Receptor
PDB id Resolution Class Description Source Keywords
5CU2 1.71 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CK2ALPHA WITH 2-HYDROXY-5-METHYLBENZOIC (METHYL 4-((3-(3-CHLORO-4-(PHENYL)BENZYLAMINO)PROPYL)AMINO)O XOBUTANOAT BOUND HOMO SAPIENS CK2ALPHA CK2A FRAGMENT BASED DRUG DISCOVERY HIGH CONCENTRSCREENING SELECTIVE ATP COMPETITIVE INHIBITORS SURFACE ENREDUCTION TRANSFERASE
Ref.: A FRAGMENT-BASED APPROACH LEADING TO THE DISCOVERY NOVEL BINDING SITE AND THE SELECTIVE CK2 INHIBITOR BIOORG. MED. CHEM. V. 25 3471 2017
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACT B:405;
A:407;
A:406;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
59.044 C2 H3 O2 CC(=O...
54G B:403;
A:404;
Valid;
Valid;
none;
none;
submit data
152.147 C8 H8 O3 Cc1cc...
PO4 B:404;
A:405;
Invalid;
Invalid;
none;
none;
submit data
94.971 O4 P [O-]P...
551 A:403;
B:401;
B:402;
A:401;
A:402;
Valid;
Valid;
Valid;
Valid;
Valid;
Atoms found LESS than expected: % Diff = 0.423;
none;
Atoms found LESS than expected: % Diff = 0.423;
none;
Atoms found LESS than expected: % Diff = 0.308;
submit data
374.861 C20 H23 Cl N2 O3 COC(=...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5H8E 2.15 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF CK2 WITH COMPOUND 7H HOMO SAPIENS KINASE INHIBITOR CK2 TRANSFERASE-TRANSFERASE INHIBITOR CO
Ref.: POTENT AND SELECTIVE CK2 KINASE INHIBITORS WITH EFF WNT PATHWAY SIGNALING IN VIVO. ACS MED.CHEM.LETT. V. 7 300 2016
Members (123)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 133 families.
1 4FBX - 0TJ GLY ASP ASP ASP ASP ASP n/a n/a
2 6L21 - E3U C16 H12 O6 c1cc(c(c2c....
3 5OUU - AWN C22 H20 Cl N3 c1ccc(cc1)....
4 4RLL - E91 C21 H14 N2 O2 c1ccc2c(c1....
5 5CU4 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
6 6HOT - CIY C10 H10 O3 COc1cc(ccc....
7 5ORJ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
8 3MB6 ic50 = 100 nM 01I C16 H8 O6 c1cc2c(cc(....
9 5M4F - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
10 6A1C - 9NX C17 H15 Br N4 O2 S COc1cc(c(c....
11 6EHU - B5E C25 H24 F3 N3 CCc1ccccc1....
12 5CVH - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
13 3BQC ic50 ~ 2 uM EMO C15 H10 O5 Cc1cc2c(c(....
14 6L22 - E3U C16 H12 O6 c1cc(c(c2c....
15 5N9K Ki = 0.46 nM 8QK C20 H13 Cl2 N O4 COc1ccc(cc....
16 5OTQ - AUH C25 H27 N3 O CCc1ccccc1....
17 5CU2 - 54G C8 H8 O3 Cc1ccc(c(c....
18 5MO5 - 4IH C17 H21 Cl N2 O2 S CS(=O)(=O)....
19 5M4I - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
20 5MP8 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
21 6HOR - GJK C11 H12 O3 CC(=O)/C=C....
22 5MOV - HC4 C9 H8 O3 c1cc(ccc1C....
23 5MOH - YTX C9 H10 O4 COc1cc(ccc....
24 6JWA ic50 = 10.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
25 6HNW ic50 = 200 nM CUE C15 H8 O5 c1cc2c(cc1....
26 5CSH Kd = 270 uM 54E C13 H12 Cl N c1ccc(cc1)....
27 7A49 ic50 = 3.26 uM QWN C5 H2 Br Cl N4 c1c2c(nc(c....
28 5OTL - AQT C25 H26 Cl N3 O CCc1ccccc1....
29 5ORK Kd = 234 uM A4T C13 H11 Cl F N c1ccc(c(c1....
30 7A4B ic50 = 2.56 uM QXW C5 H2 Br2 N4 c1c2c(nc(c....
31 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
32 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
33 5H8G Kd = 48.2 pM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
34 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
35 6YPJ - P5W C16 H12 N2 O2 S c1ccc(cc1)....
36 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
37 6HOQ - FER C10 H10 O4 COc1cc(ccc....
38 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
39 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
40 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
41 6RCB ic50 = 0.33 uM JYZ C17 H14 N2 O4 COc1cc(ccc....
42 6HME - FXB C21 H21 N O3 CC(C)n1c2c....
43 6HOP - FER C10 H10 O4 COc1cc(ccc....
44 5OTO - AQW C24 H23 Cl2 N3 CCc1ccccc1....
45 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
46 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
47 6RFF ic50 = 0.37 uM K1B C12 H6 Br N5 O4 S c1cc(c(cc1....
48 6EII - B5W C22 H23 Cl N c1ccc(cc1)....
49 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
50 5H8E Kd = 6.33 pM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
51 5OWH - B0K C10 H9 Br4 N3 c1nc2c(n1C....
52 6L1Z - E3U C16 H12 O6 c1cc(c(c2c....
53 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
54 5MOE Kd = 520 uM OQC C11 H10 Cl N O c1cc(c(cc1....
55 5OUE - AVZ C18 H19 Cl N3 c1ccc(cc1)....
56 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
57 6RB1 ic50 = 1.37 uM JWQ C14 H9 F3 N4 O3 S COc1cc(ccc....
58 6TEI - N4N C15 H11 N3 O2 S c1ccnc(c1)....
59 5OWL - B0K C10 H9 Br4 N3 c1nc2c(n1C....
60 6HBN - FXB C21 H21 N O3 CC(C)n1c2c....
61 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
62 5OTR - AU8 C13 H12 Cl2 N c1ccc(cc1)....
63 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
64 5OSL - A9K C13 H12 Cl N O c1ccc(c(c1....
65 5N9N Ki = 0.41 nM KC5 C20 H15 Cl2 N O4 COc1ccc(cc....
66 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
67 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
68 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
69 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
70 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
71 5OTH - AQ8 C25 H26 Cl N3 O CCc1ccccc1....
72 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
73 6YPK - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
74 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
75 5OTI - AOK C25 H26 Cl N3 CCc1ccccc1....
76 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
77 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
78 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
79 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
80 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
81 6YPH - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
82 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
83 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
84 6RCM ic50 = 0.36 uM K0N C17 H18 N4 O3 S CC(C)(C)c1....
85 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
86 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
87 6SPX ic50 = 44 uM DAS ASP ASP ASP ASP ASP LYS 9AB n/a n/a
88 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
89 5N9L Ki = 15 nM 8QH C20 H15 Cl2 N O3 Cc1ccc(cc1....
90 5OT5 - AWK C25 H26 Cl N3 CCc1ccccc1....
91 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
92 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
93 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
94 5OQU - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
95 6GIH - EZN C15 H13 Cl N2 c1cc(c2cc[....
96 6RFE ic50 = 0.28 uM K0Z C13 H9 Br N4 O3 S COc1cc(ccc....
97 6YPG - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
98 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
99 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
100 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
101 3PE1 Ki = 0.223 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
102 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
103 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
104 5ORH Kd = 41 uM A4N C14 H14 Cl N Cc1ccccc1c....
105 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
106 2ZJW Ki = 0.02 uM REF C14 H6 O8 c1c2c-3c(c....
107 6HOU - V55 C8 H8 O3 COc1cc(ccc....
108 7A4C ic50 = 3.82 uM QWW C5 H Br3 N4 c12c(c(c(n....
109 6YPN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
110 5OSZ - AHK C24 H25 Cl N3 CCc1ccccc1....
111 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
112 5OT6 - AJK C19 H20 Cl N2 c1ccc(cc1)....
113 6EHK - AUW C24 H23 Cl2 N3 CCc1ccccc1....
114 6L24 - E3U C16 H12 O6 c1cc(c(c2c....
115 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
116 5OS8 - J27 C14 H14 Cl F N Cc1cc(ccc1....
117 5OTY - AUW C24 H23 Cl2 N3 CCc1ccccc1....
118 5OTD - AOW C24 H24 Cl N4 O2 CCc1ccccc1....
119 6GMD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
120 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
121 6HNY - GHT C19 H19 N O4 CN1CCc2cc(....
122 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
123 5OUL - AWE C13 H11 Cl F N c1cc(cc(c1....
70% Homology Family (183)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 101 families.
1 4FBX - 0TJ GLY ASP ASP ASP ASP ASP n/a n/a
2 6L21 - E3U C16 H12 O6 c1cc(c(c2c....
3 5OUU - AWN C22 H20 Cl N3 c1ccc(cc1)....
4 4RLL - E91 C21 H14 N2 O2 c1ccc2c(c1....
5 5CU4 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
6 6HOT - CIY C10 H10 O3 COc1cc(ccc....
7 5ORJ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
8 3MB6 ic50 = 100 nM 01I C16 H8 O6 c1cc2c(cc(....
9 5M4F - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
10 6A1C - 9NX C17 H15 Br N4 O2 S COc1cc(c(c....
11 6EHU - B5E C25 H24 F3 N3 CCc1ccccc1....
12 5CVH - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
13 3BQC ic50 ~ 2 uM EMO C15 H10 O5 Cc1cc2c(c(....
14 6L22 - E3U C16 H12 O6 c1cc(c(c2c....
15 5N9K Ki = 0.46 nM 8QK C20 H13 Cl2 N O4 COc1ccc(cc....
16 5OTQ - AUH C25 H27 N3 O CCc1ccccc1....
17 5CU2 - 54G C8 H8 O3 Cc1ccc(c(c....
18 5MO5 - 4IH C17 H21 Cl N2 O2 S CS(=O)(=O)....
19 5M4I - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
20 5MP8 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
21 6HOR - GJK C11 H12 O3 CC(=O)/C=C....
22 5MOV - HC4 C9 H8 O3 c1cc(ccc1C....
23 5MOH - YTX C9 H10 O4 COc1cc(ccc....
24 6JWA ic50 = 10.9 uM 5ID C11 H13 I N4 O4 c1c(c2c(nc....
25 6HNW ic50 = 200 nM CUE C15 H8 O5 c1cc2c(cc1....
26 5CSH Kd = 270 uM 54E C13 H12 Cl N c1ccc(cc1)....
27 7A49 ic50 = 3.26 uM QWN C5 H2 Br Cl N4 c1c2c(nc(c....
28 5OTL - AQT C25 H26 Cl N3 O CCc1ccccc1....
29 5ORK Kd = 234 uM A4T C13 H11 Cl F N c1ccc(c(c1....
30 7A4B ic50 = 2.56 uM QXW C5 H2 Br2 N4 c1c2c(nc(c....
31 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
32 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
33 5H8G Kd = 48.2 pM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
34 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
35 6YPJ - P5W C16 H12 N2 O2 S c1ccc(cc1)....
36 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
37 6HOQ - FER C10 H10 O4 COc1cc(ccc....
38 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
39 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
40 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
41 6RCB ic50 = 0.33 uM JYZ C17 H14 N2 O4 COc1cc(ccc....
42 6HME - FXB C21 H21 N O3 CC(C)n1c2c....
43 6HOP - FER C10 H10 O4 COc1cc(ccc....
44 5OTO - AQW C24 H23 Cl2 N3 CCc1ccccc1....
45 3AT4 Kd = 2.26 nM CCK C20 H20 N6 O2 CC(C)Nc1cc....
46 3OWJ Ki = 0.86 uM 1EL C17 H14 N2 O2 Cc1c2c(c(c....
47 6RFF ic50 = 0.37 uM K1B C12 H6 Br N5 O4 S c1cc(c(cc1....
48 6EII - B5W C22 H23 Cl N c1ccc(cc1)....
49 5CU0 - 54R C18 H21 Cl N2 O CC(=O)NCCC....
50 5H8E Kd = 6.33 pM 5Y3 C21 H25 N9 O CC(=O)Nc1c....
51 5OWH - B0K C10 H9 Br4 N3 c1nc2c(n1C....
52 6L1Z - E3U C16 H12 O6 c1cc(c(c2c....
53 3WAR - NIO C6 H5 N O2 c1cc(cnc1)....
54 5MOE Kd = 520 uM OQC C11 H10 Cl N O c1cc(c(cc1....
55 5OUE - AVZ C18 H19 Cl N3 c1ccc(cc1)....
56 5MOD Kd = 300 uM 86L C10 H14 Cl N O CC(C)Oc1cc....
57 6RB1 ic50 = 1.37 uM JWQ C14 H9 F3 N4 O3 S COc1cc(ccc....
58 6TEI - N4N C15 H11 N3 O2 S c1ccnc(c1)....
59 5OWL - B0K C10 H9 Br4 N3 c1nc2c(n1C....
60 6HBN - FXB C21 H21 N O3 CC(C)n1c2c....
61 5CU3 Kd = 0.32 uM 54S C26 H26 Cl N3 O4 c1ccc(cc1)....
62 5OTR - AU8 C13 H12 Cl2 N c1ccc(cc1)....
63 4KWP Ki = 0.04 uM EXX C12 H10 Br4 N2 O3 c1nc2c(n1[....
64 5OSL - A9K C13 H12 Cl N O c1ccc(c(c1....
65 5N9N Ki = 0.41 nM KC5 C20 H15 Cl2 N O4 COc1ccc(cc....
66 5CSP Kd = 58 uM 54G C8 H8 O3 Cc1ccc(c(c....
67 5CTP - 54R C18 H21 Cl N2 O CC(=O)NCCC....
68 5MOW - BR9 C5 H6 Br N3 c1c(cnc(c1....
69 4UB7 Ki = 2.5 nM 3G5 C16 H8 Br2 O5 c1cc(ccc1C....
70 5MMF - JMB C16 H19 Cl N CCC[NH2+]C....
71 5OTH - AQ8 C25 H26 Cl N3 O CCc1ccccc1....
72 1PJK - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
73 6YPK - GDP C10 H15 N5 O11 P2 c1nc2c(n1[....
74 3NSZ - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
75 5OTI - AOK C25 H26 Cl N3 CCc1ccccc1....
76 3AXW - TID C9 H7 N3 O2 S c1cc(ccc1c....
77 5MO6 - KXZ C19 H21 Cl N2 O3 c1ccc(cc1)....
78 2PVR - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
79 3C13 - EMO C15 H10 O5 Cc1cc2c(c(....
80 5CS6 Kd = 630 uM K82 C10 H14 Cl N O CCCOc1ccc(....
81 6YPH - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
82 3PE2 Ki = 0.175 nM E1B C20 H12 N4 O2 C#Cc1cccc(....
83 5CT0 - 54P C16 H18 Cl N O c1ccc(cc1)....
84 6RCM ic50 = 0.36 uM K0N C17 H18 N4 O3 S CC(C)(C)c1....
85 5CU6 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
86 5M4C - 7EY C16 H14 N2 O2 S2 Cc1ccc(cc1....
87 6SPX ic50 = 44 uM DAS ASP ASP ASP ASP ASP LYS 9AB n/a n/a
88 5MO7 - YRA C16 H17 Cl N2 O c1ccc(cc1)....
89 5N9L Ki = 15 nM 8QH C20 H15 Cl2 N O3 Cc1ccc(cc1....
90 5OT5 - AWK C25 H26 Cl N3 CCc1ccccc1....
91 3OWK ic50 = 1.5 uM 18E C16 H11 Cl N2 O Cc1cnc(c2c....
92 5MMR - H83 C17 H21 Cl N2 c1ccc(cc1)....
93 5MPJ - J2P C15 H17 Cl N CC[NH2+]Cc....
94 5OQU - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
95 6GIH - EZN C15 H13 Cl N2 c1cc(c2cc[....
96 6RFE ic50 = 0.28 uM K0Z C13 H9 Br N4 O3 S COc1cc(ccc....
97 6YPG - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
98 5CSV - GAB C7 H7 N O2 c1cc(cc(c1....
99 5MOT - HBD C7 H7 N O2 c1cc(ccc1C....
100 3R0T ic50 = 0.91 nM FU9 C22 H16 F3 N5 O2 c1cc(cc(c1....
101 3PE1 Ki = 0.223 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
102 3JUH - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
103 5CLP - 42J C8 H9 Cl2 N c1cc(c(cc1....
104 5ORH Kd = 41 uM A4N C14 H14 Cl N Cc1ccccc1c....
105 3H30 Ki = 29.2 uM RFZ C12 H12 Cl2 N2 O4 c1c2c(cc(c....
106 2ZJW Ki = 0.02 uM REF C14 H6 O8 c1c2c-3c(c....
107 6HOU - V55 C8 H8 O3 COc1cc(ccc....
108 7A4C ic50 = 3.82 uM QWW C5 H Br3 N4 c12c(c(c(n....
109 6YPN - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
110 5OSZ - AHK C24 H25 Cl N3 CCc1ccccc1....
111 4GRB ic50 = 17 nM 0XG C19 H18 N4 O4 S CN(C)C(=O)....
112 5OT6 - AJK C19 H20 Cl N2 c1ccc(cc1)....
113 6EHK - AUW C24 H23 Cl2 N3 CCc1ccccc1....
114 6L24 - E3U C16 H12 O6 c1cc(c(c2c....
115 3MB7 ic50 = 200 nM 14I C16 H8 O6 c1cc2c(cc(....
116 5OS8 - J27 C14 H14 Cl F N Cc1cc(ccc1....
117 5OTY - AUW C24 H23 Cl2 N3 CCc1ccccc1....
118 5OTD - AOW C24 H24 Cl N4 O2 CCc1ccccc1....
119 6GMD - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
120 5CVF - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
121 6HNY - GHT C19 H19 N O4 CN1CCc2cc(....
122 5CX9 - 551 C20 H23 Cl N2 O3 COC(=O)CC(....
123 5OUL - AWE C13 H11 Cl F N c1cc(cc(c1....
124 6TEW - N5Q C20 H14 N2 O3 S c1ccc2cc(c....
125 5Y9M - NIO C6 H5 N O2 c1cc(cnc1)....
126 7A1B ic50 = 2.36 uM QXW C5 H2 Br2 N4 c1c2c(nc(c....
127 7A2H - QX2 C6 H2 Br3 N3 c1[nH]c2c(....
128 5M56 - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
129 5M4U - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
130 6HMD - GDW C21 H24 N2 O2 CCN(CC)CCn....
131 6HMQ - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
132 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
133 7A1Z ic50 = 3.38 uM QWN C5 H2 Br Cl N4 c1c2c(nc(c....
134 6TE2 - N4N C15 H11 N3 O2 S c1ccnc(c1)....
135 6HMB - 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
136 7A22 ic50 = 1.98 uM QWW C5 H Br3 N4 c12c(c(c(n....
137 3OFM - 4B0 C9 H7 Br4 N3 O C(Cn1c2c(c....
138 6HMC - FXB C21 H21 N O3 CC(C)n1c2c....
139 5YF9 - NIO C6 H5 N O2 c1cc(cnc1)....
140 6TGU - N92 C16 H11 Cl N2 O3 S c1cc(ccc1c....
141 2PVH Ki = 0.26 uM P19 C17 H14 N6 c1ccc(cc1)....
142 1M2P - HNA C14 H7 N O6 c1cc2c(c(c....
143 1LPU - BEN C7 H8 N2 [H]/N=C(c1....
144 2QC6 ic50 = 0.1 uM G12 C10 H6 Br2 O3 CC1=C(C(=O....
145 4ANM ic50 = 28 nM WUL C15 H14 Br N3 O3 c1cc2c(cc1....
146 1DAW - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
147 4RLK - E91 C21 H14 N2 O2 c1ccc2c(c1....
148 2OXD - K32 C7 H2 Br4 N2 O c12c(c(c(c....
149 2PVM Ki = 0.36 uM P29 C17 H15 N9 c1ccc(cc1)....
150 1J91 - TBS C6 H Br4 N3 c12c(c(c(c....
151 3FL5 - TXQ C14 H8 O6 c1cc(c(c2c....
152 3PWD Ki = 0.22 uM CZ0 C14 H9 N O5 CC1=CC(=O)....
153 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
154 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
155 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
156 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
157 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
158 4DGN ic50 = 0.35 uM LU2 C15 H10 O6 c1cc(c(cc1....
159 1M2Q - MNX C13 H7 N O6 c1cc(c2c(c....
160 2OXY - K17 C7 H2 Br4 N2 c1[nH]c2c(....
161 1M2R - MNY C14 H10 N2 O4 c1cc(c2c(c....
162 3KXN - K8X C7 H2 I4 N2 c1[nH]c2c(....
163 6QS5 ic50 = 0.57 uM JGB C10 H8 N2 O3 c1cc(c(cc1....
164 1ZOE Ki = 0.04 uM K25 C9 H7 Br4 N3 CN(C)c1[nH....
165 2PVL Ki = 0.024 uM P55 C18 H20 N8 CCN1CCN(CC....
166 1LP4 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
167 2PVN Ki = 0.00035 uM P63 C20 H16 N8 O CC(=O)Nc1c....
168 3KXG - K6X C7 H Br5 N2 c12c(c(c(c....
169 3BE9 Ki = 24 nM P04 C19 H21 N7 O c1cc2cc(c1....
170 2OXX - K22 C7 H2 Br4 N2 S c12c(c(c(c....
171 3KXM - K74 C11 H9 Br4 N3 O S CNC(=O)CSc....
172 1LR4 - BEN C7 H8 N2 [H]/N=C(c1....
173 1OM1 Ki = 0.17 uM IQA C17 H12 N2 O3 c1ccc2c(c1....
174 1ZOH Ki = 0.1 uM K44 C10 H7 Br4 N3 C[N@@]1CCn....
175 2PVK Ki = 0.008 uM P45 C19 H14 Cl N7 c1ccc(cc1)....
176 1DAY - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
177 6KO6 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
178 6K3L Kd = 60.1 nM 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
179 6ISJ - 3NG C19 H12 Cl N3 O2 c1cc(cc(c1....
180 5OMY - 9YE C23 H25 N O3 CC(C)n1c2c....
181 6SPW ic50 = 4.5 uM DAS ASP ASP ASP ASP ASP LYS A0Z n/a n/a
182 5ONI - 9YE C23 H25 N O3 CC(C)n1c2c....
183 6XX7 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
50% Homology Family (80)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 3PXQ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
2 2R3N ic50 = 70 nM SCZ C21 H19 N5 c1ccc(cc1)....
3 1H0V - UN4 C10 H12 N6 O2 c1[nH]c2c(....
4 4NJ3 Kd = 0.3 uM 2KD C27 H21 Cl N2 O6 COC(=O)[C@....
5 1JSV - U55 C10 H11 N5 O2 S c1cc(ccc1N....
6 1OIQ ic50 = 2.9 uM HDU C14 H13 N5 O Cc1c(n2ccc....
7 2W17 ic50 = 0.002 uM I19 C24 H30 F N7 O Cc1ncc(n1C....
8 2VTP ic50 = 0.003 uM LZ9 C17 H11 F3 N4 O2 c1cc(c(c(c....
9 1JVP ic50 = 1.6 uM LIG C15 H11 N3 c1ccc-2c(c....
10 1FVT - 106 C14 H11 Br N4 O3 S c1cc(ccc1N....
11 4KD1 - 1QK C21 H29 N6 O2 CCc1cnn2c1....
12 3LE6 ic50 = 0.035 uM 2BZ C17 H10 Cl N5 O2 Cc1c-2nc(c....
13 2VTI ic50 = 0.66 uM LZ3 C14 H12 N4 O3 S c1ccc2c(c1....
14 3LFS Ki = 2.5 uM A07 C17 H16 Cl N3 O CCCC(=O)Nc....
15 1PXI - CK1 C8 H5 Cl2 N3 S c1cnc(nc1c....
16 4LYN - 1YG C20 H23 N3 O2 S2 C[C@@H](c1....
17 1YKR ic50 = 0.56 uM 628 C20 H14 Cl2 N4 O3 S c1cc(c(c(c....
18 1PXN Ki = 0.07 uM CK6 C15 H15 N5 O S Cc1c(sc(n1....
19 2R3J ic50 = 10 nM SCJ C18 H14 Br N5 c1ccc(cc1)....
20 6Q3F - HEW C5 H5 Br N2 c1cnc(cc1B....
21 3IG7 ic50 = 9 nM EFP C18 H22 N4 O3 CC(=O)NC1C....
22 2VTS ic50 = 0.03 uM LZC C16 H23 N7 CC(C)Nc1cc....
23 1P2A ic50 = 12 nM 5BN C17 H15 F N4 O c1cc([nH]c....
24 2BHE ic50 = 1 uM BRY C16 H9 Br N2 O2 c1ccc2c(c1....
25 3UNK ic50 = 15 uM 0BY C17 H13 Cl N4 O2 c1ccc(c(c1....
26 2VTQ ic50 = 0.14 uM LZA C16 H17 F2 N5 O2 c1cc(c(c(c....
27 2C68 ic50 = 1.8 uM CT6 C18 H15 Br N5 c1cc(cc(c1....
28 3TIZ - 3TI C17 H13 N O2 c1ccc2c(c1....
29 3PXY ic50 = 5.9 uM JWS C10 H11 N5 O2 COc1ccc(c(....
30 2R3M ic50 = 10 nM SCX C19 H17 F2 N7 CCc1cnn2c1....
31 6HOT - CIY C10 H10 O3 COc1cc(ccc....
32 5ORJ - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
33 3MB6 ic50 = 100 nM 01I C16 H8 O6 c1cc2c(cc(....
34 5M4F - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
35 6A1C - 9NX C17 H15 Br N4 O2 S COc1cc(c(c....
36 6EHU - B5E C25 H24 F3 N3 CCc1ccccc1....
37 5CVH - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
38 3BQC ic50 ~ 2 uM EMO C15 H10 O5 Cc1cc2c(c(....
39 6L22 - E3U C16 H12 O6 c1cc(c(c2c....
40 5N9K Ki = 0.46 nM 8QK C20 H13 Cl2 N O4 COc1ccc(cc....
41 5OTQ - AUH C25 H27 N3 O CCc1ccccc1....
42 5CU2 - 54G C8 H8 O3 Cc1ccc(c(c....
43 5MO5 - 4IH C17 H21 Cl N2 O2 S CS(=O)(=O)....
44 5M4I - 7FC C16 H8 Cl2 O5 c1cc(ccc1C....
45 5MP8 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
46 6HOR - GJK C11 H12 O3 CC(=O)/C=C....
47 4UZH ic50 = 9800 nM JVE C15 H13 F N4 O c1ccc(c(c1....
48 6R49 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
49 6R4A - JRT C17 H17 N3 O c1ccc(cc1)....
50 5OS1 Kd = 494 uM A7H C10 H11 N O S CCOc1ccc2c....
51 2C6E - HPM C28 H31 N7 O4 COc1cc2c(c....
52 3H0Y ic50 = 0.006 uM 48B C23 H17 Cl F N5 O2 c1ccc(c(c1....
53 4B0G ic50 = 0.015 uM VEK C19 H21 Br N8 O Cc1cc(no1)....
54 4JBP ic50 = 41 nM YPH C34 H36 N6 O4 c1ccc(cc1)....
55 3H10 - 97B C30 H25 Cl F2 N6 O CN1CCN(CC1....
56 6VPM - MLA C3 H4 O4 C(C(=O)O)C....
57 5Y9M - NIO C6 H5 N O2 c1cc(cnc1)....
58 7A1B ic50 = 2.36 uM QXW C5 H2 Br2 N4 c1c2c(nc(c....
59 7A2H - QX2 C6 H2 Br3 N3 c1[nH]c2c(....
60 1M2P - HNA C14 H7 N O6 c1cc2c(c(c....
61 1LPU - BEN C7 H8 N2 [H]/N=C(c1....
62 2QC6 ic50 = 0.1 uM G12 C10 H6 Br2 O3 CC1=C(C(=O....
63 4ANM ic50 = 28 nM WUL C15 H14 Br N3 O3 c1cc2c(cc1....
64 1DAW - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
65 4RLK - E91 C21 H14 N2 O2 c1ccc2c(c1....
66 2OXD - K32 C7 H2 Br4 N2 O c12c(c(c(c....
67 1JKL - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
68 3F5G - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
69 5AUZ ic50 = 98 uM GEN C15 H10 O5 c1cc(ccc1C....
70 4FG9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
71 5L2T - 6ZZ C23 H30 N8 O CN(C)C(=O)....
72 3GC0 - AMP C10 H14 N5 O7 P c1nc(c2c(n....
73 3MFU - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
74 3C0H - AMP C10 H14 N5 O7 P c1nc(c2c(n....
75 3C0I - 3AM C10 H14 N5 O7 P c1nc(c2c(n....
76 3MFS - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
77 5OMY - 9YE C23 H25 N O3 CC(C)n1c2c....
78 2YAB - AMP C10 H14 N5 O7 P c1nc(c2c(n....
79 2YAA - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
80 4JR7 - GNP C10 H17 N6 O13 P3 c1nc2c(n1[....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: 54G; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 54G 1 1
2 GTQ 0.485714 0.909091
3 3R6 0.45 0.807692
4 MCT 0.424242 0.695652
5 N0D 0.411765 0.636364
Ligand no: 2; Ligand: 551; Similar ligands found: 8
No: Ligand ECFP6 Tc MDL keys Tc
1 551 1 1
2 KXZ 0.757143 0.907407
3 54R 0.720588 0.777778
4 4IH 0.625 0.605634
5 C98 0.602273 0.859649
6 YRA 0.571429 0.740741
7 54P 0.571429 0.654545
8 54S 0.446809 0.842105
Similar Ligands (3D)
Ligand no: 1; Ligand: 54G; Similar ligands found: 1330
No: Ligand Similarity coefficient
1 6CS 1.0000
2 5M0 1.0000
3 5RG 1.0000
4 5MK 0.9983
5 9TZ 0.9965
6 SX1 0.9934
7 G3F 0.9800
8 8S0 0.9798
9 BGC 0.9785
10 4CS 0.9782
11 1P7 0.9779
12 GCS 0.9757
13 8GC 0.9737
14 SAL 0.9726
15 3NT 0.9718
16 BE2 0.9713
17 GYE 0.9709
18 3HB 0.9697
19 GAB 0.9695
20 C2U 0.9693
21 NMJ 0.9690
22 CWS 0.9681
23 3Z7 0.9680
24 JBE 0.9679
25 G5V 0.9672
26 0P6 0.9671
27 3U4 0.9667
28 FOT 0.9665
29 EYK 0.9664
30 WCE 0.9663
31 ES6 0.9659
32 HXX 0.9657
33 UNC 0.9655
34 GLC 0.9654
35 3Z8 0.9651
36 KUF 0.9650
37 4SV 0.9647
38 3BZ 0.9645
39 IJZ 0.9637
40 3DO 0.9636
41 53C 0.9635
42 LGC 0.9634
43 BRT 0.9634
44 OW4 0.9632
45 5HN 0.9632
46 3OC 0.9630
47 OVV 0.9625
48 JKE 0.9623
49 3AB 0.9623
50 DBX 0.9619
51 5B1 0.9618
52 1DW 0.9614
53 AHR 0.9609
54 3MB 0.9609
55 5OB 0.9597
56 OVM 0.9592
57 HJP 0.9591
58 E7Z 0.9584
59 8CM 0.9580
60 DIU 0.9579
61 KBB 0.9577
62 4NC 0.9572
63 Q6T 0.9571
64 7NI 0.9570
65 DBJ 0.9566
66 7WV 0.9566
67 9MG 0.9566
68 4Z4 0.9564
69 IP0 0.9564
70 4M4 0.9562
71 4ZC 0.9562
72 XYP 0.9558
73 EA1 0.9557
74 RM1 0.9555
75 6M9 0.9555
76 SVN 0.9554
77 1WD 0.9551
78 5RN 0.9550
79 EUG 0.9545
80 VNJ 0.9545
81 V55 0.9541
82 GAL 0.9538
83 H42 0.9537
84 I3A 0.9536
85 COU 0.9536
86 MWP 0.9532
87 1P3 0.9529
88 F0J 0.9528
89 M0Q 0.9528
90 XX2 0.9527
91 2AQ 0.9524
92 1LQ 0.9524
93 7VS 0.9523
94 42A 0.9523
95 LZM 0.9519
96 OCH 0.9514
97 KBG 0.9511
98 HHA 0.9511
99 1NP 0.9510
100 G6D 0.9509
101 4FS 0.9508
102 HLZ 0.9507
103 0RW 0.9507
104 3F0 0.9507
105 7HQ 0.9505
106 9EW 0.9505
107 6M4 0.9504
108 Q88 0.9498
109 03V 0.9494
110 JB5 0.9494
111 ASC 0.9493
112 1SQ 0.9493
113 25W 0.9492
114 F05 0.9491
115 P9P 0.9488
116 N5J 0.9488
117 4HM 0.9485
118 FE DB1 0.9484
119 ICO 0.9484
120 BDP 0.9481
121 KT7 0.9481
122 3HA 0.9478
123 42C 0.9476
124 ES5 0.9474
125 BZX 0.9474
126 2HQ 0.9470
127 JPZ 0.9467
128 IFL 0.9465
129 CWM 0.9465
130 LT2 0.9464
131 NOJ 0.9464
132 ES1 0.9462
133 GUN 0.9462
134 9DG 0.9462
135 DHB 0.9461
136 XAN 0.9461
137 AZA 0.9461
138 3SK 0.9461
139 ES0 0.9460
140 5IQ 0.9460
141 24W 0.9458
142 4YS 0.9457
143 B60 0.9457
144 DBH 0.9456
145 6LW 0.9454
146 5Q0 0.9453
147 L3Q 0.9452
148 12Q 0.9451
149 M2K 0.9450
150 3M0 0.9450
151 JBH 0.9448
152 86J 0.9448
153 QSB 0.9447
154 5NU 0.9446
155 G2F 0.9445
156 A7W 0.9443
157 HQT 0.9442
158 MYJ 0.9440
159 5H1 0.9439
160 9TW 0.9439
161 BZ3 0.9439
162 IV2 0.9439
163 LXC 0.9438
164 M1A 0.9438
165 IGA 0.9438
166 R8S 0.9437
167 VNL 0.9436
168 MEW 0.9436
169 ASO 0.9432
170 JBK 0.9432
171 GCU 0.9431
172 XYL 0.9431
173 AKH 0.9430
174 A2F 0.9430
175 OVP 0.9429
176 AZ8 0.9429
177 SOR 0.9428
178 329 0.9428
179 XQG 0.9428
180 14O 0.9428
181 ADZ 0.9428
182 5XC 0.9426
183 ADE 0.9426
184 CHB 0.9425
185 X09 0.9420
186 5SG 0.9420
187 141 0.9420
188 2D0 0.9419
189 4JT 0.9419
190 6MP 0.9419
191 5CU 0.9415
192 PDC 0.9415
193 FA0 0.9414
194 F60 0.9414
195 7B4 0.9411
196 6AP 0.9410
197 LCN 0.9407
198 HPA 0.9407
199 HQY 0.9407
200 INO 0.9406
201 QUZ 0.9406
202 N8Y 0.9405
203 LKA 0.9405
204 HH8 0.9403
205 APZ 0.9403
206 FRU 0.9403
207 F31 0.9402
208 DNF 0.9402
209 DOB 0.9398
210 39A 0.9395
211 KJH 0.9395
212 MRW 0.9392
213 4XH 0.9392
214 6PC 0.9392
215 NOY 0.9391
216 9DA 0.9391
217 5MB 0.9390
218 IFM 0.9389
219 93K 0.9389
220 1XN 0.9388
221 SHG 0.9387
222 1XM 0.9387
223 RB5 0.9386
224 NNO 0.9386
225 JAE 0.9386
226 FHB 0.9385
227 2HO 0.9385
228 6AI 0.9385
229 TTL 0.9385
230 M5K 0.9384
231 4A3 0.9381
232 9HX 0.9381
233 ES9 0.9380
234 IHB 0.9377
235 AJ2 0.9377
236 5MI 0.9376
237 PM6 0.9376
238 O72 0.9376
239 GRE 0.9376
240 3ID 0.9376
241 5QX 0.9375
242 C2A 0.9374
243 KJU 0.9373
244 NPY 0.9373
245 DIN 0.9372
246 4M0 0.9372
247 2K4 0.9370
248 AZG 0.9370
249 4HC 0.9370
250 GLT 0.9369
251 BP1 0.9369
252 3XX 0.9369
253 67N 0.9369
254 SHA 0.9368
255 PE0 0.9367
256 1PT 0.9366
257 MAQ 0.9365
258 3HM 0.9364
259 10L 0.9364
260 J9W 0.9363
261 ORO 0.9362
262 7W1 0.9360
263 7ZE 0.9359
264 7HP 0.9358
265 5WY 0.9358
266 FK1 0.9358
267 JLZ 0.9354
268 6M1 0.9354
269 5WV 0.9354
270 0W8 0.9353
271 DRL 0.9352
272 G3E 0.9352
273 NK 0.9351
274 R8V 0.9350
275 H4N 0.9350
276 GCB 0.9349
277 J9T 0.9349
278 XQ0 0.9349
279 11S 0.9347
280 15L 0.9347
281 Q24 0.9347
282 YH7 0.9347
283 BTE 0.9346
284 FBV 0.9345
285 ES4 0.9345
286 1LM 0.9345
287 BHA 0.9345
288 3PF 0.9344
289 AQO 0.9342
290 KKN 0.9341
291 BOA 0.9340
292 TIU 0.9340
293 SKA 0.9339
294 SRO 0.9338
295 DMD 0.9338
296 ISN 0.9334
297 EVA 0.9334
298 EXO 0.9333
299 5GU 0.9331
300 OXC 0.9330
301 M1E 0.9330
302 PXL 0.9329
303 DX4 0.9329
304 AW5 0.9328
305 3WA 0.9328
306 7WA 0.9327
307 51R 0.9326
308 RIB 0.9325
309 8WT 0.9322
310 173 0.9322
311 ALL 0.9321
312 32X 0.9321
313 T9G 0.9321
314 60P 0.9320
315 6F0 0.9320
316 F5B 0.9320
317 ADK 0.9320
318 2CK 0.9319
319 YQA 0.9318
320 FB1 0.9318
321 SWD 0.9318
322 2AL 0.9316
323 2ZV 0.9314
324 CFP 0.9314
325 MUA 0.9314
326 DOR 0.9313
327 5WX 0.9313
328 XLS 0.9312
329 MO8 0.9309
330 GZL 0.9309
331 3MA 0.9308
332 5QY 0.9308
333 2H5 0.9307
334 M1Q 0.9307
335 OW7 0.9306
336 290 0.9303
337 286 0.9301
338 495 0.9301
339 3IT 0.9300
340 JZ3 0.9299
341 HZQ 0.9298
342 XXR 0.9298
343 GIF 0.9297
344 YCP 0.9297
345 NCA 0.9296
346 2MN 0.9295
347 BEZ 0.9294
348 KYD 0.9293
349 GLA 0.9292
350 LSA 0.9290
351 FEH 0.9288
352 WOO 0.9287
353 DFB 0.9287
354 8ZE 0.9285
355 MT0 0.9284
356 SWA 0.9283
357 FUL 0.9282
358 BEN 0.9282
359 23A 0.9281
360 MR1 0.9281
361 BMA 0.9281
362 KOJ 0.9280
363 2ZQ 0.9280
364 8EZ 0.9280
365 IPB 0.9279
366 F12 0.9278
367 7MU 0.9278
368 AL0 0.9277
369 NDM 0.9277
370 GIO 0.9277
371 NIO 0.9276
372 BCU 0.9275
373 UAN 0.9275
374 AZ9 0.9273
375 II6 0.9272
376 D1X 0.9272
377 S76 0.9272
378 4MU 0.9271
379 OMD 0.9269
380 34D 0.9268
381 PD2 0.9267
382 N2I 0.9266
383 DHK 0.9266
384 2DR 0.9266
385 VGD 0.9266
386 FBW 0.9266
387 SJ5 0.9265
388 0F9 0.9263
389 SYG 0.9262
390 ES7 0.9261
391 6GU 0.9260
392 M6N 0.9260
393 SXS 0.9259
394 0CU 0.9259
395 IPZ 0.9258
396 7W4 0.9257
397 DHQ 0.9256
398 NID 0.9256
399 PZA 0.9256
400 2XX 0.9255
401 NFQ 0.9253
402 OAA 0.9253
403 TAR 0.9252
404 2EC 0.9252
405 KJY 0.9250
406 GDE 0.9250
407 92K 0.9249
408 HQD 0.9249
409 NBZ 0.9248
410 FH2 0.9247
411 R8A 0.9247
412 FYU 0.9247
413 CN0 0.9246
414 JFJ 0.9242
415 D48 0.9242
416 NCD 0.9242
417 XCZ 0.9241
418 MWM 0.9241
419 BHO 0.9241
420 QWN 0.9240
421 SE2 0.9240
422 MLT 0.9240
423 4XR 0.9240
424 GBD 0.9239
425 HIO 0.9239
426 OXZ 0.9238
427 82I 0.9238
428 SYV 0.9238
429 MXN 0.9235
430 1AL 0.9234
431 RNT 0.9233
432 8NY 0.9232
433 ZWZ 0.9232
434 1P8 0.9232
435 TLA 0.9231
436 GCW 0.9231
437 ES2 0.9230
438 7N0 0.9228
439 SVD 0.9227
440 TH7 0.9227
441 QAT 0.9225
442 INE 0.9223
443 CTS 0.9222
444 2CQ 0.9222
445 RSF 0.9222
446 4ME 0.9221
447 FBB 0.9221
448 37T 0.9221
449 SS1 0.9221
450 MNN 0.9220
451 SKM 0.9219
452 GAG 0.9219
453 JZ1 0.9219
454 J5I 0.9218
455 7ME 0.9217
456 FDK 0.9217
457 2LP 0.9217
458 1DJ 0.9216
459 BAM 0.9216
460 DIE 0.9216
461 URC 0.9216
462 C2Y 0.9215
463 NIZ 0.9214
464 2LY 0.9213
465 JA8 0.9213
466 O7U 0.9213
467 BK9 0.9212
468 AGK 0.9212
469 RXA 0.9211
470 2YU 0.9210
471 HQ9 0.9210
472 3FH 0.9210
473 24B 0.9210
474 0R0 0.9209
475 3MG 0.9208
476 1LN 0.9208
477 GJS 0.9207
478 4AA 0.9207
479 1WG 0.9207
480 PYQ 0.9206
481 XYS 0.9206
482 1GN 0.9205
483 5RO 0.9205
484 ET2 0.9205
485 4ZE 0.9205
486 JUG 0.9204
487 CTL 0.9204
488 GM7 0.9203
489 RAM 0.9203
490 EQT 0.9203
491 G1O 0.9201
492 HX3 0.9200
493 X05 0.9199
494 UNU 0.9199
495 069 0.9197
496 DPZ 0.9197
497 FP1 0.9197
498 GZ8 0.9196
499 5JC 0.9196
500 45L 0.9195
501 QOS 0.9195
502 8G0 0.9194
503 RNS 0.9194
504 DEN 0.9193
505 SRT 0.9192
506 X6X 0.9192
507 HMU 0.9191
508 BEA 0.9191
509 5AC 0.9191
510 NDH 0.9190
511 7VJ 0.9190
512 HH5 0.9190
513 Z5P 0.9189
514 0N7 0.9188
515 BSX 0.9187
516 36R 0.9186
517 ZXD 0.9186
518 12M 0.9184
519 PBC 0.9184
520 B55 0.9184
521 QSC 0.9183
522 TM7 0.9183
523 GOX 0.9182
524 MZG 0.9182
525 QPR 0.9181
526 ABV 0.9180
527 2AK 0.9180
528 HMH 0.9180
529 92P 0.9179
530 LMR 0.9177
531 CLW 0.9177
532 URF 0.9177
533 XM0 0.9176
534 AZF 0.9175
535 QXW 0.9175
536 BR9 0.9175
537 K2T 0.9174
538 MAN 0.9173
539 QAS 0.9173
540 150 0.9173
541 091 0.9173
542 NTM 0.9171
543 AJV 0.9170
544 JND 0.9170
545 47J 0.9169
546 0LH 0.9169
547 LDP 0.9169
548 QSH 0.9169
549 2ZM 0.9168
550 A1U 0.9168
551 BTY 0.9167
552 2AC 0.9167
553 BE7 0.9166
554 LFR 0.9166
555 5JQ 0.9166
556 NQ 0.9165
557 BCP 0.9165
558 NTZ 0.9165
559 6VD 0.9165
560 XYD 0.9162
561 8TX 0.9162
562 261 0.9161
563 ISE 0.9161
564 2FY 0.9160
565 HLR 0.9160
566 3NY 0.9159
567 NTN 0.9158
568 UEG 0.9157
569 VOH 0.9157
570 HT4 0.9156
571 K5W 0.9156
572 XBZ 0.9155
573 J9Q 0.9154
574 23J 0.9154
575 VGL 0.9152
576 MWJ 0.9152
577 JZ9 0.9151
578 FDB 0.9150
579 GIV 0.9149
580 ODO 0.9149
581 IDM 0.9148
582 CFI 0.9148
583 AX7 0.9147
584 34A 0.9145
585 DYA 0.9145
586 RMN 0.9144
587 ISZ 0.9144
588 F9P 0.9143
589 H76 0.9143
590 IND 0.9143
591 AC0 0.9142
592 BZF 0.9142
593 0HO 0.9141
594 75K 0.9140
595 3DM 0.9140
596 G4D 0.9139
597 2MP 0.9139
598 UGC 0.9138
599 LRH 0.9138
600 5VM 0.9138
601 AH8 0.9137
602 GTR 0.9137
603 270 0.9137
604 TH0 0.9137
605 XAZ 0.9136
606 9PY 0.9133
607 ONR 0.9132
608 TSS 0.9132
609 OXQ 0.9132
610 27Y 0.9131
611 PA1 0.9127
612 TOF 0.9127
613 VK3 0.9126
614 BZI 0.9126
615 2PG 0.9125
616 XSP 0.9125
617 4HO 0.9125
618 PHT 0.9125
619 EKZ 0.9125
620 QDK 0.9123
621 4JJ 0.9123
622 149 0.9123
623 6NT 0.9123
624 F4Z 0.9123
625 M2H 0.9122
626 QX2 0.9122
627 4CL 0.9122
628 UFO 0.9122
629 X0V 0.9122
630 0JD 0.9122
631 3A9 0.9120
632 IFP 0.9120
633 WBU 0.9120
634 M1H 0.9120
635 O2A 0.9119
636 MS9 0.9118
637 4NG 0.9117
638 LNR 0.9117
639 YSO 0.9116
640 ROR 0.9115
641 FBM 0.9115
642 T6C 0.9115
643 JZ2 0.9114
644 4TU 0.9112
645 TSR 0.9111
646 QWW 0.9111
647 AFR 0.9111
648 HA7 0.9111
649 2A7 0.9109
650 F9Y 0.9109
651 43M 0.9109
652 DIG 0.9108
653 TEO 0.9108
654 7CZ 0.9107
655 H7Y 0.9106
656 B62 0.9106
657 PZI 0.9106
658 R9S 0.9105
659 KLW 0.9104
660 Y8I 0.9104
661 0FO 0.9104
662 SOE 0.9103
663 HY3 0.9103
664 JBQ 0.9102
665 URQ 0.9102
666 D07 0.9100
667 A29 0.9100
668 TDR 0.9100
669 284 0.9100
670 TTY 0.9098
671 MNM 0.9098
672 4FH 0.9098
673 2FG 0.9096
674 94B 0.9095
675 MBG 0.9094
676 5JL 0.9094
677 B53 0.9094
678 RSO 0.9094
679 GLF 0.9091
680 275 0.9091
681 LZ1 0.9091
682 L99 0.9090
683 2HU 0.9090
684 QBK 0.9090
685 4YO 0.9090
686 2MI 0.9089
687 ICP 0.9087
688 PYD 0.9087
689 NPO 0.9087
690 SS2 0.9087
691 0HN 0.9086
692 PXM 0.9085
693 JIF 0.9083
694 BNS 0.9083
695 SF9 0.9082
696 YIO 0.9082
697 GVH 0.9082
698 INS 0.9081
699 8OZ 0.9081
700 5UC 0.9081
701 0R1 0.9080
702 HNQ 0.9080
703 PCA 0.9079
704 FX1 0.9079
705 KDV 0.9079
706 97T 0.9079
707 OA3 0.9078
708 FBT 0.9078
709 TC7 0.9078
710 M58 0.9077
711 4SX 0.9077
712 0CT 0.9077
713 FCA 0.9076
714 6ME 0.9076
715 MZB 0.9076
716 5MH 0.9076
717 JXN 0.9076
718 ZZT 0.9076
719 DNC 0.9075
720 5CL 0.9075
721 R9Y 0.9074
722 DMJ 0.9074
723 PRZ 0.9074
724 MPI 0.9074
725 PRY 0.9073
726 TEP 0.9073
727 2TQ 0.9072
728 JZ4 0.9071
729 DQU 0.9071
730 MQN 0.9071
731 FGZ 0.9070
732 GAF 0.9069
733 2RH 0.9069
734 DA4 0.9068
735 7WR 0.9067
736 GV9 0.9067
737 RJY 0.9067
738 12B 0.9067
739 14J 0.9067
740 PAF 0.9066
741 1U6 0.9066
742 9FL 0.9065
743 A13 0.9064
744 1MC 0.9063
745 226 0.9061
746 RCO 0.9061
747 URA 0.9061
748 DGJ 0.9060
749 AEH 0.9059
750 TLD 0.9059
751 8IG 0.9058
752 45C 0.9057
753 4JP 0.9057
754 4JQ 0.9057
755 CRS 0.9057
756 7MH 0.9056
757 I1E 0.9056
758 8XQ 0.9056
759 FUC 0.9053
760 NVU 0.9053
761 FLV 0.9053
762 CFF 0.9053
763 3CH 0.9051
764 ASP 0.9051
765 CWJ 0.9050
766 FPK 0.9049
767 DTL 0.9048
768 HIS 0.9047
769 RD4 0.9046
770 4RW 0.9046
771 9KH 0.9046
772 8W9 0.9045
773 XIY 0.9041
774 MFB 0.9040
775 COI 0.9040
776 XHP 0.9040
777 948 0.9039
778 9RW 0.9039
779 PFB 0.9039
780 ABI 0.9037
781 DHS 0.9037
782 TRA 0.9037
783 NGO 0.9037
784 ADA 0.9037
785 ZZ3 0.9037
786 ARB 0.9035
787 2BG 0.9035
788 1F1 0.9034
789 0TU 0.9034
790 IF7 0.9032
791 RIP 0.9032
792 OTW 0.9031
793 P92 0.9031
794 LG3 0.9031
795 I2M 0.9030
796 XUL 0.9030
797 0TR 0.9029
798 PEY 0.9028
799 PHB 0.9028
800 44V 0.9027
801 GTZ 0.9027
802 3RK 0.9026
803 IT2 0.9026
804 LG5 0.9026
805 GOG 0.9024
806 4P0 0.9024
807 FA1 0.9023
808 28N 0.9023
809 CYT 0.9023
810 6R8 0.9022
811 94W 0.9022
812 I1N 0.9017
813 RPQ 0.9015
814 5NI 0.9014
815 DFU 0.9013
816 9R5 0.9013
817 CBF 0.9012
818 HY1 0.9011
819 F81 0.9009
820 SMN 0.9008
821 EOL 0.9007
822 BDF 0.9006
823 GOO 0.9006
824 TVP 0.9006
825 44W 0.9006
826 MT5 0.9005
827 35C 0.9005
828 463 0.9004
829 HA5 0.9004
830 KFH 0.9002
831 IPM 0.9002
832 Z82 0.9000
833 LYL 0.8999
834 VXX 0.8999
835 TFU 0.8998
836 39O 0.8998
837 26D 0.8997
838 D3M 0.8997
839 8H8 0.8996
840 CLZ 0.8994
841 GXL 0.8993
842 GT0 0.8992
843 PAB 0.8991
844 MRZ 0.8989
845 SF6 0.8989
846 CIT 0.8986
847 BVF 0.8986
848 M4E 0.8985
849 4XV 0.8985
850 AUD 0.8985
851 FPY 0.8984
852 B57 0.8983
853 AN0 0.8983
854 HQJ 0.8983
855 PBA 0.8981
856 AC6 0.8981
857 QIC 0.8981
858 PFL 0.8981
859 P3K 0.8979
860 3BU 0.8978
861 M0W 0.8976
862 MBD 0.8976
863 6NI 0.8975
864 0MK 0.8975
865 OHP 0.8975
866 6RQ 0.8975
867 TAG 0.8974
868 4AV 0.8973
869 9CA 0.8973
870 AMC 0.8972
871 4JO 0.8971
872 6JN 0.8971
873 SAF 0.8969
874 EDR 0.8968
875 FUF 0.8966
876 RBL 0.8964
877 5XB 0.8963
878 IDH 0.8963
879 MVN 0.8963
880 HBD 0.8963
881 PEZ 0.8963
882 SD4 0.8962
883 GXY 0.8959
884 3AL 0.8959
885 NEQ 0.8956
886 KIB 0.8955
887 8GF 0.8954
888 JAW 0.8953
889 N2Z 0.8951
890 AIN 0.8950
891 FUB 0.8950
892 FB2 0.8950
893 FUD 0.8949
894 JFD 0.8949
895 AS3 0.8949
896 HGQ 0.8948
897 7B3 0.8948
898 2A9 0.8945
899 FHN 0.8944
900 8HC 0.8944
901 KTA 0.8944
902 1AB 0.8943
903 PQ0 0.8943
904 B3R 0.8943
905 1M2 0.8942
906 5NE 0.8942
907 ZB1 0.8941
908 ZBT 0.8940
909 95Z 0.8940
910 0FK 0.8939
911 DEE 0.8938
912 IUR 0.8938
913 FCB 0.8938
914 XBT 0.8938
915 PMB 0.8937
916 EMZ 0.8936
917 8WO 0.8936
918 2FQ 0.8936
919 PHU 0.8934
920 PYG 0.8933
921 FAN 0.8932
922 JTH 0.8932
923 TPA 0.8932
924 4P5 0.8930
925 EJZ 0.8929
926 61M 0.8929
927 717 0.8929
928 HLD 0.8928
929 PBZ 0.8928
930 M3T 0.8928
931 826 0.8928
932 OTD 0.8927
933 1Y6 0.8927
934 3YP 0.8926
935 KP6 0.8925
936 H62 0.8924
937 4H2 0.8924
938 HEW 0.8924
939 HFB 0.8924
940 RM4 0.8922
941 EDG 0.8922
942 15N 0.8922
943 AHB 0.8921
944 NSP 0.8920
945 MSN 0.8920
946 EV0 0.8919
947 Q7A 0.8919
948 1IT 0.8918
949 7D2 0.8917
950 MB1 0.8916
951 ARA 0.8915
952 1X7 0.8912
953 N7P 0.8911
954 CIG 0.8911
955 SR1 0.8910
956 4XS 0.8910
957 GCO 0.8910
958 6UA 0.8909
959 4MA 0.8907
960 QX4 0.8907
961 PKU 0.8906
962 8EW 0.8906
963 PBE 0.8905
964 FQI 0.8903
965 TZE 0.8902
966 FBU 0.8902
967 ABE 0.8901
968 42J 0.8900
969 9KT 0.8899
970 MFU 0.8898
971 3FA 0.8898
972 GTL 0.8897
973 0GZ 0.8895
974 9FE 0.8895
975 8VN 0.8895
976 DQA 0.8895
977 ICT 0.8893
978 64K 0.8893
979 KPL 0.8893
980 MHK 0.8892
981 ICF 0.8892
982 GLY PRO 0.8891
983 13X 0.8891
984 PEP 0.8890
985 282 0.8890
986 CRN 0.8890
987 HKD 0.8889
988 1XX 0.8888
989 BR8 0.8888
990 30G 0.8888
991 PHH 0.8887
992 TBP 0.8887
993 MVL 0.8887
994 7MX 0.8887
995 TWO 0.8885
996 AMG 0.8884
997 5AN 0.8884
998 23W 0.8883
999 8GK 0.8883
1000 DQN 0.8882
1001 1DV 0.8882
1002 I6G 0.8881
1003 PEQ 0.8880
1004 JYB 0.8880
1005 2CM 0.8879
1006 PH2 0.8878
1007 7WG 0.8877
1008 KIA 0.8877
1009 MJ2 0.8876
1010 HTP 0.8876
1011 PRF 0.8875
1012 0FN 0.8874
1013 52C 0.8874
1014 DHR 0.8874
1015 GMN 0.8872
1016 3CE 0.8871
1017 PSV 0.8871
1018 HBA 0.8871
1019 QY9 0.8871
1020 AJY 0.8870
1021 XRG 0.8870
1022 GNL 0.8869
1023 2MY 0.8869
1024 209 0.8868
1025 TGX 0.8868
1026 JKZ 0.8868
1027 KDF 0.8867
1028 H33 0.8866
1029 3ZQ 0.8866
1030 DUB 0.8865
1031 BNT 0.8865
1032 N8P 0.8863
1033 Q02 0.8862
1034 PAC 0.8862
1035 4VY 0.8862
1036 174 0.8862
1037 AX2 0.8862
1038 1KP 0.8860
1039 SW7 0.8859
1040 C9E 0.8859
1041 51F 0.8859
1042 2C9 0.8859
1043 ZVO 0.8858
1044 3SL 0.8858
1045 HHR 0.8858
1046 FLM 0.8857
1047 LDR 0.8857
1048 HHQ 0.8856
1049 GCV 0.8854
1050 SYA 0.8853
1051 6MH 0.8853
1052 URP 0.8853
1053 RHU 0.8852
1054 FA3 0.8851
1055 15E 0.8849
1056 L5V 0.8846
1057 X8D 0.8846
1058 JB8 0.8845
1059 SYN 0.8845
1060 JDN 0.8845
1061 NK2 0.8845
1062 PCI 0.8845
1063 FBG 0.8844
1064 5ZE 0.8843
1065 APG 0.8842
1066 HBX 0.8842
1067 P72 0.8841
1068 UFV 0.8841
1069 QUS 0.8840
1070 M4T 0.8840
1071 ZYR 0.8840
1072 K3Q 0.8839
1073 GIM 0.8838
1074 2ZX 0.8836
1075 6OT 0.8836
1076 3MC 0.8835
1077 PY7 0.8835
1078 ZZ8 0.8834
1079 IBF 0.8834
1080 ABN 0.8833
1081 E1T 0.8833
1082 2AS 0.8833
1083 FPI 0.8833
1084 CKU 0.8831
1085 40O 0.8830
1086 6BL 0.8829
1087 9ZE 0.8827
1088 3AY 0.8826
1089 HSE 0.8825
1090 40E 0.8825
1091 SIF 0.8824
1092 LI6 0.8824
1093 1U1 0.8823
1094 BCF 0.8821
1095 4VP 0.8819
1096 ERH 0.8816
1097 1QP 0.8815
1098 JF2 0.8815
1099 BBF 0.8815
1100 K17 0.8815
1101 APY 0.8814
1102 HDH 0.8811
1103 IAC 0.8811
1104 9TY 0.8810
1105 JXW 0.8810
1106 2F6 0.8809
1107 3R9 0.8808
1108 YTB 0.8807
1109 ENL 0.8807
1110