Receptor
PDB id Resolution Class Description Source Keywords
2Q93 1.6 Å EC: 3.4.11.18 E. COLI METHIONINE AMINOPEPTIDASE MN-FORM WITH INHIBITOR B21 ESCHERICHIA COLI AMINOPEPTIDASE HYDROLASE DINUCLEAR MN(II)-FORM ENZYME- INHIBITOR COMPLEX METALLOENZYME
Ref.: STRUCTURAL ANALYSIS OF INHIBITION OF E. COLI METHIONINE AMINOPEPTIDASE: IMPLICATION OF LOOP FLEXIBILITY IN SELECTIVE INHIBITION OF BACTERIAL ENZYMES. BMC STRUCT.BIOL. V. 7 84 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
B21 A:400;
 Valid;
 none;
 ic50 = 0.56 uM
218.205 C12 H10 O4 COc1c...
MN A:301;
A:302;
 Part of Protein;
Part of Protein;
 none;
none;
 submit data
54.938 Mn [Mn+2...
NA A:500;
 Part of Protein;
 none;
 submit data
22.99 Na [Na+]
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
1YVM 1.6 Å EC: 3.4.11.18 E. COLI METHIONINE AMINOPEPTIDASE IN COMPLEX WITH THIABENDAZOLE ESCHERICHIA COLI HYDROLASE(ALPHA-AMINOACYLPEPTIDE) METAL COMPLEX THIABENDAZOLE METHIONINE AMINOPEPTIDASE INHIBITOR
Ref.: METAL IONS AS COFACTORS FOR THE BINDING OF INHIBITORS TO METHIONINE AMINOPEPTIDASE: A CRITICAL VIEW OF THE RELEVANCE OF IN VITRO METALLOENZYME ASSAYS. ANGEW.CHEM.INT.ED.ENGL. V. 44 3620 2005
Members (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 8 families.
1 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
2 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
3 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
4 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
5 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
6 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
7 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
8 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
9 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
10 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
11 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
12 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
13 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
14 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
15 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
16 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
17 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
18 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
19 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
20 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
21 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
22 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
23 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
24 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
25 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
26 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
27 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
28 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
29 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
30 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
31 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
32 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
33 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
34 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
35 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
36 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
70% Homology Family (36)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 6 families.
1 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
2 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
3 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
4 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
5 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
6 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
7 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
8 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
9 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
10 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
11 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
12 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
13 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
14 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
15 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
16 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
17 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
18 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
19 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
20 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
21 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
22 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
23 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
24 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
25 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
26 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
27 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
28 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
29 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
30 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
31 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
32 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
33 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
34 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
35 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
36 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
50% Homology Family (69)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 3 families.
1 2NQ6 ic50 = 1.5 uM HM4 C14 H16 N4 O3 S CC(C)(C)OC....
2 4U69 Ki = 54.8 uM Q07 C6 H16 N O3 P CCC[C@H](C....
3 2G6P ic50 = 0.6 uM HM2 C18 H17 Cl N4 Cc1c(c(nc(....
4 4U73 Ki = 6.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
5 4IKT ic50 = 0.67 uM TFV C18 H16 Cl F3 N6 Cc1c(c(nc(....
6 4U6Z Ki = 3.9 uM Q07 C6 H16 N O3 P CCC[C@H](C....
7 4U70 Ki = 9.5 uM Q04 C8 H18 N O3 P C1CCC(CC1)....
8 4FLI ic50 = 3.59 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
9 4U6C Ki = 9.9 uM Q06 C8 H18 N O3 P C1CCC(C1)C....
10 4IKR ic50 = 0.59 uM PVP C16 H20 Cl N5 O Cc1c(c(nc(....
11 4FLK ic50 = 5.58 uM Y10 C21 H31 N O5 CC(C)(C)/C....
12 4IKU ic50 = 1.79 uM SHX C19 H18 Cl N5 O Cc1c(c(nc(....
13 2NQ7 ic50 = 2.9 uM HM5 C14 H16 N4 O2 S CC(C)(C)C(....
14 4FLL ic50 = 5.14 uM YZ6 C25 H35 N O6 CC(C)(C)/C....
15 4U71 Ki = 6 uM Q03 C7 H16 N O3 P C1CCC(CC1)....
16 4HXX - 1AY C28 H29 Cl2 N5 Cc1c(c(nc(....
17 4IKS ic50 = 7.23 uM TFD C18 H16 Cl F3 N6 Cc1c(c(nc(....
18 4U6E Ki = 111.6 uM Q02 C7 H10 N O3 P c1ccc(cc1)....
19 4U1B Ki = 4.9 uM Q08 C8 H20 N O3 P CCCC(CCC)[....
20 4FLJ ic50 = 7.45 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
21 2GG0 ic50 = 1.7 uM U11 C16 H20 F3 N3 O5 C[C@@H](C(....
22 1YVM Ki = 0.4 uM TMG C10 H7 N3 S c1ccc2c(c1....
23 2GU6 - NLP C5 H14 N O3 P CCCC[C@H](....
24 2Q95 ic50 = 1.6 uM A05 C11 H6 Cl N O5 c1cc(c(cc1....
25 2GG8 ic50 = 25 uM U15 C20 H31 N3 O5 Cc1ccc(cc1....
26 2GTX - NLP C5 H14 N O3 P CCCC[C@H](....
27 2EVC ic50 = 0.29 uM FC3 C12 H7 F3 O3 c1ccc(c(c1....
28 4A6W ic50 = 1.9 uM 5C1 C10 H7 Cl N2 O3 c1ccc(c(c1....
29 2GG3 ic50 = 0.58 uM U13 C9 H7 F N6 [H]/N=C/1C....
30 3D27 ic50 = 55.7 uM W29 C12 H12 O2 S CCc1ccsc1c....
31 2GG7 ic50 = 1.75 uM U14 C10 H8 N6 O2 [H]/N=C1/C....
32 2GU5 - NLP C5 H14 N O3 P CCCC[C@H](....
33 1XNZ ic50 = 0.24 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
34 4A6V ic50 = 1.9 uM IKY C11 H7 F3 N2 O3 c1ccc(c(c1....
35 1C21 - MET C5 H11 N O2 S CSCC[C@@H]....
36 2Q92 ic50 = 1.1 uM B23 C11 H7 N O5 c1ccc(c(c1....
37 1C27 - NLP C5 H14 N O3 P CCCC[C@H](....
38 1C24 - MPJ C4 H12 N O2 P S CSCC[C@H](....
39 2EVO ic50 = 0.067 uM CT0 C10 H13 N3 O2 S c1csc(n1)N....
40 2P99 ic50 = 1.16 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
41 2GG9 ic50 = 3.5 uM U16 C22 H35 N3 O5 CC(C)C[C@H....
42 2Q94 ic50 = 0.37 uM A04 C12 H7 F3 O4 c1ccc(c(c1....
43 2P98 ic50 = 0.64 uM YE7 C12 H10 N4 O c1ccc2c(c1....
44 2GGB ic50 = 12 uM U17 C17 H33 N3 O6 CCCC[C@H](....
45 2EVM ic50 = 0.693 uM FC2 C11 H6 Cl2 O3 c1cc(c(cc1....
46 1C22 - MF3 C5 H8 F3 N O2 S C(CSC(F)(F....
47 1C23 - MPH C4 H12 N O3 P S CSCC[C@H](....
48 2Q96 ic50 = 1.2 uM A18 C12 H9 Cl O3 c1ccc(c(c1....
49 2BB7 ic50 = 2.14 uM QMS C10 H10 N2 O2 S CS(=O)(=O)....
50 2GG2 ic50 = 0.25 uM U12 C10 H7 F3 N6 c1cc(cc(c1....
51 2GGC - MET C5 H11 N O2 S CSCC[C@@H]....
52 2GU4 - NLP C5 H14 N O3 P CCCC[C@H](....
53 2Q93 ic50 = 0.56 uM B21 C12 H10 O4 COc1ccccc1....
54 2GG5 ic50 = 0.25 uM U19 C10 H7 F3 N6 [H]/N=C1/C....
55 3MAT - AHH ALA LEU VAL 0A9 n/a n/a
56 2P9A ic50 = 6.56 uM YE6 C11 H9 Cl N2 O2 c1ccc(c(c1....
57 4IU6 - FZ1 C24 H23 N5 O COc1ccc(cc....
58 1QXZ ic50 = 19 uM M3C C8 H14 N2 O2 S2 CSCC[C@@H]....
59 1QXY ic50 = 16 uM M2C C10 H16 N2 O2 S CSCC[C@@H]....
60 1QXW ic50 = 7 uM M1C C10 H22 N2 O2 CCCC[C@@H]....
61 3IU9 ic50 = 0.24 uM T07 C9 H8 Cl2 N4 S c1cc(c(cc1....
62 3IU7 ic50 = 16 uM FCD C11 H7 Cl O3 c1ccc(c(c1....
63 3PKE - Y10 C21 H31 N O5 CC(C)(C)/C....
64 3PKB ic50 = 0.62 uM Y16 C14 H26 N2 O6 CC(C)(C)/C....
65 3PKA ic50 = 0.54 uM Y02 C23 H37 N O6 Cc1cc(c(c(....
66 3PKC ic50 = 0.96 uM Y08 C22 H38 N2 O6 CC(C)(C)/C....
67 3IU8 ic50 = 0.58 uM T03 C9 H8 F N3 S c1cc(ccc1C....
68 3PKD ic50 = 0.76 uM Y10 C21 H31 N O5 CC(C)(C)/C....
69 1YJ3 - MET C5 H11 N O2 S CSCC[C@@H]....
Polypharmacology
Similar Ligands (2D)
Ligand no: 1; Ligand: B21; Similar ligands found: 5
No: Ligand ECFP6 Tc MDL keys Tc
1 B21 1 1
2 A04 0.666667 0.794118
3 FCD 0.509434 0.666667
4 FC3 0.473684 0.628571
5 EAJ 0.409836 0.733333
Similar Ligands (3D)
Ligand no: 1; Ligand: B21; Similar ligands found: 731
No: Ligand Similarity coefficient
1 B23 0.9631
2 FC2 0.9621
3 PQT 0.9606
4 2K8 0.9574
5 5C1 0.9559
6 YE6 0.9544
7 TJM 0.9511
8 JF8 0.9451
9 WVV 0.9403
10 MD6 0.9390
11 EQA 0.9382
12 KCH 0.9376
13 HA6 0.9370
14 HHS 0.9366
15 N0Z 0.9365
16 JP2 0.9358
17 AUV 0.9350
18 5WT 0.9339
19 V1T 0.9324
20 3VQ 0.9317
21 HBO 0.9309
22 PH2 0.9309
23 BIO 0.9294
24 C0W 0.9291
25 3GV 0.9286
26 9UL 0.9272
27 G14 0.9269
28 774 0.9267
29 ZZA 0.9266
30 D9Z 0.9265
31 P83 0.9247
32 0FR 0.9243
33 Q9T 0.9235
34 5TY 0.9224
35 1SF 0.9219
36 A7K 0.9215
37 2JK 0.9214
38 YE7 0.9213
39 ZHA 0.9213
40 8HC 0.9210
41 5VU 0.9204
42 TCR 0.9199
43 7ZL 0.9199
44 ELH 0.9198
45 4ZF 0.9197
46 BZE 0.9196
47 W29 0.9188
48 ZSP 0.9186
49 PUE 0.9185
50 6ZW 0.9181
51 ZYQ 0.9180
52 9F8 0.9172
53 FF2 0.9172
54 ODK 0.9168
55 ZRK 0.9166
56 HBI 0.9165
57 JTA 0.9163
58 CK2 0.9162
59 TOH 0.9162
60 H4B 0.9158
61 1A7 0.9154
62 DXK 0.9152
63 HRM 0.9152
64 55D 0.9151
65 ITE 0.9148
66 7L4 0.9145
67 ZME 0.9145
68 GNV 0.9144
69 0FK 0.9143
70 IKY 0.9141
71 ONZ 0.9140
72 78Y 0.9138
73 QIV 0.9135
74 C0H 0.9133
75 0XT 0.9131
76 ZYR 0.9127
77 JMG 0.9123
78 1XS 0.9120
79 DK1 0.9118
80 0SY 0.9117
81 F2W 0.9114
82 GZV 0.9113
83 S60 0.9111
84 6MW 0.9108
85 9JT 0.9108
86 ZRL 0.9107
87 WSD 0.9101
88 ANC 0.9101
89 BGU 0.9100
90 795 0.9100
91 4FF 0.9096
92 YEX 0.9093
93 X11 0.9092
94 TIA 0.9091
95 CHQ 0.9091
96 537 0.9089
97 1ER 0.9086
98 GXD 0.9085
99 FHV 0.9082
100 8G6 0.9079
101 BDI 0.9078
102 AVX 0.9078
103 F40 0.9077
104 0NX 0.9071
105 AMR 0.9070
106 AVA 0.9065
107 3TC 0.9065
108 BBY 0.9064
109 JGB 0.9063
110 6QF 0.9060
111 CBE 0.9059
112 IDZ 0.9056
113 DNQ 0.9055
114 C9E 0.9053
115 EGR 0.9051
116 9CE 0.9049
117 2GQ 0.9045
118 4AU 0.9042
119 S98 0.9040
120 JY4 0.9037
121 7I2 0.9037
122 TIZ 0.9034
123 CNI 0.9032
124 C53 0.9032
125 Y3L 0.9031
126 6J5 0.9031
127 O82 0.9031
128 A5H 0.9030
129 KLE 0.9029
130 MR6 0.9028
131 LJ3 0.9027
132 5FL 0.9026
133 LR2 0.9026
134 N2M 0.9026
135 RBV 0.9025
136 26C 0.9025
137 NE2 0.9024
138 27M 0.9024
139 4G2 0.9022
140 JFS 0.9021
141 1AJ 0.9020
142 RGK 0.9019
143 6TJ 0.9019
144 5P3 0.9016
145 D3G 0.9015
146 AH9 0.9014
147 3D8 0.9013
148 344 0.9013
149 4XF 0.9013
150 OSB 0.9013
151 OX2 0.9013
152 8D6 0.9012
153 N8Y 0.9012
154 MR4 0.9011
155 TMG 0.9010
156 GI1 0.9010
157 UFO 0.9009
158 MUX 0.9008
159 4Z1 0.9007
160 MXD 0.9007
161 LL1 0.9006
162 MBP 0.9004
163 2D2 0.9004
164 272 0.9004
165 NKI 0.9002
166 SQ4 0.9000
167 30G 0.9000
168 LAH 0.8997
169 DFL 0.8996
170 2WU 0.8994
171 FPL 0.8992
172 ZIP 0.8992
173 GO8 0.8991
174 K48 0.8991
175 5WK 0.8988
176 LFQ 0.8988
177 5F8 0.8987
178 KLV 0.8987
179 4GU 0.8985
180 6FB 0.8985
181 BQ5 0.8984
182 1FL 0.8983
183 5WS 0.8983
184 XI7 0.8982
185 DTR 0.8979
186 2FQ 0.8979
187 GXG 0.8978
188 WOE 0.8978
189 0K7 0.8977
190 64E 0.8977
191 5V7 0.8977
192 LOT 0.8977
193 THA 0.8976
194 UN9 0.8976
195 E35 0.8976
196 2FX 0.8975
197 5XL 0.8974
198 ADN 0.8974
199 D2G 0.8974
200 M02 0.8974
201 A73 0.8973
202 5H6 0.8972
203 NIR 0.8972
204 3QV 0.8971
205 18E 0.8971
206 8CC 0.8970
207 79W 0.8969
208 1QP 0.8969
209 BIK 0.8968
210 BZJ 0.8966
211 2LW 0.8966
212 HNL 0.8963
213 6J3 0.8961
214 TRP 0.8961
215 AJD 0.8960
216 SQ7 0.8960
217 5E5 0.8959
218 78U 0.8958
219 CH9 0.8958
220 5TZ 0.8958
221 MZR 0.8958
222 Q5M 0.8957
223 DRG 0.8957
224 SLY 0.8956
225 EAT 0.8956
226 VXX 0.8956
227 WLH 0.8956
228 61M 0.8956
229 47V 0.8956
230 4V2 0.8955
231 28A 0.8953
232 B2T 0.8953
233 1V1 0.8953
234 20D 0.8952
235 8HH 0.8952
236 L22 0.8952
237 L1T 0.8951
238 CK1 0.8950
239 GNJ 0.8950
240 LTN 0.8949
241 ACE TRP 0.8949
242 D1Y 0.8949
243 3D3 0.8948
244 K80 0.8946
245 LZ5 0.8946
246 GO2 0.8945
247 WL3 0.8945
248 68A 0.8944
249 5B2 0.8943
250 RA7 0.8942
251 X0W 0.8942
252 D8Q 0.8942
253 JRO 0.8941
254 VM1 0.8940
255 KYN 0.8938
256 BHS 0.8937
257 P9I 0.8936
258 3Y7 0.8933
259 M4N 0.8933
260 ZEA 0.8933
261 N91 0.8932
262 MJW 0.8930
263 FQX 0.8929
264 JWS 0.8929
265 U13 0.8929
266 P4L 0.8927
267 372 0.8927
268 I2E 0.8925
269 8W9 0.8923
270 3SU 0.8922
271 DT7 0.8919
272 F16 0.8917
273 WS7 0.8917
274 8UY 0.8916
275 DUR 0.8916
276 E1K 0.8915
277 FER 0.8914
278 NOS 0.8914
279 25F 0.8913
280 1V3 0.8912
281 BP7 0.8909
282 BA5 0.8907
283 BPU 0.8906
284 67Y 0.8904
285 3J8 0.8904
286 X48 0.8902
287 A9B 0.8902
288 3VX 0.8902
289 SG2 0.8901
290 4F8 0.8901
291 ZYV 0.8900
292 LUM 0.8898
293 5E4 0.8898
294 JR2 0.8897
295 7O4 0.8896
296 V2Z 0.8895
297 CSN 0.8894
298 CX6 0.8893
299 F18 0.8892
300 3D1 0.8892
301 B1J 0.8891
302 Q0K 0.8890
303 G30 0.8889
304 ESI 0.8889
305 5GV 0.8888
306 6Q3 0.8888
307 64C 0.8887
308 WUB 0.8887
309 KMY 0.8886
310 B2E 0.8885
311 3B4 0.8885
312 BZQ 0.8884
313 2QU 0.8880
314 833 0.8880
315 FZM 0.8879
316 5NN 0.8879
317 BQ2 0.8878
318 H35 0.8876
319 M83 0.8875
320 GNM 0.8874
321 IOP 0.8874
322 TQ1 0.8874
323 RVE 0.8873
324 JCZ 0.8873
325 SOV 0.8873
326 TB8 0.8872
327 TCC 0.8872
328 MPP 0.8872
329 SYE 0.8871
330 9BF 0.8870
331 NQH 0.8870
332 TBN 0.8870
333 VAO 0.8868
334 H4E 0.8867
335 XM5 0.8866
336 AH3 0.8864
337 BPY 0.8864
338 G6P 0.8864
339 OCZ 0.8862
340 WS6 0.8862
341 IXM 0.8861
342 R9Y 0.8861
343 3F4 0.8861
344 MR5 0.8860
345 HX4 0.8860
346 XCG 0.8860
347 E9S 0.8860
348 JG8 0.8860
349 0LO 0.8860
350 ERZ 0.8856
351 X0U 0.8855
352 1V4 0.8855
353 SYR 0.8854
354 M3F 0.8854
355 1DR 0.8853
356 BIE 0.8852
357 2J1 0.8852
358 0UL 0.8852
359 4AB 0.8851
360 ANF 0.8851
361 MUR 0.8850
362 II4 0.8850
363 KP2 0.8850
364 54X 0.8849
365 0JD 0.8849
366 U19 0.8849
367 M5H 0.8849
368 F5C 0.8847
369 RUG 0.8847
370 5WM 0.8846
371 RKV 0.8846
372 Q4G 0.8845
373 1Z6 0.8845
374 5E1 0.8845
375 M01 0.8844
376 HH6 0.8842
377 2JX 0.8841
378 BG6 0.8840
379 IQQ 0.8840
380 9OF 0.8840
381 2UD 0.8840
382 PRL 0.8839
383 363 0.8839
384 CCV 0.8838
385 GOE 0.8838
386 L03 0.8838
387 KTW 0.8837
388 SXX 0.8837
389 L2K 0.8837
390 5F5 0.8836
391 JF1 0.8836
392 NRA 0.8835
393 4Z3 0.8835
394 H2B 0.8834
395 S1D 0.8834
396 CX4 0.8834
397 3GX 0.8833
398 78P 0.8833
399 XIF XYP 0.8832
400 19E 0.8831
401 LEL 0.8831
402 J38 0.8831
403 4A1 0.8829
404 1QV 0.8828
405 AYS 0.8828
406 QBS 0.8828
407 64F 0.8827
408 JSX 0.8825
409 RSV 0.8825
410 6X9 0.8825
411 AN3 0.8824
412 92G 0.8823
413 E1T 0.8823
414 PLP 0.8822
415 EVO 0.8822
416 3R4 0.8822
417 DAH 0.8822
418 L5D 0.8822
419 7MX 0.8821
420 DPT 0.8821
421 X2M 0.8821
422 5WN 0.8820
423 ALE 0.8820
424 S8D 0.8820
425 VBC 0.8818
426 EWG 0.8818
427 D1G 0.8818
428 IL5 0.8817
429 K68 0.8816
430 1FE 0.8816
431 68B 0.8815
432 M78 0.8814
433 AJG 0.8813
434 2P3 0.8813
435 9FH 0.8812
436 KW7 0.8812
437 1KN 0.8811
438 MPK 0.8810
439 4R1 0.8810
440 CC5 0.8810
441 B4O 0.8809
442 PIQ 0.8809
443 YZM 0.8809
444 6KT 0.8808
445 PMP 0.8803
446 MFR 0.8803
447 ALR 0.8803
448 IWT 0.8802
449 6QT 0.8800
450 EN1 0.8799
451 ARJ 0.8797
452 HHV 0.8794
453 EE8 0.8792
454 DX7 0.8791
455 3VW 0.8790
456 JF2 0.8790
457 HJH 0.8790
458 NFZ 0.8790
459 1ZC 0.8789
460 1A5 0.8789
461 8NX 0.8789
462 SJK 0.8789
463 5AD 0.8788
464 PCQ 0.8788
465 X8E 0.8788
466 SZ5 0.8787
467 THM 0.8786
468 0RY 0.8786
469 2QV 0.8784
470 4Z9 0.8783
471 XFE 0.8782
472 15N 0.8782
473 0W1 0.8781
474 OA1 0.8780
475 TXQ 0.8780
476 BVS 0.8779
477 GZ2 0.8779
478 Z15 0.8779
479 8NB 0.8779
480 A6W 0.8778
481 E7S 0.8777
482 C4E 0.8775
483 6J9 0.8775
484 FNT 0.8774
485 IMH 0.8774
486 GHM 0.8773
487 C09 0.8773
488 9AP 0.8772
489 N7I 0.8771
490 5VL 0.8770
491 CTN 0.8770
492 HRD 0.8770
493 12R 0.8769
494 X0T 0.8768
495 KTJ 0.8768
496 FMQ 0.8768
497 692 0.8767
498 5GT 0.8766
499 NOC 0.8764
500 ENO 0.8764
501 Z57 0.8763
502 FMB 0.8763
503 IQZ 0.8762
504 TLF 0.8762
505 E9L 0.8761
506 5UD 0.8760
507 22L 0.8760
508 UN4 0.8757
509 URI 0.8756
510 2LT 0.8756
511 AP6 0.8752
512 36M 0.8751
513 PYU 0.8751
514 MOK 0.8750
515 28B 0.8750
516 0DF 0.8750
517 AKD 0.8749
518 7VP 0.8749
519 ID8 0.8749
520 GJK 0.8748
521 NIY 0.8748
522 NW1 0.8747
523 5AE 0.8747
524 DBS 0.8746
525 9TF 0.8746
526 IA2 0.8744
527 49P 0.8744
528 38E 0.8742
529 492 0.8741
530 I5A 0.8741
531 3VS 0.8741
532 8M5 0.8739
533 A05 0.8737
534 SNY 0.8737
535 4I5 0.8736
536 5ER 0.8736
537 TAL 0.8736
538 GVI 0.8733
539 PXP 0.8733
540 LDR 0.8733
541 CZ0 0.8732
542 AH6 0.8730
543 TH4 0.8730
544 7AP 0.8729
545 XDK 0.8729
546 NE1 0.8729
547 YZ9 0.8729
548 XDN XYP 0.8727
549 XYP XDN 0.8727
550 2KU 0.8726
551 MHB 0.8726
552 EST 0.8726
553 L21 0.8725
554 GNY 0.8724
555 57D 0.8723
556 4I8 0.8722
557 96Z 0.8721
558 2GD 0.8721
559 AD3 0.8719
560 NFK 0.8719
561 AY4 0.8717
562 G1P 0.8716
563 3N0 0.8715
564 CMG 0.8715
565 TT4 0.8714
566 ARP 0.8713
567 BGP 0.8713
568 1KP 0.8713
569 K25 0.8712
570 UA2 0.8710
571 A63 0.8709
572 5S9 0.8709
573 CKA 0.8708
574 AC2 0.8708
575 SKF 0.8707
576 4BL 0.8707
577 1X8 0.8707
578 4MU 0.8707
579 4GP 0.8705
580 IK1 0.8705
581 28N 0.8705
582 4NR 0.8703
583 XYP XIF 0.8703
584 H2W 0.8702
585 WCU 0.8701
586 4BY 0.8699
587 ATX 0.8699
588 HA5 0.8699
589 AGI 0.8698
590 39O 0.8696
591 AZC 0.8694
592 CTD 0.8692
593 A5Q 0.8692
594 CFK 0.8691
595 4CN 0.8689
596 6BK 0.8688
597 SSY 0.8688
598 JAH 0.8688
599 9ZE 0.8688
600 VT3 0.8687
601 5F1 0.8687
602 CDJ 0.8686
603 S0D 0.8686
604 GB4 0.8685
605 W8L 0.8683
606 LLT 0.8682
607 CTE 0.8682
608 PUR 0.8680
609 5I5 0.8679
610 DHC 0.8678
611 PPY 0.8677
612 4HB 0.8677
613 KF5 0.8675
614 DT9 0.8675
615 EV2 0.8674
616 92P 0.8674
617 6PB 0.8673
618 CMU 0.8672
619 AJ1 0.8671
620 H70 0.8670
621 M3W 0.8670
622 KW8 0.8669
623 2UZ 0.8669
624 3Q0 0.8666
625 6DQ 0.8665
626 5FD 0.8665
627 C82 0.8665
628 B0K 0.8663
629 U7E 0.8658
630 DBQ 0.8658
631 SQV 0.8656
632 7FZ 0.8655
633 XDL XYP 0.8655
634 4BX 0.8655
635 XIL 0.8655
636 3WL 0.8653
637 E3X 0.8652
638 6H2 0.8650
639 97K 0.8650
640 SLS 0.8649
641 P7Y 0.8646
642 AJY 0.8644
643 AOY 0.8643
644 NIF 0.8643
645 4LW 0.8642
646 EMU 0.8641
647 657 0.8640
648 CIY 0.8638
649 URD 0.8637
650 WV7 0.8636
651 3XH 0.8634
652 QMS 0.8633
653 GAT 0.8632
654 HNK 0.8632
655 PVK 0.8632
656 43U 0.8631
657 FCW 0.8630
658 DDU 0.8630
659 7MW 0.8630
660 5N5 0.8629
661 3LJ 0.8627
662 NU3 0.8627
663 CDY 0.8627
664 ARG 0.8626
665 878 0.8626
666 9DI 0.8623
667 G12 0.8620
668 ENG 0.8619
669 6HP 0.8618
670 2LX 0.8616
671 UKV 0.8616
672 CJZ 0.8614
673 N2I 0.8610
674 FBC 0.8608
675 A4V 0.8606
676 15E 0.8604
677 PVQ 0.8604
678 5SJ 0.8603
679 MW5 0.8601
680 ABF 0.8601
681 VUP 0.8600
682 EXD 0.8599
683 XYP XYP 0.8599
684 3L1 0.8597
685 DCZ 0.8597
686 6C9 0.8596
687 6C8 0.8593
688 NAG 0.8592
689 KYA 0.8592
690 XEZ 0.8591
691 SWX 0.8590
692 L07 0.8588
693 IAC 0.8585
694 LR8 0.8582
695 I7C 0.8578
696 O2Y 0.8578
697 KDV 0.8575
698 GLP 0.8575
699 1EL 0.8573
700 GF4 0.8573
701 C2Y 0.8571
702 D25 0.8570
703 8OB 0.8568
704 XYS XYP 0.8567
705 Z21 0.8567
706 3C5 0.8567
707 OPA 0.8563
708 PEY 0.8560
709 LFN 0.8557
710 TZP 0.8556
711 N9J 0.8555
712 08C 0.8554
713 KLS 0.8553
714 K44 0.8553
715 MTA 0.8552
716 LJ4 0.8551
717 GVY 0.8551
718 56N 0.8545
719 A1Y 0.8544
720 A18 0.8544
721 PBQ 0.8540
722 AQN 0.8540
723 GDL 0.8538
724 I59 0.8538
725 1HP 0.8536
726 92O 0.8535
727 9FE 0.8534
728 Y3J 0.8531
729 KU1 0.8530
730 GC2 0.8525
731 NWD 0.8518
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 1YVM; Ligand: TMG; Similar sites found with APoc: No similar binding sites found, or similarity not calculated due to duplicate pocket.
This union binding pocket(no: 1) in the query (biounit: 1yvm.bio1) has 18 residues
No: Leader PDB Ligand Sequence Similarity
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