Receptor
PDB id Resolution Class Description Source Keywords
2HXT 1.7 Å EC: 4.-.-.- CRYSTAL STRUCTURE OF L-FUCONATE DEHYDRATASE FROM XANTHOMONAS CAMPESTRIS LIGANDED WITH MG++ AND D-ERYTHRONOHYDROXAMATE XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS L-FUCONATE DEHYDRATASE ENOLASE SUPERFAMILY D-ERYTHROMOHYDRUNKNOWN FUNCTION
Ref.: EVOLUTION OF ENZYMATIC ACTIVITIES IN THE ENOLASE SUPERFAMILY: L-FUCONATE DEHYDRATASE FROM XANTHOMONA CAMPESTRIS. BIOCHEMISTRY V. 45 14582 2006
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
EHM A:501;
 Valid;
 none;
 submit data
151.118 C4 H9 N O5 C([C@...
MG A:601;
 Part of Protein;
 none;
 submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2HXT 1.7 Å EC: 4.-.-.- CRYSTAL STRUCTURE OF L-FUCONATE DEHYDRATASE FROM XANTHOMONAS CAMPESTRIS LIGANDED WITH MG++ AND D-ERYTHRONOHYDROXAMATE XANTHOMONAS CAMPESTRIS PV. CAMPESTRIS L-FUCONATE DEHYDRATASE ENOLASE SUPERFAMILY D-ERYTHROMOHYDRUNKNOWN FUNCTION
Ref.: EVOLUTION OF ENZYMATIC ACTIVITIES IN THE ENOLASE SUPERFAMILY: L-FUCONATE DEHYDRATASE FROM XANTHOMONA CAMPESTRIS. BIOCHEMISTRY V. 45 14582 2006
Members (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 62 families.
1 2HXT - EHM C4 H9 N O5 C([C@H]([C....
2 2HXU - LFC C6 H12 O6 C[C@@H]([C....
70% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 59 families.
1 2HXT - EHM C4 H9 N O5 C([C@H]([C....
2 2HXU - LFC C6 H12 O6 C[C@@H]([C....
50% Homology Family (2)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 47 families.
1 2HXT - EHM C4 H9 N O5 C([C@H]([C....
2 2HXU - LFC C6 H12 O6 C[C@@H]([C....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: EHM; Similar ligands found: 2
No: Ligand ECFP6 Tc MDL keys Tc
1 EHM 1 1
2 RES 0.447368 0.765957
Similar Ligands (3D)
Ligand no: 1; Ligand: EHM; Similar ligands found: 604
No: Ligand Similarity coefficient
1 RBL 0.9830
2 5FX 0.9818
3 XUL 0.9810
4 RB5 0.9684
5 XYL 0.9622
6 RB0 0.9622
7 XLS 0.9576
8 ROR 0.9559
9 4FA 0.9548
10 FOC 0.9548
11 ILE 0.9529
12 QDK 0.9524
13 XRG 0.9511
14 PZM 0.9478
15 HBA 0.9472
16 GIF 0.9469
17 NPO 0.9467
18 ISZ 0.9431
19 PHB 0.9427
20 4JL 0.9420
21 ARW 0.9399
22 PAB 0.9395
23 RNT 0.9394
24 MAE 0.9389
25 UGC 0.9385
26 AHR 0.9384
27 AGK 0.9379
28 AEF 0.9373
29 RNS 0.9372
30 4VP 0.9371
31 PBZ 0.9370
32 HYA 0.9364
33 OAA 0.9364
34 C2B 0.9358
35 F9P 0.9355
36 FBM 0.9353
37 CFI 0.9352
38 HIO 0.9346
39 NMG 0.9343
40 GP9 0.9340
41 SRT 0.9339
42 DGJ 0.9335
43 BHO 0.9329
44 3DM 0.9326
45 NIZ 0.9319
46 H95 0.9311
47 PAF 0.9310
48 M6W 0.9308
49 ITN 0.9307
50 AC6 0.9306
51 FYU 0.9305
52 CRN 0.9302
53 VAL 0.9298
54 GLY GLY 0.9296
55 KOJ 0.9291
56 H76 0.9290
57 NSP 0.9289
58 ASN 0.9288
59 HSO 0.9286
60 9X7 0.9285
61 MD0 0.9284
62 VAH 0.9281
63 ASP 0.9279
64 BZX 0.9279
65 TZE 0.9277
66 FBA 0.9276
67 TH7 0.9275
68 RUU 0.9268
69 HMH 0.9268
70 KIV 0.9267
71 IXW 0.9266
72 51F 0.9262
73 OKG 0.9258
74 FBJ 0.9258
75 JZ3 0.9256
76 FA0 0.9254
77 JZ4 0.9251
78 HIS 0.9249
79 SIN 0.9245
80 0R0 0.9244
81 MXN 0.9242
82 PCA 0.9242
83 HBD 0.9241
84 KPL 0.9240
85 YRL 0.9236
86 AKG 0.9236
87 23W 0.9235
88 G3P 0.9233
89 RIP 0.9232
90 MNM 0.9226
91 MUC 0.9225
92 9J3 0.9225
93 IOM 0.9223
94 GLN 0.9221
95 NOJ 0.9221
96 4XR 0.9220
97 AL0 0.9220
98 DMV 0.9219
99 URP 0.9219
100 TAR 0.9218
101 MEQ 0.9217
102 R2B 0.9216
103 IFL 0.9216
104 13P 0.9214
105 SD4 0.9214
106 Z6J 0.9213
107 SKG 0.9211
108 THE 0.9211
109 XM0 0.9207
110 LNO 0.9205
111 LDU 0.9204
112 ZZT 0.9201
113 5CU 0.9200
114 8H8 0.9198
115 HDH 0.9198
116 G4D 0.9194
117 PAH 0.9192
118 DFU 0.9192
119 GLA 0.9192
120 FLA 0.9191
121 HMU 0.9191
122 3U4 0.9190
123 LRH 0.9189
124 LMR 0.9187
125 DOB 0.9185
126 2LP 0.9184
127 AKB 0.9184
128 2AS 0.9183
129 MLT 0.9182
130 ZBT 0.9182
131 BAM 0.9180
132 BPN 0.9179
133 MTL 0.9179
134 1GP 0.9178
135 I1E 0.9178
136 32O 0.9177
137 5NU 0.9176
138 SAL 0.9173
139 4MV 0.9172
140 HSE 0.9172
141 BEN 0.9172
142 R1X 0.9171
143 PSJ 0.9171
144 261 0.9170
145 286 0.9170
146 54D 0.9169
147 BE2 0.9169
148 THR 0.9168
149 173 0.9167
150 FUM 0.9167
151 BEZ 0.9165
152 RIB 0.9165
153 CMS 0.9164
154 NXA 0.9164
155 69O 0.9164
156 MNN 0.9164
157 NIO 0.9164
158 FCR 0.9164
159 TLA 0.9162
160 717 0.9161
161 DAS 0.9161
162 MRY 0.9161
163 ES6 0.9160
164 I2M 0.9159
165 GAL 0.9159
166 JZ7 0.9155
167 HDA 0.9154
168 NK 0.9153
169 1DJ 0.9152
170 FPY 0.9150
171 8EW 0.9150
172 GLL 0.9149
173 98J 0.9149
174 EDG 0.9146
175 IF7 0.9143
176 UY7 0.9142
177 4M0 0.9142
178 FEH 0.9141
179 GLU 0.9137
180 PGH 0.9137
181 2XX 0.9136
182 SNE 0.9132
183 6PC 0.9132
184 LFC 0.9131
185 XBT 0.9131
186 PZI 0.9131
187 40E 0.9130
188 AOS 0.9128
189 VKC 0.9128
190 HYP 0.9127
191 BHA 0.9127
192 TYL 0.9127
193 4NC 0.9126
194 FQI 0.9122
195 PZA 0.9122
196 2IT 0.9120
197 GGL 0.9120
198 BSX 0.9117
199 MAK 0.9114
200 G2F 0.9114
201 HX2 0.9112
202 FUL 0.9112
203 SDD 0.9109
204 KMH 0.9109
205 OEM 0.9107
206 ASC 0.9107
207 CYX 0.9105
208 X1S 0.9104
209 DHB 0.9103
210 PGA 0.9102
211 MR1 0.9102
212 PBC 0.9099
213 PRY 0.9096
214 7BC 0.9096
215 RMN 0.9094
216 OTR 0.9093
217 MFU 0.9091
218 E5X 0.9089
219 FUD 0.9087
220 DAB 0.9087
221 4JU 0.9085
222 3V4 0.9083
223 FPI 0.9083
224 TAG 0.9082
225 PKU 0.9082
226 9ON 0.9081
227 R9S 0.9081
228 PSV 0.9078
229 GLY CYS 0.9077
230 PEP 0.9073
231 VNJ 0.9070
232 DXX 0.9068
233 9YL 0.9066
234 COI 0.9066
235 3XX 0.9065
236 4CS 0.9065
237 HHA 0.9063
238 JYD 0.9061
239 TEO 0.9060
240 CXF 0.9060
241 IZC 0.9059
242 CIZ 0.9055
243 3BU 0.9053
244 DTU 0.9053
245 LEU 0.9053
246 24B 0.9051
247 BML 0.9050
248 1P3 0.9050
249 RHU 0.9049
250 4SD 0.9048
251 NOY 0.9048
252 HTX 0.9045
253 AC5 0.9044
254 CEE 0.9043
255 5AC 0.9043
256 3LR 0.9042
257 2CO 0.9040
258 ONL 0.9039
259 JKE 0.9039
260 AMC 0.9038
261 RBJ 0.9037
262 ICF 0.9036
263 MZW 0.9035
264 MLA 0.9034
265 2MH 0.9034
266 AFR 0.9033
267 FUF 0.9033
268 MRZ 0.9032
269 JZ5 0.9031
270 SHA 0.9031
271 ALO 0.9030
272 SOR 0.9026
273 IFM 0.9025
274 5HY 0.9023
275 8EZ 0.9023
276 HCS 0.9023
277 BP9 0.9020
278 HZP 0.9020
279 LER 0.9019
280 T9G 0.9019
281 K34 0.9019
282 NLP 0.9018
283 IMR 0.9018
284 TFB 0.9017
285 DHR 0.9016
286 KMT 0.9016
287 3PP 0.9015
288 QSC 0.9015
289 ABN 0.9014
290 ORN 0.9013
291 DGL 0.9013
292 SYN 0.9012
293 NVA 0.9011
294 1SH 0.9011
295 AHB 0.9009
296 DPF 0.9009
297 3SK 0.9008
298 SPA 0.9008
299 M58 0.9007
300 6M4 0.9006
301 TPA 0.9005
302 1AB 0.9004
303 GLO 0.9003
304 1LN 0.9000
305 K6V 0.9000
306 GUA 0.9000
307 1SA 0.8998
308 3SL 0.8997
309 192 0.8996
310 RSO 0.8995
311 TZL 0.8992
312 GBD 0.8991
313 APY 0.8988
314 KP6 0.8988
315 RAT 0.8988
316 6JN 0.8985
317 SMV 0.8985
318 4HP 0.8984
319 FP1 0.8984
320 PRO 0.8984
321 3OC 0.8981
322 FSG 0.8981
323 G3H 0.8979
324 OHG 0.8978
325 3HA 0.8978
326 PEA 0.8977
327 YCP 0.8977
328 ASO 0.8976
329 2RH 0.8975
330 FUB 0.8975
331 PYJ 0.8974
332 PMF 0.8974
333 GAG 0.8973
334 PEL 0.8973
335 DBH 0.8972
336 AMH 0.8965
337 1MR 0.8965
338 BCU 0.8963
339 H8N 0.8962
340 P2D 0.8961
341 AG2 0.8961
342 B24 0.8961
343 LDP 0.8961
344 7WG 0.8959
345 7MU 0.8959
346 271 0.8958
347 2FT 0.8954
348 DAL DAL 0.8953
349 NLE 0.8953
350 MEV 0.8953
351 IP0 0.8951
352 PAC 0.8950
353 4SV 0.8948
354 60P 0.8947
355 GJZ 0.8946
356 MLI 0.8942
357 PBA 0.8942
358 9X6 0.8942
359 IPB 0.8941
360 7N0 0.8940
361 OHP 0.8940
362 HY1 0.8939
363 BHH 0.8938
364 2PC 0.8938
365 LPK 0.8937
366 2DR 0.8937
367 6NA 0.8935
368 QY9 0.8935
369 HY3 0.8933
370 HSM 0.8933
371 7VD 0.8932
372 S2G 0.8931
373 BDP 0.8929
374 3F0 0.8928
375 SS1 0.8926
376 DYA 0.8926
377 GRO 0.8926
378 SOL 0.8926
379 MED 0.8924
380 GLY ALA 0.8924
381 RUJ 0.8923
382 SS2 0.8923
383 UYA 0.8920
384 BNS 0.8919
385 TIU 0.8916
386 JZ1 0.8915
387 5DI 0.8914
388 C5A 0.8913
389 B53 0.8906
390 MET 0.8906
391 7A8 0.8904
392 2FY 0.8904
393 92K 0.8904
394 OXQ 0.8902
395 NCT 0.8902
396 I4B 0.8901
397 BNF 0.8901
398 PG3 0.8898
399 IT9 0.8895
400 PPR 0.8895
401 2AL 0.8895
402 34V 0.8894
403 S24 0.8892
404 DTL 0.8891
405 AZF 0.8891
406 CYS 0.8890
407 2CL 0.8888
408 9CL 0.8888
409 23B 0.8887
410 R9M 0.8887
411 GG6 0.8887
412 ACH 0.8886
413 BDF 0.8886
414 TPO 0.8885
415 1DU 0.8884
416 URQ 0.8883
417 Q07 0.8883
418 1WD 0.8883
419 PAE 0.8881
420 DHS 0.8879
421 41K 0.8878
422 SME 0.8878
423 NEQ 0.8876
424 3HG 0.8875
425 WTZ 0.8874
426 LLH 0.8874
427 IT2 0.8872
428 5WZ 0.8866
429 42J 0.8864
430 JBN 0.8864
431 4VY 0.8862
432 GZL 0.8862
433 PRS 0.8860
434 0V5 0.8856
435 MS9 0.8856
436 GPF 0.8856
437 3PG 0.8856
438 SPV 0.8855
439 AC0 0.8855
440 6LW 0.8854
441 IHG 0.8853
442 SMN 0.8852
443 TNE 0.8852
444 DHI 0.8850
445 2KT 0.8847
446 SEP 0.8844
447 4JM 0.8843
448 DGY 0.8843
449 PTO 0.8843
450 GZQ 0.8839
451 49F 0.8839
452 QFH 0.8839
453 DIG 0.8836
454 GXY 0.8835
455 8OZ 0.8834
456 OXZ 0.8832
457 SJ5 0.8832
458 GYE 0.8831
459 SKJ 0.8831
460 OGA 0.8831
461 23J 0.8830
462 SC2 0.8830
463 280 0.8830
464 9TY 0.8829
465 3S5 0.8828
466 DMJ 0.8826
467 ALA ALA 0.8825
468 CUW 0.8824
469 7WV 0.8823
470 PHE 0.8823
471 AAE 0.8820
472 1SP 0.8819
473 2HG 0.8818
474 KDG 0.8817
475 0OC 0.8815
476 9SE 0.8813
477 HHH 0.8810
478 FA1 0.8810
479 CSS 0.8809
480 9RW 0.8807
481 069 0.8806
482 DEE 0.8805
483 IQ0 0.8805
484 LYL 0.8804
485 2A9 0.8803
486 449 0.8802
487 5XB 0.8802
488 NBE 0.8801
489 FOM 0.8799
490 6FZ 0.8795
491 E1P 0.8795
492 PBE 0.8794
493 AEG 0.8794
494 DSN 0.8793
495 MAH 0.8792
496 PY7 0.8791
497 3YP 0.8791
498 ICB 0.8791
499 DBB 0.8789
500 GRE 0.8787
501 T2C 0.8786
502 APG 0.8783
503 PG0 0.8780
504 A09 0.8775
505 258 0.8774
506 PAV 0.8774
507 DYT 0.8772
508 L14 0.8769
509 CS2 0.8766
510 RJY 0.8765
511 ODO 0.8765
512 HIU 0.8765
513 GZ3 0.8764
514 152 0.8763
515 KYD 0.8761
516 CCB 0.8760
517 268 0.8758
518 FW5 0.8756
519 K7M 0.8755
520 PPV 0.8755
521 VOH 0.8751
522 PLU 0.8751
523 NYL 0.8749
524 OPE 0.8748
525 5XA 0.8747
526 03W 0.8744
527 6F0 0.8743
528 HL5 0.8742
529 278 0.8740
530 DTT 0.8738
531 ABU 0.8737
532 KDF 0.8736
533 DGN 0.8734
534 DVQ 0.8732
535 PRZ 0.8732
536 GOJ 0.8729
537 DPJ 0.8729
538 MLE 0.8726
539 15N 0.8724
540 GCO 0.8722
541 3C4 0.8720
542 3DO 0.8718
543 N4B 0.8717
544 LNR 0.8715
545 PEQ 0.8712
546 DCY 0.8711
547 6M1 0.8710
548 SVJ 0.8708
549 TSS 0.8707
550 PRA 0.8705
551 BUB 0.8702
552 0LH 0.8702
553 QMP 0.8701
554 FIX 0.8695
555 IPU 0.8690
556 PO6 0.8689
557 3HR 0.8689
558 HHI 0.8688
559 2BX 0.8688
560 MSE 0.8688
561 269 0.8686
562 A3M 0.8684
563 CIT 0.8682
564 1CO 0.8681
565 SF6 0.8680
566 HCI 0.8679
567 7C3 0.8674
568 SYM 0.8669
569 SGL 0.8664
570 R67 0.8663
571 W81 0.8661
572 86L 0.8661
573 4RW 0.8660
574 C2N 0.8656
575 FK8 0.8656
576 3AL 0.8652
577 7UC 0.8646
578 Q02 0.8642
579 M3H 0.8641
580 2PN 0.8626
581 HHT 0.8625
582 IPM 0.8623
583 BDR 0.8618
584 A65 0.8613
585 DLY 0.8611
586 FLC 0.8608
587 2PG 0.8608
588 QIC 0.8606
589 HL4 0.8589
590 HVQ 0.8588
591 LYS 0.8584
592 OHJ 0.8577
593 4PN 0.8565
594 CN0 0.8565
595 3QM 0.8564
596 SF9 0.8562
597 OAF 0.8561
598 2RA 0.8559
599 SYC 0.8548
600 XSP 0.8547
601 BVC 0.8545
602 GBN 0.8545
603 B3M 0.8526
604 OMD 0.8523
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2HXT; Ligand: EHM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 2hxt.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
Pocket No.: 2; Query (leader) PDB : 2HXT; Ligand: EHM; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 2) in the query (biounit: 2hxt.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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