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Receptor
PDB id Resolution Class Description Source Keywords
2Z7Q 2 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF HUMAN R TO AMP-PCP HOMO SAPIENS PROTEIN KINASE; CANCER; KINASE INHIBITOR ATP-BINDING MAGNEMETAL-BINDING NUCLEOTIDE-BINDING PHOSPHORYLATION SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE N-TERMINAL KINASE DOMAIN RSK1 BOUND TO THREE DIFFERENT LIGANDS: IMPLICATIONS DESIGN OF RSK1 SPECIFIC INHIBITORS. PROTEIN SCI. V. 16 2626 2007
Ligand
Ligand Chain:Residue Validity Ligand Warnings Binding Data NGL Viewer Molecular Weight (Da) Formula SMILES
ACP A:500;
Valid;
none;
submit data
505.208 C11 H18 N5 O12 P3 c1nc(...
MG A:501;
Part of Protein;
none;
submit data
24.305 Mg [Mg+2...
View in 3D viewer
90% Homology Family
Leader
PDB id Resolution Class Description Source Keywords
2Z7R 2 Å EC: 2.7.11.1 CRYSTAL STRUCTURE OF THE N-TERMINAL KINASE DOMAIN OF HUMAN RSK1 BOUND TO STAUROSPORINE HOMO SAPIENS PROTEIN KINASE CANCER KINASE INHIBITOR ATP-BINDING MAGNESIUM METAL-BINDING NUCLEOTIDE-BINDING PHOSPHORYLATION POLYMORPHISM SERINE/THREONINE-PROTEIN KINASE TRANSFERASE
Ref.: CRYSTAL STRUCTURES OF THE N-TERMINAL KINASE DOMAIN OF HUMAN RSK1 BOUND TO THREE DIFFERENT LIGANDS: IMPLICATIONS FOR THE DESIGN OF RSK1 SPECIFIC INHIBITORS. PROTEIN SCI. V. 16 2626 2007
Members (3)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 117 families.
1 2Z7S - P01 C19 H25 Cl N6 O CC(C)[C@H]....
2 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
3 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 C[C@@]12[C....
70% Homology Family (17)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 91 families.
1 2Z7S - P01 C19 H25 Cl N6 O CC(C)[C@H]....
2 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
3 2Z7R ic50 = 3 nM STU C28 H26 N4 O3 C[C@@]12[C....
4 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
5 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
6 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
7 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
8 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
9 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
10 4EL9 - AFE C21 H20 O10 C[C@H]1[C@....
11 5D9L ic50 = 0.024 uM 583 C15 H12 N2 O2 c1cc(ccc1c....
12 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
13 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
14 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
15 3WF7 ic50 = 206 nM FS9 C18 H17 F3 N6 O c1cc(cc(c1....
16 4L3J - 5FI C19 H21 F3 N6 CCc1cncnc1....
17 3WF6 ic50 = 33 nM FZ9 C18 H16 N6 c1ccc2c(c1....
50% Homology Family (199)
No: PDB id Binding Data Representative ligand Formula Smiles
The Class containing this family consists of a total of 60 families.
1 2YM8 ic50 = 0.013 uM YM8 C19 H19 Cl N6 O C[C@H](CN(....
2 5OPU ic50 = 0.1237 uM A3K C15 H12 N4 Cc1cccc(c1....
3 5OP4 ic50 = 0.4476 uM A0T C19 H21 F4 N5 O3 CCNc1c(cnc....
4 2CGW ic50 = 17.3 uM 3C3 C9 H15 N9 O2 CCCn1c(nc(....
5 3F9N ic50 = 1.3 uM 38M C29 H35 Cl N4 O2 S CCCC[C@@H]....
6 4JIK ic50 = 0.039 uM 1KO C18 H19 Cl N6 O c1cc(ccc1c....
7 4QYH ic50 = 0.0013 uM 3DX C22 H20 N6 CN1CCN(CC1....
8 2BRB Ki = 13.7 uM PFQ C20 H17 N3 O2 c1ccc(cc1)....
9 3PA3 ic50 = 1 nM C70 C18 H18 Cl N5 O S c1cc(ccc1c....
10 5OQ6 ic50 = 0.0828 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
11 6FCF ic50 = 0.006 uM D58 C20 H22 N4 O S C[C@@H]1[C....
12 2YER ic50 = 0.02 uM TQ1 C15 H12 N4 O2 c1cc([nH]c....
13 2E9O ic50 = 20 nM A58 C25 H27 N3 O2 CC1CCC(CC1....
14 5OPB ic50 = 0.0577 uM A1N C21 H25 N5 O2 C[C@@H]1CN....
15 2WMQ - ZYQ C9 H11 N3 O2 S CC(=O)Nc1n....
16 2BRO ic50 = 1.4 uM DF2 C21 H20 N4 O2 c1ccc(cc1)....
17 2QHN ic50 = 980 nM 582 C13 H13 N3 O CCN1c2cccc....
18 4RVM ic50 = 1 nM 3X7 C23 H21 N5 c1cc(ccc1C....
19 5DLS ic50 = 4.4 nM 5CV C31 H34 N6 O3 CC(C)(CN(C....
20 3TKI ic50 = 0.05 nM S25 C20 H23 N7 O2 S c1cnc(cc1N....
21 2YM5 ic50 = 0.43 uM YM5 C18 H21 N5 O2 c1cc(cc(c1....
22 4HYH ic50 = 1 nM 1AM C22 H22 N6 O3 S COc1ccc2c(....
23 5OPV ic50 = 0.1203 uM A3H C19 H16 N6 Cc1cccc(c1....
24 5OOT ic50 = 0.0681 uM 4K4 C31 H38 N8 O3 CN1CCN(CC1....
25 1NVS Ki = 15 nM UCM C24 H15 N3 O3 c1ccc2c(c1....
26 2YDK ic50 = 0.007 uM YDK C17 H20 N4 O2 S c1ccc(cc1)....
27 3OT3 ic50 = 0.005 uM 22K C16 H20 Br N7 Cn1cc(cn1)....
28 2HXQ ic50 = 144 nM 373 C24 H26 N4 O c1ccc2c(c1....
29 2QHM ic50 = 660 nM 7CS C16 H19 N3 O2 CN1[C@H]2C....
30 2BRH ic50 = 22 uM DFW C20 H15 N3 O3 c1ccc(cc1)....
31 2R0U ic50 = 1 nM M54 C25 H22 N4 O2 c1cc(cc(c1....
32 1NVR Ki = 7.8 nM STU C28 H26 N4 O3 C[C@@]12[C....
33 3OT8 ic50 = 0.009 uM MI5 C19 H22 N8 S Cc1cc(sn1)....
34 2YM4 ic50 = 1.5 uM 4YM C21 H22 N6 O3 CCOC(=O)c1....
35 4HYI ic50 = 2 nM 1AO C21 H20 N6 O S c1ccc2c(c1....
36 4RVL ic50 = 41.7 nM 3XL C17 H10 N4 O c1ccc(c(c1....
37 5JQ5 Kd = 2341 nM I74 C22 H30 N6 O CC(C)c1cnn....
38 2C6O - 4SP C18 H22 N6 O3 S c1cc(ccc1N....
39 1V1K Ki = 35 uM 3FP C22 H23 F4 N5 O2 CN(C)C[C@H....
40 2VTJ ic50 = 1.9 uM LZ4 C10 H9 Cl N4 O2 S c1cc(ccc1N....
41 3EZV - EZV C25 H25 N7 CN1CCN(CC1....
42 3PXZ Kd = 37 uM 2AN C16 H13 N O3 S c1ccc(cc1)....
43 1W0X - OLO C15 H18 N6 O Cn1cnc2c1n....
44 2XMY Ki = 0.11 nM CDK C18 H21 N5 O4 S2 CC1=C(SC(=....
45 2UZO ic50 = 18 uM C62 C14 H10 N2 O5 S2 c1cc(ccc1c....
46 1KE7 ic50 = 8.9 nM LS3 C20 H15 N3 O4 S c1cc2c(cc1....
47 1DM2 - HMD C11 H10 Br N5 O2 C1CNC(=O)C....
48 1DI8 ic50 = 1 uM DTQ C16 H15 N3 O3 COc1cc2c(c....
49 5JQ8 - I73 C22 H30 N6 O CC(C)c1cnn....
50 1GIJ - 2PU C19 H22 N6 O2 c1cc2c(c(c....
51 2R3P ic50 = 900 nM 3SC C19 H12 Cl2 N6 S c1cc(c(c(c....
52 1KE8 ic50 = 1000 nM LS4 C18 H14 N4 O3 S2 c1ccc2c(c1....
53 2C6I ic50 = 11 uM DT1 C18 H22 N6 O3 S c1cc(ccc1N....
54 1PXP Ki ~ 0.22 uM CK8 C17 H19 N5 S Cc1c(sc(n1....
55 2UZN ic50 = 0.03 uM C96 C15 H13 N3 O4 S2 [H]/N=C/1N....
56 2B55 ic50 = 96 nM D31 C24 H31 N5 O2 c1cc-2c(c(....
57 5K4J - 6QB C21 H18 Cl F N6 O2 Cn1c(ccn1)....
58 3PJ8 - 404 C19 H26 N6 O CC[C@H](CO....
59 3LFQ - A28 C17 H15 F2 N3 O CCCC(=O)Nc....
60 2W05 ic50 = 0.001 uM FRT C20 H26 N6 O3 S Cc1ncc(n1C....
61 2XNB Ki = 149 nM Y8L C19 H22 N6 O S CC1=C(SC(=....
62 1HCK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
63 5IEX - 6AF C17 H21 Br N4 O3 S C[C@H]([C@....
64 2R3H ic50 = 20000 nM SCE C13 H13 N5 Cc1cnc2n1c....
65 4O0X Ki = 0.068 uM 2OQ C19 H20 N6 O Cc1nc2ccc(....
66 4O0Y Ki = 0.06 uM 2OO C17 H19 N7 O CCNc1nc2cc....
67 5LI9 - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
68 3A8W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
69 2F2U - M77 C14 H17 N3 O2 S c1cc2cnccc....
70 3OWL ic50 = 0.67 uM 19E C16 H11 Cl N2 O Cc1cnc(c2c....
71 5OYF - B4Q C25 H27 N3 CCc1ccccc1....
72 5H8G ic50 < 0.003 uM 5Y4 C23 H29 N9 O CC(=O)Nc1c....
73 5OS7 - A8Q C16 H19 Cl N CC(C)c1ccc....
74 5OTZ Kd = 6.5 uM AUT C15 H15 Cl2 N CCc1ccccc1....
75 5OUM - AVK C18 H18 Cl N3 c1ccc(cc1)....
76 5B0X ic50 = 0.02 uM HCK C18 H14 N2 O4 S COc1ccc(cc....
77 5MO8 Kd = 1.64 uM C98 C26 H26 Cl N3 O4 c1ccc(cc1)....
78 3R1N - 05B C22 H21 N5 O3 c1cc2c(cc1....
79 3BWJ ic50 = 2.6 uM ARX C28 H47 N15 O7 [H]/N=C(N)....
80 3AGL Ki = 16 nM A03 C37 H63 N17 O9 [H]/N=C(N)....
81 1RE8 Ki = 0.3 nM BD2 C27 H26 N2 O6 c1ccc(c(c1....
82 1SZM ic50 = 6.35 uM BI4 C27 H26 N4 O2 C[N@]1CCC[....
83 1REJ Ki = 5 nM B1L C20 H22 N2 O5 c1cc(ccc1C....
84 2Z7Q - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
85 1MQ4 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
86 5EW9 Ki < 0.01 nM 5VC C22 H21 Cl F N3 O3 S c1cc(nc(c1....
87 5ORY ic50 = 407 uM AY4 C9 H6 F2 N2 O c1c[nH]nc1....
88 4CEG - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
89 5ORV Kd = 1297 uM A65 C6 H9 N O S3 CSc1c(c(sn....
90 5OS6 - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
91 3DJ6 - AK6 C25 H24 N4 O3 S COc1ccc(cc....
92 5OSF - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
93 2WQE - ADP C10 H15 N5 O10 P2 c1nc(c2c(n....
94 6CPF - ACP C11 H18 N5 O12 P3 c1nc(c2c(n....
95 3FDN ic50 = 0.033 uM MMH C21 H22 N6 O3 Cc1c(c([nH....
96 3KXH - K66 C11 H9 Br4 N3 O2 CN(C)c1nc2....
97 4DGM ic50 = 1.2 uM AGI C15 H10 O5 c1cc(ccc1C....
98 3PVG - K68 C9 H4 Br4 N2 O2 c1nc2c(n1C....
99 1ZOG Ki = 0.07 uM K37 C8 H4 Br4 N2 S CSc1[nH]c2....
100 2PVJ Ki = 0.005 uM P44 C19 H21 N7 c1ccc(cc1)....
101 1P4F - DRG C12 H11 N3 c1ccc-2c(c....
102 4TXC Kd = 0.24 uM 38G C24 H27 N5 O3 CN(C)CCN[C....
103 2YAK ic50 = 2 nM OSV C27 H31 F N4 O3 Ru S4 CC(C)Oc1cc....
104 5AUY ic50 = 1.6 uM MRI C15 H10 O7 c1cc(c(cc1....
105 2HY0 ic50 = 0.65 nM 306 C26 H25 N5 O c1cc2c(cc1....
106 5LVO - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
107 4XX9 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
108 2XCK ic50 = 713 nM MH4 C29 H33 N9 O Cc1cc(ccn1....
109 3QD4 ic50 = 0.00000001 M 3Q6 C22 H30 N8 O2 C[C@@H]1C[....
110 3RCJ ic50 = 0.8 uM 3RC C16 H13 N5 c1ccc(cc1)....
111 2PE0 - 39Z C14 H12 N2 O2 CC(c1ccc[n....
112 4CT2 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
113 5ACK - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
114 3HRC - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
115 5LVM - ADE C5 H5 N5 c1[nH]c2c(....
116 5MRD ic50 = 36.4 uM S26 C18 H13 Cl N2 O4 S2 CCOC(=O)C1....
117 3ION ic50 = 8 nM 8H1 C28 H27 N5 O3 COc1cc2c3c....
118 1UU7 ic50 = 14 uM BI2 C27 H26 N4 O2 C[N@@]1CCC....
119 3HRF Kd = 10.3 uM P47 C17 H15 Cl O2 c1ccc(cc1)....
120 3QCS ic50 = 0.00000001 M 3Q1 C15 H17 N7 O c1cc2c(cc1....
121 1H1W - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
122 4AW1 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
123 2PE2 - 464 C28 H30 N6 O3 c1cc(cc(c1....
124 3H9O ic50 = 70 nM 9BD C19 H19 N5 O3 COCCOc1cc2....
125 3QD3 ic50 = 0.00000001 M 3Q5 C22 H30 N8 O2 C[C@H]1CC[....
126 1OKY ic50 = 6.5 nM STU C28 H26 N4 O3 C[C@@]12[C....
127 3IOP ic50 = 17 nM 8I1 C28 H27 N5 O3 COc1cc2c3c....
128 2PE1 ic50 = 6 nM 517 C15 H14 N4 O2 CC(c1ccc[n....
129 3RWP Ki = 0.6 nM ABQ C24 H24 F N7 O2 CC(C)n1cc(....
130 3NAX - MP7 C28 H22 F2 N4 O4 c1ccc(cc1)....
131 3QCQ ic50 = 0.00000001 M 3Q0 C13 H15 N7 CCNc1cc(nc....
132 4A06 - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
133 2R5T - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
134 2JDO ic50 = 0.23 uM I5S C20 H22 Cl N3 O3 S c1cc2cnccc....
135 1O6K - GLY ARG PRO ARG THR THR SER PHE ALA GLU n/a n/a
136 3E88 Ki = 2 nM G96 C24 H27 N7 O3 CCn1c2cc(n....
137 2UW9 - GVP C20 H20 Cl N3 c1cc(ccc1c....
138 2JDR ic50 = 0.5 nM L20 C24 H23 N5 O Cc1c2cc(cc....
139 3D0E ic50 = 13 nM G93 C21 H27 N7 O3 CCn1c2c(cn....
140 4QMX ic50 = 11 uM H8H C27 H32 Cl N5 O5 CN1CCN(CC1....
141 4QMT ic50 = 0.01 uM H1N C29 H32 N4 O3 S CCS(=O)(=O....
142 4QMM ic50 = 0.46 uM 35R C19 H23 N7 O2 c1cc2c(cc1....
143 4QMU ic50 = 1.3 uM SKE C15 H12 F2 N6 O3 S c1cc(c(c(c....
144 4W8E - 3JB C20 H17 N7 O2 Cc1nc(no1)....
145 4QMZ ic50 = 0.21 uM B49 C22 H27 F N4 O2 CCN(CC)CCN....
146 3UBD Kd = 2.9 uM SL0 C25 H24 O12 CC1C(C(C(C....
147 4GUE Kd = 5.8 uM QCT C21 H20 O11 C[C@H]1[C@....
148 3G51 - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
149 4NUS ic50 = 0.005 uM 2NK C22 H21 F2 N3 O CN1CCN(CC1....
150 4NW6 ic50 = 0.004 uM 2NS C23 H20 N4 O4 COc1cc(cc(....
151 4NW5 ic50 = 0.02 uM 2NR C23 H21 F N2 O5 COc1cccc(c....
152 1U5R - ATP C10 H16 N5 O13 P3 c1nc(c2c(n....
153 2W7X ic50 = 138 nM D1A C18 H17 N7 O3 [H]/N=C(N)....
154 4A9U - A9U C27 H28 N4 O2 c1ccc(cc1)....
155 2YCF ic50 = 0.7 nM YCF C19 H24 N10 O3 [H]/N=C(N/....
156 4BDI ic50 = 227.7 uM HAU C14 H19 N3 O2 Cc1ccc(nc1....
157 2YCR ic50 = 69.6 nM HCW C23 H28 N10 O C/C(=NNC1=....
158 2WTJ ic50 = 0.7 uM WTJ C16 H20 N4 O3 S CN(C)CCNC(....
159 4BDB ic50 = 85.6 uM ODO C8 H9 N O3 C/C(=NO)/c....
160 2YIT ic50 = 0.29 nM YIT C21 H24 N6 O2 CCC/C(=NNC....
161 2W0J ic50 = 240 nM ZAT C19 H24 N10 O [H]/N=C(N)....
162 6CCY ic50 = 0.003 uM EX4 C29 H33 F4 N7 O C[C@@H]1CC....
163 3QKK - SMH C28 H38 N2 O7 S CCOCCN(C[C....
164 4EKL ic50 = 5 nM 0RF C24 H32 Cl N5 O2 C[C@@H]1C[....
165 3CQW ic50 = 42 nM CQW C12 H11 Cl N6 c1c(c2c([n....
166 4GV1 ic50 = 3 nM 0XZ C21 H25 Cl N6 O2 c1cc(ccc1[....
167 3MVH ic50 = 0.5 nM WFE C20 H22 F2 N6 O CCc1c[nH]c....
168 3MV5 ic50 = 180 nM XFE C11 H15 N5 Cc1c[nH]c2....
169 3QKL - SMR C29 H40 N4 O5 S CCOCC[N@@]....
170 5DH3 ic50 = 38.1 nM 5BS C17 H16 N6 O3 S2 CN1c2ccsc2....
171 5OTF - AQ5 C20 H24 N6 c1cnc2c(c1....
172 3TKU ic50 = 1.92 uM M77 C14 H17 N3 O2 S c1cc2cnccc....
173 3V8S ic50 = 0.65 uM 0HD C16 H16 N4 O c1ccc(cc1)....
174 4OTH ic50 = 9 nM DRN C25 H23 N5 O2 S [H]/N=C(/N....
175 5OOI - 9YE C23 H25 N O3 CC(C)n1c2c....
176 6CQF ic50 = 0.0045 uM F97 C21 H26 F2 N8 CC(C)n1c2c....
177 3A62 - STU C28 H26 N4 O3 C[C@@]12[C....
178 3WF9 ic50 = 567 nM FS7 C24 H25 N3 O5 S C[C@H]1CCc....
179 3WF8 ic50 = 232 nM F76 C23 H23 N3 O5 S c1ccc2c(c1....
180 4L3L - 5FI C19 H21 F3 N6 CCc1cncnc1....
181 3WE4 ic50 = 15 nM 5FI C19 H21 F3 N6 CCc1cncnc1....
182 3WF5 ic50 = 81 nM FZ8 C17 H17 N7 c1ccc2c(c1....
183 3FY0 ic50 = 1090 nM DW1 C23 H13 N3 O4 Ru C1=CC(C=C1....
184 4EQU - G6I C30 H24 F3 N7 O2 Cc1ccc(cc1....
185 4OBQ ic50 = 0.065 uM 2QT C20 H20 F N5 O c1cc2c(cc1....
186 4U43 Kd = 48 uM 3D8 C11 H9 N5 c1cc(cnc1)....
187 4OBP ic50 = 0.017 uM 2QU C12 H8 F N5 c1cc(nc2c1....
188 6C0T ic50 = 43 nM EE4 C30 H30 F N5 O5 CCCOc1ccc(....
189 6BXI - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
190 3DV3 - MEK C18 H18 F3 I N2 O5 c1cc(c(cc1....
191 3EQD - AGS C10 H16 N5 O12 P3 S c1nc(c2c(n....
192 5F9E ic50 = 0.46 nM 5VS C23 H21 N5 O2 CC1(NC(=O)....
193 1XJD Ki = 0.33 nM STU C28 H26 N4 O3 C[C@@]12[C....
194 5DBX - ANP C10 H17 N6 O12 P3 c1nc(c2c(n....
195 3TXO ic50 = 9 nM 07U C17 H19 N5 CC(C)(CNc1....
196 4USF - 6UI C19 H15 N3 O COc1ccc2cc....
197 2J51 - DKI C15 H13 F2 N7 O2 S2 c1cc(c(c(c....
198 1V0P ic50 = 0.13 uM PVB C20 H25 Cl N6 O3 CC(C)[C@H]....
199 1V0O ic50 = 5.5 uM INR C16 H10 N2 O5 S c1ccc2c(c1....
Polypharmacology
Similar Ligands
Ligand no: 1; Ligand: ACP; Similar ligands found: 368
No: Ligand ECFP6 Tc MDL keys Tc
1 ACP 1 1
2 ACQ 0.866667 1
3 A2D 0.857143 0.945205
4 6YZ 0.833333 1
5 BA3 0.833333 0.945205
6 AP5 0.821918 0.945205
7 B4P 0.821918 0.945205
8 ADP 0.821918 0.972222
9 AT4 0.810811 0.933333
10 AN2 0.810811 0.958904
11 AP2 0.808219 0.986301
12 A12 0.808219 0.986301
13 M33 0.8 0.932432
14 HEJ 0.789474 0.972222
15 ATP 0.789474 0.972222
16 5FA 0.779221 0.972222
17 AR6 0.779221 0.945205
18 AQP 0.779221 0.972222
19 APR 0.779221 0.945205
20 AGS 0.769231 0.921053
21 SAP 0.769231 0.921053
22 AD9 0.769231 0.945946
23 AMP 0.763889 0.944444
24 A 0.763889 0.944444
25 APC 0.75641 0.986301
26 CA0 0.753247 0.92
27 ADX 0.753247 0.851852
28 ANP 0.75 0.945946
29 50T 0.74359 0.932432
30 PRX 0.734177 0.87013
31 ABM 0.733333 0.893333
32 ATF 0.731707 0.933333
33 SRA 0.706667 0.894737
34 A22 0.705882 0.958904
35 RBY 0.703704 0.959459
36 ADV 0.703704 0.959459
37 5AL 0.698795 0.906667
38 A3R 0.689655 0.909091
39 A1R 0.689655 0.909091
40 ADQ 0.689655 0.92
41 AU1 0.6875 0.945946
42 TAT 0.686747 0.933333
43 T99 0.686747 0.933333
44 SRP 0.682353 0.907895
45 9X8 0.674157 0.896104
46 OAD 0.674157 0.92
47 4TC 0.673469 0.922078
48 4AD 0.670455 0.921053
49 AMO 0.670455 0.933333
50 00A 0.662921 0.860759
51 ADP PO3 0.662651 0.917808
52 3OD 0.659341 0.92
53 BIS 0.659341 0.909091
54 25A 0.659091 0.945205
55 OOB 0.659091 0.906667
56 8QN 0.659091 0.906667
57 5SV 0.659091 0.82716
58 SON 0.654321 0.933333
59 25L 0.652174 0.958904
60 PAJ 0.651685 0.8625
61 DLL 0.644444 0.906667
62 AHX 0.644444 0.897436
63 TXA 0.641304 0.907895
64 3UK 0.637363 0.894737
65 ALF ADP 0.632184 0.848101
66 ADP ALF 0.632184 0.848101
67 PR8 0.630435 0.851852
68 WAQ 0.630435 0.884615
69 B5V 0.630435 0.883117
70 LAD 0.630435 0.8625
71 MAP 0.629214 0.921053
72 LMS 0.628205 0.807229
73 GAP 0.627907 0.87013
74 VO4 ADP 0.625 0.906667
75 ADP VO4 0.625 0.906667
76 PTJ 0.623656 0.873418
77 FYA 0.623656 0.906667
78 ME8 0.623656 0.841463
79 1ZZ 0.623656 0.819277
80 NB8 0.623656 0.897436
81 UP5 0.62 0.896104
82 G3A 0.618557 0.897436
83 G5P 0.612245 0.897436
84 AFH 0.612245 0.886076
85 9SN 0.610526 0.85
86 DQV 0.606061 0.932432
87 GTA 0.606061 0.864198
88 9ZD 0.604396 0.884615
89 9ZA 0.604396 0.884615
90 YAP 0.604167 0.896104
91 FA5 0.604167 0.907895
92 B5Y 0.604167 0.871795
93 B5M 0.604167 0.871795
94 TXD 0.60396 0.884615
95 XAH 0.597938 0.841463
96 ADN 0.597222 0.821918
97 RAB 0.597222 0.821918
98 XYA 0.597222 0.821918
99 GA7 0.59596 0.907895
100 48N 0.594059 0.897436
101 DAL AMP 0.593407 0.881579
102 2A5 0.593023 0.92
103 AOC 0.592593 0.8
104 4UV 0.591837 0.871795
105 NXX 0.588235 0.907895
106 6V0 0.588235 0.873418
107 NAX 0.588235 0.875
108 DND 0.588235 0.907895
109 NAI 0.588235 0.884615
110 ATR 0.586207 0.944444
111 PAP 0.586207 0.958333
112 ADP BMA 0.585106 0.894737
113 LAQ 0.584158 0.819277
114 5AS 0.583333 0.761364
115 OMR 0.582524 0.831325
116 TXE 0.582524 0.884615
117 5N5 0.581081 0.797297
118 4UU 0.58 0.871795
119 A A 0.578947 0.918919
120 7D3 0.578313 0.881579
121 AP0 0.576923 0.873418
122 A4D 0.573333 0.797297
123 5CD 0.573333 0.783784
124 JB6 0.572917 0.884615
125 4UW 0.572816 0.839506
126 A4P 0.571429 0.823529
127 CNA 0.570093 0.907895
128 ITT 0.569767 0.917808
129 7D4 0.569767 0.881579
130 A2R 0.565217 0.958904
131 M2T 0.564103 0.716049
132 YLP 0.563107 0.821429
133 139 0.560748 0.851852
134 ADJ 0.560748 0.831325
135 T5A 0.560748 0.843373
136 TAD 0.558824 0.910256
137 ATP A A A 0.555556 0.905405
138 A3P 0.552941 0.944444
139 TYM 0.552381 0.907895
140 IOT 0.551402 0.833333
141 EP4 0.551282 0.734177
142 MYR AMP 0.55102 0.797619
143 F2R 0.550459 0.865854
144 7D5 0.55 0.855263
145 A3D 0.54955 0.894737
146 80F 0.54955 0.843373
147 GCP 0.548387 0.922078
148 UPA 0.54717 0.884615
149 YLC 0.54717 0.841463
150 YLB 0.54717 0.821429
151 NAD 0.545455 0.906667
152 COD 0.545455 0.813953
153 G5A 0.544444 0.781609
154 HFD 0.544444 0.921053
155 DTA 0.544304 0.766234
156 3DH 0.54321 0.753247
157 DZD 0.540541 0.910256
158 AHZ 0.538462 0.797619
159 MTA 0.5375 0.753247
160 3AM 0.536585 0.90411
161 A2P 0.534884 0.930556
162 AR6 AR6 0.533981 0.893333
163 PPS 0.532609 0.851852
164 6AD 0.532609 0.886076
165 YLA 0.53211 0.821429
166 TYR AMP 0.529412 0.871795
167 AMP DBH 0.529412 0.87013
168 AYB 0.527273 0.811765
169 A5A 0.526882 0.788235
170 TSB 0.526316 0.8
171 6RE 0.52381 0.7625
172 S4M 0.523256 0.670455
173 SSA 0.521277 0.802326
174 NA7 0.520408 0.959459
175 7MD 0.519231 0.864198
176 ARG AMP 0.519231 0.831325
177 LPA AMP 0.518868 0.797619
178 BTX 0.517857 0.843373
179 NAE 0.517241 0.871795
180 54H 0.515789 0.770115
181 52H 0.515789 0.761364
182 VMS 0.515789 0.770115
183 BT5 0.513274 0.833333
184 NAQ 0.512821 0.85
185 ZAS 0.511905 0.746835
186 J7C 0.511628 0.772152
187 A3N 0.511628 0.766234
188 IMO 0.511628 0.90411
189 AV2 0.510638 0.893333
190 53H 0.510417 0.761364
191 8X1 0.510417 0.755556
192 5CA 0.510417 0.802326
193 ARU 0.510204 0.839506
194 AF3 ADP 3PG 0.509259 0.839506
195 M24 0.508621 0.829268
196 ZID 0.508475 0.894737
197 2AM 0.506024 0.917808
198 V3L 0.505376 0.945205
199 3AT 0.505376 0.972222
200 AVV 0.505155 0.897436
201 NSS 0.5 0.802326
202 EAD 0.5 0.851852
203 DSZ 0.5 0.802326
204 MAO 0.5 0.761905
205 LSS 0.5 0.764045
206 DSH 0.5 0.728395
207 P5A 0.5 0.747253
208 YLY 0.495726 0.811765
209 9K8 0.49505 0.698925
210 NVA LMS 0.494949 0.755556
211 DAT 0.494505 0.906667
212 5X8 0.494505 0.766234
213 AMP NAD 0.491228 0.881579
214 7MC 0.490909 0.843373
215 LEU LMS 0.49 0.755556
216 SMM 0.489583 0.689655
217 SAM 0.489362 0.694118
218 DTP 0.489362 0.906667
219 7DD 0.488889 0.958333
220 GJV 0.488636 0.753086
221 OVE 0.488372 0.881579
222 5AD 0.486842 0.726027
223 GSU 0.485149 0.781609
224 KAA 0.485149 0.755556
225 P1H 0.483871 0.831325
226 NDE 0.483871 0.907895
227 N0B 0.483333 0.821429
228 A3G 0.482759 0.802632
229 NAJ PZO 0.478632 0.82716
230 4TA 0.478261 0.809524
231 SFG 0.478261 0.753247
232 NDC 0.47619 0.85
233 YSA 0.47619 0.781609
234 FB0 0.47619 0.827586
235 7DT 0.473118 0.958333
236 A7D 0.472527 0.779221
237 NJP 0.469565 0.921053
238 FDA 0.46875 0.835294
239 SA8 0.468085 0.710843
240 A5D 0.468085 0.766234
241 MHZ 0.467391 0.701149
242 8PZ 0.466667 0.802326
243 71V 0.466667 0.884615
244 G A A A 0.465517 0.85
245 0WD 0.465517 0.897436
246 6FA 0.465116 0.843373
247 GGZ 0.464646 0.804878
248 SAI 0.463158 0.7375
249 SAH 0.463158 0.746835
250 6C6 0.463158 0.883117
251 NAJ PYZ 0.46281 0.788235
252 Y3J 0.4625 0.706667
253 7D7 0.461538 0.723684
254 TXP 0.46087 0.897436
255 PO4 PO4 A A A A PO4 0.460784 0.878378
256 S7M 0.459184 0.694118
257 6IA 0.458333 0.839506
258 DDS 0.458333 0.855263
259 FAS 0.458015 0.853659
260 FAD 0.458015 0.853659
261 SFD 0.458015 0.736842
262 ODP 0.456897 0.886076
263 A3S 0.456522 0.813333
264 U A 0.453782 0.884615
265 7C5 0.453704 0.797468
266 EEM 0.453608 0.694118
267 AAT 0.453608 0.710843
268 A G 0.452991 0.860759
269 RGT 0.45283 0.933333
270 NPW 0.452174 0.8875
271 NDP 0.452174 0.897436
272 FAY 0.451852 0.864198
273 PGS 0.451613 0.860759
274 D5M 0.449438 0.88
275 DA 0.449438 0.88
276 NEC 0.449438 0.727273
277 U A G G 0.449153 0.860759
278 2SA 0.44898 0.933333
279 NIA 0.448276 0.802469
280 NZQ 0.448276 0.910256
281 A U 0.447368 0.848101
282 A3T 0.446809 0.8
283 A A A 0.446602 0.906667
284 128 0.446429 0.758621
285 6K6 0.445545 0.905405
286 GEK 0.445545 0.740741
287 4YB 0.445455 0.764045
288 AAM 0.444444 0.944444
289 FNK 0.444444 0.806818
290 62F 0.444444 0.864198
291 Z5A 0.443548 0.761364
292 WSA 0.442478 0.790698
293 AMZ 0.44186 0.891892
294 C2R 0.44186 0.88
295 12D 0.441441 0.767442
296 XNP 0.440678 0.851852
297 RFL 0.437956 0.823529
298 62X 0.436893 0.670455
299 N6P 0.436893 0.890411
300 AIR 0.433735 0.876712
301 GP3 0.43299 0.897436
302 A6D 0.432692 0.705882
303 V1N 0.431193 0.893333
304 649 0.429825 0.747253
305 GP2 0.428571 0.910256
306 GDP 0.428571 0.896104
307 NA0 0.428571 0.907895
308 0UM 0.427184 0.702381
309 ETB 0.42623 0.835294
310 DCA 0.42623 0.825581
311 8Q2 0.426087 0.775281
312 9JJ 0.425532 0.841463
313 GNH 0.424242 0.884615
314 NAP 0.424 0.92
315 PUA 0.422764 0.8625
316 APU 0.422414 0.871795
317 101 0.422222 0.855263
318 3AD 0.421687 0.808219
319 FA9 0.42069 0.865854
320 TAP 0.420635 0.884615
321 TM1 0.420561 0.755814
322 P5F 0.41958 0.825581
323 0T1 0.419355 0.825581
324 COA 0.419355 0.825581
325 K15 0.419048 0.686047
326 7RP 0.417582 0.902778
327 S8M 0.417476 0.7625
328 NHD 0.416667 0.881579
329 GTP 0.415842 0.896104
330 FCX 0.414062 0.797753
331 F2N 0.413793 0.816092
332 AS 0.413043 0.835443
333 7RA 0.413043 0.931507
334 G1R 0.411765 0.884615
335 SXZ 0.411215 0.714286
336 ACK 0.411111 0.837838
337 QQY 0.411111 0.794872
338 CAO 0.409449 0.797753
339 COS 0.409449 0.806818
340 DG1 0.409449 0.897436
341 30N 0.409449 0.755319
342 AMX 0.409449 0.835294
343 1DG 0.409449 0.897436
344 J7V 0.409449 0.813953
345 EO7 0.408602 0.770115
346 8BR 0.408602 0.883117
347 NVA 2AD 0.408163 0.7625
348 D3Y 0.407767 0.792208
349 GSP 0.407767 0.851852
350 9GM 0.407767 0.873418
351 GNP 0.407767 0.873418
352 G2P 0.407767 0.910256
353 CC5 0.407407 0.819444
354 KB1 0.407407 0.702381
355 N01 0.406504 0.881579
356 A C A C 0.406504 0.82716
357 SCO 0.40625 0.825581
358 CMX 0.40625 0.825581
359 HDV 0.405941 0.87013
360 CMP 0.404255 0.876712
361 2BA 0.404255 0.890411
362 ACO 0.403101 0.797753
363 FAM 0.403101 0.806818
364 2VA 0.402062 0.779221
365 3NZ 0.401869 0.78481
366 HAX 0.4 0.806818
367 QQX 0.4 0.78481
368 26A 0.4 0.74359
Similar Binding Sites (Proteins are less than 50% similar to leader)
Pocket No.: 1; Query (leader) PDB : 2Z7R; Ligand: STU; Similar sites found with APoc: 434
This union binding pocket(no: 1) in the query (biounit: 2z7r.bio1) has 23 residues
No: Leader PDB Ligand Sequence Similarity
1 1NBU PH2 None
2 1UI0 URA 0.97561
3 4P25 FUC GAL NAG FUC 0.993378
4 5T96 79J 1.24611
5 1OX5 1PR 1.24611
6 3W0O ADP 1.55763
7 3W0O HY0 1.55763
8 5FCF GLY GLY GLY 1.55763
9 2GQR ADP 1.68776
10 2GQS ADP 1.68776
11 2GQS C2R 1.68776
12 4Z4P SAH 1.80723
13 1RZM E4P 1.86916
14 1LDN FBP 1.89873
15 4DDY DN6 1.90114
16 4IRX INS 2.02703
17 3P7G MAN 2.05479
18 3VOT ADP 2.18069
19 3TII ANP 2.18069
20 1EHI ADP 2.18069
21 4OCJ NDG 2.18069
22 3TY5 ADP 2.18069
23 6EAC ANP 2.18069
24 5OLK DTP 2.18069
25 2IF8 ADP 2.49221
26 4PZ6 GMP 2.49221
27 5VLQ ANP 2.49221
28 3ETH ATP 2.49221
29 5COU ATP 2.49221
30 2B56 U5P 2.49221
31 2R7K ACP 2.49221
32 2R7K AMZ 2.49221
33 5TT6 ATP 2.49221
34 2Q7D ANP 2.49221
35 6F5W KG1 2.49221
36 3SAO NKN 2.5
37 5HCF BGC 2.58303
38 5IGI ZIT 2.65781
39 5IGI GMP 2.65781
40 2ZL7 FUC GAL NGA 2.71186
41 2IO8 ADP 2.80374
42 3V4S ATP 2.80374
43 1E4E ADP 2.80374
44 1YVZ JPC 2.80374
45 3V4S ADP 2.80374
46 2Z49 AMG 2.80374
47 5EXK 5AD 2.80374
48 4XGX ADP 2.80374
49 4O4F ATP 2.82258
50 4O4F IHP 2.82258
51 4CC6 L5Y 2.83019
52 5ZCT ANP 2.94118
53 1IOW ADP 2.94118
54 1IOW PHY 2.94118
55 2O66 FLC 2.96296
56 5EW0 3C7 2.99145
57 3E3U NVC 3.04569
58 4OCV ANP 3.11526
59 5EQY 5RA 3.11526
60 3WVR AMP 3.11526
61 2V58 LZJ 3.11526
62 5K8P 6R8 3.11526
63 2QS8 MET 3.11526
64 6GN6 GLC 3.11526
65 3UN3 G16 3.11526
66 4WOE 3S5 3.11526
67 5Z21 OXM 3.11526
68 5NC1 NAG 3.37553
69 4MV1 ADP 3.4188
70 3TM0 ANP 3.42205
71 3TM0 B31 3.42205
72 3UDZ ADP 3.42679
73 2QK4 ATP 3.42679
74 6ARJ SAH 3.42679
75 5I34 GDP 3.42679
76 3VKX T3 3.44828
77 5C8W PCG 3.4965
78 3VZS NAP 3.50195
79 3TDV GDP 3.59477
80 5GZ9 ANP 3.60656
81 5GZ9 MAN 3.60656
82 1S68 AMP 3.61446
83 5MW8 ATP 3.73832
84 4R78 AMP 3.73832
85 3X01 AMP 3.73832
86 5C4L 4XR 3.73832
87 4DFU QUE 3.73832
88 4PU5 ANP 3.73832
89 3DNT ATP 3.73832
90 2G50 PYR 3.73832
91 2YW2 ATP 3.73832
92 3K5I ADP 3.73832
93 3OBT SLB 3.73832
94 5C4L SIS 3.73832
95 5WS9 OXL 3.73832
96 2XN3 ID8 3.73832
97 3K5I AIR 3.73832
98 3F3E LEU 3.73832
99 1QMG DMV 3.73832
100 2QX0 PH2 3.77358
101 1TD2 PXL 3.83275
102 1I06 TZL 3.88889
103 3VPD ANP 3.91459
104 1IA9 ANP 3.92857
105 2YRX AMP 3.99113
106 1TZD ADP 4
107 5OES ADP 4.04984
108 3KAL ADP 4.04984
109 3UG4 AHR 4.04984
110 2HGS ADP 4.04984
111 3PH4 AOS 4.14201
112 1W2D ADP 4.15094
113 1W2D 4IP 4.15094
114 4RDL FUC GAL NDG FUC 4.22078
115 4CS9 AMP 4.2328
116 2C6Q NDP 4.2735
117 2PUL ACP 4.36137
118 1VRP IOM 4.36137
119 1CKM GTP 4.36137
120 3BEO UDP 4.36137
121 6A5K SAM 4.36137
122 4M0R 644 4.36137
123 2OVD DAO 4.3956
124 3KA2 2NC 4.4335
125 3FSM 2NC 4.4335
126 4JLS 3ZE 4.60526
127 3HQP OXL 4.6729
128 4GN8 ASO 4.68227
129 5ML3 DL3 4.69799
130 3HEE R5P 4.69799
131 3PDT ADP 4.72727
132 1GSA ADP 4.74684
133 1VKF CIT 4.78723
134 4B1L FRU 4.84848
135 5JSP DQY 4.97512
136 1PK8 ATP 4.98442
137 4XZ3 ACP 4.98442
138 4XYM A12 4.98442
139 3ZS7 ATP 5
140 4C5N ACP 5.07246
141 4C5N PXL 5.07246
142 1XRO LEU 5.11945
143 1AUX AGS 5.14469
144 3BP1 GUN 5.17241
145 5C1P ADP 5.22876
146 5C1P DAL DAL 5.22876
147 5VZ0 ADP 5.29595
148 4LH7 1X8 5.29595
149 1KJ8 GAR 5.29595
150 1KJ8 ATP 5.29595
151 5DNC ASN 5.29595
152 3WXL ADP 5.29595
153 2BKK ADP 5.32544
154 6E8I PTR 5.32544
155 1UYY BGC BGC 5.34351
156 4PU6 ASP 5.34351
157 3PAK MAN 5.40541
158 4YMU ARG 5.45455
159 2ET1 GLV 5.47264
160 2PYW ADP 5.60748
161 5DZT AMP 5.60748
162 5IM3 DTP 5.60748
163 2XN2 GLA 5.60748
164 1GPM AMP 5.60748
165 3VP6 HLD 5.60748
166 3A76 SPD 5.68182
167 4GNC ASO 5.68562
168 3ZW2 NAG GAL FUC 5.74713
169 2VQD AP2 5.81897
170 2CFM AMP 5.919
171 4NZN 2OU 5.919
172 4NZN ANP 5.919
173 1NY5 ADP 5.919
174 5CGE 51F 6.13718
175 1I7L ATP 6.14887
176 5FS0 5JC 6.16114
177 4OIT BMA 6.19469
178 4U98 ACP 6.23053
179 6C1S EFV 6.23053
180 3ORQ ADP 6.23053
181 5TDF ADP 6.23053
182 2YFO GAL 6.23053
183 2YFO GLA 6.23053
184 4AGS GSH 6.23053
185 1RGE 2GP 6.25
186 5H4S RAM 6.33803
187 3QPB URA 6.38298
188 2XOC ADP 6.51341
189 4GYI ADP 6.54206
190 1Z2P I3S 6.54206
191 1Z2P ACP 6.54206
192 1T36 ADP 6.54206
193 1TQP ATP 6.73759
194 3VPB ADP 6.73759
195 3VPC ADP 6.73759
196 4ZGP ADP 6.82594
197 5YK1 ANP 6.85358
198 3WO0 ADP 6.85358
199 3WO0 ALA 6.85358
200 6BU0 IHP 6.87023
201 1CBK ROI 6.875
202 3ZJX BOG 6.92042
203 2PHN GDP 7.08661
204 4YZ5 SLT 7.16511
205 3K0T BGC 7.16511
206 2UV4 AMP 7.23684
207 4AF5 CIT 7.36842
208 3KIF GDL 7.54717
209 4UWH JXM 8.09969
210 5MRH Q9Z 8.09969
211 4GLW 0XT 8.19672
212 4O1P ANP 8.41121
213 3PN1 IVH 8.49057
214 5ECP ATP 8.52018
215 4XMF HSM 8.69565
216 4IX4 ADP 8.72274
217 2VPQ ANP 8.72274
218 2PYY GLU 8.77193
219 4ZS4 ATP 8.79479
220 2AQX ATP 8.99654
221 3WIR BGC 9.03427
222 4Y30 49L 9.03427
223 4Y30 SAH 9.03427
224 1OBD ATP 9.15033
225 1ZTH ADP 9.30233
226 1ZP9 ATP 9.30233
227 5FI4 5XV 9.34579
228 6CGD AKN 9.5082
229 6CGD GNP 9.5082
230 5IH1 6BQ 9.60265
231 5IH1 GDP 9.60265
232 1M0W ANP 9.65732
233 1U6R IOM 9.65732
234 3I0O ADP 9.96885
235 5AE9 OKO 9.96885
236 6G9I CXX 10.119
237 6DW2 HD4 10.1266
238 4CIB 7UZ 10.2804
239 3LQV ADE 10.4348
240 3I7V ATP 10.4478
241 6FMC DUE 10.7595
242 3LXI CAM 10.9034
243 3DGY 2GP 11.3402
244 5KBE IPH 11.3537
245 4OAV ACP 11.5265
246 4AZW ATP 11.5265
247 4RYV ZEA 11.6129
248 4Q5H ANP 11.8421
249 6E2B PT7 11.8421
250 6FL8 TIY 12.1495
251 6FL8 ADP 12.1495
252 3QDK QDK 12.7726
253 2O2C G6Q 12.7726
254 5I35 ANP 13.0841
255 4CYI ATP 14.0187
256 1IDA 0PO 14.1414
257 4YHQ G10 14.1414
258 2VFK AMP 14.6341
259 4FE2 ADP 14.902
260 4WW7 AMP 16.4751
261 5LXT ACP 17.4825
262 5K2M ADP 18.8679
263 5C03 AGS 23.053
264 1VJY 460 23.1023
265 4WOV 3SM 23.3438
266 1P6O HPY 24.2236
267 6ES0 BW8 24.6106
268 3VHE 42Q 25.2336
269 5CKW ANP 26.4798
270 3HAV ATP 28.0936
271 4YZC STU 28.3489
272 5LPZ ADP 28.972
273 1U5R ATP 29.9065
274 5T8O 76Z 29.9065
275 4IDT T28 30.2181
276 2GOO NDG 30.3922
277 5MY8 RXZ 30.5296
278 5KO1 6UY 30.7421
279 2H92 C5P 31.0502
280 5LPB ADP 31.0811
281 2QLU ADE 31.5287
282 3H9R TAK 31.7757
283 4H3P ANP 32.0872
284 4H3Q ANP 32.0872
285 4XH0 ADP 32.0872
286 4BTK DTQ 32.0872
287 6GIN IR2 32.2259
288 3LXN MI1 32.3899
289 3GNI ATP 32.3988
290 6FYL 3NG 32.7103
291 3LXK MI1 33.0218
292 2WU6 DKI 33.0218
293 3UIM ANP 33.3333
294 6GWR FEW 33.6508
295 2CSN CKI 33.67
296 5QIN J2V 33.8608
297 5EFQ ADP 34.2679
298 3GC0 AMP 34.5794
299 4CRL C1I 34.5794
300 4Y85 499 34.5794
301 3PTG 932 34.891
302 4NST ADP 34.891
303 5X8I SQZ 34.891
304 6G33 5ID 34.891
305 5AWM ANP 34.891
306 3TTI KBI 34.891
307 4WHZ 3NL 34.891
308 5Y86 HRM 35.514
309 5WNL STU 35.8255
310 3HMO STU 35.8255
311 4FL3 ANP 35.8255
312 3ALN ANP 35.8255
313 3E8N ATP 35.8255
314 3E8N VRA 35.8255
315 2B9J ADP 36.4486
316 2B9I ADP 36.4486
317 2H8H H8H 36.4486
318 2B9H ADP 36.4486
319 5ZTN CUR 36.4486
320 1Y57 MPZ 36.4486
321 5MJA 7O3 36.7213
322 6GU6 1QK 36.755
323 5HQ0 LZ9 36.755
324 4GJ3 0XP 36.755
325 6FYV 3NG 36.7601
326 3C1X CKK 36.7601
327 4CLI 5P8 36.7601
328 1JPA ANP 36.859
329 5N87 N66 37.0607
330 3GC8 B45 37.0717
331 5EKO N17 37.0717
332 2B9F ADP 37.3832
333 6GQM F8H 37.3832
334 4QMN DB8 37.4194
335 4IZY 1J2 37.6947
336 2XVD AS6 37.7483
337 4U0I 0LI 37.7778
338 4UX9 ANP 38.0062
339 1O9U ADZ 38.0062
340 3F7Z 34O 38.0062
341 4UXL 5P8 38.3178
342 4FF8 14S 38.3178
343 4E1Z 0MX 38.488
344 2Y6O 1N1 38.488
345 1BYG STU 38.4892
346 5EOB 5QQ 38.558
347 4BHN BH9 38.6293
348 3VRY B43 38.6293
349 3KMW ATP 38.7454
350 5USZ SKE 38.7543
351 2BPM 529 38.835
352 3PP0 03Q 38.9408
353 3E7O 35F 38.9408
354 4CFU 2WC 38.9439
355 4KBA 1QM 38.9728
356 6GUE FB8 39.0728
357 4BCQ TJF 39.2027
358 4BCM T7Z 39.2027
359 1V0O INR 39.2361
360 4BCN T9N 39.3333
361 5JGA 6KC 39.3651
362 5HES 032 39.4137
363 4YMJ 4EJ 39.4737
364 5LMK 6ZK 39.7306
365 1IR3 ANP 39.8693
366 3BU5 ATP 39.8693
367 2F57 23D 39.8754
368 3KRL KRL 39.8754
369 1OPK P16 39.8754
370 4P5Z Q7M 39.8754
371 5HCY 60D 39.8754
372 2XMY CDK 39.9329
373 2OO8 RAJ 40.0631
374 3EKK GS2 40.0651
375 3NW7 LGV 40.0651
376 4NM5 ADP 40.1869
377 3ZRM ZRM 40.1869
378 2JLD AG1 40.1869
379 5U6C 7YS 40.3175
380 5CEO 50D 40.3333
381 4AT3 LTI 40.4682
382 1CM8 ANP 40.4984
383 4ASE AV9 40.4984
384 5NKB 8ZT 40.5229
385 4Y93 746 40.81
386 5OKT 9XK 41.0828
387 1OUK 084 41.1215
388 2WEL K88 41.1215
389 4AG8 AXI 41.1392
390 5TA6 79D 41.433
391 3FC2 IBI 41.433
392 4LOO SB4 41.433
393 5BVE 4VG 41.433
394 3G5D 1N1 41.6084
395 5DBX ANP 41.7445
396 5JKG 6LF 41.8006
397 5JFS 6K0 41.8831
398 6E2O S0L 42.0339
399 6A1G 9OL 42.0561
400 2A19 ANP 42.2535
401 2PVF ACP 42.3676
402 3GQI ACP 42.3676
403 4EWH T77 43.2727
404 4K33 ACP 43.3022
405 3RI1 3RH 43.4505
406 3BZ3 YAM 43.4783
407 4QTB 38Z 43.6137
408 4E93 GUI 43.6137
409 3PLS ANP 43.6242
410 2X2M X2M 43.6306
411 3SLS ANP 43.75
412 5TO8 7FM 43.9716
413 5UR1 YY9 44.0514
414 5EH0 5NW 44.186
415 1ZY5 ANP 44.2244
416 5WO4 B7V 44.3709
417 1U59 STU 44.5993
418 3SXS PP2 44.7761
419 5H2U 1N1 44.9438
420 6C7Y ADP 45.1049
421 5VC5 96M 45.3287
422 6CZ3 FLJ 45.4545
423 4CSV STI 45.4545
424 2OFV 242 45.4874
425 2HK5 1BM 45.9259
426 5FBN 5WF 47.6015
427 1UNH IXM 47.9452
428 3O0G 3O0 47.9452
429 4TWP AXI 47.9705
430 4PNI KQQ 48.5981
431 4L9I 8PR 48.5981
432 4RFM 3P6 48.8722
433 3SRV S19 49.0975
434 4F4P 0SB 49.8168
435 1K3A ACP 50
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