Receptor
PDB id Resolution Class Description Source Keywords
5C4L 2.35 Å NON-ENZYME: OTHER CONFORMATIONAL ALTERNATE OF SISOMICIN IN COMPLEX WITH APH(2" ENTEROCOCCUS CASSELIFLAVUS AMINOGLYCOSIDE PHOSPHOTRANSFERASE ANTIBIOTIC RESISTANCE TR
Ref.: AMINOGLYCOSIDE BINDING AND CATALYSIS SPECIFICITY OF AMINOGLYCOSIDE 2-PHOSPHOTRANSFERASE IVA: A THERMODY STRUCTURAL AND KINETIC STUDY. BIOCHIM.BIOPHYS.ACTA V.1860 802 2016
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
4XR A:401;
Valid;
none;
submit data
144.172 C6 H12 N2 O2 C1C=C...
SIS B:401;
Valid;
none;
Kd = 2.3 uM
447.526 C19 H37 N5 O7 C[C@@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5C4L 2.35 Å NON-ENZYME: OTHER CONFORMATIONAL ALTERNATE OF SISOMICIN IN COMPLEX WITH APH(2" ENTEROCOCCUS CASSELIFLAVUS AMINOGLYCOSIDE PHOSPHOTRANSFERASE ANTIBIOTIC RESISTANCE TR
Ref.: AMINOGLYCOSIDE BINDING AND CATALYSIS SPECIFICITY OF AMINOGLYCOSIDE 2-PHOSPHOTRANSFERASE IVA: A THERMODY STRUCTURAL AND KINETIC STUDY. BIOCHIM.BIOPHYS.ACTA V.1860 802 2016
Members (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 3SG8 - TOY C18 H37 N5 O9 C1[C@@H]([....
2 4DTA - ADN C10 H13 N5 O4 c1nc(c2c(n....
3 4DT8 - ADN C10 H13 N5 O4 c1nc(c2c(n....
4 3SG9 - KAN C18 H36 N4 O11 C1[C@H]([C....
5 4DT9 - GMP C10 H13 N5 O5 c1nc2c(n1[....
6 6CD7 - EDS C25 H48 N6 O10 C[C@@]1(CO....
7 5C4L Kd = 2.3 uM SIS C19 H37 N5 O7 C[C@@]1(CO....
8 4DTB - GMP C10 H13 N5 O5 c1nc2c(n1[....
70% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 3SG8 - TOY C18 H37 N5 O9 C1[C@@H]([....
2 4DTA - ADN C10 H13 N5 O4 c1nc(c2c(n....
3 4DT8 - ADN C10 H13 N5 O4 c1nc(c2c(n....
4 3SG9 - KAN C18 H36 N4 O11 C1[C@H]([C....
5 4DT9 - GMP C10 H13 N5 O5 c1nc2c(n1[....
6 6CD7 - EDS C25 H48 N6 O10 C[C@@]1(CO....
7 5C4L Kd = 2.3 uM SIS C19 H37 N5 O7 C[C@@]1(CO....
8 4DTB - GMP C10 H13 N5 O5 c1nc2c(n1[....
50% Homology Family (8)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 3SG8 - TOY C18 H37 N5 O9 C1[C@@H]([....
2 4DTA - ADN C10 H13 N5 O4 c1nc(c2c(n....
3 4DT8 - ADN C10 H13 N5 O4 c1nc(c2c(n....
4 3SG9 - KAN C18 H36 N4 O11 C1[C@H]([C....
5 4DT9 - GMP C10 H13 N5 O5 c1nc2c(n1[....
6 6CD7 - EDS C25 H48 N6 O10 C[C@@]1(CO....
7 5C4L Kd = 2.3 uM SIS C19 H37 N5 O7 C[C@@]1(CO....
8 4DTB - GMP C10 H13 N5 O5 c1nc2c(n1[....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 4XR; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 4XR 1 1
Ligand no: 2; Ligand: SIS; Similar ligands found: 7
No: Ligand ECFP6 Tc MDL keys Tc
1 SIS 1 1
2 DVM 0.759036 0.916667
3 827 0.576471 0.910714
4 LLL 0.576471 0.946429
5 GET 0.563218 0.859649
6 51G 0.545455 0.844828
7 EDS 0.522936 0.873016
Similar Ligands (3D)
Ligand no: 1; Ligand: 4XR; Similar ligands found: 1293
No: Ligand Similarity coefficient
1 KOJ 0.9846
2 4HO 0.9823
3 XBZ 0.9822
4 MCT 0.9812
5 5JC 0.9811
6 2AC 0.9792
7 A1U 0.9786
8 HX3 0.9784
9 4ZE 0.9779
10 MZG 0.9779
11 HBA 0.9779
12 URF 0.9773
13 275 0.9772
14 34A 0.9772
15 WBU 0.9770
16 TDR 0.9768
17 4JJ 0.9760
18 ICP 0.9760
19 JZ2 0.9758
20 XYD 0.9757
21 MWM 0.9757
22 TH0 0.9757
23 2MP 0.9754
24 4CL 0.9751
25 1MC 0.9750
26 2YU 0.9747
27 BR9 0.9747
28 HT4 0.9746
29 5MH 0.9744
30 QOS 0.9742
31 5UC 0.9741
32 MWJ 0.9730
33 27Y 0.9730
34 DHB 0.9728
35 PYD 0.9724
36 TM7 0.9716
37 P9P 0.9715
38 43M 0.9697
39 4A3 0.9688
40 PHB 0.9680
41 9TW 0.9674
42 4JO 0.9671
43 FHB 0.9670
44 MYJ 0.9668
45 4NC 0.9660
46 XX2 0.9660
47 LDU 0.9660
48 4VP 0.9653
49 2MI 0.9651
50 93K 0.9651
51 AX7 0.9643
52 Y8I 0.9642
53 CWM 0.9642
54 270 0.9639
55 2HO 0.9636
56 3HM 0.9634
57 TLD 0.9629
58 JLZ 0.9623
59 NNO 0.9622
60 1DW 0.9616
61 ES0 0.9613
62 ABV 0.9609
63 CHB 0.9603
64 BZX 0.9601
65 Q88 0.9600
66 NK 0.9598
67 IUR 0.9597
68 RIB 0.9596
69 INO 0.9593
70 HMH 0.9581
71 FYU 0.9564
72 6AI 0.9562
73 TH7 0.9553
74 H8N 0.9544
75 0R0 0.9538
76 GAB 0.9538
77 V55 0.9536
78 MAN 0.9536
79 QSB 0.9535
80 AHR 0.9535
81 IF7 0.9533
82 4JL 0.9530
83 5XC 0.9527
84 82I 0.9526
85 GAL 0.9526
86 14O 0.9525
87 IFL 0.9525
88 IHB 0.9523
89 F0J 0.9522
90 8H8 0.9519
91 3ID 0.9517
92 EUG 0.9512
93 5H1 0.9510
94 SYN 0.9510
95 F60 0.9508
96 M1A 0.9508
97 DMD 0.9508
98 5MB 0.9497
99 5MI 0.9494
100 XYP 0.9494
101 HBX 0.9490
102 T6C 0.9489
103 DGJ 0.9486
104 23A 0.9481
105 4JM 0.9480
106 PAB 0.9479
107 ET2 0.9476
108 282 0.9475
109 KKN 0.9474
110 2A9 0.9474
111 2K4 0.9473
112 67N 0.9469
113 2D0 0.9469
114 XQ0 0.9467
115 11S 0.9466
116 3HB 0.9464
117 CLW 0.9463
118 7W4 0.9462
119 5OB 0.9461
120 ES7 0.9461
121 ES9 0.9461
122 3XX 0.9460
123 BZ3 0.9458
124 5WV 0.9457
125 03V 0.9456
126 PYF 0.9455
127 C2B 0.9454
128 BSX 0.9451
129 ADE 0.9447
130 GLC 0.9447
131 717 0.9445
132 1Y6 0.9444
133 36R 0.9444
134 JB5 0.9443
135 AMC 0.9442
136 53C 0.9441
137 4FS 0.9441
138 MLT 0.9439
139 7HQ 0.9436
140 NPO 0.9435
141 0MK 0.9434
142 4M4 0.9432
143 ES5 0.9432
144 H4N 0.9431
145 ES2 0.9430
146 LZ1 0.9430
147 FBB 0.9429
148 FP1 0.9429
149 ABN 0.9429
150 5VM 0.9428
151 K2T 0.9424
152 FPI 0.9422
153 1P8 0.9421
154 AC6 0.9421
155 4CS 0.9421
156 1M2 0.9420
157 HPA 0.9419
158 FK1 0.9419
159 P3K 0.9417
160 0R1 0.9417
161 2AQ 0.9417
162 XIY 0.9417
163 ISN 0.9415
164 10L 0.9413
165 JIF 0.9412
166 DEN 0.9412
167 IND 0.9410
168 9DA 0.9408
169 150 0.9407
170 BML 0.9406
171 F81 0.9405
172 MNM 0.9405
173 5HN 0.9404
174 Z82 0.9402
175 I3A 0.9398
176 4CH 0.9398
177 4XV 0.9397
178 1WG 0.9397
179 FBA 0.9397
180 ZZT 0.9394
181 GVH 0.9392
182 LDP 0.9390
183 CRS 0.9390
184 EDG 0.9389
185 4JP 0.9388
186 OVV 0.9387
187 HMU 0.9386
188 MPI 0.9386
189 VNL 0.9386
190 4ZC 0.9384
191 BZF 0.9380
192 QUZ 0.9380
193 NOJ 0.9380
194 5NU 0.9379
195 24B 0.9379
196 COU 0.9375
197 OCH 0.9375
198 1SQ 0.9375
199 G4D 0.9375
200 CXF 0.9375
201 LXC 0.9374
202 5SG 0.9373
203 2MH 0.9373
204 4JN 0.9372
205 2CQ 0.9371
206 9HX 0.9371
207 BZI 0.9370
208 2XX 0.9369
209 NSP 0.9369
210 3Z7 0.9369
211 FAN 0.9367
212 DOB 0.9367
213 BVF 0.9367
214 PY7 0.9367
215 DMJ 0.9367
216 3AB 0.9366
217 3NT 0.9366
218 4HM 0.9366
219 RCO 0.9365
220 H42 0.9365
221 FA0 0.9364
222 1P7 0.9364
223 3CH 0.9363
224 M3T 0.9363
225 4HS 0.9363
226 GLU 0.9363
227 PXY 0.9361
228 1LQ 0.9361
229 BHA 0.9361
230 7HP 0.9360
231 4XS 0.9360
232 P72 0.9360
233 5CU 0.9359
234 5IQ 0.9359
235 NPY 0.9358
236 NBE 0.9357
237 4YS 0.9357
238 FPY 0.9356
239 DHK 0.9356
240 PBZ 0.9356
241 4AA 0.9355
242 LG5 0.9355
243 JPZ 0.9354
244 8GF 0.9352
245 JBH 0.9352
246 N5J 0.9351
247 7WA 0.9350
248 PCR 0.9350
249 5Q0 0.9350
250 YRL 0.9349
251 9EW 0.9348
252 3DM 0.9348
253 HQY 0.9347
254 O72 0.9347
255 ES1 0.9345
256 7MH 0.9345
257 9X7 0.9344
258 1LM 0.9343
259 CIG 0.9343
260 LG4 0.9341
261 LG3 0.9341
262 4MA 0.9341
263 1NP 0.9340
264 LCN 0.9339
265 6MP 0.9338
266 AEF 0.9338
267 VNJ 0.9337
268 E7Z 0.9337
269 3OC 0.9337
270 4M0 0.9336
271 1MR 0.9336
272 BEZ 0.9334
273 HLR 0.9333
274 25R 0.9332
275 JZ3 0.9331
276 JFD 0.9330
277 HGQ 0.9330
278 HQE 0.9329
279 6PC 0.9329
280 HBD 0.9328
281 826 0.9328
282 A7W 0.9327
283 45C 0.9327
284 6RQ 0.9326
285 FPN 0.9326
286 URA 0.9326
287 TC7 0.9326
288 PLQ 0.9325
289 DA1 0.9325
290 26D 0.9324
291 DBH 0.9323
292 HEW 0.9323
293 3U4 0.9323
294 R8S 0.9321
295 PCA 0.9321
296 174 0.9319
297 6M9 0.9318
298 FE DB1 0.9317
299 IDH 0.9316
300 IFP 0.9315
301 RBJ 0.9315
302 GIF 0.9314
303 DFU 0.9314
304 BGC 0.9314
305 3HA 0.9313
306 SAL 0.9310
307 IDM 0.9310
308 F9Y 0.9310
309 4JU 0.9310
310 8NY 0.9308
311 3F0 0.9308
312 ASP 0.9308
313 4H2 0.9306
314 BEN 0.9305
315 0RW 0.9305
316 FCA 0.9305
317 3M0 0.9305
318 C2A 0.9304
319 4FA 0.9304
320 GLA 0.9303
321 BE2 0.9302
322 WCE 0.9301
323 B3R 0.9300
324 GXL 0.9300
325 IOL 0.9298
326 2LP 0.9298
327 SKM 0.9298
328 EKZ 0.9297
329 0CT 0.9297
330 32O 0.9297
331 42J 0.9296
332 3BZ 0.9294
333 2H5 0.9294
334 3DO 0.9292
335 2A7 0.9292
336 GDE 0.9292
337 CYT 0.9291
338 XRG 0.9290
339 DIN 0.9290
340 F05 0.9290
341 2BG 0.9289
342 FUL 0.9287
343 5B1 0.9287
344 RIP 0.9282
345 ASO 0.9281
346 BTE 0.9280
347 SVN 0.9278
348 4SV 0.9276
349 ES6 0.9275
350 G2F 0.9274
351 75K 0.9274
352 7A8 0.9273
353 MRW 0.9273
354 HHQ 0.9273
355 DHS 0.9272
356 PM6 0.9271
357 S76 0.9271
358 SW7 0.9271
359 FDB 0.9270
360 35C 0.9270
361 1AB 0.9269
362 8WT 0.9268
363 NIO 0.9265
364 X0V 0.9263
365 R2B 0.9263
366 9CL 0.9262
367 MR1 0.9262
368 PBC 0.9262
369 BMA 0.9261
370 NCA 0.9259
371 F4Z 0.9258
372 AGK 0.9258
373 RSO 0.9258
374 BAM 0.9257
375 TBP 0.9256
376 BDF 0.9256
377 GAF 0.9255
378 MBG 0.9255
379 OXZ 0.9254
380 XAN 0.9254
381 DHR 0.9253
382 BP1 0.9253
383 XUL 0.9253
384 PEL 0.9251
385 ALL 0.9250
386 LMR 0.9250
387 1PT 0.9250
388 24W 0.9248
389 ORN 0.9248
390 NOY 0.9247
391 MZW 0.9245
392 PYJ 0.9244
393 GCS 0.9244
394 5RG 0.9243
395 GTQ 0.9243
396 X6X 0.9242
397 261 0.9241
398 4P5 0.9241
399 54G 0.9240
400 0HO 0.9239
401 1GN 0.9239
402 1F1 0.9238
403 3A9 0.9238
404 URC 0.9238
405 FA1 0.9238
406 8TX 0.9237
407 SOE 0.9237
408 5RO 0.9236
409 2FG 0.9236
410 ES4 0.9235
411 BP9 0.9234
412 5M0 0.9232
413 QSH 0.9231
414 PZM 0.9231
415 4Z4 0.9230
416 R8A 0.9230
417 8WO 0.9229
418 FGZ 0.9228
419 2CK 0.9228
420 UNU 0.9228
421 DFB 0.9228
422 AC0 0.9227
423 F31 0.9226
424 42A 0.9226
425 BRT 0.9226
426 FUC 0.9225
427 HPY 0.9222
428 4XH 0.9220
429 EHM 0.9220
430 G3E 0.9219
431 JZ9 0.9219
432 149 0.9218
433 IV2 0.9216
434 PZI 0.9214
435 4FH 0.9213
436 JAE 0.9212
437 64K 0.9212
438 BTY 0.9210
439 ORO 0.9210
440 CFI 0.9209
441 NBZ 0.9208
442 ABE 0.9207
443 HY1 0.9206
444 ZXD 0.9206
445 LRH 0.9206
446 LZM 0.9205
447 SS1 0.9204
448 NIZ 0.9204
449 0P6 0.9203
450 4ZA 0.9203
451 1P3 0.9202
452 VGL 0.9200
453 KJH 0.9200
454 AZA 0.9200
455 6LW 0.9200
456 PEA 0.9200
457 ISZ 0.9198
458 JA8 0.9198
459 ASN 0.9198
460 WOO 0.9198
461 ADZ 0.9197
462 86J 0.9195
463 7W1 0.9195
464 PZA 0.9194
465 OAA 0.9194
466 PHU 0.9193
467 YCP 0.9193
468 M58 0.9191
469 5JQ 0.9191
470 HH8 0.9190
471 SHA 0.9189
472 J9T 0.9189
473 YH7 0.9188
474 12Q 0.9187
475 5MK 0.9187
476 ZZ3 0.9187
477 FH2 0.9186
478 QSC 0.9186
479 XM0 0.9186
480 VOH 0.9186
481 NMJ 0.9185
482 286 0.9184
483 PA1 0.9184
484 R1X 0.9183
485 5QX 0.9182
486 3SK 0.9181
487 NTN 0.9181
488 VGD 0.9180
489 OHG 0.9180
490 FDK 0.9179
491 JZ7 0.9178
492 8GC 0.9178
493 M4T 0.9177
494 CWS 0.9177
495 BE7 0.9177
496 RM4 0.9177
497 5RN 0.9176
498 45L 0.9176
499 B55 0.9175
500 L99 0.9175
501 Z6J 0.9172
502 H76 0.9172
503 2ZM 0.9172
504 6UA 0.9172
505 J5I 0.9171
506 GLF 0.9171
507 9DG 0.9170
508 B57 0.9168
509 PYG 0.9168
510 JZ4 0.9168
511 SX1 0.9167
512 XAZ 0.9166
513 6GU 0.9166
514 KJY 0.9165
515 SE2 0.9165
516 0HN 0.9165
517 GYE 0.9165
518 IGA 0.9164
519 IFM 0.9164
520 9TZ 0.9164
521 LNR 0.9163
522 J1Z 0.9163
523 7B4 0.9163
524 290 0.9161
525 JKE 0.9161
526 8S0 0.9161
527 APY 0.9161
528 95Z 0.9161
529 FCB 0.9160
530 0TR 0.9160
531 1XM 0.9159
532 GUN 0.9159
533 KUF 0.9158
534 8ZE 0.9156
535 RNS 0.9156
536 D1X 0.9155
537 1WD 0.9155
538 SR1 0.9155
539 N2I 0.9154
540 I1E 0.9154
541 8CM 0.9153
542 BNS 0.9153
543 MS9 0.9153
544 4SX 0.9153
545 2AL 0.9153
546 B24 0.9153
547 ICO 0.9152
548 D48 0.9150
549 6AP 0.9150
550 HYA 0.9149
551 JBK 0.9147
552 B53 0.9145
553 3PF 0.9145
554 QDK 0.9145
555 BDP 0.9145
556 A2F 0.9144
557 5NI 0.9144
558 54D 0.9143
559 CN0 0.9142
560 5JL 0.9142
561 SEJ 0.9142
562 0CU 0.9138
563 AFR 0.9138
564 JBE 0.9135
565 MBD 0.9134
566 AZG 0.9133
567 IPB 0.9133
568 XCZ 0.9133
569 XYS 0.9133
570 P92 0.9132
571 XQG 0.9131
572 MQN 0.9131
573 OXQ 0.9130
574 MAK 0.9130
575 BHO 0.9128
576 FQI 0.9128
577 GBD 0.9128
578 HQT 0.9128
579 RM1 0.9127
580 7WV 0.9124
581 2HQ 0.9123
582 LGC 0.9122
583 GAG 0.9121
584 RSF 0.9119
585 14J 0.9116
586 ANN 0.9115
587 ABI 0.9114
588 4WL 0.9113
589 LT2 0.9111
590 FBM 0.9111
591 3MC 0.9111
592 60P 0.9111
593 2EC 0.9111
594 6NT 0.9110
595 3NY 0.9109
596 ADA 0.9108
597 UY7 0.9108
598 DX4 0.9107
599 GLL 0.9107
600 5AC 0.9106
601 6MH 0.9106
602 HH5 0.9103
603 PNZ 0.9102
604 1LN 0.9102
605 69O 0.9101
606 141 0.9099
607 4JQ 0.9099
608 FOT 0.9099
609 51R 0.9098
610 MAE 0.9098
611 7N0 0.9097
612 7CZ 0.9097
613 2HU 0.9097
614 CFP 0.9094
615 2C9 0.9094
616 7WG 0.9094
617 98J 0.9094
618 42C 0.9093
619 RBL 0.9093
620 UGC 0.9091
621 TLA 0.9091
622 2ZX 0.9090
623 DUB 0.9089
624 IMR 0.9089
625 ZWZ 0.9089
626 3CE 0.9088
627 5QY 0.9088
628 6HQ 0.9088
629 BOA 0.9086
630 GJZ 0.9086
631 173 0.9085
632 SWD 0.9083
633 34D 0.9082
634 4YO 0.9081
635 SYV 0.9081
636 YIO 0.9080
637 SS2 0.9080
638 RUU 0.9080
639 MET 0.9080
640 EOL 0.9079
641 2MY 0.9078
642 HSE 0.9078
643 UNC 0.9077
644 KT7 0.9075
645 3FA 0.9073
646 KBG 0.9073
647 Q6T 0.9072
648 GIV 0.9072
649 JND 0.9071
650 23W 0.9071
651 URQ 0.9071
652 EA1 0.9070
653 6CS 0.9070
654 ARB 0.9070
655 284 0.9070
656 OXC 0.9068
657 ICC 0.9066
658 2DR 0.9066
659 92K 0.9065
660 AZ9 0.9064
661 DOR 0.9064
662 GTR 0.9064
663 2FY 0.9063
664 QIC 0.9062
665 DUC 0.9062
666 PE0 0.9061
667 SN4 0.9061
668 8IG 0.9061
669 7D2 0.9061
670 M2H 0.9060
671 1XX 0.9060
672 5FX 0.9060
673 OK7 0.9060
674 ASC 0.9059
675 258 0.9059
676 ECE 0.9058
677 2CM 0.9058
678 1XN 0.9058
679 HIO 0.9057
680 7MU 0.9057
681 TSU 0.9057
682 FCR 0.9057
683 HDH 0.9055
684 0W8 0.9054
685 IP0 0.9053
686 948 0.9053
687 JZ1 0.9053
688 6M4 0.9053
689 13X 0.9052
690 IJZ 0.9051
691 0TU 0.9051
692 285 0.9051
693 DE5 0.9050
694 TZE 0.9050
695 FBW 0.9049
696 SWA 0.9049
697 TMZ 0.9048
698 FFP 0.9048
699 SRT 0.9048
700 ICF 0.9047
701 7NI 0.9047
702 6NI 0.9047
703 MRZ 0.9046
704 268 0.9046
705 51F 0.9046
706 271 0.9045
707 CIZ 0.9044
708 4JT 0.9043
709 BEA 0.9042
710 6F0 0.9041
711 CEE 0.9041
712 TFU 0.9041
713 H3M 0.9040
714 AZ8 0.9040
715 HQD 0.9040
716 2TQ 0.9039
717 3MB 0.9039
718 3V4 0.9039
719 CAQ 0.9037
720 DYA 0.9037
721 BCU 0.9037
722 Q24 0.9036
723 JAW 0.9036
724 NVA 0.9036
725 E5X 0.9036
726 3IT 0.9035
727 SJ5 0.9035
728 N8Y 0.9034
729 GXE 0.9034
730 TMT 0.9033
731 OVM 0.9033
732 COI 0.9033
733 AX2 0.9032
734 ODO 0.9031
735 PAF 0.9030
736 FUF 0.9030
737 DMV 0.9030
738 GMN 0.9030
739 DIE 0.9029
740 069 0.9029
741 WDL 0.9028
742 SVD 0.9028
743 HHA 0.9028
744 BCP 0.9026
745 TAR 0.9025
746 QY9 0.9025
747 3SL 0.9023
748 J9W 0.9023
749 JZ5 0.9023
750 XLS 0.9022
751 G3F 0.9022
752 DZX 0.9022
753 GZL 0.9022
754 BZ2 0.9021
755 4XX 0.9020
756 SAN 0.9020
757 GZ3 0.9019
758 ROR 0.9019
759 M6N 0.9019
760 G6D 0.9019
761 AQO 0.9017
762 ARW 0.9017
763 EV0 0.9015
764 DTL 0.9015
765 AW5 0.9014
766 M5K 0.9014
767 DEE 0.9013
768 AH8 0.9013
769 2CH 0.9012
770 GXY 0.9012
771 MEW 0.9008
772 3MH 0.9008
773 AS3 0.9008
774 DAB 0.9006
775 FLM 0.9006
776 RB5 0.9005
777 XYL 0.9005
778 RB0 0.9005
779 HCS 0.9004
780 G5V 0.9003
781 9MG 0.9002
782 BEW 0.9001
783 9YL 0.9000
784 R8V 0.9000
785 FBV 0.8999
786 93Q 0.8999
787 8CL 0.8999
788 15L 0.8998
789 4NM 0.8998
790 AKH 0.8998
791 2PC 0.8997
792 1DU 0.8994
793 RHU 0.8991
794 C2U 0.8991
795 URP 0.8991
796 FUB 0.8990
797 PKU 0.8990
798 94B 0.8989
799 94N 0.8989
800 MUC 0.8987
801 SHG 0.8987
802 8EZ 0.8986
803 THE 0.8986
804 LER 0.8986
805 AMH 0.8986
806 SIN 0.8985
807 GRE 0.8985
808 5ZE 0.8985
809 MWP 0.8985
810 AZF 0.8985
811 HSM 0.8984
812 7VS 0.8983
813 ILE 0.8981
814 PXL 0.8981
815 92Z 0.8981
816 YHO 0.8981
817 F9P 0.8980
818 YTB 0.8980
819 GCU 0.8980
820 XXR 0.8980
821 5DI 0.8978
822 ISD 0.8978
823 AMG 0.8978
824 NDH 0.8977
825 1AN 0.8976
826 LYL 0.8976
827 6M1 0.8975
828 CRN 0.8974
829 JFJ 0.8974
830 4P0 0.8974
831 265 0.8973
832 MBN 0.8973
833 OTR 0.8973
834 BR8 0.8971
835 8LG 0.8971
836 94W 0.8970
837 449 0.8970
838 SKA 0.8969
839 L89 0.8969
840 39A 0.8968
841 FA3 0.8968
842 FBS 0.8967
843 OXE 0.8967
844 L3Q 0.8967
845 SF9 0.8966
846 CTL 0.8966
847 BDR 0.8965
848 TTO 0.8965
849 HTS 0.8963
850 QBK 0.8962
851 IOM 0.8961
852 2AF 0.8961
853 TEP 0.8960
854 UFV 0.8960
855 4HC 0.8959
856 3Z8 0.8959
857 MO8 0.8958
858 CWJ 0.8958
859 JZ0 0.8958
860 40E 0.8958
861 5AN 0.8957
862 TIU 0.8957
863 GOO 0.8957
864 2PG 0.8956
865 IT2 0.8955
866 K5W 0.8955
867 2ZV 0.8953
868 FRU 0.8952
869 JB8 0.8952
870 3AY 0.8952
871 HZP 0.8951
872 N8P 0.8951
873 UEG 0.8950
874 IPH 0.8950
875 0N7 0.8950
876 4J8 0.8950
877 BPN 0.8949
878 PEP 0.8949
879 AEH 0.8948
880 G3P 0.8948
881 VXX 0.8947
882 JDN 0.8946
883 DNF 0.8945
884 HYP 0.8945
885 2KT 0.8944
886 76X 0.8944
887 3PY 0.8943
888 7WR 0.8942
889 URS 0.8942
890 FEH 0.8941
891 F5B 0.8940
892 XX3 0.8939
893 OW4 0.8939
894 PRO 0.8939
895 2AS 0.8939
896 4RW 0.8938
897 RAM 0.8938
898 WOT 0.8937
899 DQA 0.8937
900 FP2 0.8936
901 MRY 0.8936
902 BNF 0.8936
903 OVP 0.8935
904 KJU 0.8934
905 AJ2 0.8933
906 ESP 0.8933
907 HHN 0.8931
908 ERH 0.8931
909 PAC 0.8928
910 TP5 0.8928
911 KIV 0.8928
912 ARA 0.8927
913 DTU 0.8927
914 ICB 0.8926
915 RAT 0.8925
916 PRY 0.8925
917 JBN 0.8925
918 H7Y 0.8924
919 APZ 0.8924
920 O7U 0.8924
921 DAS 0.8923
922 CGB 0.8923
923 7VJ 0.8922
924 TZC 0.8922
925 PMB 0.8922
926 NVI 0.8922
927 MLE 0.8921
928 TYL 0.8921
929 TEO 0.8919
930 6FZ 0.8919
931 938 0.8917
932 TWO 0.8917
933 NEQ 0.8917
934 TTL 0.8917
935 DIU 0.8916
936 KMT 0.8916
937 VAH 0.8916
938 MXN 0.8916
939 6X8 0.8915
940 3R6 0.8914
941 3AP 0.8913
942 4AP 0.8913
943 M1E 0.8913
944 MFB 0.8913
945 IHG 0.8913
946 E60 0.8912
947 MSN 0.8912
948 GLT 0.8911
949 DBX 0.8910
950 FX1 0.8910
951 3RK 0.8909
952 2GS 0.8909
953 HIS 0.8907
954 ALO 0.8906
955 LEU 0.8905
956 M1H 0.8905
957 1DJ 0.8905
958 PBE 0.8904
959 KYD 0.8903
960 2AP 0.8902
961 HVK 0.8902
962 259 0.8902
963 GUA 0.8902
964 25W 0.8901
965 R9S 0.8901
966 TMH 0.8899
967 TCZ 0.8897
968 SMV 0.8896
969 3MA 0.8895
970 PPR 0.8894
971 HLZ 0.8894
972 TTY 0.8892
973 ONL 0.8892
974 FOA 0.8891
975 CYH 0.8891
976 A65 0.8890
977 1DV 0.8889
978 XHP 0.8889
979 PYC 0.8889
980 GYP 0.8888
981 0JD 0.8887
982 12M 0.8887
983 2IM 0.8886
984 TM4 0.8885
985 AL0 0.8885
986 A13 0.8885
987 YAN 0.8883
988 MNN 0.8883
989 3ZQ 0.8883
990 3FH 0.8882
991 XXG 0.8881
992 LFR 0.8881
993 GCB 0.8880
994 KBB 0.8880
995 AKG 0.8880
996 92P 0.8879
997 J6W 0.8879
998 9FL 0.8879
999 LKA 0.8879
1000 KG7 0.8879
1001 C21 0.8878
1002 97T 0.8876
1003 329 0.8876
1004 PQ0 0.8875
1005 MFU 0.8875
1006 9PO 0.8874
1007 HY3 0.8874
1008 PIH 0.8873
1009 GLY PRO 0.8873
1010 495 0.8873
1011 M6W 0.8872
1012 EYK 0.8872
1013 HRZ 0.8871
1014 9ZE 0.8870
1015 34V 0.8870
1016 5CL 0.8870
1017 2RH 0.8869
1018 ITN 0.8869
1019 DIG 0.8869
1020 PXM 0.8868
1021 44W 0.8868
1022 HZQ 0.8868
1023 MT0 0.8867
1024 CXL 0.8867
1025 IPZ 0.8866
1026 24T 0.8865
1027 THR 0.8865
1028 12T 0.8864
1029 15N 0.8864
1030 1DH 0.8863
1031 B62 0.8861
1032 N7P 0.8861
1033 DBJ 0.8861
1034 TPA 0.8861
1035 PYQ 0.8860
1036 HJP 0.8860
1037 GLN 0.8860
1038 BAE 0.8860
1039 FPK 0.8859
1040 FBJ 0.8858
1041 UAN 0.8857
1042 93B 0.8857
1043 AEG 0.8857
1044 HXX 0.8856
1045 OMD 0.8854
1046 OTW 0.8853
1047 PFB 0.8853
1048 FB1 0.8852
1049 280 0.8851
1050 2CO 0.8851
1051 2MN 0.8850
1052 LGA 0.8850
1053 44V 0.8849
1054 25T 0.8849
1055 GIO 0.8849
1056 AAS 0.8849
1057 FB2 0.8848
1058 TGX 0.8848
1059 AUD 0.8848
1060 HAI 0.8847
1061 40O 0.8847
1062 HC4 0.8845
1063 DQU 0.8844
1064 EMZ 0.8844
1065 2FT 0.8841
1066 HGW 0.8840
1067 XBT 0.8839
1068 SNE 0.8838
1069 NLE 0.8836
1070 M1Q 0.8836
1071 R9Y 0.8836
1072 VAL 0.8836
1073 9CA 0.8835
1074 RNT 0.8835
1075 AMS 0.8835
1076 4MU 0.8835
1077 HQJ 0.8835
1078 GLY ALA 0.8834
1079 KPL 0.8832
1080 J9Q 0.8832
1081 3MG 0.8832
1082 EVA 0.8829
1083 MUA 0.8829
1084 5LA 0.8827
1085 SKG 0.8826
1086 9FE 0.8825
1087 3WA 0.8825
1088 LNO 0.8822
1089 NDM 0.8821
1090 NXA 0.8821
1091 EXO 0.8820
1092 CMS 0.8820
1093 TFB 0.8820
1094 K34 0.8819
1095 ESI 0.8818
1096 II6 0.8818
1097 SF6 0.8818
1098 SOR 0.8817
1099 B2J 0.8816
1100 7ME 0.8814
1101 ZBT 0.8813
1102 INS 0.8812
1103 PRZ 0.8811
1104 HDA 0.8811
1105 4NG 0.8808
1106 PRF 0.8807
1107 DRL 0.8807
1108 L5V 0.8807
1109 4BZ 0.8807
1110 GTL 0.8803
1111 T2C 0.8803
1112 428 0.8802
1113 9ON 0.8802
1114 ESX 0.8802
1115 JTH 0.8801
1116 SEP 0.8801
1117 A2Q 0.8799
1118 278 0.8797
1119 HX2 0.8796
1120 QX4 0.8796
1121 9TY 0.8794
1122 MSE 0.8794
1123 GOJ 0.8792
1124 CTS 0.8792
1125 BVG 0.8792
1126 HA5 0.8791
1127 PBA 0.8789
1128 1IT 0.8788
1129 52C 0.8788
1130 PRS 0.8785
1131 4PW 0.8785
1132 0FO 0.8784
1133 1DQ 0.8783
1134 TSS 0.8782
1135 4ME 0.8781
1136 32X 0.8781
1137 RMN 0.8781
1138 L60 0.8780
1139 NQ 0.8780
1140 5GU 0.8779
1141 PDC 0.8778
1142 M0Q 0.8777
1143 MD0 0.8777
1144 VK3 0.8776
1145 K6H 0.8776
1146 BVC 0.8774
1147 E7S 0.8773
1148 KTW 0.8773
1149 0FN 0.8770
1150 6ME 0.8765
1151 9RW 0.8765
1152 AHB 0.8764
1153 9R5 0.8763
1154 KTA 0.8759
1155 5WX 0.8758
1156 QPR 0.8757
1157 HIU 0.8757
1158 OHP 0.8756
1159 V1L 0.8756
1160 MLI 0.8756
1161 ABA 0.8755
1162 MED 0.8753
1163 FSG 0.8752
1164 FLA 0.8752
1165 CYS 0.8752
1166 XSP 0.8751
1167 4VY 0.8749
1168 9PY 0.8748
1169 MLA 0.8743
1170 KP6 0.8743
1171 INE 0.8742
1172 CEJ 0.8742
1173 SC2 0.8740
1174 SER 0.8740
1175 CSS 0.8740
1176 3AL 0.8740
1177 NYL 0.8738
1178 1SA 0.8735
1179 X09 0.8735
1180 03W 0.8733
1181 DGY 0.8733
1182 PRI 0.8732
1183 13P 0.8732
1184 8OZ 0.8731
1185 MA3 0.8731
1186 C2N 0.8729
1187 KIB 0.8729
1188 260 0.8729
1189 MVN 0.8724
1190 I4B 0.8723
1191 23J 0.8722
1192 PIM 0.8720
1193 DCY 0.8718
1194 DS0 0.8718
1195 AX3 0.8717
1196 PGA 0.8717
1197 TZL 0.8713
1198 PD2 0.8709
1199 6JN 0.8709
1200 0W1 0.8708
1201 DHY 0.8708
1202 SPV 0.8707
1203 C5J 0.8706
1204 J9N 0.8703
1205 NK2 0.8699
1206 0F9 0.8698
1207 36E 0.8694
1208 6VD 0.8693
1209 UNJ 0.8693
1210 HVQ 0.8691
1211 DPR 0.8690
1212 15E 0.8690
1213 273 0.8689
1214 P2D 0.8688
1215 PRA 0.8687
1216 FHN 0.8686
1217 3C4 0.8686
1218 G3H 0.8685
1219 S2G 0.8684
1220 DQN 0.8683
1221 SKJ 0.8683
1222 264 0.8682
1223 O2A 0.8681
1224 OGA 0.8678
1225 SYA 0.8676
1226 LSA 0.8676
1227 3HP 0.8676
1228 7ZE 0.8674
1229 DSN 0.8674
1230 H62 0.8673
1231 PAH 0.8671
1232 DMG 0.8668
1233 293 0.8667
1234 F4E 0.8662
1235 QMP 0.8661
1236 DLY 0.8658
1237 YPN 0.8657
1238 M4S 0.8655
1239 S24 0.8653
1240 F12 0.8649
1241 4BY 0.8647
1242 HQ9 0.8647
1243 DXX 0.8646
1244 SMN 0.8645
1245 SNO 0.8640
1246 SFU 0.8638
1247 NF3 0.8633
1248 X05 0.8631
1249 IAC 0.8631
1250 1U6 0.8630
1251 MJ2 0.8629
1252 0LH 0.8624
1253 BNT 0.8624
1254 K32 0.8623
1255 SXS 0.8623
1256 M0W 0.8622
1257 MSR 0.8620
1258 RNO 0.8620
1259 GCO 0.8619
1260 2IT 0.8618
1261 2EH 0.8616
1262 0V5 0.8614
1263 FBU 0.8605
1264 MZB 0.8605
1265 8NB 0.8604
1266 YSO 0.8600
1267 3ZB 0.8597
1268 JYD 0.8595
1269 4NB 0.8594
1270 4SD 0.8591
1271 GRO 0.8589
1272 ONR 0.8587
1273 EXD 0.8585
1274 L14 0.8583
1275 N2Z 0.8579
1276 192 0.8579
1277 AC5 0.8577
1278 6KT 0.8575
1279 LQ2 0.8568
1280 I3E 0.8566
1281 GV9 0.8565
1282 DNC 0.8562
1283 GF4 0.8562
1284 ZB1 0.8561
1285 I2M 0.8552
1286 DTT 0.8549
1287 GG6 0.8549
1288 IPM 0.8546
1289 SRO 0.8538
1290 QAS 0.8537
1291 8EW 0.8526
1292 HHH 0.8524
1293 VPR 0.8515
Ligand no: 2; Ligand: SIS; Similar ligands found: 4
No: Ligand Similarity coefficient
1 KAN 0.8958
2 KNC 0.8828
3 9CS 0.8825
4 CK0 0.8806
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 5C4L; Ligand: SIS; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 5c4l.bio2) has 32 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 5C4L; Ligand: 4XR; Similar sites found with APoc: 1
This union binding pocket(no: 2) in the query (biounit: 5c4l.bio1) has 31 residues
No: Leader PDB Ligand Sequence Similarity
1 6CGD GNP 49.1803
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