Receptor
PDB id Resolution Class Description Source Keywords
6SZL 1.45 Å NON-ENZYME: OTHER CRYSTAL STRUCTURE OF YTHDC1 WITH FRAGMENT 7 (DHU_DC1_021) HOMO SAPIENS FRAGMENT COMPLEX YTHDC1 EPITRANSCRIPTOMIC RNA BINDING PR
Ref.: SELECTIVELY DISRUPTING M6A-DEPENDENT PROTEIN-RNA INTERACTIONS WITH FRAGMENTS. ACS CHEM.BIOL. V. 15 618 2020
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SO4 B:602;
B:603;
A:602;
A:603;
A:601;
B:601;
 Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
Invalid;
 none;
none;
none;
none;
none;
none;
 submit data
96.063 O4 S [O-]S...
M3E B:604;
 Valid;
 none;
 ic50 > 1000 uM
188.183 C10 H8 N2 O2 c1ccc...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6RT7 1.73 Å NON-ENZYME: OTHER THE YTH DOMAIN OF YTHDC1 PROTEIN IN COMPLEX WITH GM6ACU OLIGONUCLEOTIDE HOMO SAPIENS PROTEIN-RNA INTERACTION EPITRANSCRIPTOMICS RNA BINDING PRO
Ref.: FLEXIBLE BINDING OF M6A READER PROTEIN YTHDC1 TO IT PREFERRED RNA MOTIF. J CHEM THEORY COMPUT V. 15 7004 2019
Members (34)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 6T07 ic50 > 1000 uM M45 C6 H11 N5 c1nc([nH]n....
2 6SZ1 ic50 > 1000 uM M0W C9 H9 N3 CNc1c2cccc....
3 6T0O - M6N C8 H7 N3 O CC1=Nc2cnc....
4 6SZY ic50 > 1000 uM M5N C11 H16 N2 O CC(C)C1=NC....
5 6SYZ ic50 > 1000 uM M1E C7 H7 N3 S CNc1c2c(cc....
6 6RT5 - G 6MZ C n/a n/a
7 6T01 ic50 = 2057 uM M4B C11 H9 N3 O3 CC1=C(C(=N....
8 6SZ2 - M0Q C9 H9 N3 CNc1ccnc2c....
9 6SZN ic50 > 1000 uM YZM C8 H8 N2 O2 c1ccc(cc1)....
10 6T04 ic50 > 1000 uM M3H C9 H10 N2 c1ccc(cc1)....
11 6SZT ic50 = 1926 uM M4Q C11 H13 N3 O2 S CN(Cc1ccsc....
12 6T05 ic50 > 1000 uM M6H C10 H14 N2 c1ccc(cc1)....
13 6T0C Kd = 22 uM M4E C9 H9 N3 O CNC(=O)c1c....
14 6SZ7 ic50 = 1615 uM M1Q C8 H10 N2 O2 C1CCC2=NC(....
15 6T08 ic50 > 1000 uM M5B C7 H7 N3 O2 S2 c1cc(sc1)S....
16 6SZL ic50 > 1000 uM M3E C10 H8 N2 O2 c1ccc(cc1)....
17 6T11 ic50 = 402 uM O2A C10 H10 N2 O CNC(=O)c1c....
18 6T0Z ic50 > 1000 uM M75 C6 H9 N3 O2 S c1c(nc[nH]....
19 6SZX Kd = 58 uM M4K C15 H17 N3 O2 c1ccc(cc1)....
20 6T02 ic50 > 1000 uM M5E C11 H15 N O c1ccc(cc1)....
21 6RT4 - 6MZ C U n/a n/a
22 6T03 ic50 > 1000 uM MZY C3 H4 N2 S C1=CNC(=S)....
23 6RT7 Kd = 3.7 uM G 6MZ C U n/a n/a
24 6T0A ic50 = 2040 uM M58 C6 H8 N2 S c1cc(cnc1)....
25 6SZR ic50 > 1000 uM M3Z C13 H15 N3 O2 CN(Cc1cccc....
26 6T10 ic50 = 348 uM M6Z C9 H8 I N3 O CNC(=O)c1c....
27 6RT6 Kd = 11.1 uM G G 6MZ C n/a n/a
28 6SZ3 - M1H C10 H14 N2 CNc1ccnc2c....
29 6T0X ic50 > 1000 uM M6W C6 H12 N2 O CNC(=O)[C@....
30 6T06 ic50 = 2010 uM M5H C10 H12 N4 c1ccc2c(c1....
31 6SZ8 ic50 > 1000 uM M1Z C8 H11 N3 O2 C1CCN(C1)C....
32 6T12 ic50 = 825 uM M78 C12 H14 N2 O Cc1c([nH]c....
33 6T0D ic50 = 391 uM M4N C11 H11 N3 O CNC(=O)c1c....
34 6T09 - M4T C7 H8 N2 O CC(=O)Nc1c....
70% Homology Family (34)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 6T07 ic50 > 1000 uM M45 C6 H11 N5 c1nc([nH]n....
2 6SZ1 ic50 > 1000 uM M0W C9 H9 N3 CNc1c2cccc....
3 6T0O - M6N C8 H7 N3 O CC1=Nc2cnc....
4 6SZY ic50 > 1000 uM M5N C11 H16 N2 O CC(C)C1=NC....
5 6SYZ ic50 > 1000 uM M1E C7 H7 N3 S CNc1c2c(cc....
6 6RT5 - G 6MZ C n/a n/a
7 6T01 ic50 = 2057 uM M4B C11 H9 N3 O3 CC1=C(C(=N....
8 6SZ2 - M0Q C9 H9 N3 CNc1ccnc2c....
9 6SZN ic50 > 1000 uM YZM C8 H8 N2 O2 c1ccc(cc1)....
10 6T04 ic50 > 1000 uM M3H C9 H10 N2 c1ccc(cc1)....
11 6SZT ic50 = 1926 uM M4Q C11 H13 N3 O2 S CN(Cc1ccsc....
12 6T05 ic50 > 1000 uM M6H C10 H14 N2 c1ccc(cc1)....
13 6T0C Kd = 22 uM M4E C9 H9 N3 O CNC(=O)c1c....
14 6SZ7 ic50 = 1615 uM M1Q C8 H10 N2 O2 C1CCC2=NC(....
15 6T08 ic50 > 1000 uM M5B C7 H7 N3 O2 S2 c1cc(sc1)S....
16 6SZL ic50 > 1000 uM M3E C10 H8 N2 O2 c1ccc(cc1)....
17 6T11 ic50 = 402 uM O2A C10 H10 N2 O CNC(=O)c1c....
18 6T0Z ic50 > 1000 uM M75 C6 H9 N3 O2 S c1c(nc[nH]....
19 6SZX Kd = 58 uM M4K C15 H17 N3 O2 c1ccc(cc1)....
20 6T02 ic50 > 1000 uM M5E C11 H15 N O c1ccc(cc1)....
21 6RT4 - 6MZ C U n/a n/a
22 6T03 ic50 > 1000 uM MZY C3 H4 N2 S C1=CNC(=S)....
23 6RT7 Kd = 3.7 uM G 6MZ C U n/a n/a
24 6T0A ic50 = 2040 uM M58 C6 H8 N2 S c1cc(cnc1)....
25 6SZR ic50 > 1000 uM M3Z C13 H15 N3 O2 CN(Cc1cccc....
26 6T10 ic50 = 348 uM M6Z C9 H8 I N3 O CNC(=O)c1c....
27 6RT6 Kd = 11.1 uM G G 6MZ C n/a n/a
28 6SZ3 - M1H C10 H14 N2 CNc1ccnc2c....
29 6T0X ic50 > 1000 uM M6W C6 H12 N2 O CNC(=O)[C@....
30 6T06 ic50 = 2010 uM M5H C10 H12 N4 c1ccc2c(c1....
31 6SZ8 ic50 > 1000 uM M1Z C8 H11 N3 O2 C1CCN(C1)C....
32 6T12 ic50 = 825 uM M78 C12 H14 N2 O Cc1c([nH]c....
33 6T0D ic50 = 391 uM M4N C11 H11 N3 O CNC(=O)c1c....
34 6T09 - M4T C7 H8 N2 O CC(=O)Nc1c....
50% Homology Family (34)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6T07 ic50 > 1000 uM M45 C6 H11 N5 c1nc([nH]n....
2 6SZ1 ic50 > 1000 uM M0W C9 H9 N3 CNc1c2cccc....
3 6T0O - M6N C8 H7 N3 O CC1=Nc2cnc....
4 6SZY ic50 > 1000 uM M5N C11 H16 N2 O CC(C)C1=NC....
5 6SYZ ic50 > 1000 uM M1E C7 H7 N3 S CNc1c2c(cc....
6 6RT5 - G 6MZ C n/a n/a
7 6T01 ic50 = 2057 uM M4B C11 H9 N3 O3 CC1=C(C(=N....
8 6SZ2 - M0Q C9 H9 N3 CNc1ccnc2c....
9 6SZN ic50 > 1000 uM YZM C8 H8 N2 O2 c1ccc(cc1)....
10 6T04 ic50 > 1000 uM M3H C9 H10 N2 c1ccc(cc1)....
11 6SZT ic50 = 1926 uM M4Q C11 H13 N3 O2 S CN(Cc1ccsc....
12 6T05 ic50 > 1000 uM M6H C10 H14 N2 c1ccc(cc1)....
13 6T0C Kd = 22 uM M4E C9 H9 N3 O CNC(=O)c1c....
14 6SZ7 ic50 = 1615 uM M1Q C8 H10 N2 O2 C1CCC2=NC(....
15 6T08 ic50 > 1000 uM M5B C7 H7 N3 O2 S2 c1cc(sc1)S....
16 6SZL ic50 > 1000 uM M3E C10 H8 N2 O2 c1ccc(cc1)....
17 6T11 ic50 = 402 uM O2A C10 H10 N2 O CNC(=O)c1c....
18 6T0Z ic50 > 1000 uM M75 C6 H9 N3 O2 S c1c(nc[nH]....
19 6SZX Kd = 58 uM M4K C15 H17 N3 O2 c1ccc(cc1)....
20 6T02 ic50 > 1000 uM M5E C11 H15 N O c1ccc(cc1)....
21 6RT4 - 6MZ C U n/a n/a
22 6T03 ic50 > 1000 uM MZY C3 H4 N2 S C1=CNC(=S)....
23 6RT7 Kd = 3.7 uM G 6MZ C U n/a n/a
24 6T0A ic50 = 2040 uM M58 C6 H8 N2 S c1cc(cnc1)....
25 6SZR ic50 > 1000 uM M3Z C13 H15 N3 O2 CN(Cc1cccc....
26 6T10 ic50 = 348 uM M6Z C9 H8 I N3 O CNC(=O)c1c....
27 6RT6 Kd = 11.1 uM G G 6MZ C n/a n/a
28 6SZ3 - M1H C10 H14 N2 CNc1ccnc2c....
29 6T0X ic50 > 1000 uM M6W C6 H12 N2 O CNC(=O)[C@....
30 6T06 ic50 = 2010 uM M5H C10 H12 N4 c1ccc2c(c1....
31 6SZ8 ic50 > 1000 uM M1Z C8 H11 N3 O2 C1CCN(C1)C....
32 6T12 ic50 = 825 uM M78 C12 H14 N2 O Cc1c([nH]c....
33 6T0D ic50 = 391 uM M4N C11 H11 N3 O CNC(=O)c1c....
34 6T09 - M4T C7 H8 N2 O CC(=O)Nc1c....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: M3E; Similar ligands found: 1
No: Ligand ECFP6 Tc MDL keys Tc
1 M3E 1 1
Similar Ligands (3D)
Ligand no: 1; Ligand: M3E; Similar ligands found: 469
No: Ligand Similarity coefficient
1 BZE 1.0000
2 XDK 0.9706
3 LJ3 0.9638
4 B4O 0.9620
5 M1Z 0.9616
6 X11 0.9610
7 BPY 0.9607
8 AY4 0.9571
9 JG8 0.9549
10 6QF 0.9542
11 MXD 0.9528
12 X48 0.9525
13 L22 0.9516
14 BP7 0.9501
15 6TZ 0.9499
16 F2W 0.9494
17 ANC 0.9476
18 977 0.9471
19 MPV 0.9461
20 344 0.9442
21 CH9 0.9441
22 0W1 0.9437
23 B2T 0.9437
24 BNL 0.9409
25 BZJ 0.9403
26 6J9 0.9402
27 BQ5 0.9401
28 MUK 0.9398
29 78Y 0.9358
30 6Q3 0.9352
31 4FF 0.9345
32 2GD 0.9334
33 R2P 0.9323
34 GZ2 0.9322
35 5F8 0.9316
36 JP2 0.9308
37 3Y7 0.9306
38 0BP 0.9302
39 ZME 0.9281
40 5FL 0.9280
41 BP3 0.9279
42 4V2 0.9265
43 D3G 0.9263
44 R20 0.9262
45 X0W 0.9260
46 L5V 0.9257
47 A5H 0.9240
48 0LO 0.9237
49 92G 0.9236
50 GVG 0.9230
51 HQJ 0.9228
52 NCT 0.9225
53 AN3 0.9223
54 RKV 0.9222
55 1Z6 0.9215
56 S60 0.9212
57 N3W 0.9211
58 TT4 0.9208
59 795 0.9194
60 SQ4 0.9193
61 BIK 0.9191
62 7ZL 0.9190
63 BGU 0.9188
64 JR2 0.9186
65 CNI 0.9184
66 LL1 0.9184
67 AX3 0.9176
68 WOE 0.9173
69 EWG 0.9171
70 5P3 0.9169
71 C53 0.9169
72 IWT 0.9169
73 8G6 0.9163
74 DNQ 0.9162
75 ZRK 0.9150
76 MPK 0.9148
77 KTJ 0.9143
78 EN1 0.9141
79 DXK 0.9139
80 ZYR 0.9136
81 P80 0.9135
82 5F5 0.9133
83 HX4 0.9133
84 W8G 0.9132
85 VXX 0.9128
86 A29 0.9125
87 AVA 0.9123
88 PJW 0.9120
89 2D2 0.9119
90 C0H 0.9117
91 RUY 0.9117
92 A9O 0.9116
93 CK2 0.9115
94 BPU 0.9115
95 TZM 0.9113
96 ONR 0.9113
97 FHC 0.9109
98 0SY 0.9108
99 4XF 0.9105
100 NE2 0.9104
101 1A7 0.9102
102 GF4 0.9098
103 7R4 0.9094
104 SQ7 0.9094
105 EXD 0.9094
106 FZM 0.9090
107 JF6 0.9087
108 1IT 0.9085
109 5JT 0.9084
110 9UL 0.9084
111 SOV 0.9079
112 VM1 0.9078
113 3C5 0.9077
114 A9P 0.9073
115 ALE 0.9071
116 K80 0.9070
117 TMG 0.9070
118 Q4G 0.9070
119 P4L 0.9069
120 WVV 0.9069
121 ENO 0.9066
122 MSR 0.9064
123 5TY 0.9064
124 YTX 0.9063
125 HA5 0.9062
126 30G 0.9058
127 50C 0.9051
128 9CA 0.9047
129 JRB 0.9046
130 PPY 0.9040
131 MIL 0.9039
132 4LW 0.9039
133 3QV 0.9036
134 3PF 0.9036
135 6FB 0.9034
136 4G2 0.9033
137 AUV 0.9033
138 AJY 0.9033
139 YZM 0.9027
140 8NX 0.9026
141 0XT 0.9026
142 4F8 0.9025
143 97T 0.9020
144 TI7 0.9019
145 DHC 0.9016
146 4GU 0.9016
147 A1Y 0.9015
148 J9Q 0.9014
149 DPT 0.9013
150 AH9 0.9010
151 3J8 0.9010
152 JTA 0.9010
153 IQQ 0.9009
154 X0U 0.9007
155 CK1 0.9006
156 6J3 0.9005
157 X6P 0.9004
158 2HC 0.9002
159 0NX 0.9001
160 D48 0.8998
161 363 0.8998
162 QBS 0.8994
163 5E4 0.8989
164 2KU 0.8989
165 5QY 0.8986
166 LEL 0.8985
167 9FL 0.8982
168 M5H 0.8980
169 HJH 0.8978
170 AJD 0.8977
171 HRM 0.8977
172 K3Y 0.8973
173 P7Y 0.8972
174 J5I 0.8972
175 HL4 0.8972
176 V2Z 0.8972
177 TZF 0.8968
178 61M 0.8967
179 J9T 0.8966
180 SV4 0.8964
181 ITE 0.8963
182 S1D 0.8963
183 VBC 0.8960
184 L5D 0.8957
185 BBY 0.8955
186 22L 0.8954
187 FQX 0.8954
188 AVX 0.8951
189 JSX 0.8950
190 ESI 0.8949
191 1KP 0.8946
192 THM 0.8945
193 W29 0.8945
194 CPZ 0.8943
195 PIM 0.8940
196 AYS 0.8939
197 3B4 0.8938
198 AOT 0.8934
199 H70 0.8934
200 1WC 0.8932
201 MUR 0.8931
202 ESP 0.8931
203 NE1 0.8926
204 J9N 0.8926
205 G3E 0.8923
206 46P 0.8923
207 QUS 0.8923
208 36Y 0.8922
209 7VP 0.8919
210 EV0 0.8919
211 4MU 0.8919
212 A5E 0.8918
213 25O 0.8918
214 FCD 0.8917
215 9FE 0.8916
216 68A 0.8914
217 SNU 0.8909
218 KF5 0.8909
219 8UY 0.8908
220 PIY 0.8908
221 HNL 0.8906
222 MMJ 0.8906
223 0F9 0.8905
224 4HB 0.8905
225 N2M 0.8904
226 T2D 0.8901
227 F40 0.8901
228 FER 0.8900
229 TWO 0.8899
230 7I2 0.8898
231 069 0.8896
232 SWX 0.8895
233 4LV 0.8892
234 8HH 0.8889
235 15E 0.8889
236 E3X 0.8888
237 F4E 0.8888
238 2FQ 0.8888
239 B2Y 0.8888
240 SE2 0.8887
241 60L 0.8886
242 BZ2 0.8883
243 ID8 0.8882
244 OX2 0.8879
245 1XA 0.8879
246 TLF 0.8879
247 6ZW 0.8875
248 8XL 0.8871
249 DAH 0.8871
250 5AE 0.8870
251 PBQ 0.8867
252 D2G 0.8867
253 AA 0.8866
254 HNH 0.8865
255 428 0.8865
256 SHI 0.8864
257 5B2 0.8860
258 HSX 0.8857
259 7L4 0.8857
260 3D8 0.8853
261 XM5 0.8852
262 GNV 0.8852
263 6PB 0.8851
264 SAF 0.8850
265 EGR 0.8849
266 MOK 0.8849
267 JWS 0.8848
268 MR6 0.8847
269 DCZ 0.8843
270 DNF 0.8843
271 ANF 0.8841
272 SLS 0.8841
273 PCQ 0.8841
274 THU 0.8839
275 1Z8 0.8839
276 TOH 0.8838
277 PUE 0.8838
278 AKD 0.8835
279 CCV 0.8834
280 6HP 0.8833
281 7ME 0.8833
282 KWB 0.8832
283 LNR 0.8830
284 DUR 0.8829
285 6HO 0.8829
286 TR4 0.8828
287 FMQ 0.8827
288 PHE 0.8825
289 55D 0.8822
290 2WU 0.8819
291 PH3 0.8816
292 G14 0.8815
293 AWE 0.8814
294 IL5 0.8814
295 PEY 0.8813
296 2O6 0.8811
297 7O4 0.8811
298 8HC 0.8807
299 C9E 0.8807
300 OCZ 0.8806
301 5E5 0.8804
302 XCG 0.8803
303 C1M 0.8802
304 HIS 0.8801
305 EQW 0.8799
306 6DP 0.8799
307 ZRL 0.8798
308 54X 0.8797
309 1L5 0.8797
310 2GQ 0.8796
311 9ZE 0.8795
312 F16 0.8794
313 3RP 0.8792
314 2LT 0.8792
315 GVY 0.8790
316 52C 0.8790
317 0HN 0.8788
318 THA 0.8785
319 U7E 0.8784
320 6NT 0.8783
321 P9I 0.8783
322 URI 0.8782
323 0N7 0.8779
324 LDC 0.8776
325 1F1 0.8774
326 ROI 0.8772
327 HCI 0.8770
328 II4 0.8770
329 1SF 0.8769
330 UN1 0.8767
331 HNK 0.8765
332 STT 0.8764
333 TCA 0.8762
334 NIY 0.8762
335 FDR 0.8758
336 9PL 0.8757
337 GO8 0.8756
338 ZZA 0.8755
339 HBO 0.8755
340 PRZ 0.8752
341 TRP 0.8752
342 N7I 0.8752
343 S2P 0.8750
344 N8Y 0.8750
345 8W9 0.8750
346 S98 0.8749
347 DIN 0.8747
348 6NZ 0.8746
349 H4B 0.8742
350 WS7 0.8741
351 2ZM 0.8740
352 EZN 0.8739
353 0HO 0.8739
354 5TZ 0.8739
355 APS 0.8732
356 6XI 0.8732
357 56D 0.8728
358 2HU 0.8727
359 PO6 0.8727
360 LTN 0.8725
361 JGB 0.8723
362 8WT 0.8722
363 12T 0.8722
364 ZEA 0.8720
365 GJK 0.8720
366 36E 0.8719
367 S0D 0.8719
368 5RO 0.8714
369 92P 0.8714
370 0K7 0.8714
371 3VQ 0.8714
372 K48 0.8713
373 JFS 0.8713
374 DE3 0.8712
375 XI7 0.8709
376 ERZ 0.8709
377 5NI 0.8708
378 INO 0.8708
379 3NY 0.8707
380 AH6 0.8707
381 TU0 0.8705
382 WLH 0.8701
383 3VW 0.8701
384 O2Y 0.8699
385 GHM 0.8698
386 ODK 0.8697
387 HPT 0.8694
388 HFA 0.8694
389 N9J 0.8693
390 B1J 0.8692
391 C4E 0.8690
392 FBC 0.8690
393 2B4 0.8689
394 549 0.8688
395 XFE 0.8688
396 BGP 0.8687
397 RGK 0.8686
398 OKM 0.8685
399 HHI 0.8683
400 FWD 0.8681
401 7WR 0.8678
402 0FR 0.8676
403 1FL 0.8676
404 47V 0.8676
405 3D1 0.8675
406 NAG 0.8675
407 J6W 0.8675
408 2QC 0.8674
409 LFQ 0.8673
410 XYP XIF 0.8672
411 5AD 0.8672
412 MR4 0.8668
413 FTV 0.8666
414 E0O 0.8662
415 8WZ 0.8661
416 5BT 0.8661
417 6NI 0.8661
418 SOJ 0.8660
419 EAJ 0.8659
420 DDU 0.8654
421 F5C 0.8650
422 7Q1 0.8646
423 QME 0.8646
424 BTM 0.8646
425 IOS 0.8645
426 JAH 0.8644
427 M45 0.8643
428 SSM 0.8642
429 28B 0.8641
430 5GT 0.8640
431 SQV 0.8639
432 U13 0.8635
433 SYR 0.8632
434 JDN 0.8630
435 H4E 0.8630
436 DFL 0.8629
437 DPN 0.8626
438 F18 0.8626
439 CC5 0.8625
440 RP3 0.8624
441 D1G 0.8624
442 ABI 0.8620
443 DHZ 0.8616
444 8D6 0.8613
445 25F 0.8612
446 ABF 0.8611
447 2BG 0.8610
448 NCV 0.8608
449 JB8 0.8604
450 F69 0.8603
451 QKU 0.8599
452 9GP 0.8597
453 878 0.8596
454 NBG 0.8596
455 FYR 0.8593
456 CJZ 0.8593
457 XEV 0.8584
458 CTD 0.8584
459 F4K 0.8583
460 2F6 0.8578
461 HC4 0.8575
462 TAG 0.8573
463 CR1 0.8573
464 C2Y 0.8572
465 AH3 0.8565
466 FC2 0.8552
467 3DT 0.8550
468 U4J 0.8529
469 ASC 0.8519
Similar Binding Sites (Proteins are less than 50% similar to leader) APoc FAQ
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