Receptor
PDB id Resolution Class Description Source Keywords
6DO5 2.5 Å NON-ENZYME: OTHER KLHDC2 UBIQUITIN LIGASE IN COMPLEX WITH USP1 C-END DEGRON HOMO SAPIENS KELCH REPEAT BETA-PROPELLER DEGRON COMPLEX SUBSTRATE RECE3 UBIQUITIN LIGASE LIGASE
Ref.: RECOGNITION OF THE DIGLYCINE C-END DEGRON BY CRL2KLHDC2UBIQUITIN LIGASE. MOL. CELL V. 72 813 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ILE GLY LEU LEU GLY GLY C:666;
D:666;
 Valid;
Valid;
 Atoms found LESS than expected: % Diff = 0.081;
Atoms found LESS than expected: % Diff = 0.081;
 submit data
486.57 n/a O=C(N...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6DO3 2.17 Å NON-ENZYME: OTHER KLHDC2 UBIQUITIN LIGASE IN COMPLEX WITH SELK C-END DEGRON HOMO SAPIENS KELCH REPEAT BETA-PROPELLER DEGRON COMPLEX SUBSTRATE RECE3 UBIQUITIN LIGASE LIGASE
Ref.: RECOGNITION OF THE DIGLYCINE C-END DEGRON BY CRL2KLHDC2UBIQUITIN LIGASE. MOL. CELL V. 72 813 2018
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1610 families.
1 6DO3 - PRO PRO PRO MET ALA GLY GLY n/a n/a
2 6DO5 - ILE GLY LEU LEU GLY GLY n/a n/a
3 6DO4 - GLY PRO SER SER GLY GLY n/a n/a
70% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1331 families.
1 6DO3 - PRO PRO PRO MET ALA GLY GLY n/a n/a
2 6DO5 - ILE GLY LEU LEU GLY GLY n/a n/a
3 6DO4 - GLY PRO SER SER GLY GLY n/a n/a
50% Homology Family (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 1144 families.
1 6DO3 - PRO PRO PRO MET ALA GLY GLY n/a n/a
2 6DO5 - ILE GLY LEU LEU GLY GLY n/a n/a
3 6DO4 - GLY PRO SER SER GLY GLY n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: ILE GLY LEU LEU GLY GLY; Similar ligands found: 6
No: Ligand ECFP6 Tc MDL keys Tc
1 ILE GLY LEU LEU GLY GLY 1 1
2 LEU GLY GLY 0.491803 0.95
3 PRO LEU GLY GLY 0.479452 0.829787
4 CYS LEU GLY GLY LEU LEU THR MET VAL 0.443299 0.764706
5 THR LEU MET THR GLY GLN LEU GLY LEU PHE 0.417582 0.863636
6 ALA LEU GLY ILE GLY ILE LEU THR VAL 0.4 0.826087
Similar Ligands (3D)
Ligand no: 1; Ligand: ILE GLY LEU LEU GLY GLY; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6DO3; Ligand: PRO PRO PRO MET ALA GLY GLY; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6do3.bio2) has 22 residues
No: Leader PDB Ligand Sequence Similarity
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