Receptor
PDB id Resolution Class Description Source Keywords
6FLD 2.4 Å EC: 3.1.1.7 CARBAMYLATED T. CALIFORNICA ACETYLCHOLINETERASE BOUND TO UNC HYBRID REACTIVATOR 1 TETRONARCE CALIFORNICA ACETYLCHOLINESTERASE HYBRID REACTIVATORS ORGANOPHOSPHATE INHSTRUCTURE-BASED OPTIMIZATION HYDROLASE
Ref.: STRUCTURE-BASED OPTIMIZATION OF NONQUATERNARY REACT OF ACETYLCHOLINESTERASE INHIBITED BY ORGANOPHOSPHOR AGENTS. J. MED. CHEM. V. 61 7630 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO A:612;
A:611;
A:613;
Invalid;
Invalid;
Invalid;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
NAG A:603;
A:601;
A:602;
Valid;
Valid;
Valid;
none;
none;
none;
submit data
221.208 C8 H15 N O6 CC(=O...
CL A:608;
A:606;
A:607;
A:610;
A:609;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
submit data
35.453 Cl [Cl-]
1PG A:605;
Invalid;
none;
submit data
252.305 C11 H24 O6 COCCO...
DQ5 A:604;
Valid;
none;
submit data
390.478 C23 H26 N4 O2 c1ccc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2CKM 2.15 Å EC: 3.1.1.7 TORPEDO CALIFORNICA ACETYLCHOLINESTERASE COMPLEXED WITH ALKY LINKED BIS-TACRINE DIMER (7 CARBON LINKER) TORPEDO CALIFORNICA SERINE ESTERASE SERINE HYDROLASE ALZHEIMER-prime S DISEASE NERVMUSCLE SYNAPSE MEMBRANE HYDROLASE GPI-ANCHOR LIPOPROTEGLYCOPROTEIN CHOLINESTERASE ALTERNATIVE SPLICING NEUROTRDEGRADATION
Ref.: COMPLEXES OF ALKYLENE-LINKED TACRINE DIMERS WITH TO CALIFORNICA ACETYLCHOLINESTERASE: BINDING OF BIS5-T PRODUCES A DRAMATIC REARRANGEMENT IN THE ACTIVE-SIT J. MED. CHEM. V. 49 5491 2006
Members (49)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 1ODC - A8B C30 H36 N4 c1ccc2c(c1....
2 1UT6 - A8N C21 H33 N3 c1ccc2c(c1....
3 6H14 - FW8 C35 H35 N9 O2 c1ccc2c(c1....
4 1EVE ic50 = 5.7 nM E20 C24 H29 N O3 COc1cc2c(c....
5 1H23 Ki = 4.5 nM E12 C30 H46 N4 O2 C1C[C@@H](....
6 1QTI - GNT C17 H21 N O3 C[N@@]1CC[....
7 2C4H - AT3 C7 H16 N O S CC(=O)SCC[....
8 2CEK - N8T C34 H41 N3 S c1ccc2c(c1....
9 2CMF - F11 C31 H36 N4 c1ccc2c(c1....
10 6EZG - C6K C24 H27 Cl N2 O2 COc1c2cc[n....
11 2V97 Ki ~ 20 nM CFQ C13 H19 As F3 N O3 C[As+](C)(....
12 1VOT Ki = 250 nM HUP C15 H18 N2 O C/C=C/1[C@....
13 1GPK Ki = 4.3 uM HUP C15 H18 N2 O C/C=C/1[C@....
14 6H12 - FJK C37 H41 N9 O3 c1cc2c(c(c....
15 2WG1 - FP1 C7 H10 N2 O CN1C=CC=C/....
16 4TVK - TJH C25 H22 Cl N3 O3 c1cc2c(c(c....
17 2VJB - CCD C8 H20 N O C[C@H](CCC....
18 3I6Z - G6X C29 H34 N2 O6 S COc1ccc2c3....
19 2ACK - EDR C10 H16 N O CC[N+](C)(....
20 2XI4 - AFT C17 H12 O6 COc1cc2c(c....
21 5E4T Ki = 40 nM MBT C16 H18 N3 S CN(C)c1ccc....
22 2C58 - ETM C5 H14 N S C[N+](C)(C....
23 2VJC - CHH C8 H18 N O CC(=O)CCC[....
24 6G1W - E0Z C27 H25 Cl N6 O3 COc1cc(ccc....
25 5NAP Ki = 11.12 nM DZ7 C24 H27 N O3 COc1cc2c(c....
26 1H22 Ki = 0.8 nM E10 C28 H42 N4 O2 C1C[C@@H](....
27 5BWC Ki = 0.061 uM HBP C19 H26 N4 O2 c1cc[n+](c....
28 1GQR - SAF C10 H15 N O C[C@@H](c1....
29 1DX6 ic50 = 652 nM GNT C17 H21 N O3 C[N@@]1CC[....
30 2VJD - CCD C8 H20 N O C[C@H](CCC....
31 2V96 Ki = 29 uM CFQ C13 H19 As F3 N O3 C[As+](C)(....
32 5NAU Ki = 29.86 nM DZ0 C23 H25 N O2 COc1ccc2c(....
33 2VJA - CCD C8 H20 N O C[C@H](CCC....
34 1GPN Ki = 0.334 uM HUB C16 H20 N2 O CC1=C[C@H]....
35 6G1U - E1K C14 H16 Cl N2 C[n+]1c2cc....
36 1JJB - PE7 C14 H30 O7 S C(COCCOCCO....
37 6FQN - E2W C23 H27 Cl N4 O2 c1cc2c(cc1....
38 1E66 Ki = 0.13 nM HUX C18 H19 Cl N2 CCC1=C[C@@....
39 1ZGC ic50 = 38.8 nM A2E C32 H44 N4 O c1ccc2c(c1....
40 3I6M - G3X C24 H34 N2 O3 COc1ccc2c3....
41 6FLD - NAG C8 H15 N O6 CC(=O)N[C@....
42 6G1V - E1N C19 H22 Cl N2 CCC1=C[C@@....
43 1ZGB ic50 = 8.8 nM A1E C32 H44 N4 O c1ccc2c(c1....
44 1W4L ic50 = 4 nM GL8 C32 H37 N2 O5 COc1ccc2c3....
45 2C5G - ETM C5 H14 N S C[N+](C)(C....
46 3ZV7 - NHG C11 H14 N2 O C[C@@]12CC....
47 2CKM Kd = 77 fM AA7 C33 H40 N4 c1ccc2c(c1....
48 1W76 ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
49 1W6R ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
70% Homology Family (118)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6QAD ic50 = 14 nM HUZ C25 H40 N4 O CCCCN[C@@H....
2 4B0O Ki = 7.3 uM 15F C15 H14 Cl3 N2 O [H]/N=C(/C....
3 6XTA ic50 = 2.8 nM O0Z C30 H42 N4 O CCCCN[C@@H....
4 4B0P Ki = 44 uM MF5 C14 H10 F5 N2 O C[n+]1cccc....
5 6SAM ic50 = 0.0645 uM L3H C21 H25 N2 O2 c1ccc(cc1)....
6 6QAB ic50 = 6.2 nM HUQ C26 H42 N3 O CCCC[N+](C....
7 5NN0 Kd = 11.1 pM 92H C30 H37 N3 O CN(C)CCN(C....
8 6QAE ic50 = 3 nM HUK C26 H45 N3 CCCC[NH+](....
9 6I0B ic50 = 9.1 nM 9A5 C30 H36 Cl N5 O c1ccc2c(c1....
10 6EQQ - H19 C18 H21 Cl N3 c1cc2c(cc1....
11 6R6W Ki = 18 nM JUB C35 H42 N7 O5 S c1ccc(cc1)....
12 6EQP Kd = 1.1 uM BUW C19 H24 N2 S CCN(CC)[C@....
13 5DYW ic50 = 4.9 nM 5HF C26 H32 N2 O3 S COCCN(C[C@....
14 1P0P - BCH C9 H20 N O S CCCC(=O)SC....
15 6R6V Ki = 88 nM JU5 C38 H45 N5 O3 S CCN(CC)c1c....
16 1P0M - CHT C5 H14 N O C[N+](C)(C....
17 6EP4 Ki = 4.5 uM DME C16 H38 N2 C[N+](C)(C....
18 4AQD - GLY C2 H5 N O2 C(C(=O)O)N
19 4BDS Ki = 25 nM THA C13 H14 N2 c1ccc2c(c1....
20 6QAA ic50 = 22 nM HUN C24 H38 N3 O CCCC[NH2+]....
21 1Q84 Ki = 8900 fM TZ4 C42 H45 N8 c1ccc(cc1)....
22 4ARB Kd = 1.3 uM C57 C17 H26 N4 O4 CCN1CCC[C@....
23 4ARA Kd = 0.9 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
24 4B80 ic50 = 40 uM A36 C13 H21 F N2 O2 S CCN(CC)CCN....
25 1N5R Ki = 2.2 uM PRM C27 H34 N4 CC[N+](C)(....
26 5EHZ Ki = 2.3 pM 5NZ C41 H43 N8 c1ccc(cc1)....
27 2HA6 - SCK C14 H30 N2 O4 C[N+](C)(C....
28 2JF0 - HBP C19 H26 N4 O2 c1cc[n+](c....
29 4B82 ic50 = 41 uM B3Z C12 H19 F N2 O2 S CCN(CC)CCN....
30 2GYU - HI6 C14 H16 N4 O3 c1cc[n+](c....
31 4B7Z ic50 = 49 uM Q4Q C14 H24 N2 O2 S CCN(CC)CCN....
32 2WHQ - HI6 C14 H16 N4 O3 c1cc[n+](c....
33 1J07 Ki = 0.021 uM DCU C32 H44 N4 C[N+](C)(C....
34 1N5M - GMN C30 H60 N3 O3 CC[N+](CC)....
35 3ZLV - HI6 C14 H16 N4 O3 c1cc[n+](c....
36 5FOQ - GC8 C20 H22 Cl2 N2 O2 c1cc(ccc1C....
37 2GYW - OBI C14 H16 N4 O3 c1c[n+](cc....
38 5FUM - SOF C25 H33 N3 O2 CCN1CCN(CC....
39 2HA0 Kd = 0.037 mM CHH C8 H18 N O CC(=O)CCC[....
40 5EIE Ki = 23000 pM TZ2 C15 H17 N5 c1ccc2c(c1....
41 4BTL ic50 = 2.5 uM 5GZ C18 H22 Cl N3 O5 S CCN(CC)CCN....
42 4B85 ic50 = 88 uM B3W C12 H19 Cl N2 O2 S CCN(CC)CCN....
43 5FPP Kd = 100 uM HI6 C14 H16 N4 O3 c1cc[n+](c....
44 2HA5 - AT3 C7 H16 N O S CC(=O)SCC[....
45 2GYV - HBP C19 H26 N4 O2 c1cc[n+](c....
46 5OV9 ic50 = 2.2 uM CVI C25 H30 N3 CN(C)c1ccc....
47 2HA2 Kd = 0.022 mM SCK C14 H30 N2 O4 C[N+](C)(C....
48 4B83 - B3V C13 H22 N2 O3 S CCN(CC)CCN....
49 4A23 ic50 = 1.3 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
50 2HA3 Kd = 0.93 mM CHT C5 H14 N O C[N+](C)(C....
51 2WU4 - HBP C19 H26 N4 O2 c1cc[n+](c....
52 1ODC - A8B C30 H36 N4 c1ccc2c(c1....
53 1UT6 - A8N C21 H33 N3 c1ccc2c(c1....
54 6H14 - FW8 C35 H35 N9 O2 c1ccc2c(c1....
55 1EVE ic50 = 5.7 nM E20 C24 H29 N O3 COc1cc2c(c....
56 1H23 Ki = 4.5 nM E12 C30 H46 N4 O2 C1C[C@@H](....
57 1QTI - GNT C17 H21 N O3 C[N@@]1CC[....
58 2C4H - AT3 C7 H16 N O S CC(=O)SCC[....
59 2CEK - N8T C34 H41 N3 S c1ccc2c(c1....
60 2CMF - F11 C31 H36 N4 c1ccc2c(c1....
61 6EZG - C6K C24 H27 Cl N2 O2 COc1c2cc[n....
62 2V97 Ki ~ 20 nM CFQ C13 H19 As F3 N O3 C[As+](C)(....
63 1VOT Ki = 250 nM HUP C15 H18 N2 O C/C=C/1[C@....
64 1GPK Ki = 4.3 uM HUP C15 H18 N2 O C/C=C/1[C@....
65 6H12 - FJK C37 H41 N9 O3 c1cc2c(c(c....
66 2WG1 - FP1 C7 H10 N2 O CN1C=CC=C/....
67 4TVK - TJH C25 H22 Cl N3 O3 c1cc2c(c(c....
68 2VJB - CCD C8 H20 N O C[C@H](CCC....
69 3I6Z - G6X C29 H34 N2 O6 S COc1ccc2c3....
70 2ACK - EDR C10 H16 N O CC[N+](C)(....
71 2XI4 - AFT C17 H12 O6 COc1cc2c(c....
72 5E4T Ki = 40 nM MBT C16 H18 N3 S CN(C)c1ccc....
73 2C58 - ETM C5 H14 N S C[N+](C)(C....
74 2VJC - CHH C8 H18 N O CC(=O)CCC[....
75 6G1W - E0Z C27 H25 Cl N6 O3 COc1cc(ccc....
76 5NAP Ki = 11.12 nM DZ7 C24 H27 N O3 COc1cc2c(c....
77 1H22 Ki = 0.8 nM E10 C28 H42 N4 O2 C1C[C@@H](....
78 5BWC Ki = 0.061 uM HBP C19 H26 N4 O2 c1cc[n+](c....
79 1GQR - SAF C10 H15 N O C[C@@H](c1....
80 1DX6 ic50 = 652 nM GNT C17 H21 N O3 C[N@@]1CC[....
81 2VJD - CCD C8 H20 N O C[C@H](CCC....
82 2V96 Ki = 29 uM CFQ C13 H19 As F3 N O3 C[As+](C)(....
83 5NAU Ki = 29.86 nM DZ0 C23 H25 N O2 COc1ccc2c(....
84 2VJA - CCD C8 H20 N O C[C@H](CCC....
85 1GPN Ki = 0.334 uM HUB C16 H20 N2 O CC1=C[C@H]....
86 6G1U - E1K C14 H16 Cl N2 C[n+]1c2cc....
87 1JJB - PE7 C14 H30 O7 S C(COCCOCCO....
88 6FQN - E2W C23 H27 Cl N4 O2 c1cc2c(cc1....
89 1E66 Ki = 0.13 nM HUX C18 H19 Cl N2 CCC1=C[C@@....
90 1ZGC ic50 = 38.8 nM A2E C32 H44 N4 O c1ccc2c(c1....
91 3I6M - G3X C24 H34 N2 O3 COc1ccc2c3....
92 6FLD - NAG C8 H15 N O6 CC(=O)N[C@....
93 6G1V - E1N C19 H22 Cl N2 CCC1=C[C@@....
94 1ZGB ic50 = 8.8 nM A1E C32 H44 N4 O c1ccc2c(c1....
95 1W4L ic50 = 4 nM GL8 C32 H37 N2 O5 COc1ccc2c3....
96 2C5G - ETM C5 H14 N S C[N+](C)(C....
97 3ZV7 - NHG C11 H14 N2 O C[C@@]12CC....
98 2CKM Kd = 77 fM AA7 C33 H40 N4 c1ccc2c(c1....
99 1W76 ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
100 1W6R ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
101 4EY5 - HUP C15 H18 N2 O C/C=C/1[C@....
102 6O4X - AA C13 H11 N2 c1ccc2c(c1....
103 4EY7 - E20 C24 H29 N O3 COc1cc2c(c....
104 4M0E Ki = 0.7 uM 1YL C18 H14 O3 Cc1cccc2c1....
105 6O66 - LND C13 H16 N5 O2 c1c[n+](cc....
106 6O50 - EBW C27 H38 N2 O C[N+](C)(C....
107 5HF9 - HI6 C14 H16 N4 O3 c1cc[n+](c....
108 6U34 Ki = 157 uM PQV C10 H19 N3 O2 C1CCCN(CC1....
109 5HFA - FP1 C7 H10 N2 O CN1C=CC=C/....
110 6O5V - LND C13 H16 N5 O2 c1c[n+](cc....
111 4EY6 - GNT C17 H21 N O3 C[N@@]1CC[....
112 6CQY - VX C3 H9 O3 P CCO[P@](=O....
113 6NEA - HLO C15 H17 N5 O4 c1c[n+](cc....
114 4M0F Ki = 1.7 nM 1YK C29 H34 O9 C[C@@]12CC....
115 6CQW Kd = 0.000000064 M HI6 C14 H16 N4 O3 c1cc[n+](c....
116 6O4W - E20 C24 H29 N O3 COc1cc2c(c....
117 6CQU - HI6 C14 H16 N4 O3 c1cc[n+](c....
118 6U37 - PQV C10 H19 N3 O2 C1CCCN(CC1....
50% Homology Family (124)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1 families.
1 6QAD ic50 = 14 nM HUZ C25 H40 N4 O CCCCN[C@@H....
2 4B0O Ki = 7.3 uM 15F C15 H14 Cl3 N2 O [H]/N=C(/C....
3 6XTA ic50 = 2.8 nM O0Z C30 H42 N4 O CCCCN[C@@H....
4 4B0P Ki = 44 uM MF5 C14 H10 F5 N2 O C[n+]1cccc....
5 6SAM ic50 = 0.0645 uM L3H C21 H25 N2 O2 c1ccc(cc1)....
6 6QAB ic50 = 6.2 nM HUQ C26 H42 N3 O CCCC[N+](C....
7 5NN0 Kd = 11.1 pM 92H C30 H37 N3 O CN(C)CCN(C....
8 6QAE ic50 = 3 nM HUK C26 H45 N3 CCCC[NH+](....
9 6I0B ic50 = 9.1 nM 9A5 C30 H36 Cl N5 O c1ccc2c(c1....
10 6EQQ - H19 C18 H21 Cl N3 c1cc2c(cc1....
11 6R6W Ki = 18 nM JUB C35 H42 N7 O5 S c1ccc(cc1)....
12 6EQP Kd = 1.1 uM BUW C19 H24 N2 S CCN(CC)[C@....
13 5DYW ic50 = 4.9 nM 5HF C26 H32 N2 O3 S COCCN(C[C@....
14 1P0P - BCH C9 H20 N O S CCCC(=O)SC....
15 6R6V Ki = 88 nM JU5 C38 H45 N5 O3 S CCN(CC)c1c....
16 1P0M - CHT C5 H14 N O C[N+](C)(C....
17 6EP4 Ki = 4.5 uM DME C16 H38 N2 C[N+](C)(C....
18 4AQD - GLY C2 H5 N O2 C(C(=O)O)N
19 4BDS Ki = 25 nM THA C13 H14 N2 c1ccc2c(c1....
20 6QAA ic50 = 22 nM HUN C24 H38 N3 O CCCC[NH2+]....
21 5EHQ Ki = 33 pM 5O2 C41 H43 N8 c1ccc(cc1)....
22 1Q84 Ki = 8900 fM TZ4 C42 H45 N8 c1ccc(cc1)....
23 4ARB Kd = 1.3 uM C57 C17 H26 N4 O4 CCN1CCC[C@....
24 4ARA Kd = 0.9 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
25 4B80 ic50 = 40 uM A36 C13 H21 F N2 O2 S CCN(CC)CCN....
26 1N5R Ki = 2.2 uM PRM C27 H34 N4 CC[N+](C)(....
27 5EHZ Ki = 2.3 pM 5NZ C41 H43 N8 c1ccc(cc1)....
28 2HA6 - SCK C14 H30 N2 O4 C[N+](C)(C....
29 2JF0 - HBP C19 H26 N4 O2 c1cc[n+](c....
30 4B82 ic50 = 41 uM B3Z C12 H19 F N2 O2 S CCN(CC)CCN....
31 2GYU - HI6 C14 H16 N4 O3 c1cc[n+](c....
32 4B7Z ic50 = 49 uM Q4Q C14 H24 N2 O2 S CCN(CC)CCN....
33 2WHQ - HI6 C14 H16 N4 O3 c1cc[n+](c....
34 1J07 Ki = 0.021 uM DCU C32 H44 N4 C[N+](C)(C....
35 1N5M - GMN C30 H60 N3 O3 CC[N+](CC)....
36 3ZLV - HI6 C14 H16 N4 O3 c1cc[n+](c....
37 5FOQ - GC8 C20 H22 Cl2 N2 O2 c1cc(ccc1C....
38 2GYW - OBI C14 H16 N4 O3 c1c[n+](cc....
39 5FUM - SOF C25 H33 N3 O2 CCN1CCN(CC....
40 2HA0 Kd = 0.037 mM CHH C8 H18 N O CC(=O)CCC[....
41 5EIE Ki = 23000 pM TZ2 C15 H17 N5 c1ccc2c(c1....
42 4BTL ic50 = 2.5 uM 5GZ C18 H22 Cl N3 O5 S CCN(CC)CCN....
43 4B85 ic50 = 88 uM B3W C12 H19 Cl N2 O2 S CCN(CC)CCN....
44 5FPP Kd = 100 uM HI6 C14 H16 N4 O3 c1cc[n+](c....
45 2HA5 - AT3 C7 H16 N O S CC(=O)SCC[....
46 2GYV - HBP C19 H26 N4 O2 c1cc[n+](c....
47 5OV9 ic50 = 2.2 uM CVI C25 H30 N3 CN(C)c1ccc....
48 2HA2 Kd = 0.022 mM SCK C14 H30 N2 O4 C[N+](C)(C....
49 4B83 - B3V C13 H22 N2 O3 S CCN(CC)CCN....
50 4A23 ic50 = 1.3 uM C56 C17 H26 N4 O4 CCN1CCC[C@....
51 2HA3 Kd = 0.93 mM CHT C5 H14 N O C[N+](C)(C....
52 2WU4 - HBP C19 H26 N4 O2 c1cc[n+](c....
53 1ODC - A8B C30 H36 N4 c1ccc2c(c1....
54 1UT6 - A8N C21 H33 N3 c1ccc2c(c1....
55 6H14 - FW8 C35 H35 N9 O2 c1ccc2c(c1....
56 1EVE ic50 = 5.7 nM E20 C24 H29 N O3 COc1cc2c(c....
57 1H23 Ki = 4.5 nM E12 C30 H46 N4 O2 C1C[C@@H](....
58 1QTI - GNT C17 H21 N O3 C[N@@]1CC[....
59 2C4H - AT3 C7 H16 N O S CC(=O)SCC[....
60 2CEK - N8T C34 H41 N3 S c1ccc2c(c1....
61 2CMF - F11 C31 H36 N4 c1ccc2c(c1....
62 6EZG - C6K C24 H27 Cl N2 O2 COc1c2cc[n....
63 2V97 Ki ~ 20 nM CFQ C13 H19 As F3 N O3 C[As+](C)(....
64 1VOT Ki = 250 nM HUP C15 H18 N2 O C/C=C/1[C@....
65 1GPK Ki = 4.3 uM HUP C15 H18 N2 O C/C=C/1[C@....
66 6H12 - FJK C37 H41 N9 O3 c1cc2c(c(c....
67 2WG1 - FP1 C7 H10 N2 O CN1C=CC=C/....
68 4TVK - TJH C25 H22 Cl N3 O3 c1cc2c(c(c....
69 2VJB - CCD C8 H20 N O C[C@H](CCC....
70 3I6Z - G6X C29 H34 N2 O6 S COc1ccc2c3....
71 2ACK - EDR C10 H16 N O CC[N+](C)(....
72 2XI4 - AFT C17 H12 O6 COc1cc2c(c....
73 5E4T Ki = 40 nM MBT C16 H18 N3 S CN(C)c1ccc....
74 2C58 - ETM C5 H14 N S C[N+](C)(C....
75 2VJC - CHH C8 H18 N O CC(=O)CCC[....
76 6G1W - E0Z C27 H25 Cl N6 O3 COc1cc(ccc....
77 5NAP Ki = 11.12 nM DZ7 C24 H27 N O3 COc1cc2c(c....
78 1H22 Ki = 0.8 nM E10 C28 H42 N4 O2 C1C[C@@H](....
79 5BWC Ki = 0.061 uM HBP C19 H26 N4 O2 c1cc[n+](c....
80 1GQR - SAF C10 H15 N O C[C@@H](c1....
81 1DX6 ic50 = 652 nM GNT C17 H21 N O3 C[N@@]1CC[....
82 2VJD - CCD C8 H20 N O C[C@H](CCC....
83 2V96 Ki = 29 uM CFQ C13 H19 As F3 N O3 C[As+](C)(....
84 5NAU Ki = 29.86 nM DZ0 C23 H25 N O2 COc1ccc2c(....
85 2VJA - CCD C8 H20 N O C[C@H](CCC....
86 1GPN Ki = 0.334 uM HUB C16 H20 N2 O CC1=C[C@H]....
87 6G1U - E1K C14 H16 Cl N2 C[n+]1c2cc....
88 1JJB - PE7 C14 H30 O7 S C(COCCOCCO....
89 6FQN - E2W C23 H27 Cl N4 O2 c1cc2c(cc1....
90 1E66 Ki = 0.13 nM HUX C18 H19 Cl N2 CCC1=C[C@@....
91 1ZGC ic50 = 38.8 nM A2E C32 H44 N4 O c1ccc2c(c1....
92 3I6M - G3X C24 H34 N2 O3 COc1ccc2c3....
93 6FLD - NAG C8 H15 N O6 CC(=O)N[C@....
94 6G1V - E1N C19 H22 Cl N2 CCC1=C[C@@....
95 1ZGB ic50 = 8.8 nM A1E C32 H44 N4 O c1ccc2c(c1....
96 1W4L ic50 = 4 nM GL8 C32 H37 N2 O5 COc1ccc2c3....
97 2C5G - ETM C5 H14 N S C[N+](C)(C....
98 3ZV7 - NHG C11 H14 N2 O C[C@@]12CC....
99 2CKM Kd = 77 fM AA7 C33 H40 N4 c1ccc2c(c1....
100 1W76 ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
101 1W6R ic50 = 702 nM GNT C17 H21 N O3 C[N@@]1CC[....
102 1MX1 - THA C13 H14 N2 c1ccc2c(c1....
103 2H7C - SIA C11 H19 N O9 CC(=O)N[C@....
104 1K4Y - 4PN C10 H20 N2 C1CCN(CC1)....
105 4EY5 - HUP C15 H18 N2 O C/C=C/1[C@....
106 6O4X - AA C13 H11 N2 c1ccc2c(c1....
107 4EY7 - E20 C24 H29 N O3 COc1cc2c(c....
108 4M0E Ki = 0.7 uM 1YL C18 H14 O3 Cc1cccc2c1....
109 6O66 - LND C13 H16 N5 O2 c1c[n+](cc....
110 6O50 - EBW C27 H38 N2 O C[N+](C)(C....
111 5HF9 - HI6 C14 H16 N4 O3 c1cc[n+](c....
112 6U34 Ki = 157 uM PQV C10 H19 N3 O2 C1CCCN(CC1....
113 5HFA - FP1 C7 H10 N2 O CN1C=CC=C/....
114 6O5V - LND C13 H16 N5 O2 c1c[n+](cc....
115 4EY6 - GNT C17 H21 N O3 C[N@@]1CC[....
116 6CQY - VX C3 H9 O3 P CCO[P@](=O....
117 6NEA - HLO C15 H17 N5 O4 c1c[n+](cc....
118 4M0F Ki = 1.7 nM 1YK C29 H34 O9 C[C@@]12CC....
119 6CQW Kd = 0.000000064 M HI6 C14 H16 N4 O3 c1cc[n+](c....
120 6O4W - E20 C24 H29 N O3 COc1cc2c(c....
121 6CQU - HI6 C14 H16 N4 O3 c1cc[n+](c....
122 6U37 - PQV C10 H19 N3 O2 C1CCCN(CC1....
123 6ARX - FLC C6 H5 O7 C(C(=O)[O-....
124 6ARY - FLC C6 H5 O7 C(C(=O)[O-....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: NAG; Similar ligands found: 80
No: Ligand ECFP6 Tc MDL keys Tc
1 A2G 1 1
2 HSQ 1 1
3 NAG 1 1
4 NGA 1 1
5 BM3 1 1
6 NDG 1 1
7 BGN 0.638298 0.888889
8 SIZ 0.630435 0.906977
9 YX1 0.625 0.65
10 STZ 0.612245 0.65
11 16G 0.591837 0.735849
12 4QY 0.591837 0.735849
13 BMX 0.591837 0.735849
14 9C1 0.58 0.886364
15 SNG 0.5625 0.866667
16 NG6 0.54902 0.661017
17 NGS 0.54902 0.661017
18 GDL NAG 0.54386 0.833333
19 ASG 0.538462 0.661017
20 BG8 0.537037 0.906977
21 MAG 0.530612 0.909091
22 2F8 0.530612 0.909091
23 NAG GAL 0.517857 0.888889
24 4V5 0.517241 0.829787
25 A2G NAG 0.517241 0.833333
26 MAN NAG 0.508772 0.888889
27 4UZ 0.508475 0.808511
28 NAG NAG NAG NAG NAG 0.508197 0.816327
29 NAG NAG NAG NAG NAG NAG 0.508197 0.816327
30 NAG NAG NAG NAG NAG NAG NAG NAG 0.508197 0.816327
31 NDG NAG NAG NAG NAG 0.508197 0.816327
32 MQG 0.5 0.698113
33 NBG 0.5 0.951219
34 BMX BMX BMX BM3 0.5 0.701754
35 A2G GAL 0.491228 0.888889
36 AMU 0.490909 0.930233
37 NG1 0.490566 0.754717
38 GN1 0.490566 0.754717
39 NDG NAG 0.47541 0.816327
40 GAL NAG 0.459016 0.888889
41 NAG GAL NAG 0.455882 0.833333
42 NAG FUC 0.45 0.888889
43 3YW 0.448276 0.930233
44 NAG GAL GAL 0.446154 0.888889
45 NAG NAG 0.430769 0.816327
46 GAL NGA 0.428571 0.869565
47 NAG G6S 0.426471 0.645161
48 NAG GAL FUC A2G 0.426471 0.869565
49 GYU 0.42623 0.740741
50 SER A2G 0.42623 0.816327
51 TNR 0.42623 0.833333
52 GAL NGA A2G 0.424242 0.833333
53 NAG BDP 0.421875 0.851064
54 MBG NAG 0.419355 0.851064
55 BGC GAL NGA 0.41791 0.888889
56 AZC 0.415094 0.795918
57 SN5 SN5 0.412698 0.705882
58 MBG A2G 0.412698 0.851064
59 6ZC 0.409091 0.655738
60 LEC 0.409091 0.655738
61 NAG GAL BGC GAL 0.408451 0.888889
62 NAG NAG NAG TMX 0.408451 0.689655
63 GLC 0.404762 0.7
64 GAL 0.404762 0.7
65 GIV 0.404762 0.7
66 BGC 0.404762 0.7
67 BMA 0.404762 0.7
68 WOO 0.404762 0.7
69 GAL GAL 0.404762 0.7
70 GLA 0.404762 0.7
71 MAN 0.404762 0.7
72 ALL 0.404762 0.7
73 BGC GAL 0.404762 0.7
74 GLC GLC 0.404762 0.7
75 GXL 0.404762 0.7
76 A2G GAL NAG 0.402778 0.833333
77 AMU NAG 0.402778 0.8
78 BMA MAN NAG 0.4 0.888889
79 NAG GAL FUC 0.4 0.869565
80 GAL FUC A2G 0.4 0.869565
Ligand no: 2; Ligand: DQ5; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 DQ5 1 1
2 F11 0.60241 0.642857
3 AA7 0.595238 0.642857
4 A8B 0.490196 0.642857
5 TZ2 0.489362 0.622951
6 E2W 0.463636 0.84127
Similar Ligands (3D)
Ligand no: 1; Ligand: NAG; Similar ligands found: 1459
No: Ligand Similarity coefficient
1 GDL 1.0000
2 8IG 1.0000
3 NOK 0.9985
4 LTM 0.9951
5 BEU 0.9950
6 LOG 0.9862
7 TNX 0.9842
8 BNX 0.9774
9 2CZ 0.9708
10 ALX 0.9666
11 NGT 0.9608
12 9H2 0.9576
13 IFG 0.9567
14 HQ6 0.9548
15 3ZB 0.9519
16 DJN 0.9512
17 ST2 0.9509
18 DNA 0.9506
19 4BY 0.9505
20 GJP 0.9496
21 4I8 0.9492
22 UNJ 0.9490
23 BBK 0.9487
24 Y0V 0.9480
25 NGW 0.9480
26 6KT 0.9468
27 4BL 0.9440
28 1HN 0.9439
29 GC3 0.9434
30 EE8 0.9432
31 86L 0.9428
32 6E8 0.9424
33 F34 0.9422
34 APS 0.9418
35 GNM 0.9417
36 8NX 0.9417
37 ARP 0.9412
38 68A 0.9411
39 K97 0.9410
40 H5B 0.9405
41 EPR 0.9403
42 MS9 0.9402
43 2FQ 0.9400
44 3R4 0.9400
45 S0G 0.9399
46 2KA 0.9394
47 OQC 0.9389
48 ZPF 0.9388
49 4RU 0.9387
50 57O 0.9385
51 27B 0.9383
52 GF4 0.9383
53 S7G 0.9382
54 PH2 0.9379
55 NGO 0.9378
56 428 0.9370
57 GC2 0.9370
58 344 0.9363
59 K82 0.9358
60 JTH 0.9358
61 HHS 0.9348
62 QX4 0.9347
63 S0E 0.9347
64 3VX 0.9345
65 5LA 0.9345
66 IV2 0.9332
67 9ZE 0.9330
68 S24 0.9326
69 PRF 0.9325
70 PLR 0.9324
71 KJ5 0.9321
72 1BW 0.9316
73 2JK 0.9316
74 8NB 0.9315
75 XM5 0.9314
76 FDR 0.9312
77 12T 0.9312
78 4AA 0.9309
79 HHR 0.9308
80 MD6 0.9305
81 HQD 0.9305
82 QIV 0.9299
83 94W 0.9290
84 3QV 0.9290
85 3XR 0.9286
86 KMY 0.9284
87 54Z 0.9282
88 LP8 0.9279
89 BPU 0.9278
90 B62 0.9276
91 5RO 0.9276
92 DQU 0.9275
93 1F1 0.9273
94 QBK 0.9267
95 EV2 0.9267
96 0HN 0.9267
97 RH1 0.9263
98 0FN 0.9262
99 9R5 0.9261
100 15N 0.9261
101 GHM 0.9261
102 BZJ 0.9256
103 SYA 0.9255
104 HBO 0.9255
105 S8A 0.9250
106 6ME 0.9248
107 DK1 0.9247
108 0N7 0.9247
109 JTA 0.9247
110 EUE 0.9246
111 PNZ 0.9245
112 JP2 0.9243
113 LIP 0.9240
114 CFA 0.9240
115 A7H 0.9240
116 ANN 0.9238
117 GO2 0.9238
118 GNV 0.9233
119 NFM 0.9232
120 FLV 0.9232
121 F2W 0.9231
122 BGU 0.9230
123 5TY 0.9229
124 5NI 0.9229
125 6NT 0.9229
126 HKD 0.9228
127 6FB 0.9226
128 3NY 0.9226
129 J6W 0.9223
130 GNL 0.9223
131 0FK 0.9220
132 YO5 0.9220
133 L1Q 0.9219
134 IAC 0.9219
135 W81 0.9218
136 P9E 0.9217
137 PQ0 0.9216
138 XHP 0.9215
139 D6G 0.9215
140 2ZM 0.9215
141 9KZ 0.9212
142 TSR 0.9211
143 KYA 0.9211
144 S60 0.9210
145 7MX 0.9209
146 44V 0.9206
147 1KP 0.9205
148 61M 0.9205
149 2FY 0.9204
150 OTW 0.9203
151 N2M 0.9201
152 ES2 0.9201
153 F4K 0.9200
154 KJU 0.9199
155 ZZZ 0.9198
156 44W 0.9197
157 K3Q 0.9196
158 CWJ 0.9196
159 6VD 0.9195
160 4TU 0.9194
161 KTW 0.9194
162 BHQ 0.9193
163 0HO 0.9191
164 SG2 0.9191
165 PRL 0.9189
166 0JD 0.9188
167 549 0.9186
168 BDP 0.9186
169 327 0.9185
170 THA 0.9183
171 GZQ 0.9183
172 DRG 0.9182
173 N2I 0.9181
174 UFO 0.9180
175 MP5 0.9180
176 X0U 0.9179
177 ESX 0.9179
178 JAW 0.9179
179 CLZ 0.9178
180 X1P 0.9176
181 XAZ 0.9176
182 AJV 0.9175
183 BZ2 0.9175
184 SNO 0.9174
185 2K8 0.9171
186 P80 0.9171
187 RNO 0.9171
188 L1O 0.9170
189 54X 0.9170
190 PQK 0.9169
191 V1T 0.9169
192 9KH 0.9169
193 5FN 0.9168
194 A7N 0.9167
195 6FZ 0.9167
196 8WO 0.9166
197 CTS 0.9166
198 X0W 0.9165
199 1A7 0.9164
200 8HC 0.9163
201 BA5 0.9162
202 4JQ 0.9162
203 3C4 0.9160
204 R9Y 0.9160
205 5JQ 0.9160
206 EYV 0.9159
207 CKA 0.9159
208 I3E 0.9159
209 MUR 0.9158
210 R1P 0.9158
211 4HP 0.9158
212 TXW 0.9156
213 5NE 0.9154
214 DHY 0.9154
215 HHT 0.9154
216 LZ2 0.9153
217 0F9 0.9153
218 MNS 0.9152
219 L46 0.9152
220 PQZ 0.9152
221 AH9 0.9152
222 AA 0.9151
223 YTX 0.9151
224 HNT 0.9150
225 ANF 0.9150
226 PYU 0.9150
227 BPY 0.9149
228 JU2 0.9149
229 3MG 0.9148
230 15E 0.9148
231 Y3L 0.9148
232 PMP 0.9146
233 PLP PMP 0.9146
234 PZP 0.9146
235 209 0.9145
236 363 0.9144
237 3A9 0.9144
238 4YO 0.9143
239 KJY 0.9141
240 FTV 0.9141
241 AZ9 0.9140
242 7ME 0.9140
243 VXX 0.9139
244 TWO 0.9137
245 IQ5 0.9135
246 AU8 0.9134
247 A6W 0.9134
248 0W1 0.9132
249 B4O 0.9132
250 E1K 0.9130
251 E1T 0.9130
252 GCU 0.9130
253 ZYR 0.9129
254 TGX 0.9129
255 UA5 0.9127
256 L7T 0.9127
257 KDV 0.9126
258 5NS 0.9124
259 NSG 0.9124
260 BQ2 0.9123
261 ST1 0.9122
262 LDP 0.9120
263 7B3 0.9120
264 NLA 0.9120
265 54E 0.9119
266 226 0.9119
267 KW8 0.9118
268 PLP 0.9118
269 5OO 0.9117
270 JG8 0.9116
271 80G 0.9116
272 SKF 0.9115
273 N91 0.9115
274 CXH 0.9114
275 SBK 0.9113
276 AN3 0.9113
277 463 0.9112
278 URC 0.9112
279 I6G 0.9112
280 BTY 0.9111
281 8W9 0.9111
282 5GT 0.9111
283 3N1 0.9110
284 492 0.9109
285 0FO 0.9108
286 CN0 0.9108
287 I4D 0.9107
288 ESP 0.9106
289 TYL 0.9106
290 MVN 0.9105
291 AEH 0.9105
292 TIY 0.9105
293 DIN 0.9105
294 5WU 0.9104
295 NOJ 0.9104
296 75K 0.9103
297 0OK 0.9103
298 DNF 0.9102
299 MAJ 0.9101
300 1P8 0.9100
301 2GQ 0.9100
302 E7S 0.9099
303 5VM 0.9099
304 3TC 0.9097
305 MQN 0.9097
306 8ZE 0.9097
307 ST3 0.9096
308 5JL 0.9096
309 8MO 0.9096
310 HRM 0.9095
311 H7Y 0.9091
312 DHB 0.9091
313 3VS 0.9091
314 BIK 0.9089
315 MSR 0.9087
316 PXP 0.9086
317 G1P 0.9085
318 PEY 0.9085
319 6NI 0.9084
320 BEA 0.9084
321 GSY 0.9083
322 ODO 0.9083
323 0J4 0.9082
324 N4E 0.9082
325 SLS 0.9081
326 CLW 0.9081
327 PH3 0.9080
328 TOF 0.9080
329 K4V 0.9078
330 AY4 0.9077
331 GNY 0.9077
332 C1M 0.9077
333 K32 0.9077
334 2FX 0.9077
335 RKV 0.9076
336 AMR 0.9076
337 FF2 0.9075
338 PFL 0.9075
339 X04 0.9074
340 88L 0.9074
341 ESI 0.9074
342 IHB 0.9074
343 OKM 0.9073
344 0J5 0.9073
345 14W 0.9073
346 INO 0.9073
347 JXZ 0.9072
348 N1E 0.9072
349 8MP 0.9072
350 NHT 0.9072
351 6RQ 0.9071
352 0TU 0.9071
353 6HP 0.9069
354 KGK 0.9068
355 F1A 0.9067
356 3J8 0.9066
357 657 0.9064
358 VGD 0.9064
359 AJG 0.9064
360 CSN 0.9063
361 VM1 0.9062
362 3DM 0.9061
363 ICB 0.9060
364 2QC 0.9060
365 2A9 0.9059
366 K2T 0.9059
367 JDN 0.9059
368 TYE 0.9057
369 DHC 0.9057
370 BNT 0.9056
371 BCU 0.9056
372 LDR 0.9056
373 AEG 0.9056
374 GRX 0.9056
375 36R 0.9056
376 INE 0.9056
377 1FD 0.9055
378 4ME 0.9055
379 C2Y 0.9055
380 7FF 0.9055
381 2EC 0.9053
382 FBB 0.9053
383 N3W 0.9052
384 4MU 0.9052
385 RVE 0.9051
386 NVU 0.9050
387 APZ 0.9050
388 C8O 0.9049
389 B41 0.9049
390 1FE 0.9049
391 DDU 0.9048
392 F52 0.9047
393 9AP 0.9047
394 CP7 0.9047
395 9FH 0.9046
396 IOS 0.9045
397 EOL 0.9045
398 I59 0.9045
399 HA5 0.9045
400 5OF 0.9045
401 C9E 0.9044
402 42J 0.9043
403 ET2 0.9043
404 LI6 0.9041
405 CPZ 0.9041
406 7I2 0.9041
407 IBM 0.9040
408 B56 0.9040
409 2HQ 0.9039
410 8TX 0.9039
411 JA8 0.9039
412 EXD 0.9039
413 SNU 0.9039
414 OW7 0.9039
415 N8Y 0.9038
416 JF1 0.9037
417 H33 0.9037
418 4NO 0.9037
419 36M 0.9035
420 ABI 0.9035
421 EUG 0.9035
422 HDL 0.9033
423 LQ2 0.9033
424 7W1 0.9032
425 L99 0.9031
426 ANC 0.9031
427 2HU 0.9030
428 67X 0.9028
429 M5H 0.9028
430 97T 0.9028
431 NBV 0.9027
432 EVF 0.9027
433 93K 0.9027
434 ZEC 0.9024
435 4NP 0.9024
436 GDE 0.9024
437 2LY 0.9023
438 JCZ 0.9023
439 6QF 0.9022
440 MJ5 0.9022
441 N7I 0.9021
442 NB1 0.9021
443 K7H 0.9021
444 15L 0.9020
445 TMG 0.9020
446 VK3 0.9020
447 HC4 0.9020
448 B55 0.9019
449 5QX 0.9019
450 4R1 0.9018
451 2P3 0.9018
452 JXK 0.9017
453 8U3 0.9017
454 4NS 0.9017
455 TZF 0.9017
456 505 0.9016
457 MUA 0.9016
458 ONR 0.9015
459 K68 0.9014
460 VOH 0.9012
461 FHB 0.9012
462 5GU 0.9012
463 9KT 0.9011
464 TSS 0.9011
465 2C2 0.9011
466 948 0.9010
467 4A5 0.9010
468 A7W 0.9010
469 B5D 0.9010
470 1IT 0.9010
471 QMS 0.9010
472 9FL 0.9010
473 JF2 0.9009
474 GLP 0.9009
475 EN1 0.9009
476 P7Y 0.9008
477 537 0.9008
478 36Y 0.9008
479 IPD 0.9007
480 DVQ 0.9007
481 5F5 0.9006
482 7FU 0.9006
483 PFB 0.9006
484 PHE 0.9006
485 XQI 0.9005
486 XCG 0.9005
487 X05 0.9005
488 4NC 0.9005
489 CIY 0.9005
490 AQO 0.9004
491 D48 0.9004
492 3HM 0.9004
493 4KL 0.9004
494 A5E 0.9004
495 F5C 0.9003
496 3Y7 0.9003
497 X0T 0.9002
498 VC3 0.9002
499 QSB 0.9002
500 AES 0.9001
501 SJK 0.9000
502 2GS 0.8999
503 HDH 0.8999
504 S7J 0.8999
505 1SS 0.8998
506 K22 0.8998
507 92P 0.8998
508 SYV 0.8997
509 MFZ 0.8997
510 4NM 0.8997
511 CHB 0.8997
512 OIA 0.8996
513 E7R 0.8995
514 89J 0.8995
515 J9Q 0.8995
516 1M2 0.8995
517 NID 0.8994
518 JLZ 0.8994
519 IFP 0.8994
520 E7Z 0.8993
521 UAN 0.8993
522 AX3 0.8993
523 YF3 0.8993
524 6X9 0.8993
525 6ZW 0.8991
526 GF1 0.8991
527 OA3 0.8990
528 BY5 0.8989
529 HCT 0.8989
530 4A3 0.8988
531 9NB 0.8988
532 3GQ 0.8987
533 39O 0.8987
534 EWG 0.8986
535 4NB 0.8986
536 PPN 0.8985
537 SYE 0.8984
538 MEW 0.8984
539 9TW 0.8983
540 BPN 0.8983
541 XYH 0.8982
542 NQ 0.8981
543 AJ2 0.8981
544 RXA 0.8980
545 4Z4 0.8980
546 TT4 0.8980
547 JXW 0.8978
548 30G 0.8978
549 EVA 0.8978
550 DEW 0.8977
551 VNL 0.8977
552 GXY 0.8974
553 0FR 0.8974
554 2BX 0.8973
555 2AK 0.8972
556 8XL 0.8972
557 8XQ 0.8972
558 Z5P 0.8972
559 LTT 0.8970
560 AH6 0.8970
561 A29 0.8970
562 Q24 0.8969
563 J9W 0.8968
564 IOP 0.8968
565 IFL 0.8968
566 KP2 0.8967
567 H4E 0.8967
568 TTL 0.8967
569 TTY 0.8966
570 M5K 0.8966
571 2O6 0.8965
572 9BF 0.8965
573 JA5 0.8965
574 TYR 0.8965
575 PXL 0.8964
576 2D2 0.8964
577 NNO 0.8964
578 E5X 0.8963
579 L21 0.8962
580 KF5 0.8962
581 ZB1 0.8962
582 TR4 0.8962
583 MOK 0.8962
584 9CA 0.8962
585 GNJ 0.8961
586 LCN 0.8960
587 GLO 0.8960
588 Q71 0.8959
589 9LI 0.8959
590 MRW 0.8958
591 SQV 0.8958
592 2HO 0.8958
593 RD4 0.8958
594 ASO 0.8957
595 CKU 0.8957
596 LPK 0.8955
597 I2E 0.8955
598 DPT 0.8955
599 LNR 0.8954
600 H4B 0.8953
601 TRP 0.8953
602 X09 0.8953
603 YI6 0.8953
604 20J 0.8953
605 86J 0.8952
606 GO8 0.8952
607 ALE 0.8952
608 XDE 0.8952
609 HJ7 0.8952
610 M3Q 0.8952
611 P9P 0.8952
612 5XC 0.8951
613 HWD 0.8950
614 790 0.8950
615 VPU 0.8950
616 HBI 0.8950
617 J5I 0.8949
618 BHA 0.8949
619 JYT 0.8948
620 JB8 0.8947
621 4FE 0.8947
622 N0Z 0.8947
623 94B 0.8946
624 M4E 0.8946
625 DI6 0.8945
626 DPZ 0.8945
627 DOB 0.8945
628 X48 0.8944
629 9FE 0.8944
630 12Q 0.8943
631 0UL 0.8943
632 3PF 0.8942
633 P84 0.8942
634 SRO 0.8941
635 0LH 0.8941
636 8WT 0.8941
637 TCR 0.8940
638 FPL 0.8940
639 3RI 0.8939
640 MO8 0.8939
641 GT0 0.8939
642 JAH 0.8939
643 MYJ 0.8939
644 G6P 0.8939
645 CH8 0.8939
646 4JC 0.8938
647 2JX 0.8938
648 BIO 0.8938
649 7VS 0.8938
650 FIX 0.8937
651 NOY 0.8937
652 4HC 0.8936
653 82I 0.8936
654 ZON 0.8936
655 K25 0.8936
656 G2F 0.8936
657 GB4 0.8935
658 HNQ 0.8935
659 L14 0.8934
660 2WU 0.8934
661 AAN 0.8933
662 HXY 0.8933
663 SKM 0.8933
664 H2B 0.8932
665 MQB 0.8932
666 ISD 0.8932
667 4AB 0.8931
668 MNM 0.8931
669 PJW 0.8930
670 DHK 0.8929
671 4NZ 0.8929
672 AMH 0.8926
673 PE0 0.8926
674 2O8 0.8925
675 G3E 0.8925
676 OHP 0.8925
677 P81 0.8925
678 ICO 0.8925
679 AJ1 0.8924
680 EUH 0.8924
681 SE2 0.8924
682 OMD 0.8924
683 4XV 0.8923
684 92O 0.8923
685 5V7 0.8922
686 M78 0.8922
687 5GV 0.8921
688 HQT 0.8920
689 R20 0.8920
690 YRL 0.8920
691 6HO 0.8920
692 XX2 0.8920
693 B52 0.8919
694 1QP 0.8919
695 BP7 0.8919
696 2UZ 0.8918
697 F31 0.8918
698 4MB 0.8917
699 RSV 0.8917
700 7AP 0.8916
701 ASC 0.8916
702 4BZ 0.8916
703 7QD 0.8915
704 RA7 0.8915
705 AP4 0.8914
706 GCB 0.8914
707 PNP 0.8913
708 36E 0.8913
709 ABF 0.8912
710 EAE 0.8912
711 3UG 0.8912
712 4WL 0.8912
713 PA1 0.8911
714 HPP 0.8910
715 CX4 0.8910
716 EMZ 0.8909
717 2HC 0.8909
718 MS0 0.8908
719 KIB 0.8908
720 M6Z 0.8908
721 2F6 0.8906
722 4OG 0.8906
723 06B 0.8906
724 KWH 0.8905
725 2BG 0.8905
726 G12 0.8905
727 O2A 0.8905
728 C82 0.8904
729 AJY 0.8904
730 AZ8 0.8904
731 CIP 0.8903
732 CH9 0.8903
733 S0W 0.8903
734 CGW 0.8901
735 UQ1 0.8901
736 PW1 0.8901
737 0XT 0.8901
738 PD2 0.8901
739 XEN 0.8901
740 22L 0.8900
741 PPT 0.8900
742 LFQ 0.8899
743 P0P 0.8899
744 PYQ 0.8898
745 KLK 0.8898
746 HQJ 0.8898
747 J9N 0.8898
748 CR1 0.8897
749 7MW 0.8897
750 3VQ 0.8897
751 HHH 0.8897
752 X0V 0.8896
753 GWM 0.8896
754 QSH 0.8896
755 BK9 0.8895
756 259 0.8895
757 WS7 0.8895
758 2LB 0.8893
759 5WZ 0.8893
760 8D6 0.8893
761 GVY 0.8893
762 IWT 0.8893
763 49O 0.8892
764 XIY 0.8892
765 SSC 0.8891
766 F9Y 0.8891
767 JBZ 0.8891
768 4M0 0.8891
769 JVN 0.8891
770 8CM 0.8890
771 F1X 0.8889
772 F4E 0.8889
773 LEL 0.8887
774 DNC 0.8887
775 TZM 0.8887
776 9GP 0.8886
777 4FF 0.8886
778 SKA 0.8885
779 NPA 0.8885
780 FHC 0.8885
781 Z21 0.8884
782 LYL 0.8883
783 6DP 0.8883
784 B57 0.8883
785 UQ 0.8883
786 VUP 0.8882
787 J9T 0.8882
788 LZB 0.8881
789 ZSP 0.8881
790 C53 0.8880
791 IL5 0.8880
792 BPW 0.8880
793 FYR 0.8879
794 FA0 0.8879
795 CPW 0.8878
796 RAT 0.8878
797 JND 0.8878
798 M4S 0.8878
799 AC2 0.8878
800 REL 0.8877
801 EGR 0.8877
802 DEE 0.8877
803 FRU 0.8875
804 SOE 0.8875
805 A1Y 0.8875
806 1U6 0.8875
807 S98 0.8875
808 4SX 0.8875
809 MR1 0.8874
810 STT 0.8873
811 4XS 0.8872
812 3W8 0.8872
813 TAG 0.8872
814 TLG 0.8872
815 39U 0.8871
816 LL1 0.8871
817 EV3 0.8870
818 PXM 0.8870
819 0P6 0.8870
820 FBF 0.8870
821 MNP 0.8869
822 2CL 0.8869
823 5VL 0.8868
824 1XA 0.8868
825 9UL 0.8867
826 RKN 0.8867
827 KP6 0.8867
828 ADA 0.8866
829 XFE 0.8866
830 FUD 0.8866
831 YZ9 0.8866
832 4JE 0.8865
833 5QY 0.8865
834 CG 0.8864
835 21D 0.8864
836 7O4 0.8864
837 28N 0.8864
838 EYY 0.8864
839 ENO 0.8864
840 4V6 0.8863
841 3LJ 0.8863
842 BG6 0.8863
843 CK2 0.8863
844 AFR 0.8862
845 091 0.8862
846 NHG 0.8862
847 ZHA 0.8861
848 DC5 0.8861
849 PPY 0.8861
850 XQ0 0.8860
851 52C 0.8859
852 BZ3 0.8859
853 Z13 0.8859
854 4P5 0.8859
855 4VY 0.8858
856 C93 0.8857
857 FQX 0.8857
858 H42 0.8857
859 K3D 0.8857
860 JWB 0.8855
861 ZXD 0.8854
862 KUF 0.8854
863 XX3 0.8853
864 DX3 0.8853
865 5CU 0.8853
866 6Q3 0.8852
867 XQK 0.8852
868 JYB 0.8852
869 PVQ 0.8852
870 PFF 0.8851
871 BHS 0.8851
872 5GL 0.8849
873 YPN 0.8849
874 92G 0.8849
875 ICT 0.8849
876 GCS 0.8849
877 PRZ 0.8848
878 N2Z 0.8847
879 55D 0.8847
880 3Z8 0.8847
881 DRL 0.8846
882 L5V 0.8846
883 4ZA 0.8846
884 DTY 0.8846
885 5RN 0.8845
886 FGZ 0.8845
887 7MU 0.8844
888 L1T 0.8844
889 67Y 0.8843
890 K37 0.8842
891 96R 0.8841
892 FMQ 0.8841
893 HA7 0.8840
894 CWS 0.8840
895 WSD 0.8840
896 JXN 0.8839
897 PVK 0.8839
898 OUB 0.8839
899 CIT 0.8839
900 BQ5 0.8838
901 78Y 0.8838
902 LR5 0.8838
903 4CM 0.8837
904 2J2 0.8837
905 LGC 0.8837
906 I3A 0.8837
907 3AE 0.8836
908 EYJ 0.8836
909 MIG 0.8835
910 A4N 0.8835
911 AEF 0.8834
912 RZH 0.8833
913 JRB 0.8833
914 CTE 0.8833
915 B2Y 0.8833
916 PUE 0.8832
917 KLV 0.8832
918 DTR 0.8831
919 7L4 0.8830
920 4XF 0.8829
921 5RP 0.8829
922 L07 0.8829
923 G3F 0.8829
924 FLC 0.8829
925 5PX 0.8828
926 AM4 0.8828
927 CLU 0.8827
928 R9S 0.8827
929 CNI 0.8827
930 NIY 0.8827
931 4FA 0.8827
932 NCV 0.8826
933 SWX 0.8826
934 CC5 0.8825
935 F69 0.8825
936 K48 0.8824
937 Q77 0.8824
938 DHR 0.8824
939 CUT 0.8824
940 1A5 0.8824
941 A6P 0.8823
942 H75 0.8823
943 ES5 0.8823
944 2L3 0.8823
945 5OB 0.8822
946 8S0 0.8822
947 5WY 0.8821
948 2UB 0.8821
949 8GK 0.8820
950 SHG 0.8820
951 FWD 0.8819
952 HPT 0.8818
953 AVA 0.8818
954 SN4 0.8818
955 5WT 0.8818
956 46M 0.8817
957 A5P 0.8815
958 HNK 0.8815
959 LVD 0.8815
960 X11 0.8814
961 FDB 0.8814
962 6J9 0.8813
963 TEP 0.8813
964 X8D 0.8812
965 LR8 0.8812
966 PDC 0.8812
967 ZZA 0.8810
968 0NX 0.8809
969 FT6 0.8809
970 977 0.8809
971 KIA 0.8808
972 1CY 0.8808
973 9PY 0.8808
974 MIL 0.8808
975 ROI 0.8808
976 E35 0.8807
977 27K 0.8807
978 NLQ 0.8806
979 03V 0.8806
980 4FS 0.8806
981 HLZ 0.8806
982 2AL 0.8806
983 PHB 0.8806
984 OW4 0.8806
985 QIC 0.8805
986 2J9 0.8805
987 6BL 0.8804
988 HSX 0.8804
989 G14 0.8804
990 MZM 0.8803
991 X8Z 0.8803
992 92K 0.8803
993 SQ7 0.8803
994 AZM 0.8803
995 PBA 0.8803
996 DAH 0.8802
997 UFV 0.8802
998 M6P 0.8801
999 P4L 0.8801
1000 7ZE 0.8801
1001 1X7 0.8801
1002 S3C 0.8800
1003 AVO 0.8800
1004 OTD 0.8799
1005 CP6 0.8798
1006 1QV 0.8798
1007 4LW 0.8798
1008 535 0.8798
1009 3R6 0.8798
1010 QME 0.8796
1011 37T 0.8795
1012 JY2 0.8795
1013 1Z6 0.8794
1014 1WC 0.8794
1015 SHA 0.8793
1016 MHK 0.8792
1017 5VJ 0.8792
1018 3SU 0.8791
1019 1DR 0.8791
1020 BGP 0.8791
1021 CEG 0.8790
1022 LUM 0.8790
1023 1L5 0.8790
1024 AH3 0.8789
1025 3JM 0.8788
1026 64C 0.8787
1027 GTR 0.8787
1028 CCV 0.8786
1029 PQS 0.8786
1030 HQ9 0.8786
1031 3TV 0.8785
1032 CHQ 0.8785
1033 IPB 0.8784
1034 HRD 0.8784
1035 AC6 0.8784
1036 0F3 0.8783
1037 MXD 0.8783
1038 JR2 0.8783
1039 4BX 0.8783
1040 OVM 0.8783
1041 6TZ 0.8783
1042 069 0.8783
1043 YIE 0.8782
1044 B60 0.8782
1045 GJK 0.8781
1046 E4P 0.8781
1047 GCV 0.8781
1048 KBZ 0.8780
1049 GLF 0.8779
1050 3VW 0.8779
1051 OCH 0.8779
1052 EKZ 0.8779
1053 46P 0.8778
1054 3IT 0.8778
1055 M1Q 0.8777
1056 4FH 0.8777
1057 ZZT 0.8777
1058 CWD 0.8776
1059 FCW 0.8776
1060 DA4 0.8776
1061 AZY 0.8775
1062 M2K 0.8775
1063 6P3 0.8775
1064 2AQ 0.8775
1065 3MB 0.8774
1066 878 0.8774
1067 HJH 0.8773
1068 TLM 0.8773
1069 K17 0.8773
1070 ONZ 0.8773
1071 CS2 0.8772
1072 5FL 0.8771
1073 F6P 0.8771
1074 OTR 0.8771
1075 3TJ 0.8771
1076 40F 0.8771
1077 COU 0.8770
1078 6ZX 0.8769
1079 LAO 0.8769
1080 ZYQ 0.8768
1081 E1P 0.8768
1082 GZL 0.8768
1083 SLC 0.8767
1084 FER 0.8766
1085 PBZ 0.8766
1086 QAS 0.8764
1087 7B4 0.8764
1088 FCD 0.8764
1089 UEG 0.8763
1090 PZM 0.8763
1091 5SP 0.8762
1092 HX3 0.8762
1093 ES7 0.8762
1094 LO1 0.8762
1095 7VP 0.8762
1096 M1Z 0.8761
1097 4CF 0.8761
1098 QQQ 0.8761
1099 MPV 0.8761
1100 L22 0.8760
1101 DY5 0.8760
1102 8H8 0.8760
1103 4V2 0.8759
1104 MMS 0.8759
1105 GT4 0.8757
1106 CFF 0.8757
1107 4JT 0.8757
1108 BWD 0.8756
1109 5NU 0.8756
1110 4VS 0.8755
1111 6DQ 0.8755
1112 5F8 0.8755
1113 E9P 0.8755
1114 2D3 0.8754
1115 293 0.8754
1116 ITE 0.8754
1117 I3C 0.8754
1118 XDK 0.8753
1119 3W3 0.8753
1120 2ZQ 0.8753
1121 4AN 0.8753
1122 BRV 0.8753
1123 TL6 0.8753
1124 L03 0.8753
1125 PQM 0.8753
1126 KOJ 0.8753
1127 GI3 0.8752
1128 BDF 0.8752
1129 173 0.8752
1130 3W6 0.8751
1131 KDG 0.8751
1132 NPO 0.8751
1133 KYN 0.8751
1134 4AF 0.8749
1135 EXR 0.8748
1136 LT2 0.8747
1137 KKN 0.8746
1138 ODK 0.8746
1139 3IL 0.8745
1140 9F8 0.8744
1141 BL0 0.8743
1142 AWE 0.8743
1143 DQA 0.8743
1144 NDM 0.8743
1145 CKX 0.8742
1146 A4T 0.8742
1147 NAL 0.8742
1148 OSB 0.8742
1149 B53 0.8742
1150 795 0.8741
1151 7MK 0.8740
1152 F40 0.8740
1153 GLT 0.8738
1154 EZL 0.8738
1155 JMG 0.8738
1156 E3D 0.8737
1157 NCD 0.8737
1158 QBP 0.8736
1159 52F 0.8736
1160 A5H 0.8736
1161 6SD 0.8736
1162 BZE 0.8734
1163 3AK 0.8734
1164 3HA 0.8733
1165 OVP 0.8733
1166 4HM 0.8732
1167 HNH 0.8732
1168 NRA 0.8732
1169 AMS 0.8731
1170 KG1 0.8728
1171 PRO GLY 0.8728
1172 60Q 0.8728
1173 K44 0.8727
1174 5WV 0.8727
1175 JO5 0.8727
1176 SAF 0.8727
1177 PAB 0.8727
1178 D3G 0.8726
1179 51Y 0.8726
1180 G5V 0.8724
1181 KFH 0.8724
1182 KIF 0.8724
1183 HX4 0.8723
1184 FSW 0.8722
1185 YZM 0.8722
1186 NDD 0.8722
1187 NPS 0.8720
1188 SDD 0.8720
1189 SOR 0.8719
1190 KBG 0.8718
1191 A9K 0.8717
1192 GCW 0.8717
1193 FXH 0.8717
1194 Z82 0.8717
1195 TQU 0.8716
1196 39Z 0.8716
1197 2H5 0.8715
1198 ZYX 0.8715
1199 GIM 0.8715
1200 DCZ 0.8714
1201 PO6 0.8714
1202 BNL 0.8714
1203 XI7 0.8714
1204 7EL 0.8713
1205 RM1 0.8713
1206 WUB 0.8713
1207 4BF 0.8713
1208 M0Q 0.8713
1209 61O 0.8712
1210 FYU 0.8712
1211 X6P 0.8710
1212 JVS 0.8710
1213 5TZ