Receptor
PDB id Resolution Class Description Source Keywords
5C1W 1.7 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 4,6-DICHLORO-2-CYCLOPROPYL-5-METHYL-PYR HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG B:802;
A:802;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
ZN B:801;
A:801;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
4XS A:803;
Valid;
none;
Ki = 8.7 uM
203.069 C8 H8 Cl2 N2 Cc1c(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C2H 2.09 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 6-CHLORO-N-[(2,4-DIMETHYLTHIAZOL-5-YL)M METHYL-2-[3-(2-QUINOLYL)PROPOXY]PYRIMIDIN-4-AMINE HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Members (67)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
70% Homology Family (77)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
68 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
69 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
70 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
71 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
72 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
73 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
74 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
75 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
76 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
77 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
50% Homology Family (230)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 2CHM ic50 = 5.5 nM 3P4 C23 H29 N6 O3 CCc1c2c([n....
2 3TGG - 0H3 C23 H31 N5 O4 CCCOCCN1c2....
3 3HDZ ic50 = 51 nM PD6 C18 H19 N3 O CCCCN1C=CC....
4 3TGE ic50 = 0.07 nM TGE C24 H32 N6 O4 CCCOCCN1c2....
5 3B2R - VDN C23 H32 N6 O4 S CCCc1nc(c2....
6 2H44 ic50 = 1.7 uM 7CA C27 H32 O10 C[C@H]1[C@....
7 2H42 ic50 = 2.4 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
8 1T9S - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
9 4MD6 ic50 = 17 nM 24E C22 H15 N O3 S c1ccc2c(c1....
10 1UHO Kd ~ 0.6 nM VDN C23 H32 N6 O4 S CCCc1nc(c2....
11 1UDT Kd ~ 0.5 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
12 1RKP - IBM C10 H14 N4 O2 CC(C)CN1c2....
13 4IA0 ic50 = 77 nM 5BB C25 H37 Br N4 O4 S CCCCCCCCC1....
14 3SIE ic50 = 13.3 nM 5BO C20 H27 Br N4 O4 S CCCOc1ccc(....
15 3HC8 ic50 = 2.9 nM PD4 C24 H32 N6 O4 CCCOCCN1c2....
16 1XP0 ic50 = 0.001 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
17 1XOZ ic50 = 0.0012 uM CIA C22 H19 N3 O4 CN1CC(=O)N....
18 6L6E - E6L C23 H26 Cl N7 O3 COc1ccc(cc....
19 4I9Z ic50 = 18.2 nM 5BA C23 H31 Br N4 O3 CCCOc1ccc(....
20 1TBF - VIA C22 H30 N6 O4 S CCCc1c2c(n....
21 4OEX Kd = 0.000000064 M 5EO C20 H28 N4 O4 S CCCOc1ccc(....
22 4G2Y ic50 > 1000 nM NI5 C21 H28 N4 O4 S CCCOc1ccc(....
23 4OEW Kd = 0.000000064 M 5IO C20 H27 I N4 O4 S CCCOc1ccc(....
24 1Y2B ic50 = 82 uM DEE C8 H12 N2 O2 CCOC(=O)c1....
25 6IMD ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
26 1TBB - ROL C16 H21 N O3 COc1ccc(cc....
27 4W1O - 3GJ C19 H17 Cl2 N3 O4 CCc1cc(on1....
28 5LBO - 6M5 C33 H40 N6 O4 COc1ccc(cc....
29 6IMT ic50 = 0.25 uM AK0 C22 H23 F N2 O3 COc1cc2c(c....
30 6RCW - JX2 C30 H33 N3 O4 COc1ccc(cc....
31 6HWO Ki = 0.00000079 M FFZ C28 H29 N3 O3 CC(C)N1C(=....
32 6IMI ic50 = 26.1 uM AH6 C13 H17 N O3 CCOc1cc2c(....
33 6IMB ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
34 1ZKN - IBM C10 H14 N4 O2 CC(C)CN1c2....
35 6NJJ - KR7 C21 H15 Cl F3 N O2 c1cc(cc(c1....
36 3SL4 ic50 = 0.027 uM JN4 C21 H21 N3 O4 S C=CNC(=O)N....
37 1XOQ ic50 = 0.68 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
38 1Y2E ic50 = 0.16 uM 5DE C14 H17 N3 O2 CCOC(=O)c1....
39 1PTW - AMP C10 H14 N5 O7 P c1nc(c2c(n....
40 6FTW - E6Z C25 H29 N3 O3 COc1ccc(cc....
41 5WQA ic50 = 0.011 uM J20 C36 H26 O5 COc1ccc(cc....
42 1Y2D ic50 = 2 uM 4DE C15 H18 N2 O3 CCOC(=O)c1....
43 6F8W ic50 = 23 uM D0E C22 H29 N3 O4 COc1ccc(cc....
44 6AKR - A0O C15 H16 O3 CC(=CCc1c(....
45 1XON ic50 = 0.021 nM PIL C18 H18 Cl2 N2 O3 COc1ccc(cc....
46 6NJH - KRD C19 H18 Cl N5 O CCc1nc(nc(....
47 1TB7 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
48 6FDC ic50 = 2.3 uM DD5 C22 H29 F2 N3 O4 c1cc(c(cc1....
49 6IND ic50 = 0.24 uM AKO C23 H26 N2 O3 Cc1ccc2c(c....
50 6INK ic50 = 0.27 uM AKU C22 H24 N2 O3 COc1cc2c(c....
51 6IMR ic50 = 4.3 uM AJX C23 H26 N2 O3 COc1cc2c(c....
52 1XOR ic50 = 0.39 uM ZAR C12 H10 F2 N2 O3 COc1cc(ccc....
53 3G4K ic50 = 288 nM ROL C16 H21 N O3 COc1ccc(cc....
54 1Y2C ic50 = 0.27 uM 3DE C14 H17 N2 O2 CCOC(=O)c1....
55 2FM0 ic50 = 0.4 nM M98 C23 H18 F8 N2 O4 S c1cc(c[n+]....
56 6KJZ ic50 = 420 nM MKU C24 H26 O6 CC(=CCc1c2....
57 6F8T ic50 = 7 uM CZT C22 H34 N2 O5 C[C@@H]1CN....
58 1Y2K ic50 = 0.021 uM 7DE C14 H15 N3 O4 CCOC(=O)c1....
59 1XOM ic50 = 0.011 uM CIO C20 H25 N O4 COc1ccc(cc....
60 6KK0 ic50 = 17 nM M36 C31 H36 O8 CC(=CCc1c2....
61 2PW3 - CMP C10 H12 N5 O6 P c1nc(c2c(n....
62 6IM6 ic50 = 20.7 uM AH3 C13 H17 N O3 CCOc1cc2c(....
63 1Q9M ic50 = 0.33 uM ROL C16 H21 N O3 COc1ccc(cc....
64 4WCU ic50 = 3 nM 3KQ C24 H22 Cl2 N2 O5 COc1ccc(c(....
65 6F8U ic50 = 0.8 uM CZQ C21 H28 F2 N2 O5 C[C@@H]1CN....
66 6INM ic50 = 0.51 uM AKU C22 H24 N2 O3 COc1cc2c(c....
67 2FM5 ic50 = 43 nM M99 C23 H18 F8 N2 O4 S c1cc(c[n+]....
68 3G4I - D71 C19 H13 N5 O4 c1cc(cc(c1....
69 6F6U ic50 = 16 uM CV8 C21 H30 N2 O5 C[C@@H]1CN....
70 6F8V ic50 = 16 uM D0B C24 H33 N3 O4 C[C@@H]1CN....
71 6IMO ic50 = 0.65 uM AJL C21 H22 N2 O3 COc1cc2c(c....
72 3G4L ic50 = 5.8 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
73 4G2J ic50 = 11 nM 0WF C21 H25 N5 O2 C[C@H](C1=....
74 3K3H - BYE C15 H12 Cl F3 N4 O C[C@@H](CC....
75 3DY8 - IBM C10 H14 N4 O2 CC(C)CN1c2....
76 3DYN - PCG C10 H12 N5 O7 P c1nc2c(n1[....
77 3DYQ - PCG C10 H12 N5 O7 P c1nc2c(n1[....
78 3JSW ic50 = 66 nM JAR C20 H25 N5 O C[C@@H]1C[....
79 3DYS - IBM C10 H14 N4 O2 CC(C)CN1c2....
80 4E90 ic50 = 8 nM 7RG C20 H25 N7 O2 C[C@@H]1C[....
81 5U7K ic50 = 7.1 nM 7Y1 C20 H22 N6 O CCCOc1cncc....
82 6CYD ic50 = 2 nM FKG C16 H15 F3 N4 O2 CC1=Nc2c(c....
83 5TZA ic50 = 0.001 uM 7OG C22 H21 N5 O Cc1cc(n2c(....
84 6C7G ic50 = 18.2 nM EOY C31 H34 Cl N5 O2 Cc1c2nnc(n....
85 5VP0 ic50 = 0.61 nM 9GJ C19 H18 F4 N4 O5 COC[C@H](c....
86 5U00 ic50 = 0.002 uM 7OV C18 H15 F3 I N5 O Cc1cc(n2c(....
87 5U7I ic50 = 66.6 nM 7XS C20 H25 N5 O2 CC(C)Cc1c2....
88 5U7J ic50 = 389.6 nM 7XV C18 H22 N4 O2 CC(C)Cc1nn....
89 5XKM ic50 = 24 nM 87R C18 H17 F3 N4 O2 CC[C@H](c1....
90 6B98 Ki = 22.4 uM D07 C7 H8 Cl N5 CNc1c2cnn(....
91 6B96 Ki = 14.3 nM CZV C15 H11 Cl F3 N5 c1cc(ccc1C....
92 5U7D ic50 = 0.5 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
93 6ZQZ ic50 = 24 nM QOQ C18 H19 Cl F2 N6 Cc1cc(cc(n....
94 5TZX ic50 = 0.052 uM 7OY C18 H15 Cl F3 N5 O Cc1cc(n2c(....
95 6C7I ic50 = 0.38 nM EP7 C22 H22 Cl N5 O2 Cc1c2nnc(n....
96 6CYB ic50 = 0.96 nM FKV C16 H12 F6 N4 O2 C[C@@H](c1....
97 6B97 Ki = 0.237 uM CZY C15 H13 Cl F3 N5 C[C@H](c1c....
98 5TZZ ic50 = 0.014 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
99 5VP1 ic50 = 0.51 nM 9GA C22 H22 F3 N7 O3 Cc1cn2c(c(....
100 4HTX ic50 = 4.7 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
101 6EZF - C6Z C11 H8 Cl2 N2 S c1cc(c(cc1....
102 5TZ3 ic50 = 0.14 uM 7OM C22 H22 N6 O Cc1cc(n2c(....
103 5TZH ic50 = 0.679 uM 7OP C18 H16 F3 N5 O Cc1cc(n2c(....
104 6ZND ic50 = 66 nM QMZ C20 H23 N5 O4 COc1cc(cc(....
105 5TZC ic50 = 0.008 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
106 3ITU ic50 = 40 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
107 6C7F ic50 = 0.00000001 M EOS C22 H22 Cl N5 O2 Cc1c2nnc(n....
108 6C7E ic50 = 0.24 nM EOG C18 H14 Cl N5 O Cc1c2nnc(n....
109 6C7J ic50 = 1.32 nM EPV C25 H28 Cl N5 O2 Cc1c2nnc(n....
110 4JIB ic50 = 45 nM 1L6 C23 H28 N6 O2 CCC(C)(C)c....
111 5U7L ic50 = 4.9 nM 7Y4 C24 H30 N8 CCc1ccc(cc....
112 4D09 ic50 = 1.7 nM 788 C24 H19 N5 O Cc1c2nnc(n....
113 6C7D ic50 = 0.17 nM EOJ C27 H26 Cl N5 O Cc1c2nnc(n....
114 5TZW ic50 = 0.987 uM 7P4 C18 H15 F4 N5 O Cc1cc(n2c(....
115 6CYC ic50 = 14 nM FKJ C15 H13 F3 N4 O3 C[C@@H](c1....
116 4D08 ic50 = 10 nM Q2T C24 H28 N6 O2 CCCCOc1cc(....
117 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
118 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
119 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
120 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
121 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
122 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
123 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
124 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
125 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
126 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
127 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
128 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
129 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
130 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
131 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
132 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
133 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
134 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
135 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
136 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
137 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
138 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
139 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
140 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
141 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
142 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
143 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
144 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
145 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
146 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
147 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
148 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
149 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
150 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
151 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
152 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
153 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
154 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
155 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
156 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
157 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
158 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
159 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
160 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
161 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
162 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
163 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
164 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
165 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
166 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
167 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
168 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
169 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
170 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
171 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
172 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
173 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
174 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
175 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
176 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
177 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
178 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
179 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
180 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
181 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
182 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
183 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
184 5LAQ Ki = 0.63 nM 6M5 C33 H40 N6 O4 COc1ccc(cc....
185 3SHZ ic50 = 35.9 nM 5CO C20 H27 Cl N4 O4 S CCCOc1ccc(....
186 4G2W ic50 = 1.6 nM NI0 C22 H32 N4 O4 S CCCOc1ccc(....
187 3QI4 ic50 = 117.2 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
188 4QGE Ki = 0.5 nM 35O C20 H24 N6 O3 C[C@H](C(=....
189 3QI3 - PDB C15 H12 Cl F3 N4 O C[C@H](CC1....
190 4Y86 ic50 = 58 nM 49E C18 H20 Cl N5 O CC(c1ccc(c....
191 3ECN ic50 = 698 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
192 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
193 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
194 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
195 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
196 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
197 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
198 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
199 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
200 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
201 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
202 2QYK ic50 = 3.3 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
203 3GWT ic50 = 7.94 pM 066 C27 H26 N4 O5 S Cc1cc(cc2c....
204 3WD9 ic50 = 8.3 nM QPC C24 H27 N5 O2 CC(C)(C)CN....
205 4KP6 ic50 = 0.87 nM 1S1 C12 H17 N9 CCC(CC)(C#....
206 4NW7 ic50 = 237 nM 2O5 C20 H17 Cl N4 O2 c1cc(cc(c1....
207 3FRG ic50 = 3.98 nM SK4 C18 H17 N3 O4 S COc1cccc(c....
208 1RO9 - 8BR C10 H13 Br N5 O7 P c1nc(c2c(n....
209 1XOT ic50 = 3.8 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
210 1XLX ic50 = 0.025 uM CIO C20 H25 N O4 COc1ccc(cc....
211 3O57 ic50 = 79.4 pM ZG2 C29 H34 N6 O3 CCn1c2c(cn....
212 3HMV - HBT C17 H17 N3 O4 S C[C@H]1CCc....
213 3O56 ic50 = 794 pM ZG1 C21 H27 N7 O3 CCn1c2c(cn....
214 1XLZ ic50 = 0.96 uM FIL C15 H20 N2 O4 C/C(=NOC(=....
215 1XN0 ic50 = 0.57 uM ROL C16 H21 N O3 COc1ccc(cc....
216 1TB5 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
217 3D3P ic50 = 3.1 nM 20A C21 H25 N5 O2 CCn1c2c(cn....
218 3W5E ic50 = 11 nM NVW C25 H28 N4 O3 S CC(C)(C)NC....
219 4MYQ ic50 = 32 nM 19T C19 H18 Cl N3 O2 S CCc1c(nc(n....
220 2QYL ic50 = 0.65 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
221 1XOS ic50 = 20 uM VIA C22 H30 N6 O4 S CCCc1c2c(n....
222 1XM6 ic50 = 0.42 uM 5RM C14 H19 N O4 CCCOc1cc(c....
223 1RO6 Ki ~ 375 nM ROL C16 H21 N O3 COc1ccc(cc....
224 1Y2H ic50 = 0.056 uM 6DE C14 H15 Cl N2 O2 CCOC(=O)c1....
225 1ROR - AMP C10 H14 N5 O7 P c1nc(c2c(n....
226 5UOY ic50 = 0.027 uM 8HM C24 H27 N5 O3 S COc1ccc(cc....
227 5W6E ic50 = 9.1 nM 0NY C17 H21 N5 O2 Cc1cc([nH]....
228 5B25 Ki = 0.058 nM 4QJ C29 H26 F N7 O CN1C(=O)c2....
229 5UP0 ic50 = 0.46 uM 8HP C18 H15 Cl N4 O S c1cc(ccc1C....
230 3G4G ic50 = 19 nM D71 C19 H13 N5 O4 c1cc(cc(c1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 4XS; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 4XS 1 1
2 4XV 0.588235 0.852941
3 4XY 0.47619 0.674419
Similar Ligands (3D)
Ligand no: 1; Ligand: 4XS; Similar ligands found: 1185
No: Ligand Similarity coefficient
1 QSH 0.9778
2 GDE 0.9753
3 G3F 0.9729
4 BGC 0.9728
5 GCS 0.9728
6 FGZ 0.9702
7 DHK 0.9656
8 UFV 0.9646
9 8S0 0.9623
10 7WR 0.9579
11 GTR 0.9556
12 GLC 0.9540
13 EVA 0.9538
14 DHB 0.9489
15 CHB 0.9482
16 3MG 0.9480
17 GAL 0.9479
18 4FH 0.9478
19 IHB 0.9473
20 15L 0.9466
21 BDP 0.9459
22 QSB 0.9456
23 JTH 0.9448
24 GCB 0.9441
25 P9P 0.9429
26 4NC 0.9422
27 X0V 0.9419
28 INO 0.9418
29 JLZ 0.9417
30 LGC 0.9414
31 93K 0.9407
32 2FG 0.9400
33 149 0.9399
34 NOJ 0.9399
35 9TW 0.9388
36 2H5 0.9387
37 1GN 0.9386
38 34D 0.9382
39 DQA 0.9380
40 2HO 0.9377
41 MBG 0.9376
42 V55 0.9370
43 DOR 0.9369
44 GIV 0.9368
45 T6C 0.9367
46 MYJ 0.9366
47 AS3 0.9362
48 42J 0.9361
49 4XR 0.9360
50 HX3 0.9355
51 XX2 0.9355
52 GCU 0.9354
53 GLA 0.9352
54 S76 0.9349
55 ORO 0.9339
56 SKM 0.9339
57 D1X 0.9338
58 SYA 0.9335
59 FA3 0.9333
60 KOJ 0.9330
61 4M4 0.9329
62 EUG 0.9329
63 LDP 0.9328
64 F0J 0.9327
65 NNO 0.9327
66 AHR 0.9321
67 FHB 0.9320
68 YIO 0.9320
69 4SX 0.9319
70 2D0 0.9317
71 IV2 0.9313
72 DHY 0.9310
73 4A3 0.9309
74 VNL 0.9309
75 OXC 0.9308
76 AW5 0.9306
77 EKZ 0.9303
78 ADA 0.9293
79 OMD 0.9291
80 IFP 0.9288
81 2A7 0.9288
82 Q88 0.9288
83 2LP 0.9287
84 SHG 0.9286
85 URC 0.9286
86 EMZ 0.9281
87 FP1 0.9281
88 3HM 0.9280
89 261 0.9277
90 F31 0.9268
91 G4D 0.9265
92 TBP 0.9265
93 AX3 0.9263
94 2AL 0.9263
95 4AA 0.9261
96 ZZ3 0.9260
97 8WO 0.9254
98 UFO 0.9252
99 EOL 0.9252
100 UAN 0.9248
101 MJ2 0.9246
102 CWM 0.9243
103 ES0 0.9243
104 7MH 0.9242
105 X6X 0.9239
106 LNR 0.9239
107 A7W 0.9235
108 EXD 0.9234
109 2A9 0.9230
110 DEE 0.9229
111 8W9 0.9227
112 GLT 0.9224
113 APZ 0.9224
114 6OT 0.9218
115 EV0 0.9216
116 QWW 0.9212
117 QX2 0.9211
118 DNC 0.9209
119 KBG 0.9206
120 23J 0.9205
121 L99 0.9203
122 57O 0.9203
123 A13 0.9202
124 PRZ 0.9198
125 K3Q 0.9198
126 DHS 0.9192
127 ZXD 0.9192
128 BNT 0.9192
129 AEH 0.9186
130 HQD 0.9184
131 JFJ 0.9183
132 8WT 0.9180
133 QPR 0.9178
134 3XX 0.9173
135 LKA 0.9170
136 DGJ 0.9169
137 FBU 0.9168
138 AEF 0.9166
139 35C 0.9164
140 AZ9 0.9164
141 KTA 0.9158
142 PHB 0.9158
143 C2U 0.9154
144 4HM 0.9153
145 3NT 0.9152
146 IAC 0.9151
147 0HO 0.9149
148 CN0 0.9148
149 G2F 0.9148
150 4CS 0.9145
151 PFB 0.9143
152 4FA 0.9143
153 QIC 0.9142
154 KT7 0.9141
155 ASC 0.9139
156 0F9 0.9139
157 N3W 0.9139
158 53C 0.9137
159 0N7 0.9136
160 NPO 0.9133
161 TSS 0.9133
162 FA6 0.9132
163 G6D 0.9132
164 3C4 0.9130
165 VOH 0.9129
166 SOR 0.9127
167 OVV 0.9127
168 TWO 0.9126
169 HBA 0.9124
170 LYL 0.9122
171 SYR 0.9122
172 CWS 0.9121
173 EGR 0.9120
174 E7Z 0.9119
175 5WU 0.9119
176 5XC 0.9118
177 VXX 0.9117
178 JND 0.9116
179 R8V 0.9116
180 IJZ 0.9115
181 0P6 0.9114
182 NGO 0.9111
183 6VD 0.9110
184 ISD 0.9109
185 DIU 0.9108
186 3AL 0.9108
187 AY4 0.9106
188 GAB 0.9106
189 KTW 0.9105
190 4ME 0.9105
191 R9Y 0.9104
192 1F1 0.9103
193 XAZ 0.9102
194 XIY 0.9102
195 SHA 0.9101
196 DIN 0.9101
197 SKA 0.9100
198 3HB 0.9100
199 ESI 0.9099
200 F69 0.9098
201 8TX 0.9098
202 IF7 0.9096
203 BTY 0.9094
204 KYA 0.9093
205 FA0 0.9092
206 6NT 0.9091
207 GAF 0.9090
208 5JQ 0.9089
209 PXL 0.9086
210 0HN 0.9086
211 HQJ 0.9086
212 4M0 0.9084
213 II6 0.9083
214 FOT 0.9083
215 PAB 0.9082
216 J9Q 0.9081
217 7N0 0.9079
218 PZI 0.9078
219 P84 0.9077
220 B55 0.9077
221 H7Y 0.9076
222 MR1 0.9076
223 7W1 0.9075
224 TTL 0.9070
225 GT0 0.9069
226 4HP 0.9069
227 TSU 0.9068
228 KIB 0.9068
229 J9T 0.9066
230 GXL 0.9064
231 DBH 0.9063
232 RSO 0.9063
233 S24 0.9062
234 15N 0.9062
235 8ZE 0.9062
236 AMG 0.9062
237 HQT 0.9062
238 61M 0.9061
239 AC6 0.9061
240 3IT 0.9060
241 52C 0.9056
242 K32 0.9056
243 GOX 0.9055
244 ASO 0.9055
245 HA5 0.9055
246 B2J 0.9055
247 5CU 0.9055
248 SOE 0.9054
249 ICO 0.9053
250 B57 0.9053
251 HJP 0.9052
252 9KH 0.9052
253 4Z4 0.9051
254 5QX 0.9051
255 XAN 0.9051
256 R9S 0.9049
257 DHR 0.9049
258 717 0.9049
259 WCE 0.9049
260 3HP 0.9048
261 3A9 0.9047
262 3NY 0.9047
263 5NU 0.9047
264 12Q 0.9044
265 PQK 0.9043
266 0FK 0.9042
267 Q6T 0.9042
268 AKH 0.9042
269 BMA 0.9041
270 NMJ 0.9040
271 FDK 0.9040
272 NVU 0.9040
273 5OB 0.9040
274 B53 0.9040
275 3HA 0.9040
276 DOB 0.9039
277 8NB 0.9038
278 5NI 0.9038
279 MRW 0.9038
280 FDB 0.9038
281 KJH 0.9037
282 IFL 0.9036
283 4VP 0.9036
284 82I 0.9036
285 67N 0.9036
286 GTQ 0.9036
287 JR2 0.9036
288 TYL 0.9035
289 JIF 0.9035
290 JB8 0.9034
291 GF4 0.9034
292 FUL 0.9034
293 YRL 0.9033
294 1M2 0.9033
295 FBW 0.9033
296 3DO 0.9031
297 KUF 0.9031
298 4MA 0.9031
299 ICB 0.9030
300 75K 0.9029
301 QBK 0.9029
302 NOY 0.9027
303 TSR 0.9027
304 FA1 0.9026
305 NBG 0.9025
306 FE DB1 0.9025
307 JDN 0.9024
308 AMH 0.9023
309 FH2 0.9022
310 ONR 0.9021
311 BZ3 0.9020
312 4J8 0.9020
313 PBZ 0.9020
314 Z82 0.9019
315 GZL 0.9018
316 BZ2 0.9018
317 0JD 0.9015
318 2ZM 0.9015
319 8CM 0.9014
320 SAN 0.9014
321 KGK 0.9014
322 FBS 0.9013
323 86J 0.9010
324 2HC 0.9009
325 P3K 0.9009
326 N7I 0.9009
327 1Y6 0.9008
328 3MB 0.9008
329 SYV 0.9007
330 3BZ 0.9007
331 I3A 0.9007
332 M1Q 0.9007
333 3Z8 0.9007
334 FBB 0.9006
335 DNF 0.9006
336 SBK 0.9005
337 HBD 0.9005
338 SVD 0.9004
339 LZM 0.9003
340 9ZE 0.9003
341 4P5 0.9002
342 8NX 0.9001
343 5RO 0.9001
344 5JL 0.9000
345 3F0 0.9000
346 XM0 0.9000
347 OHP 0.9000
348 94B 0.8999
349 2EC 0.8998
350 CXF 0.8998
351 2CZ 0.8997
352 209 0.8997
353 3AB 0.8995
354 0W1 0.8995
355 L7T 0.8995
356 BEA 0.8995
357 FHN 0.8994
358 ES2 0.8994
359 4KL 0.8994
360 MT0 0.8992
361 N8Y 0.8991
362 6FZ 0.8990
363 CFA 0.8989
364 HY1 0.8987
365 069 0.8987
366 GUN 0.8986
367 FCR 0.8985
368 9DG 0.8984
369 PA1 0.8983
370 BHA 0.8981
371 NIZ 0.8981
372 NFM 0.8980
373 K2T 0.8980
374 ZWZ 0.8980
375 4ZA 0.8980
376 Z5P 0.8980
377 6GU 0.8979
378 BSX 0.8978
379 6NI 0.8978
380 AJ2 0.8978
381 42C 0.8977
382 23A 0.8976
383 H8N 0.8975
384 DX4 0.8973
385 CLW 0.8972
386 HKD 0.8972
387 NQH 0.8970
388 ABI 0.8969
389 JAW 0.8969
390 AAS 0.8968
391 ET2 0.8968
392 JFD 0.8968
393 QY9 0.8967
394 ARP 0.8967
395 51R 0.8966
396 7NI 0.8966
397 0CU 0.8964
398 KKN 0.8964
399 GYE 0.8964
400 97T 0.8963
401 RBJ 0.8963
402 N2Z 0.8959
403 BRT 0.8959
404 45L 0.8958
405 3OC 0.8958
406 141 0.8958
407 268 0.8957
408 9PY 0.8957
409 495 0.8957
410 LCN 0.8956
411 7MU 0.8955
412 WOO 0.8954
413 2BG 0.8952
414 ALL 0.8952
415 BCU 0.8952
416 AIN 0.8952
417 8GK 0.8952
418 K5W 0.8952
419 42A 0.8951
420 F9Y 0.8950
421 UEG 0.8950
422 HNQ 0.8950
423 XXG 0.8949
424 UNC 0.8949
425 N2I 0.8949
426 OTR 0.8948
427 5NE 0.8948
428 6AP 0.8948
429 5RN 0.8947
430 L5V 0.8946
431 H33 0.8946
432 C2Y 0.8945
433 FBA 0.8945
434 HDH 0.8944
435 6RQ 0.8944
436 SW7 0.8944
437 8U3 0.8944
438 RIB 0.8944
439 5WY 0.8943
440 MAN 0.8942
441 P72 0.8940
442 ANN 0.8940
443 GLF 0.8939
444 GJZ 0.8939
445 KBB 0.8939
446 3R6 0.8938
447 92K 0.8937
448 5RG 0.8937
449 8XQ 0.8936
450 AMS 0.8935
451 8H8 0.8935
452 M1A 0.8935
453 SWA 0.8935
454 GTL 0.8934
455 4HC 0.8933
456 A2F 0.8933
457 2HQ 0.8932
458 1P8 0.8932
459 BNF 0.8932
460 MQB 0.8931
461 9FE 0.8931
462 8IG 0.8931
463 DFB 0.8931
464 1XM 0.8931
465 24W 0.8930
466 ABV 0.8929
467 2MI 0.8927
468 PH2 0.8926
469 HH5 0.8926
470 RAT 0.8925
471 M1E 0.8925
472 KJY 0.8925
473 3M0 0.8925
474 C2B 0.8923
475 263 0.8922
476 AZA 0.8922
477 6XI 0.8921
478 AX7 0.8920
479 PAC 0.8919
480 7D2 0.8919
481 1LQ 0.8919
482 TPA 0.8919
483 VGD 0.8918
484 K22 0.8918
485 3DM 0.8917
486 36E 0.8917
487 7HQ 0.8915
488 IOS 0.8915
489 SRO 0.8915
490 CFI 0.8915
491 5WV 0.8915
492 39O 0.8914
493 RHU 0.8914
494 MS9 0.8913
495 PNZ 0.8913
496 NTZ 0.8913
497 0LH 0.8912
498 12T 0.8912
499 1SQ 0.8912
500 60Q 0.8911
501 4WL 0.8911
502 54G 0.8910
503 270 0.8910
504 4JL 0.8910
505 ODO 0.8909
506 ISZ 0.8909
507 JKZ 0.8909
508 M6N 0.8908
509 KIA 0.8908
510 4ZC 0.8908
511 K17 0.8907
512 YH7 0.8906
513 MO8 0.8905
514 M5K 0.8905
515 5M0 0.8904
516 CXH 0.8904
517 12M 0.8903
518 7MX 0.8902
519 H4E 0.8902
520 B62 0.8902
521 P92 0.8901
522 BCP 0.8901
523 APS 0.8900
524 HC4 0.8900
525 4MU 0.8900
526 C2A 0.8900
527 BK9 0.8899
528 TTY 0.8898
529 36R 0.8898
530 GV9 0.8897
531 CKU 0.8897
532 92P 0.8897
533 0W8 0.8897
534 OVM 0.8896
535 DMD 0.8896
536 KFH 0.8896
537 XQI 0.8895
538 03V 0.8895
539 FAN 0.8894
540 SJ5 0.8894
541 7VS 0.8894
542 5VM 0.8893
543 505 0.8893
544 MAJ 0.8892
545 CTS 0.8892
546 AEG 0.8891
547 KP6 0.8891
548 6CS 0.8891
549 XCZ 0.8890
550 R8S 0.8890
551 XQ0 0.8890
552 5QY 0.8890
553 2O6 0.8889
554 OXZ 0.8889
555 JZ3 0.8888
556 G1P 0.8887
557 PRY 0.8886
558 COU 0.8885
559 5MK 0.8884
560 173 0.8884
561 1P3 0.8883
562 9TZ 0.8883
563 463 0.8883
564 JZ4 0.8882
565 IPB 0.8882
566 SR1 0.8882
567 P7Y 0.8881
568 ORN 0.8881
569 N5J 0.8881
570 C9E 0.8879
571 URS 0.8878
572 AH8 0.8878
573 R20 0.8877
574 BOA 0.8877
575 NDG 0.8877
576 INE 0.8876
577 5HN 0.8875
578 RM1 0.8875
579 ZB1 0.8874
580 5OF 0.8874
581 M1Z 0.8874
582 7B4 0.8874
583 FCB 0.8873
584 F12 0.8873
585 IGA 0.8873
586 NAG 0.8872
587 ESP 0.8872
588 DRL 0.8872
589 7VJ 0.8871
590 2HU 0.8871
591 OW4 0.8871
592 FBM 0.8870
593 HLD 0.8870
594 OGA 0.8869
595 2LY 0.8869
596 9MG 0.8869
597 E7S 0.8867
598 4JM 0.8867
599 4FS 0.8866
600 6DP 0.8864
601 QWN 0.8864
602 MEW 0.8864
603 948 0.8863
604 PHU 0.8863
605 3ID 0.8863
606 ISN 0.8863
607 PZM 0.8861
608 GXY 0.8861
609 FYU 0.8861
610 HIS 0.8861
611 0FN 0.8860
612 PEL 0.8860
613 3RI 0.8859
614 MWJ 0.8858
615 ALE 0.8858
616 1P7 0.8858
617 BPN 0.8858
618 SLS 0.8857
619 8GC 0.8857
620 6TZ 0.8857
621 JBK 0.8856
622 TFU 0.8855
623 FRU 0.8855
624 7W4 0.8855
625 SNO 0.8855
626 2HG 0.8854
627 NID 0.8854
628 M4E 0.8854
629 AZ8 0.8854
630 ES5 0.8853
631 ES7 0.8853
632 1XN 0.8853
633 1AL 0.8852
634 MSR 0.8852
635 YTX 0.8851
636 5NS 0.8850
637 BHO 0.8850
638 3Z7 0.8850
639 BE2 0.8850
640 EDR 0.8849
641 E35 0.8849
642 2FY 0.8848
643 HPA 0.8848
644 RM4 0.8847
645 2AQ 0.8847
646 KDV 0.8846
647 5IQ 0.8846
648 1XA 0.8846
649 E5X 0.8845
650 O2A 0.8845
651 428 0.8844
652 826 0.8843
653 M2K 0.8843
654 PE0 0.8843
655 293 0.8843
656 NLA 0.8842
657 OTW 0.8842
658 HZQ 0.8841
659 J6W 0.8841
660 HMH 0.8841
661 3PF 0.8841
662 RNS 0.8840
663 DBJ 0.8840
664 1LM 0.8840
665 VK3 0.8840
666 AQO 0.8840
667 IFM 0.8839
668 PRF 0.8839
669 PEA 0.8839
670 IPZ 0.8838
671 MFB 0.8838
672 4YS 0.8837
673 LRH 0.8836
674 94W 0.8835
675 ES1 0.8835
676 2PG 0.8834
677 D48 0.8834
678 9KT 0.8833
679 25W 0.8833
680 TZF 0.8832
681 JBH 0.8832
682 CFF 0.8832
683 TEP 0.8832
684 MZG 0.8831
685 SX1 0.8830
686 1NP 0.8830
687 PBC 0.8830
688 IBM 0.8830
689 GLN 0.8829
690 258 0.8829
691 DIE 0.8829
692 M0W 0.8829
693 HHT 0.8829
694 GIF 0.8828
695 5Q0 0.8828
696 DQU 0.8828
697 2ZQ 0.8828
698 H42 0.8827
699 SAL 0.8827
700 FK8 0.8826
701 5SG 0.8826
702 3FH 0.8824
703 XQG 0.8823
704 XHP 0.8823
705 Y8I 0.8822
706 174 0.8822
707 DBX 0.8820
708 F81 0.8820
709 GDL 0.8819
710 290 0.8819
711 0GZ 0.8819
712 5JC 0.8818
713 QXW 0.8818
714 4JQ 0.8817
715 NDM 0.8817
716 AFR 0.8816
717 KJ5 0.8815
718 1X7 0.8814
719 HHA 0.8814
720 LT2 0.8814
721 XYP 0.8814
722 H5B 0.8813
723 J5I 0.8813
724 4BZ 0.8813
725 D07 0.8813
726 2FQ 0.8812
727 JPZ 0.8812
728 HLZ 0.8811
729 RNO 0.8811
730 H6B 0.8811
731 OCH 0.8810
732 HQ9 0.8810
733 4XH 0.8808
734 FUC 0.8808
735 ESX 0.8808
736 0FO 0.8808
737 HDL 0.8807
738 HMU 0.8807
739 UNJ 0.8807
740 M4S 0.8806
741 2F6 0.8806
742 CFP 0.8806
743 BEZ 0.8806
744 AZG 0.8804
745 GLU 0.8803
746 2IT 0.8803
747 HXX 0.8803
748 XBZ 0.8802
749 PDC 0.8802
750 HHR 0.8801
751 G3E 0.8800
752 O72 0.8800
753 LIP 0.8798
754 512 0.8798
755 GLY PRO 0.8798
756 NSP 0.8797
757 24B 0.8797
758 GJS 0.8796
759 44V 0.8796
760 G5V 0.8796
761 KJU 0.8796
762 RB5 0.8795
763 SXS 0.8795
764 LI6 0.8794
765 8HC 0.8793
766 TBS 0.8793
767 PIM 0.8792
768 QOS 0.8792
769 RXA 0.8792
770 Q24 0.8791
771 TIU 0.8790
772 JA8 0.8789
773 4JJ 0.8789
774 F4E 0.8789
775 BR9 0.8788
776 BEN 0.8788
777 M4T 0.8787
778 MMA 0.8787
779 CBF 0.8786
780 BNS 0.8786
781 NDH 0.8786
782 2D3 0.8786
783 GWM 0.8785
784 2YU 0.8785
785 2GS 0.8785
786 HHH 0.8785
787 HQY 0.8785
788 EA1 0.8785
789 AKG 0.8784
790 TH7 0.8784
791 JKE 0.8784
792 GM7 0.8783
793 CPZ 0.8783
794 DNA 0.8783
795 EVF 0.8780
796 6LW 0.8780
797 F9P 0.8780
798 OVP 0.8780
799 2DR 0.8780
800 M1H 0.8779
801 7ZE 0.8779
802 A65 0.8778
803 1LN 0.8778
804 CLZ 0.8776
805 PQ0 0.8776
806 M0Q 0.8776
807 AMC 0.8776
808 4CL 0.8774
809 DA4 0.8774
810 HH8 0.8774
811 27Y 0.8773
812 NQ 0.8773
813 OTD 0.8773
814 6ME 0.8772
815 A9P 0.8770
816 DGL 0.8769
817 MCT 0.8769
818 NK 0.8767
819 JAE 0.8766
820 4NM 0.8765
821 HPT 0.8765
822 KG1 0.8765
823 FBV 0.8765
824 JZ2 0.8764
825 9FL 0.8764
826 HT4 0.8763
827 DHC 0.8763
828 EYK 0.8763
829 4YO 0.8762
830 SE2 0.8761
831 39A 0.8761
832 MNP 0.8761
833 TM7 0.8760
834 QMP 0.8760
835 LZ2 0.8760
836 7WG 0.8760
837 QBM 0.8759
838 4JC 0.8758
839 LAO 0.8758
840 44W 0.8758
841 BTE 0.8758
842 SEP 0.8757
843 2AC 0.8757
844 PIY 0.8756
845 5B1 0.8756
846 V1T 0.8756
847 M2H 0.8756
848 MIG 0.8755
849 UNU 0.8755
850 8OZ 0.8753
851 9R5 0.8753
852 BZX 0.8753
853 E1T 0.8753
854 0R0 0.8753
855 ABF 0.8752
856 QMS 0.8752
857 I1E 0.8752
858 SWD 0.8751
859 AGK 0.8751
860 GIO 0.8751
861 10L 0.8749
862 680 0.8749
863 MUA 0.8748
864 NYL 0.8748
865 CTL 0.8748
866 IPD 0.8748
867 XQK 0.8747
868 8XL 0.8747
869 4TU 0.8747
870 2SX 0.8746
871 H76 0.8746
872 6PC 0.8746
873 A1U 0.8745
874 HA7 0.8745
875 11S 0.8744
876 PYD 0.8743
877 PD2 0.8743
878 4JT 0.8742
879 5LA 0.8742
880 CWJ 0.8742
881 DMJ 0.8741
882 5WX 0.8741
883 2BX 0.8740
884 JRB 0.8740
885 FUF 0.8740
886 TZE 0.8739
887 A29 0.8738
888 DPZ 0.8737
889 5CL 0.8737
890 GOG 0.8737
891 GJP 0.8737
892 SMN 0.8737
893 37T 0.8736
894 4BY 0.8734
895 URF 0.8734
896 FDR 0.8734
897 SRT 0.8734
898 K37 0.8733
899 PHH 0.8733
900 L46 0.8733
901 XXR 0.8733
902 1DW 0.8733
903 NCA 0.8733
904 PRA 0.8733
905 ZZT 0.8732
906 34A 0.8731
907 MNM 0.8729
908 BPY 0.8728
909 QAT 0.8728
910 6KT 0.8728
911 4HO 0.8727
912 MWM 0.8727
913 MQN 0.8726
914 XYD 0.8726
915 TOF 0.8726
916 3U4 0.8726
917 S2G 0.8725
918 5MH 0.8725
919 CH9 0.8725
920 BAM 0.8724
921 SG2 0.8723
922 BDF 0.8722
923 TLD 0.8721
924 OA3 0.8721
925 3ZB 0.8721
926 ADE 0.8721
927 MWP 0.8719
928 EXO 0.8719
929 A9O 0.8719
930 6MP 0.8719
931 ES4 0.8718
932 259 0.8716
933 1MC 0.8716
934 NIG 0.8715
935 MXD 0.8714
936 GCO 0.8714
937 GZ8 0.8713
938 X09 0.8713
939 ZYR 0.8713
940 12B 0.8713
941 MVN 0.8713
942 7HP 0.8713
943 KBZ 0.8712
944 TGX 0.8711
945 3SK 0.8708
946 E4P 0.8707
947 14O 0.8707
948 5MI 0.8707
949 4ZE 0.8706
950 I6G 0.8706
951 2KA 0.8705
952 5GU 0.8705
953 SN4 0.8705
954 R2P 0.8704
955 2CL 0.8704
956 6AI 0.8703
957 WBU 0.8703
958 FEH 0.8703
959 VNJ 0.8703
960 4RU 0.8702
961 QAS 0.8702
962 PZA 0.8702
963 286 0.8702
964 LDR 0.8701
965 1A7 0.8701
966 NIO 0.8701
967 M3Q 0.8701
968 MSN 0.8700
969 329 0.8699
970 GO8 0.8699
971 CIY 0.8699
972 4AV 0.8698
973 5H1 0.8697
974 FB1 0.8696
975 TCZ 0.8695
976 MHK 0.8695
977 R2B 0.8695
978 AZF 0.8694
979 GNM 0.8693
980 I7A 0.8693
981 9AP 0.8693
982 0TU 0.8693
983 2MP 0.8693
984 STT 0.8693
985 GYP 0.8692
986 5MB 0.8692
987 TH0 0.8692
988 9RW 0.8692
989 9DA 0.8692
990 PM6 0.8692
991 CEE 0.8691
992 F60 0.8690
993 M5H 0.8690
994 YO5 0.8688
995 271 0.8688
996 ES9 0.8687
997 449 0.8687
998 7WA 0.8687
999 X05 0.8686
1000 43M 0.8686
1001 I3C 0.8686
1002 QUS 0.8685
1003 51F 0.8685
1004 TRA 0.8684
1005 68A 0.8683
1006 XUL 0.8683
1007 1HN 0.8681
1008 FB2 0.8681
1009 9HX 0.8681
1010 49O 0.8679
1011 LSA 0.8679
1012 JU2 0.8678
1013 N1E 0.8678
1014 2AK 0.8678
1015 4BL 0.8677
1016 BP1 0.8676
1017 4JO 0.8676
1018 27B 0.8675
1019 RMN 0.8675
1020 ICP 0.8675
1021 PYQ 0.8674
1022 NPA 0.8674
1023 MFU 0.8673
1024 HPS 0.8673
1025 275 0.8673
1026 PFL 0.8672
1027 GVG 0.8671
1028 AMQ 0.8670
1029 A1Y 0.8670
1030 7I2 0.8670
1031 MT5 0.8670
1032 ZZZ 0.8670
1033 CKX 0.8668
1034 I3E 0.8667
1035 ADZ 0.8667
1036 4SV 0.8667
1037 BSP 0.8666
1038 TRC 0.8665
1039 H4N 0.8665
1040 HCI 0.8665
1041 ERH 0.8665
1042 PXM 0.8663
1043 PH3 0.8662
1044 R8A 0.8662
1045 PMB 0.8662
1046 ES6 0.8659
1047 2K4 0.8658
1048 SNU 0.8657
1049 YSO 0.8657
1050 FBG 0.8655
1051 M6Z 0.8654
1052 GTZ 0.8654
1053 PYF 0.8654
1054 HBX 0.8654
1055 DC5 0.8654
1056 SFU 0.8653
1057 AOS 0.8652
1058 1WC 0.8652
1059 ABN 0.8652
1060 K8X 0.8651
1061 6R8 0.8650
1062 95Z 0.8650
1063 ZON 0.8649
1064 SKF 0.8649
1065 13X 0.8649
1066 36Y 0.8648
1067 FK1 0.8647
1068 TDR 0.8647
1069 YQA 0.8647
1070 S0E 0.8646
1071 692 0.8646
1072 JBE 0.8646
1073 F6P 0.8646
1074 CKA 0.8645
1075 TT4 0.8645
1076 TQU 0.8644
1077 JG8 0.8642
1078 1U6 0.8642
1079 OAA 0.8639
1080 ASP 0.8639
1081 IP0 0.8638
1082 BRV 0.8638
1083 SS2 0.8638
1084 5ZE 0.8638
1085 2ZX 0.8637
1086 C1M 0.8636
1087 YPN 0.8636
1088 NCD 0.8635
1089 J9W 0.8634
1090 GCW 0.8631
1091 JB5 0.8631
1092 AC0 0.8628
1093 X0W 0.8627
1094 8WZ 0.8626
1095 7WV 0.8625
1096