Receptor
PDB id Resolution Class Description Source Keywords
4HOS 2 Å NON-ENZYME: IMMUNE CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN IFIT5 WITH 5`-TRIPHOS OLIGOURIDINE HOMO SAPIENS TPR RNA BINDING; ANTIVIRAL RNA RNA BINDING PROTEIN-RNA CO
Ref.: STRUCTURAL BASIS FOR VIRAL 5'-PPP-RNA RECOGNITION B IFIT PROTEINS. NATURE V. 494 60 2013
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
NA A:501;
Part of Protein;
none;
submit data
22.99 Na [Na+]
UTP U U U X:1;
Valid;
none;
submit data
1168.39 n/a [P+](...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
4HOR 1.86 Å NON-ENZYME: IMMUNE CRYSTAL STRUCTURE OF FULL-LENGTH HUMAN IFIT5 WITH 5`-TRIPHOS OLIGOCYTIDINE HOMO SAPIENS TPR RNA BINDING ANTIVIRAL RNA RNA BINDING PROTEIN-RNA CO
Ref.: STRUCTURAL BASIS FOR VIRAL 5'-PPP-RNA RECOGNITION B IFIT PROTEINS. NATURE V. 494 60 2013
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 199 families.
1 4HOR - CTP C C C C n/a n/a
2 4HOT - ATP A A A n/a n/a
3 4HOS - UTP U U U n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 65 families.
1 4HOR - CTP C C C C n/a n/a
2 4HOT - ATP A A A n/a n/a
3 4HOS - UTP U U U n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 43 families.
1 4HOR - CTP C C C C n/a n/a
2 4HOT - ATP A A A n/a n/a
3 4HOS - UTP U U U n/a n/a
4 5UDK ic50 ~ 500 nM ATP A A A n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: UTP U U U ; Similar ligands found: 40
No: Ligand ECFP6 Tc MDL keys Tc
1 UTP U U U 1 1
2 U U U U 0.75 0.953846
3 CTP C C C C 0.676768 0.925373
4 U U 0.630435 0.939394
5 UDP UDP 0.576471 0.953125
6 UDP GAL 0.525253 0.925373
7 DUT MG 0.516129 0.857143
8 UA3 0.511905 0.923077
9 U3P 0.511905 0.923077
10 PUP 0.480392 0.869565
11 UPU 0.479167 0.924242
12 U A A U 0.464567 0.826667
13 A U C C 0.458015 0.815789
14 UDP 0.456522 0.895522
15 44P 0.455556 0.857143
16 U5P 0.454545 0.909091
17 U2P 0.443182 0.880597
18 C C 0.441176 0.911765
19 A U 0.436975 0.837838
20 UTP 0.427083 0.895522
21 660 0.423077 0.884058
22 URM 0.423077 0.884058
23 G G G RPC 0.422764 0.815789
24 2KH 0.42268 0.869565
25 U 0.421687 0.818182
26 URI 0.421687 0.818182
27 U G A 0.42029 0.78481
28 UNP 0.414141 0.869565
29 UAD 0.411215 0.897059
30 UDX 0.411215 0.897059
31 CSV 0.410714 0.835616
32 CSQ 0.410714 0.835616
33 GUD 0.409524 0.897059
34 UFM 0.409524 0.897059
35 GDU 0.409524 0.897059
36 UPG 0.409524 0.897059
37 CJB 0.406977 0.80303
38 Y6W 0.40566 0.847222
39 APU 0.401639 0.813333
40 UDH 0.4 0.8
Similar Binding Sites (Proteins are less than 50% similar to leader)
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