 0.9000
549 36R 0.9000
550 AEH 0.8999
551 MNP 0.8997
552 9KH 0.8997
553 FXH 0.8996
554 SJ5 0.8996
555 ABV 0.8996
556 N91 0.8995
557 S0E 0.8994
558 5WU 0.8993
559 5HN 0.8993
560 EGR 0.8992
561 EUG 0.8991
562 XEN 0.8991
563 CTS 0.8990
564 DRL 0.8990
565 N7I 0.8990
566 JXK 0.8989
567 TIU 0.8989
568 PIY 0.8989
569 HH8 0.8988
570 3R4 0.8988
571 TYE 0.8987
572 ROI 0.8987
573 V55 0.8986
574 V1T 0.8986
575 3TC 0.8986
576 BZE 0.8986
577 L99 0.8985
578 Q71 0.8985
579 495 0.8984
580 ES6 0.8984
581 1KP 0.8983
582 GCW 0.8983
583 G12 0.8983
584 OTD 0.8983
585 4JT 0.8983
586 KP6 0.8983
587 CLW 0.8982
588 WCE 0.8981
589 KMY 0.8981
590 AMR 0.8980
591 GOX 0.8979
592 49O 0.8979
593 6XI 0.8979
594 TGX 0.8978
595 CWM 0.8978
596 GC2 0.8978
597 QX2 0.8977
598 BSX 0.8977
599 4V2 0.8976
600 FBG 0.8974
601 32X 0.8974
602 KKN 0.8973
603 IWT 0.8973
604 JU2 0.8973
605 LKA 0.8973
606 GLT 0.8972
607 DHQ 0.8972
608 1X7 0.8971
609 HC4 0.8971
610 M78 0.8971
611 GJZ 0.8970
612 SNU 0.8970
613 3MG 0.8969
614 55D 0.8969
615 FB1 0.8968
616 N3W 0.8966
617 97T 0.8966
618 4P5 0.8966
619 BHO 0.8966
620 3VX 0.8966
621 FIX 0.8965
622 F69 0.8964
623 34D 0.8964
624 E5X 0.8964
625 AOS 0.8963
626 DHC 0.8961
627 NCD 0.8961
628 3U4 0.8961
629 0BP 0.8961
630 PHU 0.8960
631 AP4 0.8958
632 KBB 0.8956
633 M1A 0.8956
634 ES7 0.8955
635 293 0.8954
636 SYV 0.8953
637 6M4 0.8953
638 I1E 0.8953
639 EYV 0.8952
640 4XV 0.8952
641 ISN 0.8952
642 CIT 0.8952
643 NGW 0.8951
644 NGT 0.8951
645 SOR 0.8951
646 NMJ 0.8951
647 Q88 0.8950
648 0W1 0.8950
649 QBK 0.8949
650 HDH 0.8948
651 MZB 0.8948
652 6R8 0.8946
653 PFB 0.8946
654 HHH 0.8946
655 BA5 0.8945
656 7WV 0.8945
657 JXZ 0.8945
658 TEP 0.8944
659 LEL 0.8944
660 RD4 0.8942
661 67N 0.8942
662 NIZ 0.8942
663 TPA 0.8942
664 FA3 0.8942
665 HIS 0.8940
666 TYR 0.8938
667 B57 0.8937
668 4VS 0.8936
669 CCV 0.8935
670 3BU 0.8935
671 ISZ 0.8935
672 B5D 0.8935
673 6M9 0.8934
674 BRT 0.8934
675 692 0.8934
676 1SQ 0.8933
677 ZON 0.8932
678 CFI 0.8932
679 2H5 0.8931
680 ANN 0.8931
681 PZI 0.8931
682 9DG 0.8928
683 K5W 0.8928
684 KGK 0.8927
685 JXN 0.8926
686 3QV 0.8926
687 NGO 0.8925
688 I3E 0.8924
689 GCO 0.8923
690 A5E 0.8923
691 KBG 0.8922
692 UNJ 0.8922
693 64E 0.8921
694 PHH 0.8920
695 5F5 0.8920
696 24W 0.8920
697 L7T 0.8919
698 X05 0.8918
699 AHR 0.8918
700 SBK 0.8917
701 1NP 0.8916
702 4WL 0.8916
703 R8V 0.8915
704 3DM 0.8915
705 OTR 0.8915
706 TWO 0.8914
707 9PY 0.8914
708 KOJ 0.8913
709 FDB 0.8912
710 B2J 0.8912
711 AH8 0.8911
712 JUG 0.8911
713 KTA 0.8911
714 4AV 0.8910
715 AW5 0.8910
716 XAN 0.8910
717 UFV 0.8909
718 1LQ 0.8909
719 2GQ 0.8909
720 SYA 0.8908
721 PQK 0.8907
722 K97 0.8907
723 RAT 0.8906
724 DPT 0.8906
725 3BZ 0.8905
726 3WA 0.8905
727 4XH 0.8904
728 4FH 0.8904
729 SR1 0.8904
730 HJH 0.8903
731 JFJ 0.8903
732 149 0.8903
733 G1O 0.8902
734 JF1 0.8902
735 PX7 0.8900
736 DBX 0.8900
737 KF5 0.8900
738 DMD 0.8900
739 NBG 0.8900
740 505 0.8899
741 0W8 0.8899
742 CN0 0.8898
743 TAG 0.8897
744 X09 0.8896
745 H4E 0.8896
746 MD6 0.8896
747 CX4 0.8895
748 ES0 0.8895
749 GUN 0.8894
750 YH7 0.8894
751 PHB 0.8894
752 0FR 0.8892
753 EXD 0.8891
754 YPN 0.8890
755 HBD 0.8890
756 MT0 0.8889
757 9UG 0.8889
758 DE5 0.8889
759 2JK 0.8888
760 GF4 0.8888
761 NQH 0.8888
762 6AP 0.8887
763 878 0.8887
764 XYL 0.8885
765 EYA 0.8884
766 BNL 0.8883
767 46P 0.8882
768 PH3 0.8882
769 AC2 0.8880
770 KIB 0.8879
771 IFP 0.8878
772 MO8 0.8877
773 ES1 0.8877
774 NPO 0.8877
775 12T 0.8876
776 PAC 0.8875
777 NCT 0.8875
778 R2P 0.8875
779 ZB1 0.8874
780 KJY 0.8874
781 B56 0.8874
782 KFH 0.8874
783 FHC 0.8874
784 6M1 0.8873
785 DHR 0.8873
786 F05 0.8872
787 SR4 0.8871
788 AZA 0.8871
789 6X9 0.8870
790 4XS 0.8869
791 GNL 0.8868
792 NSG 0.8868
793 MWP 0.8868
794 GRE 0.8868
795 463 0.8868
796 1Z6 0.8868
797 141 0.8867
798 EV3 0.8866
799 GOG 0.8866
800 535 0.8865
801 JKZ 0.8865
802 7W4 0.8865
803 CKU 0.8864
804 3FH 0.8863
805 GZ2 0.8862
806 ICT 0.8861
807 ASO 0.8861
808 M5E 0.8861
809 1XM 0.8861
810 WOO 0.8860
811 8WZ 0.8859
812 826 0.8858
813 B4O 0.8858
814 2D3 0.8857
815 SOE 0.8856
816 MPK 0.8855
817 G6D 0.8855
818 XQK 0.8854
819 36M 0.8853
820 FBV 0.8853
821 K82 0.8853
822 BZX 0.8852
823 FWD 0.8851
824 N5J 0.8851
825 XDK 0.8851
826 HKD 0.8851
827 3RI 0.8850
828 CR1 0.8849
829 2FG 0.8848
830 3ID 0.8846
831 IBM 0.8845
832 HZQ 0.8844
833 JRB 0.8844
834 HA7 0.8843
835 JF2 0.8843
836 A2F 0.8843
837 PAB 0.8843
838 MT8 0.8842
839 HQY 0.8840
840 3HP 0.8840
841 CXH 0.8840
842 28S 0.8839
843 IGA 0.8839
844 AC6 0.8838
845 PBZ 0.8838
846 JBQ 0.8837
847 4VY 0.8837
848 G2F 0.8836
849 FF2 0.8836
850 12B 0.8834
851 BOA 0.8834
852 1Y6 0.8834
853 OHP 0.8834
854 774 0.8833
855 5SG 0.8833
856 ZXD 0.8832
857 LAO 0.8832
858 268 0.8831
859 EVF 0.8831
860 K22 0.8829
861 CSN 0.8829
862 E35 0.8828
863 0RW 0.8828
864 1WD 0.8828
865 H4B 0.8828
866 SVN 0.8826
867 DQA 0.8826
868 X0W 0.8825
869 4MA 0.8824
870 82I 0.8823
871 NDM 0.8823
872 NOY 0.8822
873 IFL 0.8822
874 96R 0.8820
875 F06 0.8818
876 HPT 0.8818
877 DK1 0.8817
878 JPZ 0.8817
879 FYU 0.8817
880 258 0.8816
881 SVD 0.8815
882 PO6 0.8815
883 3SK 0.8815
884 4YS 0.8813
885 1GN 0.8813
886 25W 0.8813
887 SXS 0.8812
888 39U 0.8812
889 5WN 0.8811
890 X11 0.8810
891 A13 0.8810
892 RB5 0.8809
893 1LM 0.8809
894 XDE 0.8809
895 7B4 0.8809
896 HDL 0.8808
897 ADZ 0.8808
898 S24 0.8807
899 O72 0.8807
900 MB1 0.8806
901 LPK 0.8806
902 F2W 0.8806
903 F9P 0.8806
904 5IQ 0.8805
905 537 0.8805
906 KG1 0.8805
907 AZG 0.8804
908 FBM 0.8803
909 AEF 0.8803
910 GLA 0.8802
911 SYR 0.8800
912 UEG 0.8799
913 MIG 0.8798
914 3Y7 0.8797
915 MBG 0.8797
916 LTT 0.8797
917 5Q0 0.8795
918 GXY 0.8794
919 QWN 0.8793
920 CWD 0.8790
921 6F0 0.8789
922 RVE 0.8788
923 F0J 0.8788
924 QIC 0.8788
925 QWW 0.8787
926 XX3 0.8786
927 GCV 0.8786
928 DX4 0.8785
929 0CU 0.8784
930 9LI 0.8784
931 FBW 0.8783
932 1U6 0.8782
933 329 0.8781
934 E1K 0.8779
935 QXW 0.8777
936 Q7A 0.8775
937 TBS 0.8772
938 N0Z 0.8771
939 4ZA 0.8771
940 2A9 0.8770
941 HQ9 0.8769
942 5XB 0.8766
943 FEH 0.8766
944 4AN 0.8765
945 290 0.8764
946 CFP 0.8763
947 5GT 0.8763
948 GT0 0.8761
949 FK8 0.8760
950 MYI 0.8759
951 3GQ 0.8759
952 SWA 0.8759
953 8NB 0.8759
954 BDI 0.8758
955 PXM 0.8758
956 PQZ 0.8757
957 KLK 0.8756
958 8VN 0.8755
959 AMQ 0.8753
960 3IL 0.8750
961 FBU 0.8750
962 5JT 0.8748
963 680 0.8748
964 II6 0.8746
965 M1Z 0.8745
966 PBN 0.8744
967 NTM 0.8742
968 7ZL 0.8741
969 ZVO 0.8741
970 MXD 0.8741
971 EPR 0.8740
972 SYE 0.8740
973 PHT 0.8740
974 23A 0.8738
975 K17 0.8738
976 7MW 0.8737
977 G4D 0.8737
978 II4 0.8736
979 L21 0.8736
980 CBF 0.8735
981 D3G 0.8735
982 GJS 0.8733
983 BWD 0.8731
984 5TZ 0.8731
985 B53 0.8731
986