Receptor
PDB id Resolution Class Description Source Keywords
6IAM 1.51 Å NON-ENZYME: OTHER MODULATING PROTEIN-PROTEIN INTERACTIONS WITH VISIBLE LIGHT P BACKBONE SWITCHES HOMO SAPIENS HISTONE MODIFICATION TRIMETHYLATION AT -prime LYS-4-prime EPIGENETIC TRANSCRIPTIONAL ACTIVATION NSL COMPLEX OSTEOBLASTS DIFFERENTIATION LEUKEMIA TRANSFERASE
Ref.: MODULATING PROTEIN-PROTEIN INTERACTIONS WITH VISIBLE-LIGHT-RESPONSIVE PEPTIDE BACKBONE PHOTOSWIT CHEMBIOCHEM V. 20 1417 2019
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
K A:401;
A:403;
A:402;
 Part of Protein;
Part of Protein;
Part of Protein;
 none;
none;
none;
 submit data
39.098 K [K+]
GLU ALA LYS PRO C:1;
 Valid;
 Atoms found LESS than expected: % Diff = 0.032;
 Ki = 207 nM
428.51 n/a O=C(N...
NA A:404;
A:405;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
22.99 Na [Na+]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6IAM 1.51 Å NON-ENZYME: OTHER MODULATING PROTEIN-PROTEIN INTERACTIONS WITH VISIBLE LIGHT P BACKBONE SWITCHES HOMO SAPIENS HISTONE MODIFICATION TRIMETHYLATION AT -prime LYS-4-prime EPIGENETIC TRANSCRIPTIONAL ACTIVATION NSL COMPLEX OSTEOBLASTS DIFFERENTIATION LEUKEMIA TRANSFERASE
Ref.: MODULATING PROTEIN-PROTEIN INTERACTIONS WITH VISIBLE-LIGHT-RESPONSIVE PEPTIDE BACKBONE PHOTOSWIT CHEMBIOCHEM V. 20 1417 2019
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 6IAM Ki = 207 nM GLU ALA LYS PRO n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 6IAM Ki = 207 nM GLU ALA LYS PRO n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6IAM Ki = 207 nM GLU ALA LYS PRO n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: GLU ALA LYS PRO; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 GLU ALA LYS PRO 1 1
2 SER LEU LEU LYS LYS LEU LEU LEU ALA PRO 0.5 0.813559
3 GLU LYS PRO SER SER SER 0.485149 0.875
4 MET ASP PRO VAL ASP PRO ASN ILE GLU 0.466667 0.857143
5 LYS ALA LYS 0.4625 0.74
6 VAL LYS PRO GLY 0.447917 0.961538
7 ALA PRO PRO PRO ARG PRO PRO LYS PRO 0.424779 0.779661
8 ARG GLU ARG SER PRO THR ARG 0.424528 0.833333
9 ASP LEU THR ARG PRO 0.419643 0.753846
10 GLU LEU PRO LEU VAL LYS ILE 0.416667 0.925926
Similar Ligands (3D)
Ligand no: 1; Ligand: GLU ALA LYS PRO; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6IAM; Ligand: GLU ALA LYS PRO; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6iam.bio1) has 3 residues
No: Leader PDB Ligand Sequence Similarity
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