Receptor
PDB id Resolution Class Description Source Keywords
5FJX 2.45 Å NON-ENZYME: OTHER YEAST DELTA-COP-I MU-HOMOLOGY DOMAIN COMPLEXED WITH GCS1 WXXF PEPTIDE SACCHAROMYCES CEREVISIAE PROTEIN TRANSPORT COP-I VESICLE COAT PROTEIN
Ref.: STRUCTURAL BASIS FOR THE BINDING OF TRYPTOPHAN-BASE BY DELTA-COP. PROC.NATL.ACAD.SCI.USA V. 112 14242 2015
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ASP GLU ASP LYS TRP ASP ASP PHE E:4;
D:3;
Valid;
Valid;
Atoms found LESS than expected: % Diff = 0;
Atoms found LESS than expected: % Diff = 0;
Kd = 11 uM
822.829 n/a O=C([...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
5FJZ 1.9 Å NON-ENZYME: OTHER YEAST DELTA-COP-I MU-HOMOLOGY DOMAIN COMPLEXED WITH DSL1 WXWXV PEPTIDE SACCHAROMYCES CEREVISIAE PROTEIN TRANSPORT COP-I VESICLE COAT PROTEIN
Ref.: STRUCTURAL BASIS FOR THE BINDING OF TRYPTOPHAN-BASE BY DELTA-COP. PROC.NATL.ACAD.SCI.USA V. 112 14242 2015
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1579 families.
1 5FJZ Kd = 10 uM ASP ASP TRP ASN TRP GLU VAL GLU ASP n/a n/a
2 5FJX Kd = 11 uM ASP GLU ASP LYS TRP ASP ASP PHE n/a n/a
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1312 families.
1 5FJZ Kd = 10 uM ASP ASP TRP ASN TRP GLU VAL GLU ASP n/a n/a
2 5FJX Kd = 11 uM ASP GLU ASP LYS TRP ASP ASP PHE n/a n/a
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1130 families.
1 5FJZ Kd = 10 uM ASP ASP TRP ASN TRP GLU VAL GLU ASP n/a n/a
2 5FJX Kd = 11 uM ASP GLU ASP LYS TRP ASP ASP PHE n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ASP GLU ASP LYS TRP ASP ASP PHE; Similar ligands found: 86
No: Ligand ECFP6 Tc MDL keys Tc
1 ASP GLU ASP LYS TRP ASP ASP PHE 1 1
2 ASP SER TRP LYS ASP GLY CYS TYR 0.669291 0.847458
3 ILE ASP TRP PHE ASP GLY LYS ASP 0.666667 0.909091
4 ALA LEU ASP LYS TRP ASP 0.657658 0.907407
5 ILE ASP TRP PHE ASP GLY LYS GLU 0.640625 0.909091
6 ILE ASP TRP PHE GLU GLY LYS GLU 0.627907 0.875
7 GLU GLN ASP LYS TRP ALA SER 0.6 0.890909
8 ALA LEU ASP LYS TRP ALA SER 0.595041 0.859649
9 LYS TRP LYS 0.592233 0.901961
10 GLU ALA ASP LYS TRP GLN SER 0.592 0.890909
11 GLU LEU ASP LYS TRP ALA SER 0.592 0.859649
12 GLU ASN ASP LYS TRP ALA SER 0.592 0.875
13 GLU LEU ASP LYS TRP ALA ASN 0.587302 0.875
14 LEU LEU GLU LEU ASP LYS TRP ALA NH2 0.585366 0.888889
15 GLU LEU ASP LYS TRP ALA GLY 0.580645 0.872727
16 ASP TRP ASN 0.578431 0.826923
17 GLU ASP ASN ASP TRP ASN 0.578431 0.826923
18 LEU GLU LEU ASP LYS TRP ALA SER LEU 0.568182 0.844828
19 GLU LEU ASP ORN TRP ALA SER 0.559055 0.842105
20 ASP ASN ARG LEU GLY LEU VAL TYR TRP PHE 0.557522 0.719298
21 GLU GLU TYR LEU LYS ALA TRP THR PHE 0.555556 0.803279
22 LYS TRP 0.544554 0.9
23 SER TRP PHE GLN THR ASP LEU 0.533835 0.79661
24 SER VAL TYR ASP PHE PHE VAL TRP LEU 0.530303 0.754098
25 ACE ASN PRO ASP TRP ASP PHE ASN NH2 0.528 0.925926
26 ACE ASN TRP GLU THR PHE 0.528 0.775862
27 ALA LEU ASP LYS TRP GLN ASN 0.525 0.888889
28 ASN ASP LYS TYR GLU PRO PHE TRP GLU 0.522293 0.78125
29 ASP ASP TRP ASN TRP GLU VAL GLU ASP 0.520661 0.803571
30 GLU LEU GLU LYS TRP ALA SER 0.51938 0.810345
31 GLN ALA SER GLN ASP VAL LYS ASN TRP 0.517986 0.830508
32 PCA LYS TRP 0.513043 0.886792
33 GLU ASN GLN LYS GLU TYR PHE PHE 0.512605 0.754386
34 SER ARG ARG TRP ARG ARG TRP ASN ARG 0.512195 0.790323
35 ASN GLN LEU ALA TRP PHE ASP THR ASP LEU 0.510638 0.775862
36 ASP TRP GLU ILE VAL 0.504132 0.781818
37 ACE GLU TRP TRP TRP 0.5 0.792453
38 ARG ARG LYS TRP ARG ARG TRP HIS LEU 0.492647 0.774194
39 TYR GLU TRP 0.491228 0.796296
40 TRP ASN TRP PHE ASP ILE THR ASN LYS 0.489209 0.733333
41 GLU LEU ASP HOX TRP ALA SER 0.488889 0.79661
42 ARG PHE MET ASP TYR TRP GLU GLY LEU 0.487013 0.695652
43 MET ASN TRP ASN ILE 0.486957 0.767857
44 VAL ASP SER LYS ASN THR SER SER TRP 0.481752 0.830508
45 ARG ARG LYS TRP CIR ARG TRP HIS LEU 0.478571 0.761905
46 SER TRP PHE PRO 0.475806 0.774194
47 GLN ALA SER GLN GLU VAL LYS ASN TRP 0.475524 0.830508
48 GLY SER ASP PRO TRP LYS 0.474074 0.790323
49 GLU LEU ASP NRG TRP ALA SER 0.472222 0.657534
50 ASP PHE 0.468085 0.66
51 TYR TYR GLU SER ASP TRP LEU 0.459854 0.754098
52 ASP PHE GLU ASP TYR GLU PHE ASP 0.457627 0.701754
53 PHE GLN TRP MET GLY TYR GLU LEU TRP 0.456954 0.734375
54 ALA LEU ASP LEU PHE 0.456311 0.611111
55 PRO GLY LEU TRP LYS SER 0.455882 0.839286
56 ASN ASP TRP LEU LEU PRO SER TYR 0.454545 0.714286
57 LYS ARG TRP ILE ILE LEU GLY LEU ASN LYS 0.454545 0.738462
58 MET ASP TRP ASN MET HIS ALA ALA 0.453901 0.754098
59 GLU LEU ASP HIS TRP ALA SER 0.453237 0.766667
60 LYS GLN TRP ASP ASN TYR GLU PHE ILE TRP 0.452703 0.737705
61 LYS VAL PRO ARG ASN GLN ASP TRP LEU 0.445122 0.7
62 TRP GLU GLU LEU 0.443478 0.796296
63 TYR GLU LEU ASP GLU LYS PHE ASP ARG LEU 0.439716 0.676923
64 LYS ARG TRP ILE ILE MET GLY LEU ASN LYS 0.438272 0.695652
65 GLY LEU MET TRP LEU SER TYR PHE VAL 0.434483 0.712121
66 ARG ARG ARG TRP HIS ARG TRP ARG LEU 0.433824 0.758065
67 ARG LEU TRP SER 0.433071 0.714286
68 THR ASN GLU PHE TYR PHE 0.431034 0.678571
69 GLU TYR GLY PRO LYS TRP ASN LYS 0.427632 0.75
70 ALA ASN SER ARG TRP GLN ASP THR ARG LEU 0.427632 0.716418
71 LYS MET ASP SEP PHE LEU ASP MET GLN LEU 0.427586 0.608696
72 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.427536 0.723077
73 TRP LEU PHE VAL GLN ARG ASP SER LYS GLU 0.42735 0.722222
74 ALA SER ASN GLU ASN TRP GLU THR MET 0.42446 0.746032
75 MET LEU ILE TYR SER MET TRP GLY LYS 0.42236 0.720588
76 ALA LYS PHE ARG HIS ASP 0.41791 0.79661
77 GLN PHE LYS ASP ASN VAL ILE LEU LEU 0.415493 0.736842
78 GLU ILE ILE ASN PHE GLU LYS LEU 0.411765 0.689655
79 GLU GLY PRO ARG ASN GLN ASP TRP LEU 0.408537 0.7
80 LYS ARG LYS SER ARG TRP ASP GLU THR PRO 0.407643 0.690141
81 ILE ARG TYR PRO LYS THR PHE GLY TRP 0.40678 0.662162
82 ASP PHE GLU GLU ILE 0.405172 0.666667
83 GLU THR LEU GLU ASP SER VAL PHE 0.401786 0.631579
84 ARG GLN PHE GLY PRO ASP TRP ILE VAL ALA 0.40113 0.710145
85 GLU GLN TYR LYS PHE TYR SER VAL 0.4 0.704918
86 GLY LYS ILE SER LYS HIS TRP THR GLY ILE 0.4 0.777778
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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