Receptor
PDB id Resolution Class Description Source Keywords
6evp 1.68 Å EC: 1.14.11.2 CRYSTAL STRUCTURE THE PEPTIDE-SUBSTRATE-BINDING DOMAIN OF HU II COLLAGEN PROLYL 4-HYDROXYLASE COMPLEXED WITH PRO-PRO-GLYG LY-PRO-PRO-GLY. HOMO SAPIENS TETRATRICOPEPTIDE REPEAT COLLAGEN SYNTHESIS PROLYL 4-HYDROHYDROLASE
Ref.: STRUCTURAL ENZYMOLOGY BINDING STUDIES OF THE PEPTIDE-SUBSTRATE-BINDING DOMAIN OF HUMAN COLLAGEN 4-HYDROXYLASE (TYPE-II): HIGH AFFINITY PEPTIDES HAV SEQUENCE MOTIF. PROTEIN SCI. V. 27 1692 2018
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
DMS A:302;
A:303;
A:304;
 Invalid;
Invalid;
Invalid;
 none;
none;
none;
 submit data
78.133 C2 H6 O S CS(=O...
PRO PRO GLY PRO GLU GLY PRO PRO GLY C:2;
 Valid;
 Atoms found LESS than expected: % Diff = 0.018;
 submit data
705.746 n/a O=C(N...
SO4 A:301;
 Invalid;
 none;
 submit data
96.063 O4 S [O-]S...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
6EVN 1.48 Å EC: 1.14.11.2 CRYSTAL STRUCTURE OF PEPTIDE-SUBSTRATE-BINDING DOMAIN OF HUM COLLAGEN PROLYL 4-HYDROXYLASE COMPLEX WITH PRO-PRO-GLY-PRO-P RO-PRO-GLY. HOMO SAPIENS TETRATRICOPEPTIDE REPEAT COLLAGEN SYNTHESIS PROLYL 4-HYDROHYDROLASE
Ref.: STRUCTURAL ENZYMOLOGY BINDING STUDIES OF THE PEPTIDE-SUBSTRATE-BINDING DOMAIN OF HUMAN COLLAGEN 4-HYDROXYLASE (TYPE-II): HIGH AFFINITY PEPTIDES HAV SEQUENCE MOTIF. PROTEIN SCI. V. 27 1692 2018
Members (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 6EVM - PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 6EVP - PRO PRO GLY PRO GLU GLY PRO PRO GLY n/a n/a
3 6EVN - PRO PRO GLY PRO ALA GLY PRO PRO GLY n/a n/a
4 6EVO - PRO PRO GLY PRO ARG GLY PRO PRO GLY n/a n/a
70% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 6EVM - PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 6EVP - PRO PRO GLY PRO GLU GLY PRO PRO GLY n/a n/a
3 6EVN - PRO PRO GLY PRO ALA GLY PRO PRO GLY n/a n/a
4 6EVO - PRO PRO GLY PRO ARG GLY PRO PRO GLY n/a n/a
50% Homology Family (4)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 2 families.
1 6EVM - PRO PRO PRO PRO PRO PRO PRO PRO PRO n/a n/a
2 6EVP - PRO PRO GLY PRO GLU GLY PRO PRO GLY n/a n/a
3 6EVN - PRO PRO GLY PRO ALA GLY PRO PRO GLY n/a n/a
4 6EVO - PRO PRO GLY PRO ARG GLY PRO PRO GLY n/a n/a
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: PRO PRO GLY PRO GLU GLY PRO PRO GLY; Similar ligands found: 10
No: Ligand ECFP6 Tc MDL keys Tc
1 PRO PRO GLY PRO GLU GLY PRO PRO GLY 1 1
2 PRO PRO GLY PRO ARG GLY PRO PRO GLY 0.688073 0.894737
3 PRO PRO GLY PRO ALA GLY PRO PRO GLY 0.634615 0.962264
4 PRO PRO GLY PRO PRO GLY PRO PRO GLY 0.623656 0.980392
5 PRO GLY PRO 0.5 0.980392
6 PRO GLY PRO LEU PRO ALA 0.5 0.927273
7 PRO PRO PRO MET ALA GLY GLY 0.45082 0.864407
8 PRO GLU ALA THR ALA PRO PRO GLU GLU 0.434109 0.864407
9 PRO GLU PRO THR ALA PRO PRO GLU GLU 0.427481 0.864407
10 ACE CYS HIS PRO GLN GLY PRO PRO CYS NH2 0.401408 0.830508
Similar Ligands (3D)
Ligand no: 1; Ligand: PRO PRO GLY PRO GLU GLY PRO PRO GLY; Similar ligands found: 0
No: Ligand Similarity coefficient
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 6EVN; Ligand: PRO PRO GLY PRO ALA GLY PRO PRO GLY; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 6evn.bio1) has 13 residues
No: Leader PDB Ligand Sequence Similarity
APoc FAQ
Feedback