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Receptor

PDB id	Resolution	Class	Description	Source	Keywords
5CU2	1.71 Å	EC: 2.7.11.1	CRYSTAL STRUCTURE OF CK2ALPHA WITH 2-HYDROXY-5-METHYLBENZOIC (METHYL 4-((3-(3-CHLORO-4-(PHENYL)BENZYLAMINO)PROPYL)AMINO)O XOBUTANOAT BOUND	HOMO SAPIENS	CK2ALPHA CK2A FRAGMENT BASED DRUG DISCOVERY HIGH CONCENTRSCREENING SELECTIVE ATP COMPETITIVE INHIBITORS SURFACE ENREDUCTION TRANSFERASE
Ref.:	A FRAGMENT-BASED APPROACH LEADING TO THE DISCOVERY NOVEL BINDING SITE AND THE SELECTIVE CK2 INHIBITOR BIOORG. MED. CHEM. V. 25 3471 2017

Ligand

Ligand	Chain:Residue	Validity	Ligand Warnings	Binding Data	Molecular Weight (Da)	Formula	SMILES
ACT	B:405; A:407; A:406;	Invalid; Invalid; Invalid;	none; none; none;	submit data	59.044	C2 H3 O2	CC(=O...
54G	B:403; A:404;	Valid; Valid;	none; none;	submit data	152.147	C8 H8 O3	Cc1cc...
PO4	B:404; A:405;	Invalid; Invalid;	none; none;	submit data	94.971	O4 P	[O-]P...
551	A:403; B:401; B:402; A:401; A:402;	Valid; Valid; Valid; Valid; Valid;	Atoms found LESS than expected: % Diff = 0.423; none; Atoms found LESS than expected: % Diff = 0.423; none; Atoms found LESS than expected: % Diff = 0.308;	submit data	374.861	C20 H23 Cl N2 O3	COC(=...

View in 3D viewer

90% Homology Family

Leader

PDB id	Resolution	Class	Description	Source	Keywords
5H8E	2.15 Å	EC: 2.7.11.1	CRYSTAL STRUCTURE OF CK2 WITH COMPOUND 7H	HOMO SAPIENS	KINASE INHIBITOR CK2 TRANSFERASE-TRANSFERASE INHIBITOR CO
Ref.:	POTENT AND SELECTIVE CK2 KINASE INHIBITORS WITH EFF WNT PATHWAY SIGNALING IN VIVO. ACS MED.CHEM.LETT. V. 7 300 2016

Members (123)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 133 families.
1	4FBX	-	0TJ GLY ASP ASP ASP ASP ASP	n/a	n/a
2	6L21	-	E3U	C16 H12 O6	c1cc(c(c2c....
3	5OUU	-	AWN	C22 H20 Cl N3	c1ccc(cc1)....
4	4RLL	-	E91	C21 H14 N2 O2	c1ccc2c(c1....
5	5CU4	Kd = 0.32 uM	54S	C26 H26 Cl N3 O4	c1ccc(cc1)....
6	6HOT	-	CIY	C10 H10 O3	COc1cc(ccc....
7	5ORJ	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
8	3MB6	ic50 = 100 nM	01I	C16 H8 O6	c1cc2c(cc(....
9	5M4F	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
10	6A1C	-	9NX	C17 H15 Br N4 O2 S	COc1cc(c(c....
11	6EHU	-	B5E	C25 H24 F3 N3	CCc1ccccc1....
12	5CVH	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
13	3BQC	ic50 ~ 2 uM	EMO	C15 H10 O5	Cc1cc2c(c(....
14	6L22	-	E3U	C16 H12 O6	c1cc(c(c2c....
15	5N9K	Ki = 0.46 nM	8QK	C20 H13 Cl2 N O4	COc1ccc(cc....
16	5OTQ	-	AUH	C25 H27 N3 O	CCc1ccccc1....
17	5CU2	-	54G	C8 H8 O3	Cc1ccc(c(c....
18	5MO5	-	4IH	C17 H21 Cl N2 O2 S	CS(=O)(=O)....
19	5M4I	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
20	5MP8	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
21	6HOR	-	GJK	C11 H12 O3	CC(=O)/C=C....
22	5MOV	-	HC4	C9 H8 O3	c1cc(ccc1C....
23	5MOH	-	YTX	C9 H10 O4	COc1cc(ccc....
24	6JWA	ic50 = 10.9 uM	5ID	C11 H13 I N4 O4	c1c(c2c(nc....
25	6HNW	ic50 = 200 nM	CUE	C15 H8 O5	c1cc2c(cc1....
26	5CSH	Kd = 270 uM	54E	C13 H12 Cl N	c1ccc(cc1)....
27	7A49	ic50 = 3.26 uM	QWN	C5 H2 Br Cl N4	c1c2c(nc(c....
28	5OTL	-	AQT	C25 H26 Cl N3 O	CCc1ccccc1....
29	5ORK	Kd = 234 uM	A4T	C13 H11 Cl F N	c1ccc(c(c1....
30	7A4B	ic50 = 2.56 uM	QXW	C5 H2 Br2 N4	c1c2c(nc(c....
31	3OWL	ic50 = 0.67 uM	19E	C16 H11 Cl N2 O	Cc1cnc(c2c....
32	5OYF	-	B4Q	C25 H27 N3	CCc1ccccc1....
33	5H8G	Kd = 48.2 pM	5Y4	C23 H29 N9 O	CC(=O)Nc1c....
34	5OS7	-	A8Q	C16 H19 Cl N	CC(C)c1ccc....
35	6YPJ	-	P5W	C16 H12 N2 O2 S	c1ccc(cc1)....
36	5OTZ	Kd = 6.5 uM	AUT	C15 H15 Cl2 N	CCc1ccccc1....
37	6HOQ	-	FER	C10 H10 O4	COc1cc(ccc....
38	5OUM	-	AVK	C18 H18 Cl N3	c1ccc(cc1)....
39	5B0X	ic50 = 0.02 uM	HCK	C18 H14 N2 O4 S	COc1ccc(cc....
40	5MO8	Kd = 1.64 uM	C98	C26 H26 Cl N3 O4	c1ccc(cc1)....
41	6RCB	ic50 = 0.33 uM	JYZ	C17 H14 N2 O4	COc1cc(ccc....
42	6HME	-	FXB	C21 H21 N O3	CC(C)n1c2c....
43	6HOP	-	FER	C10 H10 O4	COc1cc(ccc....
44	5OTO	-	AQW	C24 H23 Cl2 N3	CCc1ccccc1....
45	3AT4	Kd = 2.26 nM	CCK	C20 H20 N6 O2	CC(C)Nc1cc....
46	3OWJ	Ki = 0.86 uM	1EL	C17 H14 N2 O2	Cc1c2c(c(c....
47	6RFF	ic50 = 0.37 uM	K1B	C12 H6 Br N5 O4 S	c1cc(c(cc1....
48	6EII	-	B5W	C22 H23 Cl N	c1ccc(cc1)....
49	5CU0	-	54R	C18 H21 Cl N2 O	CC(=O)NCCC....
50	5H8E	Kd = 6.33 pM	5Y3	C21 H25 N9 O	CC(=O)Nc1c....
51	5OWH	-	B0K	C10 H9 Br4 N3	c1nc2c(n1C....
52	6L1Z	-	E3U	C16 H12 O6	c1cc(c(c2c....
53	3WAR	-	NIO	C6 H5 N O2	c1cc(cnc1)....
54	5MOE	Kd = 520 uM	OQC	C11 H10 Cl N O	c1cc(c(cc1....
55	5OUE	-	AVZ	C18 H19 Cl N3	c1ccc(cc1)....
56	5MOD	Kd = 300 uM	86L	C10 H14 Cl N O	CC(C)Oc1cc....
57	6RB1	ic50 = 1.37 uM	JWQ	C14 H9 F3 N4 O3 S	COc1cc(ccc....
58	6TEI	-	N4N	C15 H11 N3 O2 S	c1ccnc(c1)....
59	5OWL	-	B0K	C10 H9 Br4 N3	c1nc2c(n1C....
60	6HBN	-	FXB	C21 H21 N O3	CC(C)n1c2c....
61	5CU3	Kd = 0.32 uM	54S	C26 H26 Cl N3 O4	c1ccc(cc1)....
62	5OTR	-	AU8	C13 H12 Cl2 N	c1ccc(cc1)....
63	4KWP	Ki = 0.04 uM	EXX	C12 H10 Br4 N2 O3	c1nc2c(n1[....
64	5OSL	-	A9K	C13 H12 Cl N O	c1ccc(c(c1....
65	5N9N	Ki = 0.41 nM	KC5	C20 H15 Cl2 N O4	COc1ccc(cc....
66	5CSP	Kd = 58 uM	54G	C8 H8 O3	Cc1ccc(c(c....
67	5CTP	-	54R	C18 H21 Cl N2 O	CC(=O)NCCC....
68	5MOW	-	BR9	C5 H6 Br N3	c1c(cnc(c1....
69	4UB7	Ki = 2.5 nM	3G5	C16 H8 Br2 O5	c1cc(ccc1C....
70	5MMF	-	JMB	C16 H19 Cl N	CCC[NH2+]C....
71	5OTH	-	AQ8	C25 H26 Cl N3 O	CCc1ccccc1....
72	1PJK	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
73	6YPK	-	GDP	C10 H15 N5 O11 P2	c1nc2c(n1[....
74	3NSZ	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
75	5OTI	-	AOK	C25 H26 Cl N3	CCc1ccccc1....
76	3AXW	-	TID	C9 H7 N3 O2 S	c1cc(ccc1c....
77	5MO6	-	KXZ	C19 H21 Cl N2 O3	c1ccc(cc1)....
78	2PVR	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
79	3C13	-	EMO	C15 H10 O5	Cc1cc2c(c(....
80	5CS6	Kd = 630 uM	K82	C10 H14 Cl N O	CCCOc1ccc(....
81	6YPH	-	N5Q	C20 H14 N2 O3 S	c1ccc2cc(c....
82	3PE2	Ki = 0.175 nM	E1B	C20 H12 N4 O2	C#Cc1cccc(....
83	5CT0	-	54P	C16 H18 Cl N O	c1ccc(cc1)....
84	6RCM	ic50 = 0.36 uM	K0N	C17 H18 N4 O3 S	CC(C)(C)c1....
85	5CU6	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
86	5M4C	-	7EY	C16 H14 N2 O2 S2	Cc1ccc(cc1....
87	6SPX	ic50 = 44 uM	DAS ASP ASP ASP ASP ASP LYS 9AB	n/a	n/a
88	5MO7	-	YRA	C16 H17 Cl N2 O	c1ccc(cc1)....
89	5N9L	Ki = 15 nM	8QH	C20 H15 Cl2 N O3	Cc1ccc(cc1....
90	5OT5	-	AWK	C25 H26 Cl N3	CCc1ccccc1....
91	3OWK	ic50 = 1.5 uM	18E	C16 H11 Cl N2 O	Cc1cnc(c2c....
92	5MMR	-	H83	C17 H21 Cl N2	c1ccc(cc1)....
93	5MPJ	-	J2P	C15 H17 Cl N	CC[NH2+]Cc....
94	5OQU	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
95	6GIH	-	EZN	C15 H13 Cl N2	c1cc(c2cc[....
96	6RFE	ic50 = 0.28 uM	K0Z	C13 H9 Br N4 O3 S	COc1cc(ccc....
97	6YPG	-	N5Q	C20 H14 N2 O3 S	c1ccc2cc(c....
98	5CSV	-	GAB	C7 H7 N O2	c1cc(cc(c1....
99	5MOT	-	HBD	C7 H7 N O2	c1cc(ccc1C....
100	3R0T	ic50 = 0.91 nM	FU9	C22 H16 F3 N5 O2	c1cc(cc(c1....
101	3PE1	Ki = 0.223 nM	3NG	C19 H12 Cl N3 O2	c1cc(cc(c1....
102	3JUH	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
103	5CLP	-	42J	C8 H9 Cl2 N	c1cc(c(cc1....
104	5ORH	Kd = 41 uM	A4N	C14 H14 Cl N	Cc1ccccc1c....
105	3H30	Ki = 29.2 uM	RFZ	C12 H12 Cl2 N2 O4	c1c2c(cc(c....
106	2ZJW	Ki = 0.02 uM	REF	C14 H6 O8	c1c2c-3c(c....
107	6HOU	-	V55	C8 H8 O3	COc1cc(ccc....
108	7A4C	ic50 = 3.82 uM	QWW	C5 H Br3 N4	c12c(c(c(n....
109	6YPN	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
110	5OSZ	-	AHK	C24 H25 Cl N3	CCc1ccccc1....
111	4GRB	ic50 = 17 nM	0XG	C19 H18 N4 O4 S	CN(C)C(=O)....
112	5OT6	-	AJK	C19 H20 Cl N2	c1ccc(cc1)....
113	6EHK	-	AUW	C24 H23 Cl2 N3	CCc1ccccc1....
114	6L24	-	E3U	C16 H12 O6	c1cc(c(c2c....
115	3MB7	ic50 = 200 nM	14I	C16 H8 O6	c1cc2c(cc(....
116	5OS8	-	J27	C14 H14 Cl F N	Cc1cc(ccc1....
117	5OTY	-	AUW	C24 H23 Cl2 N3	CCc1ccccc1....
118	5OTD	-	AOW	C24 H24 Cl N4 O2	CCc1ccccc1....
119	6GMD	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
120	5CVF	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
121	6HNY	-	GHT	C19 H19 N O4	CN1CCc2cc(....
122	5CX9	-	551	C20 H23 Cl N2 O3	COC(=O)CC(....
123	5OUL	-	AWE	C13 H11 Cl F N	c1cc(cc(c1....

70% Homology Family (183)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 101 families.
1	4FBX	-	0TJ GLY ASP ASP ASP ASP ASP	n/a	n/a
2	6L21	-	E3U	C16 H12 O6	c1cc(c(c2c....
3	5OUU	-	AWN	C22 H20 Cl N3	c1ccc(cc1)....
4	4RLL	-	E91	C21 H14 N2 O2	c1ccc2c(c1....
5	5CU4	Kd = 0.32 uM	54S	C26 H26 Cl N3 O4	c1ccc(cc1)....
6	6HOT	-	CIY	C10 H10 O3	COc1cc(ccc....
7	5ORJ	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
8	3MB6	ic50 = 100 nM	01I	C16 H8 O6	c1cc2c(cc(....
9	5M4F	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
10	6A1C	-	9NX	C17 H15 Br N4 O2 S	COc1cc(c(c....
11	6EHU	-	B5E	C25 H24 F3 N3	CCc1ccccc1....
12	5CVH	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
13	3BQC	ic50 ~ 2 uM	EMO	C15 H10 O5	Cc1cc2c(c(....
14	6L22	-	E3U	C16 H12 O6	c1cc(c(c2c....
15	5N9K	Ki = 0.46 nM	8QK	C20 H13 Cl2 N O4	COc1ccc(cc....
16	5OTQ	-	AUH	C25 H27 N3 O	CCc1ccccc1....
17	5CU2	-	54G	C8 H8 O3	Cc1ccc(c(c....
18	5MO5	-	4IH	C17 H21 Cl N2 O2 S	CS(=O)(=O)....
19	5M4I	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
20	5MP8	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
21	6HOR	-	GJK	C11 H12 O3	CC(=O)/C=C....
22	5MOV	-	HC4	C9 H8 O3	c1cc(ccc1C....
23	5MOH	-	YTX	C9 H10 O4	COc1cc(ccc....
24	6JWA	ic50 = 10.9 uM	5ID	C11 H13 I N4 O4	c1c(c2c(nc....
25	6HNW	ic50 = 200 nM	CUE	C15 H8 O5	c1cc2c(cc1....
26	5CSH	Kd = 270 uM	54E	C13 H12 Cl N	c1ccc(cc1)....
27	7A49	ic50 = 3.26 uM	QWN	C5 H2 Br Cl N4	c1c2c(nc(c....
28	5OTL	-	AQT	C25 H26 Cl N3 O	CCc1ccccc1....
29	5ORK	Kd = 234 uM	A4T	C13 H11 Cl F N	c1ccc(c(c1....
30	7A4B	ic50 = 2.56 uM	QXW	C5 H2 Br2 N4	c1c2c(nc(c....
31	3OWL	ic50 = 0.67 uM	19E	C16 H11 Cl N2 O	Cc1cnc(c2c....
32	5OYF	-	B4Q	C25 H27 N3	CCc1ccccc1....
33	5H8G	Kd = 48.2 pM	5Y4	C23 H29 N9 O	CC(=O)Nc1c....
34	5OS7	-	A8Q	C16 H19 Cl N	CC(C)c1ccc....
35	6YPJ	-	P5W	C16 H12 N2 O2 S	c1ccc(cc1)....
36	5OTZ	Kd = 6.5 uM	AUT	C15 H15 Cl2 N	CCc1ccccc1....
37	6HOQ	-	FER	C10 H10 O4	COc1cc(ccc....
38	5OUM	-	AVK	C18 H18 Cl N3	c1ccc(cc1)....
39	5B0X	ic50 = 0.02 uM	HCK	C18 H14 N2 O4 S	COc1ccc(cc....
40	5MO8	Kd = 1.64 uM	C98	C26 H26 Cl N3 O4	c1ccc(cc1)....
41	6RCB	ic50 = 0.33 uM	JYZ	C17 H14 N2 O4	COc1cc(ccc....
42	6HME	-	FXB	C21 H21 N O3	CC(C)n1c2c....
43	6HOP	-	FER	C10 H10 O4	COc1cc(ccc....
44	5OTO	-	AQW	C24 H23 Cl2 N3	CCc1ccccc1....
45	3AT4	Kd = 2.26 nM	CCK	C20 H20 N6 O2	CC(C)Nc1cc....
46	3OWJ	Ki = 0.86 uM	1EL	C17 H14 N2 O2	Cc1c2c(c(c....
47	6RFF	ic50 = 0.37 uM	K1B	C12 H6 Br N5 O4 S	c1cc(c(cc1....
48	6EII	-	B5W	C22 H23 Cl N	c1ccc(cc1)....
49	5CU0	-	54R	C18 H21 Cl N2 O	CC(=O)NCCC....
50	5H8E	Kd = 6.33 pM	5Y3	C21 H25 N9 O	CC(=O)Nc1c....
51	5OWH	-	B0K	C10 H9 Br4 N3	c1nc2c(n1C....
52	6L1Z	-	E3U	C16 H12 O6	c1cc(c(c2c....
53	3WAR	-	NIO	C6 H5 N O2	c1cc(cnc1)....
54	5MOE	Kd = 520 uM	OQC	C11 H10 Cl N O	c1cc(c(cc1....
55	5OUE	-	AVZ	C18 H19 Cl N3	c1ccc(cc1)....
56	5MOD	Kd = 300 uM	86L	C10 H14 Cl N O	CC(C)Oc1cc....
57	6RB1	ic50 = 1.37 uM	JWQ	C14 H9 F3 N4 O3 S	COc1cc(ccc....
58	6TEI	-	N4N	C15 H11 N3 O2 S	c1ccnc(c1)....
59	5OWL	-	B0K	C10 H9 Br4 N3	c1nc2c(n1C....
60	6HBN	-	FXB	C21 H21 N O3	CC(C)n1c2c....
61	5CU3	Kd = 0.32 uM	54S	C26 H26 Cl N3 O4	c1ccc(cc1)....
62	5OTR	-	AU8	C13 H12 Cl2 N	c1ccc(cc1)....
63	4KWP	Ki = 0.04 uM	EXX	C12 H10 Br4 N2 O3	c1nc2c(n1[....
64	5OSL	-	A9K	C13 H12 Cl N O	c1ccc(c(c1....
65	5N9N	Ki = 0.41 nM	KC5	C20 H15 Cl2 N O4	COc1ccc(cc....
66	5CSP	Kd = 58 uM	54G	C8 H8 O3	Cc1ccc(c(c....
67	5CTP	-	54R	C18 H21 Cl N2 O	CC(=O)NCCC....
68	5MOW	-	BR9	C5 H6 Br N3	c1c(cnc(c1....
69	4UB7	Ki = 2.5 nM	3G5	C16 H8 Br2 O5	c1cc(ccc1C....
70	5MMF	-	JMB	C16 H19 Cl N	CCC[NH2+]C....
71	5OTH	-	AQ8	C25 H26 Cl N3 O	CCc1ccccc1....
72	1PJK	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
73	6YPK	-	GDP	C10 H15 N5 O11 P2	c1nc2c(n1[....
74	3NSZ	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
75	5OTI	-	AOK	C25 H26 Cl N3	CCc1ccccc1....
76	3AXW	-	TID	C9 H7 N3 O2 S	c1cc(ccc1c....
77	5MO6	-	KXZ	C19 H21 Cl N2 O3	c1ccc(cc1)....
78	2PVR	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
79	3C13	-	EMO	C15 H10 O5	Cc1cc2c(c(....
80	5CS6	Kd = 630 uM	K82	C10 H14 Cl N O	CCCOc1ccc(....
81	6YPH	-	N5Q	C20 H14 N2 O3 S	c1ccc2cc(c....
82	3PE2	Ki = 0.175 nM	E1B	C20 H12 N4 O2	C#Cc1cccc(....
83	5CT0	-	54P	C16 H18 Cl N O	c1ccc(cc1)....
84	6RCM	ic50 = 0.36 uM	K0N	C17 H18 N4 O3 S	CC(C)(C)c1....
85	5CU6	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
86	5M4C	-	7EY	C16 H14 N2 O2 S2	Cc1ccc(cc1....
87	6SPX	ic50 = 44 uM	DAS ASP ASP ASP ASP ASP LYS 9AB	n/a	n/a
88	5MO7	-	YRA	C16 H17 Cl N2 O	c1ccc(cc1)....
89	5N9L	Ki = 15 nM	8QH	C20 H15 Cl2 N O3	Cc1ccc(cc1....
90	5OT5	-	AWK	C25 H26 Cl N3	CCc1ccccc1....
91	3OWK	ic50 = 1.5 uM	18E	C16 H11 Cl N2 O	Cc1cnc(c2c....
92	5MMR	-	H83	C17 H21 Cl N2	c1ccc(cc1)....
93	5MPJ	-	J2P	C15 H17 Cl N	CC[NH2+]Cc....
94	5OQU	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
95	6GIH	-	EZN	C15 H13 Cl N2	c1cc(c2cc[....
96	6RFE	ic50 = 0.28 uM	K0Z	C13 H9 Br N4 O3 S	COc1cc(ccc....
97	6YPG	-	N5Q	C20 H14 N2 O3 S	c1ccc2cc(c....
98	5CSV	-	GAB	C7 H7 N O2	c1cc(cc(c1....
99	5MOT	-	HBD	C7 H7 N O2	c1cc(ccc1C....
100	3R0T	ic50 = 0.91 nM	FU9	C22 H16 F3 N5 O2	c1cc(cc(c1....
101	3PE1	Ki = 0.223 nM	3NG	C19 H12 Cl N3 O2	c1cc(cc(c1....
102	3JUH	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
103	5CLP	-	42J	C8 H9 Cl2 N	c1cc(c(cc1....
104	5ORH	Kd = 41 uM	A4N	C14 H14 Cl N	Cc1ccccc1c....
105	3H30	Ki = 29.2 uM	RFZ	C12 H12 Cl2 N2 O4	c1c2c(cc(c....
106	2ZJW	Ki = 0.02 uM	REF	C14 H6 O8	c1c2c-3c(c....
107	6HOU	-	V55	C8 H8 O3	COc1cc(ccc....
108	7A4C	ic50 = 3.82 uM	QWW	C5 H Br3 N4	c12c(c(c(n....
109	6YPN	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
110	5OSZ	-	AHK	C24 H25 Cl N3	CCc1ccccc1....
111	4GRB	ic50 = 17 nM	0XG	C19 H18 N4 O4 S	CN(C)C(=O)....
112	5OT6	-	AJK	C19 H20 Cl N2	c1ccc(cc1)....
113	6EHK	-	AUW	C24 H23 Cl2 N3	CCc1ccccc1....
114	6L24	-	E3U	C16 H12 O6	c1cc(c(c2c....
115	3MB7	ic50 = 200 nM	14I	C16 H8 O6	c1cc2c(cc(....
116	5OS8	-	J27	C14 H14 Cl F N	Cc1cc(ccc1....
117	5OTY	-	AUW	C24 H23 Cl2 N3	CCc1ccccc1....
118	5OTD	-	AOW	C24 H24 Cl N4 O2	CCc1ccccc1....
119	6GMD	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
120	5CVF	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
121	6HNY	-	GHT	C19 H19 N O4	CN1CCc2cc(....
122	5CX9	-	551	C20 H23 Cl N2 O3	COC(=O)CC(....
123	5OUL	-	AWE	C13 H11 Cl F N	c1cc(cc(c1....
124	6TEW	-	N5Q	C20 H14 N2 O3 S	c1ccc2cc(c....
125	5Y9M	-	NIO	C6 H5 N O2	c1cc(cnc1)....
126	7A1B	ic50 = 2.36 uM	QXW	C5 H2 Br2 N4	c1c2c(nc(c....
127	7A2H	-	QX2	C6 H2 Br3 N3	c1[nH]c2c(....
128	5M56	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
129	5M4U	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
130	6HMD	-	GDW	C21 H24 N2 O2	CCN(CC)CCn....
131	6HMQ	-	4B0	C9 H7 Br4 N3 O	C(Cn1c2c(c....
132	5OOI	-	9YE	C23 H25 N O3	CC(C)n1c2c....
133	7A1Z	ic50 = 3.38 uM	QWN	C5 H2 Br Cl N4	c1c2c(nc(c....
134	6TE2	-	N4N	C15 H11 N3 O2 S	c1ccnc(c1)....
135	6HMB	-	3NG	C19 H12 Cl N3 O2	c1cc(cc(c1....
136	7A22	ic50 = 1.98 uM	QWW	C5 H Br3 N4	c12c(c(c(n....
137	3OFM	-	4B0	C9 H7 Br4 N3 O	C(Cn1c2c(c....
138	6HMC	-	FXB	C21 H21 N O3	CC(C)n1c2c....
139	5YF9	-	NIO	C6 H5 N O2	c1cc(cnc1)....
140	6TGU	-	N92	C16 H11 Cl N2 O3 S	c1cc(ccc1c....
141	2PVH	Ki = 0.26 uM	P19	C17 H14 N6	c1ccc(cc1)....
142	1M2P	-	HNA	C14 H7 N O6	c1cc2c(c(c....
143	1LPU	-	BEN	C7 H8 N2	[H]/N=C(c1....
144	2QC6	ic50 = 0.1 uM	G12	C10 H6 Br2 O3	CC1=C(C(=O....
145	4ANM	ic50 = 28 nM	WUL	C15 H14 Br N3 O3	c1cc2c(cc1....
146	1DAW	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
147	4RLK	-	E91	C21 H14 N2 O2	c1ccc2c(c1....
148	2OXD	-	K32	C7 H2 Br4 N2 O	c12c(c(c(c....
149	2PVM	Ki = 0.36 uM	P29	C17 H15 N9	c1ccc(cc1)....
150	1J91	-	TBS	C6 H Br4 N3	c12c(c(c(c....
151	3FL5	-	TXQ	C14 H8 O6	c1cc(c(c2c....
152	3PWD	Ki = 0.22 uM	CZ0	C14 H9 N O5	CC1=CC(=O)....
153	3KXH	-	K66	C11 H9 Br4 N3 O2	CN(C)c1nc2....
154	4DGM	ic50 = 1.2 uM	AGI	C15 H10 O5	c1cc(ccc1C....
155	3PVG	-	K68	C9 H4 Br4 N2 O2	c1nc2c(n1C....
156	1ZOG	Ki = 0.07 uM	K37	C8 H4 Br4 N2 S	CSc1[nH]c2....
157	2PVJ	Ki = 0.005 uM	P44	C19 H21 N7	c1ccc(cc1)....
158	4DGN	ic50 = 0.35 uM	LU2	C15 H10 O6	c1cc(c(cc1....
159	1M2Q	-	MNX	C13 H7 N O6	c1cc(c2c(c....
160	2OXY	-	K17	C7 H2 Br4 N2	c1[nH]c2c(....
161	1M2R	-	MNY	C14 H10 N2 O4	c1cc(c2c(c....
162	3KXN	-	K8X	C7 H2 I4 N2	c1[nH]c2c(....
163	6QS5	ic50 = 0.57 uM	JGB	C10 H8 N2 O3	c1cc(c(cc1....
164	1ZOE	Ki = 0.04 uM	K25	C9 H7 Br4 N3	CN(C)c1[nH....
165	2PVL	Ki = 0.024 uM	P55	C18 H20 N8	CCN1CCN(CC....
166	1LP4	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
167	2PVN	Ki = 0.00035 uM	P63	C20 H16 N8 O	CC(=O)Nc1c....
168	3KXG	-	K6X	C7 H Br5 N2	c12c(c(c(c....
169	3BE9	Ki = 24 nM	P04	C19 H21 N7 O	c1cc2cc(c1....
170	2OXX	-	K22	C7 H2 Br4 N2 S	c12c(c(c(c....
171	3KXM	-	K74	C11 H9 Br4 N3 O S	CNC(=O)CSc....
172	1LR4	-	BEN	C7 H8 N2	[H]/N=C(c1....
173	1OM1	Ki = 0.17 uM	IQA	C17 H12 N2 O3	c1ccc2c(c1....
174	1ZOH	Ki = 0.1 uM	K44	C10 H7 Br4 N3	C[N@@]1CCn....
175	2PVK	Ki = 0.008 uM	P45	C19 H14 Cl N7	c1ccc(cc1)....
176	1DAY	-	GNP	C10 H17 N6 O13 P3	c1nc2c(n1[....
177	6KO6	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
178	6K3L	Kd = 60.1 nM	3NG	C19 H12 Cl N3 O2	c1cc(cc(c1....
179	6ISJ	-	3NG	C19 H12 Cl N3 O2	c1cc(cc(c1....
180	5OMY	-	9YE	C23 H25 N O3	CC(C)n1c2c....
181	6SPW	ic50 = 4.5 uM	DAS ASP ASP ASP ASP ASP LYS A0Z	n/a	n/a
182	5ONI	-	9YE	C23 H25 N O3	CC(C)n1c2c....
183	6XX7	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....

50% Homology Family (80)

No:	PDB id	Binding Data	Representative ligand	Formula	Smiles
The Class containing this family consists of a total of 8 families.
1	3PXQ	Kd = 37 uM	2AN	C16 H13 N O3 S	c1ccc(cc1)....
2	2R3N	ic50 = 70 nM	SCZ	C21 H19 N5	c1ccc(cc1)....
3	1H0V	-	UN4	C10 H12 N6 O2	c1[nH]c2c(....
4	4NJ3	Kd = 0.3 uM	2KD	C27 H21 Cl N2 O6	COC(=O)[C@....
5	1JSV	-	U55	C10 H11 N5 O2 S	c1cc(ccc1N....
6	1OIQ	ic50 = 2.9 uM	HDU	C14 H13 N5 O	Cc1c(n2ccc....
7	2W17	ic50 = 0.002 uM	I19	C24 H30 F N7 O	Cc1ncc(n1C....
8	2VTP	ic50 = 0.003 uM	LZ9	C17 H11 F3 N4 O2	c1cc(c(c(c....
9	1JVP	ic50 = 1.6 uM	LIG	C15 H11 N3	c1ccc-2c(c....
10	1FVT	-	106	C14 H11 Br N4 O3 S	c1cc(ccc1N....
11	4KD1	-	1QK	C21 H29 N6 O2	CCc1cnn2c1....
12	3LE6	ic50 = 0.035 uM	2BZ	C17 H10 Cl N5 O2	Cc1c-2nc(c....
13	2VTI	ic50 = 0.66 uM	LZ3	C14 H12 N4 O3 S	c1ccc2c(c1....
14	3LFS	Ki = 2.5 uM	A07	C17 H16 Cl N3 O	CCCC(=O)Nc....
15	1PXI	-	CK1	C8 H5 Cl2 N3 S	c1cnc(nc1c....
16	4LYN	-	1YG	C20 H23 N3 O2 S2	C[C@@H](c1....
17	1YKR	ic50 = 0.56 uM	628	C20 H14 Cl2 N4 O3 S	c1cc(c(c(c....
18	1PXN	Ki = 0.07 uM	CK6	C15 H15 N5 O S	Cc1c(sc(n1....
19	2R3J	ic50 = 10 nM	SCJ	C18 H14 Br N5	c1ccc(cc1)....
20	6Q3F	-	HEW	C5 H5 Br N2	c1cnc(cc1B....
21	3IG7	ic50 = 9 nM	EFP	C18 H22 N4 O3	CC(=O)NC1C....
22	2VTS	ic50 = 0.03 uM	LZC	C16 H23 N7	CC(C)Nc1cc....
23	1P2A	ic50 = 12 nM	5BN	C17 H15 F N4 O	c1cc([nH]c....
24	2BHE	ic50 = 1 uM	BRY	C16 H9 Br N2 O2	c1ccc2c(c1....
25	3UNK	ic50 = 15 uM	0BY	C17 H13 Cl N4 O2	c1ccc(c(c1....
26	2VTQ	ic50 = 0.14 uM	LZA	C16 H17 F2 N5 O2	c1cc(c(c(c....
27	2C68	ic50 = 1.8 uM	CT6	C18 H15 Br N5	c1cc(cc(c1....
28	3TIZ	-	3TI	C17 H13 N O2	c1ccc2c(c1....
29	3PXY	ic50 = 5.9 uM	JWS	C10 H11 N5 O2	COc1ccc(c(....
30	2R3M	ic50 = 10 nM	SCX	C19 H17 F2 N7	CCc1cnn2c1....
31	6HOT	-	CIY	C10 H10 O3	COc1cc(ccc....
32	5ORJ	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
33	3MB6	ic50 = 100 nM	01I	C16 H8 O6	c1cc2c(cc(....
34	5M4F	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
35	6A1C	-	9NX	C17 H15 Br N4 O2 S	COc1cc(c(c....
36	6EHU	-	B5E	C25 H24 F3 N3	CCc1ccccc1....
37	5CVH	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
38	3BQC	ic50 ~ 2 uM	EMO	C15 H10 O5	Cc1cc2c(c(....
39	6L22	-	E3U	C16 H12 O6	c1cc(c(c2c....
40	5N9K	Ki = 0.46 nM	8QK	C20 H13 Cl2 N O4	COc1ccc(cc....
41	5OTQ	-	AUH	C25 H27 N3 O	CCc1ccccc1....
42	5CU2	-	54G	C8 H8 O3	Cc1ccc(c(c....
43	5MO5	-	4IH	C17 H21 Cl N2 O2 S	CS(=O)(=O)....
44	5M4I	-	7FC	C16 H8 Cl2 O5	c1cc(ccc1C....
45	5MP8	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
46	6HOR	-	GJK	C11 H12 O3	CC(=O)/C=C....
47	4UZH	ic50 = 9800 nM	JVE	C15 H13 F N4 O	c1ccc(c(c1....
48	6R49	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
49	6R4A	-	JRT	C17 H17 N3 O	c1ccc(cc1)....
50	5OS1	Kd = 494 uM	A7H	C10 H11 N O S	CCOc1ccc2c....
51	2C6E	-	HPM	C28 H31 N7 O4	COc1cc2c(c....
52	3H0Y	ic50 = 0.006 uM	48B	C23 H17 Cl F N5 O2	c1ccc(c(c1....
53	4B0G	ic50 = 0.015 uM	VEK	C19 H21 Br N8 O	Cc1cc(no1)....
54	4JBP	ic50 = 41 nM	YPH	C34 H36 N6 O4	c1ccc(cc1)....
55	3H10	-	97B	C30 H25 Cl F2 N6 O	CN1CCN(CC1....
56	6VPM	-	MLA	C3 H4 O4	C(C(=O)O)C....
57	5Y9M	-	NIO	C6 H5 N O2	c1cc(cnc1)....
58	7A1B	ic50 = 2.36 uM	QXW	C5 H2 Br2 N4	c1c2c(nc(c....
59	7A2H	-	QX2	C6 H2 Br3 N3	c1[nH]c2c(....
60	1M2P	-	HNA	C14 H7 N O6	c1cc2c(c(c....
61	1LPU	-	BEN	C7 H8 N2	[H]/N=C(c1....
62	2QC6	ic50 = 0.1 uM	G12	C10 H6 Br2 O3	CC1=C(C(=O....
63	4ANM	ic50 = 28 nM	WUL	C15 H14 Br N3 O3	c1cc2c(cc1....
64	1DAW	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
65	4RLK	-	E91	C21 H14 N2 O2	c1ccc2c(c1....
66	2OXD	-	K32	C7 H2 Br4 N2 O	c12c(c(c(c....
67	1JKL	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
68	3F5G	-	ADP	C10 H15 N5 O10 P2	c1nc(c2c(n....
69	5AUZ	ic50 = 98 uM	GEN	C15 H10 O5	c1cc(ccc1C....
70	4FG9	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
71	5L2T	-	6ZZ	C23 H30 N8 O	CN(C)C(=O)....
72	3GC0	-	AMP	C10 H14 N5 O7 P	c1nc(c2c(n....
73	3MFU	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
74	3C0H	-	AMP	C10 H14 N5 O7 P	c1nc(c2c(n....
75	3C0I	-	3AM	C10 H14 N5 O7 P	c1nc(c2c(n....
76	3MFS	-	ANP	C10 H17 N6 O12 P3	c1nc(c2c(n....
77	5OMY	-	9YE	C23 H25 N O3	CC(C)n1c2c....
78	2YAB	-	AMP	C10 H14 N5 O7 P	c1nc(c2c(n....
79	2YAA	-	ATP	C10 H16 N5 O13 P3	c1nc(c2c(n....
80	4JR7	-	GNP	C10 H17 N6 O13 P3	c1nc2c(n1[....

Polypharmacology

Similar Ligands (2D)

Ligand no: 1; Ligand: 54G; Similar ligands found: 5

No:	Ligand	ECFP6 Tc	MDL keys Tc
1	54G	1	1
2	GTQ	0.485714	0.909091
3	3R6	0.45	0.807692
4	MCT	0.424242	0.695652
5	N0D	0.411765	0.636364

Ligand no: 2; Ligand: 551; Similar ligands found: 8

No:	Ligand	ECFP6 Tc	MDL keys Tc
1	551	1	1
2	KXZ	0.757143	0.907407
3	54R	0.720588	0.777778
4	4IH	0.625	0.605634
5	C98	0.602273	0.859649
6	YRA	0.571429	0.740741
7	54P	0.571429	0.654545
8	54S	0.446809	0.842105

Similar Ligands (3D)

Ligand no: 1; Ligand: 54G; Similar ligands found: 1330

No:	Ligand	Similarity coefficient
1	6CS	1.0000
2	5M0	1.0000
3	5RG	1.0000
4	5MK	0.9983
5	9TZ	0.9965
6	SX1	0.9934
7	G3F	0.9800
8	8S0	0.9798
9	BGC	0.9785
10	4CS	0.9782
11	1P7	0.9779
12	GCS	0.9757
13	8GC	0.9737
14	SAL	0.9726
15	3NT	0.9718
16	BE2	0.9713
17	GYE	0.9709
18	3HB	0.9697
19	GAB	0.9695
20	C2U	0.9693
21	NMJ	0.9690
22	CWS	0.9681
23	3Z7	0.9680
24	JBE	0.9679
25	G5V	0.9672
26	0P6	0.9671
27	3U4	0.9667
28	FOT	0.9665
29	EYK	0.9664
30	WCE	0.9663
31	ES6	0.9659
32	HXX	0.9657
33	UNC	0.9655
34	GLC	0.9654
35	3Z8	0.9651
36	KUF	0.9650
37	4SV	0.9647
38	3BZ	0.9645
39	IJZ	0.9637
40	3DO	0.9636
41	53C	0.9635
42	LGC	0.9634
43	BRT	0.9634
44	OW4	0.9632
45	5HN	0.9632
46	3OC	0.9630
47	OVV	0.9625
48	JKE	0.9623
49	3AB	0.9623
50	DBX	0.9619
51	5B1	0.9618
52	1DW	0.9614
53	AHR	0.9609
54	3MB	0.9609
55	5OB	0.9597
56	OVM	0.9592
57	HJP	0.9591
58	E7Z	0.9584
59	8CM	0.9580
60	DIU	0.9579
61	KBB	0.9577
62	4NC	0.9572
63	Q6T	0.9571
64	7NI	0.9570
65	DBJ	0.9566
66	7WV	0.9566
67	9MG	0.9566
68	4Z4	0.9564
69	IP0	0.9564
70	4M4	0.9562
71	4ZC	0.9562
72	XYP	0.9558
73	EA1	0.9557
74	RM1	0.9555
75	6M9	0.9555
76	SVN	0.9554
77	1WD	0.9551
78	5RN	0.9550
79	EUG	0.9545
80	VNJ	0.9545
81	V55	0.9541
82	GAL	0.9538
83	H42	0.9537
84	I3A	0.9536
85	COU	0.9536
86	MWP	0.9532
87	1P3	0.9529
88	F0J	0.9528
89	M0Q	0.9528
90	XX2	0.9527
91	2AQ	0.9524
92	1LQ	0.9524
93	7VS	0.9523
94	42A	0.9523
95	LZM	0.9519
96	OCH	0.9514
97	KBG	0.9511
98	HHA	0.9511
99	1NP	0.9510
100	G6D	0.9509
101	4FS	0.9508
102	HLZ	0.9507
103	0RW	0.9507
104	3F0	0.9507
105	7HQ	0.9505
106	9EW	0.9505
107	6M4	0.9504
108	Q88	0.9498
109	03V	0.9494
110	JB5	0.9494
111	ASC	0.9493
112	1SQ	0.9493
113	25W	0.9492
114	F05	0.9491
115	P9P	0.9488
116	N5J	0.9488
117	4HM	0.9485
118	FE DB1	0.9484
119	ICO	0.9484
120	BDP	0.9481
121	KT7	0.9481
122	3HA	0.9478
123	42C	0.9476
124	ES5	0.9474
125	BZX	0.9474
126	2HQ	0.9470
127	JPZ	0.9467
128	IFL	0.9465
129	CWM	0.9465
130	LT2	0.9464
131	NOJ	0.9464
132	ES1	0.9462
133	GUN	0.9462
134	9DG	0.9462
135	DHB	0.9461
136	XAN	0.9461
137	AZA	0.9461
138	3SK	0.9461
139	ES0	0.9460
140	5IQ	0.9460
141	24W	0.9458
142	4YS	0.9457
143	B60	0.9457
144	DBH	0.9456
145	6LW	0.9454
146	5Q0	0.9453
147	L3Q	0.9452
148	12Q	0.9451
149	M2K	0.9450
150	3M0	0.9450
151	JBH	0.9448
152	86J	0.9448
153	QSB	0.9447
154	5NU	0.9446
155	G2F	0.9445
156	A7W	0.9443
157	HQT	0.9442
158	MYJ	0.9440
159	5H1	0.9439
160	9TW	0.9439
161	BZ3	0.9439
162	IV2	0.9439
163	LXC	0.9438
164	M1A	0.9438
165	IGA	0.9438
166	R8S	0.9437
167	VNL	0.9436
168	MEW	0.9436
169	ASO	0.9432
170	JBK	0.9432
171	GCU	0.9431
172	XYL	0.9431
173	AKH	0.9430
174	A2F	0.9430
175	OVP	0.9429
176	AZ8	0.9429
177	SOR	0.9428
178	329	0.9428
179	XQG	0.9428
180	14O	0.9428
181	ADZ	0.9428
182	5XC	0.9426
183	ADE	0.9426
184	CHB	0.9425
185	X09	0.9420
186	5SG	0.9420
187	141	0.9420
188	2D0	0.9419
189	4JT	0.9419
190	6MP	0.9419
191	5CU	0.9415
192	PDC	0.9415
193	FA0	0.9414
194	F60	0.9414
195	7B4	0.9411
196	6AP	0.9410
197	LCN	0.9407
198	HPA	0.9407
199	HQY	0.9407
200	INO	0.9406
201	QUZ	0.9406
202	N8Y	0.9405
203	LKA	0.9405
204	HH8	0.9403
205	APZ	0.9403
206	FRU	0.9403
207	F31	0.9402
208	DNF	0.9402
209	DOB	0.9398
210	39A	0.9395
211	KJH	0.9395
212	MRW	0.9392
213	4XH	0.9392
214	6PC	0.9392
215	NOY	0.9391
216	9DA	0.9391
217	5MB	0.9390
218	IFM	0.9389
219	93K	0.9389
220	1XN	0.9388
221	SHG	0.9387
222	1XM	0.9387
223	RB5	0.9386
224	NNO	0.9386
225	JAE	0.9386
226	FHB	0.9385
227	2HO	0.9385
228	6AI	0.9385
229	TTL	0.9385
230	M5K	0.9384
231	4A3	0.9381
232	9HX	0.9381
233	ES9	0.9380
234	IHB	0.9377
235	AJ2	0.9377
236	5MI	0.9376
237	PM6	0.9376
238	O72	0.9376
239	GRE	0.9376
240	3ID	0.9376
241	5QX	0.9375
242	C2A	0.9374
243	KJU	0.9373
244	NPY	0.9373
245	DIN	0.9372
246	4M0	0.9372
247	2K4	0.9370
248	AZG	0.9370
249	4HC	0.9370
250	GLT	0.9369
251	BP1	0.9369
252	3XX	0.9369
253	67N	0.9369
254	SHA	0.9368
255	PE0	0.9367
256	1PT	0.9366
257	MAQ	0.9365
258	3HM	0.9364
259	10L	0.9364
260	J9W	0.9363
261	ORO	0.9362
262	7W1	0.9360
263	7ZE	0.9359
264	7HP	0.9358
265	5WY	0.9358
266	FK1	0.9358
267	JLZ	0.9354
268	6M1	0.9354
269	5WV	0.9354
270	0W8	0.9353
271	DRL	0.9352
272	G3E	0.9352
273	NK	0.9351
274	R8V	0.9350
275	H4N	0.9350
276	GCB	0.9349
277	J9T	0.9349
278	XQ0	0.9349
279	11S	0.9347
280	15L	0.9347
281	Q24	0.9347
282	YH7	0.9347
283	BTE	0.9346
284	FBV	0.9345
285	ES4	0.9345
286	1LM	0.9345
287	BHA	0.9345
288	3PF	0.9344
289	AQO	0.9342
290	KKN	0.9341
291	BOA	0.9340
292	TIU	0.9340
293	SKA	0.9339
294	SRO	0.9338
295	DMD	0.9338
296	ISN	0.9334
297	EVA	0.9334
298	EXO	0.9333
299	5GU	0.9331
300	OXC	0.9330
301	M1E	0.9330
302	PXL	0.9329
303	DX4	0.9329
304	AW5	0.9328
305	3WA	0.9328
306	7WA	0.9327
307	51R	0.9326
308	RIB	0.9325
309	8WT	0.9322
310	173	0.9322
311	ALL	0.9321
312	32X	0.9321
313	T9G	0.9321
314	60P	0.9320
315	6F0	0.9320
316	F5B	0.9320
317	ADK	0.9320
318	2CK	0.9319
319	YQA	0.9318
320	FB1	0.9318
321	SWD	0.9318
322	2AL	0.9316
323	2ZV	0.9314
324	CFP	0.9314
325	MUA	0.9314
326	DOR	0.9313
327	5WX	0.9313
328	XLS	0.9312
329	MO8	0.9309
330	GZL	0.9309
331	3MA	0.9308
332	5QY	0.9308
333	2H5	0.9307
334	M1Q	0.9307
335	OW7	0.9306
336	290	0.9303
337	286	0.9301
338	495	0.9301
339	3IT	0.9300
340	JZ3	0.9299
341	HZQ	0.9298
342	XXR	0.9298
343	GIF	0.9297
344	YCP	0.9297
345	NCA	0.9296
346	2MN	0.9295
347	BEZ	0.9294
348	KYD	0.9293
349	GLA	0.9292
350	LSA	0.9290
351	FEH	0.9288
352	WOO	0.9287
353	DFB	0.9287
354	8ZE	0.9285
355	MT0	0.9284
356	SWA	0.9283
357	FUL	0.9282
358	BEN	0.9282
359	23A	0.9281
360	MR1	0.9281
361	BMA	0.9281
362	KOJ	0.9280
363	2ZQ	0.9280
364	8EZ	0.9280
365	IPB	0.9279
366	F12	0.9278
367	7MU	0.9278
368	AL0	0.9277
369	NDM	0.9277
370	GIO	0.9277
371	NIO	0.9276
372	BCU	0.9275
373	UAN	0.9275
374	AZ9	0.9273
375	II6	0.9272
376	D1X	0.9272
377	S76	0.9272
378	4MU	0.9271
379	OMD	0.9269
380	34D	0.9268
381	PD2	0.9267
382	N2I	0.9266
383	DHK	0.9266
384	2DR	0.9266
385	VGD	0.9266
386	FBW	0.9266
387	SJ5	0.9265
388	0F9	0.9263
389	SYG	0.9262
390	ES7	0.9261
391	6GU	0.9260
392	M6N	0.9260
393	SXS	0.9259
394	0CU	0.9259
395	IPZ	0.9258
396	7W4	0.9257
397	DHQ	0.9256
398	NID	0.9256
399	PZA	0.9256
400	2XX	0.9255
401	NFQ	0.9253
402	OAA	0.9253
403	TAR	0.9252
404	2EC	0.9252
405	KJY	0.9250
406	GDE	0.9250
407	92K	0.9249
408	HQD	0.9249
409	NBZ	0.9248
410	FH2	0.9247
411	R8A	0.9247
412	FYU	0.9247
413	CN0	0.9246
414	JFJ	0.9242
415	D48	0.9242
416	NCD	0.9242
417	XCZ	0.9241
418	MWM	0.9241
419	BHO	0.9241
420	QWN	0.9240
421	SE2	0.9240
422	MLT	0.9240
423	4XR	0.9240
424	GBD	0.9239
425	HIO	0.9239
426	OXZ	0.9238
427	82I	0.9238
428	SYV	0.9238
429	MXN	0.9235
430	1AL	0.9234
431	RNT	0.9233
432	8NY	0.9232
433	ZWZ	0.9232
434	1P8	0.9232
435	TLA	0.9231
436	GCW	0.9231
437	ES2	0.9230
438	7N0	0.9228
439	SVD	0.9227
440	TH7	0.9227
441	QAT	0.9225
442	INE	0.9223
443	CTS	0.9222
444	2CQ	0.9222
445	RSF	0.9222
446	4ME	0.9221
447	FBB	0.9221
448	37T	0.9221
449	SS1	0.9221
450	MNN	0.9220
451	SKM	0.9219
452	GAG	0.9219
453	JZ1	0.9219
454	J5I	0.9218
455	7ME	0.9217
456	FDK	0.9217
457	2LP	0.9217
458	1DJ	0.9216
459	BAM	0.9216
460	DIE	0.9216
461	URC	0.9216
462	C2Y	0.9215
463	NIZ	0.9214
464	2LY	0.9213
465	JA8	0.9213
466	O7U	0.9213
467	BK9	0.9212
468	AGK	0.9212
469	RXA	0.9211
470	2YU	0.9210
471	HQ9	0.9210
472	3FH	0.9210
473	24B	0.9210
474	0R0	0.9209
475	3MG	0.9208
476	1LN	0.9208
477	GJS	0.9207
478	4AA	0.9207
479	1WG	0.9207
480	PYQ	0.9206
481	XYS	0.9206
482	1GN	0.9205
483	5RO	0.9205
484	ET2	0.9205
485	4ZE	0.9205
486	JUG	0.9204
487	CTL	0.9204
488	GM7	0.9203
489	RAM	0.9203
490	EQT	0.9203
491	G1O	0.9201
492	HX3	0.9200
493	X05	0.9199
494	UNU	0.9199
495	069	0.9197
496	DPZ	0.9197
497	FP1	0.9197
498	GZ8	0.9196
499	5JC	0.9196
500	45L	0.9195
501	QOS	0.9195
502	8G0	0.9194
503	RNS	0.9194
504	DEN	0.9193
505	SRT	0.9192
506	X6X	0.9192
507	HMU	0.9191
508	BEA	0.9191
509	5AC	0.9191
510	NDH	0.9190
511	7VJ	0.9190
512	HH5	0.9190
513	Z5P	0.9189
514	0N7	0.9188
515	BSX	0.9187
516	36R	0.9186
517	ZXD	0.9186
518	12M	0.9184
519	PBC	0.9184
520	B55	0.9184
521	QSC	0.9183
522	TM7	0.9183
523	GOX	0.9182
524	MZG	0.9182
525	QPR	0.9181
526	ABV	0.9180
527	2AK	0.9180
528	HMH	0.9180
529	92P	0.9179
530	LMR	0.9177
531	CLW	0.9177
532	URF	0.9177
533	XM0	0.9176
534	AZF	0.9175
535	QXW	0.9175
536	BR9	0.9175
537	K2T	0.9174
538	MAN	0.9173
539	QAS	0.9173
540	150	0.9173
541	091	0.9173
542	NTM	0.9171
543	AJV	0.9170
544	JND	0.9170
545	47J	0.9169
546	0LH	0.9169
547	LDP	0.9169
548	QSH	0.9169
549	2ZM	0.9168
550	A1U	0.9168
551	BTY	0.9167
552	2AC	0.9167
553	BE7	0.9166
554	LFR	0.9166
555	5JQ	0.9166
556	NQ	0.9165
557	BCP	0.9165
558	NTZ	0.9165
559	6VD	0.9165
560	XYD	0.9162
561	8TX	0.9162
562	261	0.9161
563	ISE	0.9161
564	2FY	0.9160
565	HLR	0.9160
566	3NY	0.9159
567	NTN	0.9158
568	UEG	0.9157
569	VOH	0.9157
570	HT4	0.9156
571	K5W	0.9156
572	XBZ	0.9155
573	J9Q	0.9154
574	23J	0.9154
575	VGL	0.9152
576	MWJ	0.9152
577	JZ9	0.9151
578	FDB	0.9150
579	GIV	0.9149
580	ODO	0.9149
581	IDM	0.9148
582	CFI	0.9148
583	AX7	0.9147
584	34A	0.9145
585	DYA	0.9145
586	RMN	0.9144
587	ISZ	0.9144
588	F9P	0.9143
589	H76	0.9143
590	IND	0.9143
591	AC0	0.9142
592	BZF	0.9142
593	0HO	0.9141
594	75K	0.9140
595	3DM	0.9140
596	G4D	0.9139
597	2MP	0.9139
598	UGC	0.9138
599	LRH	0.9138
600	5VM	0.9138
601	AH8	0.9137
602	GTR	0.9137
603	270	0.9137
604	TH0	0.9137
605	XAZ	0.9136
606	9PY	0.9133
607	ONR	0.9132
608	TSS	0.9132
609	OXQ	0.9132
610	27Y	0.9131
611	PA1	0.9127
612	TOF	0.9127
613	VK3	0.9126
614	BZI	0.9126
615	2PG	0.9125
616	XSP	0.9125
617	4HO	0.9125
618	PHT	0.9125
619	EKZ	0.9125
620	QDK	0.9123
621	4JJ	0.9123
622	149	0.9123
623	6NT	0.9123
624	F4Z	0.9123
625	M2H	0.9122
626	QX2	0.9122
627	4CL	0.9122
628	UFO	0.9122
629	X0V	0.9122
630	0JD	0.9122
631	3A9	0.9120
632	IFP	0.9120
633	WBU	0.9120
634	M1H	0.9120
635	O2A	0.9119
636	MS9	0.9118
637	4NG	0.9117
638	LNR	0.9117
639	YSO	0.9116
640	ROR	0.9115
641	FBM	0.9115
642	T6C	0.9115
643	JZ2	0.9114
644	4TU	0.9112
645	TSR	0.9111
646	QWW	0.9111
647	AFR	0.9111
648	HA7	0.9111
649	2A7	0.9109
650	F9Y	0.9109
651	43M	0.9109
652	DIG	0.9108
653	TEO	0.9108
654	7CZ	0.9107
655	H7Y	0.9106
656	B62	0.9106
657	PZI	0.9106
658	R9S	0.9105
659	KLW	0.9104
660	Y8I	0.9104
661	0FO	0.9104
662	SOE	0.9103
663	HY3	0.9103
664	JBQ	0.9102
665	URQ	0.9102
666	D07	0.9100
667	A29	0.9100
668	TDR	0.9100
669	284	0.9100
670	TTY	0.9098
671	MNM	0.9098
672	4FH	0.9098
673	2FG	0.9096
674	94B	0.9095
675	MBG	0.9094
676	5JL	0.9094
677	B53	0.9094
678	RSO	0.9094
679	GLF	0.9091
680	275	0.9091
681	LZ1	0.9091
682	L99	0.9090
683	2HU	0.9090
684	QBK	0.9090
685	4YO	0.9090
686	2MI	0.9089
687	ICP	0.9087
688	PYD	0.9087
689	NPO	0.9087
690	SS2	0.9087
691	0HN	0.9086
692	PXM	0.9085
693	JIF	0.9083
694	BNS	0.9083
695	SF9	0.9082
696	YIO	0.9082
697	GVH	0.9082
698	INS	0.9081
699	8OZ	0.9081
700	5UC	0.9081
701	0R1	0.9080
702	HNQ	0.9080
703	PCA	0.9079
704	FX1	0.9079
705	KDV	0.9079
706	97T	0.9079
707	OA3	0.9078
708	FBT	0.9078
709	TC7	0.9078
710	M58	0.9077
711	4SX	0.9077
712	0CT	0.9077
713	FCA	0.9076
714	6ME	0.9076
715	MZB	0.9076
716	5MH	0.9076
717	JXN	0.9076
718	ZZT	0.9076
719	DNC	0.9075
720	5CL	0.9075
721	R9Y	0.9074
722	DMJ	0.9074
723	PRZ	0.9074
724	MPI	0.9074
725	PRY	0.9073
726	TEP	0.9073
727	2TQ	0.9072
728	JZ4	0.9071
729	DQU	0.9071
730	MQN	0.9071
731	FGZ	0.9070
732	GAF	0.9069
733	2RH	0.9069
734	DA4	0.9068
735	7WR	0.9067
736	GV9	0.9067
737	RJY	0.9067
738	12B	0.9067
739	14J	0.9067
740	PAF	0.9066
741	1U6	0.9066
742	9FL	0.9065
743	A13	0.9064
744	1MC	0.9063
745	226	0.9061
746	RCO	0.9061
747	URA	0.9061
748	DGJ	0.9060
749	AEH	0.9059
750	TLD	0.9059
751	8IG	0.9058
752	45C	0.9057
753	4JP	0.9057
754	4JQ	0.9057
755	CRS	0.9057
756	7MH	0.9056
757	I1E	0.9056
758	8XQ	0.9056
759	FUC	0.9053
760	NVU	0.9053
761	FLV	0.9053
762	CFF	0.9053
763	3CH	0.9051
764	ASP	0.9051
765	CWJ	0.9050
766	FPK	0.9049
767	DTL	0.9048
768	HIS	0.9047
769	RD4	0.9046
770	4RW	0.9046
771	9KH	0.9046
772	8W9	0.9045
773	XIY	0.9041
774	MFB	0.9040
775	COI	0.9040
776	XHP	0.9040
777	948	0.9039
778	9RW	0.9039
779	PFB	0.9039
780	ABI	0.9037
781	DHS	0.9037
782	TRA	0.9037
783	NGO	0.9037
784	ADA	0.9037
785	ZZ3	0.9037
786	ARB	0.9035
787	2BG	0.9035
788	1F1	0.9034
789	0TU	0.9034
790	IF7	0.9032
791	RIP	0.9032
792	OTW	0.9031
793	P92	0.9031
794	LG3	0.9031
795	I2M	0.9030
796	XUL	0.9030
797	0TR	0.9029
798	PEY	0.9028
799	PHB	0.9028
800	44V	0.9027
801	GTZ	0.9027
802	3RK	0.9026
803	IT2	0.9026
804	LG5	0.9026
805	GOG	0.9024
806	4P0	0.9024
807	FA1	0.9023
808	28N	0.9023
809	CYT	0.9023
810	6R8	0.9022
811	94W	0.9022
812	I1N	0.9017
813	RPQ	0.9015
814	5NI	0.9014
815	DFU	0.9013
816	9R5	0.9013
817	CBF	0.9012
818	HY1	0.9011
819	F81	0.9009
820	SMN	0.9008
821	EOL	0.9007
822	BDF	0.9006
823	GOO	0.9006
824	TVP	0.9006
825	44W	0.9006
826	MT5	0.9005
827	35C	0.9005
828	463	0.9004
829	HA5	0.9004
830	KFH	0.9002
831	IPM	0.9002
832	Z82	0.9000
833	LYL	0.8999
834	VXX	0.8999
835	TFU	0.8998
836	39O	0.8998
837	26D	0.8997
838	D3M	0.8997
839	8H8	0.8996
840	CLZ	0.8994
841	GXL	0.8993
842	GT0	0.8992
843	PAB	0.8991
844	MRZ	0.8989
845	SF6	0.8989
846	CIT	0.8986
847	BVF	0.8986
848	M4E	0.8985
849	4XV	0.8985
850	AUD	0.8985
851	FPY	0.8984
852	B57	0.8983
853	AN0	0.8983
854	HQJ	0.8983
855	PBA	0.8981
856	AC6	0.8981
857	QIC	0.8981
858	PFL	0.8981
859	P3K	0.8979
860	3BU	0.8978
861	M0W	0.8976
862	MBD	0.8976
863	6NI	0.8975
864	0MK	0.8975
865	OHP	0.8975
866	6RQ	0.8975
867	TAG	0.8974
868	4AV	0.8973
869	9CA	0.8973
870	AMC	0.8972
871	4JO	0.8971
872	6JN	0.8971
873	SAF	0.8969
874	EDR	0.8968
875	FUF	0.8966
876	RBL	0.8964
877	5XB	0.8963
878	IDH	0.8963
879	MVN	0.8963
880	HBD	0.8963
881	PEZ	0.8963
882	SD4	0.8962
883	GXY	0.8959
884	3AL	0.8959
885	NEQ	0.8956
886	KIB	0.8955
887	8GF	0.8954
888	JAW	0.8953
889	N2Z	0.8951
890	AIN	0.8950
891	FUB	0.8950
892	FB2	0.8950
893	FUD	0.8949
894	JFD	0.8949
895	AS3	0.8949
896	HGQ	0.8948
897	7B3	0.8948
898	2A9	0.8945
899	FHN	0.8944
900	8HC	0.8944
901	KTA	0.8944
902	1AB	0.8943
903	PQ0	0.8943
904	B3R	0.8943
905	1M2	0.8942
906	5NE	0.8942
907	ZB1	0.8941
908	ZBT	0.8940
909	95Z	0.8940
910	0FK	0.8939
911	DEE	0.8938
912	IUR	0.8938
913	FCB	0.8938
914	XBT	0.8938
915	PMB	0.8937
916	EMZ	0.8936
917	8WO	0.8936
918	2FQ	0.8936
919	PHU	0.8934
920	PYG	0.8933
921	FAN	0.8932
922	JTH	0.8932
923	TPA	0.8932
924	4P5	0.8930
925	EJZ	0.8929
926	61M	0.8929
927	717	0.8929
928	HLD	0.8928
929	PBZ	0.8928
930	M3T	0.8928
931	826	0.8928
932	OTD	0.8927
933	1Y6	0.8927
934	3YP	0.8926
935	KP6	0.8925
936	H62	0.8924
937	4H2	0.8924
938	HEW	0.8924
939	HFB	0.8924
940	RM4	0.8922
941	EDG	0.8922
942	15N	0.8922
943	AHB	0.8921
944	NSP	0.8920
945	MSN	0.8920
946	EV0	0.8919
947	Q7A	0.8919
948	1IT	0.8918
949	7D2	0.8917
950	MB1	0.8916
951	ARA	0.8915
952	1X7	0.8912
953	N7P	0.8911
954	CIG	0.8911
955	SR1	0.8910
956	4XS	0.8910
957	GCO	0.8910
958	6UA	0.8909
959	4MA	0.8907
960	QX4	0.8907
961	PKU	0.8906
962	8EW	0.8906
963	PBE	0.8905
964	FQI	0.8903
965	TZE	0.8902
966	FBU	0.8902
967	ABE	0.8901
968	42J	0.8900
969	9KT	0.8899
970	MFU	0.8898
971	3FA	0.8898
972	GTL	0.8897
973	0GZ	0.8895
974	9FE	0.8895
975	8VN	0.8895
976	DQA	0.8895
977	ICT	0.8893
978	64K	0.8893
979	KPL	0.8893
980	MHK	0.8892
981	ICF	0.8892
982	GLY PRO	0.8891
983	13X	0.8891
984	PEP	0.8890
985	282	0.8890
986	CRN	0.8890
987	HKD	0.8889
988	1XX	0.8888
989	BR8	0.8888
990	30G	0.8888
991	PHH	0.8887
992	TBP	0.8887
993	MVL	0.8887
994	7MX	0.8887
995	TWO	0.8885
996	AMG	0.8884
997	5AN	0.8884
998	23W	0.8883
999	8GK	0.8883
1000	DQN	0.8882
1001	1DV	0.8882
1002	I6G	0.8881
1003	PEQ	0.8880
1004	JYB	0.8880
1005	2CM	0.8879
1006	PH2	0.8878
1007	7WG	0.8877
1008	KIA	0.8877
1009	MJ2	0.8876
1010	HTP	0.8876
1011	PRF	0.8875
1012	0FN	0.8874
1013	52C	0.8874
1014	DHR	0.8874
1015	GMN	0.8872
1016	3CE	0.8871
1017	PSV	0.8871
1018	HBA	0.8871
1019	QY9	0.8871
1020	AJY	0.8870
1021	XRG	0.8870
1022	GNL	0.8869
1023	2MY	0.8869
1024	209	0.8868
1025	TGX	0.8868
1026	JKZ	0.8868
1027	KDF	0.8867
1028	H33	0.8866
1029	3ZQ	0.8866
1030	DUB	0.8865
1031	BNT	0.8865
1032	N8P	0.8863
1033	Q02	0.8862
1034	PAC	0.8862
1035	4VY	0.8862
1036	174	0.8862
1037	AX2	0.8862
1038	1KP	0.8860
1039	SW7	0.8859
1040	C9E	0.8859
1041	51F	0.8859
1042	2C9	0.8859
1043	ZVO	0.8858
1044	3SL	0.8858
1045	HHR	0.8858
1046	FLM	0.8857
1047	LDR	0.8857
1048	HHQ	0.8856
1049	GCV	0.8854
1050	SYA	0.8853
1051	6MH	0.8853
1052	URP	0.8853
1053	RHU	0.8852
1054	FA3	0.8851
1055	15E	0.8849
1056	L5V	0.8846
1057	X8D	0.8846
1058	JB8	0.8845
1059	SYN	0.8845
1060	JDN	0.8845
1061	NK2	0.8845
1062	PCI	0.8845
1063	FBG	0.8844
1064	5ZE	0.8843
1065	APG	0.8842
1066	HBX	0.8842
1067	P72	0.8841
1068	UFV	0.8841
1069	QUS	0.8840
1070	M4T	0.8840
1071	ZYR	0.8840
1072	K3Q	0.8839
1073	GIM	0.8838
1074	2ZX	0.8836
1075	6OT	0.8836
1076	3MC	0.8835
1077	PY7	0.8835
1078	ZZ8	0.8834
1079	IBF	0.8834
1080	ABN	0.8833
1081	E1T	0.8833
1082	2AS	0.8833
1083	FPI	0.8833
1084	CKU	0.8831
1085	40O	0.8830
1086	6BL	0.8829
1087	9ZE	0.8827
1088	3AY	0.8826
1089	HSE	0.8825
1090	40E	0.8825
1091	SIF	0.8824
1092	LI6	0.8824
1093	1U1	0.8823
1094	BCF	0.8821
1095	4VP	0.8819
1096	ERH	0.8816
1097	1QP	0.8815
1098	JF2	0.8815
1099	BBF	0.8815
1100	K17	0.8815
1101	APY	0.8814
1102	HDH	0.8811
1103	IAC	0.8811
1104	9TY	0.8810
1105	JXW	0.8810
1106	2F6	0.8809
1107	3R9	0.8808
1108	YTB	0.8807
1109	ENL	0.8807
1110