Receptor
PDB id Resolution Class Description Source Keywords
6NN4 2.15 Å EC: 2.7.1.40 THE STRUCTURE OF HUMAN LIVER PYRUVATE KINASE, HLPYK-D499N, I WITH FRU-1,6-BP HOMO SAPIENS PYRUVATE KINASE ALLOSTERIC GLYCOLYSIS TRANSFERASE
Ref.: CHANGES IN THE ALLOSTERIC SITE OF HUMAN LIVER PYRUV KINASE UPON ACTIVATOR BINDING INCLUDE THE BREAKAGE INTERSUBUNIT CATION-PI BOND. ACTA CRYSTALLOGR.,SECT.F V. 75 461 2019
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EDO C:602;
A:603;
B:602;
A:602;
D:603;
D:604;
D:602;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
none;
none;
none;
none;
none;
none;
none;
submit data
62.068 C2 H6 O2 C(CO)...
PEP A:604;
C:603;
B:603;
D:605;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
168.042 C3 H5 O6 P C=C(C...
FBP C:601;
D:601;
B:601;
A:601;
Valid;
Valid;
Valid;
Valid;
none;
none;
none;
none;
submit data
340.116 C6 H14 O12 P2 C([C@...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4IP7 1.8 Å EC: 2.7.1.40 STRUCTURE OF THE S12D VARIANT OF HUMAN LIVER PYRUVATE KINASE COMPLEX WITH CITRATE AND FBP. HOMO SAPIENS KINASE GLYCOLYSIS ALLOSTERIC PHOSPHORYLATION MIMIC LIVERTRANSFERASE
Ref.: ENERGETIC COUPLING BETWEEN AN OXIDIZABLE CYSTEINE A PHOSPHORYLATABLE N-TERMINUS OF HUMAN LIVER PYRUVATE BIOCHEMISTRY V. 52 466 2013
Members (5)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 6ECH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
2 6ECK - FBP C6 H14 O12 P2 C([C@@H]1[....
3 4IP7 - FBP C6 H14 O12 P2 C([C@@H]1[....
4 4IMA - FLC C6 H5 O7 C(C(=O)[O-....
5 6NN4 - PEP C3 H5 O6 P C=C(C(=O)O....
70% Homology Family (24)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 5 families.
1 6NU5 - OXL C2 O4 C(=O)(C(=O....
2 3BJF - FBP C6 H14 O12 P2 C([C@@H]1[....
3 6B6U - OXL C2 O4 C(=O)(C(=O....
4 4QG8 - MLI C3 H2 O4 C(C(=O)[O-....
5 6WP3 - OXL C2 O4 C(=O)(C(=O....
6 4JPG - 1OX C16 H12 N4 O c1ccc2c(c1....
7 4G1N - NZT C24 H22 N6 O3 S c1cc2cccnc....
8 6V74 Kd = 27 uM ASN C4 H8 N2 O3 C([C@@H](C....
9 1A49 - OXL C2 O4 C(=O)(C(=O....
10 2G50 - PYR C3 H4 O3 CC(=O)C(=O....
11 6WP5 Kd = 1 uM FBP C6 H14 O12 P2 C([C@@H]1[....
12 6GG4 - PHE C9 H11 N O2 c1ccc(cc1)....
13 6WP6 - OXL C2 O4 C(=O)(C(=O....
14 5X1V - FBP C6 H14 O12 P2 C([C@@H]1[....
15 6WP4 - OXL C2 O4 C(=O)(C(=O....
16 6NU1 - CYS C3 H7 N O2 S C([C@@H](C....
17 3N25 - PRO C5 H9 N O2 C1C[C@H](N....
18 1A5U - OXL C2 O4 C(=O)(C(=O....
19 6NUB - SER C3 H7 N O3 C([C@@H](C....
20 6ECH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
21 6ECK - FBP C6 H14 O12 P2 C([C@@H]1[....
22 4IP7 - FBP C6 H14 O12 P2 C([C@@H]1[....
23 4IMA - FLC C6 H5 O7 C(C(=O)[O-....
24 6NN4 - PEP C3 H5 O6 P C=C(C(=O)O....
50% Homology Family (38)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 6NU5 - OXL C2 O4 C(=O)(C(=O....
2 3BJF - FBP C6 H14 O12 P2 C([C@@H]1[....
3 6B6U - OXL C2 O4 C(=O)(C(=O....
4 4QG8 - MLI C3 H2 O4 C(C(=O)[O-....
5 6WP3 - OXL C2 O4 C(=O)(C(=O....
6 4JPG - 1OX C16 H12 N4 O c1ccc2c(c1....
7 4G1N - NZT C24 H22 N6 O3 S c1cc2cccnc....
8 6V74 Kd = 27 uM ASN C4 H8 N2 O3 C([C@@H](C....
9 1A49 - OXL C2 O4 C(=O)(C(=O....
10 2G50 - PYR C3 H4 O3 CC(=O)C(=O....
11 6WP5 Kd = 1 uM FBP C6 H14 O12 P2 C([C@@H]1[....
12 6GG4 - PHE C9 H11 N O2 c1ccc(cc1)....
13 6WP6 - OXL C2 O4 C(=O)(C(=O....
14 5X1V - FBP C6 H14 O12 P2 C([C@@H]1[....
15 6WP4 - OXL C2 O4 C(=O)(C(=O....
16 6NU1 - CYS C3 H7 N O2 S C([C@@H](C....
17 3N25 - PRO C5 H9 N O2 C1C[C@H](N....
18 1A5U - OXL C2 O4 C(=O)(C(=O....
19 6NUB - SER C3 H7 N O3 C([C@@H](C....
20 6QXL - G6P C6 H13 O9 P C([C@@H]1[....
21 5WSC - G6P C6 H13 O9 P C([C@@H]1[....
22 5WSB - G6P C6 H13 O9 P C([C@@H]1[....
23 5WS9 - OXL C2 O4 C(=O)(C(=O....
24 3QV9 - QV7 C22 H16 N4 O13 S4 c1cc(ccc1/....
25 6ECH - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
26 6ECK - FBP C6 H14 O12 P2 C([C@@H]1[....
27 4IP7 - FBP C6 H14 O12 P2 C([C@@H]1[....
28 4IMA - FLC C6 H5 O7 C(C(=O)[O-....
29 6NN4 - PEP C3 H5 O6 P C=C(C(=O)O....
30 3HQP - FDP C6 H14 O12 P2 C([C@@H]1[....
31 3QV8 - S62 C7 H5 N O6 S3 c1cc2c(cc1....
32 3PP7 - SVR C51 H40 N6 O23 S6 Cc1ccc(cc1....
33 4KCV - FDP C6 H14 O12 P2 C([C@@H]1[....
34 4KCT - PYR C3 H4 O3 CC(=O)C(=O....
35 4HYW - FDP C6 H14 O12 P2 C([C@@H]1[....
36 4KCU - MLT C4 H6 O5 C([C@H](C(....
37 4HYV - PEP C3 H5 O6 P C=C(C(=O)O....
38 4KCW - OXL C2 O4 C(=O)(C(=O....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PEP; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 PEP 1 1
2 UVW 0.44 0.709677
Ligand no: 2; Ligand: FBP; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 AFP 1 1
2 FBP 1 1
3 F1X 0.744186 0.954545
4 F6P 0.666667 0.954545
5 TA6 0.666667 0.954545
6 FDP 0.462963 0.954545
7 QIF 0.461538 0.787234
8 OI7 0.448276 0.976744
9 F1P 0.418182 0.847826
10 AHG 0.404255 0.930233
Similar Ligands (3D)
Ligand no: 1; Ligand: PEP; Similar ligands found: 1058
No: Ligand Similarity coefficient
1 GZ3 1.0000
2 R67 1.0000
3 SPV 1.0000
4 GUN 1.0000
5 X6X 1.0000
6 CIT 1.0000
7 0V5 1.0000
8 ASP 1.0000
9 3SL 0.9982
10 PEQ 0.9969
11 PPR 0.9964
12 LLQ 0.9809
13 PGA 0.9769
14 2PG 0.9722
15 PEZ 0.9713
16 FB2 0.9705
17 PAH 0.9685
18 XSP 0.9684
19 OAA 0.9667
20 1GP 0.9647
21 PMB 0.9638
22 SEP 0.9633
23 AL0 0.9609
24 COI 0.9605
25 FBV 0.9604
26 NM2 0.9603
27 NM3 0.9603
28 X1S 0.9600
29 G3P 0.9589
30 DYA 0.9583
31 MLT 0.9580
32 1SA 0.9579
33 OSE 0.9579
34 2RH 0.9561
35 LMR 0.9561
36 FB1 0.9560
37 CIZ 0.9555
38 13P 0.9550
39 IP8 0.9548
40 40E 0.9547
41 3PP 0.9545
42 TEO 0.9544
43 AKG 0.9539
44 IOM 0.9538
45 KVP 0.9528
46 4LR 0.9527
47 CMS 0.9527
48 AAS 0.9523
49 DGL 0.9521
50 DS0 0.9519
51 SAN 0.9515
52 CRN 0.9511
53 CCD 0.9509
54 ASN 0.9508
55 ITN 0.9507
56 DAS 0.9504
57 GP9 0.9503
58 TSU 0.9500
59 HL5 0.9498
60 PGH 0.9498
61 LEU 0.9494
62 CHH 0.9488
63 3LR 0.9486
64 GLN 0.9483
65 GPF 0.9483
66 GPJ 0.9483
67 NXA 0.9482
68 AHB 0.9480
69 FBW 0.9479
70 3PG 0.9478
71 HG3 0.9478
72 FBS 0.9475
73 ACH 0.9474
74 1SH 0.9462
75 1DV 0.9458
76 4J8 0.9451
77 LTL 0.9447
78 HPS 0.9445
79 G3H 0.9443
80 UGC 0.9440
81 G2H 0.9440
82 GUA 0.9439
83 DGN 0.9437
84 ALA ALA 0.9436
85 AMS 0.9432
86 51R 0.9432
87 SVD 0.9431
88 PSE 0.9431
89 QMP 0.9430
90 XCZ 0.9429
91 JYD 0.9415
92 FCR 0.9413
93 EKZ 0.9411
94 SRT 0.9411
95 HPV 0.9409
96 CCE 0.9407
97 8K2 0.9403
98 A09 0.9402
99 HIO 0.9402
100 GLU 0.9394
101 152 0.9392
102 ICF 0.9390
103 DMV 0.9387
104 GVM 0.9386
105 CYX 0.9386
106 2AS 0.9385
107 RTK 0.9373
108 RHU 0.9370
109 8EW 0.9367
110 TLA 0.9365
111 HBU 0.9363
112 ONL 0.9362
113 GG6 0.9360
114 9ON 0.9357
115 FEH 0.9346
116 DAL DAL 0.9344
117 2HG 0.9344
118 2IT 0.9343
119 GGL 0.9343
120 X0V 0.9341
121 OPE 0.9341
122 S2G 0.9340
123 7N0 0.9337
124 8GL 0.9331
125 4FH 0.9322
126 AT3 0.9316
127 PMF 0.9316
128 ZGL 0.9315
129 OEG 0.9315
130 SIN 0.9310
131 ORN 0.9307
132 EDR 0.9305
133 3S5 0.9305
134 URO 0.9303
135 4SX 0.9299
136 SYC 0.9297
137 PLU 0.9296
138 PAF 0.9293
139 SKG 0.9291
140 PCA 0.9287
141 PC 0.9284
142 RNT 0.9283
143 ISZ 0.9278
144 RNS 0.9277
145 MAE 0.9276
146 NLE 0.9275
147 98J 0.9274
148 FUM 0.9269
149 CFI 0.9264
150 P22 0.9263
151 TAR 0.9260
152 1DQ 0.9258
153 B85 0.9254
154 OEM 0.9251
155 OKG 0.9248
156 6JN 0.9247
157 HX2 0.9244
158 SME 0.9244
159 BNS 0.9243
160 K6V 0.9243
161 SYM 0.9241
162 DHI 0.9238
163 HHI 0.9238
164 DQY 0.9236
165 NMG 0.9234
166 RSO 0.9234
167 URQ 0.9233
168 UY7 0.9231
169 2FT 0.9229
170 SD4 0.9229
171 MDN 0.9229
172 GLY ALA 0.9228
173 KBB 0.9224
174 DBX 0.9223
175 A20 0.9221
176 4MV 0.9218
177 YCP 0.9218
178 2PN 0.9217
179 FOC 0.9216
180 QY9 0.9215
181 HDA 0.9215
182 URP 0.9214
183 IFP 0.9214
184 2CO 0.9214
185 LNO 0.9213
186 SPA 0.9211
187 129 0.9211
188 IHG 0.9209
189 I1E 0.9205
190 BAM 0.9205
191 6PC 0.9203
192 BEN 0.9201
193 BEZ 0.9199
194 PBC 0.9199
195 HYP 0.9197
196 ILE 0.9197
197 FCN 0.9195
198 SMN 0.9192
199 PAC 0.9192
200 KPL 0.9191
201 HZP 0.9191
202 OGA 0.9188
203 RMN 0.9187
204 FLA 0.9187
205 TPA 0.9187
206 PG3 0.9186
207 EYK 0.9183
208 NCA 0.9179
209 SS2 0.9177
210 KMH 0.9177
211 4NG 0.9176
212 SS1 0.9174
213 PZI 0.9173
214 TPO 0.9173
215 49F 0.9172
216 K5W 0.9172
217 I4B 0.9169
218 XLS 0.9169
219 0OC 0.9167
220 S0H 0.9167
221 QSC 0.9166
222 MUC 0.9166
223 NIO 0.9163
224 1P3 0.9163
225 DYT 0.9159
226 PHB 0.9159
227 PZA 0.9159
228 PPV 0.9159
229 SC2 0.9157
230 PIS 0.9157
231 MLE 0.9156
232 QDK 0.9155
233 BHO 0.9154
234 PHU 0.9153
235 3HG 0.9152
236 NPO 0.9152
237 URS 0.9150
238 TIU 0.9150
239 PAB 0.9150
240 PRO 0.9149
241 PBZ 0.9147
242 NIZ 0.9144
243 GRO 0.9143
244 KVV 0.9142
245 3OC 0.9141
246 GLY GLY 0.9141
247 MED 0.9141
248 0VT 0.9140
249 M58 0.9140
250 RBL 0.9137
251 VGL 0.9136
252 E4P 0.9134
253 GAB 0.9134
254 UNU 0.9132
255 HIS 0.9131
256 MRZ 0.9131
257 4CS 0.9130
258 HSE 0.9129
259 IZC 0.9129
260 FSG 0.9128
261 53C 0.9127
262 OTR 0.9127
263 POP 0.9127
264 IXW 0.9126
265 5FX 0.9125
266 51F 0.9125
267 OK7 0.9123
268 FBM 0.9123
269 7VD 0.9123
270 LFC 0.9122
271 C21 0.9121
272 THE 0.9121
273 AC0 0.9119
274 9X6 0.9119
275 3MV 0.9119
276 NTN 0.9119
277 PO6 0.9118
278 8GC 0.9118
279 9RW 0.9115
280 MEV 0.9115
281 R9M 0.9114
282 HBD 0.9113
283 1Y6 0.9112
284 GBD 0.9112
285 INO 0.9111
286 C5A 0.9110
287 3V4 0.9110
288 8OZ 0.9109
289 7A8 0.9108
290 SHF 0.9108
291 NBZ 0.9108
292 ODV 0.9107
293 AC6 0.9106
294 UYA 0.9106
295 XYL 0.9105
296 RB5 0.9105
297 RB0 0.9105
298 FK8 0.9101
299 3AB 0.9101
300 GJZ 0.9100
301 SOR 0.9100
302 3BZ 0.9099
303 NSB 0.9099
304 TFB 0.9099
305 TIH 0.9099
306 R9S 0.9098
307 HSO 0.9098
308 LY0 0.9098
309 MET 0.9098
310 2D8 0.9094
311 3NT 0.9094
312 XUL 0.9093
313 OHP 0.9092
314 DAB 0.9092
315 7WG 0.9090
316 ASC 0.9089
317 BE2 0.9089
318 3HB 0.9088
319 M3H 0.9086
320 OVV 0.9085
321 DCO 0.9085
322 MXN 0.9084
323 K34 0.9083
324 ROR 0.9083
325 MPD 0.9083
326 M45 0.9081
327 9X7 0.9080
328 60P 0.9079
329 FBJ 0.9079
330 NMJ 0.9077
331 3FH 0.9076
332 PCT 0.9075
333 SAL 0.9075
334 14J 0.9075
335 M4T 0.9074
336 RAT 0.9074
337 EHM 0.9073
338 NNO 0.9071
339 K7M 0.9069
340 GWM 0.9069
341 LNR 0.9067
342 HY3 0.9066
343 DHB 0.9065
344 TZL 0.9065
345 ZBT 0.9065
346 5HN 0.9065
347 93K 0.9065
348 SAT 0.9064
349 H95 0.9063
350 4NC 0.9063
351 JKE 0.9063
352 WCE 0.9062
353 NVA 0.9060
354 AOS 0.9060
355 449 0.9059
356 6M4 0.9058
357 3U4 0.9057
358 RUJ 0.9056
359 P72 0.9054
360 M6W 0.9053
361 69O 0.9052
362 ISD 0.9051
363 HDH 0.9049
364 273 0.9047
365 HMS 0.9047
366 173 0.9047
367 APG 0.9047
368 4MA 0.9044
369 54D 0.9043
370 FBU 0.9043
371 LYS 0.9042
372 MYJ 0.9042
373 23B 0.9041
374 Z82 0.9041
375 41K 0.9040
376 MTL 0.9040
377 SW7 0.9039
378 B40 0.9039
379 BE7 0.9036
380 9YT 0.9036
381 FQI 0.9036
382 9YL 0.9035
383 JZ7 0.9033
384 4A3 0.9032
385 HGA 0.9032
386 HCS 0.9031
387 BRT 0.9030
388 XX2 0.9030
389 MNN 0.9030
390 FOM 0.9029
391 R2P 0.9028
392 F9P 0.9027
393 IT2 0.9027
394 HBA 0.9027
395 FHB 0.9026
396 CP 0.9026
397 2HO 0.9025
398 9TW 0.9023
399 HYA 0.9023
400 TAG 0.9023
401 826 0.9021
402 TB6 0.9021
403 XBT 0.9020
404 XXG 0.9020
405 7BC 0.9018
406 P9P 0.9017
407 DCL 0.9017
408 9SE 0.9016
409 3HM 0.9015
410 DE5 0.9015
411 PRS 0.9015
412 5XB 0.9015
413 4JC 0.9013
414 TZC 0.9013
415 4SV 0.9012
416 VNJ 0.9012
417 1DJ 0.9011
418 45L 0.9011
419 3HP 0.9011
420 WOT 0.9010
421 K6H 0.9009
422 4JT 0.9009
423 TZE 0.9007
424 3YP 0.9005
425 23J 0.9004
426 I2M 0.9004
427 AC5 0.9002
428 MSE 0.9001
429 THR 0.9001
430 BZ3 0.9001
431 DHS 0.9000
432 MD0 0.9000
433 FP1 0.8999
434 3SK 0.8998
435 FAN 0.8998
436 CXF 0.8997
437 MZT 0.8996
438 ES6 0.8996
439 069 0.8994
440 KMT 0.8993
441 JZ5 0.8992
442 GOJ 0.8992
443 VAH 0.8990
444 T2C 0.8990
445 8EZ 0.8990
446 XX3 0.8990
447 KIV 0.8989
448 QSB 0.8989
449 2AL 0.8988
450 1WD 0.8986
451 IQ0 0.8986
452 3BU 0.8984
453 NCT 0.8982
454 RJY 0.8981
455 FBT 0.8981
456 FA1 0.8980
457 JLZ 0.8979
458 PAE 0.8978
459 CHB 0.8977
460 AHN 0.8977
461 2TQ 0.8977
462 SDD 0.8976
463 OXQ 0.8975
464 AEG 0.8974
465 5OB 0.8972
466 265 0.8971
467 7WV 0.8971
468 2PC 0.8969
469 DPR 0.8969
470 SHA 0.8966
471 RIP 0.8966
472 I38 0.8965
473 174 0.8963
474 IPM 0.8962
475 TP5 0.8962
476 PEA 0.8961
477 IHB 0.8960
478 NK2 0.8958
479 5AC 0.8957
480 M4S 0.8957
481 4P5 0.8956
482 S8V 0.8955
483 4HP 0.8955
484 L99 0.8955
485 HY1 0.8954
486 SKM 0.8954
487 BAE 0.8954
488 ARB 0.8954
489 HCI 0.8953
490 0MK 0.8952
491 XM0 0.8951
492 OAF 0.8951
493 4XR 0.8949
494 SMV 0.8949
495 PIM 0.8948
496 HHH 0.8947
497 GYE 0.8947
498 1AB 0.8947
499 SKJ 0.8946
500 J9T 0.8946
501 KTA 0.8945
502 VAL 0.8944
503 CN0 0.8943
504 BZX 0.8943
505 FUD 0.8941
506 GAG 0.8940
507 SOL 0.8940
508 DPN 0.8939
509 GTQ 0.8939
510 KDG 0.8939
511 PIY 0.8936
512 AG2 0.8936
513 JBN 0.8936
514 PYC 0.8935
515 PEL 0.8934
516 FA0 0.8933
517 PHE 0.8932
518 HF2 0.8931
519 HPA 0.8927
520 7MU 0.8926
521 MAK 0.8926
522 5NU 0.8925
523 F60 0.8923
524 271 0.8923
525 4P0 0.8922
526 R2B 0.8922
527 GLO 0.8921
528 261 0.8919
529 A13 0.8917
530 269 0.8917
531 DHM 0.8915
532 CDV 0.8914
533 1LN 0.8913
534 GTK 0.8912
535 MNM 0.8912
536 92K 0.8911
537 XRG 0.8911
538 HFA 0.8907
539 MEQ 0.8907
540 CXP 0.8906
541 GLL 0.8906
542 14O 0.8905
543 5H1 0.8905
544 DOB 0.8904
545 N4B 0.8903
546 IDM 0.8903
547 9J3 0.8902
548 OVM 0.8902
549 DAV 0.8901
550 B3U 0.8900
551 SNE 0.8900
552 9DG 0.8900
553 6AI 0.8898
554 IP0 0.8897
555 H42 0.8897
556 2K4 0.8896
557 5MI 0.8896
558 BCU 0.8896
559 6OT 0.8895
560 3MB 0.8892
561 54G 0.8890
562 FPY 0.8889
563 ZXD 0.8888
564 Q88 0.8888
565 UFV 0.8887
566 3QM 0.8887
567 5RG 0.8886
568 911 0.8885
569 5MB 0.8884
570 J0Z 0.8884
571 J9Q 0.8884
572 97T 0.8883
573 9TY 0.8883
574 EDG 0.8882
575 T9G 0.8882
576 PSJ 0.8879
577 FOA 0.8878
578 717 0.8878
579 RIB 0.8876
580 5M0 0.8875
581 6NA 0.8875
582 JBE 0.8875
583 5CU 0.8874
584 258 0.8874
585 DHY 0.8873
586 5XC 0.8870
587 Q07 0.8870
588 23W 0.8868
589 5HY 0.8867
590 OW4 0.8867
591 LPK 0.8867
592 MJ2 0.8866
593 BHA 0.8864
594 KOJ 0.8864
595 11S 0.8864
596 2LP 0.8861
597 DII 0.8860
598 HSM 0.8859
599 PRA 0.8856
600 G8M 0.8856
601 PYD 0.8856
602 2FY 0.8856
603 4FA 0.8854
604 LER 0.8854
605 7HP 0.8854
606 X1R 0.8853
607 DHK 0.8851
608 Z6J 0.8851
609 SJ5 0.8851
610 CSS 0.8851
611 4M0 0.8849
612 ABU 0.8847
613 MWP 0.8847
614 YRL 0.8846
615 52C 0.8845
616 3AL 0.8844
617 ES9 0.8844
618 6CS 0.8844
619 Q02 0.8843
620 HTX 0.8842
621 FAC 0.8841
622 4WL 0.8839
623 ASO 0.8839
624 ABV 0.8838
625 SIF 0.8837
626 6M9 0.8836
627 IND 0.8835
628 PKU 0.8834
629 5QY 0.8834
630 IMR 0.8834
631 XYS 0.8834
632 AEF 0.8833
633 JB5 0.8833
634 BHH 0.8832
635 HMU 0.8832
636 LEA 0.8831
637 LDP 0.8830
638 9TZ 0.8830
639 PBE 0.8830
640 JZ4 0.8829
641 FYU 0.8829
642 L3Q 0.8828
643 FUL 0.8828
644 Q03 0.8827
645 N2Z 0.8826
646 PPY 0.8826
647 COU 0.8825
648 H4N 0.8825
649 0HN 0.8824
650 LZ1 0.8824
651 FPK 0.8824
652 NFQ 0.8823
653 TH7 0.8823
654 SOE 0.8823
655 4ZA 0.8822
656 4VP 0.8822
657 HL4 0.8821
658 JAE 0.8820
659 8H8 0.8820
660 ADE 0.8820
661 192 0.8819
662 XYP 0.8819
663 ORO 0.8817
664 MPI 0.8817
665 DOR 0.8817
666 DGJ 0.8816
667 WBU 0.8816
668 IFM 0.8816
669 URF 0.8816
670 BNF 0.8815
671 MRY 0.8815
672 KBZ 0.8813
673 5MK 0.8813
674 IF7 0.8813
675 HBX 0.8813
676 G4D 0.8813
677 1DU 0.8812
678 JZ9 0.8811
679 TYE 0.8810
680 TYL 0.8808
681 03V 0.8807
682 FK1 0.8807
683 SYG 0.8806
684 BZI 0.8805
685 2MH 0.8803
686 F05 0.8802
687 AKB 0.8801
688 TDR 0.8801
689 1PT 0.8801
690 1P7 0.8800
691 DPF 0.8800
692 NF3 0.8800
693 1F1 0.8799
694 ALO 0.8799
695 OCH 0.8798
696 NK1 0.8798
697 2ZM 0.8798
698 AMC 0.8797
699 N8P 0.8797
700 FUF 0.8795
701 ABN 0.8795
702 2AQ 0.8794
703 0R1 0.8793
704 GLA 0.8793
705 RM1 0.8792
706 1LQ 0.8792
707 ABE 0.8790
708 BDF 0.8790
709 DEN 0.8789
710 IPB 0.8788
711 FRU 0.8787
712 JAB 0.8786
713 D1X 0.8786
714 6NT 0.8786
715 0HO 0.8786
716 6NI 0.8786
717 2CK 0.8784
718 MR1 0.8783
719 BMA 0.8783
720 RUU 0.8783
721 AHR 0.8781
722 IT9 0.8780
723 BZF 0.8780
724 BML 0.8780
725 5NI 0.8777
726 3HA 0.8777
727 4FS 0.8776
728 GVH 0.8774
729 R1X 0.8774
730 ES5 0.8773
731 1X4 0.8773
732 10L 0.8773
733 GAF 0.8773
734 AMH 0.8769
735 5DI 0.8769
736 IFL 0.8768
737 GCO 0.8767
738 OVP 0.8767
739 1MC 0.8767
740 4SD 0.8767
741 BP1 0.8766
742 RBJ 0.8764
743 JFJ 0.8764
744 SYN 0.8764
745 5B1 0.8763
746 MCT 0.8763
747 SX1 0.8761
748 F31 0.8761
749 FUB 0.8761
750 2FG 0.8761
751 H76 0.8760
752 AX7 0.8759
753 270 0.8759
754 24B 0.8758
755 4ZE 0.8758
756 J9N 0.8758
757 282 0.8758
758 2AC 0.8757
759 3NY 0.8755
760 MWM 0.8755
761 4JP 0.8754
762 PRZ 0.8754
763 FBA 0.8753
764 DMD 0.8753
765 5WV 0.8753
766 8NY 0.8753
767 MZW 0.8753
768 QUS 0.8751
769 SER 0.8751
770 DFU 0.8750
771 1DW 0.8748
772 6MP 0.8748
773 XAN 0.8748
774 4CH 0.8748
775 4JL 0.8747
776 NOJ 0.8746
777 HH5 0.8746
778 GZL 0.8745
779 PG0 0.8745
780 ABI 0.8745
781 SSN 0.8745
782 3DY 0.8745
783 0RW 0.8744
784 HHA 0.8744
785 APY 0.8744
786 DBH 0.8744
787 HQJ 0.8744
788 2F6 0.8743
789 ZZT 0.8743
790 GLC 0.8742
791 3ID 0.8741
792 M1A 0.8741
793 DTL 0.8741
794 HMH 0.8740
795 EA1 0.8739
796 7WA 0.8739
797 A1U 0.8739
798 BP9 0.8738
799 LDU 0.8737
800 2MP 0.8736
801 4JM 0.8735
802 LRH 0.8735
803 2KT 0.8735
804 E5X 0.8734
805 GAL 0.8734
806 RSF 0.8734
807 CTS 0.8733
808 XYD 0.8733
809 QUZ 0.8732
810 DA4 0.8731
811 2MI 0.8729
812 OMD 0.8729
813 B09 0.8728
814 0CT 0.8728
815 34A 0.8728
816 DHR 0.8727
817 OXC 0.8727
818 9DA 0.8726
819 1SP 0.8725
820 LT2 0.8724
821 ES2 0.8722
822 FPI 0.8721
823 SWA 0.8720
824 I3A 0.8720
825 KYD 0.8719
826 ICP 0.8719
827 XBZ 0.8719
828 FUC 0.8719
829 DSN 0.8719
830 PY7 0.8718
831 F1A 0.8718
832 3DO 0.8717
833 67N 0.8716
834 XIY 0.8716
835 3A9 0.8716
836 NPY 0.8715
837 FCA 0.8715
838 3PF 0.8715
839 BGC 0.8715
840 9EW 0.8714
841 2BG 0.8714
842 2HQ 0.8713
843 ODO 0.8713
844 TTL 0.8713
845 4JU 0.8713
846 34D 0.8711
847 PBA 0.8710
848 XQ0 0.8709
849 ES0 0.8709
850 5MH 0.8709
851 1MR 0.8708
852 3M0 0.8707
853 TH0 0.8706
854 GBN 0.8705
855 ES7 0.8704
856 4CL 0.8703
857 N7P 0.8702
858 9HX 0.8701
859 O7U 0.8701
860 ET2 0.8700
861 FW5 0.8700
862 IPZ 0.8700
863 HC4 0.8700
864 EOU 0.8699
865 MAN 0.8698
866 MAJ 0.8697
867 2HU 0.8697
868 36E 0.8697
869 JZ2 0.8697
870 3C4 0.8697
871 3PY 0.8697
872 PYF 0.8696
873 2DR 0.8696
874 CWM 0.8696
875 CTL 0.8695
876 M44 0.8694
877 TMH 0.8694
878 36R 0.8691
879 VNL 0.8691
880 KKN 0.8689
881 HX3 0.8688
882 1P8 0.8688
883 42J 0.8688
884 4JJ 0.8688
885 FBB 0.8687
886 VGD 0.8687
887 4PN 0.8687
888 2D0 0.8687
889 43M 0.8687
890 2BX 0.8687
891 JF6 0.8686
892 AZA 0.8685
893 DMJ 0.8684
894 PM6 0.8683
895 E7Z 0.8680
896 ES4 0.8679
897 CYS 0.8679
898 RAM 0.8679
899 CLW 0.8678
900 5RN 0.8678
901 32O 0.8677
902 NBE 0.8676
903 FA3 0.8676
904 OHG 0.8676
905 3F0 0.8675
906 YIO 0.8674
907 TM7 0.8674
908 LXC 0.8674
909 PLQ 0.8673
910 GDE 0.8672
911 MS9 0.8672
912 GVG 0.8671
913 MZG 0.8670
914 RUY 0.8669
915 K2T 0.8669
916 ANN 0.8669
917 NSP 0.8667
918 6TZ 0.8666
919 NK 0.8666
920 9RH 0.8665
921 4NM 0.8664
922 HQE 0.8664
923 1M2 0.8663
924 JAW 0.8662
925 PYJ 0.8661
926 JZ3 0.8660
927 SN4 0.8659
928 BTE 0.8659
929 BTM 0.8659
930 IWT 0.8659
931 264 0.8658
932 SVN 0.8658
933 B0D 0.8658
934 MLI 0.8658
935 HDL 0.8657
936 8WO 0.8656
937 4HO 0.8656
938 RM4 0.8656
939 B24 0.8655
940 F9Y 0.8654
941 AW5 0.8653
942 J1Z 0.8647
943 ISN 0.8646
944 86J 0.8645
945 C2B 0.8645
946 BDP 0.8644
947 PNZ 0.8644
948 7W4 0.8643
949 CPZ 0.8642
950 0R0 0.8641
951 F4E 0.8640
952 LGC 0.8640
953 CFP 0.8639
954 HQY 0.8638
955 IVA 0.8638
956 64K 0.8637
957 HT4 0.8633
958 6FZ 0.8632
959 FPN 0.8632
960 AGK 0.8631
961 4BZ 0.8630
962 R8V 0.8628
963 SF9 0.8627
964 ARW 0.8627
965 R20 0.8627
966 ARA 0.8626
967 4Z4 0.8624
968 LCN 0.8623
969 4PW 0.8623
970 280 0.8621
971 GIF 0.8621
972 141 0.8621
973 286 0.8619
974 5SG 0.8619
975 ICO 0.8618
976 AZF 0.8617
977 149 0.8616
978 JBK 0.8612
979 QWN 0.8612
980 3HL 0.8611
981 5IQ 0.8610
982 2CL 0.8609
983 QIC 0.8608
984 MSR 0.8607
985 4YS 0.8606
986 5Q0 0.8606
987 BPN 0.8604
988 1SQ 0.8604
989 TZF 0.8604
990 MLA 0.8603
991 36Y 0.8602
992 4JQ 0.8602
993 AOT 0.8601
994 JPZ 0.8599
995 N5J 0.8598
996 ECE 0.8597
997 Q6T 0.8597
998 24W 0.8596
999 QSH 0.8596
1000 BNL 0.8596
1001 2YU 0.8594
1002 DGY 0.8594
1003 259 0.8594
1004 PA1 0.8594
1005 5QX 0.8594
1006 PAV 0.8593
1007 6F0 0.8592
1008 TNE 0.8592
1009 KBG 0.8588
1010 1WC 0.8588
1011 FCB 0.8586
1012 LSA 0.8584
1013 HX4 0.8583
1014 A2F 0.8582
1015 C2A 0.8582
1016 PH3 0.8580
1017 3PO 0.8580
1018 GCS 0.8579
1019 4YO 0.8579
1020 DX4 0.8578
1021 S76 0.8575
1022 D48 0.8575
1023 AZG 0.8573
1024 QXW 0.8573
1025 PDC 0.8572
1026 3Z8 0.8569
1027 278 0.8568
1028 ADA 0.8565
1029 SNU 0.8562
1030 CGB 0.8561
1031 NDH 0.8560
1032 TAU 0.8559
1033 1WG 0.8557
1034 0JD 0.8556
1035 GTR 0.8554
1036 P2D 0.8553
1037 IPU 0.8553
1038 3XX 0.8552
1039 ALL 0.8547
1040 IGA 0.8546
1041 2ZV 0.8545
1042 R8A 0.8544
1043 JDN 0.8544
1044 M2K 0.8543
1045 2RA 0.8542
1046 COM 0.8539
1047 25W 0.8535
1048 A3B 0.8532
1049 1AL 0.8531
1050 PTO 0.8531
1051 1NP 0.8530
1052 MLM 0.8529
1053 PD2 0.8528
1054 DBB 0.8524
1055 0F9 0.8518
1056 CHT 0.8515
1057 GXY 0.8513
1058 JB8 0.8507
Ligand no: 2; Ligand: FBP; Similar ligands found: 28
No: Ligand Similarity coefficient
1 IR8 0.9392
2 IR9 0.9305
3 SGN 0.9265
4 RI2 0.9131
5 G16 0.9071
6 GAR 0.8941
7 FDQ 0.8871
8 U5P 0.8856
9 UP6 0.8851
10 RUB 0.8839
11 MGF G6P 0.8813
12 BG6 MGF 0.8805
13 D8X 0.8739
14 362 0.8735
15 PDD 0.8731
16 16G 0.8729
17 G6P MGF 0.8710
18 IRN 0.8692
19 6PG 0.8671
20 4UB 0.8665
21 AMZ 0.8640
22 NGS 0.8626
23 C5P 0.8624
24 UMP 0.8616
25 DCM 0.8593
26 9XZ 0.8586
27 C2R 0.8575
28 AIR 0.8546
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 4IP7; Ligand: FBP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 4ip7.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 4IP7; Ligand: FBP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 4ip7.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 3; Query (leader) PDB : 4IP7; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 3) in the query (biounit: 4ip7.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 4; Query (leader) PDB : 4IP7; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 4) in the query (biounit: 4ip7.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 5; Query (leader) PDB : 4IP7; Ligand: FBP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 5) in the query (biounit: 4ip7.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 6; Query (leader) PDB : 4IP7; Ligand: FBP; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 6) in the query (biounit: 4ip7.bio1) has 19 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 7; Query (leader) PDB : 4IP7; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 7) in the query (biounit: 4ip7.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 8; Query (leader) PDB : 4IP7; Ligand: FLC; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 8) in the query (biounit: 4ip7.bio1) has 14 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 9; Query (leader) PDB : 4IP7; Ligand: ADN; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 9) in the query (biounit: 4ip7.bio1) has 3 residues
No: Leader PDB Ligand Sequence Similarity
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