Receptor
PDB id Resolution Class Description Source Keywords
1L6O 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE XENOPUS DISHEVELLED PDZ DOMAIN XENOPUS LAEVIS DISHEVELLED WNT PATHWAY PDZ MOLECULAR RECOGNITION GENE REGULATION
Ref.: DAPPER, A DISHEVELLED-ASSOCIATED ANTAGONIST OF BETA-CATENIN AND JNK SIGNALING, IS REQUIRED FOR NOTOCHORD FORMATION DEV.CELL V. 2 449 2002
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
SER LEU LYS LEU MET THR THR VAL D:1;
E:1;
F:1;
Valid;
Valid;
Valid;
none;
none;
none;
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893.138 n/a S(CCC...
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1L6O 2.2 Å NON-ENZYME: TRANSCRIPT_TRANSLATE XENOPUS DISHEVELLED PDZ DOMAIN XENOPUS LAEVIS DISHEVELLED WNT PATHWAY PDZ MOLECULAR RECOGNITION GENE REGULATION
Ref.: DAPPER, A DISHEVELLED-ASSOCIATED ANTAGONIST OF BETA-CATENIN AND JNK SIGNALING, IS REQUIRED FOR NOTOCHORD FORMATION DEV.CELL V. 2 449 2002
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 257 families.
1 1L6O - SER LEU LYS LEU MET THR THR VAL n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 222 families.
1 1L6O - SER LEU LYS LEU MET THR THR VAL n/a n/a
50% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 185 families.
1 1L6O - SER LEU LYS LEU MET THR THR VAL n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar ligands found: 81
No: Ligand ECFP6 Tc MDL keys Tc
1 SER LEU LYS LEU MET THR THR VAL 1 1
2 LEU LYS THR LYS LEU LEU 0.604651 0.84
3 LYS THR LYS LEU LEU 0.581395 0.84
4 SER LEU LYS ILE ASP ASN MET ASP 0.564815 0.888889
5 SER LEU LEU LYS LYS LEU LEU ASP 0.563218 0.862745
6 CYS LEU GLY GLY LEU LEU THR MET VAL 0.557692 0.921569
7 LYS LEU VAL GLN LEU LEU THR THR THR 0.552083 0.843137
8 SER LEU LEU LYS LYS LEU LEU LEU ALA 0.547619 0.84
9 MET ABA LEU ARG MET THR ALA VAL MET 0.541284 0.793103
10 SER LEU LEU MET TRP ILE THR GLN VAL 0.540984 0.746032
11 PHE GLU ALA LYS LYS LEU VAL 0.528736 0.74
12 MET CYS LEU ARG MET THR ALA VAL MET 0.526786 0.824561
13 ASN ARG LEU MET LEU THR GLY 0.514286 0.810345
14 LEU THR THR LYS LEU THR ASN THR ASN ILE 0.504951 0.796296
15 GLU ALA THR GLN LEU MET ASN 0.495238 0.862745
16 LYS SER LEU LEU GLN GLN LEU LEU THR GLU 0.495146 0.865385
17 ARG LEU GLN ARG ARG ARG GLU THR GLN VAL 0.485981 0.741379
18 SER LEU LEU MET TRP ILE THR GLN LEU 0.483871 0.746032
19 MET CYS LEU ARG NLE THR ALA VAL MET 0.483051 0.810345
20 SER LEU LYS ILE ASP ASN LEU ASP 0.481481 0.814815
21 THR LYS CYS VAL VAL MET 0.479592 0.979592
22 SER LEU LEU MET TRP ILE THR GLN SER 0.47619 0.746032
23 LYS MET LYS 0.47619 0.78
24 HIS LYS LEU VAL GLN LEU LEU THR THR THR 0.473684 0.693548
25 SER LEU LEU MET TRP ILE THR GLN ALA 0.472441 0.746032
26 ACE CSO ARG ALA THR LYS MET LEU 0.466102 0.738462
27 ACE VAL LYS GLU SER LEU VAL 0.465347 0.86
28 SER LEU LEU MET TRP ILE THR GLN CYS 0.465116 0.746032
29 SER GLN LEU LYS ASN ASN ALA LYS GLU ILE 0.464286 0.8
30 ASN LEU VAL PRO MET VAL ALA THR VAL 0.463415 0.734375
31 SER ASP LYS ILE ASP ASN LEU ASP 0.458716 0.814815
32 SER LEU ALA ASN THR VAL ALA THR LEU 0.456311 0.769231
33 GLU LEU ARG ARG LYS MET MET TYR MET 0.452991 0.703125
34 GLU LEU LYS ARG LYS MET ILE TYR MET 0.452381 0.676923
35 ALA LEU LYS ILE ASP ASN MET ASP 0.451327 0.814815
36 ASP THR GLU MET GLU GLU VAL ASP 0.45098 0.882353
37 ARG ARG ARG TRP ARG ARG LEU THR VAL 0.45 0.632353
38 LYS LEU LYS 0.445783 0.74
39 LYS ALA VAL TYR ASN LEU ALA THR MET 0.444444 0.810345
40 ARG ARG ALA THR LYS MET NH2 0.444444 0.807018
41 LYS MET ASN THR GLN PHE THR ALA VAL 0.443548 0.839286
42 SER LEU LYS ILE ASP ASN GLU ASP 0.443478 0.814815
43 HIS GLU GLU LEU ALA LYS LEU 0.43617 0.74
44 SER ARG MET GLU GLU VAL ASP 0.432692 0.92
45 SER LEU TYR LEU THR VAL ALA THR LEU 0.432432 0.727273
46 GLN ARG ALA THR LYS MET NH2 0.432432 0.775862
47 LYS CYS VAL VAL MET 0.431579 0.877551
48 GLY LEU MET TRP LEU SER TYR PHE VAL 0.428571 0.707692
49 ALA SER ASN GLU ASN MET GLU THR MET 0.428571 0.867925
50 SER GLU LEU GLU ILE LYS ARG TYR 0.427419 0.676923
51 ASN LEU VAL PRW MET VAL ALA THR VAL 0.427419 0.849057
52 CYS THR GLU LEU LYS LEU SER ASP TYR 0.427419 0.821429
53 GLY THR LEU SER ASN ARG ALA SER LYS LEU 0.425532 0.877551
54 SER ARG LYS ILE ASP ASN LEU ASP 0.425 0.721311
55 THR LYS ASN TYR LYS GLN THR SER VAL 0.425 0.745763
56 LEU PRO PHE GLU LYS SER THR VAL MET 0.42446 0.753846
57 SER ALA LYS ILE ASP ASN LEU ASP 0.422414 0.814815
58 GLU LEU ASN ARG LYS MET ILE TYR MET 0.422222 0.69697
59 ALA PRO ALA LEU ARG VAL VAL LYS 0.421569 0.666667
60 ALA MET ALA PRO ARG THR LEU LEU LEU 0.420635 0.671429
61 LYS THR LYS 0.418605 0.78
62 PHE LEU SER THR LYS 0.416667 0.846154
63 THR SER ARG HIS LYS ALY LEU MET ALA 0.416667 0.731343
64 ALA ILE PHE GLN SER SER MET THR LYS 0.416 0.857143
65 SER LEU ASN TYR ILE ILE LYS VAL LYS GLU 0.415385 0.75
66 ALA SER ASN GLU ASP MET GLU THR MET 0.412844 0.867925
67 GLU LEU ALA GLY ILE GLY ILE LEU THR VAL 0.412281 0.788462
68 ASN SER THR LEU GLN 0.41 0.788462
69 ILE LEU MET GLU HIS ILE HIS LYS LEU 0.409449 0.650794
70 LEU ALA GLY ILE GLY ILE LEU THR VAL 0.409091 0.769231
71 THR LYS CYS VAL PHE MET 0.408696 0.923077
72 CYS THR GLU LEU LYS LEU ASN ASP TYR 0.408 0.775862
73 GLU LEU ALA ALA ILE GLY ILE LEU THR VAL 0.405172 0.803922
74 LYS ALA LEU TYR ASN PHE ALA THR MET 0.40458 0.783333
75 LYS GLN THR SER VAL 0.404255 0.803922
76 ALA ARG LYS LEU ASP 0.40404 0.672414
77 SER LEU PHE ASN THR VAL ALA THR LEU 0.403361 0.727273
78 ASN LEU VAL PRO MET VAL ALA VAL VAL 0.403226 0.65625
79 ALA THR LYS ILE ASP ASN LEU ASP 0.4 0.796296
80 LYS PRO VAL LEU ARG THR ALA 0.4 0.623188
81 LYS LYS LYS ALA 0.4 0.68
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1L6O; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar sites found: 45
This union binding pocket(no: 1) in the query (biounit: 1l6o.bio1) has 19 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 5CHR 4NC 0.002347 0.45228 None
2 5V4R MGT 0.01105 0.43328 None
3 5IUC SIA GAL A2G 0.004803 0.42793 None
4 3QX9 ATP 0.006847 0.42527 None
5 4G0P U5P 0.008043 0.42414 None
6 3UEC ALA ARG TPO LYS 0.01111 0.42162 None
7 3BFF FPM 0.003216 0.40969 None
8 4TUZ 36J 0.008591 0.40692 None
9 2BVE PH5 0.017 0.40265 None
10 1GPM AMP 0.008263 0.42164 4.21053
11 3E9I XAH 0.01825 0.40189 4.21053
12 4RHS SIA SIA GAL 0.00353 0.43899 4.91803
13 2F5Z FAD 0.0307 0.4051 5.26316
14 1HFU NAG NDG 0.01083 0.40336 5.26316
15 3KRU FMN 0.02255 0.40108 5.26316
16 3I7V B4P 0.0007421 0.43873 6.31579
17 4Z3E GAL NGA GLA BGC GAL 0.01157 0.41722 6.31579
18 4MRP GSH 0.01736 0.41495 6.31579
19 2Z9I GLY ALA THR VAL 0.00002092 0.55713 7.36842
20 3SJK LYS PRO VAL LEU ARG THR ALA 0.001553 0.46467 7.36842
21 1DCP HBI 0.005864 0.43069 7.36842
22 3KYQ DPV 0.00667 0.42584 7.36842
23 2Q2V NAD 0.02073 0.40395 7.36842
24 2JLD ALA GLY GLY ALA ALA ALA ALA ALA 0.004475 0.43851 8.42105
25 4FWE FAD 0.03446 0.40259 8.42105
26 2OBD PCW 0.01278 0.41046 9.47368
27 2DYR PGV 0.02314 0.40478 9.47368
28 1VPD TLA 0.02377 0.40385 9.47368
29 2Q8H TF4 0.009966 0.42109 10.5263
30 1X8X TYR 0.007597 0.41365 10.5263
31 3LAD FAD 0.01883 0.41478 11.5789
32 3R9V DXC 0.00883 0.43335 13.6842
33 4N14 WR7 0.005778 0.43049 13.6842
34 3S6X SIA GAL BGC 0.01001 0.42504 13.6842
35 1TDF NAP 0.03323 0.41912 13.6842
36 4ORM FMN 0.04695 0.40738 15.7895
37 4ORM 2V6 0.04695 0.40738 15.7895
38 4ORM ORO 0.04695 0.40738 15.7895
39 1H3F TYE 0.006757 0.42703 16.8421
40 5UC9 MYR 0.004432 0.43851 17.8947
41 3O5N BR0 0.000006466 0.41715 19.6429
42 5OCA 9QZ 0.01322 0.42449 21.0526
43 3BJK CIT 0.01182 0.4145 25.2632
44 4WYU SER TRP PHE GLN THR ASP LEU 0.001186 0.4374 37.8947
45 1MFG GLU TYR LEU GLY LEU ASP VAL PRO VAL 0.001719 0.43472 40
Pocket No.: 2; Query (leader) PDB : 1L6O; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar sites found: 18
This union binding pocket(no: 2) in the query (biounit: 1l6o.bio1) has 21 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 4UYW H1S 0.001521 0.45073 None
2 1XZ3 ICF 0.03078 0.41546 None
3 4B1X LAB 0.01807 0.40345 None
4 2XMY CDK 0.04325 0.40313 None
5 5U98 1KX 0.01719 0.40769 4.21053
6 4C2X NHW 0.01377 0.41223 5.26316
7 2HBL AMP 0.01803 0.41075 6.31579
8 2NZ5 226 0.001543 0.4646 7.36842
9 5AZC PGT 0.04371 0.41034 7.36842
10 3B6C SDN 0.02058 0.40487 7.36842
11 3QDW NDG 0.03795 0.40057 8.42105
12 3QDY CBS 0.03747 0.4005 8.42105
13 5VRH OLB 0.006834 0.43325 11.5789
14 1XVB 3BR 0.01379 0.4051 12.6316
15 4CVN ADP 0.02296 0.40244 12.6316
16 2Z8L NAG FUC SIA GAL 0.02835 0.40302 14.7368
17 4C2C ALA ALA ALA 0.002814 0.45703 18.9474
18 4DFU QUE 0.01508 0.40736 23.1579
Pocket No.: 3; Query (leader) PDB : 1L6O; Ligand: SER LEU LYS LEU MET THR THR VAL; Similar sites found: 19
This union binding pocket(no: 3) in the query (biounit: 1l6o.bio1) has 26 residues
No: Leader PDB Ligand P-value (APoc) PS_Score (APoc) Sequence Similarity
1 3KU0 ADE 0.03842 0.40573 None
2 3L1N PLM 0.01154 0.42601 2.10526
3 2OFE NAG 0.02621 0.4116 4.21053
4 4Z2S NAG 0.03686 0.40446 4.21053
5 4Z2S NDG 0.03686 0.40446 4.21053
6 2OFD NGA 0.03313 0.40435 4.21053
7 4XDZ 40E 0.02854 0.41282 5.26316
8 5E4R 40E 0.02887 0.41275 5.26316
9 3ZPG 5GP 0.02437 0.41625 6.31579
10 1K1Y MAL 0.02241 0.41496 6.31579
11 2VWA PTY 0.02755 0.40654 6.31579
12 2B6N ALA PRO THR 0.01368 0.4096 7.36842
13 3IVV ASP GLU VAL THR SER THR THR SER SER SER 0.02699 0.40667 8.42105
14 2XG5 EC2 0.04537 0.40258 8.42105
15 2XG5 EC5 0.04537 0.40258 8.42105
16 5IJJ I6P 0.03255 0.40374 9.47368
17 3HO6 IHP 0.02898 0.40504 10.5263
18 3P48 DUP 0.01304 0.41055 15.7895
19 1NC4 DOF 0.0242 0.41259 20
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