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Receptor
PDB id Resolution Class Description Source Keywords
2AK5 1.85 Å NON-ENZYME: SIGNAL_HORMONE BETA PIX-SH3 COMPLEXED WITH A CBL-B PEPTIDE RATTUS NORVEGICUS ADAPTOR PROTEINS CIN85 PIX/COOL CBL PROTEIN-PROTEIN INTERACTION X-RAY ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: CBL PROMOTES CLUSTERING OF ENDOCYTIC ADAPTOR PROTEINS. NAT.STRUCT.MOL.BIOL. V. 12 972 2005
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ARG PRO PRO LYS PRO ARG PRO ARG D:904;
Valid;
none;
Kd = 14 uM n/a n/a n/a n/a
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90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2AK5 1.85 Å NON-ENZYME: SIGNAL_HORMONE BETA PIX-SH3 COMPLEXED WITH A CBL-B PEPTIDE RATTUS NORVEGICUS ADAPTOR PROTEINS CIN85 PIX/COOL CBL PROTEIN-PROTEIN INTERACTION X-RAY ENDOCYTOSIS ENDOCYTOSIS/EXOCYTOSIS COMPLEX
Ref.: CBL PROMOTES CLUSTERING OF ENDOCYTIC ADAPTOR PROTEINS. NAT.STRUCT.MOL.BIOL. V. 12 972 2005
Members (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 286 families.
1 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
70% Homology Family (1)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 209 families.
1 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
50% Homology Family (13)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 298 families.
1 2O9V Kd = 288 uM VAL PRO PRO PRO VAL PRO PRO PRO PRO SER n/a n/a
2 2J6O Kd ~ 100 uM LYS GLY PRO PRO LEU PRO ARG PRO ARG VAL n/a n/a
3 1CKA Kd = 1.9 uM PRO PRO PRO ALA LEU PRO PRO LYS LYS ARG n/a n/a
4 1FYN - PRO PRO ALA TYR PRO PRO PRO PRO VAL PRO n/a n/a
5 1ABO - ALA PRO THR MET PRO PRO PRO LEU PRO PRO n/a n/a
6 4LNP Kd = 214 uM VAL PRO PRO PRO ARG PRO PRO PRO PRO GLU n/a n/a
7 2W0Z - ALA PRO PRO PRO ARG PRO PRO LYS PRO n/a n/a
8 1YWO Kd = 12.5 uM GLN PRO PRO VAL PRO PRO GLN ARG PRO MET n/a n/a
9 2AK5 Kd = 14 uM ARG PRO PRO LYS PRO ARG PRO ARG n/a n/a
10 2SEM - ACE PRO PRO PRO VAL IPG PRO ARG ARG n/a n/a
11 3SEM - PRO PRO PRO VAL NMC PRO ARG ARG ARG n/a n/a
12 1SEM Kd = 43 uM ACE PRO PRO PRO VAL PRO PRO ARG ARG ARG n/a n/a
13 4HXJ Kd = 74.3 uM ARG GLY THR n/a n/a
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ARG PRO PRO LYS PRO ARG PRO ARG; Similar ligands found: 0
No: Ligand ECFP6 Tc MDL keys Tc
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2AK5; Ligand: ARG PRO PRO LYS PRO ARG PRO ARG; Similar sites found with APoc: 50
This union binding pocket(no: 1) in the query (biounit: 2ak5.bio1) has 11 residues
No: Leader PDB Ligand Sequence Similarity
1 2A4W BLM None
2 2VBU CDP None
3 6DO3 PRO PRO PRO MET ALA GLY GLY None
4 1CER NAD None
5 3ETH ATP None
6 3NVD OAN None
7 1YOK P6L 3.125
8 3PB9 1BN 3.125
9 6BQ6 TER 3.125
10 6MJF SAH 4.6875
11 1DQN IMU 4.6875
12 1M7G ADP 4.6875
13 1M7G ADX 4.6875
14 2PK4 ACA 4.6875
15 2WME NAP 4.6875
16 5F3I 5UJ 6.25
17 2WW4 ADP 6.25
18 1GPE FAD 6.25
19 1OJ4 ANP 6.25
20 2UVJ ADA ADA ADA 7.8125
21 3QVP FAD 7.8125
22 1COY FAD 7.8125
23 1COY AND 7.8125
24 154L NAG NAG NAG 7.8125
25 1URX AAL GAL AAL GAL AAL GAL AAL 7.8125
26 2JLD AG1 7.8125
27 5H41 BGC GLC 7.8125
28 1ON3 MCA 7.8125
29 3V1Y NAD 7.8125
30 2IMW DDS 7.8125
31 1SZD APR 9.375
32 4WZ8 3W7 9.375
33 4Z24 FAD 9.375
34 3NY4 SMX 9.375
35 3VSS FRU 10.9375
36 1H5T DAU 10.9375
37 4W93 3L9 10.9375
38 4LTN FMN 10.9375
39 4LTN NAI 10.9375
40 6GEW SFG 12.5
41 6GEW SAH 12.5
42 2NVA PL2 12.5
43 5UKL SIX 12.5
44 3VSV XYP 14.0625
45 4KBB BGC GAL SIA NGA GAL SIA 15.625
46 5EEH SAH 18.75
47 5X1M THG 20.3125
48 5X1M DHB 20.3125
49 1EOM NAG MAN MAN MAN NAG GAL NAG GAL 21.875
50 3WLE NAD 25
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