Receptor
PDB id Resolution Class Description Source Keywords
5C28 1.56 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 6-CHLORO-2-CYCLOPROPYL-5-METHYL-PYRIMID HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
MG B:802;
A:802;
Part of Protein;
Part of Protein;
none;
none;
submit data
24.305 Mg [Mg+2...
ZN B:801;
A:801;
Part of Protein;
Part of Protein;
none;
none;
submit data
65.409 Zn [Zn+2...
4XV A:803;
Valid;
none;
Ki = 2.2 uM
183.638 C8 H10 Cl N3 Cc1c(...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C2H 2.09 Å EC: 3.1.4.17 PDE10 COMPLEXED WITH 6-CHLORO-N-[(2,4-DIMETHYLTHIAZOL-5-YL)M METHYL-2-[3-(2-QUINOLYL)PROPOXY]PYRIMIDIN-4-AMINE HOMO SAPIENS PHOSPHODIESTERASE INHIBITOR COMPLEX HYDROLASE-HYDROLASE ICOMPLEX
Ref.: DISCOVERY AND OPTIMIZATION OF A SERIES OF PYRIMIDIN PHOSPHODIESTERASE 10A (PDE10A) INHIBITORS THROUGH F SCREENING, STRUCTURE-BASED DESIGN, AND PARALLEL SYN J.MED.CHEM. V. 58 7888 2015
Members (67)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 19 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
70% Homology Family (77)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 15 families.
1 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
2 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
3 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
4 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
5 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
6 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
7 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
8 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
9 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
10 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
11 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
12 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
13 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
14 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
15 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
16 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
17 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
18 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
19 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
20 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
21 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
22 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
23 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
24 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
25 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
26 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
27 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
28 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
29 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
30 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
31 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
32 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
33 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
34 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
35 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
36 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
37 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
38 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
39 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
40 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
41 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
42 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
43 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
44 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
45 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
46 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
47 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
48 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
49 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
50 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
51 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
52 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
53 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
54 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
55 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
56 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
57 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
58 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
59 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
60 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
61 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
62 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
63 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
64 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
65 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
66 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
67 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
68 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
69 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
70 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
71 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
72 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
73 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
74 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
75 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
76 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
77 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
50% Homology Family (230)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 10 families.
1 2CHM ic50 = 5.5 nM 3P4 C23 H29 N6 O3 CCc1c2c([n....
2 3TGG - 0H3 C23 H31 N5 O4 CCCOCCN1c2....
3 3HDZ ic50 = 51 nM PD6 C18 H19 N3 O CCCCN1C=CC....
4 3TGE ic50 = 0.07 nM TGE C24 H32 N6 O4 CCCOCCN1c2....
5 3B2R - VDN C23 H32 N6 O4 S CCCc1nc(c2....
6 2H44 ic50 = 1.7 uM 7CA C27 H32 O10 C[C@H]1[C@....
7 2H42 ic50 = 2.4 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
8 1T9S - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
9 4MD6 ic50 = 17 nM 24E C22 H15 N O3 S c1ccc2c(c1....
10 1UHO Kd ~ 0.6 nM VDN C23 H32 N6 O4 S CCCc1nc(c2....
11 1UDT Kd ~ 0.5 nM VIA C22 H30 N6 O4 S CCCc1c2c(n....
12 1RKP - IBM C10 H14 N4 O2 CC(C)CN1c2....
13 4IA0 ic50 = 77 nM 5BB C25 H37 Br N4 O4 S CCCCCCCCC1....
14 3SIE ic50 = 13.3 nM 5BO C20 H27 Br N4 O4 S CCCOc1ccc(....
15 3HC8 ic50 = 2.9 nM PD4 C24 H32 N6 O4 CCCOCCN1c2....
16 1XP0 ic50 = 0.001 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
17 1XOZ ic50 = 0.0012 uM CIA C22 H19 N3 O4 CN1CC(=O)N....
18 6L6E - E6L C23 H26 Cl N7 O3 COc1ccc(cc....
19 4I9Z ic50 = 18.2 nM 5BA C23 H31 Br N4 O3 CCCOc1ccc(....
20 1TBF - VIA C22 H30 N6 O4 S CCCc1c2c(n....
21 4OEX Kd = 0.000000064 M 5EO C20 H28 N4 O4 S CCCOc1ccc(....
22 4G2Y ic50 > 1000 nM NI5 C21 H28 N4 O4 S CCCOc1ccc(....
23 4OEW Kd = 0.000000064 M 5IO C20 H27 I N4 O4 S CCCOc1ccc(....
24 1Y2B ic50 = 82 uM DEE C8 H12 N2 O2 CCOC(=O)c1....
25 6IMD ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
26 1TBB - ROL C16 H21 N O3 COc1ccc(cc....
27 4W1O - 3GJ C19 H17 Cl2 N3 O4 CCc1cc(on1....
28 5LBO - 6M5 C33 H40 N6 O4 COc1ccc(cc....
29 6IMT ic50 = 0.25 uM AK0 C22 H23 F N2 O3 COc1cc2c(c....
30 6RCW - JX2 C30 H33 N3 O4 COc1ccc(cc....
31 6HWO Ki = 0.00000079 M FFZ C28 H29 N3 O3 CC(C)N1C(=....
32 6IMI ic50 = 26.1 uM AH6 C13 H17 N O3 CCOc1cc2c(....
33 6IMB ic50 = 58.5 uM AH9 C12 H15 N O3 COc1cc2c(c....
34 1ZKN - IBM C10 H14 N4 O2 CC(C)CN1c2....
35 6NJJ - KR7 C21 H15 Cl F3 N O2 c1cc(cc(c1....
36 3SL4 ic50 = 0.027 uM JN4 C21 H21 N3 O4 S C=CNC(=O)N....
37 1XOQ ic50 = 0.68 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
38 1Y2E ic50 = 0.16 uM 5DE C14 H17 N3 O2 CCOC(=O)c1....
39 1PTW - AMP C10 H14 N5 O7 P c1nc(c2c(n....
40 6FTW - E6Z C25 H29 N3 O3 COc1ccc(cc....
41 5WQA ic50 = 0.011 uM J20 C36 H26 O5 COc1ccc(cc....
42 1Y2D ic50 = 2 uM 4DE C15 H18 N2 O3 CCOC(=O)c1....
43 6F8W ic50 = 23 uM D0E C22 H29 N3 O4 COc1ccc(cc....
44 6AKR - A0O C15 H16 O3 CC(=CCc1c(....
45 1XON ic50 = 0.021 nM PIL C18 H18 Cl2 N2 O3 COc1ccc(cc....
46 6NJH - KRD C19 H18 Cl N5 O CCc1nc(nc(....
47 1TB7 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
48 6FDC ic50 = 2.3 uM DD5 C22 H29 F2 N3 O4 c1cc(c(cc1....
49 6IND ic50 = 0.24 uM AKO C23 H26 N2 O3 Cc1ccc2c(c....
50 6INK ic50 = 0.27 uM AKU C22 H24 N2 O3 COc1cc2c(c....
51 6IMR ic50 = 4.3 uM AJX C23 H26 N2 O3 COc1cc2c(c....
52 1XOR ic50 = 0.39 uM ZAR C12 H10 F2 N2 O3 COc1cc(ccc....
53 3G4K ic50 = 288 nM ROL C16 H21 N O3 COc1ccc(cc....
54 1Y2C ic50 = 0.27 uM 3DE C14 H17 N2 O2 CCOC(=O)c1....
55 2FM0 ic50 = 0.4 nM M98 C23 H18 F8 N2 O4 S c1cc(c[n+]....
56 6KJZ ic50 = 420 nM MKU C24 H26 O6 CC(=CCc1c2....
57 6F8T ic50 = 7 uM CZT C22 H34 N2 O5 C[C@@H]1CN....
58 1Y2K ic50 = 0.021 uM 7DE C14 H15 N3 O4 CCOC(=O)c1....
59 1XOM ic50 = 0.011 uM CIO C20 H25 N O4 COc1ccc(cc....
60 6KK0 ic50 = 17 nM M36 C31 H36 O8 CC(=CCc1c2....
61 2PW3 - CMP C10 H12 N5 O6 P c1nc(c2c(n....
62 6IM6 ic50 = 20.7 uM AH3 C13 H17 N O3 CCOc1cc2c(....
63 1Q9M ic50 = 0.33 uM ROL C16 H21 N O3 COc1ccc(cc....
64 4WCU ic50 = 3 nM 3KQ C24 H22 Cl2 N2 O5 COc1ccc(c(....
65 6F8U ic50 = 0.8 uM CZQ C21 H28 F2 N2 O5 C[C@@H]1CN....
66 6INM ic50 = 0.51 uM AKU C22 H24 N2 O3 COc1cc2c(c....
67 2FM5 ic50 = 43 nM M99 C23 H18 F8 N2 O4 S c1cc(c[n+]....
68 3G4I - D71 C19 H13 N5 O4 c1cc(cc(c1....
69 6F6U ic50 = 16 uM CV8 C21 H30 N2 O5 C[C@@H]1CN....
70 6F8V ic50 = 16 uM D0B C24 H33 N3 O4 C[C@@H]1CN....
71 6IMO ic50 = 0.65 uM AJL C21 H22 N2 O3 COc1cc2c(c....
72 3G4L ic50 = 5.8 nM ROF C17 H14 Cl2 F2 N2 O3 c1cc(c(cc1....
73 4G2J ic50 = 11 nM 0WF C21 H25 N5 O2 C[C@H](C1=....
74 3K3H - BYE C15 H12 Cl F3 N4 O C[C@@H](CC....
75 3DY8 - IBM C10 H14 N4 O2 CC(C)CN1c2....
76 3DYN - PCG C10 H12 N5 O7 P c1nc2c(n1[....
77 3DYQ - PCG C10 H12 N5 O7 P c1nc2c(n1[....
78 3JSW ic50 = 66 nM JAR C20 H25 N5 O C[C@@H]1C[....
79 3DYS - IBM C10 H14 N4 O2 CC(C)CN1c2....
80 4E90 ic50 = 8 nM 7RG C20 H25 N7 O2 C[C@@H]1C[....
81 5U7K ic50 = 7.1 nM 7Y1 C20 H22 N6 O CCCOc1cncc....
82 6CYD ic50 = 2 nM FKG C16 H15 F3 N4 O2 CC1=Nc2c(c....
83 5TZA ic50 = 0.001 uM 7OG C22 H21 N5 O Cc1cc(n2c(....
84 6C7G ic50 = 18.2 nM EOY C31 H34 Cl N5 O2 Cc1c2nnc(n....
85 5VP0 ic50 = 0.61 nM 9GJ C19 H18 F4 N4 O5 COC[C@H](c....
86 5U00 ic50 = 0.002 uM 7OV C18 H15 F3 I N5 O Cc1cc(n2c(....
87 5U7I ic50 = 66.6 nM 7XS C20 H25 N5 O2 CC(C)Cc1c2....
88 5U7J ic50 = 389.6 nM 7XV C18 H22 N4 O2 CC(C)Cc1nn....
89 5XKM ic50 = 24 nM 87R C18 H17 F3 N4 O2 CC[C@H](c1....
90 6B98 Ki = 22.4 uM D07 C7 H8 Cl N5 CNc1c2cnn(....
91 6B96 Ki = 14.3 nM CZV C15 H11 Cl F3 N5 c1cc(ccc1C....
92 5U7D ic50 = 0.5 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
93 6ZQZ ic50 = 24 nM QOQ C18 H19 Cl F2 N6 Cc1cc(cc(n....
94 5TZX ic50 = 0.052 uM 7OY C18 H15 Cl F3 N5 O Cc1cc(n2c(....
95 6C7I ic50 = 0.38 nM EP7 C22 H22 Cl N5 O2 Cc1c2nnc(n....
96 6CYB ic50 = 0.96 nM FKV C16 H12 F6 N4 O2 C[C@@H](c1....
97 6B97 Ki = 0.237 uM CZY C15 H13 Cl F3 N5 C[C@H](c1c....
98 5TZZ ic50 = 0.014 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
99 5VP1 ic50 = 0.51 nM 9GA C22 H22 F3 N7 O3 Cc1cn2c(c(....
100 4HTX ic50 = 4.7 nM 19F C27 H32 N4 O4 Cc1c2n(c(n....
101 6EZF - C6Z C11 H8 Cl2 N2 S c1cc(c(cc1....
102 5TZ3 ic50 = 0.14 uM 7OM C22 H22 N6 O Cc1cc(n2c(....
103 5TZH ic50 = 0.679 uM 7OP C18 H16 F3 N5 O Cc1cc(n2c(....
104 6ZND ic50 = 66 nM QMZ C20 H23 N5 O4 COc1cc(cc(....
105 5TZC ic50 = 0.008 uM 7OJ C18 H15 Br F3 N5 O Cc1cc(n2c(....
106 3ITU ic50 = 40 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
107 6C7F ic50 = 0.00000001 M EOS C22 H22 Cl N5 O2 Cc1c2nnc(n....
108 6C7E ic50 = 0.24 nM EOG C18 H14 Cl N5 O Cc1c2nnc(n....
109 6C7J ic50 = 1.32 nM EPV C25 H28 Cl N5 O2 Cc1c2nnc(n....
110 4JIB ic50 = 45 nM 1L6 C23 H28 N6 O2 CCC(C)(C)c....
111 5U7L ic50 = 4.9 nM 7Y4 C24 H30 N8 CCc1ccc(cc....
112 4D09 ic50 = 1.7 nM 788 C24 H19 N5 O Cc1c2nnc(n....
113 6C7D ic50 = 0.17 nM EOJ C27 H26 Cl N5 O Cc1c2nnc(n....
114 5TZW ic50 = 0.987 uM 7P4 C18 H15 F4 N5 O Cc1cc(n2c(....
115 6CYC ic50 = 14 nM FKJ C15 H13 F3 N4 O3 C[C@@H](c1....
116 4D08 ic50 = 10 nM Q2T C24 H28 N6 O2 CCCCOc1cc(....
117 5I2R ic50 = 0.019 uM 67A C20 H13 F3 N4 O2 c1ccc(cc1)....
118 4FCB ic50 = 2.9 nM 0T7 C25 H24 N4 O CCCc1nc(c2....
119 4LM3 Ki = 1200 uM 9ZE C10 H10 O3 CC(=O)c1cc....
120 5C29 Ki = 880 nM 4XY C11 H16 Cl N3 CCCNc1c(c(....
121 4MSC Ki = 1.1 uM 2ZT C19 H14 N2 O c1ccc2c(c1....
122 2OUQ - 5GP C10 H14 N5 O8 P c1nc2c(n1[....
123 4MRW Ki = 500 uM MRW C9 H6 Cl N O c1cc2c(ccn....
124 6MSC ic50 = 21 nM JY7 C17 H14 F N5 O Cc1cnccc1c....
125 5C2E Ki = 2 nM 4Y1 C18 H20 Cl N5 O S Cc1c(nc(nc....
126 4LKQ Ki = 450 uM 1XM C5 H5 N5 S c1c2c([nH]....
127 3LXG ic50 = 7.28 nM Z73 C15 H18 N4 O CCCc1nc(c2....
128 5AXP ic50 = 0.94 nM 4LK C23 H18 F N5 O4 COC1=CN(N=....
129 4ZO5 Ki = 0.15 nM 4Q0 C28 H25 N3 O5 CC(C)Oc1cc....
130 5C1W Ki = 8.7 uM 4XS C8 H8 Cl2 N2 Cc1c(nc(nc....
131 3UI7 Ki = 1 nM C1L C18 H22 N4 O2 Cc1cc(cc2c....
132 2OUY - CMP C10 H12 N5 O6 P c1nc(c2c(n....
133 3SNL ic50 = 0.7 nM 548 C19 H14 Cl F3 N4 Cc1cnccc1c....
134 4LM4 Ki = 910 uM JPZ C8 H6 N2 O c1ccc2c(c1....
135 2OUN - AMP C10 H14 N5 O7 P c1nc(c2c(n....
136 6MSA ic50 = 5 nM JY4 C12 H12 N4 O2 Cc1c2c3cc(....
137 5EDI ic50 = 0.3 nM 5M9 C17 H22 Cl N7 Cc1cc(c(n2....
138 2OUR - CMP C10 H12 N5 O6 P c1nc(c2c(n....
139 2Y0J ic50 = 12 nM AXC C18 H14 N6 S Cc1nc2c3cc....
140 4FCD ic50 = 0.28 nM 0T6 C18 H15 Cl N4 O2 Cc1c2nnc3c....
141 5B4L ic50 = 0.76 nM 6DW C28 H27 N7 O2 c1ccc(cc1)....
142 5C2H Ki = 0.0082 nM 4XU C23 H24 Cl N5 O S Cc1c(nc(nc....
143 4YS7 ic50 = 0.001 uM 4GK C20 H19 N7 Cc1cnc(c2n....
144 5EDH - 5MF C17 H24 N8 CCc1cnc(n2....
145 4PHW ic50 = 0.1 nM 2W1 C24 H21 N3 O3 c1ccc2c(c1....
146 4BBX ic50 = 60 nM LKF C18 H24 N6 O2 Cc1c(n2ccn....
147 5DH5 Ki = 0.23 nM 5AY C20 H21 N7 O Cn1cc(cn1)....
148 4P1R ic50 = 4.1 nM 2KR C19 H17 N5 O Cc1ccc(nc1....
149 6KDX ic50 = 294 nM D6X C18 H18 N6 Cc1cc(n2c(....
150 4LLP Ki = 16 uM 4ZE C7 H9 N O Cc1cc(ccc1....
151 5UWF ic50 = 0.059 uM 8Q7 C22 H19 F2 N5 O3 S COc1ccc(cc....
152 4MSH Ki = 210 uM 2D0 C7 H5 Cl N2 S c1cc2c(c(c....
153 5AXQ ic50 = 0.08 nM 4LP C28 H26 F N5 O3 CC1(c2c(cc....
154 4LM2 Ki = 940 uM 8ZE C9 H10 O3 c1cc2c(cc1....
155 4YQH ic50 = 0.009 uM 4F7 C19 H16 N4 c1ccc(cc1)....
156 5C2A Ki = 4.8 nM 4Y2 C14 H17 Cl N4 S Cc1c(nc(nc....
157 4DDL ic50 = 4.9 nM 0JQ C24 H30 N4 O3 Cc1cc(cnc1....
158 4P0N ic50 = 3.4 nM 1IR C18 H17 N5 O S COc1nc2ccc....
159 5EDG - 5MG C20 H12 Cl F3 N4 O2 c1ccc(cc1)....
160 6K9U - D4L C25 H29 N7 O Cc1ccc2c(c....
161 4LLX Ki = 1300 uM 5ZE C6 H9 N3 Cc1cc(nc(n....
162 5C28 Ki = 2.2 uM 4XV C8 H10 Cl N3 Cc1c(nc(nc....
163 2OUU - 35G C10 H12 N5 O7 P c1nc2c(n1[....
164 4MVH ic50 = 4.5 nM 2F5 C22 H19 N5 O3 c1ccc2c(c1....
165 4HEU ic50 = 0.097 nM 15J C24 H25 N5 O2 c1ccc2c(c1....
166 4LLJ Ki = 380 uM 1XN C8 H9 N3 c1ccc2c(c1....
167 3SNI ic50 = 11 nM 546 C18 H17 N5 O Cc1ccncc1c....
168 4HF4 ic50 = 2.4 nM 15H C24 H25 N5 O2 S C[C@@H](C1....
169 3SN7 ic50 = 0.7 nM 540 C19 H17 F N4 O Cc1cnccc1c....
170 4AEL ic50 = 12 nM 4HN C23 H17 N3 O2 CCOc1ccccc....
171 4LLK Ki = 990 uM MEW C9 H8 N2 O CC1=Nc2ccc....
172 4MSA Ki = 500 uM 2ZM C7 H5 N3 O2 c1cc2c(cc1....
173 4MS0 Ki = 410 uM 2ZX C4 H5 Cl N4 c1c(nc(nc1....
174 4LM0 Ki = 560 uM 5NI C7 H5 N3 O2 c1cc2c(cc1....
175 4DFF Ki = 35 nM 0JP C16 H15 N3 O2 S COc1cc2c(c....
176 3WI2 ic50 = 92 nM P98 C26 H23 N3 O CC(C)c1nc2....
177 4MRZ Ki = 300 uM 2ZV C6 H7 N3 O2 Cc1ccnc(c1....
178 4LM1 Ki = 590 uM 7ZE C9 H6 N2 O2 c1cc2c(ccc....
179 5DH4 Ki = 58 nM 5AV C12 H12 Cl N5 S Cc1c(sc(n1....
180 5XUJ - 8G6 C13 H10 Cl N3 Cc1cc2nccc....
181 3UUO Ki = 11 nM 0CV C17 H21 N5 O Cc1cc(cc2c....
182 4MSN Ki = 94 uM 2ZQ C9 H6 N2 O2 c1cc2cccnc....
183 4XY2 ic50 = 8 nM 490 C25 H23 N5 O2 Cn1cc(c(n1....
184 5LAQ Ki = 0.63 nM 6M5 C33 H40 N6 O4 COc1ccc(cc....
185 3SHZ ic50 = 35.9 nM 5CO C20 H27 Cl N4 O4 S CCCOc1ccc(....
186 4G2W ic50 = 1.6 nM NI0 C22 H32 N4 O4 S CCCOc1ccc(....
187 3QI4 ic50 = 117.2 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
188 4QGE Ki = 0.5 nM 35O C20 H24 N6 O3 C[C@H](C(=....
189 3QI3 - PDB C15 H12 Cl F3 N4 O C[C@H](CC1....
190 4Y86 ic50 = 58 nM 49E C18 H20 Cl N5 O CC(c1ccc(c....
191 3ECN ic50 = 698 uM IBM C10 H14 N4 O2 CC(C)CN1c2....
192 3HQW ic50 = 35 nM PF4 C21 H18 N2 O2 S COc1ccc(cc....
193 3QPO ic50 = 247 nM PFR C27 H28 N4 O2 COc1cc2c(c....
194 2OVV Ki = 12 nM PFH C24 H23 N3 O3 COc1cc2c(c....
195 3HR1 ic50 = 0.37 nM PF9 C25 H20 N4 O Cn1cc(c(n1....
196 3QPN ic50 = 17 nM PFK C20 H17 N3 O2 COc1cc2cnc....
197 3HQZ ic50 = 0.42 nM PF8 C24 H18 N4 O c1ccc2c(c1....
198 2O8H Ki = 25 nM 227 C24 H29 N5 O4 S CN1CCN(CC1....
199 3HQY ic50 = 11.5 nM PF6 C25 H20 N4 O c1ccc2c(c1....
200 2OVY Ki = 4 nM PFJ C22 H21 N5 O3 COc1cc2c(c....
201 3QPP ic50 = 12 nM PFW C31 H30 N4 O2 COc1cc2c(c....
202 2QYK ic50 = 3.3 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
203 3GWT ic50 = 7.94 pM 066 C27 H26 N4 O5 S Cc1cc(cc2c....
204 3WD9 ic50 = 8.3 nM QPC C24 H27 N5 O2 CC(C)(C)CN....
205 4KP6 ic50 = 0.87 nM 1S1 C12 H17 N9 CCC(CC)(C#....
206 4NW7 ic50 = 237 nM 2O5 C20 H17 Cl N4 O2 c1cc(cc(c1....
207 3FRG ic50 = 3.98 nM SK4 C18 H17 N3 O4 S COc1cccc(c....
208 1RO9 - 8BR C10 H13 Br N5 O7 P c1nc(c2c(n....
209 1XOT ic50 = 3.8 uM VDN C23 H32 N6 O4 S CCCc1nc(c2....
210 1XLX ic50 = 0.025 uM CIO C20 H25 N O4 COc1ccc(cc....
211 3O57 ic50 = 79.4 pM ZG2 C29 H34 N6 O3 CCn1c2c(cn....
212 3HMV - HBT C17 H17 N3 O4 S C[C@H]1CCc....
213 3O56 ic50 = 794 pM ZG1 C21 H27 N7 O3 CCn1c2c(cn....
214 1XLZ ic50 = 0.96 uM FIL C15 H20 N2 O4 C/C(=NOC(=....
215 1XN0 ic50 = 0.57 uM ROL C16 H21 N O3 COc1ccc(cc....
216 1TB5 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
217 3D3P ic50 = 3.1 nM 20A C21 H25 N5 O2 CCn1c2c(cn....
218 3W5E ic50 = 11 nM NVW C25 H28 N4 O3 S CC(C)(C)NC....
219 4MYQ ic50 = 32 nM 19T C19 H18 Cl N3 O2 S CCc1c(nc(n....
220 2QYL ic50 = 0.65 uM NPV C21 H13 N3 O4 c1cc(cc(c1....
221 1XOS ic50 = 20 uM VIA C22 H30 N6 O4 S CCCc1c2c(n....
222 1XM6 ic50 = 0.42 uM 5RM C14 H19 N O4 CCCOc1cc(c....
223 1RO6 Ki ~ 375 nM ROL C16 H21 N O3 COc1ccc(cc....
224 1Y2H ic50 = 0.056 uM 6DE C14 H15 Cl N2 O2 CCOC(=O)c1....
225 1ROR - AMP C10 H14 N5 O7 P c1nc(c2c(n....
226 5UOY ic50 = 0.027 uM 8HM C24 H27 N5 O3 S COc1ccc(cc....
227 5W6E ic50 = 9.1 nM 0NY C17 H21 N5 O2 Cc1cc([nH]....
228 5B25 Ki = 0.058 nM 4QJ C29 H26 F N7 O CN1C(=O)c2....
229 5UP0 ic50 = 0.46 uM 8HP C18 H15 Cl N4 O S c1cc(ccc1C....
230 3G4G ic50 = 19 nM D71 C19 H13 N5 O4 c1cc(cc(c1....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 4XV; Similar ligands found: 3
No: Ligand ECFP6 Tc MDL keys Tc
1 4XV 1 1
2 4XS 0.588235 0.852941
3 4XY 0.416667 0.75
Similar Ligands (3D)
Ligand no: 1; Ligand: 4XV; Similar ligands found: 1267
No: Ligand Similarity coefficient
1 GDE 0.9802
2 DHK 0.9776
3 BGC 0.9769
4 GCS 0.9758
5 G3F 0.9749
6 QSH 0.9739
7 UFV 0.9701
8 FGZ 0.9682
9 8S0 0.9672
10 7WR 0.9624
11 GAL 0.9618
12 GLC 0.9617
13 GTR 0.9603
14 EVA 0.9596
15 BDP 0.9581
16 DHB 0.9570
17 JTH 0.9562
18 149 0.9518
19 1GN 0.9516
20 CHB 0.9509
21 IHB 0.9508
22 4NC 0.9502
23 GCB 0.9494
24 QSB 0.9492
25 4FH 0.9490
26 INO 0.9483
27 3MG 0.9479
28 X0V 0.9470
29 JLZ 0.9465
30 34D 0.9463
31 GCU 0.9462
32 LGC 0.9461
33 MBG 0.9454
34 P9P 0.9450
35 9TW 0.9446
36 93K 0.9445
37 SKM 0.9443
38 2FG 0.9442
39 2HO 0.9442
40 LDP 0.9441
41 2H5 0.9440
42 YIO 0.9437
43 NNO 0.9434
44 GIV 0.9431
45 ORO 0.9423
46 FA3 0.9420
47 NOJ 0.9420
48 V55 0.9419
49 AS3 0.9416
50 MYJ 0.9414
51 15L 0.9412
52 ADA 0.9412
53 D1X 0.9411
54 EMZ 0.9408
55 4SX 0.9407
56 GLA 0.9403
57 2D0 0.9402
58 S76 0.9400
59 Q88 0.9399
60 4XR 0.9397
61 42J 0.9397
62 DQA 0.9396
63 KOJ 0.9395
64 XX2 0.9392
65 OXC 0.9392
66 FHB 0.9389
67 KBG 0.9387
68 DOR 0.9383
69 X6X 0.9378
70 AW5 0.9375
71 261 0.9374
72 URC 0.9373
73 FP1 0.9372
74 VNL 0.9370
75 OMD 0.9365
76 HX3 0.9362
77 G4D 0.9360
78 4AA 0.9356
79 4A3 0.9353
80 2AL 0.9353
81 ZZ3 0.9353
82 SHG 0.9347
83 DHY 0.9347
84 T6C 0.9345
85 EUG 0.9344
86 AHR 0.9340
87 A7W 0.9337
88 2A7 0.9336
89 LNR 0.9328
90 AX3 0.9324
91 CWM 0.9323
92 IV2 0.9321
93 IFP 0.9321
94 3HM 0.9314
95 MJ2 0.9313
96 8WT 0.9301
97 4M4 0.9301
98 ES0 0.9300
99 EV0 0.9299
100 ZXD 0.9285
101 EKZ 0.9283
102 APZ 0.9281
103 8WO 0.9271
104 GLT 0.9270
105 UAN 0.9263
106 7MH 0.9263
107 CN0 0.9257
108 R9S 0.9255
109 F31 0.9253
110 A13 0.9253
111 AZ9 0.9251
112 57O 0.9249
113 XAZ 0.9248
114 DNC 0.9248
115 4HM 0.9247
116 G2F 0.9247
117 HQD 0.9247
118 JND 0.9247
119 ASC 0.9246
120 ASO 0.9246
121 IAC 0.9246
122 SYA 0.9240
123 EOL 0.9240
124 TBP 0.9238
125 1F1 0.9237
126 0HO 0.9237
127 K3Q 0.9236
128 DEE 0.9234
129 8W9 0.9234
130 IJZ 0.9234
131 PXL 0.9233
132 4ME 0.9231
133 F0J 0.9230
134 LYL 0.9228
135 BNT 0.9227
136 PRZ 0.9226
137 II6 0.9225
138 5WU 0.9224
139 JFJ 0.9224
140 23J 0.9223
141 TSS 0.9223
142 FA6 0.9222
143 DHS 0.9220
144 L99 0.9220
145 2LP 0.9217
146 FDK 0.9217
147 DGJ 0.9216
148 QIC 0.9216
149 UFO 0.9214
150 CWS 0.9211
151 FH2 0.9210
152 FBU 0.9209
153 8TX 0.9206
154 LKA 0.9204
155 ESI 0.9203
156 PAB 0.9203
157 KTA 0.9202
158 DIN 0.9200
159 4CS 0.9200
160 PFB 0.9198
161 FA1 0.9196
162 KT7 0.9196
163 0P6 0.9195
164 0N7 0.9191
165 R9Y 0.9190
166 XIY 0.9190
167 SVD 0.9189
168 PHB 0.9188
169 2A9 0.9187
170 SKA 0.9186
171 GXL 0.9185
172 3AL 0.9182
173 6OT 0.9181
174 HBA 0.9181
175 SHA 0.9178
176 IF7 0.9177
177 BTY 0.9177
178 J9Q 0.9177
179 PZI 0.9176
180 SOR 0.9174
181 35C 0.9174
182 0HN 0.9174
183 OVV 0.9173
184 AEH 0.9171
185 FDB 0.9171
186 QX2 0.9171
187 H7Y 0.9170
188 NOY 0.9170
189 3A9 0.9170
190 J9T 0.9169
191 ISD 0.9168
192 C2U 0.9166
193 7N0 0.9165
194 QPR 0.9165
195 FA0 0.9164
196 VOH 0.9162
197 3HB 0.9162
198 3XX 0.9162
199 SOE 0.9162
200 4FA 0.9161
201 52C 0.9160
202 LCN 0.9158
203 EGR 0.9158
204 3IT 0.9158
205 FOT 0.9157
206 3C4 0.9157
207 B55 0.9155
208 9KH 0.9155
209 6VD 0.9153
210 5QX 0.9152
211 QBK 0.9151
212 5CU 0.9151
213 R8V 0.9150
214 4M0 0.9150
215 DOB 0.9150
216 XAN 0.9150
217 GAF 0.9149
218 Q6T 0.9148
219 97T 0.9148
220 94B 0.9145
221 IFL 0.9145
222 MRW 0.9145
223 AEF 0.9145
224 KTW 0.9144
225 5JQ 0.9143
226 F69 0.9142
227 E7Z 0.9142
228 5OB 0.9142
229 0F9 0.9141
230 NPO 0.9140
231 NVU 0.9139
232 VXX 0.9138
233 KYA 0.9137
234 QWW 0.9136
235 3NY 0.9136
236 5NU 0.9134
237 7W1 0.9134
238 2ZM 0.9134
239 GAB 0.9134
240 HQJ 0.9134
241 NGO 0.9132
242 TTL 0.9132
243 5NI 0.9129
244 HQT 0.9128
245 B2J 0.9127
246 DBH 0.9125
247 3HA 0.9122
248 BZ2 0.9122
249 MR1 0.9121
250 12Q 0.9121
251 6NT 0.9120
252 1M2 0.9119
253 ZWZ 0.9117
254 HJP 0.9116
255 AKH 0.9116
256 GUN 0.9115
257 3DO 0.9112
258 9DG 0.9112
259 FBW 0.9111
260 ICO 0.9111
261 5XC 0.9110
262 B57 0.9110
263 3AB 0.9106
264 717 0.9103
265 75K 0.9102
266 KJH 0.9102
267 1XM 0.9102
268 WOO 0.9101
269 TWO 0.9101
270 8ZE 0.9099
271 JR2 0.9099
272 UEG 0.9098
273 TSR 0.9096
274 BZ3 0.9096
275 61M 0.9094
276 JIF 0.9093
277 B53 0.9093
278 I3A 0.9093
279 AMG 0.9092
280 BEA 0.9092
281 NBG 0.9090
282 8CM 0.9089
283 67N 0.9089
284 ICB 0.9088
285 SJ5 0.9087
286 53C 0.9087
287 L7T 0.9087
288 ABI 0.9087
289 DX4 0.9085
290 EXD 0.9084
291 6FZ 0.9084
292 2EC 0.9084
293 YRL 0.9084
294 3Z8 0.9083
295 HH5 0.9083
296 23A 0.9081
297 OHP 0.9081
298 5RO 0.9079
299 TSU 0.9079
300 0CU 0.9078
301 ONR 0.9078
302 3NT 0.9078
303 82I 0.9075
304 KGK 0.9075
305 MAN 0.9075
306 CXF 0.9075
307 6NI 0.9075
308 G6D 0.9075
309 KUF 0.9074
310 PBZ 0.9074
311 GZL 0.9073
312 42C 0.9073
313 3F0 0.9073
314 4HP 0.9073
315 141 0.9072
316 GOX 0.9071
317 IFM 0.9071
318 M1Q 0.9070
319 LZM 0.9070
320 DNF 0.9070
321 3HP 0.9070
322 SYR 0.9069
323 7D2 0.9068
324 N8Y 0.9068
325 N2Z 0.9068
326 HKD 0.9067
327 P72 0.9067
328 Z5P 0.9066
329 BMA 0.9066
330 8NX 0.9066
331 K32 0.9066
332 ALL 0.9065
333 4ZA 0.9064
334 86J 0.9062
335 5JL 0.9062
336 BHA 0.9062
337 AC6 0.9062
338 0W1 0.9062
339 0FK 0.9060
340 069 0.9060
341 A2F 0.9060
342 4P5 0.9059
343 KIB 0.9059
344 4VP 0.9058
345 HBD 0.9058
346 GTQ 0.9058
347 DIU 0.9057
348 AMH 0.9057
349 3MB 0.9057
350 4J8 0.9056
351 4Z4 0.9055
352 DFB 0.9053
353 XM0 0.9053
354 P3K 0.9052
355 12M 0.9052
356 M5H 0.9050
357 GTL 0.9050
358 4MA 0.9050
359 PHU 0.9046
360 3BZ 0.9046
361 AZA 0.9043
362 209 0.9040
363 FUL 0.9040
364 SWA 0.9039
365 PH2 0.9039
366 4KL 0.9039
367 BSX 0.9037
368 GLF 0.9037
369 L5V 0.9036
370 AIN 0.9034
371 DHR 0.9034
372 1Y6 0.9034
373 BRT 0.9034
374 7NI 0.9033
375 GJZ 0.9033
376 8U3 0.9033
377 8GK 0.9033
378 PA1 0.9032
379 P84 0.9031
380 SAN 0.9031
381 RIB 0.9030
382 MAJ 0.9030
383 TYL 0.9030
384 OXZ 0.9029
385 NTZ 0.9029
386 XXG 0.9028
387 5RN 0.9027
388 6AP 0.9026
389 NIZ 0.9025
390 0JD 0.9024
391 HNQ 0.9023
392 2BG 0.9022
393 42A 0.9022
394 P7Y 0.9021
395 2HC 0.9020
396 9PY 0.9020
397 UNC 0.9020
398 HA5 0.9018
399 NFM 0.9018
400 GF4 0.9018
401 60Q 0.9017
402 6RQ 0.9017
403 K2T 0.9017
404 2CZ 0.9016
405 24W 0.9015
406 4WL 0.9015
407 1P8 0.9015
408 AJ2 0.9014
409 RM1 0.9013
410 5RG 0.9013
411 7MU 0.9012
412 K5W 0.9011
413 QY9 0.9010
414 Z82 0.9010
415 92K 0.9009
416 MT0 0.9009
417 YH7 0.9006
418 O2A 0.9006
419 3OC 0.9006
420 C2Y 0.9006
421 G1P 0.9006
422 AY4 0.9005
423 RBJ 0.9005
424 2HQ 0.9004
425 FBS 0.9004
426 15N 0.9003
427 3M0 0.9003
428 FHN 0.9002
429 AFR 0.9001
430 5WY 0.9001
431 4HC 0.9001
432 KKN 0.9001
433 N2I 0.9000
434 WCE 0.8999
435 SBK 0.8998
436 JDN 0.8998
437 H8N 0.8997
438 1LQ 0.8997
439 GYE 0.8996
440 FBB 0.8996
441 RSO 0.8996
442 948 0.8995
443 03V 0.8995
444 JZ4 0.8994
445 AMS 0.8994
446 COU 0.8994
447 PAC 0.8993
448 BCP 0.8993
449 XX3 0.8992
450 0LH 0.8992
451 495 0.8992
452 ABV 0.8992
453 ESP 0.8992
454 MO8 0.8991
455 PRY 0.8991
456 AX7 0.8991
457 BK9 0.8990
458 BOA 0.8990
459 B62 0.8990
460 5QY 0.8989
461 E35 0.8988
462 INE 0.8988
463 S24 0.8986
464 8XQ 0.8986
465 8IG 0.8986
466 ES2 0.8986
467 54G 0.8985
468 5M0 0.8985
469 SRO 0.8985
470 M1A 0.8984
471 BNF 0.8984
472 ET2 0.8983
473 M1E 0.8982
474 FE DB1 0.8980
475 3R6 0.8979
476 H33 0.8979
477 CTS 0.8978
478 45L 0.8978
479 ISZ 0.8977
480 BCU 0.8976
481 6DP 0.8976
482 APS 0.8975
483 CFI 0.8974
484 N5J 0.8973
485 JFD 0.8972
486 RAT 0.8972
487 270 0.8972
488 2HU 0.8972
489 JZ3 0.8972
490 ZZ8 0.8971
491 9ZE 0.8971
492 1SQ 0.8971
493 3RI 0.8970
494 7VS 0.8970
495 4FS 0.8970
496 NMJ 0.8970
497 ANN 0.8970
498 36E 0.8969
499 HDH 0.8968
500 0W8 0.8967
501 SR1 0.8966
502 M5K 0.8966
503 3DM 0.8966
504 F9Y 0.8965
505 51R 0.8965
506 SW7 0.8965
507 92P 0.8965
508 M2K 0.8965
509 8GC 0.8964
510 6CS 0.8964
511 263 0.8963
512 RNS 0.8963
513 IGA 0.8963
514 IOS 0.8960
515 KJY 0.8960
516 M6N 0.8960
517 XCZ 0.8959
518 7HQ 0.8959
519 J9W 0.8959
520 2MI 0.8958
521 3FH 0.8958
522 FCR 0.8957
523 MEW 0.8957
524 JB5 0.8957
525 KIA 0.8956
526 NDM 0.8956
527 GIF 0.8955
528 MQB 0.8955
529 4MU 0.8955
530 2AQ 0.8955
531 505 0.8953
532 6GU 0.8953
533 2LY 0.8952
534 3PF 0.8952
535 7B4 0.8952
536 9TZ 0.8951
537 N7I 0.8951
538 3Z7 0.8951
539 39O 0.8950
540 XQ0 0.8949
541 9MG 0.8949
542 3ID 0.8948
543 FBA 0.8948
544 1XA 0.8948
545 F12 0.8948
546 DBJ 0.8947
547 AEG 0.8947
548 Q24 0.8946
549 5WV 0.8946
550 GV9 0.8946
551 JB8 0.8945
552 CKU 0.8944
553 FAN 0.8944
554 AZG 0.8944
555 OTW 0.8944
556 C2B 0.8944
557 XQI 0.8943
558 9FE 0.8943
559 KP6 0.8942
560 ES5 0.8942
561 CXH 0.8942
562 0FN 0.8941
563 MS9 0.8941
564 HY1 0.8940
565 FCB 0.8940
566 5SG 0.8940
567 VGD 0.8940
568 HPA 0.8940
569 PNZ 0.8940
570 2PG 0.8939
571 OTR 0.8939
572 CLW 0.8939
573 XXR 0.8938
574 FBM 0.8938
575 C9E 0.8937
576 4ZC 0.8937
577 LAO 0.8936
578 AH8 0.8936
579 C2A 0.8936
580 E7S 0.8935
581 AZ8 0.8934
582 KBB 0.8934
583 36R 0.8932
584 4JL 0.8932
585 IPZ 0.8932
586 6XI 0.8931
587 ARP 0.8931
588 5HN 0.8930
589 8H8 0.8930
590 7ME 0.8929
591 1P7 0.8929
592 DRL 0.8928
593 JKZ 0.8928
594 FYU 0.8928
595 M3H 0.8927
596 BHO 0.8926
597 TFU 0.8925
598 PEA 0.8925
599 P92 0.8924
600 293 0.8924
601 AQO 0.8923
602 XQG 0.8923
603 NAG 0.8923
604 PEL 0.8923
605 AAS 0.8922
606 1NP 0.8921
607 ES1 0.8920
608 XHP 0.8919
609 K22 0.8918
610 2O6 0.8918
611 5IQ 0.8917
612 ODO 0.8916
613 HHA 0.8915
614 GLU 0.8915
615 8NB 0.8913
616 CFP 0.8913
617 RHU 0.8913
618 5Q0 0.8912
619 290 0.8911
620 ISN 0.8911
621 JPZ 0.8911
622 M1H 0.8911
623 TTY 0.8910
624 1P3 0.8910
625 JBK 0.8910
626 HHT 0.8910
627 ES7 0.8909
628 OCH 0.8909
629 NQH 0.8909
630 DMJ 0.8907
631 268 0.8907
632 4YS 0.8907
633 PE0 0.8907
634 EXO 0.8907
635 1XN 0.8906
636 MNM 0.8905
637 H5B 0.8905
638 R8S 0.8905
639 12T 0.8905
640 173 0.8905
641 6TZ 0.8904
642 DQU 0.8904
643 HLD 0.8904
644 4JQ 0.8904
645 EDR 0.8903
646 HDL 0.8903
647 TPA 0.8903
648 4XH 0.8902
649 AGK 0.8901
650 6LW 0.8900
651 9KT 0.8899
652 JBH 0.8898
653 VK3 0.8898
654 5NS 0.8898
655 H42 0.8897
656 DMD 0.8896
657 2FQ 0.8896
658 NLA 0.8896
659 0FO 0.8896
660 5NE 0.8895
661 LT2 0.8895
662 HZQ 0.8894
663 M0W 0.8894
664 RM4 0.8893
665 TEP 0.8893
666 FRU 0.8893
667 OW4 0.8892
668 DIE 0.8892
669 OVM 0.8891
670 2ZQ 0.8891
671 HMH 0.8891
672 CBF 0.8890
673 URS 0.8890
674 NSP 0.8890
675 5MK 0.8889
676 FUC 0.8889
677 7W4 0.8889
678 HQY 0.8888
679 MFB 0.8887
680 LI6 0.8886
681 O72 0.8885
682 5VM 0.8885
683 ORN 0.8885
684 K17 0.8885
685 HMU 0.8885
686 F81 0.8883
687 NDG 0.8883
688 YTX 0.8882
689 BPN 0.8882
690 25W 0.8882
691 G3E 0.8881
692 826 0.8881
693 J5I 0.8881
694 ZB1 0.8881
695 QX4 0.8881
696 ESX 0.8879
697 1LM 0.8878
698 7VJ 0.8877
699 HH8 0.8877
700 EA1 0.8876
701 5OF 0.8875
702 BE2 0.8875
703 IBM 0.8875
704 RXA 0.8872
705 BDF 0.8872
706 SX1 0.8871
707 H76 0.8871
708 CFF 0.8871
709 SAL 0.8871
710 1AL 0.8870
711 GLY PRO 0.8870
712 174 0.8870
713 PQ0 0.8870
714 XYP 0.8870
715 UNJ 0.8870
716 SXS 0.8868
717 M0Q 0.8868
718 GM7 0.8867
719 GJS 0.8867
720 QMP 0.8867
721 N3W 0.8867
722 2F6 0.8866
723 GXY 0.8866
724 BZX 0.8866
725 329 0.8865
726 44V 0.8865
727 OGA 0.8864
728 6ME 0.8863
729 9FL 0.8863
730 NID 0.8862
731 0GZ 0.8862
732 G5V 0.8861
733 IPB 0.8861
734 CFA 0.8860
735 R20 0.8860
736 D48 0.8860
737 TIU 0.8860
738 MSR 0.8859
739 PO6 0.8858
740 2FY 0.8858
741 2D3 0.8858
742 OKM 0.8857
743 PBC 0.8857
744 J6W 0.8856
745 M1Z 0.8855
746 PDC 0.8854
747 CLZ 0.8853
748 SE2 0.8852
749 NK 0.8851
750 M4E 0.8850
751 MUA 0.8850
752 MMA 0.8850
753 4YO 0.8850
754 XDE 0.8849
755 ALE 0.8849
756 BEZ 0.8849
757 HXX 0.8849
758 MNP 0.8849
759 QAT 0.8847
760 5JC 0.8847
761 428 0.8847
762 HHR 0.8846
763 CPZ 0.8846
764 H4E 0.8845
765 RB5 0.8845
766 44W 0.8845
767 MZG 0.8844
768 JKE 0.8843
769 4TU 0.8843
770 HA7 0.8842
771 F9P 0.8842
772 39A 0.8842
773 94W 0.8841
774 LIP 0.8841
775 7ZE 0.8841
776 2GS 0.8840
777 H6B 0.8840
778 LRH 0.8839
779 GDL 0.8839
780 D07 0.8839
781 4CL 0.8838
782 MA3 0.8838
783 NQ 0.8837
784 E1T 0.8837
785 SMN 0.8837
786 5WX 0.8837
787 HLZ 0.8836
788 LT8 0.8836
789 SRT 0.8835
790 0R0 0.8835
791 TH7 0.8835
792 KJ5 0.8834
793 X05 0.8833
794 8HC 0.8832
795 XQK 0.8832
796 24B 0.8832
797 XUL 0.8831
798 S2G 0.8831
799 GOG 0.8831
800 7MX 0.8831
801 2SX 0.8831
802 PZM 0.8831
803 I1E 0.8831
804 MCT 0.8830
805 HQ9 0.8830
806 BR9 0.8829
807 BNS 0.8828
808 PD2 0.8828
809 HPT 0.8827
810 AKG 0.8827
811 TZE 0.8826
812 SWD 0.8826
813 NYL 0.8826
814 BEN 0.8826
815 10L 0.8825
816 680 0.8825
817 FK8 0.8824
818 2BX 0.8824
819 MIG 0.8824
820 MWJ 0.8824
821 4JM 0.8822
822 CTL 0.8822
823 KDV 0.8821
824 5B1 0.8821
825 258 0.8821
826 GJP 0.8820
827 463 0.8820
828 GCO 0.8820
829 BTE 0.8819
830 FEH 0.8818
831 51F 0.8817
832 ZZT 0.8816
833 HIS 0.8816
834 GVG 0.8816
835 NPA 0.8816
836 Y8I 0.8814
837 OA3 0.8813
838 512 0.8813
839 JAW 0.8813
840 KJU 0.8813
841 PRA 0.8813
842 ZYR 0.8813
843 LXC 0.8813
844 M4S 0.8812
845 DPZ 0.8812
846 AMC 0.8812
847 SNO 0.8812
848 YSO 0.8811
849 27Y 0.8810
850 M4T 0.8809
851 JAE 0.8809
852 8XL 0.8809
853 NDH 0.8807
854 EYK 0.8807
855 4BY 0.8807
856 2DR 0.8807
857 2MN 0.8806
858 PRF 0.8806
859 DNA 0.8806
860 4JJ 0.8805
861 MVN 0.8805
862 CH9 0.8805
863 IPD 0.8805
864 UNU 0.8803
865 37T 0.8803
866 9RW 0.8803
867 4RU 0.8802
868 FDR 0.8802
869 5LA 0.8800
870 MSN 0.8799
871 VNJ 0.8799
872 FBV 0.8798
873 GIO 0.8797
874 NCA 0.8796
875 BAM 0.8796
876 X09 0.8795
877 6PC 0.8795
878 OTD 0.8795
879 MQN 0.8794
880 F4E 0.8793
881 ES4 0.8793
882 ADE 0.8792
883 3SK 0.8792
884 DBX 0.8791
885 2K8 0.8791
886 SLS 0.8790
887 LZ2 0.8789
888 2YU 0.8789
889 4HO 0.8789
890 MT5 0.8788
891 CKX 0.8788
892 TOF 0.8788
893 7HP 0.8788
894 GLN 0.8787
895 KG1 0.8787
896 QOS 0.8787
897 FUF 0.8786
898 4JT 0.8786
899 GWM 0.8786
900 14O 0.8786
901 3U4 0.8786
902 SN4 0.8785
903 URF 0.8785
904 NIO 0.8785
905 AL0 0.8783
906 1X7 0.8782
907 V1T 0.8781
908 QMS 0.8781
909 LSA 0.8781
910 PIM 0.8780
911 GCW 0.8779
912 12B 0.8779
913 6MP 0.8779
914 MFU 0.8778
915 9R5 0.8777
916 3ZB 0.8777
917 PXM 0.8776
918 5H1 0.8776
919 286 0.8776
920 2CL 0.8776
921 HHH 0.8775
922 1HN 0.8775
923 2AC 0.8775
924 TGX 0.8775
925 AZF 0.8772
926 TRC 0.8772
927 JZ2 0.8772
928 QBM 0.8771
929 DGL 0.8770
930 2IT 0.8770
931 2K4 0.8770
932 F5B 0.8770
933 TBS 0.8768
934 0TU 0.8768
935 J0Z 0.8767
936 PHH 0.8767
937 M3Q 0.8767
938 6AI 0.8766
939 ISE 0.8765
940 GZ8 0.8764
941 A29 0.8763
942 PYD 0.8763
943 QSC 0.8762
944 9DA 0.8762
945 RNO 0.8762
946 7WG 0.8762
947 FB1 0.8762
948 QXW 0.8761
949 GTZ 0.8761
950 49O 0.8761
951 A9O 0.8761
952 6R8 0.8760
953 7WA 0.8760
954 RMN 0.8760
955 XYD 0.8759
956 2HG 0.8759
957 DA4 0.8759
958 DC5 0.8759
959 NBZ 0.8759
960 2MP 0.8758
961 A1U 0.8758
962 1DW 0.8758
963 PYQ 0.8758
964 5MI 0.8757
965 MPK 0.8756
966 SG2 0.8756
967 GGL 0.8756
968 ZZZ 0.8755
969 4SV 0.8755
970 1MC 0.8755
971 MXD 0.8754
972 9HX 0.8754
973 ADZ 0.8754
974 692 0.8753
975 XBZ 0.8753
976 TRA 0.8753
977 PM6 0.8753
978 PZA 0.8753
979 GYP 0.8752
980 8OZ 0.8752
981 STT 0.8752
982 QAS 0.8751
983 34A 0.8751
984 HT4 0.8751
985 ASP 0.8751
986 NIG 0.8750
987 HPS 0.8749
988 TQU 0.8749
989 ES6 0.8749
990 7I2 0.8749
991 IP0 0.8748
992 4NM 0.8747
993 WBU 0.8747
994 JRB 0.8746
995 2AK 0.8746
996 TH0 0.8745
997 HC4 0.8745
998 BP1 0.8744
999 I4D 0.8743
1000 F6P 0.8743
1001 QUS 0.8743
1002 OVP 0.8743
1003 EVF 0.8742
1004 4JC 0.8741
1005 R2B 0.8740
1006 HSX 0.8740
1007 CWJ 0.8740
1008 2KA 0.8740
1009 BPY 0.8740
1010 4BZ 0.8740
1011 I6G 0.8740
1012 SYN 0.8739
1013 ZON 0.8738
1014 CIY 0.8738
1015 4ZE 0.8737
1016 YO5 0.8736
1017 MWP 0.8736
1018 JG8 0.8734
1019 SYV 0.8733
1020 MWM 0.8733
1021 4JO 0.8733
1022 F60 0.8732
1023 PMB 0.8732
1024 4AV 0.8730
1025 NTN 0.8730
1026 TM7 0.8729
1027 ES9 0.8729
1028 6KT 0.8729
1029 AVI 0.8728
1030 YQA 0.8728
1031 5MB 0.8728
1032 E5X 0.8728
1033 11S 0.8728
1034 7WV 0.8728
1035 27B 0.8727
1036 61O 0.8726
1037 HCI 0.8726
1038 YCP 0.8726
1039 TT4 0.8725
1040 SS1 0.8725
1041 A9P 0.8723
1042 CR1 0.8723
1043 1PT 0.8723
1044 43M 0.8722
1045 PFL 0.8722
1046 5GU 0.8720
1047 FPI 0.8719
1048 FB2 0.8718
1049 ABF 0.8718
1050 5MH 0.8717
1051 1QP 0.8716
1052 FLC 0.8715
1053 L46 0.8714
1054 449 0.8714
1055 AOS 0.8713
1056 OW7 0.8713
1057 1A7 0.8713
1058 264 0.8712
1059 JF1 0.8712
1060 PIY 0.8712
1061 1WD 0.8712
1062 68A 0.8711
1063 5ZE 0.8710
1064 JF6 0.8709
1065 1U6 0.8709
1066 LDR 0.8708
1067 NCD 0.8707
1068 INS 0.8707
1069 PJW 0.8707
1070 SEP 0.8705
1071 271 0.8704
1072 PYF 0.8702
1073 V6F 0.8702
1074 LYS 0.8700
1075 2ZX 0.8699
1076 GNM 0.8698
1077 SS2 0.8698
1078 TAG 0.8697
1079 OAA 0.8696
1080 TLD 0.8695
1081 95Z 0.8695
1082 ICP 0.8695
1083 6M4 0.8695
1084 AC0 0.8693
1085 HBX 0.8693
1086 R2P 0.8691
1087 SKF 0.8691
1088 KDF 0.8691
1089 ERH 0.8690
1090 275 0.8689
1091 NTM 0.8689
1092 ADK 0.8688
1093 GOO 0.8687
1094 TDR 0.8687
1095 36Y 0.8687
1096 HBO 0.8686